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6. New and Updated Recommendations for the Treatment of Juvenile Idiopathic Arthritis–Associated Uveitis and Idiopathic Chronic Anterior Uveitis

Author

Foeldvari, Ivan, Maccora, Ilaria, Petrushkin, Harry, Rahman, Najiha, Anton, Jordi, de Boer, Joke, Calzada‐Hernández, Joan, Carreras, Elisa, Diaz, Jesus, Edelsten, Clive, Angeles‐Han, Sheila T., Heiligenhaus, Arnd, Miserocchi, Elisabetta, Nielsen, Susan, Saurenmann, Rotraud K., Stuebiger, Nicole, Baquet‐Walscheid, Karoline, Furst, Daniel, and Simonini, Gabriele

Published
2023
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7. Hintergrund/therapeutische Grundrezepte

Author

Pleyer, Uwe, Becker, Matthias D., Chronopoulos, Argyrios, Kötter, Ina, Salchow, Daniel J., Thurau, Stephan, Szentmáry, Nóra, Seitz, Berthold, Walscheid, Karoline, Tappeiner, Christoph, Heiligenhaus, Arnd, and Pleyer, Uwe, editor

Published
2021
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10. Crystallin β-b2 promotes retinal ganglion cell protection in experimental autoimmune uveoretinitis.

Author

Bauer, Dirk, Böhm, Michael R. R., Xiaoyu Wu, Bo Wang, Jalilvand, Tida Viola, Busch, Martin, Kasper, Maren, Brockhaus, Katrin, Wildschütz, Lena, Melkonyan, Harutyun, Laffer, Björn, Zu Hörste, Gerd Meyer, Heiligenhaus, Arnd, and Thanos, Solon

Abstract

Crystallin ßb2 (crybb2) is upregulated in regenerating retinas and in various pathological conditions of the retina, including uveoretinitis. However, the role of crybb2 in this disease is largely unknown. Therefore, we used recombinant crybb2 (rcrybb2) as intravitreal treatment of B10.RIII mice prior to immunization with human interphotoreceptor retinoid-binding protein peptide 161-180 (hIRBPp161-180) in complete Freund's adjuvant (CFA) and concomitant injection of pertussis toxin (PTX) to induce experimental autoimmune uveoretinitis (EAU). In naïve mice, more beta III-tubulin (TUBB3) + and RNA-binding protein with multiple splicing (RBPMS) + cells were found in the ganglion cell layer of the retina than in EAU eyes, suggesting a loss of retinal ganglion cells (RGC) during the development of EAU. At the same time, the number of glial fibrillary acidic protein (GFAP) + cells increased in EAU eyes. RGCs were better protected in EAU eyes treated with rcrybb2, while the number of GFAP+ cells decreased. However, in retinal flatmounts, both retinal ganglion cells and retinal endothelial cells stained positive for TUBB3, indicating that TUBB3 is present in naïve B10. RIII mouse eyes not exclusive to RGCs. A significant decline in the number of RBPMS-positive retinal ganglion cells was observed in retinal flatmounts from EAU retinas in comparison to naïve retinas or EAU retinas with intravitreal rcrybb2 treatment. Whereas no significant decrease in TUBB3 levels was detected using Western blot and RT-qPCR, GFAP level, as a marker for astrocytes, increased in EAU mice compared to naïve mice. Level of Bax and Bcl2 in the retina was altered by treatment, suggesting better cell survival and inhibition of apoptosis. Furthermore, our histologic observations of the eyes showed no change in the incidence and severity of EAU, nor was the immune response affected by intravitreal rcrybb2 treatment. Taken together, these results suggest that intravitreal injection of rcrybb2 reduces retinal RGC death during the course of EAU, independent of local or systemic autoimmune responses. In the future, treating posterior uveitis with rcrybb2 to protect RGCs may offer a promising novel therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Surgical Glaucoma Treatment in Patients with Juvenile Idiopathic Arthritis-Associated Uveitis: Results after Trabeculectomy or Ahmed Glaucoma Valve Implantation.

Author

Glandorf, Karen, Rothaus, Kai, Baquet-Walscheid, Karoline, Heinz, Carsten, and Heiligenhaus, Arnd

Subjects
TRABECULECTOMY, IDIOPATHIC diseases, JUVENILE idiopathic arthritis, GLAUCOMA, UVEITIS, LOG-rank test
Abstract

Patients with juvenile idiopathic arthritis (JIA) associated uveitis (JIAU) are at risk for secondary glaucoma, frequently requiring surgical management. We compared the success rates for trabeculectomy (TE) and Ahmed glaucoma valve (AGV) implantation. We conducted a retrospective analysis of TE (45 eyes), primary AGV (pAGV) (7 eyes), or secondary AGV (sAGV) implantation after TE (11 eyes) in JIAU at the 2-year follow-up. All groups achieved significant pressure reduction. After 1 year, the overall success rate was higher in the Ahmed groups (p = 0.03). After adjusting the p-value according to Benjamin Hochberg, there is no significant difference between the groups in the Kaplan–Meier, despite a significant logrank test between all groups (p = 0.0194) and a better performance in the Ahmed groups. Slightly better success rates were achieved with pAGV in managing JIAU patients with glaucoma refractory to medical treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Beneficial Effect of Upadacitinib in a Refractory Course of Scleritis: A Case Report.

Author

Baquet-Walscheid, Karoline, Heinz, Carsten, and Heiligenhaus, Arnd

Subjects
SCLERITIS, THERAPEUTICS, TREATMENT failure, TREATMENT effectiveness, KINASE inhibitors
Abstract

Noninfectious scleritis typically takes a chronic course, and systemic corticosteroids or disease-modifying anti-rheumatic drug (DMARD) treatment may be inevitable for a prolonged period. Janus kinase (JAK) inhibitors are a relatively new therapeutic option for inflammatory diseases, and three cases of successful treatment of scleritis with tofacitinib, a substance targeting JAK-1 and -3, have been published up to now. We here describe the case of a 51-years-old female patient with bilateral anterior and posterior scleritis who, after treatment failure of multiple DMARDs, finally achieved clinical quiescence of disease under treatment with upadacitinib, a selective JAK-1 inhibitor. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Juvenile Idiopathic Arthritis

Author

Heiligenhaus, Arnd, Tappeiner, Christoph, Heinz, Carsten, Foeldvari, Ivan, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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27. Uveitis in Children

Author

Heiligenhaus, Arnd, Heinz, Carsten, Walscheid, Karoline, Foeldvari, Ivan, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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28. New and updated recommendations for the treatment of juvenile idiopathic arthritis associated uveitis and idiopathic chronic anterior uveitis

Author

MS Oogheelkunde, Infection & Immunity, Foeldvari, Ivan, Maccora, Ilaria, Petrushkin, Harry, Rahman, Najiha, Anton, Jordi, de Boer, Joke, Calzada-Hernández, Joan, Carreras, Elisa, Diaz, Jesus, Edelsten, Clive, Angeles-Han, Sheila T., Heiligenhaus, Arnd, Miserocchi, Elisabetta, Nielsen, Susan, Saurenmann, Rotraud K., Stuebiger, Nicole, Baquet-Walscheid, Karoline, Furst, Daniel, Simonini, Gabriele, MS Oogheelkunde, Infection & Immunity, Foeldvari, Ivan, Maccora, Ilaria, Petrushkin, Harry, Rahman, Najiha, Anton, Jordi, de Boer, Joke, Calzada-Hernández, Joan, Carreras, Elisa, Diaz, Jesus, Edelsten, Clive, Angeles-Han, Sheila T., Heiligenhaus, Arnd, Miserocchi, Elisabetta, Nielsen, Susan, Saurenmann, Rotraud K., Stuebiger, Nicole, Baquet-Walscheid, Karoline, Furst, Daniel, and Simonini, Gabriele

Published
2023

29. Correction to: Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)

Author

Foeldvari, Ivan, Klotsche, Jens, Simonini, Gabriele, Edelsten, Clive, Angeles-Han, Sheila T., Bangsgaard, Regitze, de Boer, Joke, Brumm, Gabriele, Torrent, Rosa Bou, Constantin, Tamas, DeLibero, Cinzia, Diaz, Jesus, Gerloni, Valeria Maria, Guedes, Margarida, Heiligenhaus, Arnd, Kotaniemi, Kaisu, Leinonen, Sanna, Minden, Kirsten, Miranda, Vasco, Miserocchi, Elisabetta, Nielsen, Susan, Niewerth, Martina, Pontikaki, Irene, de Vicuna, Carmen Garcia, Zilhao, Carla, Yeh, Steven, and Anton, Jordi

Published
2020
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30. Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)

Author

Foeldvari, Ivan, Klotsche, Jens, Simonini, Gabriele, Edelsten, Clive, Angeles-Han, Sheila T., Bangsgaard, Regitze, de Boer, Joke, Brumm, Gabriele, Torrent, Rosa Bou, Constantin, Tamas, DeLibero, Cinzia, Diaz, Jesus, Gerloni, Valeria Maria, Guedes, Margarida, Heiligenhaus, Arnd, Kotaniemi, Kaisu, Leinonen, Sanna, Minden, Kirsten, Miranda, Vasco, Miserocchi, Elisabetta, Nielsen, Susan, Niewerth, Martina, Pontikaki, Irene, de Vicuna, Carmen Garcia, Zilhao, Carla, Yeh, Steven, and Anton, Jordi

Published
2019
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33. Zur Versorgungssituation und konservativen Therapie des okulären vernarbenden Schleimhautpemphigoids in Deutschland

Author

Yaïci, Rémi, primary, Roth, Mathias, additional, Juergens, Lukas, additional, Al Nawaiseh, Sami, additional, Burkhard, Dick, additional, Besgen, Volker, additional, Fuest, Matthias, additional, Girbardt, Christian, additional, Hampel, Ulrike, additional, Heichel, Jens, additional, Heiligenhaus, Arnd, additional, Herwig-Carl, Martina C, additional, Kakkassery, Vinodh, additional, Kontopoulou, Kalliopi, additional, Löffler, Karin U, additional, Maier, Philip Christian, additional, Nölle, Bernhard, additional, Pach, Johanna, additional, Paul, Sebastian, additional, Pleyer, Uwe, additional, Pöllmann, Michael, additional, Saeger, Mark, additional, Schmidt, Enno, additional, Siebelmann, Sebastian, additional, Sokolenko, Ekatarina, additional, Strudel, Lisa, additional, Stübiger, Nicole, additional, Tarhan, Melih, additional, Theuersbacher, Johanna, additional, van Oterendorp, Christian, additional, Walker, Marten, additional, Wiecha, Carolin, additional, Wykrota, Agata Anna, additional, and Geerling, Gerd, additional

Published
2023
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34. Challenges and concepts in the diagnosis and management of ocular graft-versus-host disease

Author

Tappeiner, Christoph, Heiligenhaus, Arnd, Halter, Joerg P., Miserocchi, Elisabetta, Bandello, Francesco, and Goldblum, David

Subjects
Medizin
Abstract

Graft-versus-host disease (GVHD) is characterized by tissue inflammation in the host following an allogeneic hematopoietic cell transplantation (HCT). The pathophysiology is complex and only incompletely understood yet. Donor lymphocyte interaction with the histocompatibility antigens of the host plays a crucial role in the pathogenesis of the disease. Inflammation may affect multiple organs and tissues, e.g., the gastrointestinal tract, liver, lung, fasciae, vaginal mucosa, and the eye. Subsequently, alloreactive donor-derived T and B lymphocytes may lead to severe inflammation of the ocular surface (i.e., cornea and conjunctiva) and the eyelids. Furthermore, fibrosis of the lacrimal gland may lead to severe dry eye. This review focuses on ocular GVHD (oGVHD) and provides an overview of current challenges and concepts in the diagnosis and management of oGVHD. Ophthalmic manifestations, diagnostic procedures, grading of severity and recommendations for ophthalmic examination intervals are provided. Management of ocular surface disease with lubricants, autologous serum eye drops, topical anti-inflammatory agents and systemic treatment options are described based on the current evidence. Ocular surface scarring and corneal perforation are severe complications of oGVHD. Therefore, ophthalmic screening and interdisciplinary treatment approaches are highly relevant to improve the quality of life of patients and to prevent potentially irreversible visual loss. CA Tappeiner

Published
2023

35. Nicht-infektiös

Author

Brandauer, Karin, Heiligenhaus, Arnd, Heinz, Carsten, Hennig, Maren, Mackensen, Friederike, Minden, Kirsten, Niewerth, Martina, Pleyer, Uwe, Schwenger, Vedat, Winterhalter, Sibylle, Zeisbrich, Markus, and Pleyer, Uwe, editor

Published
2014
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36. Okuläre Oberfläche – nicht infektiös

Author

Chronopoulos, Argyrios, Dietrich-Ntoukas, Tina, Heiligenhaus, Arnd, Heinz, Carsten, Messmer, Elisabeth M., Mockenhaupt, Maja, Pleyer, Uwe, Rübsam, Anne, Schlomberg, Juliane, and Pleyer, Uwe, editor

Published
2014
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38. Zur Versorgungssituation und konservativen Therapie des okulären vernarbenden Schleimhautpemphigoids in Deutschland.

Author

Yaïci, Rémi, Roth, Mathias, Juergens, Lukas, Nawaiseh, Sami Al, Burkhard, Dick, Besgen, Volker, Fuest, Matthias, Girbardt, Christian, Hampel, Ulrike, Heichel, Jens, Heiligenhaus, Arnd, Herwig-Carl, Martina C., Kakkassery, Vinodh, Kontopoulou, Kalliopi, Löffler, Karin U., Maier, Philip Christian, Nölle, Bernhard, Pach, Johanna, Paul, Sebastian, and Pleyer, Uwe

Published
2023
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42. A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis — A phase I clinical trial

Author

Thurau, Stephan, primary, Deuter, Christoph M. E., additional, Heiligenhaus, Arnd, additional, Pleyer, Uwe, additional, Van Calster, Joachim, additional, Barisani-Asenbauer, Talin, additional, Obermayr, Franz, additional, Sperl, Stefan, additional, Seda-Zehetner, Romana, additional, and Wildner, Gerhild, additional

Published
2022
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44. Verlauf der Uveitis bei Kindern mit juveniler idiopathischer Arthritis: Daten aus der Inzeptionskohorte ICON-JIA

Author

Klotsche, Jens, Sengler, Claudia, Foell, Dirk, Foeldvari, Ivan, Haas, Johannes-Peter, Horneff, Gerd, Dressler, Frank, Hospach, Anton, Kallinich, Tilmann, Liedmann, Ina, Mönkemöller, Kirsten, Niewerth, Martina, Weller-Heinemann, Frank, Windschall, Daniel, Heiligenhaus, Arnd, Minden, Kirsten, and Baquet-Walscheid, Karoline

Subjects
Medicine and health
Abstract

Einleitung: Die Uveitis ist eine extraartikuläre Manifestation der juvenilen idiopathischen Arthritis (JIA) und tritt bei bis zu 20% der Patienten auf. Eine unbehandelte und unkontrollierte Uveitis kann zu schwerwiegenden Komplikationen am Auge und sogar zur Erblindung führen. Das Ziel [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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45. Development and external validation of a model predicting new-onset chronic uveitis at different disease durations in juvenile idiopathic arthritis

Author

van Straalen, Joeri W., Kearsley-Fleet, Lianne, Klotsche, Jens, de Roock, Sytze, Minden, Kirsten, Heiligenhaus, Arnd, Hyrich, Kimme L., de Boer, Joke H., Lamot, Lovro, Olivieri, Alma N., Gallizzi, Romina, Smolewska, Elzbieta, Faugier, Enrique, Pastore, Serena, Hashkes, Philip J., Herrera, Cristina N., Emminger, Wolfgang, Consolini, Rita, Wulffraat, Nico M., Ruperto, Nicolino, Swart, Joost F., Cleary, G., Baildam, E., Wedderburn, L., Davidson, J., Chieng, A., McErlane, F., Foster, H., Ciurtin, C., Ioannou, Y., Thomson, W., Kallinich, Tilmann, Dressler, Frank, Deschner, Jasmin Kümmerle, Weller-Heinemann, Frank, Horneff, Gerd, Hospach, Anton, Mönkemöller, Kirsten, Haas, Johannes Peter, Windschall, Daniel, Foeldvari, Ivan, and Foell, Dirk

Subjects
Rheumatology, Immunology, Medizin, Uveitis, Juvenile Idiopathic Arthritis, JIA, Immunology and Allergy
Abstract

Objective: To develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical application. Methods: Data from the international Pharmachild registry were used to develop a multivariable Cox proportional hazards model. Predictors were selected by backward selection, and missing values were handled by multiple imputation. The model was subsequently validated and recalibrated in 2 inception cohorts: the UK Childhood Arthritis Prospective Study (CAPS) study and the German Inception Cohort of Newly diagnosed patients with juvenile idiopathic arthritis (ICON) study. Model performance was evaluated by calibration plots and C statistics for the 2-, 4-, and 7-year risk of uveitis. A diagram and digital risk calculator were created for use in clinical practice. Results: A total of 5, 393 patients were included for model development, and predictor variables were age at JIA onset (hazard ratio [HR] 0.83 [95% confidence interval (95% CI) 0.77-0.89]), ANA positivity (HR 1.59 [95% CI 1.06-2.38]), and International League of Associations for Rheumatology category of JIA (HR for oligoarthritis, psoriatic arthritis, and undifferentiated arthritis versus rheumatoid factor-negative polyarthritis 1.40 [95% CI 0.91- 2.16]). Performance of the recalibrated prediction model in the validation cohorts was acceptable ; calibration plots indicated good calibration and C statistics for the 7-year risk of uveitis (0.75 [95% CI 0.72-0.79] for the ICON cohort and 0.70 [95% CI 0.64-0.76] for the CAPS cohort). Conclusion: We present for the first time a validated prognostic tool for easily predicting chronic uveitis risk for individual JIA patients using common clinical parameters. This model could be used by clinicians to inform patients/parents and provide guidance in choice of uveitis screening frequency and arthritis drug therapy.

Published
2022

50. The majority of patients with newly diagnosed juvenile idiopathic arthritis achieve a health-related quality of life that is similar to that of healthy peers: results of the German multicenter inception cohort (ICON)

Author

Listing, Miriam, Mönkemöller, Kirsten, Liedmann, Ina, Niewerth, Martina, Sengler, Claudia, Listing, Joachim, Foell, Dirk, Heiligenhaus, Arnd, Klein, Ariane, Horneff, Gerd, Ganser, Gerd, Haas, Johannes-Peter, Klotsche, Jens, and Minden, Kirsten

Published
2018
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