Author: "Heinrich, J (Joachim)" - Searchworks@Jio Institute Digital Library Search Results

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1. Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms

Author: Jami, E. S. (Eshim S.), Hammerschlag, A. R. (Anke R.), Ip, H. F. (Hill F.), Allegrini, A. G. (Andrea G.), Benyamin, B. (Beben), Border, R. (Richard), Diemer, E. W. (Elizabeth W.), Jiang, C. (Chang), Karhunen, V. (Ville), Lu, Y. (Yi), Lu, Q. (Qing), Mallard, T. T. (Travis T.), Mishra, P. P. (Pashupati P.), Nolte, I. M. (Ilja M.), Palviainen, T. (Teemu), Peterson, R. E. (Roseann E.), Sallis, H. M. (Hannah M.), Shabalin, A. A. (Andrey A.), Tate, A. E. (Ashley E.), Thiering, E. (Elisabeth), Vilor-Tejedor, N. (Natalia), Wang, C. (Carol), Zhou, A. (Ang), Adkins, D. E. (Daniel E.), Alemany, S. (Silvia), Ask, H. (Helga), Chen, Q. (Qi), Corley, R. P. (Robin P.), Ehli, E. A. (Erik A.), Evans, L. M. (Luke M.), Havdahl, A. (Alexandra), Hagenbeek, F. A. (Fiona A.), Hakulinen, C. (Christian), Henders, A. K. (Anjali K.), Hottenga, J. J. (Jouke Jan), Korhonen, T. (Tellervo), Mamun, A. (Abdullah), Marrington, S. (Shelby), Neumann, A. (Alexander), Rimfeld, K. (Kaili), Rivadeneira, F. (Fernando), Silberg, J. L. (Judy L.), van Beijsterveldt, C. E. (Catharina E.), Vuoksimaa, E. (Eero), Whipp, A. M. (Alyce M.), Tong, X. (Xiaoran), Andreassen, O. A. (Ole A.), Boomsma, D. I. (Dorret, I), Brown, S. A. (Sandra A.), Burt, S. A. (S. Alexandra), Copeland, W. (William), Dick, D. M. (Danielle M.), Harden, K. P. (K. Paige), Harris, K. M. (Kathleen Mullan), Hartman, C. A. (Catharina A.), Heinrich, J. (Joachim), Hewitt, J. K. (John K.), Hopfer, C. (Christian), Hypponen, E. (Elina), Järvelin, M.-R. (Marjo-Riitta), Kaprio, J. (Jaakko), Keltikangas-Jarvinen, L. (Liisa), Klump, K. L. (Kelly L.), Krauter, K. (Kenneth), Kuja-Halkola, R. (Ralf), Larsson, H. (Henrik), Lehtimaki, T. (Terho), Lichtenstein, P. (Paul), Lundstrom, S. (Sebastian), Maes, H. H. (Hermine H.), Magnus, P. (Per), Munafo, M. R. (Marcus R.), Najman, J. M. (Jake M.), Njolstad, P. R. (Pal R.), Oldehinkel, A. J. (Albertine J.), Pennell, C. E. (Craig E.), Plomin, R. (Robert), Reichborn-Kjennerud, T. (Ted), Reynolds, C. (Chandra), Rose, R. J. (Richard J.), Smolen, A. (Andrew), Snieder, H. (Harold), Stallings, M. (Michael), Standl, M. (Marie), Sunyer, J. (Jordi), Tiemeier, H. (Henning), Wadsworth, S. J. (Sally J.), Wall, T. L. (Tamara L.), Whitehouse, A. J. (Andrew J. O.), Williams, G. M. (Gail M.), Ystrom, E. (Eivind), Nivard, M. G. (Michel G.), Bartels, M. (Meike), Middeldorp, C. M. (Christel M.), Jami, E. S. (Eshim S.), Hammerschlag, A. R. (Anke R.), Ip, H. F. (Hill F.), Allegrini, A. G. (Andrea G.), Benyamin, B. (Beben), Border, R. (Richard), Diemer, E. W. (Elizabeth W.), Jiang, C. (Chang), Karhunen, V. (Ville), Lu, Y. (Yi), Lu, Q. (Qing), Mallard, T. T. (Travis T.), Mishra, P. P. (Pashupati P.), Nolte, I. M. (Ilja M.), Palviainen, T. (Teemu), Peterson, R. E. (Roseann E.), Sallis, H. M. (Hannah M.), Shabalin, A. A. (Andrey A.), Tate, A. E. (Ashley E.), Thiering, E. (Elisabeth), Vilor-Tejedor, N. (Natalia), Wang, C. (Carol), Zhou, A. (Ang), Adkins, D. E. (Daniel E.), Alemany, S. (Silvia), Ask, H. (Helga), Chen, Q. (Qi), Corley, R. P. (Robin P.), Ehli, E. A. (Erik A.), Evans, L. M. (Luke M.), Havdahl, A. (Alexandra), Hagenbeek, F. A. (Fiona A.), Hakulinen, C. (Christian), Henders, A. K. (Anjali K.), Hottenga, J. J. (Jouke Jan), Korhonen, T. (Tellervo), Mamun, A. (Abdullah), Marrington, S. (Shelby), Neumann, A. (Alexander), Rimfeld, K. (Kaili), Rivadeneira, F. (Fernando), Silberg, J. L. (Judy L.), van Beijsterveldt, C. E. (Catharina E.), Vuoksimaa, E. (Eero), Whipp, A. M. (Alyce M.), Tong, X. (Xiaoran), Andreassen, O. A. (Ole A.), Boomsma, D. I. (Dorret, I), Brown, S. A. (Sandra A.), Burt, S. A. (S. Alexandra), Copeland, W. (William), Dick, D. M. (Danielle M.), Harden, K. P. (K. Paige), Harris, K. M. (Kathleen Mullan), Hartman, C. A. (Catharina A.), Heinrich, J. (Joachim), Hewitt, J. K. (John K.), Hopfer, C. (Christian), Hypponen, E. (Elina), Järvelin, M.-R. (Marjo-Riitta), Kaprio, J. (Jaakko), Keltikangas-Jarvinen, L. (Liisa), Klump, K. L. (Kelly L.), Krauter, K. (Kenneth), Kuja-Halkola, R. (Ralf), Larsson, H. (Henrik), Lehtimaki, T. (Terho), Lichtenstein, P. (Paul), Lundstrom, S. (Sebastian), Maes, H. H. (Hermine H.), Magnus, P. (Per), Munafo, M. R. (Marcus R.), Najman, J. M. (Jake M.), Njolstad, P. R. (Pal R.), Oldehinkel, A. J. (Albertine J.), Pennell, C. E. (Craig E.), Plomin, R. (Robert), Reichborn-Kjennerud, T. (Ted), Reynolds, C. (Chandra), Rose, R. J. (Richard J.), Smolen, A. (Andrew), Snieder, H. (Harold), Stallings, M. (Michael), Standl, M. (Marie), Sunyer, J. (Jordi), Tiemeier, H. (Henning), Wadsworth, S. J. (Sally J.), Wall, T. L. (Tamara L.), Whitehouse, A. J. (Andrew J. O.), Williams, G. M. (Gail M.), Ystrom, E. (Eivind), Nivard, M. G. (Michel G.), Bartels, M. (Meike), and Middeldorp, C. M. (Christel M.)
Abstract: Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. Results: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84–2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%–8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| < 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42–0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.
Published: 2022

2. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Author: Vogelezang, S. (Suzanne), Bradfield, J. P. (Jonathan P.), Ahluwalia, T. S. (Tarunveer S.), Curtin, J. A. (John A.), Lakka, T. A. (Timo A.), Grarup, N. (Niels), Scholz, M. (Markus), van der Most, P. J. (Peter J.), Monnereau, C. (Claire), Stergiakouli, E. (Evie), Heiskala, A. (Anni), Horikoshi, M. (Momoko), Fedko, I. O. (Iryna O.), Vilor-Tejedor, N. (Natalia), Cousminer, D. L. (Diana L.), Standl, M. (Marie), Wang, C. A. (Carol A.), Viikari, J. (Jorma), Geller, F. (Frank), iniguez, C. (Carmen), Pitkanen, N. (Niina), Chesi, A. (Alessandra), Bacelis, J. (Jonas), Yengo, L. (Loic), Torrent, M. (Maties), Ntalla, I. (Ioanna), Helgeland, O. (Oyvind), Selzam, S. (Saskia), Vonk, J. M. (Judith M.), Zafarmand, M. H. (Mohammed H.), Heude, B. (Barbara), Farooqi, I. S. (Ismaa Sadaf), Alyass, A. (Akram), Beaumont, R. N. (Robin N.), Have, C. T. (Christian T.), Rzehak, P. (Peter), Bilbao, J. R. (Jose Ramon), Schnurr, T. M. (Theresia M.), Barroso, I. (Ines), Bonnelykke, K. (Klaus), Beilin, L. J. (Lawrence J.), Carstensen, L. (Lisbeth), Charles, M.-A. (Marie-Aline), Chawes, B. (Bo), Clement, K. (Karine), Closa-Monasterolo, R. (Ricardo), Custovic, A. (Adnan), Eriksson, J. G. (Johan G.), Escribano, J. (Joaquin), Groen-Blokhuis, M. (Maria), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Hakonarson, H. (Hakon), Hansen, T. (Torben), Hattersley, A. T. (Andrew T.), Hollensted, M. (Mette), Hottenga, J.-J. (Jouke-Jan), Hypponen, E. (Elina), Johansson, S. (Stefan), Joro, R. (Raimo), Kahonen, M. (Mika), Karhunen, V. (Ville), Kiess, W. (Wieland), Knight, B. A. (Bridget A.), Koletzko, B. (Berthold), Kuehnapfel, A. (Andreas), Landgraf, K. (Kathrin), Langhendries, J.-P. (Jean-Paul), Lehtimaki, T. (Terho), Leinonen, J. T. (Jaakko T.), Li, A. (Aihuali), Lindi, V. (Virpi), Lowry, E. (Estelle), Bustamante, M. (Mariona), Medina-Gomez, C. (Carolina), Melbye, M. (Mads), Michaelsen, K. F. (Kim F.), Morgen, C. S. (Camilla S.), Mori, T. A. (Trevor A.), Nielsen, T. R. (Tenna R. H.), Niinikoski, H. (Harri), Oldehinkel, A. J. (Albertine J.), Pahkala, K. (Katja), Panoutsopoulou, K. (Kalliope), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Power, C. (Christine), Reijneveld, S. A. (Sijmen A.), Rivadeneira, F. (Fernando), Simpson, A. (Angela), Sly, P. D. (Peter D.), Stokholm, J. (Jakob), Teo, K. K. (Kook K.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Uitterlinden, A. G. (Andre G.), van Beijsterveldt, C. E. (Catharina E. M.), van Schaik, B. D. (Barbera D. C.), Vaudel, M. (Marc), Verduci, E. (Elvira), Vinding, R. K. (Rebecca K.), Vogel, M. (Mandy), Zeggini, E. (Eleftheria), Sebert, S. (Sylvain), Lind, M. V. (Mads V.), Brown, C. D. (Christopher D.), Santa-Marina, L. (Loreto), Reischl, E. (Eva), Frithioff-Bojsoe, C. (Christine), Meyre, D. (David), Wheeler, E. (Eleanor), Ong, K. (Ken), Nohr, E. A. (Ellen A.), Vrijkotte, T. G. (Tanja G. M.), Koppelman, G. H. (Gerard H.), Plomin, R. (Robert), Njolstad, P. R. (Pal R.), Dedoussis, G. D. (George D.), Froguel, P. (Philippe), Sorensen, T. I. (Thorkild I. A.), Jacobsson, B. (Bo), Freathy, R. M. (Rachel M.), Zemel, B. S. (Babette S.), Raitakari, O. (Olli), Vrijheid, M. (Martine), Feenstra, B. (Bjarke), Lyytikainen, L.-P. (Leo-Pekka), Snieder, H. (Harold), Kirsten, H. (Holger), Holt, P. G. (Patrick G.), Heinrich, J. (Joachim), Widen, E. (Elisabeth), Sunyer, J. (Jordi), Boomsma, D. I. (Dorret I.), Jarvelin, M.-R. (Marjo-Riitta), Koerner, A. (Antje), Davey Smith, G. (George), Holm, J.-C. (Jens-Christian), Atalay, M. (Mustafa), Murray, C. (Clare), Bisgaard, H. (Hans), McCarthy, M. I. (Mark I.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), Felix, J. F. (Janine F.), Vogelezang, S. (Suzanne), Bradfield, J. P. (Jonathan P.), Ahluwalia, T. S. (Tarunveer S.), Curtin, J. A. (John A.), Lakka, T. A. (Timo A.), Grarup, N. (Niels), Scholz, M. (Markus), van der Most, P. J. (Peter J.), Monnereau, C. (Claire), Stergiakouli, E. (Evie), Heiskala, A. (Anni), Horikoshi, M. (Momoko), Fedko, I. O. (Iryna O.), Vilor-Tejedor, N. (Natalia), Cousminer, D. L. (Diana L.), Standl, M. (Marie), Wang, C. A. (Carol A.), Viikari, J. (Jorma), Geller, F. (Frank), iniguez, C. (Carmen), Pitkanen, N. (Niina), Chesi, A. (Alessandra), Bacelis, J. (Jonas), Yengo, L. (Loic), Torrent, M. (Maties), Ntalla, I. (Ioanna), Helgeland, O. (Oyvind), Selzam, S. (Saskia), Vonk, J. M. (Judith M.), Zafarmand, M. H. (Mohammed H.), Heude, B. (Barbara), Farooqi, I. S. (Ismaa Sadaf), Alyass, A. (Akram), Beaumont, R. N. (Robin N.), Have, C. T. (Christian T.), Rzehak, P. (Peter), Bilbao, J. R. (Jose Ramon), Schnurr, T. M. (Theresia M.), Barroso, I. (Ines), Bonnelykke, K. (Klaus), Beilin, L. J. (Lawrence J.), Carstensen, L. (Lisbeth), Charles, M.-A. (Marie-Aline), Chawes, B. (Bo), Clement, K. (Karine), Closa-Monasterolo, R. (Ricardo), Custovic, A. (Adnan), Eriksson, J. G. (Johan G.), Escribano, J. (Joaquin), Groen-Blokhuis, M. (Maria), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Hakonarson, H. (Hakon), Hansen, T. (Torben), Hattersley, A. T. (Andrew T.), Hollensted, M. (Mette), Hottenga, J.-J. (Jouke-Jan), Hypponen, E. (Elina), Johansson, S. (Stefan), Joro, R. (Raimo), Kahonen, M. (Mika), Karhunen, V. (Ville), Kiess, W. (Wieland), Knight, B. A. (Bridget A.), Koletzko, B. (Berthold), Kuehnapfel, A. (Andreas), Landgraf, K. (Kathrin), Langhendries, J.-P. (Jean-Paul), Lehtimaki, T. (Terho), Leinonen, J. T. (Jaakko T.), Li, A. (Aihuali), Lindi, V. (Virpi), Lowry, E. (Estelle), Bustamante, M. (Mariona), Medina-Gomez, C. (Carolina), Melbye, M. (Mads), Michaelsen, K. F. (Kim F.), Morgen, C. S. (Camilla S.), Mori, T. A. (Trevor A.), Nielsen, T. R. (Tenna R. H.), Niinikoski, H. (Harri), Oldehinkel, A. J. (Albertine J.), Pahkala, K. (Katja), Panoutsopoulou, K. (Kalliope), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Power, C. (Christine), Reijneveld, S. A. (Sijmen A.), Rivadeneira, F. (Fernando), Simpson, A. (Angela), Sly, P. D. (Peter D.), Stokholm, J. (Jakob), Teo, K. K. (Kook K.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Uitterlinden, A. G. (Andre G.), van Beijsterveldt, C. E. (Catharina E. M.), van Schaik, B. D. (Barbera D. C.), Vaudel, M. (Marc), Verduci, E. (Elvira), Vinding, R. K. (Rebecca K.), Vogel, M. (Mandy), Zeggini, E. (Eleftheria), Sebert, S. (Sylvain), Lind, M. V. (Mads V.), Brown, C. D. (Christopher D.), Santa-Marina, L. (Loreto), Reischl, E. (Eva), Frithioff-Bojsoe, C. (Christine), Meyre, D. (David), Wheeler, E. (Eleanor), Ong, K. (Ken), Nohr, E. A. (Ellen A.), Vrijkotte, T. G. (Tanja G. M.), Koppelman, G. H. (Gerard H.), Plomin, R. (Robert), Njolstad, P. R. (Pal R.), Dedoussis, G. D. (George D.), Froguel, P. (Philippe), Sorensen, T. I. (Thorkild I. A.), Jacobsson, B. (Bo), Freathy, R. M. (Rachel M.), Zemel, B. S. (Babette S.), Raitakari, O. (Olli), Vrijheid, M. (Martine), Feenstra, B. (Bjarke), Lyytikainen, L.-P. (Leo-Pekka), Snieder, H. (Harold), Kirsten, H. (Holger), Holt, P. G. (Patrick G.), Heinrich, J. (Joachim), Widen, E. (Elisabeth), Sunyer, J. (Jordi), Boomsma, D. I. (Dorret I.), Jarvelin, M.-R. (Marjo-Riitta), Koerner, A. (Antje), Davey Smith, G. (George), Holm, J.-C. (Jens-Christian), Atalay, M. (Mustafa), Murray, C. (Clare), Bisgaard, H. (Hans), McCarthy, M. I. (Mark I.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), and Felix, J. F. (Janine F.)
Abstract: The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Published: 2020

3. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Author: Alves, A. C. (Alexessander Couto), De Silva, N. M. (N. Maneka G.), Karhunen, V. (Ville), Sovio, U. (Ulla), Das, S. (Shikta), Taal, H. R. (H. Rob), Warrington, N. M. (Nicole M.), Lewin, A. M. (Alexandra M.), Kaakinen, M. (Marika), Cousminer, D. L. (Diana L.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Bond, T. A. (Tom A.), Lowry, E. (Estelle), Brown, C. D. (Christopher D.), Estivill, X. (Xavier), Lindi, V. (Virpi), Bradfield, J. P. (Jonathan P.), Geller, F. (Frank), Speed, D. (Doug), Coin, L. J. (Lachlan J. M.), Loh, M. (Marie), Barton, S. J. (Sheila J.), Beilin, L. J. (Lawrence J.), Bisgaard, H. (Hans), Bonnelykke, K. (Klaus), Alili, R. (Rohia), Hatoum, I. J. (Ida J.), Schramm, K. (Katharina), Cartwright, R. (Rufus), Charles, M.-A. (Marie-Aline), Salerno, V. (Vincenzo), Clement, K. (Karine), Claringbould, A. A. (Annique A. J.), van Duijn, C. M. (Cornelia M.), Moltchanova, E. (Elena), Eriksson, J. G. (Johan G.), Elks, C. (Cathy), Feenstra, B. (Bjarke), Flexeder, C. (Claudia), Franks, S. (Stephen), Frayling, T. M. (Timothy M.), Freathy, R. M. (Rachel M.), Elliott, P. (Paul), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Hattersley, A. T. (Andrew T.), Rodriguez, A. (Alina), Banterle, M. (Marco), Heinrich, J. (Joachim), Heude, B. (Barbara), Holloway, J. W. (John W.), Hofman, A. (Albert), Hypponen, E. (Elina), Inskip, H. (Hazel), Kaplan, L. M. (Lee M.), Hedman, A. K. (Asa K.), Läärä, E. (Esa), Prokisch, H. (Holger), Grallert, H. (Harald), Lakka, T. A. (Timo A.), Lawlor, D. A. (Debbie A.), Melbye, M. (Mads), Ahluwalia, T. S. (Tarunveer S.), Marinelli, M. (Marcella), Millwood, I. Y. (Iona Y.), Palmer, L. J. (Lyle J.), Pennell, C. E. (Craig E.), Perry, J. R. (John R.), Ring, S. M. (Susan M.), Savolainen, M. J. (Markku J.), Rivadeneira, F. (Fernando), Standl, M. (Marie), Sunyer, J. (Jordi), Tiesler, C. M. (Carla M. T.), Uitterlinden, A. G. (Andre G.), Schierding, W. (William), O'Sullivan, J. M. (Justin M.), Prokopenko, I. (Inga), Herzig, K.-H. (Karl-Heinz), Smith, G. D. (George Davey), O'Reilly, P. (Paul), Felix, J. F. (Janine F.), Buxton, J. L. (Jessica L.), Blakemore, A. I. (Alexandra I. F.), Ong, K. K. (Ken K.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), Sebert, S. (Sylvain), McCarthy, M. I. (Mark I.), Jarvelin, M.-R. (Marjo-Riitta), Alves, A. C. (Alexessander Couto), De Silva, N. M. (N. Maneka G.), Karhunen, V. (Ville), Sovio, U. (Ulla), Das, S. (Shikta), Taal, H. R. (H. Rob), Warrington, N. M. (Nicole M.), Lewin, A. M. (Alexandra M.), Kaakinen, M. (Marika), Cousminer, D. L. (Diana L.), Thiering, E. (Elisabeth), Timpson, N. J. (Nicholas J.), Bond, T. A. (Tom A.), Lowry, E. (Estelle), Brown, C. D. (Christopher D.), Estivill, X. (Xavier), Lindi, V. (Virpi), Bradfield, J. P. (Jonathan P.), Geller, F. (Frank), Speed, D. (Doug), Coin, L. J. (Lachlan J. M.), Loh, M. (Marie), Barton, S. J. (Sheila J.), Beilin, L. J. (Lawrence J.), Bisgaard, H. (Hans), Bonnelykke, K. (Klaus), Alili, R. (Rohia), Hatoum, I. J. (Ida J.), Schramm, K. (Katharina), Cartwright, R. (Rufus), Charles, M.-A. (Marie-Aline), Salerno, V. (Vincenzo), Clement, K. (Karine), Claringbould, A. A. (Annique A. J.), van Duijn, C. M. (Cornelia M.), Moltchanova, E. (Elena), Eriksson, J. G. (Johan G.), Elks, C. (Cathy), Feenstra, B. (Bjarke), Flexeder, C. (Claudia), Franks, S. (Stephen), Frayling, T. M. (Timothy M.), Freathy, R. M. (Rachel M.), Elliott, P. (Paul), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Hattersley, A. T. (Andrew T.), Rodriguez, A. (Alina), Banterle, M. (Marco), Heinrich, J. (Joachim), Heude, B. (Barbara), Holloway, J. W. (John W.), Hofman, A. (Albert), Hypponen, E. (Elina), Inskip, H. (Hazel), Kaplan, L. M. (Lee M.), Hedman, A. K. (Asa K.), Läärä, E. (Esa), Prokisch, H. (Holger), Grallert, H. (Harald), Lakka, T. A. (Timo A.), Lawlor, D. A. (Debbie A.), Melbye, M. (Mads), Ahluwalia, T. S. (Tarunveer S.), Marinelli, M. (Marcella), Millwood, I. Y. (Iona Y.), Palmer, L. J. (Lyle J.), Pennell, C. E. (Craig E.), Perry, J. R. (John R.), Ring, S. M. (Susan M.), Savolainen, M. J. (Markku J.), Rivadeneira, F. (Fernando), Standl, M. (Marie), Sunyer, J. (Jordi), Tiesler, C. M. (Carla M. T.), Uitterlinden, A. G. (Andre G.), Schierding, W. (William), O'Sullivan, J. M. (Justin M.), Prokopenko, I. (Inga), Herzig, K.-H. (Karl-Heinz), Smith, G. D. (George Davey), O'Reilly, P. (Paul), Felix, J. F. (Janine F.), Buxton, J. L. (Jessica L.), Blakemore, A. I. (Alexandra I. F.), Ong, K. K. (Ken K.), Jaddoe, V. W. (Vincent W. V.), Grant, S. F. (Struan F. A.), Sebert, S. (Sylvain), McCarthy, M. I. (Mark I.), and Jarvelin, M.-R. (Marjo-Riitta)
Abstract: Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
Published: 2019

4. Erratum to: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Author: Waage, J. (Johannes), Standl, M. (Marie), Curtin, J.A. (John), Jessen, L.E. (Leon E.), Thorsen, J. (Jonathan), Tian, C. (Chao), Schoettler, N. (Nathan), Flores, C. (Carlos), Abdellaoui, A. (Abdel), Ahluwalia, T.S. (Tarunveer Singh), Alves, A.C. (Alexessander Couto), Amaral, A.F.S. (André), Anto, J.M. (Josep), Barreto-Luis, A. (Amalia), Baurecht, H. (Hansjörg), Beijsterveldt, C.E.M. (Toos) van, Bleecker, E.R. (E.), Bonàs-Guarch, S. (Silvia), Boomsma, D.I. (Dorret), Brix, S. (Susanne), Bunyavanich, S. (Supinda), Burchard, E.G. (Esteban), Chen, Z. (Zhanghua), Curjuric, I. (Ivan), Custovic, A. (Adnan), Dekker, H.T. (Herman) den, Dharmage, S.C. (Shyamali C.), Dmitrieva, J. (Julia), Duijts, L. (Liesbeth), Ege, M. (Markus), Gauderman, W.J. (W James), Georges, M. (Michel), Gieger, C. (Christian), Gilliland, D.G. (Gary), Granell, R. (Raquel), Gui, H. (Hongsheng), Hansen, T. (Torben), Heinrich, J. (Joachim), Henderson, J. (John), Hernandez-Pacheco, N. (Natalia), Holt, P.G. (Patrick), Imboden, M. (Medea), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), Jarvis, D.L. (Deborah), Jensen, K.K. (Kamilla K.), Jonsdottir, I. (Ingileif), Kabesch, M. (Michael), Kaprio, J. (Jaakko), Kumar, A. (Ashish), Lee, Y.-A. (Young-Ae), Levin, A.M. (Albert M.), Li, X. (Xingnan), Lorenzo-Diaz, F. (Fabian), Melén, E. (Erik), Mercader, J.M. (Josep M.), Meyers, D.A. (Deborah A.), Myers, R.A. (Rachel A.), Nicolae, D. (Dan), Nohr, C. (Christian), Palviainen, T. (Teemu), Paternoster, L. (Lavinia), Pennell, C.E. (Craig E.), Pershagen, G. (Göran), Pino-Yanes, M. (Maria), Probst-Hensch, N.M. (Nicole M.), Rüschendorf, F. (Franz), Simpson, A. (Angela), Zwart, J-A. (John-Anker), Sunyer, J. (Jordi), Sveinbjornsson, G. (Gardar), Thiering, E. (Elisabeth), Thompson, P.J. (Philip J.), Torrent, M. (Maties), Torrents, D. (David), Tung, J.Y. (Joyce Y.), Wang, C.A. (Carol A.), Weidinger, S. (Stephan), Weiss, S.T. (Scott T.), Willemsen, G.A.H.M. (Gonneke), Williams, L.K. (L. Keoki), Ober, C. (Carole), Hinds, D.A. (David A.), Ferreira, M.A. (Manuel), Bisgaard, H. (Hans), Arnold, A.M. (Alice), Strachan, D.P. (David), Bønnelykke, K. (Klaus), Waage, J. (Johannes), Standl, M. (Marie), Curtin, J.A. (John), Jessen, L.E. (Leon E.), Thorsen, J. (Jonathan), Tian, C. (Chao), Schoettler, N. (Nathan), Flores, C. (Carlos), Abdellaoui, A. (Abdel), Ahluwalia, T.S. (Tarunveer Singh), Alves, A.C. (Alexessander Couto), Amaral, A.F.S. (André), Anto, J.M. (Josep), Barreto-Luis, A. (Amalia), Baurecht, H. (Hansjörg), Beijsterveldt, C.E.M. (Toos) van, Bleecker, E.R. (E.), Bonàs-Guarch, S. (Silvia), Boomsma, D.I. (Dorret), Brix, S. (Susanne), Bunyavanich, S. (Supinda), Burchard, E.G. (Esteban), Chen, Z. (Zhanghua), Curjuric, I. (Ivan), Custovic, A. (Adnan), Dekker, H.T. (Herman) den, Dharmage, S.C. (Shyamali C.), Dmitrieva, J. (Julia), Duijts, L. (Liesbeth), Ege, M. (Markus), Gauderman, W.J. (W James), Georges, M. (Michel), Gieger, C. (Christian), Gilliland, D.G. (Gary), Granell, R. (Raquel), Gui, H. (Hongsheng), Hansen, T. (Torben), Heinrich, J. (Joachim), Henderson, J. (John), Hernandez-Pacheco, N. (Natalia), Holt, P.G. (Patrick), Imboden, M. (Medea), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), Jarvis, D.L. (Deborah), Jensen, K.K. (Kamilla K.), Jonsdottir, I. (Ingileif), Kabesch, M. (Michael), Kaprio, J. (Jaakko), Kumar, A. (Ashish), Lee, Y.-A. (Young-Ae), Levin, A.M. (Albert M.), Li, X. (Xingnan), Lorenzo-Diaz, F. (Fabian), Melén, E. (Erik), Mercader, J.M. (Josep M.), Meyers, D.A. (Deborah A.), Myers, R.A. (Rachel A.), Nicolae, D. (Dan), Nohr, C. (Christian), Palviainen, T. (Teemu), Paternoster, L. (Lavinia), Pennell, C.E. (Craig E.), Pershagen, G. (Göran), Pino-Yanes, M. (Maria), Probst-Hensch, N.M. (Nicole M.), Rüschendorf, F. (Franz), Simpson, A. (Angela), Zwart, J-A. (John-Anker), Sunyer, J. (Jordi), Sveinbjornsson, G. (Gardar), Thiering, E. (Elisabeth), Thompson, P.J. (Philip J.), Torrent, M. (Maties), Torrents, D. (David), Tung, J.Y. (Joyce Y.), Wang, C.A. (Carol A.), Weidinger, S. (Stephan), Weiss, S.T. (Scott T.), Willemsen, G.A.H.M. (Gonneke), Williams, L.K. (L. Keoki), Ober, C. (Carole), Hinds, D.A. (David A.), Ferreira, M.A. (Manuel), Bisgaard, H. (Hans), Arnold, A.M. (Alice), Strachan, D.P. (David), and Bønnelykke, K. (Klaus)
Abstract: In the version of this article initially published, in Fig. 3, the _y_-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article.
Published: 2018
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5. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Author: Waage, J. (Johannes), Standl, M. (Marie), Curtin, J. A. (John A.), Jessen, L. E. (Leon E.), Thorsen, J. (Jonathan), Tian, C. (Chao), Schoettler, N. (Nathan), Flores, C. (Carlos), Abdellaoui, A. (Abdel), Ahluwalia, T. S. (Tarunveer S.), Alves, A. C. (Alexessander C.), Amaral, A. F. (Andre F. S.), Anto, J. M. (Josep M.), Arnold, A. (Andreas), Barreto-Luis, A. (Amalia), Baurecht, H. (Hansjoerg), van Beijsterveldt, C. E. (Catharina E. M.), Bleecker, E. R. (Eugene R.), Bonas-Guarch, S. (Silvia), Boomsman, D. I. (Dorret I.), Brix, S. (Susanne), Bunyavanich, S. (Supinda), Burchard, E. G. (Esteban G.), Chen, Z. (Zhanghua), Curjuric, I. (Ivan), Custovic, A. (Adnan), den Dekker, H. T. (Herman T.), Dharmage, S. C. (Shyamali C.), Dmitrieva, J. (Julia), Duijts, L. (Liesbeth), Ege, M. J. (Markus J.), Gauderman, W. J. (W. James), Georges, M. (Michel), Gieger, C. (Christian), Gilliland, F. (Frank), Granell, R. (Raquel), Gui, H. (Hongsheng), Hansen, T. (Torben), Heinrich, J. (Joachim), Henderson, J. (John), Hernandez-Pacheco, N. (Natalia), Holt, P. (Patrick), Imboden, M. (Medea), Jaddoe, V. W. (Vincent W. V.), Järvelin, M.-R. (Marjo-Riitta), Jarvis, D. L. (Deborah L.), Jensen, K. K. (Kamilla K.), Jonsdottir, I. (Ingileif), Kabesch, M. (Michael), Kaprio, J. (Jaakko), Kumar, A. (Ashish), Lee, Y.-A. (Young-Ae), Levin, A. M. (Albert M.), Li, X. (Xingnan), Lorenzo-Diaz, F. (Fabian), Melen, E. (Erik), Mercader, J. M. (Josep M.), Meyers, D. A. (Deborah A.), Myers, R. (Rachel), Nicolae, D. L. (Dan L.), Nohr, E. A. (Ellen A.), Palviainen, T. (Teemu), Paternoster, L. (Lavinia), Pennell, C. E. (Craig E.), Pershagen, G. (Goran), Pino-Yanes, M. (Maria), Probst-Hensch, N. M. (Nicole M.), Ruschendorf, F. (Franz), Simpson, A. (Angela), Stefansson, K. (Kari), Sunyer, J. (Jordi), Sveinbjornsson, G. (Gardar), Thiering, E. (Elisabeth), Thompson, P. J. (Philip J.), Torrent, M. (Maties), Torrents, D. (David), Tung, J. Y. (Joyce Y.), Wang, C. A. (Carol A.), Weidinger, S. (Stephan), Weiss, S. (Scott), Willemsen, G. (Gonneke), Williams, L. K. (L. Keoki), Ober, C. (Carole), Hinds, D. A. (David A.), Ferreira, M. A. (Manuel A.), Bisgaard, H. (Hans), Strachan, D. P. (David P.), Bonnelykke, K. (Klaus), Waage, J. (Johannes), Standl, M. (Marie), Curtin, J. A. (John A.), Jessen, L. E. (Leon E.), Thorsen, J. (Jonathan), Tian, C. (Chao), Schoettler, N. (Nathan), Flores, C. (Carlos), Abdellaoui, A. (Abdel), Ahluwalia, T. S. (Tarunveer S.), Alves, A. C. (Alexessander C.), Amaral, A. F. (Andre F. S.), Anto, J. M. (Josep M.), Arnold, A. (Andreas), Barreto-Luis, A. (Amalia), Baurecht, H. (Hansjoerg), van Beijsterveldt, C. E. (Catharina E. M.), Bleecker, E. R. (Eugene R.), Bonas-Guarch, S. (Silvia), Boomsman, D. I. (Dorret I.), Brix, S. (Susanne), Bunyavanich, S. (Supinda), Burchard, E. G. (Esteban G.), Chen, Z. (Zhanghua), Curjuric, I. (Ivan), Custovic, A. (Adnan), den Dekker, H. T. (Herman T.), Dharmage, S. C. (Shyamali C.), Dmitrieva, J. (Julia), Duijts, L. (Liesbeth), Ege, M. J. (Markus J.), Gauderman, W. J. (W. James), Georges, M. (Michel), Gieger, C. (Christian), Gilliland, F. (Frank), Granell, R. (Raquel), Gui, H. (Hongsheng), Hansen, T. (Torben), Heinrich, J. (Joachim), Henderson, J. (John), Hernandez-Pacheco, N. (Natalia), Holt, P. (Patrick), Imboden, M. (Medea), Jaddoe, V. W. (Vincent W. V.), Järvelin, M.-R. (Marjo-Riitta), Jarvis, D. L. (Deborah L.), Jensen, K. K. (Kamilla K.), Jonsdottir, I. (Ingileif), Kabesch, M. (Michael), Kaprio, J. (Jaakko), Kumar, A. (Ashish), Lee, Y.-A. (Young-Ae), Levin, A. M. (Albert M.), Li, X. (Xingnan), Lorenzo-Diaz, F. (Fabian), Melen, E. (Erik), Mercader, J. M. (Josep M.), Meyers, D. A. (Deborah A.), Myers, R. (Rachel), Nicolae, D. L. (Dan L.), Nohr, E. A. (Ellen A.), Palviainen, T. (Teemu), Paternoster, L. (Lavinia), Pennell, C. E. (Craig E.), Pershagen, G. (Goran), Pino-Yanes, M. (Maria), Probst-Hensch, N. M. (Nicole M.), Ruschendorf, F. (Franz), Simpson, A. (Angela), Stefansson, K. (Kari), Sunyer, J. (Jordi), Sveinbjornsson, G. (Gardar), Thiering, E. (Elisabeth), Thompson, P. J. (Philip J.), Torrent, M. (Maties), Torrents, D. (David), Tung, J. Y. (Joyce Y.), Wang, C. A. (Carol A.), Weidinger, S. (Stephan), Weiss, S. (Scott), Willemsen, G. (Gonneke), Williams, L. K. (L. Keoki), Ober, C. (Carole), Hinds, D. A. (David A.), Ferreira, M. A. (Manuel A.), Bisgaard, H. (Hans), Strachan, D. P. (David P.), and Bonnelykke, K. (Klaus)
Abstract: Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis. An Author Correction to this article was published on 16 August 2018. https://www.nature.com/articles/s41588-018-0197-6
Published: 2018

6. Genome-wide associations for birth weight and correlations with adult disease

Author: Horikoshi, M. (Momoko), Beaumont, R.N. (Robin N.), Day, F.R. (Felix), Warrington, N.M. (Nicole), Kooijman, M.N. (Marjolein), Fernandez-Tajes, J. (Juan), Feenstra, B. (Bjarke), Van Zuydam, N.R. (Natalie R.), Gaulton, K. (Kyle), Grarup, N. (Niels), Bradfield, J.P. (Jonathan), Strachan, D.P. (David), Li-Gao, R. (Ruifang), Ahluwalia, T.S. (Tarunveer Singh), Kreiner, E. (Eskil), Rueedi, R. (Rico), Lyytikäinen, L.-P. (Leo-Pekka), Cousminer, D.L. (Diana), Wu, Y. (Ying), Thiering, E. (Elisabeth), Wang, C.A. (Carol A.), Have, C.T. (Christian T.), Hottenga, J.J. (Jouke Jan), Vilor-Tejedor, N. (Natàlia), Joshi, P.K. (Peter), Boh, E.T.H. (Eileen Tai Hui), Ntalla, I. (Ioanna), Pitkanen, N. (Niina), Mahajan, A. (Anubha), Leeuwen, E.M. (Elisa) van, Joro, R. (Raimo), Lagou, V. (Vasiliki), Nodzenski, M. (Michael), Diver, L.A. (Louise A.), Zondervan, K.T. (Krina), Bustamante, M. (Mariona), Marques-Vidal, P. (Pedro), Mercader, J.M. (Josep), Bennett, A.J. (Amanda), Rahmioglu, N. (Nilufer), Nyholt, D.R. (Dale), Ma, R.C.W. (Ronald C. W.), Tam, C.H.T. (Claudia H. T.), Tam, W.H. (Wing Hung), Ganesh, S.K. (Santhi), Rooij, F.J.A. (Frank) van, Jones, S.E. (Samuel E.), Loh, P.-R. (Po-Ru), Ruth, K.S. (Katherine S.), Tuke, M.A. (Marcus A.), Tyrrell, A.W.R., Wood, A.R. (Andrew), Yaghootkar, H. (Hanieh), Scholtens, D.M. (Denise M.), Paternoster, L. (Lavinia), Prokopenko, I. (Inga), Kovacs, P. (Peter), Atalay, M. (Mustafa), Willems, S.M. (Sara), Panoutsopoulou, K. (Kalliope), Wang, X. (Xu), Carstensen, L. (Lisbeth), Geller, F. (Frank), Schraut, K.E. (Katharina E.), Murcia, M. (Mario), Beijsterveldt, C.E.M. (Toos) van, Willemsen, G.A.H.M. (Gonneke), Appel, E.V.R. (Emil V. R.), Fonvig, C.E. (Cilius E.), Trier, C. (Caecilie), Tiesler, C.M.T. (Carla M. T.), Standl, E. (Eberhard), Kutalik, Z. (Zoltán), Bonàs-Guarch, S. (Silvia), Hougaard, D.M. (David), Sánchez, F. (Friman), Torrents, D. (David), Waage, J. (Johannes), Hollegaard, M.V. (Mads V), Haan, H.G. (Hugoline) de, Rosendaal, F.R. (Frits), Medina-Gomez, C. (Carolina), Ring, S.M. (Susan), Hemani, G., Mcmahon, G. (George), Robertson, N.R. (Neil), Groves, C.J. (Christopher), Langenberg, C. (Claudia), Luan, J. (Jian'An), Scott, R.A. (Robert), Zhao, J.H. (Jing Hua), Mentch, F.D. (Frank), MacKenzie, S.M. (Scott M.), Reynolds, R.M. (Rebecca), Lowe Jr., W.L. (William), Tönjes, A. (Anke), Stumvoll, M. (Michael), Lindi, V. (Virpi), Lakka, T.A. (Timo), Duijn, C.M. (Cornelia) van, Kieß, W. (Wieland), KöRner, A. (Antje), Sørensen, T.I.A. (Thorkild), Niinikoski, H. (Harri), Pahkala, K. (Katja), Raitakari, O.T. (Olli T.), Zeggini, E. (Eleftheria), Dedoussis, G.V. (George), Teo, Y.Y. (Yik Ying), Saw, S.-M. (Seang-Mei), Melbye, M. (Mads), Campbell, H. (Harry), Wilson, J.F. (James F.), Vrijheid, M. (Martine), Geus, E.J.C. (Eco) de, Boomsma, D.I. (Dorret), Kadarmideen, H.N. (Haja N.), Holm, J.-C. (Jens-Christian), Hansen, T. (T.), Sebert, S. (Sylvain), Hattersley, A.T. (Andrew), Beilin, L.J. (Lawrence), Newnham, J.P. (John), Pennell, C.E. (Craig), Heinrich, J. (Joachim), Adair, L.S. (Linda), Borja, J.B. (Judith), Mohlke, K.L. (Karen), Hagen, K. (Knut), Widen, E. (Elisabeth), Kähönen, M. (Mika), Viikari, J. (Jorma), Lehtimäki, T. (Terho), Vollenweider, P. (Peter), Bønnelykke, K. (Klaus), Bisgaard, H. (Hans), Mook-Kanamori, D.O. (Dennis), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Pisinger, C. (Charlotta), Pedersen, O. (Oluf), Power, C. (Christopher), Hypponen, E. (Elina), Wareham, N.J. (Nick), Hakonarson, H. (Hakon), Davies, E. (Eleanor), Walker, B.R. (Brian R.), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), Grant, S.F.A. (Struan), Vaag, A.A. (Allan A.), Lawlor, D.A. (Debbie), Frayling, T.M. (Timothy), Smith, A.V. (Davey), Morris, A.P. (Andrew), Ong, K.K. (Ken), Felix, J.F. (Janine), Timpson, N.J. (Nicholas), Perry, J.R.B. (John), Evans, D.M. (David), McCarthy, M.I. (Mark), Freathy, R.M. (Rachel), Horikoshi, M. (Momoko), Beaumont, R.N. (Robin N.), Day, F.R. (Felix), Warrington, N.M. (Nicole), Kooijman, M.N. (Marjolein), Fernandez-Tajes, J. (Juan), Feenstra, B. (Bjarke), Van Zuydam, N.R. (Natalie R.), Gaulton, K. (Kyle), Grarup, N. (Niels), Bradfield, J.P. (Jonathan), Strachan, D.P. (David), Li-Gao, R. (Ruifang), Ahluwalia, T.S. (Tarunveer Singh), Kreiner, E. (Eskil), Rueedi, R. (Rico), Lyytikäinen, L.-P. (Leo-Pekka), Cousminer, D.L. (Diana), Wu, Y. (Ying), Thiering, E. (Elisabeth), Wang, C.A. (Carol A.), Have, C.T. (Christian T.), Hottenga, J.J. (Jouke Jan), Vilor-Tejedor, N. (Natàlia), Joshi, P.K. (Peter), Boh, E.T.H. (Eileen Tai Hui), Ntalla, I. (Ioanna), Pitkanen, N. (Niina), Mahajan, A. (Anubha), Leeuwen, E.M. (Elisa) van, Joro, R. (Raimo), Lagou, V. (Vasiliki), Nodzenski, M. (Michael), Diver, L.A. (Louise A.), Zondervan, K.T. (Krina), Bustamante, M. (Mariona), Marques-Vidal, P. (Pedro), Mercader, J.M. (Josep), Bennett, A.J. (Amanda), Rahmioglu, N. (Nilufer), Nyholt, D.R. (Dale), Ma, R.C.W. (Ronald C. W.), Tam, C.H.T. (Claudia H. T.), Tam, W.H. (Wing Hung), Ganesh, S.K. (Santhi), Rooij, F.J.A. (Frank) van, Jones, S.E. (Samuel E.), Loh, P.-R. (Po-Ru), Ruth, K.S. (Katherine S.), Tuke, M.A. (Marcus A.), Tyrrell, A.W.R., Wood, A.R. (Andrew), Yaghootkar, H. (Hanieh), Scholtens, D.M. (Denise M.), Paternoster, L. (Lavinia), Prokopenko, I. (Inga), Kovacs, P. (Peter), Atalay, M. (Mustafa), Willems, S.M. (Sara), Panoutsopoulou, K. (Kalliope), Wang, X. (Xu), Carstensen, L. (Lisbeth), Geller, F. (Frank), Schraut, K.E. (Katharina E.), Murcia, M. (Mario), Beijsterveldt, C.E.M. (Toos) van, Willemsen, G.A.H.M. (Gonneke), Appel, E.V.R. (Emil V. R.), Fonvig, C.E. (Cilius E.), Trier, C. (Caecilie), Tiesler, C.M.T. (Carla M. T.), Standl, E. (Eberhard), Kutalik, Z. (Zoltán), Bonàs-Guarch, S. (Silvia), Hougaard, D.M. (David), Sánchez, F. (Friman), Torrents, D. (David), Waage, J. (Johannes), Hollegaard, M.V. (Mads V), Haan, H.G. (Hugoline) de, Rosendaal, F.R. (Frits), Medina-Gomez, C. (Carolina), Ring, S.M. (Susan), Hemani, G., Mcmahon, G. (George), Robertson, N.R. (Neil), Groves, C.J. (Christopher), Langenberg, C. (Claudia), Luan, J. (Jian'An), Scott, R.A. (Robert), Zhao, J.H. (Jing Hua), Mentch, F.D. (Frank), MacKenzie, S.M. (Scott M.), Reynolds, R.M. (Rebecca), Lowe Jr., W.L. (William), Tönjes, A. (Anke), Stumvoll, M. (Michael), Lindi, V. (Virpi), Lakka, T.A. (Timo), Duijn, C.M. (Cornelia) van, Kieß, W. (Wieland), KöRner, A. (Antje), Sørensen, T.I.A. (Thorkild), Niinikoski, H. (Harri), Pahkala, K. (Katja), Raitakari, O.T. (Olli T.), Zeggini, E. (Eleftheria), Dedoussis, G.V. (George), Teo, Y.Y. (Yik Ying), Saw, S.-M. (Seang-Mei), Melbye, M. (Mads), Campbell, H. (Harry), Wilson, J.F. (James F.), Vrijheid, M. (Martine), Geus, E.J.C. (Eco) de, Boomsma, D.I. (Dorret), Kadarmideen, H.N. (Haja N.), Holm, J.-C. (Jens-Christian), Hansen, T. (T.), Sebert, S. (Sylvain), Hattersley, A.T. (Andrew), Beilin, L.J. (Lawrence), Newnham, J.P. (John), Pennell, C.E. (Craig), Heinrich, J. (Joachim), Adair, L.S. (Linda), Borja, J.B. (Judith), Mohlke, K.L. (Karen), Hagen, K. (Knut), Widen, E. (Elisabeth), Kähönen, M. (Mika), Viikari, J. (Jorma), Lehtimäki, T. (Terho), Vollenweider, P. (Peter), Bønnelykke, K. (Klaus), Bisgaard, H. (Hans), Mook-Kanamori, D.O. (Dennis), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Pisinger, C. (Charlotta), Pedersen, O. (Oluf), Power, C. (Christopher), Hypponen, E. (Elina), Wareham, N.J. (Nick), Hakonarson, H. (Hakon), Davies, E. (Eleanor), Walker, B.R. (Brian R.), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), Grant, S.F.A. (Struan), Vaag, A.A. (Allan A.), Lawlor, D.A. (Debbie), Frayling, T.M. (Timothy), Smith, A.V. (Davey), Morris, A.P. (Andrew), Ong, K.K. (Ken), Felix, J.F. (Janine), Timpson, N.J. (Nicholas), Perry, J.R.B. (John), Evans, D.M. (David), McCarthy, M.I. (Mark), and Freathy, R.M. (Rachel)
Abstract: Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease1. These lifecourse associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10-8). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (Rg =-0.22, P = 5.5 × 10-13), T2D (Rg =-0.27, P = 1.1 × 10-6) and coronary artery disease (Rg =-0.30, P = 6.5 × 10-9). In addition, using large-cohort datasets, we demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P = 1.9 × 10-4). We demonstrate that life-course associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and identify some of the pathways through which these causal genetic effects are mediated.
Published: 2016
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7. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M. (M.), Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., and Zidarn, M. (M.)
Abstract: The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social ine
Published: 2016
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8. A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Author: Middeldorp, C.M. (Christel), Hammerschlag, A.R. (Anke R.), Ouwens, K.G. (Klaasjan), Groen-Blokhuis, M. (Maria), St Pourcain, B. (Beate), Greven, C.U. (Corina U.), Pappa, M. (Magda), Tiesler, C.M.T. (Carla M.T.), Ang, W.Q. (Wei), Nolte, I.M. (Ilja), Vilor-Tejedor, N. (Natàlia), Bacelis, J. (Jonas), Ebejer, J.L. (Jane L.), Zhao, H. (Huiying), Davies, G.E. (Gareth), Ehli, E.A. (Erik), Evans, D.M. (David), Fedko, I.O. (Iryna O.), Guxens Junyent, M. (Mònica), Hottenga, J.J. (Jouke Jan), Hudziak, J.J. (James), Juqessur, A. (Astanand), Kemp, J.P. (John), Krapohl, E. (Eva), Martin, N.G. (Nicholas), Murcia, M. (Mario), Myhre, R. (Ronny), Ormel, J. (Johan), Ring, S.M. (Susan), Standl, E. (Eberhard), Stergiakouli, E. (Evangelia), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Timpson, N.J. (Nicholas), Trzaskowski, M. (Maciej), Most, P.J. (Peter) van der, Wang, C.A. (Carol A.), Nyholt, D.R. (Dale), Medland, S.E. (Sarah), Neale, B.M. (Benjamin), Jacobsson, B. (Bo), Sunyer, J. (Jordi), Hartman, C.A. (C.), Whitehouse, A.J.O. (Andrew), Pennell, C.E. (Craig), Heinrich, J. (Joachim), Plomin, R. (Robert), Smith, A.V. (Davey), Tiemeier, H.W. (Henning), Posthuma, D. (Danielle), Boomsma, D.I. (Dorret), Middeldorp, C.M. (Christel), Hammerschlag, A.R. (Anke R.), Ouwens, K.G. (Klaasjan), Groen-Blokhuis, M. (Maria), St Pourcain, B. (Beate), Greven, C.U. (Corina U.), Pappa, M. (Magda), Tiesler, C.M.T. (Carla M.T.), Ang, W.Q. (Wei), Nolte, I.M. (Ilja), Vilor-Tejedor, N. (Natàlia), Bacelis, J. (Jonas), Ebejer, J.L. (Jane L.), Zhao, H. (Huiying), Davies, G.E. (Gareth), Ehli, E.A. (Erik), Evans, D.M. (David), Fedko, I.O. (Iryna O.), Guxens Junyent, M. (Mònica), Hottenga, J.J. (Jouke Jan), Hudziak, J.J. (James), Juqessur, A. (Astanand), Kemp, J.P. (John), Krapohl, E. (Eva), Martin, N.G. (Nicholas), Murcia, M. (Mario), Myhre, R. (Ronny), Ormel, J. (Johan), Ring, S.M. (Susan), Standl, E. (Eberhard), Stergiakouli, E. (Evangelia), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Timpson, N.J. (Nicholas), Trzaskowski, M. (Maciej), Most, P.J. (Peter) van der, Wang, C.A. (Carol A.), Nyholt, D.R. (Dale), Medland, S.E. (Sarah), Neale, B.M. (Benjamin), Jacobsson, B. (Bo), Sunyer, J. (Jordi), Hartman, C.A. (C.), Whitehouse, A.J.O. (Andrew), Pennell, C.E. (Craig), Heinrich, J. (Joachim), Plomin, R. (Robert), Smith, A.V. (Davey), Tiemeier, H.W. (Henning), Posthuma, D. (Danielle), and Boomsma, D.I. (Dorret)
Abstract: Objective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests, and the overlap in results with a meta-analysis in the Psychiatric Genomics Consortium (PGC) case-control ADHD study was investigated. Results SNP-based heritability ranged from 5% to 34%, indicating that variation in common genetic variants influences ADHD symptom scores. The meta-analysis did not detect genome-wide significant SNPs, but three genes, lying close to each other with SNPs in high linkage disequilibrium (LD), showed a gene-wide significant association (p values between 1.46 × 10−6 and 2.66 × 10−6). One gene, WASL, is involved in neuronal development. Both SNP- and gene-based analyses indicated overlap with the PGC meta-analysis results with the genetic correlation estimated at 0.96. Conclusion The SNP-based heritability for ADHD symptom scores indicates a polygenic architecture, and genes involved in neurite outgrowth are possibly involved. Continuous and dichotomous measures of ADHD appear to assess a genetically common phenotype. A next step is to combine data from population-based and case-control cohorts in genetic association studies to increase sample size and to improve statistical power for identifying genetic variants.
Published: 2016
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9. Heritability and genome-wide association analyses of sleep duration in children: The EAGLE consortium

Author: Marinelli, A.W. (Andreas), Pappa, M. (Magda), Bustamante, M. (Mariona), Bonilla, C. (Carolina), Suarez, A. (Anna), Tiesler, C. (Carla), Vilor-Tejedor, N. (Natàlia), Zafarmand, M.H. (Mohammad Hadi), Alvarez-Pedrerol, M. (Mar), Andersson, S. (Sture), Bakermans-Kranenburg, M.J. (Marian), Estivill, X. (Xavier), Evans, D.M. (David), Flexeder, C. (Claudia), Forns, J. (Joan), Gonzalez, J.R. (Juan), Guxens Junyent, M. (Mònica), Huss, A. (Anke), IJzendoorn, M.H. (Rien) van, Jaddoe, V.W.V. (Vincent), Julvez, J. (Jordi), Lahti, J. (Jari), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Manz, J. (Judith), Mileva-Seitz, V. (Viara), Perola, M. (Markus), Pesonen, A.-K. (Anu-Katriina), Rivadeneira Ramirez, F. (Fernando), Salo, P. (Perttu), Shahand, S. (Shayan), Schulz, H. (Holger), Standl, E. (Eberhard), Thiering, E. (Eelisabeth), Timpson, N.J. (Nicholas), Torrent, M. (Maties), Uitterlinden, A.G. (André), Smith, A.V. (Davey), Estarlich, M. (Marisa), Heinrich, J. (Joachim), Räikkönen, K. (Katri), Vrijkotte, T.G.M. (Tanja), Tiemeier, H.W. (Henning), Sunyer, J. (Jordi), Marinelli, A.W. (Andreas), Pappa, M. (Magda), Bustamante, M. (Mariona), Bonilla, C. (Carolina), Suarez, A. (Anna), Tiesler, C. (Carla), Vilor-Tejedor, N. (Natàlia), Zafarmand, M.H. (Mohammad Hadi), Alvarez-Pedrerol, M. (Mar), Andersson, S. (Sture), Bakermans-Kranenburg, M.J. (Marian), Estivill, X. (Xavier), Evans, D.M. (David), Flexeder, C. (Claudia), Forns, J. (Joan), Gonzalez, J.R. (Juan), Guxens Junyent, M. (Mònica), Huss, A. (Anke), IJzendoorn, M.H. (Rien) van, Jaddoe, V.W.V. (Vincent), Julvez, J. (Jordi), Lahti, J. (Jari), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Manz, J. (Judith), Mileva-Seitz, V. (Viara), Perola, M. (Markus), Pesonen, A.-K. (Anu-Katriina), Rivadeneira Ramirez, F. (Fernando), Salo, P. (Perttu), Shahand, S. (Shayan), Schulz, H. (Holger), Standl, E. (Eberhard), Thiering, E. (Eelisabeth), Timpson, N.J. (Nicholas), Torrent, M. (Maties), Uitterlinden, A.G. (André), Smith, A.V. (Davey), Estarlich, M. (Marisa), Heinrich, J. (Joachim), Räikkönen, K. (Katri), Vrijkotte, T.G.M. (Tanja), Tiemeier, H.W. (Henning), and Sunyer, J. (Jordi)
Abstract: Study Objectives: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits. Methods: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase. Results: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h2 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism. Conclusions: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
Published: 2016
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10. Association of Forced Vital Capacity with the Developmental Gene NCOR2

Author: Minelli, C. (Cosetta), Dean, C.H. (Charlotte H.), Hind, M. (Matthew), Alves, A.C. (Alexessander Couto), Amaral, A.F.S. (André), Siroux, V. (V.), Huikari, V. (Ville), Artigas, M.S., Evans, D.M. (David M.), Loth, D.W. (Daan), Bossé, Y. (Yohan), Postma, D.S. (Dirkje), Sin, D.D., Thompson, J.R. (John), Demenais, F. (Florence), Henderson, J. (John), Bouzigon, E. (Emmanuelle), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Burney, P.G., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Albert), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David P.), James, A.L. (Alan L.), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nicholas J.), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna M.), Jong, K. (Kim) de, Thyagarajan, B. (Bharat), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari E.), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan F.), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), MVonk, J. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome I.), Gao, W. (Wei), White, W.B. (Wendy), Rich, S.S. (Stephen S.), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D.J. (David), Smith, L.J. (Lewis J.), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.B. (A Bill), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah L.), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), Connor, G.T. (George) O', Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan C.), MStarr, J. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher J.), MBurkart, K. (Kristin), Beilby, J. (John), Kritchevsky, S.B. (Stephen B.), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O. (O'Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Wjst, M. (Matthias), Kim, W.J. (Woo Jin), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne B.), Wilson, J.F. (James F), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), MVerhamme, F. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), London, S.J. (Stephanie J), Minelli, C. (Cosetta), Dean, C.H. (Charlotte H.), Hind, M. (Matthew), Alves, A.C. (Alexessander Couto), Amaral, A.F.S. (André), Siroux, V. (V.), Huikari, V. (Ville), Artigas, M.S., Evans, D.M. (David M.), Loth, D.W. (Daan), Bossé, Y. (Yohan), Postma, D.S. (Dirkje), Sin, D.D., Thompson, J.R. (John), Demenais, F. (Florence), Henderson, J. (John), Bouzigon, E. (Emmanuelle), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Burney, P.G., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Albert), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David P.), James, A.L. (Alan L.), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nicholas J.), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna M.), Jong, K. (Kim) de, Thyagarajan, B. (Bharat), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari E.), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan F.), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), MVonk, J. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome I.), Gao, W. (Wei), White, W.B. (Wendy), Rich, S.S. (Stephen S.), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D.J. (David), Smith, L.J. (Lewis J.), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.B. (A Bill), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah L.), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), Connor, G.T. (George) O', Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan C.), MStarr, J. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher J.), MBurkart, K. (Kristin), Beilby, J. (John), Kritchevsky, S.B. (Stephen B.), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O. (O'Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Wjst, M. (Matthias), Kim, W.J. (Woo Jin), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne B.), Wilson, J.F. (James F), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), MVerhamme, F. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), and London, S.J. (Stephanie J)
Abstract: Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 chil
Published: 2016
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11. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Author: Felix, J.F. (Janine), Bradfield, J.P. (Jonathan), Poppelaars-Monnereau, C. (Claire), Valk, R.J.P. (Ralf) van der, Stergiakouli, E. (Evie), Chesi, A. (Alessandra), Gaillard, R. (Romy), Feenstra, B. (Bjarke), Thiering, E. (Elisabeth), Kreiner-Møller, E. (Eskil), Mahajan, A. (Anubha), Pitkänen, N. (Niina), Joro, R. (Raimo), Cavadino, A. (Alana), Huikari, V. (Ville), Franks, S. (Steve), Groen-Blokhuis, M. (Maria), Cousminer, D.L. (Diana), Marsh, J.A. (Julie), Lehtimäki, T. (Terho), Curtin, J.A. (John), Vioque, J. (Jesus), Ahluwalia, T.S. (Tarunveer Singh), Myhre, R. (Ronny), Price, T.S. (Thomas), Vilor-Tejedor, N. (Natalia), Yengo, L. (Loic), Grarup, N. (Niels), Ntalla, I. (Ioanna), Ang, W.Q. (Wei), Atalay, M. (Mustafa), Bisgaard, H. (Hans), Blakemore, A.I.F. (Alexandra), Bonnefond, A. (Amélie), Carstensen, L. (Lisbeth), Eriksson, J.G. (Johan G.), Flexeder, C. (Claudia), Franke, L. (Lude), Geller, F. (Frank), Geserick, M. (Mandy), Hartikainen, A.L., Haworth, C.M.A. (Claire M.), Hirschhorn, J.N. (Joel N.), Hofman, A. (Albert), Holm, J.-C. (Jens-Christian), Horikoshi, M. (Momoko), Hottenga, J.J. (Jouke Jan), Huang, J. (Jian), Kadarmideen, H.N. (Haja N.), Kähönen, M. (Mika), Kiess, W. (Wieland), Lakka, T.A. (Timo), Lewin, A. (Alex), Liang, L. (Liming), Lyytikäinen, L.-P. (Leo-Pekka), Ma, B. (Baoshan), Magnus, P. (Per), McCormack, S.E. (Shana E.), Mcmahon, G. (George), Mentch, F.D. (Frank), Middeldorp, C.M. (Christel), Murray, C.S. (Clare S.), Pahkala, K. (Katja), Pers, T.H. (Tune), Pfäffle, R. (Roland), Postma, D.S. (Dirkje), Power, C. (Christine), Simpson, A. (Angela), Sengpiel, V. (Verena), Tiesler, C. (Carla), Torrent, M. (Maties), Uitterlinden, A.G. (André), Meurs, J.B.J. (Joyce) van, Vinding, R. (Rebecca), Waage, J. (Johannes), Wardle, J. (Jane), Zeggini, E. (Eleftheria), Zemel, B.S. (Babette S.), Dedoussis, G.V. (George), Pedersen, O. (Oluf), Froguel, P. (Philippe), Sunyer, J. (Jordi), Plomin, R. (Robert), Jacobsson, B. (Bo), Hansen, T. (Torben), Gonzalez, J.R. (Juan R.), Custovic, A. (Adnan), Raitakari, O.T. (Olli T.), Pennell, C.E. (Craig), Widén, E. (Elisabeth), Boomsma, D.I. (Dorret), Koppelman, G.H. (Gerard), Sebert, S. (Sylvain), Jarvelin, M.-R. (Marjo-Riitta), Hypponen, E. (Elina), McCarthy, M.I. (Mark), Lindi, V. (Virpi), Harri, N. (Niinikoski), Körner, A. (Antje), Bønnelykke, K. (Klaus), Heinrich, J. (Joachim), Melbye, M. (Mads), Rivadeneira Ramirez, F. (Fernando), Hakonarson, H. (Hakon), Ring, S.M. (Susan), Smith, A.V. (Davey), Sørensen, T.I.A. (Thorkild I.A.), Timpson, N.J. (Nicholas), Grant, S.F.A. (Struan), Jaddoe, V.W.V. (Vincent), Kalkwarf, H.J. (Heidi J.), Lappe, J.M. (Joan M.), Gilsanz, V. (Vicente), Oberfield, S.E. (Sharon E.), Shepherd, J.A. (John A.), Kelly, A. (Andrea), Felix, J.F. (Janine), Bradfield, J.P. (Jonathan), Poppelaars-Monnereau, C. (Claire), Valk, R.J.P. (Ralf) van der, Stergiakouli, E. (Evie), Chesi, A. (Alessandra), Gaillard, R. (Romy), Feenstra, B. (Bjarke), Thiering, E. (Elisabeth), Kreiner-Møller, E. (Eskil), Mahajan, A. (Anubha), Pitkänen, N. (Niina), Joro, R. (Raimo), Cavadino, A. (Alana), Huikari, V. (Ville), Franks, S. (Steve), Groen-Blokhuis, M. (Maria), Cousminer, D.L. (Diana), Marsh, J.A. (Julie), Lehtimäki, T. (Terho), Curtin, J.A. (John), Vioque, J. (Jesus), Ahluwalia, T.S. (Tarunveer Singh), Myhre, R. (Ronny), Price, T.S. (Thomas), Vilor-Tejedor, N. (Natalia), Yengo, L. (Loic), Grarup, N. (Niels), Ntalla, I. (Ioanna), Ang, W.Q. (Wei), Atalay, M. (Mustafa), Bisgaard, H. (Hans), Blakemore, A.I.F. (Alexandra), Bonnefond, A. (Amélie), Carstensen, L. (Lisbeth), Eriksson, J.G. (Johan G.), Flexeder, C. (Claudia), Franke, L. (Lude), Geller, F. (Frank), Geserick, M. (Mandy), Hartikainen, A.L., Haworth, C.M.A. (Claire M.), Hirschhorn, J.N. (Joel N.), Hofman, A. (Albert), Holm, J.-C. (Jens-Christian), Horikoshi, M. (Momoko), Hottenga, J.J. (Jouke Jan), Huang, J. (Jian), Kadarmideen, H.N. (Haja N.), Kähönen, M. (Mika), Kiess, W. (Wieland), Lakka, T.A. (Timo), Lewin, A. (Alex), Liang, L. (Liming), Lyytikäinen, L.-P. (Leo-Pekka), Ma, B. (Baoshan), Magnus, P. (Per), McCormack, S.E. (Shana E.), Mcmahon, G. (George), Mentch, F.D. (Frank), Middeldorp, C.M. (Christel), Murray, C.S. (Clare S.), Pahkala, K. (Katja), Pers, T.H. (Tune), Pfäffle, R. (Roland), Postma, D.S. (Dirkje), Power, C. (Christine), Simpson, A. (Angela), Sengpiel, V. (Verena), Tiesler, C. (Carla), Torrent, M. (Maties), Uitterlinden, A.G. (André), Meurs, J.B.J. (Joyce) van, Vinding, R. (Rebecca), Waage, J. (Johannes), Wardle, J. (Jane), Zeggini, E. (Eleftheria), Zemel, B.S. (Babette S.), Dedoussis, G.V. (George), Pedersen, O. (Oluf), Froguel, P. (Philippe), Sunyer, J. (Jordi), Plomin, R. (Robert), Jacobsson, B. (Bo), Hansen, T. (Torben), Gonzalez, J.R. (Juan R.), Custovic, A. (Adnan), Raitakari, O.T. (Olli T.), Pennell, C.E. (Craig), Widén, E. (Elisabeth), Boomsma, D.I. (Dorret), Koppelman, G.H. (Gerard), Sebert, S. (Sylvain), Jarvelin, M.-R. (Marjo-Riitta), Hypponen, E. (Elina), McCarthy, M.I. (Mark), Lindi, V. (Virpi), Harri, N. (Niinikoski), Körner, A. (Antje), Bønnelykke, K. (Klaus), Heinrich, J. (Joachim), Melbye, M. (Mads), Rivadeneira Ramirez, F. (Fernando), Hakonarson, H. (Hakon), Ring, S.M. (Susan), Smith, A.V. (Davey), Sørensen, T.I.A. (Thorkild I.A.), Timpson, N.J. (Nicholas), Grant, S.F.A. (Struan), Jaddoe, V.W.V. (Vincent), Kalkwarf, H.J. (Heidi J.), Lappe, J.M. (Joan M.), Gilsanz, V. (Vicente), Oberfield, S.E. (Sharon E.), Shepherd, J.A. (John A.), and Kelly, A. (Andrea)
Abstract: A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown.We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores.We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10-8) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10-10) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in streng
Published: 2016
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12. Dietary Intake, FTO genetic variants, and adiposity: A combined analysis of over 16,000 children and adolescents

Author: Qi, Q. (Qibin), Downer, M.K. (Mary K.), Kilpeläinen, T.O. (Tuomas), Taal, H.R. (Rob), Barton, S.J. (Sheila), Ntalla, I. (Ioanna), Standl, E. (Eberhard), Boraska, V. (Vesna), Huikari, V. (Ville), Kiefte-de Jong, J.C. (Jessica), KöRner, A. (Antje), Lakka, T.A. (Timo), Liu, G. (Gaifen), Magnusson, J. (Jessica), Okuda, M. (Masayuki), Raitakari, O. (Olli), Richmond, R.C. (Rebecca C.), Scott, R.A. (Robert), Bailey, M.E.S. (Mark), Scheuermann, K. (Kathrin), Holloway, J. (John), Inskip, H.M. (Hazel), Isasi, C.R. (Carmen R.), Mossavar-Rahmani, Y. (Yasmin), Jaddoe, V.W.V. (Vincent), Laitinen, J. (Jaana), Lindi, V. (Virpi), Melén, E. (Erik), Pitsiladis, Y. (Yannis), Pitkanen, N. (Niina), Snieder, H. (Harold), Heinrich, J. (Joachim), Timpson, N.J. (Nicholas), Wang, T. (Teng), Yuji, H. (Hinoda), Zeggini, E. (Eleftheria), Dedoussis, G.V. (George), Kaplan, R.C. (Robert), Wylie-Rosett, J. (Judith), Loos, R.J.F. (Ruth), Hu, F.B. (Frank), Qi, L. (Lu), Qi, Q. (Qibin), Downer, M.K. (Mary K.), Kilpeläinen, T.O. (Tuomas), Taal, H.R. (Rob), Barton, S.J. (Sheila), Ntalla, I. (Ioanna), Standl, E. (Eberhard), Boraska, V. (Vesna), Huikari, V. (Ville), Kiefte-de Jong, J.C. (Jessica), KöRner, A. (Antje), Lakka, T.A. (Timo), Liu, G. (Gaifen), Magnusson, J. (Jessica), Okuda, M. (Masayuki), Raitakari, O. (Olli), Richmond, R.C. (Rebecca C.), Scott, R.A. (Robert), Bailey, M.E.S. (Mark), Scheuermann, K. (Kathrin), Holloway, J. (John), Inskip, H.M. (Hazel), Isasi, C.R. (Carmen R.), Mossavar-Rahmani, Y. (Yasmin), Jaddoe, V.W.V. (Vincent), Laitinen, J. (Jaana), Lindi, V. (Virpi), Melén, E. (Erik), Pitsiladis, Y. (Yannis), Pitkanen, N. (Niina), Snieder, H. (Harold), Heinrich, J. (Joachim), Timpson, N.J. (Nicholas), Wang, T. (Teng), Yuji, H. (Hinoda), Zeggini, E. (Eleftheria), Dedoussis, G.V. (George), Kaplan, R.C. (Robert), Wylie-Rosett, J. (Judith), Loos, R.J.F. (Ruth), Hu, F.B. (Frank), and Qi, L. (Lu)
Abstract: The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macr
Published: 2015
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13. Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

Author: Fuertes, E. (Elaine), Söderhäll, C. (Cilla), Acevedo, N. (Nathalie), Becker, A. (Albert), Brauer, M., Chan Yeung, M. (Moira), Dijk, F.N. (Nicole), Heinrich, J. (Joachim), Jongste, J.C. (Johan) de, Koppelman, G.H. (Gerard), Postma, D.S. (Dirkje), Kere, J. (Juha), Kozyrskyj, A. (Anita), Pershagen, G. (Göran), Sandford, A. (Andrew), Standl, E. (Eberhard), Tiesler, C. (Carla), Waldenberger, M. (Melanie), Westman, M. (Marit), Carlsten, C. (Christopher), Melén, E. (Erik), Fuertes, E. (Elaine), Söderhäll, C. (Cilla), Acevedo, N. (Nathalie), Becker, A. (Albert), Brauer, M., Chan Yeung, M. (Moira), Dijk, F.N. (Nicole), Heinrich, J. (Joachim), Jongste, J.C. (Johan) de, Koppelman, G.H. (Gerard), Postma, D.S. (Dirkje), Kere, J. (Juha), Kozyrskyj, A. (Anita), Pershagen, G. (Göran), Sandford, A. (Andrew), Standl, E. (Eberhard), Tiesler, C. (Carla), Waldenberger, M. (Melanie), Westman, M. (Marit), Carlsten, C. (Christopher), and Melén, E. (Erik)
Published: 2015
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14. Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

Author: Fuertes, E, Soderhall, C, Acevedo, N, Becker, A, Brauer, M, Chan-Yeung, M, Dijk, FN, Heinrich, J (Joachim), Jongste, Johan, Koppelman, GH, Postma, DS, Kere, J, Kozyrskyj, AL, Pershagen, G, Sandford, A, Standl, M, Tiesler, CMT, Waldenberger, M, Westman, M, Carlsten, C, Melen, E, Fuertes, E, Soderhall, C, Acevedo, N, Becker, A, Brauer, M, Chan-Yeung, M, Dijk, FN, Heinrich, J (Joachim), Jongste, Johan, Koppelman, GH, Postma, DS, Kere, J, Kozyrskyj, AL, Pershagen, G, Sandford, A, Standl, M, Tiesler, CMT, Waldenberger, M, Westman, M, Carlsten, C, and Melen, E
Published: 2015

15. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author: Loth, D.W. (Daan), Artigas, M.S., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Davey), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David), James, A.L. (Alan), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nick), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna), Thyagarajan, B. (Bharat), Alves, A.C. (Alexessander Couto), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), Vonk, J.M. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S.H. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome), Gao, W. (Wei), Postma, D.S. (Dirkje), White, W.B. (Wendy), Rich, S.S. (Stephen), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D. (David), Smith, L.J. (Lewis), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.W. (Arthur), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), O'Connor, G.T. (George), Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan), Starr, J.M. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher), Burkart, K.M. (Kristin), Beilby, J.P. (John), Kritchevsky, S.B. (Stephen), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O.D. (Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Jong, K.T. (Kim) de, Wjst, M. (Matthias), Kim, W.H. (Woo), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne), Jarvelin, M.-R. (Marjo-Riitta), Wilson, J.F. (James), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), Verhamme, F.M. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), London, S.J. (Stephanie), Loth, D.W. (Daan), Artigas, M.S., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Davey), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David), James, A.L. (Alan), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nick), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna), Thyagarajan, B. (Bharat), Alves, A.C. (Alexessander Couto), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), Vonk, J.M. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S.H. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome), Gao, W. (Wei), Postma, D.S. (Dirkje), White, W.B. (Wendy), Rich, S.S. (Stephen), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D. (David), Smith, L.J. (Lewis), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.W. (Arthur), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), O'Connor, G.T. (George), Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan), Starr, J.M. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher), Burkart, K.M. (Kristin), Beilby, J.P. (John), Kritchevsky, S.B. (Stephen), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O.D. (Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Jong, K.T. (Kim) de, Wjst, M. (Matthias), Kim, W.H. (Woo), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne), Jarvelin, M.-R. (Marjo-Riitta), Wilson, J.F. (James), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), Verhamme, F.M. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), and London, S.J. (Stephanie)
Abstract: Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
Published: 2014
Full Text: View/download PDF

16. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author: Loth, D.W. (Daan), Artigas, M.S., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Davey), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David), James, A.L. (Alan), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nick), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna), Thyagarajan, B. (Bharat), Alves, A.C. (Alexessander Couto), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), Vonk, J.M. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S.H. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome), Gao, W. (Wei), Postma, D.S. (Dirkje), White, W.B. (Wendy), Rich, S.S. (Stephen), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D. (David), Smith, L.J. (Lewis), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.W. (Arthur), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), O'Connor, G.T. (George), Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan), Starr, J.M. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher), Burkart, K.M. (Kristin), Beilby, J.P. (John), Kritchevsky, S.B. (Stephen), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O.D. (Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Jong, K.T. (Kim) de, Wjst, M. (Matthias), Kim, W.H. (Woo), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne), Jarvelin, M.-R. (Marjo-Riitta), Wilson, J.F. (James), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), Verhamme, F.M. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), London, S.J. (Stephanie), Loth, D.W. (Daan), Artigas, M.S., Gharib, S.A. (Sina), Wain, L.V. (Louise), Franceschini, N. (Nora), Koch, B. (Beate), Pottinger, T.D. (Tess), Smith, A.V. (Davey), Duan, Q. (Qing), Oldmeadow, C. (Christopher), Lee, M.K. (Mi Kyeong), Strachan, D.P. (David), James, A.L. (Alan), Huffman, J.E. (Jennifer), Vitart, V. (Veronique), Ramasamy, A. (Adaikalavan), Wareham, N.J. (Nick), Kaprio, J. (Jaakko), Wang, X.-Q. (Xin-Qun), Trochet, H. (Holly), Kähönen, M. (Mika), Flexeder, C. (Claudia), Albrecht, E. (Eva), Lopez, L.M. (Lorna), Thyagarajan, B. (Bharat), Alves, A.C. (Alexessander Couto), Enroth, S. (Stefan), Omenaas, E. (Ernst), Joshi, P.K. (Peter), Fall, M. (Magnus), Viñuela, A. (Ana), Launer, L.J. (Lenore), Loehr, L.R. (Laura), Fornage, M. (Myriam), Li, G. (Guo), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Manichaikul, A. (Ani), Lahousse, L. (Lies), Harris, T.B. (Tamara), North, K.E. (Kari), Rudnicka, A.R. (Alicja), Hui, J. (Jennie), Gu, X. (Xiangjun), Lumley, T. (Thomas), Wright, A.F. (Alan), Hastie, N. (Nick), Campbell, S. (Susan), Kumar, R. (Rajesh), Pin, I. (Isabelle), Scott, R.A. (Robert), Pietilainen, K.H. (Kirsi Hannele), Surakka, I. (Ida), Liu, Y. (YongMei), Holliday, E.G. (Elizabeth), Schulz, H. (Holger), Heinrich, J. (Joachim), Davies, G. (Gail), Vonk, J.M. (Judith), Wojczynski, M.K. (Mary ), Pouta, A. (Anneli), Johansson, A. (Åsa), Wild, S.H. (Sarah), Ingelsson, E. (Erik), Rivadeneira Ramirez, F. (Fernando), Völzke, H. (Henry), Hysi, P.G. (Pirro), Eiriksdottir, G. (Gudny), Morrison, A.C. (Alanna), Rotter, J.I. (Jerome), Gao, W. (Wei), Postma, D.S. (Dirkje), White, W.B. (Wendy), Rich, S.S. (Stephen), Hofman, A. (Albert), Aspelund, T. (Thor), Couper, D. (David), Smith, L.J. (Lewis), Psaty, B.M. (Bruce), Lohman, K. (Kurt), Burchard, E.G. (Esteban), Uitterlinden, A.G. (André), Garcia, M. (Melissa), Joubert, B.R. (Bonnie), McArdle, W.L. (Wendy), Musk, A.W. (Arthur), Hansel, C.R.W. (Christian), Heckbert, S.R. (Susan), Zgaga, L. (Lina), Meurs, J.B.J. (Joyce) van, Navarro, P. (Pau), Rudan, I. (Igor), Oh, Y.-M. (Yeon-Mok), Redline, S. (Susan), Jarvis, D.L. (Deborah), Zhao, J.H. (Jing Hua), Rantanen, T. (Taina), O'Connor, G.T. (George), Ripatti, S. (Samuli), Scott, R.J. (Rodney), Karrasch, S. (Stefan), Grallert, H. (Harald), Gaddis, N.C. (Nathan), Starr, J.M. (John), Wijmenga, C. (Cisca), Minster, R.L. (Ryan), Lederer, C.W. (Carsten), Pekkanen, J. (Juha), Gyllensten, U. (Ulf), Campbell, H. (Harry), Morris, A.P. (Andrew), Gläser, S. (Sven), Hammond, C.J. (Christopher), Burkart, K.M. (Kristin), Beilby, J.P. (John), Kritchevsky, S.B. (Stephen), Gudnason, V. (Vilmundur), Hancock, D.B. (Dana), Williams, O.D. (Dale), Polasek, O. (Ozren), Zemunik, T. (Tatijana), Kolcic, I. (Ivana), Petrini, M.F. (Marcy), Jong, K.T. (Kim) de, Wjst, M. (Matthias), Kim, W.H. (Woo), Porteous, D.J. (David J.), Scotland, G. (Generation), Smith, B.H. (Blair), Viljanen, A. (Anne), Heliovaara, M. (Markku), Attia, J. (John), Sayers, I. (Ian), Hampel, R. (Regina), Gieger, C. (Christian), Deary, I.J. (Ian), Boezen, H.M. (Marike), Newman, A.B. (Anne), Jarvelin, M.-R. (Marjo-Riitta), Wilson, J.F. (James), Lind, L. (Lars), Stricker, B.H.Ch. (Bruno), Teumer, A. (Alexander), Spector, T.D. (Timothy), Melén, E. (Erik), Peters, M.J. (Marjolein), Lange, L.A. (Leslie), Barr, R.G. (Graham), Bracke, K.R. (Ken), Verhamme, F.M. (Fien), Sung, J. (Joohon), Hiemstra, P.S. (Pieter), Cassano, P.A. (Patricia), Sood, A. (Akshay), Hayward, C. (Caroline), Dupuis, J. (Josée), Hall, I.P. (Ian), Brusselle, G.G. (Guy), Tobin, M.D. (Martin), and London, S.J. (Stephanie)
Abstract: Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
Published: 2014
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17. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

Author: Tang, W. (Wenbo), Kowgier, M. (Matthew), Loth, D.W. (Daan), Soler Artigas, M. (Maria), Joubert, B.R. (Bonnie), Hodge, E. (Emily), Gharib, S.A. (Sina), Smith, A.V. (Davey), Ruczinski, I. (Ingo), Gudnason, V. (Vilmundur), Mathias, J. (Jasmine), Harris, T.B. (Tamara), Hansel, C.R.W. (Christian), Launer, L.J. (Lenore), Barnes, K.C. (Kathleen), Hansen, J.G. (Joyanna), Albrecht, E. (Eva), Aldrich, M.C. (Melinda), Allerhand, M.M. (Michael), Barr, R.G. (Graham), Brusselle, G.G. (Guy), Couper, D.J. (David), Curjuric, I. (Ivan), Davies, G. (Gail), Deary, I.J. (Ian), Dupuis, J. (Josée), Fall, M. (Magnus), Foy, M. (Millennia), Franceschini, N. (Nora), Gao, W. (Wei), Gläser, S. (Sven), Gu, X. (Xiangjun), Hancock, D.B. (Dana), Heinrich, J. (Joachim), Hofman, A. (Albert), Imboden, M. (Medea), Ingelsson, E. (Erik), James, A. (Alan), Karrasch, S. (Stefan), Koch, B. (Beate), Kritchevsky, S.B. (Stephen), Kumar, A. (Ashish), Lahousse, L. (Lies), Li, G. (Guo), Lind, L. (Lars), Lindgren, C.M. (Cecilia), Liu, Y. (YongMei), Lohman, K. (Kurt), Lumley, T. (Thomas), McArdle, W.L. (Wendy), Meibohm, B. (Bernd), Morris, A.P. (Andrew), Morrison, A.C. (Alanna), Musk, A.W. (Arthur), North, K.E. (Kari), Palmer, C. (Cameron), Probst-Hensch, N.M. (Nicole M.), Psaty, B.M. (Bruce), Rivadeneira Ramirez, F. (Fernando), Rotter, J.I. (Jerome), Schulz, H. (Holger), Smith, L.J. (Lewis), Sood, A. (Akshay), Starr, J.M. (John), Strachan, D.P. (David), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Völzke, H. (Henry), Voorman, J.M. (Jeanine), Wain, L.V. (Louise), Wells, M.T. (Martin), Wilk, J.B. (Jemma), Williams, O.D. (Dale), Heckbert, S.R. (Susan), Stricker, B.H.Ch. (Bruno), London, S.J. (Stephanie), Fornage, M. (Myriam), Tobin, M.D. (Martin), O'Connor, G.T. (George), Hall, I.P. (Ian), Cassano, P.A. (Patricia), Tang, W. (Wenbo), Kowgier, M. (Matthew), Loth, D.W. (Daan), Soler Artigas, M. (Maria), Joubert, B.R. (Bonnie), Hodge, E. (Emily), Gharib, S.A. (Sina), Smith, A.V. (Davey), Ruczinski, I. (Ingo), Gudnason, V. (Vilmundur), Mathias, J. (Jasmine), Harris, T.B. (Tamara), Hansel, C.R.W. (Christian), Launer, L.J. (Lenore), Barnes, K.C. (Kathleen), Hansen, J.G. (Joyanna), Albrecht, E. (Eva), Aldrich, M.C. (Melinda), Allerhand, M.M. (Michael), Barr, R.G. (Graham), Brusselle, G.G. (Guy), Couper, D.J. (David), Curjuric, I. (Ivan), Davies, G. (Gail), Deary, I.J. (Ian), Dupuis, J. (Josée), Fall, M. (Magnus), Foy, M. (Millennia), Franceschini, N. (Nora), Gao, W. (Wei), Gläser, S. (Sven), Gu, X. (Xiangjun), Hancock, D.B. (Dana), Heinrich, J. (Joachim), Hofman, A. (Albert), Imboden, M. (Medea), Ingelsson, E. (Erik), James, A. (Alan), Karrasch, S. (Stefan), Koch, B. (Beate), Kritchevsky, S.B. (Stephen), Kumar, A. (Ashish), Lahousse, L. (Lies), Li, G. (Guo), Lind, L. (Lars), Lindgren, C.M. (Cecilia), Liu, Y. (YongMei), Lohman, K. (Kurt), Lumley, T. (Thomas), McArdle, W.L. (Wendy), Meibohm, B. (Bernd), Morris, A.P. (Andrew), Morrison, A.C. (Alanna), Musk, A.W. (Arthur), North, K.E. (Kari), Palmer, C. (Cameron), Probst-Hensch, N.M. (Nicole M.), Psaty, B.M. (Bruce), Rivadeneira Ramirez, F. (Fernando), Rotter, J.I. (Jerome), Schulz, H. (Holger), Smith, L.J. (Lewis), Sood, A. (Akshay), Starr, J.M. (John), Strachan, D.P. (David), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Völzke, H. (Henry), Voorman, J.M. (Jeanine), Wain, L.V. (Louise), Wells, M.T. (Martin), Wilk, J.B. (Jemma), Williams, O.D. (Dale), Heckbert, S.R. (Susan), Stricker, B.H.Ch. (Bruno), London, S.J. (Stephanie), Fornage, M. (Myriam), Tobin, M.D. (Martin), O'Connor, G.T. (George), Hall, I.P. (Ian), and Cassano, P.A. (Patricia)
Published: 2014
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18. Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

Author: Tang, WB, Kowgier, M, Loth, Daan, Artigas, MS, Joubert, BR, Hodge, E, Gharib, SA, Smith, AV, Ruczinski, I, Gudnason, V, Mathias, RA, Harris, TB, Hansel, NN, Launer, LJ (Lenore), Barnes, KC, Hansen, JG, Albrecht, E, Aldrich, MC, Allerhand, M, Barr, RG, Brusselle, Guy, Couper, DJ, Curjuric, I, Davies, G, Deary, IJ, Dupuis, J, Fall, T, Foy, M, Franceschini, N, Gao, W, Glaser, S, Gu, XJ, Hancock, DB, Heinrich, J (Joachim), Hofman, Bert, Imboden, M, Ingelsson, E, James, A, Karrasch, S, Koch, B, Kritchevsky, SB, Kumar, A, Lahousse, Lies, Li, G, Lind, L, Lindgren, C, Liu, YM, Lohman, K, Lumley, T, McArdle, WL, Meibohm, B, Morris, AP, Morrison, AC, Musk, B, North, KE, Palmer, LJ, Probst-Hensch, NM, Psaty, BM, Rivadeneira, Fernando, Rotter, JI, Schulz, H, Smith, LJ, Sood, A, Starr, JM, Strachan, DP, Teumer, A, Uitterlinden, André, Volzke, H, Voorman, A, Wain, LV, Wells, MT, Wilk, JB, Williams, OD, Heckbert, SR, Stricker, Bruno, London, SJ, Fornage, M, Tobin, MD, O'Connor, GT, Hall, IP, Cassano, PA, Tang, WB, Kowgier, M, Loth, Daan, Artigas, MS, Joubert, BR, Hodge, E, Gharib, SA, Smith, AV, Ruczinski, I, Gudnason, V, Mathias, RA, Harris, TB, Hansel, NN, Launer, LJ (Lenore), Barnes, KC, Hansen, JG, Albrecht, E, Aldrich, MC, Allerhand, M, Barr, RG, Brusselle, Guy, Couper, DJ, Curjuric, I, Davies, G, Deary, IJ, Dupuis, J, Fall, T, Foy, M, Franceschini, N, Gao, W, Glaser, S, Gu, XJ, Hancock, DB, Heinrich, J (Joachim), Hofman, Bert, Imboden, M, Ingelsson, E, James, A, Karrasch, S, Koch, B, Kritchevsky, SB, Kumar, A, Lahousse, Lies, Li, G, Lind, L, Lindgren, C, Liu, YM, Lohman, K, Lumley, T, McArdle, WL, Meibohm, B, Morris, AP, Morrison, AC, Musk, B, North, KE, Palmer, LJ, Probst-Hensch, NM, Psaty, BM, Rivadeneira, Fernando, Rotter, JI, Schulz, H, Smith, LJ, Sood, A, Starr, JM, Strachan, DP, Teumer, A, Uitterlinden, André, Volzke, H, Voorman, A, Wain, LV, Wells, MT, Wilk, JB, Williams, OD, Heckbert, SR, Stricker, Bruno, London, SJ, Fornage, M, Tobin, MD, O'Connor, GT, Hall, IP, and Cassano, PA
Abstract: Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. Results: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 x 10(-7)). In addition, meta-analysis using the five cohorts with >= 3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 x 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. Conclusions: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.
Published: 2014

19. Telomere length in circulating leukocytes is associated with lung function and disease

Author: Albrecht, E, Sillanpaa, E, Karrasch, S, Alves, AC, Codd, V, Hovatta, I, Buxton, JL, Nelson, CP, Broer, Linda, Hagg, S, Mangino, M, Willemsen, G, Surakka, I, Ferreira, MAR, Amin, Najaf, Oostra, Ben, Backmand, HM, Peltonen, M, Sarna, S, Rantanen, T, Sipila, S, Korhonen, T, Madden, PAF, Gieger, C, Jorres, RA, Heinrich, J (Joachim), Behr, J, Huber, RM, Peters, A, Strauch, K, Wichmann, HE, Waldenberger, M, Blakemore, AIF, de Geus, EJC, Nyholt, DR, Henders, AK, Piirila, PL, Rissanen, A, Magnusson, PKE, Vinuela, A, Pietilainen, KH, Martin, NG, Pedersen, NL, Boomsma, DI, Spector, TD, Duijn, Cornelia, Kaprio, J, Samani, NJ, Jarvelin, MR, Schulz, H, Albrecht, E, Sillanpaa, E, Karrasch, S, Alves, AC, Codd, V, Hovatta, I, Buxton, JL, Nelson, CP, Broer, Linda, Hagg, S, Mangino, M, Willemsen, G, Surakka, I, Ferreira, MAR, Amin, Najaf, Oostra, Ben, Backmand, HM, Peltonen, M, Sarna, S, Rantanen, T, Sipila, S, Korhonen, T, Madden, PAF, Gieger, C, Jorres, RA, Heinrich, J (Joachim), Behr, J, Huber, RM, Peters, A, Strauch, K, Wichmann, HE, Waldenberger, M, Blakemore, AIF, de Geus, EJC, Nyholt, DR, Henders, AK, Piirila, PL, Rissanen, A, Magnusson, PKE, Vinuela, A, Pietilainen, KH, Martin, NG, Pedersen, NL, Boomsma, DI, Spector, TD, Duijn, Cornelia, Kaprio, J, Samani, NJ, Jarvelin, MR, and Schulz, H
Abstract: Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in is (FEV1), forced vital capacity (PVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (beta= -0.0452, p= 0.024) as well as COPD (beta= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07 x 10(-7)), FVC (p=2.07 x 10(-5)), and FEV1/FVC (p =5.27 x 10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
Published: 2014

20. A common biological basis of obesity and nicotine addiction

Author: Thorgeirsson, T.E. (Thorgeir), Gudbjartsson, D.F. (Daniel), Sulem, P. (Patrick), Besenbacher, S. (Søren), Styrkarsdottir, U. (Unnur), Thorleifsson, G. (Gudmar), Walters, G.B. (Bragi), Furberg, H. (Helena), Sullivan, P. (Patrick), Marchini, J. (Jonathan), McCarthy, M.I. (M.), Steinthorsdottir, V. (Valgerdur), Thorsteinsdottir, U. (Unnur), Zwart, J-A. (John-Anker), Surakka, I. (Ida), Vink, J.M. (Jacqueline), Amin, N. (Najaf), Geller, F. (Frank), Rafnar, T. (Thorunn), Esko, T. (Tõnu), Walter, S. (Stefan), Gieger, C. (Christian), Rawal, R. (Rajesh), Mangino, M. (Massimo), Prokopenko, I. (Inga), Mägi, R. (Reedik), Keskitalo, K. (Kaisu), Gudjonsdottir, I.H. (Iris), Gretarsdottir, S. (Solveig), Stefansson, H. (Hreinn), Aulchenko, Y.S. (Yurii), Nelis, M. (Mari), Aben, K.K.H. (Katja), Heijer, M. (Martin) den, Soranzo, N. (Nicole), Valdes, A.M. (Ana Maria), Steves, C.J. (Claire), Uitterlinden, A.G. (André), Hofman, A. (Albert), Tönjes, A. (Anke), Kovacs, P. (Peter), Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Vogelzangs, N. (Nicole), Döring, A. (Angela), Dahmen, N. (N.), Nitz, B. (Barbara), Ripatti, S. (Samuli), Perola, M. (Markus), Kettunen, J. (Johannes), Hartikainen, A.L., Pouta, A. (Anneli), Laitinen, J. (Jaana), Isohanni, M.K. (Matti), Huei-Yi, S. (Shen), Allen, M. (Maxine), Krestyaninova, M. (Maria), Hall, A. (Anne), Thompson, J.R. (John), Oskarsson, H. (Hogni), Tyrfingsson, T. (Thorarinn), Kiemeney, L.A.L.M. (Bart), Jarvelin, M.-R. (Marjo-Riitta), Salomaa, V. (Veikko), Stumvoll, M. (Michael), Spector, T.D. (Timothy), Wichmann, H.E. (Heinz Erich), Metspalu, A. (Andres), Samani, N.J. (Nilesh), Penninx, B.W.J.H. (Brenda), Oostra, B.A. (Ben), Boomsma, D.I. (Dorret), Tiemeier, H.W. (Henning), Duijn, C.M. (Cornelia) van, Kaprio, J. (Jaakko), Gulcher, J.R. (Jeffrey), Kim, Y. (Yunjung), Dackor, J. (Jennifer), Boerwinkle, E.A. (Eric), Franceschini, N. (Nora), Ardissino, D. (Diego), Bernardinelli, L. (Luisa), Mannucci, P.M. (Pier), Mauri, F. (Francesco), Merlini, P.A. (Piera), Absher, D. (Devin), Assimes, T.L. (Themistocles), Fortmann, S.P. (Stephen), Iribarren, C. (Carlos), Knowles, J.W. (Joshua), Quertermous, T. (Thomas), Ferrucci, L. (Luigi), Tanaka, T. (Toshiko), Bis, J.C. (Joshua), Haritunians, T. (Talin), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Taylor, K.D. (Kent), Thacker, E.L. (Evan), Almgren, P. (Peter), Groop, L. (Leif), Ladenvall, C. (Claes), Boehnke, M. (Michael), Jackson, A.U. (Anne), Mohlke, K.L. (Karen), Stringham, H.M. (Heather), Tuomilehto, J. (Jaakko), Benjamin, E.J. (Emelia), Hwang, S.J., Levy, D. (Daniel), Preis, S.R., Vasan, R.S. (Ramachandran Srini), Duan, J. (Jubao), Gejman, P.V. (Pablo), Levinson, D.F. (Douglas), Sanders, A.R. (Alan), Shi, J. (Jianxin), Lips, E.H. (Esther), McKay, J.D. (James), Agudo, A. (Antonio), Barzan, L. (Luigi), Bencko, V. (Vladimir), Benhamou, S. (Simone), Castellsagué, X. (Xavier), Canova, C. (Cristina), Conway, D.I. (David), Fabianova, E. (Eleonora), Foretova, L. (Lenka), Janout, V. (Vladimir), Healy, C.M. (Claire), Holcátová, I. (Ivana), Kjaerheim, K. (Kristina), Lagiou, P., Lissowska, J. (Jolanta), Lowry, R. (Ray), MacFarlane, T.V. (Tatiana), Mates, D. (Dana), Richiardi, L. (Lorenzo), Rudnai, P. (Peter), Szeszenia-Dabrowska, N. (Neonilia), Zaridze, D., Znaor, A. (Ariana), Lathrop, M. (Mark), Brennan, P. (Paul), Bandinelli, S. (Stefania), Frayling, T.M. (Timothy), Guralnik, J.M. (Jack), Milaneschi, Y. (Yuri), Perry, J.R.B. (John), Altshuler, D. (David), Elosua, R. (Roberto), Kathiresan, S. (Sekar), Lucas, G. (Gavin), Melander, O. (Olle), O'Donnell, C.J. (Christopher), Schwartz, S.M. (Stephen), Voight, B.F. (Benjamin), Smith, A.V. (Davey), Geus, E.J.C. (Eco) de, Chanock, S.J. (Stephen), Gu, F. (Fangyi), Hankinson, S.E. (Susan), Hunter, D. (David), Chasman, D.I. (Daniel), Everett, B.M. (Brendan), Paré, G. (Guillaume), Ridker, P.M. (Paul), Li, M.D. (Ming), Maes, H.H. (Hermine), Audrain-Mcgovern, J. (Janet), Posthuma, D. (Danielle), Thornton, L.M. (Laura), Lerman, C. (Caryn), Rose, J.E. (Jed), Ioannidis, J.P.A. (John), Kraft, P. (Peter), Lin, D.Y. (Dan), Liu, J. (Jason), Muglia, P. (Pierandrea), Waterworth, D. (Dawn), Pillai, A.D. (Ajay), Middleton, L. (Lefkos), Berrettini, W. (Wade), Knouff, C.W. (Christopher), Yuan, X. (Xin), Waeber, G. (Gérard), Vollenweider, P. (Peter), Preisig, M. (Martin), Wareham, N.J. (Nick), Zhao, J.H. (Jing Hua), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Khaw, K-T. (Kay-Tee), Grundy, S.M. (Scott), Barter, P. (Phil), Mahley, R. (Robert), Kesaniemi, Y.A. (Antero), McPherson, R. (Ruth), Vincent, J. (John), Strauss, J.S. (John S), Kennedy, J. (James), Farmer, A.E. (Anne E), Mcguffin, P. (Peter), Day, R.N. (Richard), Matthews, K. (Keith), Bakke, A.B. (Arnold B.), Gulsvik, A. (Amund), Lucae, S. (Susanne), Ising, M. (Marcus), Brueckl, T. (Tanja), Horstmann, S. (Sonja), Heinrich, J. (Joachim), Lamina, C. (Claudia), Polasek, O. (Ozren), Zgaga, L. (Lina), Huffman, J.E. (Jennifer), Campbell, S. (Susan), Kooner, J.S. (Jaspal), Chambers, J.C. (John), Burnett, M.S., Devaney, J. (Joseph), Pichard, A.D., Kent, K.M. (Kenneth), Satler, L.F., Lindsay, J.M. (Joseph), Waksman, R. (Ron), Epstein, S.E. (Stephen), Wilson, J.F. (James), Wild, S.H. (Sarah), Campbell, H. (Harry), Vitart, V. (Veronique), Reilly, M.P. (Muredach), Li, M. (Mingyao), Qu, L. (Liming), Wilensky, A. (Asaf), Matthai, W. (William), Hakonarson, H. (Hakon), Rader, D.J. (Daniel), Franke, A. (Andre), Wittig, M. (Michael), Schäfer, A. (Arne), Uda, M. (Manuela), Terracciano, A., Xiao, X. (Xiangjun), Busonero, F., Scheet, P. (Paul), Schlessinger, D., Clair, D.S., Rujescu, D. (Dan), Abecasis, G.R. (Gonçalo), Grabe, H.J. (Hans Jörgen), Teumer, A. (Alexander), Völzke, H. (Henry), Petersmann, A. (Astrid), John, U. (Ulrich), Rudan, I. (Igor), Hayward, C. (Caroline), Wright, A.F. (Alan), Kolcic, I. (Ivana), Wright, B.J. (Benjamin), Balmforth, A.J. (Anthony), Anderson, C. (Carl), Ahmed, T. (Tariq), Mathew, J. (Joseph), Parkes, M. (Miles), Satsangi, J. (Jack), Caulfield, M. (Mark), Munroe, P. (Patricia), Farrall, M. (Martin), Dominiczak, A. (Anna), Worthington, H. (Helen), Thomson, W. (Wendy), Eyre, D.S. (Dylan Samuel), Barton, A. (Anne), Mooser, V. (Vincent), Francks, C. (Clyde), Thorgeirsson, T.E. (Thorgeir), Gudbjartsson, D.F. (Daniel), Sulem, P. (Patrick), Besenbacher, S. (Søren), Styrkarsdottir, U. (Unnur), Thorleifsson, G. (Gudmar), Walters, G.B. (Bragi), Furberg, H. (Helena), Sullivan, P. (Patrick), Marchini, J. (Jonathan), McCarthy, M.I. (M.), Steinthorsdottir, V. (Valgerdur), Thorsteinsdottir, U. (Unnur), Zwart, J-A. (John-Anker), Surakka, I. (Ida), Vink, J.M. (Jacqueline), Amin, N. (Najaf), Geller, F. (Frank), Rafnar, T. (Thorunn), Esko, T. (Tõnu), Walter, S. (Stefan), Gieger, C. (Christian), Rawal, R. (Rajesh), Mangino, M. (Massimo), Prokopenko, I. (Inga), Mägi, R. (Reedik), Keskitalo, K. (Kaisu), Gudjonsdottir, I.H. (Iris), Gretarsdottir, S. (Solveig), Stefansson, H. (Hreinn), Aulchenko, Y.S. (Yurii), Nelis, M. (Mari), Aben, K.K.H. (Katja), Heijer, M. (Martin) den, Soranzo, N. (Nicole), Valdes, A.M. (Ana Maria), Steves, C.J. (Claire), Uitterlinden, A.G. (André), Hofman, A. (Albert), Tönjes, A. (Anke), Kovacs, P. (Peter), Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Vogelzangs, N. (Nicole), Döring, A. (Angela), Dahmen, N. (N.), Nitz, B. (Barbara), Ripatti, S. (Samuli), Perola, M. (Markus), Kettunen, J. (Johannes), Hartikainen, A.L., Pouta, A. (Anneli), Laitinen, J. (Jaana), Isohanni, M.K. (Matti), Huei-Yi, S. (Shen), Allen, M. (Maxine), Krestyaninova, M. (Maria), Hall, A. (Anne), Thompson, J.R. (John), Oskarsson, H. (Hogni), Tyrfingsson, T. (Thorarinn), Kiemeney, L.A.L.M. (Bart), Jarvelin, M.-R. (Marjo-Riitta), Salomaa, V. (Veikko), Stumvoll, M. (Michael), Spector, T.D. (Timothy), Wichmann, H.E. (Heinz Erich), Metspalu, A. (Andres), Samani, N.J. (Nilesh), Penninx, B.W.J.H. (Brenda), Oostra, B.A. (Ben), Boomsma, D.I. (Dorret), Tiemeier, H.W. (Henning), Duijn, C.M. (Cornelia) van, Kaprio, J. (Jaakko), Gulcher, J.R. (Jeffrey), Kim, Y. (Yunjung), Dackor, J. (Jennifer), Boerwinkle, E.A. (Eric), Franceschini, N. (Nora), Ardissino, D. (Diego), Bernardinelli, L. (Luisa), Mannucci, P.M. (Pier), Mauri, F. (Francesco), Merlini, P.A. (Piera), Absher, D. (Devin), Assimes, T.L. (Themistocles), Fortmann, S.P. (Stephen), Iribarren, C. (Carlos), Knowles, J.W. (Joshua), Quertermous, T. (Thomas), Ferrucci, L. (Luigi), Tanaka, T. (Toshiko), Bis, J.C. (Joshua), Haritunians, T. (Talin), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Taylor, K.D. (Kent), Thacker, E.L. (Evan), Almgren, P. (Peter), Groop, L. (Leif), Ladenvall, C. (Claes), Boehnke, M. (Michael), Jackson, A.U. (Anne), Mohlke, K.L. (Karen), Stringham, H.M. (Heather), Tuomilehto, J. (Jaakko), Benjamin, E.J. (Emelia), Hwang, S.J., Levy, D. (Daniel), Preis, S.R., Vasan, R.S. (Ramachandran Srini), Duan, J. (Jubao), Gejman, P.V. (Pablo), Levinson, D.F. (Douglas), Sanders, A.R. (Alan), Shi, J. (Jianxin), Lips, E.H. (Esther), McKay, J.D. (James), Agudo, A. (Antonio), Barzan, L. (Luigi), Bencko, V. (Vladimir), Benhamou, S. (Simone), Castellsagué, X. (Xavier), Canova, C. (Cristina), Conway, D.I. (David), Fabianova, E. (Eleonora), Foretova, L. (Lenka), Janout, V. (Vladimir), Healy, C.M. (Claire), Holcátová, I. (Ivana), Kjaerheim, K. (Kristina), Lagiou, P., Lissowska, J. (Jolanta), Lowry, R. (Ray), MacFarlane, T.V. (Tatiana), Mates, D. (Dana), Richiardi, L. (Lorenzo), Rudnai, P. (Peter), Szeszenia-Dabrowska, N. (Neonilia), Zaridze, D., Znaor, A. (Ariana), Lathrop, M. (Mark), Brennan, P. (Paul), Bandinelli, S. (Stefania), Frayling, T.M. (Timothy), Guralnik, J.M. (Jack), Milaneschi, Y. (Yuri), Perry, J.R.B. (John), Altshuler, D. (David), Elosua, R. (Roberto), Kathiresan, S. (Sekar), Lucas, G. (Gavin), Melander, O. (Olle), O'Donnell, C.J. (Christopher), Schwartz, S.M. (Stephen), Voight, B.F. (Benjamin), Smith, A.V. (Davey), Geus, E.J.C. (Eco) de, Chanock, S.J. (Stephen), Gu, F. (Fangyi), Hankinson, S.E. (Susan), Hunter, D. (David), Chasman, D.I. (Daniel), Everett, B.M. (Brendan), Paré, G. (Guillaume), Ridker, P.M. (Paul), Li, M.D. (Ming), Maes, H.H. (Hermine), Audrain-Mcgovern, J. (Janet), Posthuma, D. (Danielle), Thornton, L.M. (Laura), Lerman, C. (Caryn), Rose, J.E. (Jed), Ioannidis, J.P.A. (John), Kraft, P. (Peter), Lin, D.Y. (Dan), Liu, J. (Jason), Muglia, P. (Pierandrea), Waterworth, D. (Dawn), Pillai, A.D. (Ajay), Middleton, L. (Lefkos), Berrettini, W. (Wade), Knouff, C.W. (Christopher), Yuan, X. (Xin), Waeber, G. (Gérard), Vollenweider, P. (Peter), Preisig, M. (Martin), Wareham, N.J. (Nick), Zhao, J.H. (Jing Hua), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Khaw, K-T. (Kay-Tee), Grundy, S.M. (Scott), Barter, P. (Phil), Mahley, R. (Robert), Kesaniemi, Y.A. (Antero), McPherson, R. (Ruth), Vincent, J. (John), Strauss, J.S. (John S), Kennedy, J. (James), Farmer, A.E. (Anne E), Mcguffin, P. (Peter), Day, R.N. (Richard), Matthews, K. (Keith), Bakke, A.B. (Arnold B.), Gulsvik, A. (Amund), Lucae, S. (Susanne), Ising, M. (Marcus), Brueckl, T. (Tanja), Horstmann, S. (Sonja), Heinrich, J. (Joachim), Lamina, C. (Claudia), Polasek, O. (Ozren), Zgaga, L. (Lina), Huffman, J.E. (Jennifer), Campbell, S. (Susan), Kooner, J.S. (Jaspal), Chambers, J.C. (John), Burnett, M.S., Devaney, J. (Joseph), Pichard, A.D., Kent, K.M. (Kenneth), Satler, L.F., Lindsay, J.M. (Joseph), Waksman, R. (Ron), Epstein, S.E. (Stephen), Wilson, J.F. (James), Wild, S.H. (Sarah), Campbell, H. (Harry), Vitart, V. (Veronique), Reilly, M.P. (Muredach), Li, M. (Mingyao), Qu, L. (Liming), Wilensky, A. (Asaf), Matthai, W. (William), Hakonarson, H. (Hakon), Rader, D.J. (Daniel), Franke, A. (Andre), Wittig, M. (Michael), Schäfer, A. (Arne), Uda, M. (Manuela), Terracciano, A., Xiao, X. (Xiangjun), Busonero, F., Scheet, P. (Paul), Schlessinger, D., Clair, D.S., Rujescu, D. (Dan), Abecasis, G.R. (Gonçalo), Grabe, H.J. (Hans Jörgen), Teumer, A. (Alexander), Völzke, H. (Henry), Petersmann, A. (Astrid), John, U. (Ulrich), Rudan, I. (Igor), Hayward, C. (Caroline), Wright, A.F. (Alan), Kolcic, I. (Ivana), Wright, B.J. (Benjamin), Balmforth, A.J. (Anthony), Anderson, C. (Carl), Ahmed, T. (Tariq), Mathew, J. (Joseph), Parkes, M. (Miles), Satsangi, J. (Jack), Caulfield, M. (Mark), Munroe, P. (Patricia), Farrall, M. (Martin), Dominiczak, A. (Anna), Worthington, H. (Helen), Thomson, W. (Wendy), Eyre, D.S. (Dylan Samuel), Barton, A. (Anne), Mooser, V. (Vincent), and Francks, C. (Clyde)
Abstract: Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10-7). These findings replicate in a second large data set (N=127 274, thereof 76 242 smokers) for both SI (P=1.2 × 10-5) and CPD (P=9.3 × 10-5). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.
Published: 2013
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21. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

Author: Valk, R.J.P. (Ralf) van der, Duijts, L. (Liesbeth), Timpson, N.J. (Nicholas), Salam, M.T. (Muhammad), Standl, E. (Eberhard), Curtin, J.A. (John), Genuneit, J. (Jon), Kerhof, M. (Marjan), Kreiner-Møller, E. (Eskil), Cáceres, A. (Alejandro), Gref, A. (Anna), Liang, L. (Liming), Taal, H.R. (Rob), Bouzigon, E. (Emmanuelle), Demenais, F. (Florence), Nadif, R. (Rachel), Ober, C. (Carole), Thompson, E.E. (Emma), Estrada Gil, K. (Karol), Hofman, A. (Albert), Uitterlinden, A.G. (André), Duijn, C.M. (Cornelia) van, Rivadeneira Ramirez, F. (Fernando), Li, X. (Xia), Eckel, R. (Renate), Berhane, K. (Kiros), Gauderman, W.J. (W James), Granell, R. (Raquel), Evans, D.M. (David), St Pourcain, B. (Beate), McArdle, W.L. (Wendy), Kemp, J.P. (John), Smith, A.V. (Davey), Tiesler, C. (Carla), Flexeder, C. (Claudia), Simpson, A. (Angela), Murray, C.S. (Clare), Fuchs, O. (Oliver), Postma, D.S. (Dirkje), Bønnelykke, K. (Klaus), Torrent, M. (Maties), Andersson, M. (Martin), Sleiman, P.M.A. (Patrick), Hakonarson, H. (Hakon), Cookson, W.O. (William), Moffatt, M.F. (Miriam), Paternoster, L. (Lavinia), Melén, E. (Erik), Sunyer, J. (Jordi), Bisgaard, H. (Hans), Koppelman, G.H. (Gerard), Ege, M. (Markus), Custovic, A. (Adnan), Heinrich, J. (Joachim), Gilliland, D.G. (Gary), Henderson, A.J. (Alexander), Jaddoe, V.W.V. (Vincent), Jongste, J.C. (Johan) de, Valk, R.J.P. (Ralf) van der, Duijts, L. (Liesbeth), Timpson, N.J. (Nicholas), Salam, M.T. (Muhammad), Standl, E. (Eberhard), Curtin, J.A. (John), Genuneit, J. (Jon), Kerhof, M. (Marjan), Kreiner-Møller, E. (Eskil), Cáceres, A. (Alejandro), Gref, A. (Anna), Liang, L. (Liming), Taal, H.R. (Rob), Bouzigon, E. (Emmanuelle), Demenais, F. (Florence), Nadif, R. (Rachel), Ober, C. (Carole), Thompson, E.E. (Emma), Estrada Gil, K. (Karol), Hofman, A. (Albert), Uitterlinden, A.G. (André), Duijn, C.M. (Cornelia) van, Rivadeneira Ramirez, F. (Fernando), Li, X. (Xia), Eckel, R. (Renate), Berhane, K. (Kiros), Gauderman, W.J. (W James), Granell, R. (Raquel), Evans, D.M. (David), St Pourcain, B. (Beate), McArdle, W.L. (Wendy), Kemp, J.P. (John), Smith, A.V. (Davey), Tiesler, C. (Carla), Flexeder, C. (Claudia), Simpson, A. (Angela), Murray, C.S. (Clare), Fuchs, O. (Oliver), Postma, D.S. (Dirkje), Bønnelykke, K. (Klaus), Torrent, M. (Maties), Andersson, M. (Martin), Sleiman, P.M.A. (Patrick), Hakonarson, H. (Hakon), Cookson, W.O. (William), Moffatt, M.F. (Miriam), Paternoster, L. (Lavinia), Melén, E. (Erik), Sunyer, J. (Jordi), Bisgaard, H. (Hans), Koppelman, G.H. (Gerard), Ege, M. (Markus), Custovic, A. (Adnan), Heinrich, J. (Joachim), Gilliland, D.G. (Gary), Henderson, A.J. (Alexander), Jaddoe, V.W.V. (Vincent), and Jongste, J.C. (Johan) de
Abstract: Background: The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood Feno values might help to define biological mechanisms related to specific asthma phenotypes. Objective: We sought to identify the genetic variants associated with childhood Feno values and their relation with asthma. Methods: Feno values were measured in children age 5 to 15 years. In 14 genome-wide association studies (N = 8,858), we examined the associations of approximately 2.5 million single nucleotide polymorphisms (SNPs) with Feno values. Subsequently, we assessed whether significant SNPs were expression quantitative trait loci in genome-wide expression data sets of lymphoblastoid cell lines (n = 1,830) and were related to asthma in a previously published genome-wide association data set (cases, n = 10,365; control subjects: n = 16,110). Results: We identified 3 SNPs associated with Feno values: rs3751972 in LYR motif containing 9 (LYRM9; P = 1.97 × 10-10) and rs944722 in inducible nitric oxide synthase 2 (NOS2; P = 1.28 × 10-9), both of which are located at 17q11.2-q12, and rs8069176 near gasdermin B (GSDMB; P = 1.88 × 10-8) at 17q12-q21. We found a cis expression quantitative trait locus for the transcript soluble galactoside-binding lectin 9 (LGALS9) that is in linkage disequilibrium with rs944722. rs8069176 was associated with GSDMB and ORM1-like 3 (ORMDL3) expression. rs8069176 at 17q12-q21, but not rs3751972 and rs944722 at 17q11.2-q12, were associated with physician-diagnosed asthma. Conclusion: This study identified 3 variants associated with Feno values, explaining 0.95% of the variance. Identification of functional SNPs and haplotypes in these regio
Published: 2013
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22. Air pollution exposure and lung function in children: The ESCAPE project

Author: Gehring, U. (Ulrike), Gruzieva, O. (Olena), Agius, R.M. (Raymond), Beelen, R.M.J. (Rob), Custovic, A. (Adnan), Cyrys, J. (Josef), Eeftens, M. (Marloes), Flexeder, C. (Claudia), Fuertes, E. (Elaine), Heinrich, J. (Joachim), Hoffmann, B. (Barbara), Jongste, J.C. (Johan) de, Kerkhof, M. (Marjan), Klümper, C. (Claudia), Korek, M. (Michal), Mölter, A. (Anna), Schultz, E.S. (Erica), Simpson, A. (Angela), Sugiri, D. (Dorothea), Svartengren, M. (Magnus), Wijga, A.H. (Alet), Pershagen, G. (Göran), Brunekreef, B. (Bert), Berg, A. (Andrea) von, Gehring, U. (Ulrike), Gruzieva, O. (Olena), Agius, R.M. (Raymond), Beelen, R.M.J. (Rob), Custovic, A. (Adnan), Cyrys, J. (Josef), Eeftens, M. (Marloes), Flexeder, C. (Claudia), Fuertes, E. (Elaine), Heinrich, J. (Joachim), Hoffmann, B. (Barbara), Jongste, J.C. (Johan) de, Kerkhof, M. (Marjan), Klümper, C. (Claudia), Korek, M. (Michal), Mölter, A. (Anna), Schultz, E.S. (Erica), Simpson, A. (Angela), Sugiri, D. (Dorothea), Svartengren, M. (Magnus), Wijga, A.H. (Alet), Pershagen, G. (Göran), Brunekreef, B. (Bert), and Berg, A. (Andrea) von
Abstract: Background: There is evidence for adverse effects of outdoor air pollution on lung function of children. Quantitative summaries
Published: 2013
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23. Common variants at 6q22 and 17q21 are associated with intracranial volume

Author: Ikram, M.A. (Arfan), Fornage, M. (Myriam), Smith, A.V. (Davey), Seshadri, S. (Sudha), Schmidt, R. (Reinhold), Debette, S. (Stéphanie), Vrooman, H.A. (Henri), Sigurdsson, S. (Stefan), Ropele, S. (Stefan), Taal, H.R. (Rob), Mook-Kanamori, D.O. (Dennis), Coker, L.H. (Laura), Longstreth Jr, W.T., Niessen, W.J. (Wiro), DeStefano, A.L. (Anita), Beiser, A. (Alexa), Zijdenbos, A.P., Struchalin, M.V. (Maksim), Jack Jr., C.R. (Clifford), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Knopman, D.S. (David), Hartikainen, A.L., Pennell, C.E. (Craig), Thiering, E. (Eelisabeth), Steegers, E.A.P. (Eric), Hakonarson, H. (Hakon), Heinrich, J. (Joachim), Palmer, C. (Cameron), Jarvelin, M.-R. (Marjo-Riitta), McCarthy, M.I. (Mark), Grant, S.F.A. (Struan), Pourcain, B.S. (Beate), Timpson, N.J. (Nicholas), Sovio, U. (Ulla), Nalls, M.A. (Michael), Au, R. (Rhoda), Hofman, A. (Albert), Gudnason, H. (Haukur), Lugt, A. (Aad) van der, Harris, T.B. (Tamara), Meeks, W.M. (William), Vernooij, M.W. (Meike), Buchem, M.A. (Mark) van, Catellier, D.J. (Diane), Jaddoe, V.W.V. (Vincent), Gudnason, V. (Vilmundur), Windham, B.G. (Gwen), Wolf, P.A. (Philip), Duijn, C.M. (Cornelia) van, Mosley, T.H. (Thomas), Launer, L.J. (Lenore), Breteler, M.M.B. (Monique), DeCarli, C. (Charles), Adair, L.S. (Linda), Ang, W.Q. (Wei), Atalay, M. (Mustafa), Beijsterveldt, C.E.M. (Toos) van, Bergen, N.E. (Nienke), Benke, P.J. (Paul), Berry, D. (Diane), Coin, L. (Lachlan), Davis, O.S.P. (Oliver S.), Elliott, P. (Paul), Flexeder, C. (Claudia), Frayling, T.M. (Timothy), Gaillard, R. (Romy), Groen-Blokhuis, M. (Maria), Goh, L.-K., Haworth, C.M.A. (Claire M.), Hadley, D. (David), Hedebrand, J. (Johannes), Hinney, A. (Anke), Hirschhorn, J.N. (Joel), Holloway, J.W. (John), Holst, J.J., Hottenga, J.J. (Jouke Jan), Horikoshi, M. (Momoko), Huikari, V. (Ville), Hypponen, E. (Elina), Kilpeläinen, T.O. (Tuomas), Kirin, M. (Mirna), Kowgier, M. (Matthew), Lakka, T.A. (Timo), Lange, L.A. (Leslie), Lawlor, D.A. (Debbie), Lehtimäki, T. (Terho), Lewin, A. (Alex), Lindgren, C.M. (Cecilia), Lindi, V. (Virpi), Maggi, R. (Reedik), Marsh, J.A. (Julie), Middeldorp, C.M. (Christel), Millwood, I.Y. (Iona), Murray, J.C. (Jeffrey), Nivard, M. (Michel), Nohr, C. (Christian), Ntalla, I. (Ioanna), Oken, E. (Emily), Panoutsopoulou, K. (Kalliope), Pararajasingham, J. (Jennifer), Rodriguez, A. (Alfredo Chapin), Salem, R.M. (Rany), Sebert, S. (Sylvain), Siitonen, N. (Niina), Strachan, D.P. (David), Teo, Y.Y. (Yik Ying), Valcárcel, B. (Beatriz), Willemsen, G.A.H.M. (Gonneke), Zeggini, E. (Eleftheria), Boomsma, D.I. (Dorret), Cooper, C. (Charles), Gillman, M.H. (Matthew), Hocher, B. (Berthold), Mohlke, K.L. (Karen), Dedoussis, G.V. (George), Ong, K.K. (Ken), Pearson, E. (Ewan), Price, T.S. (Thomas), Power, C. (Christopher), Raitakari, O. (Olli), Saw, S-M. (Seang-Mei), Scherag, A. (Andre), Simell, O. (Olli), Sørensen, T.I.A. (Thorkild), Wilson, J.F. (James), Ikram, M.A. (Arfan), Fornage, M. (Myriam), Smith, A.V. (Davey), Seshadri, S. (Sudha), Schmidt, R. (Reinhold), Debette, S. (Stéphanie), Vrooman, H.A. (Henri), Sigurdsson, S. (Stefan), Ropele, S. (Stefan), Taal, H.R. (Rob), Mook-Kanamori, D.O. (Dennis), Coker, L.H. (Laura), Longstreth Jr, W.T., Niessen, W.J. (Wiro), DeStefano, A.L. (Anita), Beiser, A. (Alexa), Zijdenbos, A.P., Struchalin, M.V. (Maksim), Jack Jr., C.R. (Clifford), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Knopman, D.S. (David), Hartikainen, A.L., Pennell, C.E. (Craig), Thiering, E. (Eelisabeth), Steegers, E.A.P. (Eric), Hakonarson, H. (Hakon), Heinrich, J. (Joachim), Palmer, C. (Cameron), Jarvelin, M.-R. (Marjo-Riitta), McCarthy, M.I. (Mark), Grant, S.F.A. (Struan), Pourcain, B.S. (Beate), Timpson, N.J. (Nicholas), Sovio, U. (Ulla), Nalls, M.A. (Michael), Au, R. (Rhoda), Hofman, A. (Albert), Gudnason, H. (Haukur), Lugt, A. (Aad) van der, Harris, T.B. (Tamara), Meeks, W.M. (William), Vernooij, M.W. (Meike), Buchem, M.A. (Mark) van, Catellier, D.J. (Diane), Jaddoe, V.W.V. (Vincent), Gudnason, V. (Vilmundur), Windham, B.G. (Gwen), Wolf, P.A. (Philip), Duijn, C.M. (Cornelia) van, Mosley, T.H. (Thomas), Launer, L.J. (Lenore), Breteler, M.M.B. (Monique), DeCarli, C. (Charles), Adair, L.S. (Linda), Ang, W.Q. (Wei), Atalay, M. (Mustafa), Beijsterveldt, C.E.M. (Toos) van, Bergen, N.E. (Nienke), Benke, P.J. (Paul), Berry, D. (Diane), Coin, L. (Lachlan), Davis, O.S.P. (Oliver S.), Elliott, P. (Paul), Flexeder, C. (Claudia), Frayling, T.M. (Timothy), Gaillard, R. (Romy), Groen-Blokhuis, M. (Maria), Goh, L.-K., Haworth, C.M.A. (Claire M.), Hadley, D. (David), Hedebrand, J. (Johannes), Hinney, A. (Anke), Hirschhorn, J.N. (Joel), Holloway, J.W. (John), Holst, J.J., Hottenga, J.J. (Jouke Jan), Horikoshi, M. (Momoko), Huikari, V. (Ville), Hypponen, E. (Elina), Kilpeläinen, T.O. (Tuomas), Kirin, M. (Mirna), Kowgier, M. (Matthew), Lakka, T.A. (Timo), Lange, L.A. (Leslie), Lawlor, D.A. (Debbie), Lehtimäki, T. (Terho), Lewin, A. (Alex), Lindgren, C.M. (Cecilia), Lindi, V. (Virpi), Maggi, R. (Reedik), Marsh, J.A. (Julie), Middeldorp, C.M. (Christel), Millwood, I.Y. (Iona), Murray, J.C. (Jeffrey), Nivard, M. (Michel), Nohr, C. (Christian), Ntalla, I. (Ioanna), Oken, E. (Emily), Panoutsopoulou, K. (Kalliope), Pararajasingham, J. (Jennifer), Rodriguez, A. (Alfredo Chapin), Salem, R.M. (Rany), Sebert, S. (Sylvain), Siitonen, N. (Niina), Strachan, D.P. (David), Teo, Y.Y. (Yik Ying), Valcárcel, B. (Beatriz), Willemsen, G.A.H.M. (Gonneke), Zeggini, E. (Eleftheria), Boomsma, D.I. (Dorret), Cooper, C. (Charles), Gillman, M.H. (Matthew), Hocher, B. (Berthold), Mohlke, K.L. (Karen), Dedoussis, G.V. (George), Ong, K.K. (Ken), Pearson, E. (Ewan), Price, T.S. (Thomas), Power, C. (Christopher), Raitakari, O. (Olli), Saw, S-M. (Seang-Mei), Scherag, A. (Andre), Simell, O. (Olli), Sørensen, T.I.A. (Thorkild), and Wilson, J.F. (James)
Abstract: During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10 -8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10 -11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10 -12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10 -3 for 6q22 and 1.2 × 10 -3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
Published: 2012
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24. Common variants at 12q15 and 12q24 are associated with infant head circumference

Author: Taal, H.R. (Rob), St Pourcain, B. (Beate), Thiering, E. (Eelisabeth), Das, S. (Shikta), Mook-Kanamori, D.O. (Dennis), Warrington, N.M. (Nicole), Kaakinen, M. (Marika), Kreiner-Møller, E. (Eskil), Bradfield, J.P. (Jonathan), Freathy, R.M. (Rachel), Geller, F. (Frank), Guxens Junyent, M. (Mònica), Cousminer, D.L. (Diana), Kerkhof, M. (Marjan), Timpson, N.J. (Nicholas), Ikram, M.A. (Arfan), Beilin, L.J. (Lawrence), Bønnelykke, K. (Klaus), Buxton, J.L. (Jessica), Charoen, P. (Pimphen), Chawes, B.L.K. (Bo Lund Krogsgaard), Eriksson, J.G. (Johan), Evans, D.M. (David), Hofman, A. (Albert), Kemp, J.P. (John), Kim, C.E. (Cecilia), Klopp, N. (Norman), Lahti, J. (Jari), Lye, S.J. (Stephen), Mcmahon, G. (George), Mentch, F.D. (Frank), Müller-Nurasyid, M. (Martina), O'Reilly, P.F. (Paul), Prokopenko, I. (Inga), Rivadeneira Ramirez, F. (Fernando), Steegers, E.A.P. (Eric), Sunyer, J. (Jordi), Tiesler, C. (Carla), Yaghootkar, H. (Hanieh), Breteler, M.M.B. (Monique), Debette, S. (Stéphanie), Fornage, M. (Myriam), Gudnason, V. (Vilmunder), Launer, L.J. (Lenore), Lugt, A. (Aad) van der, Mosley, T.H. (Thomas), Seshadri, S. (Sudha), Smith, A.V. (Albert V.), Vernooij, M.W. (Meike), Blakemore, A.I.F. (Alexandra), Chiavacci, R.M. (Rosetta), Feenstra, B. (Bjarke), Fernandez-Banet, J. (Julio), Grant, S.F.A. (Struan), Hartikainen, A.-L. (Anna-Liisa), Heijden, A.J. (Albert) van der, Iniguez, C. (Carmen), Lathrop, M. (Mark), McArdle, W.L. (Wendy), Mølgaard, A. (Anne), Newnham, J.P. (John), Palmer, L.J. (Lyle), Palotie, A. (Aarno), Pouta, A. (Anneli), Ring, S.M. (Susan), Sovio, U. (Ulla), Standl, M. (Marie), Uitterlinden, A.G. (André), Wichmann, E.H. (Erich), Vissing, N.H. (Nadja), DeCarli, C. (Charles), Duijn, C.M. (Cornelia) van, McCarthy, M.I. (M.), Koppelman, G.H. (Gerard), Estivill, X. (Xavier), Hattersley, A.T. (Andrew), Melbye, M. (Mads), Bisgaard, H. (Hans), Pennell, C.E. (Craig), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Davey-Smith, G. (George), Heinrich, J. (Joachim), Jarvelin, M.-R. (Marjo-Riitta), Jaddoe, V.W.V. (Vincent), Taal, H.R. (Rob), St Pourcain, B. (Beate), Thiering, E. (Eelisabeth), Das, S. (Shikta), Mook-Kanamori, D.O. (Dennis), Warrington, N.M. (Nicole), Kaakinen, M. (Marika), Kreiner-Møller, E. (Eskil), Bradfield, J.P. (Jonathan), Freathy, R.M. (Rachel), Geller, F. (Frank), Guxens Junyent, M. (Mònica), Cousminer, D.L. (Diana), Kerkhof, M. (Marjan), Timpson, N.J. (Nicholas), Ikram, M.A. (Arfan), Beilin, L.J. (Lawrence), Bønnelykke, K. (Klaus), Buxton, J.L. (Jessica), Charoen, P. (Pimphen), Chawes, B.L.K. (Bo Lund Krogsgaard), Eriksson, J.G. (Johan), Evans, D.M. (David), Hofman, A. (Albert), Kemp, J.P. (John), Kim, C.E. (Cecilia), Klopp, N. (Norman), Lahti, J. (Jari), Lye, S.J. (Stephen), Mcmahon, G. (George), Mentch, F.D. (Frank), Müller-Nurasyid, M. (Martina), O'Reilly, P.F. (Paul), Prokopenko, I. (Inga), Rivadeneira Ramirez, F. (Fernando), Steegers, E.A.P. (Eric), Sunyer, J. (Jordi), Tiesler, C. (Carla), Yaghootkar, H. (Hanieh), Breteler, M.M.B. (Monique), Debette, S. (Stéphanie), Fornage, M. (Myriam), Gudnason, V. (Vilmunder), Launer, L.J. (Lenore), Lugt, A. (Aad) van der, Mosley, T.H. (Thomas), Seshadri, S. (Sudha), Smith, A.V. (Albert V.), Vernooij, M.W. (Meike), Blakemore, A.I.F. (Alexandra), Chiavacci, R.M. (Rosetta), Feenstra, B. (Bjarke), Fernandez-Banet, J. (Julio), Grant, S.F.A. (Struan), Hartikainen, A.-L. (Anna-Liisa), Heijden, A.J. (Albert) van der, Iniguez, C. (Carmen), Lathrop, M. (Mark), McArdle, W.L. (Wendy), Mølgaard, A. (Anne), Newnham, J.P. (John), Palmer, L.J. (Lyle), Palotie, A. (Aarno), Pouta, A. (Anneli), Ring, S.M. (Susan), Sovio, U. (Ulla), Standl, M. (Marie), Uitterlinden, A.G. (André), Wichmann, E.H. (Erich), Vissing, N.H. (Nadja), DeCarli, C. (Charles), Duijn, C.M. (Cornelia) van, McCarthy, M.I. (M.), Koppelman, G.H. (Gerard), Estivill, X. (Xavier), Hattersley, A.T. (Andrew), Melbye, M. (Mads), Bisgaard, H. (Hans), Pennell, C.E. (Craig), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Davey-Smith, G. (George), Heinrich, J. (Joachim), Jarvelin, M.-R. (Marjo-Riitta), and Jaddoe, V.W.V. (Vincent)
Abstract: To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Published: 2012
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25. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Author: Hancock, D.B. (Dana), Artigas, M.S., Gharib, S.A. (Sina), Henry, A. (Amanda), Manichaikul, A. (Ani), Ramasamy, A. (Adaikalavan), Loth, D.W. (Daan), Imboden, M. (Medea), Koch, B. (Beate), McArdle, W.L. (Wendy), Smith, A.V. (Davey), Smolonska, J. (Joanna), Sood, A. (Akshay), Tang, W. (Wenbo), Wilk, J.B. (Jemma), Zhai, G. (Guangju), Zhao, J.H. (Jing Hua), Aschard, H. (Hugues), Burkart, K.M. (Kristin), Curjuric, I. (Ivan), Eijgelsheim, M. (Mark), Elliott, P. (Paul), Gu, X. (Xiangjun), Harris, T.B. (Tamara), Janson, C. (Christer), Homuth, G. (Georg), Hysi, P.G. (Pirro), Liu, J. (Jason), Loehr, L.R. (Laura), Lohman, K. (Kurt), Loos, R.J.F. (Ruth), Manning, A.K. (Alisa), Marciante, K. (Kristin), Obeidat, M. (Ma'en), Postma, D.S. (Dirkje), Aldrich, M.C. (Melinda), Brusselle, G.G. (Guy), Chen, T.H., Eiriksdottir, G. (Gudny), Franceschini, N. (Nora), Heinrich, J. (Joachim), Rotter, J.I. (Jerome), Wijmenga, C. (Cisca), Williams, O.D. (Dale), Hofman, A. (Albert), Laurie, C.C. (Cathy), Lumley, T. (Thomas), Morrison, A.C. (Alanna), Joubert, B.R. (Bonnie), Rivadeneira Ramirez, F. (Fernando), Couper, D.J. (David), Kritchevsky, S.B. (Stephen), Liu, Y. (YongMei), Wjst, M. (Matthias), Wain, L.V. (Louise), Vonk, J.M. (Judith), Uitterlinden, A.G. (André), Rochat, T. (Thierry), Rich, S.S. (Stephen), Psaty, B.M. (Bruce), O'Connor, G.T. (George), North, K.E. (Kari), Mirel, D. (Daniel), Meibohm, B. (Bernd), Launer, L.J. (Lenore), Khaw, K-T. (Kay-Tee), Hartikainen, A.L., Hammond, C.J. (Christopher), Gläser, S. (Sven), Marchini, J. (Jonathan), Kraft, P. (Peter), Wareham, N.J. (Nick), Völzke, H. (Henry), Stricker, B.H.Ch. (Bruno), Spector, T.D. (Timothy), Probst-Hensch, N.M. (Nicole M.), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Heckbert, S.R. (Susan), Gudnason, V. (Vilmundur), Boezen, H.M. (Marike), Barr, R.G. (Graham), Cassano, P.A. (Patricia), Strachan, D.P. (David), Fornage, M. (Myriam), Hall, I.P. (Ian), Dupuis, J. (Josée), Tobin, M.D. (Martin), London, S.J. (Stephanie), Bentley, A.R. (Amy), Hancock, D.B. (Dana), Artigas, M.S., Gharib, S.A. (Sina), Henry, A. (Amanda), Manichaikul, A. (Ani), Ramasamy, A. (Adaikalavan), Loth, D.W. (Daan), Imboden, M. (Medea), Koch, B. (Beate), McArdle, W.L. (Wendy), Smith, A.V. (Davey), Smolonska, J. (Joanna), Sood, A. (Akshay), Tang, W. (Wenbo), Wilk, J.B. (Jemma), Zhai, G. (Guangju), Zhao, J.H. (Jing Hua), Aschard, H. (Hugues), Burkart, K.M. (Kristin), Curjuric, I. (Ivan), Eijgelsheim, M. (Mark), Elliott, P. (Paul), Gu, X. (Xiangjun), Harris, T.B. (Tamara), Janson, C. (Christer), Homuth, G. (Georg), Hysi, P.G. (Pirro), Liu, J. (Jason), Loehr, L.R. (Laura), Lohman, K. (Kurt), Loos, R.J.F. (Ruth), Manning, A.K. (Alisa), Marciante, K. (Kristin), Obeidat, M. (Ma'en), Postma, D.S. (Dirkje), Aldrich, M.C. (Melinda), Brusselle, G.G. (Guy), Chen, T.H., Eiriksdottir, G. (Gudny), Franceschini, N. (Nora), Heinrich, J. (Joachim), Rotter, J.I. (Jerome), Wijmenga, C. (Cisca), Williams, O.D. (Dale), Hofman, A. (Albert), Laurie, C.C. (Cathy), Lumley, T. (Thomas), Morrison, A.C. (Alanna), Joubert, B.R. (Bonnie), Rivadeneira Ramirez, F. (Fernando), Couper, D.J. (David), Kritchevsky, S.B. (Stephen), Liu, Y. (YongMei), Wjst, M. (Matthias), Wain, L.V. (Louise), Vonk, J.M. (Judith), Uitterlinden, A.G. (André), Rochat, T. (Thierry), Rich, S.S. (Stephen), Psaty, B.M. (Bruce), O'Connor, G.T. (George), North, K.E. (Kari), Mirel, D. (Daniel), Meibohm, B. (Bernd), Launer, L.J. (Lenore), Khaw, K-T. (Kay-Tee), Hartikainen, A.L., Hammond, C.J. (Christopher), Gläser, S. (Sven), Marchini, J. (Jonathan), Kraft, P. (Peter), Wareham, N.J. (Nick), Völzke, H. (Henry), Stricker, B.H.Ch. (Bruno), Spector, T.D. (Timothy), Probst-Hensch, N.M. (Nicole M.), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Heckbert, S.R. (Susan), Gudnason, V. (Vilmundur), Boezen, H.M. (Marike), Barr, R.G. (Graham), Cassano, P.A. (Patricia), Strachan, D.P. (David), Fornage, M. (Myriam), Hall, I.P. (Ian), Dupuis, J. (Josée), Tobin, M.D. (Martin), London, S.J. (Stephanie), and Bentley, A.R. (Amy)
Published: 2012
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26. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Author: Hancock, DB, Artigas, MS, Gharib, SA, Henry, A, Manichaikul, A, Ramasamy, A, Loth, Daan, Imboden, M, Koch, B, McArdle, WL, Smith, AV, Smolonska, J, Sood, A, Tang, WB, Wilk, JB, Zhai, GJ, Zhao, JH, Aschard, H, Burkart, KM, Curjuric, I, Eijgelsheim, Mark, Elliott, P, Gu, XJ, Harris, TB, Janson, C, Homuth, G, Hysi, PG, Liu, JZ, Loehr, LR, Lohman, K, Loos, RJF, Manning, AK, Marciante, KD, Obeidat, M, Postma, DS, Aldrich, MC, Brusselle, Guy, Chen, TH, Eiriksdottir, G, Franceschini, N, Heinrich, J (Joachim), Rotter, JI, Wijmenga, C, Williams, OD, Bentley, AR, Hofman, Bert, Laurie, CC, Lumley, T, Morrison, AC, Joubert, BR, Rivadeneira, Fernando, Couper, DJ, Kritchevsky, SB, Liu, YM, Wjst, M, Wain, LV, Vonk, JM, Uitterlinden, André, Rochat, T, Rich, SS, Psaty, BM, O'Connor, GT, North, KE, Mirel, DB, Meibohm, B, Launer, LJ (Lenore), Khaw, KT, Hartikainen, AL, Hammond, CJ, Glaser, S, Marchini, J, Kraft, P, Wareham, NJ, Volzke, H, Stricker, Bruno, Spector, TD, Probst-Hensch, NM, Jarvis, D, Jarvelin, MR, Heckbert, SR, Gudnason, V, Boezen, M, Barr, RG, Cassano, PA, Strachan, DP, Fornage, M, Hall, IP, Dupuis, J, Tobin, MD, London, SJ, Hancock, DB, Artigas, MS, Gharib, SA, Henry, A, Manichaikul, A, Ramasamy, A, Loth, Daan, Imboden, M, Koch, B, McArdle, WL, Smith, AV, Smolonska, J, Sood, A, Tang, WB, Wilk, JB, Zhai, GJ, Zhao, JH, Aschard, H, Burkart, KM, Curjuric, I, Eijgelsheim, Mark, Elliott, P, Gu, XJ, Harris, TB, Janson, C, Homuth, G, Hysi, PG, Liu, JZ, Loehr, LR, Lohman, K, Loos, RJF, Manning, AK, Marciante, KD, Obeidat, M, Postma, DS, Aldrich, MC, Brusselle, Guy, Chen, TH, Eiriksdottir, G, Franceschini, N, Heinrich, J (Joachim), Rotter, JI, Wijmenga, C, Williams, OD, Bentley, AR, Hofman, Bert, Laurie, CC, Lumley, T, Morrison, AC, Joubert, BR, Rivadeneira, Fernando, Couper, DJ, Kritchevsky, SB, Liu, YM, Wjst, M, Wain, LV, Vonk, JM, Uitterlinden, André, Rochat, T, Rich, SS, Psaty, BM, O'Connor, GT, North, KE, Mirel, DB, Meibohm, B, Launer, LJ (Lenore), Khaw, KT, Hartikainen, AL, Hammond, CJ, Glaser, S, Marchini, J, Kraft, P, Wareham, NJ, Volzke, H, Stricker, Bruno, Spector, TD, Probst-Hensch, NM, Jarvis, D, Jarvelin, MR, Heckbert, SR, Gudnason, V, Boezen, M, Barr, RG, Cassano, PA, Strachan, DP, Fornage, M, Hall, IP, Dupuis, J, Tobin, MD, and London, SJ
Abstract: Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest P-JMA = 5.00 x 10(-11)), HLA-DQB1 and HLA-DQA2 (smallest P-JMA = 4.35 x 10(-9)), and KCNJ2 and SOX9 (smallest P-JMA = 1.28 x 10(-8)) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
Published: 2012

27. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Author: Freathy, R.M. (Rachel), Mook-Kanamori, D.O. (Dennis), Sovio, U. (Ulla), Prokopenko, I. (Inga), Timpson, N.J. (Nicholas), Berry, D. (Diane), Warrington, N.M. (Nicole), Widen, E. (Elisabeth), Hottenga, J.J. (Jouke Jan), Kaakinen, M. (Marika), Lange, L.A. (Leslie), Bradfield, J.P. (Jonathan), Kerkhof, M. (Marjan), Marsh, J.A. (Julie), Mägi, R. (Reedik), Chen, C. (Chao), Lyon, H.N. (Helen), Kirin, M. (Mirna), Adair, L.S. (Linda), Aulchenko, Y.S. (Yurii), Bennett, A.J. (Amanda), Borja, J.B. (Judith), Bouatia-Naji, N. (Nabila), Charoen, P. (Pimphen), Coin, L. (Lachlan), Cousminer, D.L. (Diana), Geus, E.J.C. (Eco) de, Deloukas, P. (Panagiotis), Elliott, P. (Paul), Evans, D.M. (David), Froguel, P. (Philippe), Glaser, B. (Beate), Groves, C.J. (Christopher), Hartikainen, A.L., Hassanali, N. (Neelam), Hirschhorn, J.N. (Joel), Hofman, A. (Albert), Holly, J.M.P. (Jeff), Hyppönen, E. (Elina), Kanoni, S. (Stavroula), Knight, B.A. (Bridget), Laitinen, J. (Jaana), Lindgren, C.M. (Cecilia), McArdle, W.L. (Wendy), O'Reilly, P.F. (Paul), Pennell, C.E. (Craig), Postma, D.S. (Dirkje), Pouta, A. (Anneli), Ramasamy, A. (Adaikalavan), Rayner, N.W. (Nigel William), Ring, S.M. (Susan), Rivadeneira Ramirez, F. (Fernando), Shields, B.M. (Beverley), Strachan, D.P. (David), Surakka, I. (Ida), Taanila, A. (Anja), Tiesler, C. (Carla), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Wijga, A.H. (Alet), Willemsen, G.A.H.M. (Gonneke), Zhang, H. (Haitao), Zhao, J.H. (Jing Hua), Wilson, J.F. (James), Steegers-Theunissen, R.P.M. (Régine), Hattersley, A.T. (Andrew), Hagen, K. (Knut), Peltonen, L. (Leena Johanna), Mohlke, K.L. (Karen), Grant, S.F.A. (Struan), Hakonarson, H. (Hakon), Koppelman, G.H. (Gerard), Dedoussis, G.V. (George), Heinrich, J. (Joachim), Gillman, M.W. (Matthew W.), Palmer, C. (Cameron), Frayling, T.M. (Timothy), Boomsma, D.I. (Dorret), Smith, A.V. (Davey), Power, C. (Christopher), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), McCarthy, M.I. (Mark), Freathy, R.M. (Rachel), Mook-Kanamori, D.O. (Dennis), Sovio, U. (Ulla), Prokopenko, I. (Inga), Timpson, N.J. (Nicholas), Berry, D. (Diane), Warrington, N.M. (Nicole), Widen, E. (Elisabeth), Hottenga, J.J. (Jouke Jan), Kaakinen, M. (Marika), Lange, L.A. (Leslie), Bradfield, J.P. (Jonathan), Kerkhof, M. (Marjan), Marsh, J.A. (Julie), Mägi, R. (Reedik), Chen, C. (Chao), Lyon, H.N. (Helen), Kirin, M. (Mirna), Adair, L.S. (Linda), Aulchenko, Y.S. (Yurii), Bennett, A.J. (Amanda), Borja, J.B. (Judith), Bouatia-Naji, N. (Nabila), Charoen, P. (Pimphen), Coin, L. (Lachlan), Cousminer, D.L. (Diana), Geus, E.J.C. (Eco) de, Deloukas, P. (Panagiotis), Elliott, P. (Paul), Evans, D.M. (David), Froguel, P. (Philippe), Glaser, B. (Beate), Groves, C.J. (Christopher), Hartikainen, A.L., Hassanali, N. (Neelam), Hirschhorn, J.N. (Joel), Hofman, A. (Albert), Holly, J.M.P. (Jeff), Hyppönen, E. (Elina), Kanoni, S. (Stavroula), Knight, B.A. (Bridget), Laitinen, J. (Jaana), Lindgren, C.M. (Cecilia), McArdle, W.L. (Wendy), O'Reilly, P.F. (Paul), Pennell, C.E. (Craig), Postma, D.S. (Dirkje), Pouta, A. (Anneli), Ramasamy, A. (Adaikalavan), Rayner, N.W. (Nigel William), Ring, S.M. (Susan), Rivadeneira Ramirez, F. (Fernando), Shields, B.M. (Beverley), Strachan, D.P. (David), Surakka, I. (Ida), Taanila, A. (Anja), Tiesler, C. (Carla), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Wijga, A.H. (Alet), Willemsen, G.A.H.M. (Gonneke), Zhang, H. (Haitao), Zhao, J.H. (Jing Hua), Wilson, J.F. (James), Steegers-Theunissen, R.P.M. (Régine), Hattersley, A.T. (Andrew), Hagen, K. (Knut), Peltonen, L. (Leena Johanna), Mohlke, K.L. (Karen), Grant, S.F.A. (Struan), Hakonarson, H. (Hakon), Koppelman, G.H. (Gerard), Dedoussis, G.V. (George), Heinrich, J. (Joachim), Gillman, M.W. (Matthew W.), Palmer, C. (Cameron), Frayling, T.M. (Timothy), Boomsma, D.I. (Dorret), Smith, A.V. (Davey), Power, C. (Christopher), Jaddoe, V.W.V. (Vincent), Jarvelin, M.-R. (Marjo-Riitta), and McCarthy, M.I. (Mark)
Abstract: To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birt
Published: 2010
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28. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author: Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), Weedon, M.N. (Michael), Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), and Weedon, M.N. (Michael)
Abstract: Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.
Published: 2010
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28 results on '"Heinrich, J (Joachim)"'

1. Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms

2. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

3. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

4. Erratum to: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

5. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

6. Genome-wide associations for birth weight and correlations with adult disease

7. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

8. A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

9. Heritability and genome-wide association analyses of sleep duration in children: The EAGLE consortium

10. Association of Forced Vital Capacity with the Developmental Gene NCOR2

11. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

12. Dietary Intake, FTO genetic variants, and adiposity: A combined analysis of over 16,000 children and adolescents

13. Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

14. Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

15. Genome-wide association analysis identifies six new loci associated with forced vital capacity

16. Genome-wide association analysis identifies six new loci associated with forced vital capacity

17. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

18. Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

19. Telomere length in circulating leukocytes is associated with lung function and disease

20. A common biological basis of obesity and nicotine addiction

21. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

22. Air pollution exposure and lung function in children: The ESCAPE project

23. Common variants at 6q22 and 17q21 are associated with intracranial volume

24. Common variants at 12q15 and 12q24 are associated with infant head circumference

25. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

26. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

27. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

28. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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28 results on '"Heinrich, J (Joachim)"'

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