1,008 results on '"Heit, John A"'
Search Results
2. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
- Author
-
Abe, Namiko, Abecasis, Gonçalo, Aguet, Francois, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Ardlie, Kristin, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Ayas, Najib, Balasubramanian, Adithya, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Becker, Lewis, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Blue, Nathan, Boerwinkle, Eric, Bowden, Donald W., Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Brown, Deborah, Bunting, Karen, Burchard, Esteban, Bustamante, Carlos, Buth, Erin, Cade, Brian, Cardwell, Jonathan, Carey, Vincent, Carrier, Julie, Carson, April P., Carty, Cara, Casaburi, Richard, Casas Romero, Juan P, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Conomos, Matthew, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, de las Fuentes, Lisa, de Vries, Paul, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Dinh, Huyen, Doddapaneni, Harsha, Duan, Qing, Dugan-Perez, Shannon, Duggirala, Ravi, Durda, Jon Peter, Dutcher, Susan K., Eaton, Charles, Ekunwe, Lynette, El Boueiz, Adel, Ellinor, Patrick, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Farek, Jesse, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Geiger, Heather, Gelb, Bruce, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Gray, Kathryn J., Grine, Daniel, Gross, Colin, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Han, Yi, Hanly, Patrick, Harris, Daniel, Hawley, Nicola L., He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Hu, Jianhong, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Khan, Ziad, Kim, Wonji, Kimoff, John, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Jiwon, Lee, Sandra, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Xihong, Liu, Simin, Liu, Yongmei, Liu, Yu, Loos, Ruth J. F., Lubitz, Steven, Lunetta, Kathryn, Luo, James, Magalang, Ulysses, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manning, Alisa, Manson, JoAnn, Martin, Lisa, Marton, Melissa, Mathai, Susan, Mathias, Rasika, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, McGoldrick, Daniel, McHugh, Caitlin, McNeil, Becky, Mei, Hao, Meigs, James, Menon, Vipin, Mestroni, Luisa, Metcalf, Ginger, Meyers, Deborah A, Mignot, Emmanuel, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton D., Moll, Matt, Momin, Zeineen, Montasser, May E., Montgomery, Courtney, Muzny, Donna, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Natarajan, Pradeep, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nessner, Caitlin, Nickerson, Deborah, Nkechinyere, Osuji, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Okwuonu, Geoffrey, Pack, Allan, Paik, David T., Palmer, Nicholette, Pankow, James, Papanicolaou, George, Parker, Cora, Peloso, Gina, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S, Pleiness, Jacob, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Rajendran, Mahitha, Ramachandran, Vasan S., Rao, D. C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Reeves, Catherine, Regan, Elizabeth, Reiner, Alex, Reupena, Muagututi‘a Sefuiva, Rice, Ken, Rich, Stephen, Robillard, Rebecca, Robine, Nicolas, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Runnels, Alexi, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sabino, Ester Cerdeira, Saleheen, Danish, Salimi, Shabnam, Salvi, Sejal, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay G., Santibanez, Jireh, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sériès, Frédéric, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Skomro, Robert, Smith, Albert Vernon, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent D., Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, Van Den Berg, David, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Fei Fei, Wang, Heming, Wang, Jiongming, Watson, Karol, Watt, Jennifer, Weeks, Daniel E., Weinstock, Joshua, Weir, Bruce, Weiss, Scott T, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Winterkorn, Lara, Wong, Quenna, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yu, Ketian, Zekavat, Seyedeh Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhu, Xiaofeng, Ziv, Elad, Zody, Michael, Zoellner, Sebastian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, AlexandreTrégouët, David, Smith, Nicholas L., de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc-Quynh, Bebo, Allison, Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Lewis, Joshua P., Rodriguez, Benjamin A. T., Polasek, Ozren, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David-Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Davies, Gail, Delgado, Graciela E., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., Osburn, William O., O'Connell, Jeffrey R., Beswick, Andrew, Kolcic, Ivana, Souto, Juan Carlos, Becker, Lewis C., Hansen, Torben, Doyle, Margaret F., Harris, Sarah E., Moissl, Angela P., Rich, Stephen S., Campbell, Harry, Stott, David J., Soria, Jose Manuel, de Maat, Moniek P. M., Brody, Lawrence C., Auer, Paul L., Ben-Shlomo, Yoav, Hayward, Caroline, Mathias, Rasika A., Kilpeläinen, Tuomas O., Lange, Leslie A., Cox, Simon R., März, Winfried, Rotter, Jerome I., Mook-Kanamori, Dennis O., Wilson, James F., van der Harst, Pim, Jukema, J. Wouter, Ikram, M. Arfan, Desch, Karl C., Sabater-Lleal, Maria, Lowenstein, Charles J., and Morrison, Alanna C.
- Published
- 2024
- Full Text
- View/download PDF
3. Inherited causes of clonal haematopoiesis in 97,691 whole genomes
- Author
-
Bick, Alexander G, Weinstock, Joshua S, Nandakumar, Satish K, Fulco, Charles P, Bao, Erik L, Zekavat, Seyedeh M, Szeto, Mindy D, Liao, Xiaotian, Leventhal, Matthew J, Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J, Niroula, Abhishek, Lin, Amy E, Taub, Margaret A, Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D, Barnes, Kathleen C, Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M, Silverman, Edwin K, Weiss, Scott T, Palmer, Nicholette D, Vasan, Ramachandran S, Burchard, Esteban G, Kardia, Sharon LR, He, Jiang, Kaplan, Robert C, Smith, Nicholas L, Arnett, Donna K, Schwartz, David A, Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A, Custer, Brian, Peralta, Juan M, Gui, Hongsheng, Meyers, Deborah A, McGarvey, Stephen T, Chen, Ida Yii-Der, Shoemaker, M Benjamin, Peyser, Patricia A, Broome, Jai G, Gogarten, Stephanie M, Wang, Fei Fei, Wong, Quenna, Montasser, May E, Daya, Michelle, Kenny, Eimear E, North, Kari E, Launer, Lenore J, Cade, Brian E, Bis, Joshua C, Cho, Michael H, Lasky-Su, Jessica, Bowden, Donald W, Cupples, L Adrienne, Mak, Angel CY, Becker, Lewis C, Smith, Jennifer A, Kelly, Tanika N, Aslibekyan, Stella, Heckbert, Susan R, Tiwari, Hemant K, Yang, Ivana V, Heit, John A, Lubitz, Steven A, Johnsen, Jill M, Curran, Joanne E, Wenzel, Sally E, Weeks, Daniel E, Rao, Dabeeru C, Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P, Buth, Erin J, Rafaels, Nicholas, Loos, Ruth JF, Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I, Levy, Daniel, Bielak, Lawrence F, Hixson, James E, Floyd, James S, Whitsel, Eric A, Ellinor, Patrick T, Irvin, Marguerite R, Fingerlin, Tasha E, Raffield, Laura M, and Armasu, Sebastian M
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Biotechnology ,Regenerative Medicine ,Stem Cell Research ,Human Genome ,Underpinning research ,Aetiology ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Cardiovascular ,Generic health relevance ,Inflammatory and immune system ,Good Health and Well Being ,Adult ,Africa ,Aged ,Aged ,80 and over ,Black People ,Cell Self Renewal ,Clonal Hematopoiesis ,DNA-Binding Proteins ,Dioxygenases ,Female ,Genetic Predisposition to Disease ,Genome ,Human ,Germ-Line Mutation ,Hematopoietic Stem Cells ,Humans ,Intracellular Signaling Peptides and Proteins ,Male ,Middle Aged ,National Heart ,Lung ,and Blood Institute (U.S.) ,Phenotype ,Precision Medicine ,Proto-Oncogene Proteins ,Tripartite Motif Proteins ,United States ,Whole Genome Sequencing ,alpha Karyopherins ,NHLBI Trans-Omics for Precision Medicine Consortium ,General Science & Technology - Abstract
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer2-4 and coronary heart disease5-this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)6. Simultaneous analyses of germline and somatic whole-genome sequences provide the opportunity to identify root causes of CHIP. Here we analyse high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) programme, and identify 4,229 individuals with CHIP. We identify associations with blood cell, lipid and inflammatory traits that are specific to different CHIP driver genes. Association of a genome-wide set of germline genetic variants enabled the identification of three genetic loci associated with CHIP status, including one locus at TET2 that was specific to individuals of African ancestry. In silico-informed in vitro evaluation of the TET2 germline locus enabled the identification of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. Overall, we observe that germline genetic variation shapes haematopoietic stem cell function, leading to CHIP through mechanisms that are specific to clonal haematopoiesis as well as shared mechanisms that lead to somatic mutations across tissues.
- Published
- 2020
4. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
- Author
-
Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
- Published
- 2022
- Full Text
- View/download PDF
5. Multipoint Control for Single Axis Vibration Testing
- Author
-
Williams, Alan, Cai, Vivian, Maestas, Michael, Heit, John, Taylor, Stuart, Zimmerman, Kristin B., Series Editor, and Dervilis, Nikolaos, editor
- Published
- 2019
- Full Text
- View/download PDF
6. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis
- Author
-
Sichlau, Michael, Vlahos, Athanasios, Smith, Steven, Thalheimer, Quinn, Singh, Nisha, Harting, Rekha, Gocke, John, Guth, Scott, Shah, Neel, Brady, Paul, Schatz, Marvin, Horrow, Mindy, Markazi, Peyman, Forouzan, Leli, Matalon, Terence A.S., Hertzog, David, Goday, Swapna, Kennedy, Margaret, Kaplan, Robert, Campbell, Thomas, Hartman, Jamie, Nahum, Elmer, Venkat, Arvind, Krishnamurthy, Venkataramu, Rectenwald, John, Henke, Peter, Eliason, Jonathan, Willatt, Jonathon, Escobar, Guillermo, Samuels, Shaun, Katzen, Barry, Benenati, James, Powell, Alex, Pena, Constantino, Wallach, Howard, Gandhi, Ripal, Schneider, Joseph, Kim, Stanley, Hashemi, Farrah, Boyle, Joseph, Patel, Nilesh, Verta, Michael, Leung, Daniel, Garcia, Marc, Blatt, Phillip, Khatri, Jamil, Epstein, Dave, Ryan, Randall, Sweeny, Tom, Stillabower, Michael, Kimbiris, George, Raman, Tuhina, Sierzenski, Paul, Getto, Lelia, Dignazio, Michael, Horvath, Mark, Gornik, Heather, Bartholomew, John, Shishehbor, Mehdi, Peacock, Frank, Joseph, Douglas, Kim, Soo Hyum, Mahlay, Natalia Fendrikova, Clair, Daniel, Lyden, Sean, Kapoor, Baljendra, McLennon, Gordon, Pierce, Gregory, Newman, James, Spain, James, Gill, Amanjiit, Hamilton, Aaron, Rizzo, Anthony, Park, Woosup, Dietzek, Alan, Galin, Ira, Plummer, Dahlia, Hsu, Richard, Broderick, Patrick, Keller, Andrew, Sayeed, Sameer, Slater, Dennis, Lustberg, Herb, Akus, Jan, Sidman, Robert, Dhami, Mandeep, Kohanski, Phillip, Bulgaru, Anca, Dulala, Renuka, Burch, James, Kapur, Dinesh, Yang, Jie, Ranson, Mark, Wladis, Alan, Varnagy, David, Mekhail, Tarek, Winter, Robert, Perez-Izquierdo, Manuel, Motew, Stephen, Royd-Kranis, Robin, Workman, Raymond, Kribbs, Scott, Hogsette, Gerald, Moore, Phillip, Thomason, Bradley, Means, William, Bonsall, Richard, Stewart, John, Golwya, Daniel, Azene, Ezana, Bottner, Wayne, Bishop, William, Clayton, Dave, Gundersen, Lincoln, Riherd, Jody, Shakhnovich, Irina, Ziegelbein, Kurt, Chang, Thomas, Sharma, Karun, Allison, Sandra, Banovac, Fil, Cohen, Emil, Furlong, Brendan, Kessler, Craig, McCullough, Mike, Spies, Jim, Lin, Judith, Kaatz, Scott, Getzen, Todd, Miller, Joseph, Schwartz, Scott, Kabbani, Loay, McVinnie, David, Rundback, John, Manno, Joseph, Schwab, Richard, Cole, Randolph, Herman, Kevin, Singh, David, Barkama, Ravit, Patel, Amish, Comerota, Anthony, Pigott, John, Seiwert, Andrew, Whalen, Ralph, Russell, Todd, Assi, Zakaria, Kazanjian, Sahira, Yobbagy, Jonathan, Kaminski, Brian, Kaufman, Allan, Begeman, Garett, DiSalle, Robert, Thakur, Subash, Kim, Paul, Jacquet, Marc, Dykes, Thomas, Gerding, Joseph, Baker, Christopher, Debiasto, Mark, Mittleider, Derek, Higgins, George, III, Amberson, Steven, Pezzuti, Roger, Gallagher, Thomas, Schainfeld, Robert, Wicky, Stephan, Kalva, Sanjeeva, Walker, Gregory, Salazar, Gloria, Pomerantz, Benjamin, Patel, Virenda, Kabrhel, Christopher, Iqbal, Shams, Gangull, Suvranu, Oklu, Rahmi, Brannan, Scott, Misra, Sanjay, Bjarnason, Haraldur, Ashrani, Aneel, Caccavale, Michael, Fleming, Chad, Friese, Jeremy, Heit, John, Kalra, Manju, Macedo, Thanila, McBane, Robert, McKusick, Michael, Stockland, Andrew, Woodrum, David, Wysokinski, Waldemar, Verma, Adarsh, Davis, Andrew, Chung, Jerry, Nicker, David, Anderson, Brian, Stein, Robert, Weiss, Michael, Patel, Parag, Rilling, William, Tutton, Sean, Hieb, Robert, Hohenwalter, Eric, Colella, M. Riccardo, Gosset, James, White, Sarah, Lewis, Brian, Brown, Kellie, Rossi, Peter, Seabrook, Gary, Guimaraes, Marcelo, Selby, J. Bayne, McGary, William, Hannegan, Christopher, Robison, Jacob, Brothers, Thomas, Elliott, Bruce, Garg, Nitin, Anderson, M. Bret, Uflacker, Renan, Schonholz, Claudio, Raney, Laurence, Greenberg, Charles, Kaufman, John, Keller, Frederick, Kolbeck, Kenneth, Landry, Gregory, Mitchell, Erica, Barton, Robert, DeLoughery, Thomas, Kalbfleisch, Norman, Minjarez, Renee, Lakin, Paul, Liem, Timothy, Moneta, Gregory, Farsad, Khashayar, Fleischman, Ross, French, Loren, Marques, Vasco, Al−Hassani, Yasir, Sawar, Asad, Taylor, Frank, Patel, Rajul, Malhotra, Rahul, Hashemi, Farah, Padnick, Marvin, Gurley, Melissa, Cucher, Fred, Sterrenberg, Ronald, Deepthi, G. Reshmaal, Cumaranatunge, Gomes, Bhatla, Sumit, Jacobs, Darick, Dolen, Eric, Gamboa, Pablo, Dean, L. Mark, Davis, Thomas, Lippert, John, Khanna, Sanjeev, Schirf, Brian, Silber, Jeffrey, Wood, Donald, McGraw, J. Kevin, LaPerna, Lucy, Willette, Paul, Murphy, Timothy, Cerezo, Joselyn, Dhangana, Rajoo, Ahn, Sun Ho, Dubel, Gregory, Haas, Richard, Jay, Bryan, Prince, Ethan, Soares, Gregory, Klinger, James, Lambiase, Robert, Jay, Gregory, Tubbs, Robert, Beland, Michael, Hampson, Chris, O'Hara, Ryan, Thompson, Chad, Frodsham, Aaron, Gardiner, Fenwick, Jaffan, Abdel, Keating, Lawrence, Zafar, Abdul, Alicic, Radica, Raabe, Rodney, Brower, Jayson, McClellan, David, Pellow, Thomas, Zylak, Christopher, Davis, Joseph, Reilly, M. Kathleen, Symington, Kenneth, Seibold, Camerson, Nachreiner, Ryan, Murray, Daniel, Murray, Stephen, Saha, Sandeep, Luna, Gregory, Hodgson, Kim, McLafferty, Robert, Hood, Douglas, Moore, Colleen, Griffen, David, Hurst, Darren, Lubbers, David, Kim, Daniel, Warren, Brent, Engel, Jeremy, Suresh, D.P., VanderWoude, Eric, Razdan, Rahul, Hutchins, Mark, Rounsborg, Terry, Midathada, Madhu, Moravec, Daniel, Tilford, Joni, Beckman, Joni, Razavi, Mahmood, Openshaw, Kurt, Flanigan, D. Preston, Loh, Christopher, Dorne, Howard, Chan, Michael, Thomas, Jamie, Psaila, Justin, Ringold, Michael, Fisher, Jay, Lipcomb, Any, Oskin, Timothy, Wible, Brandt, Coleman, Brendan, Elliott, David, Gaddis, Gary, Cochran, C. Doug, Natarajan, Kannan, Bick, Stewart, Cooke, Jeffrey, Hedderman, Ann, Greist, Anne, Miller, Lorrie, Martinez, Brandon, Flanders, Vincent, Underhill, Mark, Hofmann, Lawrence, Sze, Daniel, Kuo, William, Louie, John, Hwang, Gloria, Hovsepian, David, Kothary, Nishita, Berube, Caroline, Schreiber, Donald, Jeffrey, Brooke, Schor, Jonathan, Deitch, Jonathan, Singh, Kuldeep, Hahn, Barry, Ardolic, Brahim, Gupta, Shilip, Bashir, Riyaz, Rao, Angara Koneti, Garg, Manish, Patil, Pravin, Zack, Chad, Cohen, Gary, Schmieder, Frank, Lakhter, Valdimir, Sacks, David, Guay, Robert, Scott, Mark, Cunningham, Karekin, Sigal, Adam, Cescon, Terrence, Leasure, Nick, Dhurairaj, Thiruvenkatasamy, Muck, Patrick, Knochel, Kurt, Lohr, Joann, Barreau, Jose, Recht, Matthew, Bhaskaran, Jayapandia, Brahmamdam, Ranga, Draper, David, Mehta, Apurva, Maher, James, Sharafuddin, Melhem, Lentz, Steven, Nugent, Andrew, Sharp, William, Kresowik, Timothy, Nicholson, Rachel, Sun, Shiliang, Youness, Fadi, Pascarella, Luigi, Ray, Charles, Knuttinen, Martha-Gracia, Bui, James, Gaba, Ron, Dobiesz, Valerie, Shamim, Ejaz, Nimmagadda, Sangeetha, Peace, David, Zain, Aarti, Palumto, Alison, Haskal, Ziv, Hirshon, Jon Mark, Richard, Howard, Verceles, Avelino, Wong-You-Chong, Jade, Othee, Bertrand, Patel, Rahul, Iliescu, Bogdan, Williams, David, Gemmete, Joseph, Cwikiel, Wojciech, Cho, Kyung, Schields, James, Vellody, Ranjith, Novelli, Paula, Dasika, Narasimham, Wakefield, Thomas, Desmond, Jeffrey, Froehlich, James, Khaja, Minhajuddin, Hunter, David, Golzarian, Jafar, Cressman, Erik, Dotta, Yvonne, Schmiechen, Nate, Marek, John, Garcia, David, Tawil, Isaac, Langsfeld, Mark, Moll, Stephan, Mauro, Matthew, Stavas, Joseph, Burke, Charles, Dixon, Robert, Yu, Hyeon, Keagy, Blair, Kim, Kyuny, Kasthuri, Raj, Key, Nigel, Chaer, Rabih, Makaroun, Michael, Rhee, Robert, Cho, Jae−Sung, Baril, Donald, Marone, Luke, Hseih, Margaret, Feterik, Kristian, Smith, Roy, Jeyabalan, Geetha, Rogers, Jennifer, Vinik, Russel, Kinikini, Dan, Kraiss, Larry, Mueller, Michelle, Pendleton, Robert, Rondina, Matthew, Sarfati, Mark, Wanner, Nathan, Johnson, Stacy, Hopkins, Christy, Ihnat, Daniel, Angle, John, Matsumoto, Alan, Harthun, Nancy, Turba, Ulku, Saad, Wael, Uthlaut, Brian, Nannapaneni, Srikant, Ling, David, Sabri, Saher, Kern, John, Macik, B. Gail, Hoke, George, Park, Auh Wahn, Stone, James, Sneed, Benjamin, Syverud, Scott, Davidson, Kelly, Sharma, Aditya, Wilkins, Luke, Black, Carl, Asay, Mark, Hatch, Daniel, Smilanich, Robert, Patten, Craig, Brown, S. Douglas, Nielsen, Ryan, Alward, William, Collins, John, Nokes, Matthew, Geary, Randolph, Edwards, Matthew, Godshall, Christopher, Levy, Pavel, Winokur, Ronald, Sista, Akhilesh, Madoff, David, Lee, Kyungmouk, Pua, Bradley, DeSancho, Maria, Milizia, Raffaele, Gao, Jing, McLean, Gordon, Khalid, Sanualah, Vedantham, Suresh, Lewis, Larry, Saad, Nael, Thoelke, Mark, Pallow, Robert, Klein, Seth, Sicard, Gregorio, Cohen, David J., Comerota, Anthony J., Gornik, Heather L., Jaff, Michael R., Julian, Jim, Kahn, Susan R., Kearon, Clive, Kee, Stephen, Kindzelski, Andrei L., Lewis, Lawrence, Magnuson, Elizabeth, Razavi, Mahmood K., Murphy, Timothy P., Julian, Jim A., Gu, Chu-Shu, Magnuson, Elizabeth A., Goldhaber, Samuel Z., Schneider, Joseph R., Sista, Akhilesh K., McLafferty, Robert B., Kaufman, John A., Wible, Brandt C., and Blinder, Morey
- Published
- 2020
- Full Text
- View/download PDF
7. Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study.
- Author
-
Miller, Virginia M, Jenkins, Gregory D, Biernacka, Joanna M, Heit, John A, Huggins, Gordon S, Hodis, Howard N, Budoff, Matthew J, Lobo, Rogerio A, Taylor, Hugh S, Manson, JoAnn E, Black, Dennis M, Naftolin, Frederick, Harman, S Mitchell, and de Andrade, Mariza
- Subjects
Carotid Arteries ,Coronary Vessels ,Animals ,Horses ,Humans ,Calcinosis ,Estrogens ,Confidence Intervals ,Pharmacogenetics ,Phenotype ,Polymorphism ,Single Nucleotide ,Time Factors ,Female ,Immunity ,Innate ,Genetic Association Studies ,Carotid Intima-Media Thickness ,atherosclerosis ,candidate genes ,estrogen ,innate immunity ,thrombosis ,Polymorphism ,Single Nucleotide ,Immunity ,Innate ,Biochemistry & Molecular Biology ,Medical Physiology - Abstract
Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid artery intima-medial thickness (CIMT) and coronary arterial calcification (CAC) in women (n = 606) enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Whether MHT might affect these associations is unknown. The association of treatment outcomes with variation in the same 764 candidate genes was evaluated in the same KEEPS participants 4 yr after randomization to either oral conjugated equine estrogens (0.45 mg/day), transdermal 17β-estradiol (50 μg/day), each with progesterone (200 mg/day) for 12 days each month, or placebo pills and patch. Twenty SNPs within the innate immunity pathway most related with CIMT after 4 yr were not among those associated with CIMT prior to MHT. In 403 women who completed the study in their assigned treatment group, single nucleotide polymorphisms (SNPs) within the innate immunity pathway were found to alter the treatment effect on 4 yr change in CIMT (i.e., significant interaction between treatment and genetic variation in the innate immunity pathway; P < 0.001). No SNPs by treatment effects were observed with changes of CAC >5 Agatston units after 4 yr. Results of this study suggest that hormonal status may interact with genetic variants to influence cardiovascular phenotypes, specifically, the pharmacogenomic effects within the innate immunity pathway for CIMT.
- Published
- 2016
8. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
- Author
-
Lindström, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Damrauer, Scott M., Natarajan, Pradeep, Klarin, Derek, de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, Trégouët, David-Alexandre, and Smith, Nicholas L.
- Published
- 2019
- Full Text
- View/download PDF
9. Heart Disease and Stroke Statistics—2014 Update
- Author
-
Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Blaha, Michael J, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Judd, Suzanne E, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Mackey, Rachel H, Magid, David J, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Neumar, Robert W, Nichol, Graham, Pandey, Dilip K, Paynter, Nina P, Reeves, Matthew J, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, and Turner, Melanie B
- Subjects
American Heart Association ,Cardiology ,Heart Diseases ,Humans ,Stroke ,United States ,AHA Scientific Statements ,cardiovascular diseases ,epidemiology ,risk factors ,statistics ,stroke ,American Heart Association Statistics Committee and Stroke Statistics Subcommittee ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a critical resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best available national data on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, use of medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions. In 2012 alone, the various Statistical Updates were cited ≈3500 times (data from Google Scholar). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled. For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year. This year's edition includes a new chapter on peripheral artery disease, as well as new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals. Below are a few highlights from this year's Update. © 2013 American Heart Association, Inc.
- Published
- 2014
10. Executive Summary
- Author
-
Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Blaha, Michael J, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Judd, Suzanne E, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Mackey, Rachel H, Magid, David J, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Neumar, Robert W, Nichol, Graham, Pandey, Dilip K, Paynter, Nina P, Reeves, Matthew J, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, and Turner, Melanie B
- Subjects
American Heart Association ,Cardiology ,Heart Diseases ,Humans ,Prevalence ,Research Report ,Risk Factors ,Stroke ,United States ,AHA Scientific Statements ,cardiovascular diseases ,epidemiology ,risk factors ,statistics ,stroke ,American Heart Association Statistics Committee and Stroke Statistics Subcommittee ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a critical resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best available national data on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, use of medical procedures and operations, and costs associated with the management of these diseases in a single document. Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions. In 2012 alone, the various Statistical Updates were cited ≈3500 times (data from Google Scholar). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled. For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year. This year's edition includes a new chapter on peripheral artery disease, as well as new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals. Below are a few highlights from this year's Update. © 2013 American Heart Association, Inc.
- Published
- 2014
11. Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association.
- Author
-
Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Blaha, Michael J, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Judd, Suzanne E, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Mackey, Rachel H, Magid, David J, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Neumar, Robert W, Nichol, Graham, Pandey, Dilip K, Paynter, Nina P, Reeves, Matthew J, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, Turner, Melanie B, and American Heart Association Statistics Committee and Stroke Statistics Subcommittee
- Subjects
American Heart Association Statistics Committee and Stroke Statistics Subcommittee ,Humans ,Heart Diseases ,Prevalence ,Risk Factors ,Cardiology ,American Heart Association ,United States ,Stroke ,Research Report ,AHA Scientific Statements ,cardiovascular diseases ,epidemiology ,risk factors ,statistics ,stroke ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services - Published
- 2014
12. Vibro-Acoustic Modulation of a Spinning Apparatus for Nondestructive Evaluation
- Author
-
Ward, Martin J., Scott, Wesley E., Diskerud, Nicholas M., Cattaneo, Alessandro, Heit, John D., Bernardin, John D., Zimmerman, Kristin B., Series editor, Di Maio, Dario, editor, and Castellini, Paolo, editor
- Published
- 2017
- Full Text
- View/download PDF
13. Is Infection an Independent Risk Factor for Venous Thromboembolism? A Population-Based, Case-Control Study
- Author
-
Cohoon, Kevin P., Ashrani, Aneel A., Crusan, Daniel J., Petterson, Tanya M., Bailey, Kent R., and Heit, John A.
- Published
- 2018
- Full Text
- View/download PDF
14. Coronary Embolus: An Underappreciated Cause of Acute Coronary Syndromes
- Author
-
Raphael, Claire E., Heit, John A., Reeder, Guy S., Bois, Melanie C., Maleszewski, Joseph J., Tilbury, R. Thomas, and Holmes, David R., Jr.
- Published
- 2018
- Full Text
- View/download PDF
15. Heart disease and stroke statistics--2013 update: a report from the American Heart Association.
- Author
-
Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Borden, William B, Bravata, Dawn M, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Magid, David, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Nichol, Graham, Paynter, Nina P, Schreiner, Pamela J, Sorlie, Paul D, Stein, Joel, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, Turner, Melanie B, and American Heart Association Statistics Committee and Stroke Statistics Subcommittee
- Subjects
American Heart Association Statistics Committee and Stroke Statistics Subcommittee ,Humans ,Heart Diseases ,Prevalence ,Risk Factors ,American Heart Association ,United States ,Stroke ,AHA Scientific Statements ,cardiovascular diseases ,epidemiology ,risk factors ,statistics ,stroke ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update*The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best national data available on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, medical procedures and operations, and costs associated with the management of these diseases in a single document*Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions*In 2011 alone, the various Statistical Updates were cited ≈1500 times (data from ISI Web of Science)*In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled*For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year*This year's edition also implements a new chapter organization to reflect the spectrum of cardiovascular health behaviors and health factors and risks, as well as subsequent complicating conditions, disease states, and outcomes*Also, the 2013 Statistical Update contains new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals*Below are a few highlights from this year's Update . © 2013 American Heart Association, Inc.
- Published
- 2013
16. Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.
- Author
-
Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Borden, William B, Bravata, Dawn M, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Magid, David, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Nichol, Graham, Paynter, Nina P, Schreiner, Pamela J, Sorlie, Paul D, Stein, Joel, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, Turner, Melanie B, and American Heart Association Statistics Committee and Stroke Statistics Subcommittee
- Subjects
American Heart Association Statistics Committee and Stroke Statistics Subcommittee ,Humans ,Heart Diseases ,Obesity ,Prevalence ,Age Distribution ,American Heart Association ,United States ,Stroke ,AHA Scientific Statements ,cardiovascular diseases ,epidemiology ,risk factors ,statistics ,stroke ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update.*The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media professionals, the lay public, and many others who seek the best national data available on heart disease, stroke, and other cardiovascular disease-related morbidity and mortality and the risks, quality of care, medical procedures and operations, and costs associated with the management of these diseases in a single document Indeed, since 1999, the Statistical Update has been cited >10 500 times in the literature, based on citations of all annual versions. In 2011 alone, the various Statistical Updates were cited ∼1500 times (data from ISI Web of Science). In recent years, the Statistical Update has undergone some major changes with the addition of new chapters and major updates across multiple areas, as well as increasing the number of ways to access and use the information assembled. For this year's edition, the Statistics Committee, which produces the document for the AHA, updated all of the current chapters with the most recent nationally representative data and inclusion of relevant articles from the literature over the past year. This year's edition also implements a new chapter organization to reflect the spectrum of cardiovascular health behaviors and health factors and risks, as well as subsequent complicating conditions, disease states, and outcomes. Also, the 2013 Statistical Update contains new data on the monitoring and benefits of cardiovascular health in the population, with additional new focus on evidence-based approaches to changing behaviors, implementation strategies, and implications of the AHA's 2020 Impact Goals. Below are a few highlights from this year's Update. © 2013 American Heart Association, Inc.
- Published
- 2013
17. Enhanced Spin-Down Diagnostics for Nondestructive Evaluation of High-Value Systems
- Author
-
Sehloff, David, Shurtleff, Clark, Pribe, Josh, Haynes, Colin, Heit, John, Zimmerman, Kristin B., Series editor, De Clerck, James, editor, and Epp, David S., editor
- Published
- 2016
- Full Text
- View/download PDF
18. Effect of a near-universal hospitalization-based prophylaxis regimen on annual number of venous thromboembolism events in the US
- Author
-
Heit, John A., Crusan, Daniel J., Ashrani, Aneel A., Petterson, Tanya M., and Bailey, Kent R.
- Published
- 2017
- Full Text
- View/download PDF
19. Periprocedural Anticoagulation Management of Patients with Thrombophilia
- Author
-
Wysokinska, Ewa M., Wysokinski, Waldemar E., Ketha, Siva, Litin, Scott, Daniels, Paul, Slusser, Joshua, Hodge, David O., Heit, John A., and McBane, Robert D., II
- Published
- 2016
- Full Text
- View/download PDF
20. Remote Placement of Magnetically Coupled Ultrasonic Sensors for Structural Health Monitoring
- Author
-
Gunawardena, Nipun, Heit, John, Lederman, George, Galbraith, Amy, Mascareñas, David, Foss, Gary, editor, and Niezrecki, Christopher, editor
- Published
- 2014
- Full Text
- View/download PDF
21. Multipoint Control for Single Axis Vibration Testing
- Author
-
Williams, Alan, primary, Cai, Vivian, additional, Maestas, Michael, additional, Heit, John, additional, and Taylor, Stuart, additional
- Published
- 2018
- Full Text
- View/download PDF
22. Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: A cohort study
- Author
-
Kumar, Riten, Rodriguez, Vilmarie, Matsumoto, Jane M.S., Khan, Shakila P., Weaver, Amy L., McBane, Robert D., Beebe, Timothy J., and Heit, John A.
- Published
- 2015
- Full Text
- View/download PDF
23. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study
- Author
-
Lindström, Sara, Germain, Marine, Crous-Bou, Marta, Smith, Erin N., Morange, Pierre-Emmanuel, van Hylckama Vlieg, Astrid, de Haan, Hugoline G., Chasman, Daniel, Ridker, Paul, Brody, Jennifer, de Andrade, Mariza, Heit, John A., Tang, Weihong, DeVivo, Immaculata, Grodstein, Francine, Smith, Nicholas L., Tregouet, David, Kabrhel, Christopher, and for the INVENT Consortium
- Published
- 2017
- Full Text
- View/download PDF
24. Validity of International Classification of Diseases, Ninth Revision, Clinical Modification codes for estimating the prevalence of venous ulcer
- Author
-
Gloviczki, Monika L., Kalsi, Henna, Gloviczki, Peter, Gibson, Matthew, Cha, Stephen, and Heit, John A.
- Published
- 2014
- Full Text
- View/download PDF
25. Genetically predicted cortisol levels and risk of venous thromboembolism
- Author
-
Allarai, Elias, Lee, Wei-Hsuan, Burgess, Stephen, Larsson, Susanna C., Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, Van Hylckama Vlieg, Astrid, De Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben Michael, Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., Macdonald, James, Brækkan, Sigrid Kufaas, Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., Mccauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken Elvestad, Deleuze, Jean-Francois, O'Donnell, Chris J., Kim, Jihye, Mcknight, Barbara, Kraft, Peter, Hansen, John Bjarne, Rosendaal, Frits Richard, Heit, John A., Psaty, Bruce M., Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, Alexandretrégouët, David, Smith, Nicholas L., Allara, Elias [0000-0002-1634-8330], Burgess, Stephen [0000-0001-5365-8760], and Apollo - University of Cambridge Repository
- Subjects
Medicine and health sciences ,Multidisciplinary ,Kardiologi ,Hydrocortisone ,Biology and life sciences ,FOS: Social sciences ,Venous Thromboembolism ,Mendelian Randomization Analysis ,Endocrinology and Diabetes ,Social sciences ,Risk Factors ,Endokrinologi och diabetes ,Humans ,Cardiac and Cardiovascular Systems ,Pulmonary Embolism ,Medical Genetics ,Medicinsk genetik ,Research Article - Abstract
Introduction In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk using Mendelian randomization. Methods Three genetic variants in the SERPINA1/SERPINA6 locus (rs12589136, rs11621961 and rs2749527) were used to proxy plasma cortisol. The associations of the cortisol-associated genetic variants with VTE were acquired from the INVENT (28 907 cases and 157 243 non-cases) and FinnGen (6913 cases and 169 986 non-cases) consortia. Corresponding data for VTE subtypes were available from the FinnGen consortium and UK Biobank. Two-sample Mendelian randomization analyses (inverse-variance weighted method) were performed. Results Genetic predisposition to higher plasma cortisol levels was associated with a reduced risk of VTE (odds ratio [OR] per one standard deviation increment 0.73, 95% confidence interval [CI] 0.62–0.87, p Conclusions This study provides evidence that genetically predicted plasma cortisol levels in the high end of the normal range are associated with a decreased risk of VTE and that this association may be mediated by blood pressure. This study has implications for the planning of observational studies of cortisol and VTE, suggesting that blood pressure traits should be measured and accounted for.
- Published
- 2022
26. Are myocardial infarction and venous thromboembolism associated? Population-based case–control and cohort studies
- Author
-
Barsoum, Michel K., Cohoon, Kevin P., Roger, Véronique L., Mehta, Ramila A., Hodge, David O., Bailey, Kent R., and Heit, John A.
- Published
- 2014
- Full Text
- View/download PDF
27. Differences in Thrombotic Risk Factors in Black and White Women with Adverse Pregnancy Outcome
- Author
-
Philipp, Claire S., Faiz, Ambarina S., Beckman, Michele G., Grant, Althea, Bockenstedt, Paula L., Heit, John A., James, Andra H., Kulkarni, Roshni, Manco-Johnson, Marilyn J., Moll, Stephan, and Ortel, Thomas L.
- Published
- 2014
- Full Text
- View/download PDF
28. Risk Factors for Thrombosis in Cancer Patients
- Author
-
Ashrani, Aneel A., Heit, John A., Kwaan, Hau C., editor, and Green, David, editor
- Published
- 2009
- Full Text
- View/download PDF
29. Coagulation Disorders
- Author
-
Pruthi, Rajiv K., Heit, John A., Leonard, Debra G. B., editor, Bagg, Adam, editor, Caliendo, Angela M., editor, Kaul, Karen L., editor, and Van Deerlin, Vivianna M., editor
- Published
- 2007
- Full Text
- View/download PDF
30. Outcomes and total costs of outpatient vs. inpatient peri-procedural anticoagulation management of mechanical prosthetic heart valve patients
- Author
-
Attaya, Hosam, Shah, Nilay D., Wysokinski, Waldemar E., Van Houten, Holly K., Heit, John A., and McBane, Robert D., II
- Published
- 2013
- Full Text
- View/download PDF
31. The epidemiology of venous thromboembolism
- Author
-
Heit, John A., Spencer, Frederick A., and White, Richard H.
- Published
- 2016
- Full Text
- View/download PDF
32. Thrombin generation profiles as predictors of symptomatic venous thromboembolism after trauma: A prospective cohort study
- Author
-
Park, Myung S., Spears, Grant M., Bailey, Kent R., Xue, Ailing, Ferrara, Michael J., Headlee, Amy, Dhillon, Sabtir K., Jenkins, Donald H., Zietlow, Scott P., Harmsen, William S., Ashrani, Aneel A., and Heit, John A.
- Published
- 2017
- Full Text
- View/download PDF
33. The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies
- Author
-
Dennis, Jessica, Johnson, Candice Y., Adediran, Adeniyi Samuel, de Andrade, Mariza, Heit, John A., Morange, Pierre-Emmanuel, Trégouët, David-Alexandre, and Gagnon, France
- Published
- 2012
- Full Text
- View/download PDF
34. Age- and Sex-Specific Incidence of Cerebral Venous Sinus Thrombosis Associated With Ad26.COV2.S COVID-19 Vaccination
- Author
-
Ashrani, Aneel A., primary, Crusan, Daniel J., additional, Petterson, Tanya, additional, Bailey, Kent, additional, and Heit, John A., additional
- Published
- 2022
- Full Text
- View/download PDF
35. Enhanced Spin-Down Diagnostics for Nondestructive Evaluation of High-Value Systems
- Author
-
Sehloff, David, primary, Shurtleff, Clark, additional, Pribe, Josh, additional, Haynes, Colin, additional, and Heit, John, additional
- Published
- 2016
- Full Text
- View/download PDF
36. Identifying In-Hospital Venous Thromboembolism (VTE): A Comparison of Claims-Based Approaches with the Rochester Epidemiology Project VTE Cohort
- Author
-
Leibson, Cynthia L., Needleman, Jack, Buerhaus, Peter, Heit, John A., Melton, L. Joseph, Naessens, James M., Bailey, Kent R., Petterson, Tanya M., Ransom, Jeanine E., and Harris, Marcelline R.
- Published
- 2008
37. Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study
- Author
-
Heit, John A., Lahr, Brian D., Petterson, Tanya M., Bailey, Kent R., Ashrani, Aneel A., and Melton, L. Joseph, III
- Published
- 2011
- Full Text
- View/download PDF
38. Incidence of Venous Thromboembolism After Bariatric Surgery: A Population-Based Cohort Study
- Author
-
Froehling, David A., Daniels, Paul R., Mauck, Karen F., Collazo-Clavell, Maria L., Ashrani, Aneel A., Sarr, Michael G., Petterson, Tanya M., Bailey, Kent R., and Heit, John A.
- Published
- 2013
- Full Text
- View/download PDF
39. Plasma von Willebrand factor multimer quantitative analysis by in-gel immunostaining and infrared fluorescent imaging
- Author
-
Pruthi, Rajiv K., Daniels, Todd M., Heit, John A., Chen, Dong, Owen, Whyte G., and Nichols, William L.
- Published
- 2010
- Full Text
- View/download PDF
40. Correction to: Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study
- Author
-
Lindström, Sara, Germain, Marine, Crous-Bou, Marta, Smith, Erin N., Morange, Pierre-Emmanuel, van Hylckama Vlieg, Astrid, de Haan, Hugoline G., Chasman, Daniel, Ridker, Paul, Brody, Jennifer, de Andrade, Mariza, Heit, John A., Tang, Weihong, De Vivo, Immaculata, Grodstein, Francine, Smith, Nicholas L., Tregouet, David, Kabrhel, Christopher, and for the INVENT Consortium
- Published
- 2018
- Full Text
- View/download PDF
41. Epidemiology of venous thromboembolism
- Author
-
Heit, John A.
- Published
- 2015
- Full Text
- View/download PDF
42. Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: A population-based longitudinal study
- Author
-
Cohoon, Kevin P., Leibson, Cynthia L., Ransom, Jeanine E., Ashrani, Aneel A., Park, Myung S., Petterson, Tanya M., Long, Kirsten Hall, Bailey, Kent R., and Heit, John A.
- Published
- 2015
- Full Text
- View/download PDF
43. Peri-procedural anticoagulation management of mechanical prosthetic heart valve patients
- Author
-
Daniels, Paul R., McBane, Robert D., Litin, Scott C., Ward, Sue A., Hodge, David O., Dowling, Nicole F., and Heit, John A.
- Published
- 2009
- Full Text
- View/download PDF
44. Direct Medical Costs Attributable to Cancer-Associated Venous Thromboembolism: A Population-Based Longitudinal Study
- Author
-
Cohoon, Kevin P., Ransom, Jeanine E., Leibson, Cynthia L., Ashrani, Aneel A., Petterson, Tanya M., Long, Kirsten Hall, Bailey, Kent R., and Heit, John A.
- Published
- 2016
- Full Text
- View/download PDF
45. Three-month cumulative incidence of thromboembolism and bleeding after periprocedural anticoagulation management of arterial vascular bypass patients
- Author
-
Attaya, Hosam, Wysokinski, Waldemar E., Bower, Thomas, Litin, Scott, Daniels, Paul R., Slusser, Joshua, Heit, John A., and McBane, II, Robert D.
- Published
- 2013
- Full Text
- View/download PDF
46. Echo: Data and Analysis Management
- Author
-
Harvey, Dustin Yewell, primary, Taylor, Stuart Glynn, additional, Haynes, Colin Michael, additional, Heit, John Dale, additional, Ouellette, Scott Anthony, additional, and Flynn, Eric Brian, additional
- Published
- 2017
- Full Text
- View/download PDF
47. Remote Placement of Magnetically Coupled Ultrasonic Sensors for Structural Health Monitoring
- Author
-
Gunawardena, Nipun, primary, Heit, John, additional, Lederman, George, additional, Galbraith, Amy, additional, and Mascareñas, David, additional
- Published
- 2014
- Full Text
- View/download PDF
48. Cerebral small vessel disease genomics and its implications across the lifespan
- Author
-
Sargurupremraj, Muralidharan, Suzuki, Hideaki, Zhao, Wei, Okada, Yukinori, Mazoyer, Bernard, Wardlaw, Joanna M, Nyquist, Paul A, Mather, Karen A, Grabe, Hans, Schmidt, Helena, Van Duijn, Cornelia M, Gudnason, Vilmundur, Longstreth, William T, Armstrong, Nicola J, Launer, Lenore J, Lathrop, Mark, Seshadri, Sudha, Tzourio, Christophe, Adams, Hieab H, Matthews, Paul M, Fornage, Myriam, Debette, Stéphanie, Amouyel, Philippe, de Andrade, Mariza, Hofer, Edith, Basu, Saonli, Berr, Claudine, Brody, Jennifer A, Chasman, Daniel I, Dartigues, Jean-Francois, Folsom, Aaron R, Germain, Marine, de Haan, Hugoline, Heit, John, Houwing-Duitermaat, Jeanine, Yanek, Lisa R, Kabrhel, Christopher, Kraft, Peter, Legal, Grégoire, Lindström, Sara, Monajemi, Ramin, Morange, Pierre-Emmanuel, Psaty, Bruce M, Reitsma, Pieter H, Ridker, Paul M, Rose, Lynda M, Hagenaars, Saskia P, Rosendaal, Frits R, Saut, Noémie, Slagboom, Eline, Smadja, David, Smith, Nicholas L, Suchon, Pierre, Tang, Weihong, Taylor, Kent D, Trégouët, David-Alexandre, Kumar, Rajan B, de Visser, Marieke C H, van Hylckama Vlieg, Astrid, Weng, Lu-Chen, Wiggins, Kerri L, Gormley, Padhraig, Anttila, Verneri, Winsvold, Bendik S, Palta, Priit, Esko, Tonu, Pers, Tune H, van den Akker, Erik B, Farh, Kai-How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A, Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M, Kallela, Mikko, McWhirter, Rebekah E, Freilinger, Tobias M, Ran, Caroline, Gordon, Scott G, Stam, Anine H, Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H H, Lehtimäki, Terho, Trompet, Stella, Sarin, Antti-Pekka, Wedenoja, Juho, Hinds, David A, Buring, Julie E, Schürks, Markus, Gudlaug Hrafnsdottir, Maria, Stefansson, Hreinn, Ring, Susan M, Hottenga, Jouke-Jan, Mishra, Aniket, Penninx, Brenda W J H, Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Jian, Xueqiu, Saba, Yasaman, Kurki, Mitja, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E, Franke, Lude, Huang, Jie, Stergiakouli, Evie, Satizabal, Claudia L, Lee, Phil H, Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefanie, Meitinger, Thomas, Eriksson, Johan G, Salomaa, Veikko, Heikkilä, Kauko, Beaudet, Gregory, Loehrer, Elizabeth, Uitterlinden, Andre G, Hofman, Albert, van Duijn, Cornelia M, Cherkas, Lynn, Pedersen, Linda M, Stubhaug, Audun, Nielsen, Christopher S, Männikkö, Minna, Mihailov, Evelin, Petit, Laurent, Milani, Lili, Göbel, Hartmut, Esserlind, Ann-Louise, Francke Christensen, Anne, Folkmann Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J, Raitakari, Olli, Ikram, M Arfan, Tsuchida, Ami, Spector, Tim, Järvelin, Marjo-Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P, Ferrari, Michel D, Belin, Andrea C, Dichgans, Martin, Wessman, Maija, van den Maagdenberg, Arn M J M, Zago, Laure, Zwart, John-Anker, Boomsma, Dorret I, Davey Smith, George, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J, Neale, Benjamin M, Olesen, Jes, Nyholt, Dale R, Schilling, Sabrina, Palotie, Aarno, Sigurdsson, Sigurdur, Gottesman, Rebecca F, Lewis, Cora E, Sarnowski, Chloé, Aggarwal, Neelum T, Lopez, Oscar L, Smith, Jennifer A, Valdés Hernández, Maria C, van der Grond, Jeroen, Wright, Margaret J, Knol, Maria J, Dörr, Marcus, Thomson, Russell J, Bordes, Constance, Evans, Tavia E, Le Grand, Quentin, Duperron, Marie-Gabrielle, Smith, Albert V, Knopman, David S, Schreiner, Pamela J, Evans, Denis A, Rotter, Jerome I, Beiser, Alexa S, Maniega, Susana Muñoz, Beekman, Marian, Bis, Joshua C, Trollor, Julian, Stott, David J, Vernooij, Meike W, Wittfeld, Katharina, Niessen, Wiro J, Soumaré, Aicha, Boerwinkle, Eric, Sidney, Stephen, Turner, Stephen T, Davies, Gail, Eiriksdottir, Gudny, Thalamuthu, Anbupalam, Völker, Uwe, van Buchem, Mark A, Bryan, R Nick, Dupuis, Josée, Bastin, Mark E, Ames, David, Teumer, Alexander, Kwok, John B, Sakaue, Saori, Bülow, Robin, Deary, Ian J, Schofield, Peter R, Brodaty, Henry, Jiang, Jiyang, Tabara, Yasuharu, Setoh, Kazuya, Miyamoto, Susumu, Yoshida, Kazumichi, Nagata, Manabu, Terzikhan, Natalie, Kamatani, Yoichiro, Matsuda, Fumihiko, Bennett, David A, De Jager, Philip L, Mosley, Thomas H, Sachdev, Perminder S, Schmidt, Reinhold, Warren, Helen R, Evangelou, Evangelos, Habes, Mohamad, Thrombosis, International Network against, Consortium, International Headache Genomics, Ikram, Mohammad A, Wen, Wei, DeCarli, Charles, Srikanth, Velandai K, Jukema, J Wouter, Slagboom, Eline P, Kardia, Sharon L R, Equipe VINTAGE - Inserm U1219 [Bordeaux], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe d'imagerie neurofonctionnelle (GIN), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), and Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
- Subjects
Adult ,Male ,epidemiology [Alzheimer Disease] ,genetics [Alzheimer Disease] ,diagnosis [Cerebral Small Vessel Diseases] ,epidemiology [Hypertension] ,Genome-wide association studies ,behavioral disciplines and activities ,Risk Assessment ,Article ,diagnostic imaging [White Matter] ,Young Adult ,Alzheimer Disease ,Risk Factors ,White matter disease ,mental disorders ,Humans ,Medical History Taking ,Aged ,Aged, 80 and over ,[SCCO.NEUR]Cognitive science/Neuroscience ,Mendelian Randomization Analysis ,Middle Aged ,White Matter ,Stroke ,Diffusion Tensor Imaging ,Genetic Loci ,Cerebral Small Vessel Diseases ,complications [Cerebral Small Vessel Diseases] ,Hypertension ,genetics [Stroke] ,genetics [Cerebral Small Vessel Diseases] ,Female ,genetics [Hypertension] ,ddc:500 ,epidemiology [Stroke] ,Genome-Wide Association Study - Abstract
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials., White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.
- Published
- 2020
49. Alterations in Platelet Function and Cell-Derived Microvesicles in Recently Menopausal Women: Relationship to Metabolic Syndrome and Atherogenic Risk
- Author
-
Jayachandran, Muthuvel, Litwiller, Robert D., Lahr, Brian D., Bailey, Kent R., Owen, Whyte G., Mulvagh, Sharon L., Heit, John A., Hodis, Howard N., Harman, S. Mitchell, and Miller, Virginia M.
- Published
- 2011
- Full Text
- View/download PDF
50. Prevention of Venous Thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
- Author
-
Geerts, William H., Bergqvist, David, Pineo, Graham F., Heit, John A., Samama, Charles M., Lassen, Michael R., and Colwell, Clifford W.
- Published
- 2008
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.