178 results on '"Hein, Nadine"'
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2. Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling
3. Targeting the ribosome to treat multiple myeloma
4. The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma
5. CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci.
6. Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling
7. Targeting the ribosome to treat multiple myeloma
8. Purification of Mouse Embryonic Fibroblasts (MEFs)
9. Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies
10. Supplementary Figure S1 from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
11. Supplementary Methods from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
12. Supplementary Figure S2 from Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
13. Data from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
14. Supplementary Methods, Tables S1 - S3, Figure Legends from Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
15. Data from Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
16. Supplementary Tables S1-S7 from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
17. Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
18. Real-time biochemical-free targeted sequencing of RNA species with RISER
19. Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
20. Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer
21. The nucleolus: an emerging target for cancer therapy
22. Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
23. Phosphorylation by Cdk2 Is Required for Myc to Repress Ras-Induced Senescence in Cotransformation
24. The Ribosomal Gene Loci—The Power behind the Throne
25. The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461
26. Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice
27. Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway
28. The Nucleolus and Ribosomal Genes in Aging and Senescence
29. rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461
30. Regulation of the MAD1 promoter by G-CSF
31. First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
32. Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
33. First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
34. MODULATION OF RNA POLYMERASE I TRANSCRIPTION IN NORMAL AND MALIGNANT HAEMATOPOIESIS
35. Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
36. Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM
37. A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia
38. Novel combination therapy targeting rDNA transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM
39. High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology
40. High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology
41. New Roles for the Nucleolus in Health and Disease
42. A novel modifier gene of the p53-mediated nucleolar stress response activated by ribosomal protein depletion
43. Role of plasma cells in Waldenström macroglobulinaemia
44. Abstract IA10: Drugging the ribosome at the level of synthesis and translation to treat solid and hematologic cancers
45. Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
46. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
47. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
48. Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
49. A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes
50. Abstract A31: Elucidating mechanisms that cooperate with the therapeutic inhibition of RNA polymerase I to treat MYC-driven hematological malignancies
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