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561 results on '"Held, L"'

4. Bevacizumab plus hypofractionated radiotherapy versus radiotherapy alone in elderly patients with glioblastoma: the randomized, open-label, phase II ARTE trial

Author

Wirsching, H.-G., Tabatabai, G., Roelcke, U., Hottinger, A.F., Jörger, F., Schmid, A., Plasswilm, L., Schrimpf, D., Mancao, C., Capper, D., Conen, K., Hundsberger, T., Caparrotti, F., von Moos, R., Riklin, C., Felsberg, J., Roth, P., Jones, D.T.W., Pfister, S., Rushing, E.J., Abrey, L., Reifenberger, G., Held, L., von Deimling, A., Ochsenbein, A., and Weller, M.

Published
2018
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7. Perspectives on scientific error

Author

van Ravenzwaaij, D., primary, Bakker, M., additional, Heesen, R., additional, Romero, F., additional, van Dongen, N., additional, Crüwell, S., additional, Field, S. M., additional, Held, L., additional, Munafò, M. R., additional, Pittelkow, M. M., additional, Tiokhin, L., additional, Traag, V. A., additional, van den Akker, O. R., additional, van ‘t Veer, A. E., additional, and Wagenmakers, E. J., additional

Published
2023
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16. Was würde der Einsatz von KI für ein Screening auf diabetische Retinopathie in der Hausarztpraxis bedeuten? Ergebnisse einer Metaanalyse

Author

Wewetzer, L, Held, L, and Steinhäuser, J

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Diabetische Retinopathie (DR) betrifft bis zu 10–24 % der Patienten mit Diabetes mellitus Typ 1 oder 2 in der Hausarztpraxis. Da Frühstadien asymptomatisch – jedoch behandelbar sind, ist eine Früherkennung entscheidend für den Erhalt des Sehens. Es gibt [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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17. The harmonic mean chi-squared test to substantiate scientific findings

Author

Held, L

Subjects
ddc: 610, type I error, combining p-values, evidence synthesis, drug regulation, 610 Medical sciences, Medicine
Abstract

Background: Statistical methodology plays a crucial role in drug regulation. Decisions by the FDA or EMA are typically made based on multiple primary studies testing the same medical product, where the two-trials rule is the standard requirement, despite a number of shortcomings. Methods: A new[for full text, please go to the a.m. URL], 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Published
2021
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18. Power Calculations for Replication Studies with an Interim Analysis

Author

Micheloud, C and Held, L

Subjects
power, sequential trial, ddc: 610, design, replication studies, 610 Medical sciences, Medicine
Abstract

As a consequence of the so-called ‘replication crisis’ [ref:1], an increasing number of replication studies have been conducted to determine the reliability of original findings. Ideally the procedures of the replication study should be as closely matched to the original study[for full text, please go to the a.m. URL], 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Published
2021
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19. The sceptical Bayes factor for the evidential assessment of replication success

Author

Pawel, S and Held, L

Subjects
ddc: 610, Bayesian hypothesis testing, reverse-Bayes analysis, 610 Medical sciences, Medicine, replication success
Abstract

The conduct of replication studies not only plays an important role in assessing the credibility of scientific discoveries, but is often a regulatory requirement in the case of clinical research. Although most researchers agree on the importance of replication studies, there is currently no agreement[for full text, please go to the a.m. URL], 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Published
2021
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20. Pan-African evolution of within- And between-country COVID-19 dynamics

Author

Ssentongo, P., Fronterre, C., Geronimo, A., Greybush, S.J., Mbabazi, P.K., Muvawala, J., Nahalamba, S.B., Omadi, P.O., Opar, B.T., Sinnar, S.A., Wang, Y., Whalen, A.J., Held, L., Jewell, C., Muwanguzi, A.J.B., Greatrex, H., Norton, M.M., Diggle, P.J., Schiff, S.J., Ssentongo, P., Fronterre, C., Geronimo, A., Greybush, S.J., Mbabazi, P.K., Muvawala, J., Nahalamba, S.B., Omadi, P.O., Opar, B.T., Sinnar, S.A., Wang, Y., Whalen, A.J., Held, L., Jewell, C., Muwanguzi, A.J.B., Greatrex, H., Norton, M.M., Diggle, P.J., and Schiff, S.J.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is heterogeneous throughout Africa and threatening millions of lives. Surveillance and short-term modeling forecasts are critical to provide timely information for decisions on control strategies. We created a strategy that helps predict the country-level case occurrences based on cases within or external to a country throughout the entire African continent, parameterized by socioeconomic and geoeconomic variations and the lagged effects of social policy and meteorological history. We observed the effect of the Human Development Index, containment policies, testing capacity, specific humidity, temperature, and landlocked status of countries on the local within-country and external between-country transmission. One-week forecasts of case numbers from the model were driven by the quality of the reported data. Seeking equitable behavioral and social interventions, balanced with coordinated country-specific strategies in infection suppression, should be a continental priority to control the COVID-19 pandemic in Africa. © 2021 National Academy of Sciences. All rights reserved.

Published
2021

25. Endemic-Epidemic Framework Used in Covid-19 Modelling

Author

Bekker-Nielsen Dunbar, M. and Held, L.

Abstract

Nunes et al. ([54]) provide an overview of mathematical models used to analyse epidemics and techniques for conducting studies to obtain parameter estimates for such models. They discuss the SEIR model which has been used in much coronavirus disease 2019 (COVID-19) analysis. Our discussion presents a modelling framework based in time series analysis developed for the analysis of infectious disease surveillance data, as well as our use of the framework in analysing COVID-19. We believe many of the purposes of modelling infectious disease outlined by Nunes et al. ([54]) as well as the benefits of mathematical modelling highlighted can also be found in the statistical modelling techniques we use in our work., REVSTAT-Statistical Journal, Vol. 18 No. 5 (2020): REVSTAT-Statistical Journal

Published
2020
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27. Forecasting based on surveillance data

Author

Held, Leonhard; https://orcid.org/0000-0002-8686-5325, Hens, Niel, O'Neill, Philip, Wallinga, Jacco, Held, L ( Leonhard ), Hens, N ( Niel ), O'Neill, P ( Philip ), Wallinga, J ( Jacco ), Meyer, Sebastian, Held, Leonhard; https://orcid.org/0000-0002-8686-5325, Hens, Niel, O'Neill, Philip, Wallinga, Jacco, Held, L ( Leonhard ), Hens, N ( Niel ), O'Neill, P ( Philip ), Wallinga, J ( Jacco ), and Meyer, Sebastian

Published
2020

38. Diagnostik und Therapie bei benignen Hodentumoren

Author

Paffenholz, P., Held, L., Pfister, D., and Heidenreich, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Kleine testikuläre Raumforderungen werden häufig als maligne Keimzelltumore missinterpretiert, sodass eine radikale inguinale Ablatio testis durchgeführt wird. Unsere Studie vergleicht die diagnostischen und therapeutischen Herangehensweisen von benignen und malignen Hodentumoren.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 63. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie

Published
2018

41. Effect of age on bone mineral density and micro architecture in the radius and tibia of horses: An Xtreme computed tomographic study

Author

Schmidlin A, Michel S, Meier D, Fürst A, Held L, and Laib A

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background The effect of age on the bone mineral density and microarchitecture of the equine radius and tibia was investigated. Fifty-six bones from 15 horses aged four to 21 years were used. There were nine geldings and six mares, and none of the horses had any disease influencing bone properties. Xtreme computed tomography was used to evaluate a 9-mm segment of the diaphysis and metaphysis of each bone. The following variables were determined: length of the bone, circumference and diameter in the frontal and sagittal planes in the middle of the bone. Diaphysis: total volume, bone volume, bone volume ratio, slice area, bone area, marrow area, cortical and marrow thickness, bone mineral density, polar moment of inertia of the cortex. Metaphysis: total area, bone area, cortical bone area, cortical thickness, bone mineral density, bone mineral density in the cortex, bone mineral density in the trabecular region, trabecular number, trabecular thickness, trabecular separation, polar moment of inertia of the metaphysis, polar moment of inertia of the cortex of the metaphysis. Results Bone density and microarchitecture were not affected by breed or gender. However, the microarchitecture varied with the age of the horse; the number of trabeculae decreased significantly and the distance between trabeculae increased significantly with increasing age. There were no significant differences between bones of the left and right limbs or between the radius and tibia. Conclusion The variables investigated did not differ between geldings and mares. However, there were age-related changes in the microstructure of the bones. Further experimental studies are necessary to determine whether these changes reduce bone strength. Age-related changes in the bones were seen and may explain the higher incidence of fractures and fissures in older horses.

Published
2008
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42. Optimizing the Design and Analysis of Clinical Trials for Antibacterials Against Multidrug-resistant Organisms: A White Paper From COMBACTE's STAT-Net

Author

Kraker, M. (Marjolein) de, Sommer, H. (Harriet), Velde, F. (Femke) de, Gravestock, I. (Isaac), Weiss, E. (Emmanuel), McAleenan, A. (Alexandra), Nikolakopoulos, S. (Stavros), Amit, O. (Ohad), Ashton, T. (Teri), Beyersmann, J. (Jan), Held, L. (Leonhard), Lovering, A.M. (Andrew M.), MacGowan, A.P. (Alasdair P.), Mouton, J.W. (Johan), Timsit, J.-F. (Jean-Francois), Wilson, D. (David), Wolkewitz, M. (Martin), Bettiol, E. (Esther), Dane, A. (Aaron), Harbarth, S. (Stephan), Kraker, M. (Marjolein) de, Sommer, H. (Harriet), Velde, F. (Femke) de, Gravestock, I. (Isaac), Weiss, E. (Emmanuel), McAleenan, A. (Alexandra), Nikolakopoulos, S. (Stavros), Amit, O. (Ohad), Ashton, T. (Teri), Beyersmann, J. (Jan), Held, L. (Leonhard), Lovering, A.M. (Andrew M.), MacGowan, A.P. (Alasdair P.), Mouton, J.W. (Johan), Timsit, J.-F. (Jean-Francois), Wilson, D. (David), Wolkewitz, M. (Martin), Bettiol, E. (Esther), Dane, A. (Aaron), and Harbarth, S. (Stephan)

Abstract

Innovations are urgently required for clinical development of antibacterials against multidrug-resistant organisms. Therefore, a European, public-private working group (STAT-Net; part of Combatting Bacterial Resistance in Europe [COMBACTE]), has reviewed and tested several innovative trials designs and analytical methods for randomized clinical trials, which has resulted in 8 recommendations. The first 3 focus on pharmacokinetic and pharmacodynamic modeling, emphasizing the pertinence of population-based pharmacokinetic models, regulatory procedures for the reassessment of old antibiotics, and rigorous quality improvement. Recommendations 4 and 5 address the need for more sensitive primary end points through the use of rank-based or time-dependent composite end points. Recommendation 6 relates to the applicability of hierarchical nested-trial designs, and the last 2 recommendations propose the incorporation of historical or concomitant trial data through Bayesian methods and/or platform trials. Although not all of these recommendations are directly applicable, they provide a solid, evidence-based approach to develop new, and established, antibacterials and address this public health challenge.

Published
2018
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43. Redefine statistical significance

Author

Benjamin, D, Berger, J, Johannesson, M, Nosek, B, Wagenmakers, E, Berk, R, Bollen, K, Brembs, B, Brown, L, Camerer, C, Cesarini, D, Chambers, C, Clyde, M, Cook, T, De Boeck, P, Dienes, Z, Dreber, A, Easwaran, K, Efferson, C, Fehr, E, Fidler, F, Field, A, Forster, M, George, E, Gonzalez, R, Goodman, S, Green, E, Green, D, Greenwald, A, Hadfield, J, Hedges, L, Held, L, Hua Ho, T, Hoijtink, H, Hruschka, D, Imai, K, Imbens, G, Ioannidis, J, Jeon, M, Jones, J, Kirchler, M, Laibson, D, List, J, Little, R, Lupia, A, Machery, E, Maxwell, S, Mccarthy, M, Moore, D, Morgan, S, Munafó, M, Nakagawa, S, Nyhan, B, Parker, T, Pericchi, L, Perugini, M, Rouder, J, Rousseau, J, Savalei, V, Schönbrodt, F, Sellke, T, Sinclair, B, Tingley, D, Van Zandt, T, Vazire, S, Watts, D, Winship, C, Wolpert, R, Xie, Y, Young, C, Zinman, J, Johnson, V, Benjamin, DJ, Berger, JO, Nosek, BA, Wagenmakers, EJ, Bollen, KA, Chambers, CD, Cook, TD, Field, AP, George, EI, Green, DP, Greenwald, AG, Hadfield, JD, Hedges, LV, Hruschka, DJ, Ioannidis, JPA, Jones, JH, Maxwell, SE, McCarthy, M, Moore, DA, Morgan, SL, Parker, TH, Schönbrodt, FD, Watts, DJ, Wolpert, RL, Johnson, VE, Benjamin, D, Berger, J, Johannesson, M, Nosek, B, Wagenmakers, E, Berk, R, Bollen, K, Brembs, B, Brown, L, Camerer, C, Cesarini, D, Chambers, C, Clyde, M, Cook, T, De Boeck, P, Dienes, Z, Dreber, A, Easwaran, K, Efferson, C, Fehr, E, Fidler, F, Field, A, Forster, M, George, E, Gonzalez, R, Goodman, S, Green, E, Green, D, Greenwald, A, Hadfield, J, Hedges, L, Held, L, Hua Ho, T, Hoijtink, H, Hruschka, D, Imai, K, Imbens, G, Ioannidis, J, Jeon, M, Jones, J, Kirchler, M, Laibson, D, List, J, Little, R, Lupia, A, Machery, E, Maxwell, S, Mccarthy, M, Moore, D, Morgan, S, Munafó, M, Nakagawa, S, Nyhan, B, Parker, T, Pericchi, L, Perugini, M, Rouder, J, Rousseau, J, Savalei, V, Schönbrodt, F, Sellke, T, Sinclair, B, Tingley, D, Van Zandt, T, Vazire, S, Watts, D, Winship, C, Wolpert, R, Xie, Y, Young, C, Zinman, J, Johnson, V, Benjamin, DJ, Berger, JO, Nosek, BA, Wagenmakers, EJ, Bollen, KA, Chambers, CD, Cook, TD, Field, AP, George, EI, Green, DP, Greenwald, AG, Hadfield, JD, Hedges, LV, Hruschka, DJ, Ioannidis, JPA, Jones, JH, Maxwell, SE, McCarthy, M, Moore, DA, Morgan, SL, Parker, TH, Schönbrodt, FD, Watts, DJ, Wolpert, RL, and Johnson, VE

Published
2018

44. Team formation processes in new ventures

Author

Held, L., Herrmann, A.M., Mossel, A. van, Held, L., Herrmann, A.M., and Mossel, A. van

Abstract

Contains fulltext : 290492.pdf (Publisher’s version ) (Open Access)

Published
2018

46. Optimizing the Design and Analysis of Clinical Trials for Antibacterials Against Multidrug-resistant Organisms: A White Paper From COMBACTE's STAT-Net

Author

Kraker, MEA, Sommer, H, de Velde, Femke, Gravestock, I, Weiss, E, McAleenan, A, Nikolakopoulos, S, Amit, O, Ashton, T, Beyersmann, J, Held, L, Lovering, AM, MacGowan, AP, Mouton, Johan, Timsit, JF, Wilson, D, Wolkewitz, M, Bettiol, E, Dane, A, Harbarth, S, Kraker, MEA, Sommer, H, de Velde, Femke, Gravestock, I, Weiss, E, McAleenan, A, Nikolakopoulos, S, Amit, O, Ashton, T, Beyersmann, J, Held, L, Lovering, AM, MacGowan, AP, Mouton, Johan, Timsit, JF, Wilson, D, Wolkewitz, M, Bettiol, E, Dane, A, and Harbarth, S

Published
2018

47. Dermoscopy of primary cutaneous intravascular large B‐cell lymphoma.

Author

Llamas‐Velasco, M., Held, L., Gold, R., and Paredes, B.

Subjects
*CUTANEOUS T-cell lymphoma, *MYCOSIS fungoides, *LYMPHOPROLIFERATIVE disorders
Abstract

We read with interest the article by Xu I et al i . on the dermoscopic patterns of early-stage mycosis fungoides (MF) in the Chinese population,[1] recently published in I Clinical and Experimental Dermatology i . IVLBCL is characterized by the proliferation of neoplastic B cells within the lumina of small- to medium-sized blood vessels, probably due to a defect in homing receptors on tumour cells. Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma. [Extracted from the article]

Published
2020
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