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1. Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip: Insights From RESHAPE-HF2

Author

Ponikowski, Piotr, Friede, Tim, von Bardeleben, Ralph Stephan, Butler, Javed, Shahzeb Khan, Muhammad, Diek, Monika, Heinrich, Jutta, Geyer, Martin, Placzek, Marius, Ferrari, Roberto, Abraham, William T., Alfieri, Ottavio, Auricchio, Angelo, Bayes-Genis, Antoni, Cleland, John G.F., Filippatos, Gerasimos, Gustafsson, Finn, Haverkamp, Wilhelm, Kelm, Malte, Kuck, Karl-Heinz, Landmesser, Ulf, Maggioni, Aldo P., Metra, Marco, Ninios, Vlasis, Petrie, Mark C., Rassaf, Tienush, Ruschitzka, Frank, Schäfer, Ulrich, Schulze, P. Christian, Spargias, Konstantinos, Vahanian, Alec, Zamorano, Jose Luis, Zeiher, Andreas, Karakas, Mahir, Koehler, Friedrich, Lainscak, Mitja, Öner, Alper, Mezilis, Nikolaos, Theofilogiannakos, Efstratios K., Ninios, Ilias, Chrissoheris, Michael, Kourkoveli, Panagiota, Papadopoulos, Konstantinos, Smolka, Grzegorz, Wojakowski, Wojciech, Reczuch, Krzysztof, Pinto, Fausto J., Wiewiórka, Łukasz, Streb, Witold, Adamo, Marianna, Santiago-Vacas, Evelyn, Friedrich Ruf, Tobias, Gross, Michael, Tongers, Joern, Hasenfuß, Gerd, Schillinger, Wolfgang, and Anker, Stefan D.

Published
2024
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2. Percutaneous repair of moderate‐to‐severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the RESHAPE‐HF2 trial and comparison to COAPT and MITRA‐FR trials

Author

Anker, Stefan D., primary, Friede, Tim, additional, von Bardeleben, Ralph Stephan, additional, Butler, Javed, additional, Khan, Muhammad Shahzeb, additional, Diek, Monika, additional, Heinrich, Jutta, additional, Geyer, Martin, additional, Placzek, Marius, additional, Ferrari, Roberto, additional, Abraham, William T., additional, Alfieri, Ottavio, additional, Auricchio, Angelo, additional, Bayes‐Genis, Antoni, additional, Cleland, John G.F., additional, Filippatos, Gerasimos, additional, Gustafsson, Finn, additional, Haverkamp, Wilhelm, additional, Kelm, Malte, additional, Kuck, Karl‐Heinz, additional, Landmesser, Ulf, additional, Maggioni, Aldo P., additional, Metra, Marco, additional, Ninios, Vlasis, additional, Petrie, Mark C., additional, Rassaf, Tienush, additional, Ruschitzka, Frank, additional, Schäfer, Ulrich, additional, Schulze, P. Christian, additional, Spargias, Konstantinos, additional, Vahanian, Alec, additional, Zamorano, Jose Luis, additional, Zeiher, Andreas, additional, Karakas, Mahir, additional, Koehler, Friedrich, additional, Lainscak, Mitja, additional, Öner, Alper, additional, Mezilis, Nikolaos, additional, Theofilogiannakos, Efstratios K, additional, Ninios, Ilias, additional, Chrissoheris, Michael, additional, Kourkoveli, Panagiota, additional, Papadopoulos, Konstantinos, additional, Smolka, Grzegorz, additional, Wojakowski, Wojciech, additional, Reczuch, Krzysztof, additional, Pinto, Fausto J., additional, Zmudka, Krzysztof, additional, Kalarus, Zbigniew, additional, Adamo, Marianna, additional, Santiago‐Vacas, Evelyn, additional, Ruf, Tobias Friedrich, additional, Gross, Michael, additional, Tongers, Joern, additional, Hasenfuß, Gerd, additional, Schillinger, Wolfgang, additional, and Ponikowski, Piotr, additional

Published
2024
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6. Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial

Author

Abboud, Tammam, Asendorf, Thomas, Heinrich, Jutta, Faust, Katharina, Krieg, Sandro M., Seidel, Kathleen, Mielke, Dorothee, Matthies, Cordola, Ringel, Florian, Rohde, Veit, and Szelényi, Andrea

Subjects
transcranial motor-evoked potentials, QH301-705.5, intraoperative monitoring, threshold criterion, direct cortical stimulation, threshold level, 610 Medicine & health, ddc:610, Biology (General), amplitude criterion, Article
Abstract

BACKGROUND Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. METHODS This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. DISCUSSION The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other.

Published
2021
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8. The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian Syndromes

Author

Stockmann, Marianne, Meyer-Ohlendorf, Marie, Achberger, Kevin, Putz, Stefan, Demestre, Maria, Yin, Haishan, Hendrich, Corinna, Linta, Leonhard, Heinrich, Jutta, Brunner, Cornelia, Proepper, Christian, Kuh, Georges F., Baumann, Bernd, Langer, Torben, Schwalenstöcker, Birgit, Braunstein, Kerstin E., von Arnim, Christine, Schneuwly, Stephan, Meyer, Thomas, Wong, Philip C., Boeckers, Tobias M., Ludolph, Albert C., and Liebau, Stefan

Published
2013
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9. Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

Author

University of Helsinki, Department of Medical Genetics, University of Helsinki, Hospital for Children and Adolescents, Leblond, Claire S., Heinrich, Jutta, Delorme, Richard, Proepper, Christian, Betancur, Catalina, Huguet, Guillaume, Konyukh, Marina, Chaste, Pauline, Ey, Elodie, Rastam, Maria, Anckarsater, Henrik, Nygren, Gudrun, Gillberg, I. Carina, Melke, Jonas, Toro, Roberto, Regnault, Beatrice, Fauchereau, Fabien, Mercati, Oriane, Lemiere, Nathalie, Skuse, David, Poot, Martin, Holt, Richard, Monaco, Anthony P., Jarvela, Irma, Kantojärvi, Katri, Vanhala, Raija, Curran, Sarah, Collier, David A., Bolton, Patrick, Chiocchetti, Andreas, Klauck, Sabine M., Poustka, Fritz, Freitag, Christine M., Waltes, Regina, Kopp, Marnie, Duketis, Eftichia, Bacchelli, Elena, Minopoli, Fiorella, Ruta, Liliana, Battaglia, Agatino, Mazzone, Luigi, Maestrini, Elena, Sequeira, Ana F., Oliveira, Barbara, Vicente, Astrid, Oliveira, Guiomar, Pinto, Dalila, Scherer, Stephen W., Zelenika, Diana, Delepine, Marc, Lathrop, Mark, Bonneau, Dominique, Guinchat, Vincent, Devillard, Francoise, Assouline, Brigitte, Mouren, Marie-Christine, Leboyer, Marion, Gillberg, Christopher, Boeckers, Tobias M., Bourgeron, Thomas, University of Helsinki, Department of Medical Genetics, University of Helsinki, Hospital for Children and Adolescents, Leblond, Claire S., Heinrich, Jutta, Delorme, Richard, Proepper, Christian, Betancur, Catalina, Huguet, Guillaume, Konyukh, Marina, Chaste, Pauline, Ey, Elodie, Rastam, Maria, Anckarsater, Henrik, Nygren, Gudrun, Gillberg, I. Carina, Melke, Jonas, Toro, Roberto, Regnault, Beatrice, Fauchereau, Fabien, Mercati, Oriane, Lemiere, Nathalie, Skuse, David, Poot, Martin, Holt, Richard, Monaco, Anthony P., Jarvela, Irma, Kantojärvi, Katri, Vanhala, Raija, Curran, Sarah, Collier, David A., Bolton, Patrick, Chiocchetti, Andreas, Klauck, Sabine M., Poustka, Fritz, Freitag, Christine M., Waltes, Regina, Kopp, Marnie, Duketis, Eftichia, Bacchelli, Elena, Minopoli, Fiorella, Ruta, Liliana, Battaglia, Agatino, Mazzone, Luigi, Maestrini, Elena, Sequeira, Ana F., Oliveira, Barbara, Vicente, Astrid, Oliveira, Guiomar, Pinto, Dalila, Scherer, Stephen W., Zelenika, Diana, Delepine, Marc, Lathrop, Mark, Bonneau, Dominique, Guinchat, Vincent, Devillard, Francoise, Assouline, Brigitte, Mouren, Marie-Christine, Leboyer, Marion, Gillberg, Christopher, Boeckers, Tobias M., and Bourgeron, Thomas

Published
2012

10. Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of Autism spectrum disorders

Author

Leblond, Claire S., Heinrich, Jutta, Delorme, Richard, Proepper, Christian, Betancur, Catalina, Huguet, Guillaume, Konyukh, Marina, Chaste, Pauline, Ey, Elodie, Rastam, Maria, Anckarsäter, Henrik, Nygren, Gudrun, Gillberg, I. Carina, Melke, Jonas, Toro, Roberto, Regnault, Beatrice, Fauchereau, Fabien, Mercati, Oriane, Lemière, Nathalie, Skuse, David, Poot, Martin, Holt, Richard, Monaco, Anthony P., Järvelä, Irma, Kantojärvi, Katri, Vanhala, Raija, Curran, Sarah, Collier, David A., Bolton, Patrick F., Geburtig-Chiocchetti, Andreas, Klauck, Sabine M., Poustka, Fritz, Freitag, Christine M., Waltes, Regina, Kopp, Marnie, Duketis, Eftichia, Bacchelli, Elena, Minopoli, Fiorella, Ruta, Liliana, Battaglia, Agatino, Mazzone, Luigi, Maestrini, Elena, Sequeira, Ana F., Oliveira, Barbara, Vicente, Astrid M., Oliveira, Guiomar, Pinto, Dalila, Scherer, Stephen W., Zelenika, Diana, Delepine, Marc, Lathrop, Mark, Bonneau, Dominique, Guinchat, Vincent, Devillard, Françoise, Assouline, Brigitte, Mouren, Marie-Christine, Leboyer, Marion, Gillberg, Christopher, Böckers, Tobias M., Bourgeron, Thomas, Leblond, Claire S., Heinrich, Jutta, Delorme, Richard, Proepper, Christian, Betancur, Catalina, Huguet, Guillaume, Konyukh, Marina, Chaste, Pauline, Ey, Elodie, Rastam, Maria, Anckarsäter, Henrik, Nygren, Gudrun, Gillberg, I. Carina, Melke, Jonas, Toro, Roberto, Regnault, Beatrice, Fauchereau, Fabien, Mercati, Oriane, Lemière, Nathalie, Skuse, David, Poot, Martin, Holt, Richard, Monaco, Anthony P., Järvelä, Irma, Kantojärvi, Katri, Vanhala, Raija, Curran, Sarah, Collier, David A., Bolton, Patrick F., Geburtig-Chiocchetti, Andreas, Klauck, Sabine M., Poustka, Fritz, Freitag, Christine M., Waltes, Regina, Kopp, Marnie, Duketis, Eftichia, Bacchelli, Elena, Minopoli, Fiorella, Ruta, Liliana, Battaglia, Agatino, Mazzone, Luigi, Maestrini, Elena, Sequeira, Ana F., Oliveira, Barbara, Vicente, Astrid M., Oliveira, Guiomar, Pinto, Dalila, Scherer, Stephen W., Zelenika, Diana, Delepine, Marc, Lathrop, Mark, Bonneau, Dominique, Guinchat, Vincent, Devillard, Françoise, Assouline, Brigitte, Mouren, Marie-Christine, Leboyer, Marion, Gillberg, Christopher, Böckers, Tobias M., and Bourgeron, Thomas

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome Project, we identified a novel 421 kb de novo SHANK2 deletion in a patient with autism. We then sequenced SHANK2 in 455 patients with ASD and 431 controls and integrated these results with those reported by Berkel et al. 2010 (n = 396 patients and n = 659 controls). We observed a significant enrichment of variants affecting conserved amino acids in 29 of 851 (3.4%) patients and in 16 of 1,090 (1.5%) controls (P = 0.004, OR = 2.37, 95% CI = 1.23-4.70). In neuronal cell cultures, the variants identified in patients were associated with a reduced synaptic density at dendrites compared to the variants only detected in controls (P = 0.0013). Interestingly, the three patients with de novo SHANK2 deletions also carried inherited CNVs at 15q11-q13 previously associated with neuropsychiatric disorders. In two cases, the nicotinic receptor CHRNA7 was duplicated and in one case the synaptic translation repressor CYFIP1 was deleted. These results strengthen the role of synaptic gene dysfunction in ASD but also highlight the presence of putative modifier genes, which is in keeping with the "multiple hit model" for ASD. A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD.

Published
2012

11. Erinnerungen

Author

Heinrich, Jutta

Subjects
300 Sozialwissenschaften, Medien, Feminismus, ddc:300, Debatte
Published
1997
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14. The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian Syndromes

Author

Stockmann, Marianne, primary, Meyer-Ohlendorf, Marie, additional, Achberger, Kevin, additional, Putz, Stefan, additional, Demestre, Maria, additional, Yin, Haishan, additional, Hendrich, Corinna, additional, Linta, Leonhard, additional, Heinrich, Jutta, additional, Brunner, Cornelia, additional, Proepper, Christian, additional, Kuh, Georges F., additional, Baumann, Bernd, additional, Langer, Torben, additional, Schwalenstöcker, Birgit, additional, Braunstein, Kerstin E., additional, von Arnim, Christine, additional, Schneuwly, Stephan, additional, Meyer, Thomas, additional, Wong, Philip C., additional, Boeckers, Tobias M., additional, Ludolph, Albert C., additional, and Liebau, Stefan, additional

Published
2012
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15. Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

Author

Leblond, Claire S., primary, Heinrich, Jutta, additional, Delorme, Richard, additional, Proepper, Christian, additional, Betancur, Catalina, additional, Huguet, Guillaume, additional, Konyukh, Marina, additional, Chaste, Pauline, additional, Ey, Elodie, additional, Rastam, Maria, additional, Anckarsäter, Henrik, additional, Nygren, Gudrun, additional, Gillberg, I. Carina, additional, Melke, Jonas, additional, Toro, Roberto, additional, Regnault, Beatrice, additional, Fauchereau, Fabien, additional, Mercati, Oriane, additional, Lemière, Nathalie, additional, Skuse, David, additional, Poot, Martin, additional, Holt, Richard, additional, Monaco, Anthony P., additional, Järvelä, Irma, additional, Kantojärvi, Katri, additional, Vanhala, Raija, additional, Curran, Sarah, additional, Collier, David A., additional, Bolton, Patrick, additional, Chiocchetti, Andreas, additional, Klauck, Sabine M., additional, Poustka, Fritz, additional, Freitag, Christine M., additional, Waltes, Regina, additional, Kopp, Marnie, additional, Duketis, Eftichia, additional, Bacchelli, Elena, additional, Minopoli, Fiorella, additional, Ruta, Liliana, additional, Battaglia, Agatino, additional, Mazzone, Luigi, additional, Maestrini, Elena, additional, Sequeira, Ana F., additional, Oliveira, Barbara, additional, Vicente, Astrid, additional, Oliveira, Guiomar, additional, Pinto, Dalila, additional, Scherer, Stephen W., additional, Zelenika, Diana, additional, Delepine, Marc, additional, Lathrop, Mark, additional, Bonneau, Dominique, additional, Guinchat, Vincent, additional, Devillard, Françoise, additional, Assouline, Brigitte, additional, Mouren, Marie-Christine, additional, Leboyer, Marion, additional, Gillberg, Christopher, additional, Boeckers, Tobias M., additional, and Bourgeron, Thomas, additional

Published
2012
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16. Die Utopie. Die Körper

Author

Heinrich, Jutta

Subjects
Weiblichkeit, 300 Sozialwissenschaften, ddc:300, Männlichkeit, Literatur, Körper, Erfahrung, Geschlechtsspezifik, Krieg
Published
1995
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19. Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial

Author

Abboud, Tammam, Asendorf, Thomas, Heinrich, Jutta, Faust, Katharina, Krieg, Sandro M, Seidel, Kathleen, Mielke, Dorothee, Matthies, Cordola, Ringel, Florian, Rohde, Veit, and Szel��nyi, Andrea

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. METHODS This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. DISCUSSION The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other.

20. Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.

Author

Anker SD, Friede T, von Bardeleben RS, Butler J, Khan MS, Diek M, Heinrich J, Geyer M, Placzek M, Ferrari R, Abraham WT, Alfieri O, Auricchio A, Bayes-Genis A, Cleland JGF, Filippatos G, Gustafsson F, Haverkamp W, Kelm M, Kuck KH, Landmesser U, Maggioni AP, Metra M, Ninios V, Petrie MC, Rassaf T, Ruschitzka F, Schäfer U, Schulze PC, Spargias K, Vahanian A, Zamorano JL, Zeiher A, Karakas M, Koehler F, Lainscak M, Öner A, Mezilis N, Theofilogiannakos EK, Ninios I, Chrissoheris M, Kourkoveli P, Papadopoulos K, Smolka G, Wojakowski W, Reczuch K, Pinto FJ, Wiewiórka Ł, Kalarus Z, Adamo M, Santiago-Vacas E, Ruf TF, Gross M, Tongers J, Hasenfuss G, Schillinger W, and Ponikowski P

Subjects
Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Combined Modality Therapy, Kaplan-Meier Estimate, Severity of Illness Index, Recurrence, Cardiac Catheterization adverse effects, Cardiac Catheterization instrumentation, Cardiac Catheterization methods, Heart Failure complications, Heart Failure diagnosis, Heart Failure mortality, Heart Failure therapy, Hospitalization statistics & numerical data, Mitral Valve surgery, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency etiology, Mitral Valve Insufficiency mortality, Mitral Valve Insufficiency therapy
Abstract

Background: Whether transcatheter mitral-valve repair improves outcomes in patients with heart failure and functional mitral regurgitation is uncertain., Methods: We conducted a randomized, controlled trial involving patients with heart failure and moderate to severe functional mitral regurgitation from 30 sites in nine countries. The patients were assigned in a 1:1 ratio to either transcatheter mitral-valve repair and guideline-recommended medical therapy (device group) or medical therapy alone (control group). The three primary end points were the rate of the composite of first or recurrent hospitalization for heart failure or cardiovascular death during 24 months; the rate of first or recurrent hospitalization for heart failure during 24 months; and the change from baseline to 12 months in the score on the Kansas City Cardiomyopathy Questionnaire-Overall Summary (KCCQ-OS; scores range from 0 to 100, with higher scores indicating better health status)., Results: A total of 505 patients underwent randomization: 250 were assigned to the device group and 255 to the control group. At 24 months, the rate of first or recurrent hospitalization for heart failure or cardiovascular death was 37.0 events per 100 patient-years in the device group and 58.9 events per 100 patient-years in the control group (rate ratio, 0.64; 95% confidence interval [CI], 0.48 to 0.85; P = 0.002). The rate of first or recurrent hospitalization for heart failure was 26.9 events per 100 patient-years in the device group and 46.6 events per 100 patient-years in the control group (rate ratio, 0.59; 95% CI, 0.42 to 0.82; P = 0.002). The KCCQ-OS score increased by a mean (±SD) of 21.6±26.9 points in the device group and 8.0±24.5 points in the control group (mean difference, 10.9 points; 95% CI, 6.8 to 15.0; P<0.001). Device-specific safety events occurred in 4 patients (1.6%)., Conclusions: Among patients with heart failure with moderate to severe functional mitral regurgitation who received medical therapy, the addition of transcatheter mitral-valve repair led to a lower rate of first or recurrent hospitalization for heart failure or cardiovascular death and a lower rate of first or recurrent hospitalization for heart failure at 24 months and better health status at 12 months than medical therapy alone. (Funded by Abbott Laboratories; RESHAPE-HF2 ClinicalTrials.gov number, NCT02444338.)., (Copyright © 2024 Massachusetts Medical Society.)

Published
2024
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