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1,003 results on '"Heike, Toshio"'

2. How to Prepare Mental Health Resources for Future Pandemics: A Mixed Method Study in a Pediatric Oncology Ward During the COVID-19 Outbreak

Author

Kobayashi, Kenichiro, Inoue, Michiko, Shibata, Mariko, Ochi, Koichi, Maihara, Toshiro, Usami, Ikuya, Mino, Koichi, and Heike, Toshio

Subjects
Pediatric nursing -- Psychological aspects, Epidemics -- Psychological aspects -- Japan, Hospital wards -- Human resource management, Psychiatric services -- Planning -- Usage, Cancer in children -- Care and treatment, Medical personnel -- Health aspects -- Psychological aspects, Company business planning, Company personnel management, Health
Abstract

Purpose: Psychological distress in health care workers (HCWs) caring for pediatric patients with cancer was evaluated during the COVID-19 outbreak to inform future perspectives of mental health resources for frontline providers. Design and Methods: A qualitative and quantitative mixed method study was conducted using a semi-structured interview to understand the occupational distress and dilemma of HCWs employed in a pediatric cancer ward. A follow-up survey was used to further validate results. Results: Pediatric oncology HCWs were highly willing to cope with difficulties during the earliest phase of the pandemic. Still, nursing staff perceived more intense psychological distress in comparison with physicians and were challenged to maintain interpersonal communication. Nurses also felt incompetent to prioritize physical distancing. Their negative emotions were further exacerbated with limited help-seeking behavior and professional self-stigma. Conclusions: To foster the mental health resilience and a self-care attitude in a vulnerable subgroup (nursing staff with less than 5 years of professional experience), it is important to provide a broad range of mental health resources, including institutional support and/or digital health tools (e.g., web-based decision aids, online cognitive behavioral therapy, and telemedicine) aimed to meet their diverse psychosocial needs. A series of individualized approaches might be helpful to promote frontline providers' stress-coping strategies as comprehensible, manageable, and meaningful. Key Words: COVID-19, mental health resources, help-seeking behavior, institutional support, digital health tools., Since the beginning of the 21st century, many highly pathogenic human coronavirus pandemics have oc curred (e.g., SARS in 2003, MERS in 2012, and COVID-19 in 2020). COVID-19 has several [...]

Published
2022

3. A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome

Author

Takeda, Yukiko, primary, Ueki, Masahiro, additional, Matsuhiro, Junpei, additional, Walinda, Erik, additional, Tanaka, Takayuki, additional, Yamada, Masafumi, additional, Fujita, Hiroaki, additional, Takezaki, Shunichiro, additional, Kobayashi, Ichiro, additional, Tamaki, Sakura, additional, Nagata, Sanae, additional, Miyake, Noriko, additional, Matsumoto, Naomichi, additional, Osawa, Mitsujiro, additional, Yasumi, Takahiro, additional, Heike, Toshio, additional, Ohtake, Fumiaki, additional, Saito, Megumu K., additional, Toguchida, Junya, additional, Takita, Junko, additional, Ariga, Tadashi, additional, and Iwai, Kazuhiro, additional

Published
2024
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4. Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells

Author

Yoshinaga, Daisuke, Baba, Shiro, Makiyama, Takeru, Shibata, Hirofumi, Hirata, Takuya, Akagi, Kentaro, Matsuda, Koichi, Kohjitani, Hirohiko, Wuriyanghai, Yimin, Umeda, Katsutsugu, Yamamoto, Yuta, Conklin, Bruce R, Horie, Minoru, Takita, Junko, and Heike, Toshio

Subjects
Biological Sciences, Genetics, Human Genome, Orphan Drug, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Rare Diseases, Stem Cell Research - Induced Pluripotent Stem Cell, Cardiovascular, Heart Disease, Clinical Research, Stem Cell Research, Aetiology, 2.1 Biological and endogenous factors, Action Potentials, Adolescent, Adult, Case-Control Studies, Cell Differentiation, Child, Female, High-Throughput Screening Assays, Humans, Induced Pluripotent Stem Cells, Long QT Syndrome, Male, Middle Aged, Myocytes, Cardiac, Patch-Clamp Techniques, Phenotype, Potassium Channel Blockers, Sodium Channel Blockers, Tetrodotoxin, Young Adult, genome editing, induced pluripotent stem cell, long QT syndrome, multi-electrode array, phenotype-based diagnosis, Biochemistry and Cell Biology, Clinical Sciences, Biochemistry and cell biology
Abstract

For long QT syndrome (LQTS), recent progress in genome-sequencing technologies enabled the identification of rare genomic variants with diagnostic, prognostic, and therapeutic implications. However, pathogenic stratification of the identified variants remains challenging, especially in variants of uncertain significance. This study aimed to propose a phenotypic cell-based diagnostic assay for identifying LQTS to recognize pathogenic variants in a high-throughput manner suitable for screening. We investigated the response of LQT2-induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) following IKr blockade using a multi-electrode array, finding that the response to IKr blockade was significantly smaller than in Control-iPSC-CMs. Furthermore, we found that LQT1-iPSC-CMs and LQT3-iPSC-CMs could be distinguished from Control-iPSC-CMs by IKs blockade and INa blockade, respectively. This strategy might be helpful in compensating for the shortcomings of genetic testing of LQTS patients.

Published
2019

5. Integrative network analysis reveals biological pathways associated with Williams syndrome.

Author

Kimura, Ryo, Swarup, Vivek, Tomiwa, Kiyotaka, Gandal, Michael J, Parikshak, Neelroop N, Funabiki, Yasuko, Nakata, Masatoshi, Awaya, Tomonari, Kato, Takeo, Iida, Kei, Okazaki, Shin, Matsushima, Kanae, Kato, Toshihiro, Murai, Toshiya, Heike, Toshio, Geschwind, Daniel H, and Hagiwara, Masatoshi

Subjects
Chromosomes, Human, Pair 7, Humans, Williams Syndrome, MicroRNAs, RNA, Messenger, Gene Expression Profiling, Gene Expression, Child, Autism Spectrum Disorder, Williams syndrome, autism spectrum disorder, genetics, Congenital Structural Anomalies, Rare Diseases, Genetics, Biotechnology, Pediatric, Brain Disorders, Intellectual and Developmental Disabilities, 2.1 Biological and endogenous factors, Clinical Sciences, Psychology, Cognitive Sciences, Developmental & Child Psychology
Abstract

BackgroundWilliams syndrome (WS) is a neurodevelopmental disorder that has been attributed to heterozygous deletions in chromosome 7q11.23 and exhibits a variety of physical, cognitive, and behavioral features. However, the genetic basis of this phenotypic variability is unclear. In this study, we identified genetic clues underlying these complex phenotypes.MethodsNeurobehavioral function was assessed in WS patients and healthy controls. Total RNA was extracted from peripheral blood and subjected to microarray analysis, RNA-sequencing, and qRT-PCR. Weighted gene co-expression network analysis was performed to identify specific alterations related to intermediate disease phenotypes. To functionally interpret each WS-related module, gene ontology and disease-related gene enrichment were examined. We also investigated the micro (mi)RNA expression profiles and miRNA co-expression networks to better explain the regulation of the transcriptome in WS.ResultsOur analysis identified four significant co-expression modules related to intermediate WS phenotypes. Notably, the three upregulated WS-related modules were composed exclusively of genes located outside the 7q11.23 region. They were significantly enriched in genes related to B-cell activation, RNA processing, and RNA transport. BCL11A, which is known for its association with speech disorders and intellectual disabilities, was identified as one of the hub genes in the top WS-related module. Finally, these key upregulated mRNA co-expression modules appear to be inversely correlated with a specific downregulated WS-related miRNA co-expression module.ConclusionsDysregulation of the mRNA/miRNA network involving genes outside of the 7q11.23 region is likely related to the complex phenotypes observed in WS patients.

Published
2019

7. Associations between Broader Autism Phenotype and Dietary Intake: A Cross-Sectional Study (Japan Environment & Children's Study)

Author

Hirokawa, Kumi, Kimura, Takashi, Ikehara, Satoyo, Honjo, Kaori, Ueda, Kimiko, Sato, Takuyo, Iso, Hiroyasu, Kishi, Reiko, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, Kamijima, Michihiro, Heike, Toshio, Shima, Masayuki, Kawai, Yasuaki, Suganuma, Narufumi, Kusuhara, Koichi, and Katoh, Takahiko

Abstract

The purpose of the present study was to investigate associations of dietary intake including vitamin D, folate, and n-3 and n-6 polyunsaturated fatty acids (PUFA) in pregnant women with broad autism phenotype (BAP). The Japan Environment and Children's Study is a government-funded birth cohort study. All complete data of 92,011 were analyzed. The Japanese version of the Autism Spectrum Quotient was used to assess mothers' BAP level, and a food frequency questionnaire was used to estimate their dietary intake. Mothers with BAP consumed less vegetables, fruits, and fish and shellfish, and they consumed lower folate, vitamin C, vitamin D, and n-3 PUFA than their counterparts. Dietary intervention should be considered for pregnant women with high BAP scores.

Published
2020
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9. Atypical eosinophils as a biomarker of idiopathic pericardial effusion associated with transient abnormal myelopoiesis in Down syndrome

Author

Kobayashi, Kenichiro, primary, Motokura, Kouji, additional, Mizuta, Shumpei, additional, Yoshida, Saya, additional, Ohashi, Yuka, additional, Kawano, Marina, additional, Iwai, Atsushi, additional, Tanaka, Kuniaki, additional, Maihara, Toshiro, additional, Iio, Jun, additional, Nishida, Yoshinobu, additional, Wada, Takahito, additional, Ueshimo, Takeshi, additional, Usami, Ikuya, additional, and Heike, Toshio, additional

Published
2023
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10. Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors

Author

Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, and Heike, Toshio

Published
2021
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12. Association between family members and risk of postpartum depression in Japan: Does “who they live with” matter? -The Japan environment and Children's study

Author

Kishi, Reiko, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, Kamijima, Michihiro, Heike, Toshio, Iso, Hiroyasu, Shima, Masayuki, Kawai, Yasuaki, Suganuma, Narufumi, Kusuhara, Koichi, Katoh, Takahiko, Honjo, Kaori, Kimura, Takashi, Baba, Sachiko, Ikehara, Satoyo, Kitano, Naomi, and Sato, Takuyo

Published
2018
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16. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency

Author

Boisson, Bertrand, Honda, Yoshitaka, Ajiro, Masahiko, Bustamante, Jacinta, Bendavid, Matthieu, Gennery, Andrew R., Kawasaki, Yuri, Ichishima, Jose, Osawa, Mitsujiro, Nihira, Hiroshi, Shiba, Takeshi, Tanaka, Takayuki, Chrabieh, Maya, Bigio, Benedetta, Hur, Hong, Itan, Yuval, Liang, Yupu, Okada, Satoshi, Izawa, Kazushi, Nishikomori, Ryuta, Ohara, Osamu, Heike, Toshio, Abel, Laurent, Puel, Anne, Saito, Megumu K., Casanova, Jean-Laurent, Hagiwara, Masatoshi, and Yasumi, Takahiro

Subjects
Gene mutation -- Research, Protein deficiency -- Research, White blood cells -- Research, Stem cells, Dysplasia, Recurrence (Disease), Messenger RNA, Neurons, Immunodeficiency, RNA, Macrophages, Ectodermal dysplasia, Health care industry
Abstract

X-linked dominant incontinentia pigmenti (IP) and X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) are caused by loss-of-function and hypomorphic IKBKG (also known as NEMO) mutations, respectively. We describe a European mother with mild IP and a Japanese mother without IP, whose 3 boys with EDA-ID died from ID. We identify the same private variant in an intron of IKBKG, IVS4+866 C>T, which was inherited from and occurred de novo in the European mother and Japanese mother, respectively. This mutation creates a new splicing donor site, giving rise to a 44-nucleotide pseudoexon (PE) generating a frameshift. Its leakiness accounts for NF-[kappa]B activation being impaired but not abolished in the boys' cells. However, aberrant splicing rates differ between cell types, with WT NEMO mRNA and protein levels ranging from barely detectable in leukocytes to residual amounts in induced pluripotent stem cell-derived (iPSC-derived) macrophages, and higher levels in fibroblasts and iPSC-derived neuronal precursor cells. Finally, SRSF6 binds to the PE, facilitating its inclusion. Moreover, SRSF6 knockdown or CLK inhibition restores WT NEMO expression and function in mutant cells. A recurrent deep intronic splicing mutation in IKBKG underlies a purely quantitative NEMO defect in males that is most severe in leukocytes and can be rescued by the inhibition of SRSF6 or CLK., Introduction The IKBKG gene, also known as NEMO, encodes the NF-[kappa]B essential modulator (NEMO) (1,2). NEMO encodes the third regulatory subunit of the IkB kinase (IKK) complex and is also [...]

Published
2019
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18. Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors

Author

Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, and Heike, Toshio

Published
2020
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20. Data from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia

Author

Nemoto, Atsushi, primary, Saida, Satoshi, primary, Kato, Itaru, primary, Kikuchi, Jiro, primary, Furukawa, Yusuke, primary, Maeda, Yasuhiro, primary, Akahane, Koshi, primary, Honna-Oshiro, Hiroko, primary, Goi, Kumiko, primary, Kagami, Keiko, primary, Kimura, Shinya, primary, Sato, Yuko, primary, Okabe, Seiichi, primary, Niwa, Akira, primary, Watanabe, Kenichiro, primary, Nakahata, Tatsutoshi, primary, Heike, Toshio, primary, Sugita, Kanji, primary, and Inukai, Takeshi, primary

Published
2023
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21. Supplementary Figure from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia

Author

Nemoto, Atsushi, primary, Saida, Satoshi, primary, Kato, Itaru, primary, Kikuchi, Jiro, primary, Furukawa, Yusuke, primary, Maeda, Yasuhiro, primary, Akahane, Koshi, primary, Honna-Oshiro, Hiroko, primary, Goi, Kumiko, primary, Kagami, Keiko, primary, Kimura, Shinya, primary, Sato, Yuko, primary, Okabe, Seiichi, primary, Niwa, Akira, primary, Watanabe, Kenichiro, primary, Nakahata, Tatsutoshi, primary, Heike, Toshio, primary, Sugita, Kanji, primary, and Inukai, Takeshi, primary

Published
2023
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22. Supplementary Table from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia

Author

Nemoto, Atsushi, primary, Saida, Satoshi, primary, Kato, Itaru, primary, Kikuchi, Jiro, primary, Furukawa, Yusuke, primary, Maeda, Yasuhiro, primary, Akahane, Koshi, primary, Honna-Oshiro, Hiroko, primary, Goi, Kumiko, primary, Kagami, Keiko, primary, Kimura, Shinya, primary, Sato, Yuko, primary, Okabe, Seiichi, primary, Niwa, Akira, primary, Watanabe, Kenichiro, primary, Nakahata, Tatsutoshi, primary, Heike, Toshio, primary, Sugita, Kanji, primary, and Inukai, Takeshi, primary

Published
2023
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25. Correction to: Comparison of the social responsiveness scale-2 among individuals with Autism Spectrum Disorder and Williams Syndrome in Japan

Author

Hirai, Masahiro, primary, Asada, Kosuke, additional, Kato, Takeo, additional, Ikeda, Takahiro, additional, Hakuno, Yoko, additional, Ikeda, Ayaka, additional, Matsushima, Kanae, additional, Awaya, Tomonari, additional, Okazaki, Shin, additional, Kato, Toshihiro, additional, Funabiki, Yasuko, additional, Murai, Toshiya, additional, Heike, Toshio, additional, Hagiwara, Masatoshi, additional, Yamagata, Takanori, additional, Tomiwa, Kiyotaka, additional, and Kimura, Ryo, additional

Published
2022
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29. Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan

Author

Hirai, Masahiro, primary, Asada, Kosuke, additional, Kato, Takeo, additional, Ikeda, Takahiro, additional, Hakuno, Yoko, additional, Ikeda, Ayaka, additional, Matsushima, Kanae, additional, Awaya, Tomonari, additional, Okazaki, Shin, additional, Kato, Toshihiro, additional, Funabiki, Yasuko, additional, Murai, Toshiya, additional, Heike, Toshio, additional, Hagiwara, Masatoshi, additional, Yamagata, Takanori, additional, Tomiwa, Kiyotaka, additional, and Kimura, Ryo, additional

Published
2022
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35. Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Author

Saida, Satoshi, Watanabe, Ken-ichiro, Sato-Otsubo, Aiko, Terui, Kiminori, Yoshida, Kenichi, Okuno, Yusuke, Toki, Tsutomu, Wang, RuNan, Shiraishi, Yuichi, Miyano, Satoru, Kato, Itaru, Morishima, Tatsuya, Fujino, Hisanori, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Adachi, Souichi, Ito, Etsuro, Ogawa, Seishi, Ito, Mamoru, Nakahata, Tatsutoshi, and Heike, Toshio

Published
2013
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36. Identification of a High‐Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell–Based Phenotype Dissection

Author

Kawasaki, Yuri, Oda, Hirotsugu, Ito, Jun, Niwa, Akira, Tanaka, Takayuki, Hijikata, Atsushi, Seki, Ryosuke, Nagahashi, Ayako, Osawa, Mitsujiro, Asaka, Isao, Watanabe, Akira, Nishimata, Shigeo, Shirai, Tsuyoshi, Kawashima, Hisashi, Ohara, Osamu, Nakahata, Tatsutoshi, Nishikomori, Ryuta, Heike, Toshio, and Saito, Megumu K.

Published
2017
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38. Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

Author

Tanaka, Takayuki, Takahashi, Kazutoshi, Yamane, Mayu, Tomida, Shota, Nakamura, Saori, Oshima, Koichi, Niwa, Akira, Nishikomori, Ryuta, Kambe, Naotomo, Hara, Hideki, Mitsuyama, Masao, Morone, Nobuhiro, Heuser, John E., Yamamoto, Takuya, Watanabe, Akira, Sato-Otsubo, Aiko, Ogawa, Seishi, Asaka, Isao, Heike, Toshio, Yamanaka, Shinya, Nakahata, Tatsutoshi, and Saito, Megumu K.

Published
2012
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39. Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency

Author

Kawai, Tomoki, Nishikomori, Ryuta, Izawa, Kazushi, Murata, Yuuki, Tanaka, Naoko, Sakai, Hidemasa, Saito, Megumu, Yasumi, Takahiro, Takaoka, Yuki, Nakahata, Tatsutoshi, Mizukami, Tomoyuki, Nunoi, Hiroyuki, Kiyohara, Yuki, Yoden, Atsushi, Murata, Takuji, Sasaki, Shinya, Ito, Etsuro, Akutagawa, Hiroshi, Kawai, Toshinao, Imai, Chihaya, Okada, Satoshi, Kobayashi, Masao, and Heike, Toshio

Published
2012
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42. Primary Diffuse Leptomeningeal Atypical Teratoid/Rhabdoid Tumor Initially Masquerading as Guillain–Barré Syndrome: A Case Report and Literature Review

Author

Kobayashi, Kenichiro, additional, Tanaka, Kuniaki, additional, Iwai, Atsushi, additional, Taki, Junya, additional, Kitagawa, Masashi, additional, Hayashi, Tomoko, additional, Tsuzuki, Sadatoshi, additional, Yamamoto, Tetsuro, additional, Yoshioka, Takako, additional, Hirato, Junko, additional, Maihara, Toshiro, additional, Yamada, Keisuke, additional, Usami, Ikuya, additional, and Heike, Toshio, additional

Published
2022
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44. Sensitive detection of GATA1 mutations using complementary DNA‐based analysis for transient abnormal myelopoiesis associated with the Down syndrome

Author

Mizuta, Shumpei, primary, Yamane, Noriko, additional, Mononobe, Saya, additional, Watanabe, Asami, additional, Kitamura, Ritsuko, additional, Takahara, Tadamori, additional, Matsushima, Chieko, additional, Yoshida, Atushi, additional, Okamoto, Seiji, additional, Tanaka, Kuniaki, additional, Iwai, Atsushi, additional, Ikegawa, Atsuko, additional, Wada, Takahito, additional, Usami, Ikuya, additional, Maihara, Toshiro, additional, Komai, Takao, additional, Heike, Toshio, additional, Nishida, Yoshinobu, additional, and Kobayashi, Kenichiro, additional

Published
2021
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