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1. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O'Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D'alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Hernandez, Isabel Bascaran, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, Aydin, Zeynep, Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., and Rotmans, Joris I.

Published
2022
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5. A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Author

Pisoni, Ronald, Robinson, Bruce, Johnson, David, Cho, Yeoungjee, Wong, Muh Geot, Mather, Amanda, Cooper, Bruce, Devuyst, Olivier, Morelle, Johann, Goffin, Eric, Bammens, Bert, Bovy, Philippe, Margetts, Peter, Perl, Jeffrey, Taylor, Paul, Jain, Arsh, Jassal, Vanita, Stenvinkel, Peter, Heimburger, Olof, Kuan, Ying, Harron, Camille, Dasgupta, Indranil, Stoves, John, Akbani, Habib, Abeygunasekara, Sumith, Sharples, Edward, Mead, Paul, Hayat, Amer, Morgan, Neal, Cramp, Hilary, Robertson, Susan, Fielding, Richard, Brown, Edwina, Collinson, Helen, Ande, Pravene, Doulton, Tim, MacDougall, Iain, Cairns, Hugh, Vilar, Enric, Vardhan, Anand, Chess, James, Sandhu, Kanwaljit, Wilkie, Martin, McHaffie, Gavin, Lewis, Robert, Kamesh, Lavanya, Buck, Kate, Peel, Robert, Taylor, Jo, Johnston, Paul, Leung, Janson, Bingham, Coralie, Anijeet, Hameed, Asghar, Ramzana, Ranakrishna, Satish, Nair, Sunita, Iggo, Neil, Lewis, David, Udayaraj, Uday, Dawson, Susan, Woordrow, Graham, Chandrasekar, Thangavelu, Hamer, Rizwan, Barratt, Jonathan, Baines, Richard, Davies, Simon, Donovan, Kieron, Jones, Colin, Ynares, Christina, Dukes, Carl, Imam, Talha H., Corapi, Kristin, Nigwekar, Sagar, Khawar, Osman, Weiner, Daniel, Lau, Wei Ling, Harley, Kevin, Ghaffari, Arshia, Saxena, Ramesh, Abraham, Josephine, Mehrotra, Rajnish, Himmelfarb, Jonathan, Cavanaugh, Kerri L., Golper, Thomas A., Burkart, John M., Pirkle, James L., Miller, Brent, Jang, Judy, Turner, Jeffrey, Stanaway, Ian B., Jarvik, Gail P., Lambie, Mark, Johnson, David W., and Davies, Simon J.

Published
2021
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6. Longitudinal serum bicarbonate and mortality risk in older patients with advanced chronic kidney disease: analyses from the EQUAL cohort.

Author

Lombardi, Gianmarco, Chesnaye, Nicholas C, Caskey, Fergus J, Dekker, Friedo W, Evans, Marie, Heimburger, Olof, Pippias, Maria, Torino, Claudia, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Gambaro, Giovanni, Stel, Vianda S, Jager, Kitty J, Ferraro, Pietro Manuel, and investigators, the EQUAL study

Subjects
CHRONIC kidney failure, GLOMERULAR filtration rate, OLDER patients, MORTALITY, REGRESSION analysis
Abstract

Background We aimed to explore the relationship between serum bicarbonate (SBC) and mortality in advanced chronic kidney disease (CKD) during three distinct treatment periods: during the pre-kidney replacement therapy (KRT) period, during the transition phase surrounding the start of KRT (transition-CKD) and during KRT. Methods Using the European QUALity Study on treatment in advanced CKD (EQUAL) cohort, which includes patients aged ≥65 years and estimated glomerular filtration rate (eGFR) ≤20 mL/min/1.73 m2 from six European countries, we explored the association between longitudinal SBC and all-cause mortality in three separate CKD populations: pre-KRT, transition-CKD and in the KRT populations, using multivariable time-dependent Cox regression models. We evaluated effect modification by pre-specified variables on the relationship between SBC and mortality. Results We included 1485 patients with a median follow-up of 2.9 (interquartile range 2.7) years, during which 529 (35.6%) patients died. A U-shaped relationship between SBC levels and all-cause mortality was observed in the pre-KRT population (P  = .03). Low cumulative exposure, defined as the area under the SBC trajectory before KRT initiation, was associated with increased mortality risk after transitioning to KRT (P  = .01). Similarly, in the KRT population, low SBC levels showed a trend towards increased mortality risk (P  = .13). We observed effect modification by subjective global assessment category (P -value for interaction = .02) and KRT (P -value for interaction = .02). Conclusions A U-shaped relationship describes the association between SBC and mortality in the advanced CKD pre-KRT population, whereas in the KRT population a trend towards an increased mortality risk was observed for low SBC levels. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease

Author

Magagnoli, Lorenza, Cozzolino, Mario, Evans, Marie, Caskey, Fergus J., Dekker, Friedo W., Torino, Claudia, Szymczak, Maciej, Drechsler, Christiane, Pippias, Maria, Vilasi, Antonio, Janse, Roemer J., Krajewska, Magdalena, Stel, Vianda S., Jager, Kitty J., Chesnaye, Nicholas C., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Butti, Alessandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Abaterusso, Cataldo, Somma, Chiara, D'alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2024
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9. Bioimpedance analysis in patients with chronic kidney disease

Author

Eyre, Sintra, Stenberg, Jenny, Wallengren, Ola, Keane, David M., Avesani, Carla, Bosaeus, Ingvar, Clyne, Naomi, Heimburger, Olof, Indurain, Ainhoa, Johansson, Ann-Cathrine, Lindholm, Bengt, Seoane, Fernando, Trondsen, Mia, SWEBIS network, Eyre, Sintra, Stenberg, Jenny, Wallengren, Ola, Keane, David M., Avesani, Carla, Bosaeus, Ingvar, Clyne, Naomi, Heimburger, Olof, Indurain, Ainhoa, Johansson, Ann-Cathrine, Lindholm, Bengt, Seoane, Fernando, Trondsen, Mia, and SWEBIS network

Published
2023
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12. Clinical and patient-reported trajectories at end-of-life in older patients with advanced CKD.

Author

Chesnaye, Nicholas C, Caskey, Fergus J, Dekker, Friedo W, Rooij, Esther N M de, Evans, Marie, Heimburger, Olof, Pippias, Maria, Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Jager, Kitty J, and investigators, the EQUAL study

Subjects
OLDER patients, CHRONIC kidney failure, BLOOD pressure, PATIENT reported outcome measures
Abstract

Background We explore longitudinal trajectories of clinical indicators, patient-reported outcomes, and hospitalizations, in the years preceding death in a population of older patients with advanced chronic kidney disease (CKD). Methods The EQUAL study is a European observational prospective cohort study with an incident eGFR <20 ml/min per 1.73 m2 and ≥65 years of age. The evolution of each clinical indicator was explored using generalized additive models during the 4 years preceding death. Results We included 661 decedents with a median time to death of 2.0 years (IQR 0.9–3.2). During the years preceding death, eGFR, Subjective Global Assessment score, and blood pressure declined, with accelerations seen at 6 months preceding death. Serum hemoglobin, hematocrit, cholesterol, calcium, albumin, and sodium values declined slowly during follow-up, with accelerations observed between 6 and 12 months preceding death. Physical and mental quality of life declined linearly throughout follow-up. The number of reported symptoms was stable up to 2 years prior to death, with an acceleration observed at 1 year prior to death. The rate of hospitalization was stable at around one hospitalization per person year, increasing exponentially at 6 months preceding death. Conclusions We identified clinically relevant physiological accelerations in patient trajectories that began ∼6 to 12 months prior to death, which are likely multifactorial in nature, but correlate with a surge in hospitalizations. Further research should focus on how to effectively use this knowledge to inform patient and family expectations, to benefit the planning of (end-of-life) care, and to establish clinical alert systems. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Ramspek, Chava L., primary, Boekee, Rosemarijn, additional, Evans, Marie, additional, Heimburger, Olof, additional, Snead, Charlotte M., additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Krajewska, Magdalena, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Chesnaye, Nicholas C., additional, Jager, Kitty J., additional, Dekker, Friedo W., additional, Snoeijs, Maarten G.J., additional, Rotmans, Joris I., additional, van Diepen, Merel, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Musiała, Aleksandra, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Woodman, Alistair, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Jonsson, Andreas, additional, Schneider, Andreas, additional, Pignataro, Angelo, additional, Schrander, Anita, additional, Torp, Anke, additional, McKeever, Anna, additional, Szymczak, Anna, additional, Blom, Anna-Lena, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Ullah, Asad, additional, McLaren, Barbara, additional, van Dam, Bastiaan, additional, Iwig, Beate, additional, Antonio, Bellasi, additional, Di Iorio, Biagio Raffaele, additional, Rogland, Björn, additional, Perras, Boris, additional, Alessandra, Butti, additional, Harron, Camille, additional, Wallquist, Carin, additional, Siegert, Carl, additional, Barrett, Carla, additional, Gaillard, Carlo, additional, Garofalo, Carlo, additional, Abaterusso, Cataldo, additional, Beerenhout, Charles, additional, O'Toole, Charlotte, additional, Somma, Chiara, additional, Marx, Christian, additional, Summersgill, Christina, additional, Blaser, Christof, additional, D'alessandro, Claudia, additional, Emde, Claudia, additional, Zullo, Claudia, additional, Pozzi, Claudio, additional, Geddes, Colin, additional, Verburgh, Cornelis, additional, Bergamo, Daniela, additional, Ciurlino, Daniele, additional, Motta, Daria, additional, Glowski, Deborah, additional, McGlynn, Deborah, additional, Vargas, Denes, additional, Krieter, Detlef, additional, Russo, Domenico, additional, Fuchs, Dunja, additional, Sands, Dympna, additional, Hoogeveen, Ellen, additional, Irmler, Ellen, additional, Dimény, Emöke, additional, Favaro, Enrico, additional, Platen, Eva, additional, Olczyk, Ewelina, additional, Hoorn, Ewout, additional, Vigotti, Federica, additional, Ansali, Ferruccio, additional, Conte, Ferruccio, additional, Cianciotta, Francesca, additional, Giacchino, Francesca, additional, Cappellaio, Francesco, additional, Pizzarelli, Francesco, additional, Sundelin, Fredrik, additional, Uhlin, Fredrik, additional, Greco, Gaetano, additional, Roy, Geena, additional, Bigatti, Giada, additional, Marinangeli, Giancarlo, additional, Cabiddu, Gianfranca, additional, Hirst, Gillian, additional, Fumagalli, Giordano, additional, Caloro, Giorgia, additional, Piccoli, Giorgina, additional, Capasso, Giovanbattista, additional, Gambaro, Giovanni, additional, Tognarelli, Giuliana, additional, Bonforte, Giuseppe, additional, Conte, Giuseppe, additional, Toscano, Giuseppe, additional, Del Rosso, Goffredo, additional, Welander, Gunilla, additional, Augustyniak-Bartosik, Hanna, additional, Boots, Hans, additional, Schmidt-Gürtler, Hans, additional, King, Hayley, additional, McNally, Helen, additional, Schlee, Hendrik, additional, Boom, Henk, additional, Naujoks, Holger, additional, Masri-Senghor, Houda, additional, Murtagh, Hugh, additional, Rayner, Hugh, additional, Miśkowiec-Wiśniewska, Ilona, additional, Schlee, Ines, additional, Capizzi, Irene, additional, Hernandez, Isabel Bascaran, additional, Baragetti, Ivano, additional, Manitius, Jacek, additional, Turner, Jane, additional, Eijgenraam, Jan-Willem, additional, Kooman, Jeroen, additional, Beige, Joachim, additional, Pondel, Joanna, additional, Wilcox, Joanne, additional, Berdeprado, Jocelyn, additional, Röthele, Jochen, additional, Wong, Jonathan, additional, Rotmans, Joris, additional, Banda, Joyce, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Jędrzejak, Kamila, additional, Nowańska, Katarzyna, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Jones, Kirsteen, additional, Anding-Rost, Kirsten, additional, Gröntoft, Knut-Christian, additional, Oldrizzi, Lamberto, additional, Haydock, Lesley, additional, Vogt, Liffert, additional, Wilkinson, Lily, additional, Gesualdo, Loreto, additional, Schramm, Lothar, additional, Biancone, Luigi, additional, Nowak, Łukasz, additional, Raasveld, Maarten, additional, Durlik, Magdalena, additional, Magnano, Manuela, additional, Vervloet, Marc, additional, Ricardi, Marco, additional, Carmody, Margaret, additional, Di Bari, Maria, additional, Laudato, Maria, additional, Sirico, Maria Luisa, additional, Stendahl, Maria, additional, Svensson, Maria, additional, Weetman, Maria, additional, van Buren, Marjolijn, additional, Joinson, Martin, additional, Ferraresi, Martina, additional, Dutton, Mary, additional, Matthews, Michael, additional, Provenzano, Michele, additional, Hopf, Monika, additional, Malaguti, Moreno, additional, Wuttke, Nadja, additional, Morgan, Neal, additional, Palmieri, Nicola, additional, Frischmuth, Nikolaus, additional, Bleakley, Nina, additional, Murrone, Paola, additional, Cockwell, Paul, additional, Leurs, Paul, additional, Roderick, Paul, additional, Voskamp, Pauline, additional, Kashioulis, Pavlos, additional, Ichtiaris, Pawlos, additional, Blankestijn, Peter, additional, Kirste, Petra, additional, Schulz, Petra, additional, Mason, Phil, additional, Kalra, Philip, additional, Cirillo, Pietro, additional, Dattolo, Pietro, additional, Acampora, Pina, additional, Sajith, Rincy, additional, Nigro, Rita, additional, Boero, Roberto, additional, Scarpioni, Roberto, additional, Sicoli, Rosa, additional, Malandra, Rosella, additional, Aign, Sabine, additional, Cäsar, Sabine, additional, van Esch, Sadie, additional, Chapman, Sally, additional, Biribauer, Sandra, additional, Navjee, Santee, additional, Crosbie, Sarah, additional, Brown, Sharon, additional, Tickle, Sheila, additional, Manan, Sherin, additional, Röser, Silke, additional, Savoldi, Silvana, additional, Bertoli, Silvio, additional, Borrelli, Silvio, additional, Boorsma, Siska, additional, Heidenreich, Stefan, additional, Melander, Stefan, additional, Maxia, Stefania, additional, Maffei, Stefano, additional, Mangano, Stefano, additional, Palm, Stephanie, additional, Konings, Stijn, additional, Mathavakkannan, Suresh, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Dorota, Szyszkowska, additional, Cicchetti, Teresa, additional, Nieszporek, Teresa, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Rappa, Tiziana, additional, Almquist, Tora, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Jensen, Ulrika, additional, Palazzo, Valentina, additional, De Simone, Walter, additional, Seeger, Wolfgang, additional, Kuan, Ying, additional, Heleniak, Zbigniew, additional, and Aydin, Zeynep, additional

Published
2022
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15. Interleukin-6-to-Albumin Ratio as a Superior Predictor of Mortality in End-Stage Kidney Disease Patients.

Author

li, xiejia, Qureshi, Abdul Rashid, Suliman, Mohamed E., Heimburger, Olof, Barany, Peter, Stenvinkel, Peter, and Lindholm, Bengt

Subjects
CHRONIC kidney failure, SURVIVAL rate, RECEIVER operating characteristic curves, SERUM albumin, GLOMERULAR filtration rate
Abstract

Introduction: In patients with chronic kidney disease (CKD), high interleukin-6 (IL-6) and low albumin circulating concentrations are associated with worse outcomes. We examined the IL-6-to-albumin ratio (IAR) as a predictor of risk of death in incident dialysis patients. Methods: In 428 incident dialysis patients (median age 56 years, 62% men, 31% diabetes mellitus, 38% cardiovascular disease [CVD]), plasma IL-6 and albumin were measured at baseline to calculate IAR. We compared the discrimination of IAR with other risk factors for predicting 60-month mortality using receiver operating characteristic curve (ROC) and analyzed the association of IAR with mortality using Cox regression analysis. We divided patients into IAR tertiles and analyzed: (1) cumulative incidence of mortality and the association of IAR with mortality risk in Fine-Gray analysis, taking kidney transplantation as competing risk and (2) the restricted mean survival time (RMST) to 60-month mortality and differences of RMST (∆RMST) between IAR tertiles to describe quantitative differences of survival time. Results: For all-cause mortality, the area under the ROC curve (AUC) for IAR was 0.700, which was greater than for IL-6 and albumin separately, while for CV mortality, the AUC for IAR (0.658) showed negligible improvement over IL-6 and albumin separately. In Cox regression analysis, IAR was significantly associated with all-cause mortality but not with CV mortality. Both high versus low and middle versus low tertiles of IAR associated with higher risk of all-cause mortality, subdistribution hazard ratio of 2.22 (95% CI 1.40–3.52) and 1.85 (95% CI 1.16–2.95), respectively, after adjusting for age, sex, diabetes mellitus, CVD, smoking, and estimated glomerular filtration rate. ∆RMST at 60 months showed significantly shorter survival time in middle and high IAR tertiles compared with low IAR tertile for all-cause mortality. Conclusions: Higher IAR was independently associated with significantly higher all-cause mortality risk in incident dialysis patients. These results suggest that IAR may provide useful prognostic information in patients with CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Associations between depressive symptoms and disease progression in older patients with chronic kidney disease:Results of the EQUAL study

Author

Eveleens Maarse, Boukje C., Chesnaye, Nicholas C., Schouten, Robbert, Michels, Wieneke M., Bos, Willem Jan W., Szymczak, MacIej, Krajewska, Magdalena, Evans, Marie, Heimburger, Olof, Caskey, Fergus J., Wanner, Christoph, Jager, Kitty J., Dekker, Friedo W., Meuleman, Yvette, Eveleens Maarse, Boukje C., Chesnaye, Nicholas C., Schouten, Robbert, Michels, Wieneke M., Bos, Willem Jan W., Szymczak, MacIej, Krajewska, Magdalena, Evans, Marie, Heimburger, Olof, Caskey, Fergus J., Wanner, Christoph, Jager, Kitty J., Dekker, Friedo W., and Meuleman, Yvette

Abstract

Background: Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods: CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m2) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0-100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results: Overall kidney function decline in 1326 patients was -0.12 mL/min/1.73 m2/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03-1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions: There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men.

Published
2022

17. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., Rotmans, Joris I., van Diepen, Merel, Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., Rotmans, Joris I., and van Diepen, Merel

Abstract

Introduction: Predicting the timing and occurrence of kidney replacement therapy (KRT), cardiovascular events, and death among patients with advanced chronic kidney disease (CKD) is clinically useful and relevant. We aimed to externally validate a recently developed CKD G4+ risk calculator for these outcomes and to assess its potential clinical impact in guiding vascular access placement. Methods: We included 1517 patients from the European Quality (EQUAL) study, a European multicentre prospective cohort study of nephrology-referred advanced CKD patients aged ≥65 years. Model performance was assessed based on discrimination and calibration. Potential clinical utility for timing of referral for vascular access placement was studied with diagnostic measures and decision curve analysis (DCA). Results: The model showed a good discrimination for KRT and “death after KRT,” with 2-year concordance (C) statistics of 0.74 and 0.76, respectively. Discrimination for cardiovascular events (2-year C-statistic: 0.70) and overall death (2-year C-statistic: 0.61) was poorer. Calibration was fairly accurate. Decision curves illustrated that using the model to guide vascular access referral would generally lead to less unused arteriovenous fistulas (AVFs) than following estimated glomerular filtration rate (eGFR) thresholds. Conclusion: This study shows moderate to good predictive performance of the model in an older cohort of nephrology-referred patients with advanced CKD. Using the model to guide referral for vascular access placement has potential in combating unnecessary vascular surgeries.

Published
2022

18. Association of Longitudinal High-Sensitivity Troponin T With Mortality in Patients With Chronic Kidney Disease

Author

Chesnaye, Nicholas C., Al-Sodany, Ehab, Szummer, Karolina, Barany, Peter, Heimburger, Olof, Almquist, Tora, Melander, Stefan, Uhlin, Fredrik, Dekker, Friedo, Wanner, Christoph, Jager, Kitty J., Evans, Marie, Chesnaye, Nicholas C., Al-Sodany, Ehab, Szummer, Karolina, Barany, Peter, Heimburger, Olof, Almquist, Tora, Melander, Stefan, Uhlin, Fredrik, Dekker, Friedo, Wanner, Christoph, Jager, Kitty J., and Evans, Marie

Abstract

BACKGROUND Cardiac troponin T (cTnT) is associated with mortality in chronic kidney disease (CKD). However, the association between longitudinal cTnT measurements and survival has not previously been assessed. OBJECTIVES This study determined whether various parameterizations of longitudinal cTnT measurements were associated with patient survival in the older population with advanced CKD. METHODS The EQUAL (European QUALity) study is an observational prospective cohort study that includes subjects with stage 4-5 CKD aged $65 years and not on dialysis. The study includes 176 participants in Sweden, where longitudinal information of cTnT was collected. The study uses joint models for longitudinal and time-to-event data to assess the longitudinal association between cTnT and survival. RESULTS There were 927 cTnT measurements (median 6 per patient) collected over a median follow-up of 2.4 years. The overall 5-year survival was 57% (95% CI: 46%-69%). Longitudinally measured cTnT was associated with mortality risk, with every SD increase in cTnT, at any time point, associated with a 3.3-fold increase in mortality risk (HR: 3.3; 95% CI: 2.5-4.6). The slope of the cTnT trajectory was also associated with increased mortality risk (HR: 3.2; 95% CI: 2.06.0), as was the area under the cTnT trajectory (HR: 4.2; 95% CI: 2.6-7.2), which reflected the cumulative cTnT exposure. CONCLUSIONS Longitudinally measured cTnT is independently associated with mortality risk in older patients with stage 4 and 5 CKD, which suggests that monitoring patients with cTnT could be a valuable tool for the identification of subjects with a high mortality risk., Funding Agencies|European Renal Association European Dialysis and Transplant Association (ERA-EDTA); Dutch Kidney Foundation [SB 142]

Published
2022
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19. Reply to ‘Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL Study)’

Author

Eveleens Maarse, Boukje C, primary, Chesnaye, Nicholas C, additional, Schouten, Robbert, additional, Michels, Wieneke M, additional, Bos, Willem Jan W, additional, Szymczak, Maciej, additional, Krajewska, Magdalena, additional, Evans, Marie, additional, Heimburger, Olof, additional, Caskey, Fergus J, additional, Wanner, Christoph, additional, Jager, Kitty J, additional, Dekker, Friedo W, additional, and Meuleman, Yvette, additional

Published
2022
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20. Additional file 2 of Converting from face-to-face to postal follow-up and its effects on participant retention, response rates and errors: lessons from the EQUAL study in the UK

Author

Gates, Emer, Hole, Barnaby, Hayward, Samantha, Chesnaye, Nicholas C., Meuleman, Yvette, Dekker, Friedo W., Evans, Marie, Heimburger, Olof, Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Jager, Kitty J., Roderick, Paul, and Caskey, Fergus

Abstract

Additional file 2: Infographic showing the content (black) and error rate (red) throughout the EFU patient questionnaire.

Published
2022
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21. Additional file 1 of Converting from face-to-face to postal follow-up and its effects on participant retention, response rates and errors: lessons from the EQUAL study in the UK

Author

Gates, Emer, Hole, Barnaby, Hayward, Samantha, Chesnaye, Nicholas C., Meuleman, Yvette, Dekker, Friedo W., Evans, Marie, Heimburger, Olof, Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Jager, Kitty J., Roderick, Paul, and Caskey, Fergus

Subjects
urogenital system
Abstract

Additional file 1: Decision-making in kidney disease questionnaire.

Published
2022
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22. Does pre-emptive transplantation versus post start of dialysis transplantation with a kidney from a living donor improve outcomes after transplantation? A systematic literature review and position statement by the Descartes Working Group and ERBP

Author

Abramowicz, Daniel, Hazzan, Marc, Maggiore, Umberto, Peruzzi, Licia, Cochat, Pierre, Oberbauer, Rainer, Haller, Maria C., Van Biesen, Wim, Abramowicz, Daniel, Maggiore, Umberto, Budde, Klemens, Dudley, Chris, Hazzan, Marc, Klinger, Marian, Oberbauer, Rainer, Pascual, Julio, Schwartz, Soren, Viklicky, Ondrej, Cannata, Jorge, Cochat, Pierre, Covic, Adrian, Delvecchio, Lucia, Eckardt, Kai Uwe, Fouque, Denis, Fox, Jonathan, Heimburger, Olof, Jager, Kitty, Lindley, Elisabeth, Marti, Anna, Nagler, Evi, Oberbauer, Rainer, Spasovski, Goce, Tattersall, James, Van Biesen, Wim, Vanholder, Raymond, Wanner, Christoph, Wheeler, David, Withers, William, Wiecek, Andrzej, and Zoccali, Carmine

Published
2016
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23. Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min)

Author

Bilo, Henk, Coentrão, Luis, Couchoud, Cécile, Covic, Adrian, De Sutter, Johan, Drechsler, Christiane, Gnudi, Luigi, Goldsmith, David, Heaf, James, Heimburger, Olof, Jager, Kitty J., Nacak, Hakan, Soler, Maria José, Van Huffel, Liesbeth, Tomson, Charlie, Van Laecke, Steven, Weekers, Laurent, Wieçek, Andrzej, Bolignano, Davide, Haller, Maria, Nagler, Evi, Nistor, Ionut, van der Veer, Sabine, and Van Biesen, Wim

Published
2015
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24. A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Author

Mehrotra, Rajnish, primary, Stanaway, Ian B., additional, Jarvik, Gail P., additional, Lambie, Mark, additional, Morelle, Johann, additional, Perl, Jeffrey, additional, Himmelfarb, Jonathan, additional, Heimburger, Olof, additional, Johnson, David W., additional, Imam, Talha H., additional, Robinson, Bruce, additional, Stenvinkel, Peter, additional, Devuyst, Olivier, additional, Davies, Simon J., additional, Pisoni, Ronald, additional, Johnson, David, additional, Cho, Yeoungjee, additional, Wong, Muh Geot, additional, Mather, Amanda, additional, Cooper, Bruce, additional, Goffin, Eric, additional, Bammens, Bert, additional, Bovy, Philippe, additional, Margetts, Peter, additional, Taylor, Paul, additional, Jain, Arsh, additional, Jassal, Vanita, additional, Kuan, Ying, additional, Harron, Camille, additional, Dasgupta, Indranil, additional, Stoves, John, additional, Akbani, Habib, additional, Abeygunasekara, Sumith, additional, Sharples, Edward, additional, Mead, Paul, additional, Hayat, Amer, additional, Morgan, Neal, additional, Cramp, Hilary, additional, Robertson, Susan, additional, Fielding, Richard, additional, Brown, Edwina, additional, Collinson, Helen, additional, Ande, Pravene, additional, Doulton, Tim, additional, MacDougall, Iain, additional, Cairns, Hugh, additional, Vilar, Enric, additional, Vardhan, Anand, additional, Chess, James, additional, Sandhu, Kanwaljit, additional, Wilkie, Martin, additional, McHaffie, Gavin, additional, Lewis, Robert, additional, Kamesh, Lavanya, additional, Buck, Kate, additional, Peel, Robert, additional, Taylor, Jo, additional, Johnston, Paul, additional, Leung, Janson, additional, Bingham, Coralie, additional, Anijeet, Hameed, additional, Asghar, Ramzana, additional, Ranakrishna, Satish, additional, Nair, Sunita, additional, Iggo, Neil, additional, Lewis, David, additional, Udayaraj, Uday, additional, Dawson, Susan, additional, Woordrow, Graham, additional, Chandrasekar, Thangavelu, additional, Hamer, Rizwan, additional, Barratt, Jonathan, additional, Baines, Richard, additional, Davies, Simon, additional, Donovan, Kieron, additional, Jones, Colin, additional, Ynares, Christina, additional, Dukes, Carl, additional, Corapi, Kristin, additional, Nigwekar, Sagar, additional, Khawar, Osman, additional, Weiner, Daniel, additional, Lau, Wei Ling, additional, Harley, Kevin, additional, Ghaffari, Arshia, additional, Saxena, Ramesh, additional, Abraham, Josephine, additional, Mehrotra, Rajnish, additional, Cavanaugh, Kerri L., additional, Golper, Thomas A., additional, Burkart, John M., additional, Pirkle, James L., additional, Miller, Brent, additional, Jang, Judy, additional, and Turner, Jeffrey, additional

Published
2021
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25. Converting From Face-to-face to Postal Follow-up and Its Effects on Participant Retention, Response Rates and Errors: Lessons from the EQUAL study in the UK.

Author

Gates, Emer Regina, primary, Hole, Barnaby, additional, Hayward, Samantha, additional, Chesnaye, Nicholas C, additional, Meuleman, Yvette, additional, Dekker, Friedo W, additional, Evans, Marie, additional, Heimburger, Olof, additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Jager, Kitty J, additional, Roderick, Paul, additional, and Caskey, Fergus, additional

Published
2021
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28. A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Author

Mehrotra, Rajnish, Stanaway, Ian B, Jarvik, Gail P, Lambie, Mark, Morelle, Johann, Perl, Jeffrey, Himmelfarb, Jonathan, Heimburger, Olof, Johnson, David W, Imam, Talha H, Robinson, Bruce, Stenvinkel, Peter, Devuyst, Olivier, Davies, Simon J, Pisoni, Ronald, Johnson, David, Cho, Yeoungjee, Wong, Muh Geot, Mather, Amanda, Cooper, Bruce, Goffin, Eric, Bammens, Bert, Bovy, Philippe, Margetts, Peter, Taylor, Paul, Jain, Arsh, et al, and University of Zurich

Subjects
Nephrology, 570 Life sciences, biology, 610 Medicine & health, 10052 Institute of Physiology
Published
2021
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29. Factors determining choice of dialysisi modality among patients initiating dialysis. results of the peridialysis study

Author

Heaf, James G., Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan Vestergaard, Sorensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inge, Zilinskiene, Alanta, Randers, Else, Lokkegaard, Niels, Ots-Rosenberg, Mai, Kjellevold, Stig Arne, Kampmann, Jan Dominik, Rogland, Bjorn, Laegreid, Inger Karin, Heimburger, Olof, and Lindholm, Bengt

Published
2020
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30. Factors associated with increased mortality after dialysis initiation. results of the peridialysis study

Author

Heaf, James G., Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan Vestergaard, Sorensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inge, Zilinskiene, Alanta, Randers, Else, Lokkegaard, Niels, Ots-Rosenberg, Mai, Kjellevold, Stig Arne, Kampmann, Jan Dominik, Rogland, Bjorn, Laegreid, Inger Karin, Heimburger, Olof, and Lindholm, Bengt

Published
2020
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31. A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Mehrotra, Rajnish, Stanaway, Ian B, Jarvik, Gail P, Lambie, Mark, Morelle, Johann, Perl, Jeffrey, Himmelfarb, Jonathan, Heimburger, Olof, Johnson, David W, Imam, Talha H, Robinson, Bruce, Stenvinkel, Peter, Devuyst, Olivier, Davies, Simon J, Bio-PD Consortium, Goffin, Eric, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Mehrotra, Rajnish, Stanaway, Ian B, Jarvik, Gail P, Lambie, Mark, Morelle, Johann, Perl, Jeffrey, Himmelfarb, Jonathan, Heimburger, Olof, Johnson, David W, Imam, Talha H, Robinson, Bruce, Stenvinkel, Peter, Devuyst, Olivier, Davies, Simon J, Bio-PD Consortium, and Goffin, Eric

Abstract

Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that common genetic variants are associated with variability in PSTR. Of the 3561 participants from 69 centers in six countries, 2850 with complete data were included in a genome-wide association study. PSTR was defined as the four-hour dialysate/plasma creatinine ratio from the first peritoneal equilibration test after starting PD. Heritability of PSTR was estimated using genomic-restricted maximum-likelihood analysis, and the association of PSTR with a genome-wide polygenic risk score was also tested. The mean four hour dialysate/plasma creatinine ratio in participants was 0.70. In 2212 participants of European ancestry, no signal reached genome-wide significance but 23 single nucleotide variants at four loci demonstrated suggestive associations with PSTR. Meta-analysis of the 2850 ancestry stratified regressions revealed five single nucleotide variants at four loci with suggestive correlations with PSTR. Association across ancestry strata was consistent for rs28644184 at the KDM2B locus. The estimated heritability of PSTR was 19% and a significant permuted model polygenic risk score was associated with PSTR. Thus, this genome-wide association study of patients receiving peritoneal dialysis bolsters evidence for a genetic contribution to inter-individual variability in PSTR.

Published
2021

32. Suboptimal dialysis initiation is associated with comorbidities and uraemia progression rate but not with estimated glomerular filtration rate

Author

Heaf, James, Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan V, Sørensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inga, Zilinskiene, Alanta, Randers, Else, Løkkegaard, Niels, Ots-rosenberg, Mai, Kjellevold, Stig, Kampmann, Jan Dominik, Rogland, Björn, Lagreid, Inger, Heimburger, Olof, Lindholm, Bengt, Heaf, James, Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan V, Sørensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inga, Zilinskiene, Alanta, Randers, Else, Løkkegaard, Niels, Ots-rosenberg, Mai, Kjellevold, Stig, Kampmann, Jan Dominik, Rogland, Björn, Lagreid, Inger, Heimburger, Olof, and Lindholm, Bengt

Abstract

Background Despite early referral of uraemic patients to nephrological care, suboptimal dialysis initiation (SDI) remains a common problem associated with increased morbimortality. We hypothesized that SDI is related to pre-dialysis care. Methods In the ‘Peridialysis’ study, time and reasons for dialysis initiation (DI), clinical and biochemical data and centre characteristics were registered during the pre- and peri-dialytic period for 1583 end-stage kidney disease patients starting dialysis over a 3-year period at 15 nephrology departments in the Nordic and Baltic countries to identify factors associated with SDI. Results SDI occurred in 42%. Risk factors for SDI were late referral, cachexia, comorbidity (particularly cardiovascular), hypoalbuminaemia and rapid uraemia progression. Patients with polycystic renal disease had a lower incidence of SDI. High urea and C-reactive protein levels, acidosis and other electrolyte disorders were markers of SDI, independently of estimated glomerular filtration rate (eGFR). SDI patients had higher eGFR than non-SDI patients during the pre-dialysis period, but lower eGFR at DI. eGFR as such did not predict SDI. Patients with comorbidities had higher eGFR at DI. Centre practice and policy did not associate with the incidence of SDI. Conclusions SDI occurred in 42% of all DIs. SDI was associated with hypoalbuminaemia, comorbidity and rate of eGFR loss, but not with the degree of renal failure as assessed by eGFR.

Published
2021

33. Choice of dialysis modality among patients initiating dialysis: results of the Peridialysis study

Author

Heaf, James, Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan V, Sørensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inge, Zilinskiene, Alanta, Randers, Else, Løkkegaard, Niels, Ots-Rosenberg, Mai, Kjellevold, Stig, Kampmann, Jan Dominik, Rogland, Björn, Lagreid, Inger, Heimburger, Olof, Lindholm, Bengt, Heaf, James, Heiro, Maija, Petersons, Aivars, Vernere, Baiba, Povlsen, Johan V, Sørensen, Anette Bagger, Clyne, Naomi, Bumblyte, Inge, Zilinskiene, Alanta, Randers, Else, Løkkegaard, Niels, Ots-Rosenberg, Mai, Kjellevold, Stig, Kampmann, Jan Dominik, Rogland, Björn, Lagreid, Inger, Heimburger, Olof, and Lindholm, Bengt

Abstract

Background In patients with end-stage kidney disease (ESKD), home dialysis offers socio-economic and health benefits compared with in-centre dialysis but is generally underutilized. We hypothesized that the pre-dialysis course and institutional factors affect the choice of dialysis modality after dialysis initiation (DI). Methods The Peridialysis study is a multinational, multicentre prospective observational study assessing the causes and timing of DI and consequences of suboptimal DI. Clinical and biochemical data, details of the pre-dialytic course, reasons for DI and causes of the choice of dialysis modality were registered. Results Among 1587 included patients, 516 (32.5%) were judged unsuitable for home dialysis due to contraindications [384 ( 24.2%)] or no assessment [106 (6.7%); mainly due to late referral and/or suboptimal DI] or death [26 (1.6%)]. Older age, comorbidity, late referral, suboptimal DI, acute illness and rapid loss of renal function associated with unsuitability. Of the remaining 1071 patients, 700 (65.4%) chose peritoneal dialysis (61.7%) or home haemodialysis (HD; 3.6%), while 371 (34.6%) chose in-centre HD. Somatic differences between patients choosing home dialysis and in-centre dialysis were minor; factors linked to the choice of in-centre dialysis were late referral, suboptimal DI, acute illness and absence of a ‘home dialysis first’ institutional policy. Conclusions Given a personal choice with shared decision making, 65.4% of ESKD patients choose home dialysis. Our data indicate that the incidence of home dialysis potentially could be further increased to reduce the incidence of late referral and unplanned DI and, in acutely ill patients, by implementing an educational programme after improvement of their clinical condition.

Published
2021

35. First-year mortality in incident dialysis patients: results of the Peridialysis study

Author

Heaf, James, primary, Heiro, Maija, additional, Petersons, Aivars, additional, Vernere, Baiba, additional, Povlsen, Johan V, additional, Sørensen, Anette Bagger, additional, Clyne, Naomi, additional, Bumblyte, Inga, additional, Zilinskiene, Alanta, additional, Randers, Else, additional, Løkkegaard, Niels, additional, Rosenberg, Mai, additional, Kjellevold, Stig, additional, Kampmann, Jan Dominik, additional, Rogland, Björn, additional, Lagreid, Inger, additional, Heimburger, Olof, additional, and Lindholm, Bengt, additional

Published
2021
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37. Symptom Burden before and after Dialysis Initiation in Older Patients

Author

de Rooij, Esther N.M., Meuleman, Yvette, de Fijter, Johan W., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Dekker, Friedo W., Hoogeveen, Ellen K., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Dekker, Friedo, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Jager, Kitty, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Chesnaye, Nicholas, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Szymczak, Maciej, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Caskey, Fergus, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2022
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38. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

Author

Breit, Samuel N., Carrero, Juan J., Tsai, Vicky Wang-Wei, Yagoutifam, Nasreen, Luo, Wei, Kuffner, Tamara, Bauskin, Asne R., Wu, Liyun, Jiang, Lele, Barany, Peter, Heimburger, Olof, Murikami, Mary-Ann, Apple, Fred S., Marquis, Christopher P., Macia, Laurence, Lin, Shu, Sainsbury, Amanda, Herzog, Herbert, Law, Matthew, Stenvinkel, Peter, and Brown, David A.

Published
2012
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41. Choice of dialysis modality among patients initiating dialysis: results of the Peridialysis study

Author

Heaf, James, primary, Heiro, Maija, additional, Petersons, Aivars, additional, Vernere, Baiba, additional, Povlsen, Johan V, additional, Sørensen, Anette Bagger, additional, Clyne, Naomi, additional, Bumblyte, Inge, additional, Zilinskiene, Alanta, additional, Randers, Else, additional, Løkkegaard, Niels, additional, Ots-Rosenberg, Mai, additional, Kjellevold, Stig, additional, Kampmann, Jan Dominik, additional, Rogland, Björn, additional, Lagreid, Inger, additional, Heimburger, Olof, additional, and Lindholm, Bengt, additional

Published
2020
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42. Suboptimal dialysis initiation is associated with comorbidities and uraemia progression rate but not with estimated glomerular filtration rate

Author

Heaf, James, primary, Heiro, Maija, additional, Petersons, Aivars, additional, Vernere, Baiba, additional, Povlsen, Johan V, additional, Sørensen, Anette Bagger, additional, Clyne, Naomi, additional, Bumblyte, Inga, additional, Zilinskiene, Alanta, additional, Randers, Else, additional, Løkkegaard, Niels, additional, Ots-Rosenberg, Mai, additional, Kjellevold, Stig, additional, Kampmann, Jan Dominik, additional, Rogland, Björn, additional, Lagreid, Inger, additional, Heimburger, Olof, additional, and Lindholm, Bengt, additional

Published
2020
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48. Associations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study.

Author

Maarse, Boukje C Eveleens, Chesnaye, Nicholas C, Schouten, Robbert, Michels, Wieneke M, Bos, Willem Jan W, Szymczak, Maciej, Krajewska, Magdalena, Evans, Marie, Heimburger, Olof, Caskey, Fergus J, Wanner, Christoph, Jager, Kitty J, Dekker, Friedo W, Meuleman, Yvette, and Investigators, EQUAL Study

Subjects
MENTAL depression, CHRONIC kidney failure, OLDER patients, SYMPTOMS, CHRONICALLY ill
Abstract

Background Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m2) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0–100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results Overall kidney function decline in 1326 patients was –0.12 mL/min/1.73 m2/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03–1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men. [ABSTRACT FROM AUTHOR]

Published
2022
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