523 results on '"Heijnen, Joseph. J."'
Search Results
2. Large-Scale Production of Secondary Metabolites by Plant Cell Cultures
3. Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization
4. Biochemical engineering’s grand adventure
5. Gas bubble induced oil recovery from emulsions stabilised by yeast components
6. In vivo kinetic analysis of the penicillin biosynthesis pathway using PAA stimulus response experiments
7. Stoichiometry and kinetics of single and mixed substrate uptake in Aspergillus niger
8. Model-Based Design of Superior Cell Factory: An Illustrative Example of Penicillium chrysogenum
9. Quantitative analysis of intracellular coenzymes in Saccharomyces cerevisiae using ion pair reversed phase ultra high performance liquid chromatography tandem mass spectrometry
10. Metabolic Flux Analysis, Modeling, and Engineering Solutions
11. Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses
12. Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells
13. Development of tools for quantitative intracellular metabolomics of Aspergillus niger chemostat cultures
14. An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data
15. Escherichia coli responds with a rapid and large change in growth rate upon a shift from glucose-limited to glucose-excess conditions
16. Towards a quantitative prediction of the fluxome from the proteome
17. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
18. Catching prompt metabolite dynamics in Escherichia coli with the BioScope at oxygen rich conditions
19. Model-based evaluation of cell retention by crossflow ultrafiltration during fed-batch fermentations with Escherichia coli
20. Model reduction and a priori kinetic parameter identifiability analysis using metabolome time series for metabolic reaction networks with linlog kinetics
21. The Hagen–Poiseuille pump for parallel fed-batch cultivations in microbioreactors
22. A system for accurate on-line measurement of total gas consumption or production rates in microbioreactors
23. Simultaneous quantification of free nucleotides in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution tandem mass spectrometry
24. Development and application of a differential method for reliable metabolome analysis in Escherichia coli
25. Optimization of cold methanol quenching for quantitative metabolomics of Penicillium chrysogenum
26. Development of quantitative metabolomics for Pichia pastoris
27. Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol
28. Isotopic non-stationary 13C gluconate tracer method for accurate determination of the pentose phosphate pathway split-ratio in Penicillium chrysogenum
29. A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
30. Quantitative analysis of metabolites in complex biological samples using ion-pair reversed-phase liquid chromatography–isotope dilution tandem mass spectrometry
31. Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics
32. Leakage-free rapid quenching technique for yeast metabolomics
33. Microbial metabolomics: past, present and future methodologies
34. Quantitative Metabolomics Using ID-MS
35. In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis
36. Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum
37. Short-term metabolome dynamics and carbon, electron, and ATP balances in chemostat-grown Saccharomyces cerevisiae CEN-PK 113-7D following a glucose pulse
38. Fast Sampling of the Cellular Metabolome
39. In vivo kinetics with rapid perturbation experiments in Saccharomyces cerevisiae using a second-generation BioScope
40. In vivo kinetics of primary metabolism in Saccharomyces cerevisiae studied through prolonged chemostat cultivation
41. Novel insights in transport mechanisms and kinetics of phenylacetic acid and penicillin-G in Penicillium chrysogenum
42. Measuring enzyme activities under standardized in vivo-like conditions for systems biology
43. Aerobic batch cultivation in micro bioreactor with integrated electrochemical sensor array
44. Quantitative determination of glucose transfer between cocurrent laminar water streams in a H-shaped microchannel
45. Development of a system for the on-line measurement of carbon dioxide production in microbioreactors: Application to aerobic batch cultivations of Candida utilis
46. Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites
47. Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats
48. Application of metabolome data in functional genomics: A conceptual strategy
49. Determination of elasticities, concentration and flux control coefficients from transient metabolite data using linlog kinetics
50. Substrate inhibition and product degradation during the reduction of 4-oxoisophorone by Saccharomyces cerevisiae
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