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2. Collagens as New Players in Nervous System Diseases

Author

Heikkinen, Anne, Fox, Michael A., Pihlajaniemi, Taina, Karamanos, Nikos K., Series Editor, Kletsas, Dimitris, Editorial Board Member, Oh, Eok-Soo, Editorial Board Member, Passi, Alberto, Editorial Board Member, Pihlajaniemi, Taina, Editorial Board Member, Ricard-Blum, Sylvie, Editorial Board Member, Sagi, Irit, Editorial Board Member, Savani, Rashmin, Editorial Board Member, Watanabe, Hideto, Editorial Board Member, and Ruggiero, Florence, editor

Published
2021
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4. Expression of Collagen XIII in Tissues of the Thyroid and Orbit With Relevance to Thyroid-Associated Ophthalmopathy

Author

Norman, Oula, primary, Vornanen, Tuuli, additional, Franssila, Hanna, additional, Liinamaa, Johanna, additional, Karvonen, Elina, additional, Kotkavaara, Tommi, additional, Pohjanen, Vesa-Matti, additional, Ylikärppä, Ritva, additional, Pihlajaniemi, Taina, additional, Hurskainen, Merja, additional, and Heikkinen, Anne, additional

Published
2024
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6. Integrin α11β1 is a receptor for collagen XIII

Author

Koivunen, Jarkko, Tu, Hongmin, Kemppainen, Antti, Anbazhagan, Padmanabhan, Finnilä, Mikko A., Saarakkala, Simo, Käpylä, Jarmo, Lu, Ning, Heikkinen, Anne, Juffer, André H., Heino, Jyrki, Gullberg, Donald, and Pihlajaniemi, Taina

Published
2021
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10. Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease

Author

Khoshneviszadeh, Mahsima, primary, Jandke, Solveig, additional, Morton, Lorena, additional, Kaushik, Rahul, additional, Arndt, Philipp, additional, Norman, Oula, additional, Jukkola, Jari, additional, Dunay, Ildiko Rita, additional, Seidenbecher, Constanze, additional, Heikkinen, Anne, additional, Schreiber, Stefanie, additional, and Dityatev, Alexander, additional

Published
2023
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11. Supplementary Materials and Methods from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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12. Supplementary Movie 1 from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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13. Supplementary Tables from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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14. Supplementary Figures from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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15. SupplementaryMovieLegends.pdf from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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16. Supplementary Movie 2 from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., primary, Pietilä, Riikka, primary, Kaakinen, Mika, primary, Ronkainen, Veli-Pekka, primary, Tu, Hongmin, primary, Heikkinen, Anne, primary, Devarajan, Raman, primary, Miinalainen, Ilkka, primary, Laitakari, Anna, primary, Ansarizadeh, Mohammadhassan, primary, Zhang, Qin, primary, Wei, Gong-Hong, primary, Ruddock, Lloyd, primary, Pihlajaniemi, Taina, primary, Elamaa, Harri, primary, and Eklund, Lauri, primary

Published
2023
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22. EOSC-Life EOSC FAIR services deployment for open calls

Author

Parkinson, Helen, Gribbon, Philip, Sarkans, Ugis, Witt, Gesa, Zaliani, Andrea, Kohler, Manfred, Swedlow, Jason, Burel, Jean-Marie, Swertz, Morris, van Enckevort, Esther, Holub, Petr, Massimi, Marzia, Matteoni, Rafaele, Maier, Holger, Hinttala, Reetta, Heikkinen, Anne, Gormanns, Philipp, Vasseur, Laurent, Leblanc, Sophie, Herault, Yann, Kontoyiannis, Dimitris, Chandras, Christina, Panou, Dimitra, López Coronado, José Miguel, Aznar Novella, Rosa, Robert, Vincent, Hadj Amor, Ammar Ben, Casaregola, Serge, Legras, Jean-Luc, Mistou, Michel-Yves, Romano, Paolo, Perseil, Isabelle, David, Romain, Pieruschka, Roland, Exter, Katrina, Portier, Marc, Decruw, Cedric, Canham, Steve, Ohmann, Christian, Goryanin, Sergey, Del Cano, Laura, Fratelli, Maddalena, Goble, Carole, Owen, Stuart, Soiland- Reyes, Stian, Juty, Nick, Harmse, Henriette, Longo, Dario, Sansone, Susanna, Lister, Allyson L., McQuilton, Peter, Tursthon, Milo, Granell, Ramon, Mirian, Hossein, Roos, Marco, and Bonino, Luiz

Subjects
FAIR data, Life science research infrastructures, FAIR services
Abstract

This deliverable summarises the work of WP1 to deliver Findable, Accessible, Interoperable and Re-usable (FAIR) services in the context of EOSC-Life’s funding calls, using these to improve FAIR services, service uptake and to inform sustainable development and future use. We describe service delivery and development around the FAIR principles and present the funded projects which have driven our implementation of FAIR Services. We address sustainability and describe the processes used to engage the EOSC-Life funded projects, as well as future work.

Published
2022
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23. EOSC-Life -D1.3 EOSC-Life EOSC FAIR services deployment for open calls

Author

Parkinson, Helen, Gribbon, Philip, Sarkans, Ugis, Witt, Gesa, Zaliani, Andrea, Kohler, Manfred, Swedlow, Jason, Burel, Jean-Marie, Swertz, Morris, van Enckevort, Esther, Holub, Petr, Massimi, Marzia, Matteoni, Rafaele, Maier, Holger, Hinttala, Reetta, Heikkinen, Anne, Gormanns, Philipp, Vasseur, Laurent, Leblanc, Sophie, Herault, Yann, Kontoyiannis, Dimitris, Chandras, Christina, Panou, Dimitra, López-Coronado, José-Miguel, Aznar-Novella, Rosa, Robert, Vincent, Hadj-Amor, Ammar-Ben, Casaregola, Serge, Legras, Jean-Luc, Mistou, Michel-Yves, Romano, Paolo, Perseil, Isabelle, David, Romain, Pieruschka, Roland, Exter, Katrina, Portier, Marc, Decruw, Cedric, Canham, Steve, Ohmann, Christian, Goryanin, Sergey, Del-Cano, Laura, Fratelli, Maddalena, Goble, Carole, Owen, Stuart, Soiland-Reyes, Stian, Juty, Nick, Harmse, Henriette, Longo, Dario, Sansone, Susanna, Lister, Allyson-L., Mcquilton, Peter, Tursthon, Milo, Granell, Ramon, Mirian, Hossein, Roos, Marco, Bonino, Luiz, European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), European Molecular Biology Laboratory [Hinxton], Centre for Gene Regulation and Expression, School of Life Sciences Dundee, University of Dundee, Division of Computational Biology, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University Medical Center Groningen [Groningen] (UMCG), European research infrastructure for biobanking (BBMRI-ERIC), Consiglio Nazionale delle Ricerche [Bologna] (CNR), University of South Australia [Adelaide], MRC Harwell Institute [UK], INFRAFRONTIER GmbH [Neuherberg], Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), IRCCS Ospedale Policlinico San Martino [Genoa, Italy], INSERM-TRANSFERT [Paris] (IT), Institut National de la Santé et de la Recherche Médicale (INSERM), European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), IBG-2: Plant Sciences, Flanders Marine Institute (VLIZ), European Clinical Research Infrastructures Network [Dusseldorf] (ECRIN), IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri' [Milan, Italy], The University of Manchester, University of Oxford, Fraunhofer-Institut für Offene Kommunikationssysteme (FOKUS Fraunhofer), EMBL, CSIC, VU, BBMRI, KNAW, UVEG, USMI, IMG, UNIMAN, LUMC, EATRIS, UNIMIB, EBI, ECRIN, EMBRC, EMPHASIS (FZJ), ERINHA, INFRAFRONTIER, INRAE, UNIVDUN, HMGU, CERBM, BSCRC, UOULU, CRRMMP, and European Project: 824087,EOSC-Life

Subjects
Life science, FAIR data, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], research infrastructures, FAIR services
Abstract

This deliverable summarises the work of WP1 to deliver Findable, Accessible, Interoperable and Re-usable (FAIR) services in the context of EOSC-Life’s funding calls, using these to improve FAIR services, service uptake and to inform sustainable development and future use. We describe service delivery and development around the FAIR principles and present the funded projects which have driven our implementation of FAIR Services. We address sustainability and describe the processes used to engage the EOSC-Life funded projects, as well as future work.

Published
2022

24. Modeling Rare Human Disorders in Mice : The Finnish Disease Heritage

Author

Zárybnický, Tomáš, Heikkinen, Anne, Kangas, Salla M., Karikoski, Marika, Martinez-Nieto, Guillermo Antonio, Salo, Miia H., Uusimaa, Johanna, Vuolteenaho, Reetta, Hinttala, Reetta, Sipilä, Petra, Kuure, Satu, Helsinki Institute of Life Science HiLIFE, STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine, Kidney development, and Biosciences

Subjects
LYSOSOMAL STORAGE DISORDER, rare diseases, Finnish disease heritage, STEM-CELL TRANSPLANTATION, MOUSE MODEL, monogenic diseases, CRISPR/Cas9, NEURONAL CEROID-LIPOFUSCINOSIS, DEGENERATION MND MUTANT, MITOCHONDRIAL TRIFUNCTIONAL PROTEIN, 3-HYDROXYACYL-COA DEHYDROGENASE-DEFICIENCY, CARTILAGE-HAIR HYPOPLASIA, HYDROLETHALUS SYNDROME, 1182 Biochemistry, cell and molecular biology, mouse models, genome engineering, ACUTE FATTY LIVER
Abstract

The modification of genes in animal models has evidently and comprehensively improved our knowledge on proteins and signaling pathways in human physiology and pathology. In this review, we discuss almost 40 monogenic rare diseases that are enriched in the Finnish population and defined as the Finnish disease heritage (FDH). We will highlight how gene-modified mouse models have greatly facilitated the understanding of the pathological manifestations of these diseases and how some of the diseases still lack proper models. We urge the establishment of subsequent international consortiums to cooperatively plan and carry out future human disease modeling strategies. Detailed information on disease mechanisms brings along broader understanding of the molecular pathways they act along both parallel and transverse to the proteins affected in rare diseases, therefore also aiding understanding of common disease pathologies.

Published
2021

25. Modeling Rare Human Disorders in Mice: The Finnish Disease Heritage

Author

Zárybnický, Tomáš, primary, Heikkinen, Anne, additional, Kangas, Salla M., additional, Karikoski, Marika, additional, Martínez-Nieto, Guillermo Antonio, additional, Salo, Miia H., additional, Uusimaa, Johanna, additional, Vuolteenaho, Reetta, additional, Hinttala, Reetta, additional, Sipilä, Petra, additional, and Kuure, Satu, additional

Published
2021
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26. Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model

Author

Martínez-Nieto, Guillermo, primary, Heljasvaara, Ritva, additional, Heikkinen, Anne, additional, Kaski, Hanne-Kaisa, additional, Devarajan, Raman, additional, Rinne, Otto, additional, Henriksson, Charlotta, additional, Thomson, Emmi, additional, von Hertzen, Camilla, additional, Miinalainen, Ilkka, additional, Ruotsalainen, Heli, additional, Pihlajaniemi, Taina, additional, and Karppinen, Sanna-Maria, additional

Published
2021
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27. EOSC-Life EOSC repository deployment for project demonstrators

Author

Parkinson, Helen, Gribbon, Philip, Sarkans, Ugis, Witt, Gesa, Zaliani, Andrea, Kohler, Manfred, Swedlow, Jason, Burel, Jean-Marie, Swertz, Morris, van Enckevort, Esther, Holub, Petr, Massimi, Marzia, Matteonie, Rafaele, Maier, Holger, Hinttala, Reetta, Heikkinen, Anne, Gormanns, Philipp, del Cano, Laura, Vasseur, Laurent, Leblanc, Sophie, Herault, Yann, Kontoyiannis, Dimitris, Chandras, Christina, Panou, Dimitra, López Coronado, José Miguel, Aznar Novella, Rosa, Robert, Vincent, Hadj Amor, Ammar Ben, Casaregola, Serge, Legras, Jean-Luc, Mistou, Michel-Yves, Romano, Paolo, Perseil, Isabelle, David, Romain, Pieruschka, Roland, Exter, Katrina, Portier, Marc, Decruw, Cedric, Canham, Steve, Ohmann, Christian, Goryanin, Sergey, Del Cano, Laura, Fratelli, Maddalena, Goble, Carole, Owen, Stuart, Soiland-Reyes, Stian, Juty, Nick, Sansone, Susanna, McQuilton, Peter, Roos, Marco, and Bonino, Luiz

Subjects
Life science data registries, FAIR life science data, Cloud repositories, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Cross registry interoperability
Abstract

This deliverable addresses WP1’s objectives related to publication of data and data resources in cloud repositories by making available resources in EOSC-Life’s registries; the implementation of FAIR services and standards, by development of FAIR registries in collaboration with WP6; and evolution of repository infrastructure by making available registry entries deriving from WP3 demonstrators. Use cases for EOSC-Life registries have been defined for general and clinical research data use and the ‘EOSC-Life’ collection in FAIRsharing has been populated and released comprising more than 100 data resources and standards. A clinical MetaData Repository has also been developed to address challenges of clinical data sharing in Europe. We have engaged with EOSC, sister projects such as FAIRsFAIR and ENVRI to consider the features of registries, cross registry interoperability and use cases which link EOSC projects. We will continue to update the registries as the project progresses and as new dataset and resources are made available and will engage with pan-EOSC registry planning based on our work to date.

Published
2021
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28. EOSC-Life D1.2 EOSC repository deployment for project demonstrators

Author

Parkinson, Helen, Gribbon, Philip, Sarkans, Ugis, Witt, Gesa, Zaliani, Andrea, Kohler, Manfred, Swedlow, Jason, Burel, Jean-Marie, Swertz, Morris, Van-Enckevort, Esther, Holub, Petr, Massimi, Marzia, Matteonie, Rafaele, Maier, Holger, Hinttala, Reetta, Heikkinen, Anne, Gormanns, Philipp, Del-Cano, Laura, Vasseur, Laurent, Leblanc, Sophie, Herault, Yann, Kontoyiannis, Dimitris, Chandras, Christina, Panou, Dimitra, López-Coronado, José-Miguel, Aznar-Novella, Rosa, Robert, Vincent, Hadj-Amor, Ammar-Ben, Casaregola, Serge, Legras, Jean-Luc, Mistou, Michel-Yves, Romano, Paolo, Perseil, Isabelle, David, Romain, Pieruschka, Roland, Exter, Katrina, Portier, Marc, Decruw, Cedric, Canham, Steve, Ohmann, Christian, Goryanin, Sergey, del Cano, Laura, Fratelli, Maddalena, Goble, Carole, Owen, Stuart, Soiland-Reyes, Stian, Juty, Nick, Sansone, Susanna, Mcquilton, Peter, Roos, Marco, Bonino, Luiz, European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Fraunhofer Institute for Systems and Innovation Research (Fraunhofer ISI ), Fraunhofer (Fraunhofer-Gesellschaft), Centre for Gene Regulation and Expression, School of Life Sciences Dundee, University of Dundee, Division of Computational Biology, University Medical Center Groningen [Groningen] (UMCG), European research infrastructure for biobanking (BBMRI-ERIC), Consiglio Nazionale delle Ricerche - CNR [Pisa, Italia], Istituto di Fisiologia Clinica - IFC [Pisa, Italia], Consiglio Nazionale delle Ricerche [Milano] (CNR), MRC Harwell Institute [UK], PHENOMIN, GIE CERBM, Institute of Genetics and Molecular and Cellular Biology (IGBMC), INSERM-U964, Strasbourg University, Illkirch, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), INFRAFRONTIER GmbH [Neuherberg], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Departamento de Fisica Teorica and IFIC (CSIC- UVEG), Universitat de València (UV), Royal Netherlands Academy of Arts and Sciences (KNAW), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), INSEAN - CNR, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut National de la Santé et de la Recherche Médicale (INSERM), European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), IBG-2: Plant Sciences, Flanders Marine Institute (VLIZ), European Clinical Research Infrastructures Network [Dusseldorf] (ECRIN), Centro de Investigaciones Biológicas (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Istituto di Ricerche Farmacologiche Mario Negri (IRFMN), University of Manchester [Manchester], Oxford e-Research Centre [Oxford], University of Oxford, Center for Infectious Diseases [LUMC, Leiden] (CID), Leiden University Medical Center (LUMC), Universiteit Leiden-Universiteit Leiden, Fraunhofer-Institut für Offene Kommunikationssysteme (FOKUS Fraunhofer), EMBL, VU, KNAW, BBMRI, UVEG, USMI, IMG, CNRI, UNIMAN, LUMC, EATRIS, INRAE, ECRIN, EMBRC, EMPHASIS (FZJ), ERINHA, INFRAFRONTIER, UNIMIB, UNIVDUN, HMGU, CERBM, BSCRC, UOULU, CIRMMP, CSIC, and European Project: 824087,EOSC-Life

Subjects
data, Life science data, life science, registries, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Cloud, repositories, Cross registry interoperability, FAIR
Abstract

This deliverable addresses WP1’s objectives related to publication of data and data resources in cloud repositories by making available resources in EOSC-Life’s registries; the implementation of FAIR services and standards, by development of FAIR registries in collaboration with WP6; and evolution of repository infrastructure by making available registry entries deriving from WP3 demonstrators. Use cases for EOSC-Life registries have been defined for general and clinical research data use and the ‘EOSC-Life’ collection in FAIRsharing has been populated and released comprising more than 100 data resources and standards. A clinical MetaData Repository has also been developed to address challenges of clinical data sharing in Europe. We have engaged with EOSC, sister projects such as FAIRsFAIR and ENVRI to consider the features of registries, cross registry interoperability and use cases which link EOSC projects. We will continue to update the registries as the project progresses and as new dataset and resources are made available and will engage with pan-EOSC registry planning based on our work to date.

Published
2021

30. The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Author

Kapiainen, Emmi, primary, Kihlström, Minna K., additional, Pietilä, Riikka, additional, Kaakinen, Mika, additional, Ronkainen, Veli-Pekka, additional, Tu, Hongmin, additional, Heikkinen, Anne, additional, Devarajan, Raman, additional, Miinalainen, Ilkka, additional, Laitakari, Anna, additional, Ansarizadeh, Mohammadhassan, additional, Zhang, Qin, additional, Wei, Gong-Hong, additional, Ruddock, Lloyd, additional, Pihlajaniemi, Taina, additional, Elamaa, Harri, additional, and Eklund, Lauri, additional

Published
2021
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31. Integrin α11β1 is a receptor for collagen XIII

Author

Koivunen, Jarkko, primary, Tu, Hongmin, additional, Kemppainen, Antti, additional, Anbazhagan, Padmanabhan, additional, Finnilä, Mikko A., additional, Saarakkala, Simo, additional, Käpylä, Jarmo, additional, Lu, Ning, additional, Heikkinen, Anne, additional, Juffer, André H., additional, Heino, Jyrki, additional, Gullberg, Donald, additional, and Pihlajaniemi, Taina, additional

Published
2020
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37. Correct expression and localization of collagen XIII are crucial for the normal formation and function of the neuromuscular system

Author

Härönen, Heli, primary, Zainul, Zarin, additional, Naumenko, Nikolay, additional, Sormunen, Raija, additional, Miinalainen, Ilkka, additional, Shakirzyanova, Anastasia, additional, Santoleri, Sabrina, additional, Kemppainen, Antti V., additional, Giniatullin, Rashid, additional, Pihlajaniemi, Taina, additional, and Heikkinen, Anne, additional

Published
2019
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40. Puheenjohtajana sosiaali- ja terveysjärjestössä : intressinä aatteen palo, asiat vai 'minä' -projektit?

Author

Heikkinen, Anne

Subjects
intressiristiriidat, arvorationaalinen toiminta, intressi, intressit, puheenjohtajat, sosiaali- ja terveysjärjestöt, päämäärärationaalinen toiminta, arvot, kansalaisjärjestöt
Abstract

TIIVISTELMÄ PUHEENJOHTAJANA SOSIAALI- JA TERVEYSJÄRJESTÖSSÄ Intressinä aatteen palo, asiat vai ”minä” -projektit? Anne Heikkinen Sosiologia/Kansalaisyhteiskunnan asiantuntijuuden maisteriohjelma Pro gradu-tutkielma Yhteiskuntatieteiden ja filosofian laitos Jyväskylän yliopisto Ohjaaja: Petri Ruuskanen Kevät 2016 94 sivua + 6 liitettä Tutkimuksen tarkoituksena oli selvittää mitkä intressit ohjaavat sosiaali- ja terveysjärjestöjen puheenjohtajien toimintaa ja valintoja. Seuraaviin tutkimuskysymyksiin haettiin vastauksia: 1. Onko toiminnan taustalla edelleen aatteen palo vai ohjaako osallistumista henkilökohtaiset intressit ns. ”minä” -projektit? 2. Ovatko puheenjohtajien intressit arvo- vai päämäärärationaalisia vai yhdistelmä molemmista? 3. Mikä osuus on pierre-bourdieulaisella ”todennäköisellä kausaalisuudella” ja ”riittävän järjen periaatteella”? Tutkimukseen haastateltiin 19:sta sosiaali- ja terveysjärjestön puheenjohtajaa. Aineisto muodostui rikkaaksi, sillä otokseen valikoituneilla puheenjohtajilla oli pitkä kokemus järjestötyöstä ja/tai yhteiskunnallisesta vaikuttamisesta, joten he pystyivät tuomaan keskusteluun koko sen sosiaalisen kentän, jossa sosiaali- ja terveysjärjestöjen puheenjohtajat operoivat. Aineisto analysoitiin induktiivisesti, ja analyysimenetelmäksi valittiin sisällön erittely. Aineistolle tehtiin tutkimuskysymysten mukaisia kysymyksiä. Pelkistämällä, tiivistämällä ja kategorisoimalla autenttisia ilmaisuja puheenjohtajien toiminnan intresseihin löydettiin merkityssisällöt. Aineisto tuottama tieto järjestökentän konfliktiherkkyydestä on myös raportoitu. Tulosten mukaan sosiaali- ja terveysjärjestöjen puheenjohtajien toiminnan taustalla vaikuttaa edelleen aatteen palo, yleishumanismi. Puheenjohtajien sitoutuneisuus luottamustoimen hoitamiseen oli vahvaa, eikä heidän toimintaansa ohjannut omaa statusasemaa pönkittävä ”mi-nä”-orientaatio (arvorationaalinen toiminta). Tehtävässään he toimivat tavoitteellisesti, ja nimesivät itsensä lähinnä asiajohtajaksi (päämäärärationaalinen toiminta). Tutkimus vahvisti aikaisempia tuloksia yhdistyslaitoksen konfliktiherkkyydestä. Yhdistyslaitos on jo rakenteeltaan ”nippu intressejä”, ja siten herkkä konflikteille, joita tämän tutkimuksen mukaan esiintyi organisaation kaikilla tasoilla. Tutkimus tuotti tietoa puheenjohtajan keskeisestä asemasta intressiristiriitojen hoidossa, ja laaja-alaisesta osaamispääomasta, jota luottamustoimen hoitaminen tänä päivänä edellyttää. Puheenjohtajan tulee hallita järjestö- ja työelämälainsäädän-tö, ja rehellisyyttä ja emotionaalista intelligenssiä puheenjohtajilta edellytetään silloin, kun päätöksiä on pakko tehdä ”riittävän järjen periaatteella” inhimillistä ihmisistä koostuvalla sosiaalisella kentällä, jossa ihmiset eivät aina toimi puhtaan rationaalisesti. Tulosten mukaan puheenjohtajan omalla työelämätaustalla on positiivista merkitystä luottamustehtävän hoidossa. Tutkimus toi esille myös puheenjohtajien suuren työmäärän ja vaaran uupua.

Published
2016

42. Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse

Author

Härönen, Heli, primary, Zainul, Zarin, additional, Tu, Hongmin, additional, Naumenko, Nikolay, additional, Sormunen, Raija, additional, Miinalainen, Ilkka, additional, Shakirzyanova, Anastasia, additional, Oikarainen, Tuomo, additional, Abdullin, Azat, additional, Martin, Paula, additional, Santoleri, Sabrina, additional, Koistinaho, Jari, additional, Silman, Israel, additional, Giniatullin, Rashid, additional, Fox, Michael A., additional, Heikkinen, Anne, additional, and Pihlajaniemi, Taina, additional

Published
2017
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