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The article discusses the need for a comprehensive and systematic approach to pediatric stroke care and research in Germany. The project PRiSMA aims to establish a nationwide pediatric stroke registry to collect data on various aspects of the disease, including clinical presentation, risk factors, diagnostics, therapy, and outcomes. The registry will also involve international collaboration, with plans to include patients from Austria and the Netherlands. PRiSMA aims to consolidate expertise and enable future research projects through a multidisciplinary approach, and a satellite study using genetic sequencing is already in preparation. [Extracted from the article]

This article discusses a case study of a 10-year-old girl who experienced a near-drowning accident and subsequently developed severe systemic mycosis, a fungal infection. The girl experienced various complications, including abscess-forming pneumonia, osteomyelitis, and meningitis. She also developed intracranial involvement with meningoencephalitis and cerebral lesions, as well as neurovascular involvement with vessel stenosis. The article highlights the challenges in treating childhood arterial ischemic stroke as a complication of severe systemic mycosis and emphasizes the importance of collaboration between specialists in pediatric neurology, infectious diseases, hemostaseology, and neuroradiology for successful treatment. [Extracted from the article]

This article, published in the journal Neuropediatrics, explores the association between migraine and muscular hyperalgesia in young adults. The study focuses on the myofascial involvement of neck muscles and uses point-of-care measures like algometry and ultrasound to assess alterations in the upper trapezius muscle (UTM) in migraine patients compared to healthy controls. The results show that migraine patients have a higher frequency and duration of neck pain and lower pressure pain thresholds above the UTM. The study suggests that assessing muscular involvement in headache patients is important for treatment and monitoring. [Extracted from the article]

This article, published in the journal Neuropediatrics, explores the feasibility of using instrumented gait analysis to detect impaired dynamic postural control in children after mild traumatic brain injury (mTBI). The study involved 37 participants aged 13.32 ± 3.31 years, with an average time since TBI of 5.35 ± 2.92 years. The participants performed gait testing tasks using a smartphone application, and gait parameters such as step length, step cadence, gait velocity, and center of mass displacement were recorded. The results showed that instrumented gait analysis is a reliable diagnostic tool for assessing impairments in dynamic postural control in children and adolescents with mTBI. [Extracted from the article]

This article, published in the journal Neuropediatrics, discusses the results of a study examining balance after mild traumatic brain injury (mTBI) in children and adolescents. The study used various assessments, including instrumented balance error scoring system (BESS) and markerless 3D posturography, to measure postural control in participants at different time points after mTBI. The preliminary analysis showed changes in balance performance over time, particularly in more challenging testing conditions. The authors suggest that markerless 3D posturography could be a valuable tool for monitoring recovery after pediatric mTBI and providing personalized advice to prevent re-trauma and minimize long-term effects. [Extracted from the article]

This article, published in the journal Neuropediatrics, explores the benefits of repetitive neuromuscular magnetic stimulation (rNMS) in pediatric posttraumatic headache (PTH) patients. The study found that rNMS sessions targeting the upper trapezius muscle resulted in a significant decrease in maximum headache intensity and a trend towards lower minimum intensity. Additionally, patients experienced a reduction in hyperalgesia above the trapezius muscle. The authors suggest that rNMS treatment could be a beneficial noninvasive and non-pharmaceutical option for pediatric PTH patients. Further research is needed to confirm these findings. [Extracted from the article]

Background/Objectives: Evidence regarding the effect of n-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation during pregnancy on offspring's neurodevelopment is not conclusive. Subjects/Methods: In this analysis, the effect of a reduced n-6:n-3 LCPUFA ratio in the diet of pregnant/lactating women (1.2 g n-3 LCPUFA together with an arachidonic acid (AA)-balanced diet between 15th wk of gestation-4 months postpartum vs control diet) on child neurodevelopment at 4 and 5 years of age was assessed. A child development inventory (CDI) questionnaire and a hand movement test measuring mirror movements (MMs) were applied and the association with cord blood LCPUFA concentrations examined. Results: CDI questionnaire data, which categorizes children as 'normal', 'borderline' or 'delayed' in different areas of development, showed no significant evidence between study groups at 4 (n=119) and 5 years (n=130) except for the area 'letters' at 5 years of age (P=0.043). Similarly, the results did not strongly support the hypothesis that the intervention has a beneficial effect on MMs (for example, at 5 years: dominant hand, fast: adjusted mean difference, -0.08 (-0.43, 0.26); P=0.631). Children exposed to higher cord blood concentrations of docosahexaenoic acid, eicosapentaenoic acid and AA, as well as a lower ratio of n-6:n-3 fatty acids appeared to show beneficial effects on MMs, but these results were largely not statistically significant. Conclusions: Our results do not show clear benefits or harms of a change in the n-6:n-3 LCPUFA ratio during pregnancy on offspring's neurodevelopment at preschool age. Findings on cord blood LCPUFAs point to a potential influence on offspring development., Author(s): C Brei [sup.1] , L Stecher [sup.1] , S Brunner [sup.1] , R Ensenauer [sup.2] [sup.3] , F Heinen [sup.4] , P D Wagner [sup.5] , J Hermsdörfer [sup.5] [...]