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20 results on '"Heinzinger, Catherine"'

7. Sleep‐Disordered Breathing, Hypoxia, and Pulmonary Physiologic Influences in Atrial Fibrillation

Author

Heinzinger, Catherine M., primary, Thompson, Nicolas R., additional, Milinovich, Alex, additional, Diniz Araujo, Matheus Lima, additional, Orbea, Cinthya Pena, additional, Foldvary‐Schaefer, Nancy, additional, Haouzi, Philippe, additional, Faulx, Michael, additional, Van Wagoner, David R., additional, Chung, Mina K., additional, and Mehra, Reena, additional

Published
2023
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15. 465 Evaluating the Impact of Sleep Disordered Breathing on Adverse Cardiovascular Outcomes After Bariatric Surgery

Author

Heinzinger, Catherine, primary, Chindamporn, Pornprapa, additional, Bena, James, additional, Wang, Lu, additional, Milinovich, Alex, additional, Kaw, Roop, additional, Kashyap, Sangeeta, additional, Cetin, Derrick, additional, Aminian, Ali, additional, Kempke, Nancy, additional, Foldvary-Schaefer, Nancy, additional, Aboussouan, Loutfi, additional, and Mehra, Reena, additional

Published
2021
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19. Identifying and Cardiac Risk-Stratifying Obstructive Sleep Apnea Phenotypic Clusters in a Large Clinical Cohort

Author

Heinzinger, Catherine M.

Subjects
Anatomy and Physiology, Biology, Biomedical Research, Biostatistics, Health, Health Care, Health Sciences, Medicine, Neurology, Neurosciences, Neurobiology, Statistics, sleep, atrial fibrillation, sleep apnea, obstructive sleep apnea, hypoxia, sleep-related hypoxia, phenotypes, subtypes, clusters, sleep symptoms, sleep study data, latent class analysis, time-to-event analysis
Abstract

While sleep disorders are implicated in atrial fibrillation (AF), interplay of physiologic alterations and symptoms remains unclear. Sleep-based subtypes can account for this complexity. We hypothesized discrete phenotypes of symptoms and polysomnography-based data on adult patients in the STARLIT Registry (n=43,433) differ in relation to incident AF (8.9%, n=3,596). Clusters, identified using latent class analysis, were used as predictors in multivariable-adjusted Cox proportional hazards models. Five clusters were identified: ‘Hypoxic + Sleepy’ had 48% increased risk, ‘Apneas + Arousals’ 22% increased risk, and ‘Short Sleep + Low %REM’ 11% increased risk of incident AF compared to ‘Long Sleep + High %REM’, and ‘Hypopneas’ did not differ over a 7.6±3.4 year follow-up period. Consistent with prior evidence of hypoxia as an AF driver and cardiac risk of the sleepy phenotype, this constellation of symptoms and physiologic alterations illustrates risk in the clinical setting, providing potential value as a risk prediction tool.

Published
2023

20. Adverse Cardiovascular Outcomes in Patients With Obstructive Sleep Apnea and Obesity: Metabolic Surgery vs Usual Care.

Author

Aminian, Ali, Wang, Lu, Al Jabri, Abdullah, Wilson, Rickesha, Bena, James, Milinovich, Alex, Jin, Jian, Heinzinger, Catherine, Pena-Orbea, Cinthya, Foldvary-Schaefer, Nancy, Nissen, Steven E., and Mehra, Reena

Subjects
*MAJOR adverse cardiovascular events, *SLEEP apnea syndromes, *BODY mass index, *BARIATRIC surgery, *WEIGHT loss
Abstract

No therapy has been shown to reduce the risk of major adverse cardiovascular events (MACE) and death in patients with obstructive sleep apnea (OSA). The authors sought to investigate the long-term relationship between metabolic surgery and incident MACE in patients with OSA and obesity. Adult patients with a body mass index 35 to 70 kg/m2 and moderate-to-severe OSA at a U.S. health system (2004-2018) were identified. Baseline characteristics of patients who underwent metabolic surgery were balanced with a nonsurgical control group using overlap-weighting methods. Multivariable Cox regression analysis estimated time-to-incident MACE. Follow-up ended in September 2022. A total of 13,657 patients (7,496 [54.9%] men; mean age 52.0 ± 12.4 years; median body mass index 41.0 kg/m2 [Q1-Q3: 37.6-46.2 kg/m2]), including 970 patients in the metabolic surgery group and 12,687 patients in the nonsurgical group, with a median follow-up of 5.3 years (Q1-Q3: 3.1-8.4 years) were analyzed. The mean between-group difference in body weight at 10 years was 26.6 kg (95% CI: 25.6-27.6 kg) or 19.3% (95% CI: 18.6%-19.9%). The 10-year cumulative incidence of MACE was 27.0% (95% CI: 21.6%-32.0%) in the metabolic surgery group and 35.6% (95% CI: 33.8%-37.4%) in the nonsurgical group (adjusted HR: 0.58 [95% CI: 0.48-0.71]; P < 0.001). The 10-year cumulative incidence of all-cause mortality was 9.1% (95% CI: 5.7%-12.4%) in the metabolic surgery group and 12.5% (95% CI: 11.2%-13.8%) in the nonsurgical group (adjusted HR: 0.63 [95% CI: 0.45-0.89]; P = 0.009). Among patients with moderate-to-severe OSA and obesity, metabolic surgery, compared with nonsurgical management, was associated with a significantly lower risk of incident MACE and death. [ABSTRACT FROM AUTHOR]

Published
2024
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