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When one starts working philologically with historical manuscripts, one faces important first questions involving authorship, writers’ hands andthe history of documenttransmission. These issues are especially thorny with documents remaining outside the established canon, such as privatemanuscripts, aboutwhichwehave very restrictedtext-externalinformation. In this area – so we argue – it is especially fruitful to employ a mixed-methods approach, combiningtailored automatic methods from image recognition/analysis with philological and linguistic knowledge.Whileimage analysis captureswriters’ hands, linguistic/philological research mainly addressestextual authorship;thetwo cross-fertilize and obtain a coherent interpretation which may then be evaluated against the available text-external historical evidence. Departingfrom our ‘lab case’,whichis a corpus of unedited Czechmanuscriptsfromthe archive of a small 18th century migrant community, the Herrnhuter Brüdergemeine (Brethren parish) in Berlin-Neukölln, our project has developed an assistance system which aids philologists in working with digitized (scanned) hand-written historical sources. We present its application and discuss its general potential and methodological implications.

The concentration of dissolved oxygen in aquatic systems helps to regulate biodiversity1,2, nutrient biogeochemistry3, greenhouse gas emissions4, and the quality of drinking water5. The long-term declines in dissolved oxygen concentrations in coastal and ocean waters have been linked to climate warming and human activity6,7, but little is known about the changes in dissolved oxygen concentrations in lakes. Although the solubility of dissolved oxygen decreases with increasing water temperatures, long-term lake trajectories are difficult to predict. Oxygen losses in warming lakes may be amplified by enhanced decomposition and stronger thermal stratification8,9 or oxygen may increase as a result of enhanced primary production10. Here we analyse a combined total of 45,148 dissolved oxygen and temperature profiles and calculate trends for 393 temperate lakes that span 1941 to 2017. We find that a decline in dissolved oxygen is widespread in surface and deep-water habitats. The decline in surface waters is primarily associated with reduced solubility under warmer water temperatures, although dissolved oxygen in surface waters increased in a subset of highly productive warming lakes, probably owing to increasing production of phytoplankton. By contrast, the decline in deep waters is associated with stronger thermal stratification and loss of water clarity, but not with changes in gas solubility. Our results suggest that climate change and declining water clarity have altered the physical and chemical environment of lakes. Declines in dissolved oxygen in freshwater are 2.75 to 9.3 times greater than observed in the world’s oceans6,7 and could threaten essential lake ecosystem services2,3,5,11.

Importance: The administration of a high fraction of oxygen following return of spontaneous circulation in out-of-hospital cardiac arrest may increase reperfusion brain injury. Objective: To determine whether targeting a lower oxygen saturation in the early phase of postresuscitation care for out-of-hospital cardiac arrest improves survival at hospital discharge. Design, Setting, and Participants: This multicenter, parallel-group, randomized clinical trial included unconscious adults with return of spontaneous circulation and a peripheral oxygen saturation (Spo2) of at least 95% while receiving 100% oxygen. The trial was conducted in 2 emergency medical services and 15 hospitals in Victoria and South Australia, Australia, between December 11, 2017, and August 11, 2020, with data collection from ambulance and hospital medical records (final follow-up date, August 25, 2021). The trial enrolled 428 of a planned 1416 patients. Interventions: Patients were randomized by paramedics to receive oxygen titration to achieve an oxygen saturation of either 90% to 94% (intervention; n = 216) or 98% to 100% (standard care; n = 212) until arrival in the intensive care unit. Main Outcomes and Measures: The primary outcome was survival to hospital discharge. There were 9 secondary outcomes collected, including hypoxic episodes (Spo2<90%) and prespecified serious adverse events, which included hypoxia with rearrest. Results: The trial was stopped early due to the COVID-19 pandemic. Of the 428 patients who were randomized, 425 were included in the primary analysis (median age, 65.5 years; 100 [23.5%] women) and all completed the trial. Overall, 82 of 214 patients (38.3%) in the intervention group survived to hospital discharge compared with 101 of 211 (47.9%) in the standard care group (difference, -9.6% [95% CI, -18.9% to -0.2%]; unadjusted odds ratio, 0.68 [95% CI, 0.46-1.00]; P =.05). Of the 9 prespecified secondary outcomes collected during hospital stay, 8 showed no significant d

This chapter reviews the morphodynamics of open-ocean barrier systems, synthesizing classic studies, current scientific knowledge, and future research directions regarding 14 barrier provinces worldwide. Within a coastal tectonic framework, it addresses: (1) Amero-trailing-edge coasts (USA’s New England coast, Mid-Atlantic Bight coast, North Carolina Outer Banks, Georgia Bight coast, Florida Atlantic coast; Brazil’s Santa Catarina coast; Europe’s German Bight coast; Australia’s southern and western coasts); (2) marginal-sea coasts (USA’s Florida Gulf Coast; Gulf Coast of Louisiana, Mississippi, and Alabama; Texas Gulf Coast; Australia’s eastern coast); and (3) collision coasts (USA’s Alaskan Pacific coast, Japan’s and New Zealand’s coasts). This chapter also provides a glossary, important conclusions, specific recommendations regarding future coastal research, and a robust, current set of references.