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2. How Accurately Do Maize Crop Models Simulate the Interactions of Atmospheric CO2 Concentration Levels With Limited Water Supply on Water Use and Yield?

Author

Durand, Jean-Louis, Delusca, Kenel, Boote, Ken, Lizaso, Jon, Manderscheid, Remy, Weigel, Hans Johachim, Ruane, Alexander Clark, Rosenzweig, Cynthia E, Jones, Jim, Ahuja, Laj, Anapalli, Saseendran, Basso, Bruno, Baron, Christian, Bertuzzi, Patrick, Biernath, Christian, Deryng, Delphine, Ewert, Frank, Gaiser, Thomas, Gayler, Sebastian, Heilein, Florian, Kersebaum, Kurt Christian, Kim, Soo-Hyung, Muller, Christoph, Nendel, Claas, Olioso, Albert, Priesack, Eckart, Villegas, Julian Ramirez, Ripoche, Dominique, Rotter, Reimund P, Seidel, Sabine I, Srivastava, Amit, Tao, Fulu, Timlin, Dennis, Twine, Tracy, Wang, Enli, Webber, Heidi, and Zhao, Zhigan

Subjects
Earth Resources And Remote Sensing, Statistics And Probability, Meteorology And Climatology
Abstract

This study assesses the ability of 21 crop models to capture the impact of elevated CO2 concentration [CO2] on maize yield and water use as measured in a 2-year Free Air Carbon dioxide Enrichment experiment conducted at the Thunen Institute in Braunschweig, Germany (Manderscheid et al. 2014). Data for ambient [CO2] and irrigated treatments were provided to the 21 models for calibrating plant traits, including weather, soil and management data as well as yield, grain number, above ground biomass, leaf area index, nitrogen concentration in biomass and grain, water use and soil water content. Models differed in their representation of carbon assimilation and evapotranspiration processes. The models reproduced the absence of yield response to elevated [CO2] under well-watered conditions, as well as the impact of water deficit at ambient [CO2], with 50 percent of models within a range of plus/minus 1 Mg ha(exp. -1) around the mean. The bias of the median of the 21 models was less than 1 Mg ha(exp. -1). However under water deficit in one of the two years, the models captured only 30 percent of the exceptionally high [CO2] enhancement on yield observed. Furthermore the ensemble of models was unable to simulate the very low soil water content at anthesis and the increase of soil water and grain number brought about by the elevated [CO2] under dry conditions. Overall, we found models with explicit stomatal control on transpiration tended to perform better. Our results highlight the need for model improvement with respect to simulating transpirational water use and its impact on water status during the kernel-set phase.

Published
2017
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4. How accurately do crop models simulate the impact of CO2 atmospheric concentration on maize yield and water use?

Author

Durand, Jean-Louis, Delusca, Kénel, Boote, K., Lizaso, J., Manderscheid, R., Rosenzweig, C., Jones, J., Weigel, H.J., Ruane, A., Anapalli, S., Ahuja, L., Basso, B., Baron, C., Bertuzzi, Patrick, Ripoche, Dominique, Biernath, C., Priesak, E., Derynge, D., Ewert, F., Gaiser, T., Gayler, S., Heilein, F., Kersebaum, K.C., Kim, S.H., Müller, C., Nendel, C., Ramirez, J., Tao, F., Timlin, D., Waha, K., Twine, T., Wang, E., Webber, H., Zhao, Z., Rötter, R., Srivastava, A., Seidel, S., Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères (P3F), Institut National de la Recherche Agronomique (INRA), University of Florida [Gainesville] (UF), ETSIA, Johann Heinrich von Thünen Institut, NASA Goddard Institute for Space Studies (GISS), NASA Goddard Space Flight Center (GSFC), Colorado State University [Fort Collins] (CSU), Department of geological sciences, Michigan State University [East Lansing], Michigan State University System-Michigan State University System, Michigan State University System, Territoires, Environnement, Télédétection et Information Spatiale (UMR TETIS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Agroclim (AGROCLIM), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Tyndall Centre for Climate Change Research, University of East Anglia [Norwich] (UEA), Water and earth system science [Tübingen] (WESS), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Leibniz-Zentrum für Agrarlandschaftsforschung = Leibniz Centre for Agricultural Landscape Research (ZALF), School of Environmental and Forest Sciences, University of Washington [Seattle], Potsdam Institute for Climate Impact Research (PIK), School of Earth and Environment, University of Leeds, Institute of geographical sciences and natural resources research, Chinese Academy of Sciences [Changchun Branch] (CAS), United States Department of Agriculture (USDA), Centre for Environment Science and Climate Resilient Agriculture (CESCRA), Indian Agricultural Research Institute (IARI), Department of Soil, Water and Climate, University of Minnesota System, Land and Water, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Rheinische Friedrich-Wilhelms-Universität Bonn, China Agricultural University (CAU), Natural Resources Institute Finland (LUKE), Institute of Crop Science and Resource Conservation [Bonn], Technische Universität Dresden = Dresden University of Technology (TU Dresden), and ProdInra, Migration

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

5. How accurately do crop models simulate the impact of CO2 atmospheric concentration on maize yield and water use ? [O-2223-02]

Author

Durand, J.L., Delusca, Kenel, Boote, Kenneth J., Lizaso, Jon, Manderscheid, Remy, Rosenzweig, Cynthia, Jones, Jim, Weigel, Hans Johachim, Ruane, Alex C., Anapalli, Saseendran S., Ahuja, L., Basso, Bruno, Baron, Christian, Bertuzzi, Patrick, Ripoche, Dominique, Biernath, Christian, Priesak, E., Deryng, Delphine, Ewert, F., Gaiser, T., Gayler, S., Heilein, F., Kersebaum, Kurt Christian, Kim, S.H., Müller, C., Nendel, Claas, Ramirez, J., Tao, F., Timlin, D., Waha, K., Twine, Tracy E., Wang, E., Webber, Heidi, Zhao, Zhigan, Rötter, Reimund P., Srivastava, Amit, Seidel, S., Durand, J.L., Delusca, Kenel, Boote, Kenneth J., Lizaso, Jon, Manderscheid, Remy, Rosenzweig, Cynthia, Jones, Jim, Weigel, Hans Johachim, Ruane, Alex C., Anapalli, Saseendran S., Ahuja, L., Basso, Bruno, Baron, Christian, Bertuzzi, Patrick, Ripoche, Dominique, Biernath, Christian, Priesak, E., Deryng, Delphine, Ewert, F., Gaiser, T., Gayler, S., Heilein, F., Kersebaum, Kurt Christian, Kim, S.H., Müller, C., Nendel, Claas, Ramirez, J., Tao, F., Timlin, D., Waha, K., Twine, Tracy E., Wang, E., Webber, Heidi, Zhao, Zhigan, Rötter, Reimund P., Srivastava, Amit, and Seidel, S.

Abstract

Methods and Results Given the incertitudes on the climate change impacts on C4 crops, projections of regional maize production remain speculative. Assessment of the impacts of atmospheric CO2 concentration ([CO2]) on crop yield and resources uses using mechanistic models becomes increasingly important. Free Air [CO2] Enrichment (FACE) studies offer data to test and improve model quality. The objective of this work by the AgMIP Maize group was (i) to test multiple maize models for [CO2] responses against data gathered from a FACE study under two water regimes carried out in Germany during 2007 and 2008, and (ii) to pave the way to potential model modifications so as to improve their simulations of crop responses to [CO2]. The Experiment combined two [CO2] levels with two watering regimes. Yield, leaf area, soil water content and [CO2] levels were recorded both years, 2008 only exhibiting significant water deficit. After a preliminary calibration based on non limiting water conditions and under ambient [CO2] treatments of both years, a blind simulation was undertaken for the other treatments: High [CO2] (550 ppm) 2007 and 2008, both watering regimes, and DRY AMBIENT 2007 and 2008. Secondly, with full growth and yield data along with soil moisture data of all treatments, improvements of simulation results were attempted. Changes made to the models have been documented and submitted for further analysis. The results revealed: minimal [CO2] impacts with low variations among " uncalibrated " models except for the dry season of 2008 where the observed drought impact was simulated by the majority of models; most models caught but underestimated the CO2 impact on crop water status, leaf area, grain number and yield; the CO2 effect on transpiration was generally properly simulated, transpiration per leaf area decreasing but green leaf area duration increasing at 550 ppm [CO2]. As more data from FACE experiments become available, it will be highly desirable to replicate this e

Published
2015

7. Multizentrische prospektive kontrollierte Studie zur Therapie der chronisch myeloischen Leukämie. Vergleich von Busulfan, Hydroxyurea und Interferon alpha (Stand April 1990)

Author

M. Westerhausen, U. Queißer, G. Meuret, L. Schmid, J. Hohnloser, Wolfgang E. Berdel, Lothar Bergmann, F. Heiss, Helmut Löffler, W. Queißer, R. Burkhardt, P. v. Wussow, L. Kanz, Ruediger Hehlmann, P. D. Wickramanayake, WM Gallmeier, P. Meyer, B. Heinze, N. Schmitz, U.R. Kleeberg, F. Walther, C. Falge, Jörg Hasford, H. J. Kolb, H. Ansari, A. Heilein, H. Pralle, D.K. Hossfeld, A. Hochhaus, Hermann Heimpel, Axel Georgii, Hartmut Eimermacher, A. Tichelli, U. Essers, F.-J. Tigges, Volker Diehl, R. Zimmermann, M. Grießhammer, and A. Käbisch

Subjects
Cancer Research, Oncology, Hematology
Abstract

In einer multizentrischen Studie wird gepruft, ob der Einsatz von Hydroxyurea oder von Interferon alpha anstatt von Bulsulfan die Dauer der chronischen Phase bei Patienten mit Philadelphia-Chromo-som-positiver CML verlangert. Zusatzliche Ziele sind die Prufung, ob sich der Typ der Krankheitsevolution und die terminalen Phasen bei den verschiedenen Therapiegruppen unterscheiden, sowie die pro-, spektive Erkennung von Prognosekriterien fur die Dauer der chronischen Phase. Bis zum 5.9.1990 waren 593 CML-Patienten randomisiert, 221 fur Busulfan, 228 fur Hydroxyurea und 144 fur Interferon alpha. Das Durchschnittsalter aller Patienten liegt bei etwa 51 Jahren. Bis zum Stichtag am 30.4.1990 hatten 106 Patienten das Ende der chronischen Phase erreicht, 126 waren verstorben. Die mediane Uberlebenszeit der Philadelphia-positiven Patienten betrug 3,95 Jahre, die aller Patienten 3,75 Jahre. Die mittlere Beobachtungszeit betrug 1,34 (1,60) Jahre. Erwartungsgemas besteht bisher noch kein signifikanter Unterschied zwischen den drei Studienarmen, wenn auch im Hydroxyurea-Arm weniger Nebenwirkungen beobachtet wurden.

Published
1991

8. Interferon-α in the Treatment of CML: Comparison of Busulfan versus Hydroxyurea versus Interferon-α

Author

R. Hehlmann, L. Bergmann, H. Heimpel, H. J. Kolb, B. Heinze, A. Hochhaus, M. Griesshammer, H. Pralle, W. Queisser, U. Essers, C. Falge, U. Queisser, P. Meyer, N. Schmitz, K. Verpoort, F. Walther, M. Westerhausen, U. R. Kleeberg, A. Heilein, A. Käbisch, C. Nerl, C. Barz, R. Zimmermann, G. Meuret, A. Tichelli, W. E. Berdel, F. -J. Tigges, H. Eimermacher, L. Schmid, R. Zankovich, J. Thiele, H. Löffler, P. v. Wussow, T. Buhr, A. Georgii, D. K. Hossfeld, H. Ansari, J. Hasford, and null the German CML Study Group

Subjects
business.industry, Interferon α, Medicine, Pharmacology, business, Busulfan, medicine.drug
Published
1994

9. The German CML study, comparison of busulfan vs. hydroxyurea vs. interferon alpha and establishment of prognostic score 1

Author

R. Hehlmann, H. Heimpel, H. J. Kolb, B. Heinze, A. Hochhaus, M. Griesshammer, H. Pralle, W. P. D. Queisser, U. Essers, C. Falge, L. Bergmann, U. Queisser, P. Meyer, N. Schmitz, P. D. Wickramanayake, F. Walther, M. Westerhausen, U. R. Kleeberg, A. Heilein, A. Käbisch, F. Heiss, R. Zimmermann, G. Meuret, A. Tichelli, W. E. Berdel, F.-J. Tigges, H. Eimermacher, L. Schmid, R. Zankovich, J. Thiele, H. Löffler, P. v. Wussow, T. Buhr, A. Georgii, D. K. Hossfeld, H. Ansari, J. Hasford, and null German CML Study Group

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Alpha interferon, Gastroenterology, Organomegaly, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Prognostic score, Internal medicine, Germany, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Medicine, Humans, Hydroxyurea, Immunologic Factors, Life Tables, Prospective Studies, Busulfan, Proportional Hazards Models, business.industry, Germany, West, Interferon-alpha, Hematology, Middle Aged, Prognosis, Survival Analysis, Surgery, Karnofsky index, Circulating Blasts, Treatment Outcome, Oncology, Leukemia, Myeloid, Chronic-Phase, Female, medicine.symptom, business, Median survival, Switzerland, medicine.drug
Abstract

From July 1983 to January 1991 a total of 622 patients were randomized (585 eligible) to compare the effects of hydroxyurea, interferon alpha (IFN), and busulfan on the duration of chronic phase, and survival. Further goals included the determination of prognostic parameters. 598 CML patients were documented and 575 evaluable. The Ph-status was known for 547 patients. 89.4% of the patients were Ph-positive (+). 11% had additional chromosome aberrations. The median survival of Ph+ patients by now is 4.2 years, that of Ph-patients 1.4 years. Ph-negative patients are older, tend to have lower cell counts and, as a group are more ill at diagnosis. A survival difference of about one year is expected between busulfan and hydroxyurea treated patients. Prospectively evaluated age, organomegaly related symptoms, Karnofsky index, extramedullary manifestations, number of erythroblasts and percent of circulating blasts proved to be of prognostic significance. A prognostic score (score 1) was determined which was superior to Sokal's score in the study population. 164 patients were randomized to receive IFN. In 54 patients (33%) IFN had to be terminated because of adverse effects, therapy resistance or other reasons. Clinically relevant neutralizing antibodies were detected in 9 cases. Most frequent adverse events were flu-like symptoms in 74%, gastrointestinal symptoms in 52%, and neurologic-psychiatric symptoms in 30% of patients. Reduction of the Ph-chromosome was observed in 13% of evaluable patients (10 of 75). In 4 patients complete cytogenetic remissions were observed, in three of these ongoing. Cytogenetic responders have a survival advantage. Interferon treated Philadelphia-negative CML patients have no survival disadvantage. The study is expected to allow statements as to the advantages or disadvantages of the use of busulfan, hydroxyurea and IFN in the treatment of CML as well as to the reliability of prognostic markers.

Published
1993

10. Multizentrische prospektive kontrollierte Studie zur Therapie der chronisch myeloischen Leukämie. Vergleich von Busulfan, Hydroxyurea und Interferon alpha (Stand April 1990)

Author

Hehlmann, R., primary, Heimpel, H., additional, Heinze, B., additional, Georgii, A., additional, Kolb, H.J., additional, Hossfeld, D.K., additional, Wussow, P.v., additional, Hochhaus, A., additional, Grießhammer, M., additional, Diehl, V., additional, Wickramanayake, P.D., additional, Gallmeier, W., additional, Falge, C., additional, Essers, U., additional, Bergmann, L., additional, Meyer, P., additional, Walther, F., additional, Kanz, L., additional, Queißer, U., additional, Hohnloser, J., additional, Westerhausen, M., additional, Kleeberg, U.R., additional, Heilein, A., additional, Käbisch, A., additional, Heiss, F., additional, Zimmermann, R., additional, Meuret, G., additional, Tichelli, A., additional, Berdel, W.E., additional, Schmitz, N., additional, Tigges, F.-J., additional, Eimermacher, H., additional, Schmid, L., additional, Löffler, H., additional, Pralle, H., additional, Queißer, W., additional, Burkhardt, R., additional, Ansari, H., additional, and Hasford, J., additional

Published
1991
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11. Accumulation of the mithochondrial form of the sulphydryl oxidase Erv1p/Alrp during the early stages of spermatogenesis.

Author

Klissenbauer, Monika, Winters, Silke, Heilein, Uwe A.O., and Lisowsky, Thomas

Subjects
MITOCHONDRIA, OXIDASES
Abstract

Investigates the accumulation of the mitochondrial form of the sulphydryl oxidase Erv1p/a1rp during the early stages of spermatogenesis. Forms of a1rp in protein extracts from different tissues and organs; Protein analysis of mouse testis; Serum albumin.

Published
2002

13. Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group

Author

Hehlmann, R, Heimpel, H, Hasford, J, Kolb, HJ, Pralle, H, Hossfeld, DK, Queiβer, W, Löffler, H, Heinze, B, Georgii, A, Wussow, P.v., Bartram, C., Grieβhammer, M., Bergmann, L., Essers, U., Falge, C., Hochhaus, A., Queiβer, U., Sick, C., Meyer, P., Schmitz, N., Verpoort, K., Eimermacher, H., Walther, F., Westerhausen, M., Kleeberg, U.R., Heilein, A., Käbisch, A., Barz, C., Zimmermann, R., Meuret, G., Tichelli, A., Berdel, W.E., Kanz, L., Anger, B., Tigges, F.J., Schmid, L., Brockhaus, W., Zankovich, R., Schlafer, U., Weiβenfels, I., Mainzer, K., Tobler, A., Perker, M., Hohnloser, J., Messener, D., Thiele, J., Buhr, T., and Ansah, H.

Abstract

In a randomized multicenter study the influence of hydroxyurea versus busulfan on the duration of the chronic phase and on survival of chronic myelogenous leukemia (CML) was determined. In addition cross resistance and adverse reactions of the drugs were analyzed. From July 1983 to January 1991, 441 CML patients were randomized to receive hydroxyurea or busulfan. Of these, 90.7% were Philadelphia positive; 25.7% were low, 38.2% intermediate, and 36.2% high risk patients according to Sokal's score. The median survival of the busulfan treated Philadelphia-positive patients is 45.4 months and of the hydroxyurea group 58.2 months (P = .008). The survival advantage for the hydroxyurea treated patients is recognized in all risk groups. Sixty four patients reached therapy resistance before blast crisis and were crossed over to the alternative drug. The 23 patients with primary hydroxyurea had a median survival of 5.6 years, the 41 patients with primary busulfan therapy a median survival of 2.7 years (P = .02). Adverse reactions were less frequent with hydroxyurea with no severe adverse effects (lung fibrosis, long lasting bone marrow aplasia). The analysis of white blood cell counts in the course of treatment showed lower counts in the hydroxyurea patients. We conclude that hydroxyurea is superior to busulfan in therapy of CML in chronic phase and should be used as first line therapy. Busulfan may have a role as secondary therapy after hydroxyurea resistance or intolerance.

Published
1993
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