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325 results on '"Heijnen, C.J."'

15. Intranasal administration of human mesenchymal stem cells promote recovery from chemoradiation-induced cognitive and functional deficit in mice

Author

Chiu, G.S., primary, Kesler, S.R., additional, Wefel, J.S., additional, Sulman, E., additional, Lang, F., additional, Grosshans, D., additional, Ezhilarasan, R., additional, Liu, H.A., additional, Boukelmoune, N., additional, Kingsley, C., additional, Rao, V., additional, Gumin, J., additional, Ahmed, S., additional, Shpall, E.J., additional, Kavelaars, A., additional, and Heijnen, C.J., additional

Published
2017
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29. Neonatal glucocorticoid treatment: Long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14-17 year old adolescents

Author

Wolbeek, M. ter, Kavelaars, A., Vries, W.B. de, Tersteeg-Kamperman, M., Veen, S., Kornelisse, R.F., Weissenbruch, M. van, Baerts, W., Liem, K.D., Bel, F. van, Heijnen, C.J., Wolbeek, M. ter, Kavelaars, A., Vries, W.B. de, Tersteeg-Kamperman, M., Veen, S., Kornelisse, R.F., Weissenbruch, M. van, Baerts, W., Liem, K.D., Bel, F. van, and Heijnen, C.J.

Abstract

Item does not contain fulltext, Neonatal glucocorticoid (GC) treatment is used to prevent bronchopulmonary dysplasia (BPD) in prematurely born babies. In the 1990s, treatment regimens with relatively high doses of dexamethasone (DEX) were common. As an alternative, hydrocortisone (HC) was used. Earlier, we compared long-term effects of both GCs in children aged 7-10 and detected adverse effects of neonatal DEX treatment, but not of HC, on a range of outcomes. The aim of the current cohort study was to investigate whether long-term effects of neonatal DEX were maintained and whether effects of HC remained absent at adolescent age (14-17years). We compared 71 DEX-treated and 67 HC-treated adolescents. In addition, 71 adolescents who were not neonatally treated with GCs participated. All were born <32weeks of gestation. DEX-treated girls showed increased adrenocorticotropic hormone (ACTH) and cortisol responses in the Trier Social Stress Test. The cortisol awakening response was lower in HC-treated participants compared to untreated participants. Negative feedback function of the HPA-axis in the dexamethasone suppression test did not differ between groups. In contrast to our observations at the age of 7-10years, we did not observe group differences in mitogen-induced cytokine production at the age of 14-17years. DEX-treated girls showed more social problems and anxious/depressed behavior than HC-treated girls. Untreated girls showed more problem behavior as well. In conclusion, our results suggest that, especially in girls, neonatal DEX has a programming effect on the HPA-axis and on the ability to adjust to the environment. The loss of group differences on immune system measures indicate that potentially negative effects detected at a younger age subsided.

Published
2015

33. Chemoradiation abrogates inflammation, induces sickness behavior, activates hypoxia signaling pathways, and causes mitochondrial dysfunction in a syngeneic murine model of head and neck cancer

Author

Vichaya, E.G., primary, Molkentine, J.M., additional, Vermeer, D.W., additional, Walker, A.K., additional, Feng, R., additional, Holder, G., additional, Luu, K., additional, Mason, R.M., additional, Saligan, L., additional, Heijnen, C.J., additional, Kavelaars, A., additional, Mason, K.A., additional, Lee, J.H., additional, and Dantzer, R., additional

Published
2015
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37. Psychoneuroimmunologie van burnout

Author

Mommersteeg, P.M.C., van Doornen, L.J.P., Heijnen, C.J., Luyten, P., VandenBerghe, J., Van Houdenhove, B., and Medical and Clinical Psychology

Published
2010

38. The role and regulation of hypoxia-inducible factor-1 alpha expression in brain development and neonatal hypoxic-ischemic brain injury

Author

Fan, X., Heijnen, C.J., van der Kooij, M.A., Groenendaal, F., and van Bel, F.

Subjects
Necrosis, Neurology & Neurosurgery, Blood-Brain Barrier, Hypoxia-Ischemia, Brain, Brain, Animals, Humans, Apoptosis, Hypoxia-Inducible Factor 1, alpha Subunit
Abstract

During neonatal hypoxic-ischemic brain injury, activation of transcription of a series of genes is induced to stimulate erythropoiesis, anti-apoptosis, apoptosis, necrosis and angiogenesis. A key factor mediating these gene transcriptions is hypoxia-inducible factor-1alpha (HIF-1alpha). During hypoxia, HIF-1alpha protein is stabilized and heterodimerizes with HIF-1beta to form HIF-1, subsequently regulating the expression of target genes. HIF-1alpha participates in early brain development and proliferation of neuronal precursor cells. Under pathological conditions, HIF-1alpha is known to play an important role in neonatal hypoxic-ischemic brain injury: on the one hand, HIF-1alpha has neuroprotective effects whereas it can also have neurotoxic effects. HIF-1alpha regulates the transcription of erythropoietin (EPO), which induces several pathways associated with neuroprotection. HIF-1alpha also promotes the expression of vascular endothelial cell growth factor (VEGF), which is related to neovascularization in hypoxic-ischemic brain areas. In addition, HIF-1alpha has an anti-apoptotic effect by increasing the expression of anti-apoptotic factors such as EPO during mild hypoxia. The neurotoxic effects of HIF-1alpha are represented by its participation in the apoptotic process by increasing the stability of the tumor suppressor protein p53 during severe hypoxia. Moreover, HIF-1alpha plays a role in cell necrosis, by interacting with calcium and calpain. HIF-1alpha can also exacerbate brain edema via increasing the permeability of the blood-brain barrier (BBB). Given these properties, HIF-1alpha has both neuroprotective and neurotoxic effects after hypoxia-ischemia. These events are cell type specific and related to the severity of hypoxia. Unravelling of the complex functions of HIF-1alpha may be important when designing neuroprotective therapies for hypoxic-ischemic brain injury.

Published
2009

39. The HPA-axis and immune function in burnout

Author

Mommersteeg, P.M.C., Heijnen, C.J., Kavelaars, A., van Doornen, L.J.P., de Kloet, E.R., Oitzl, M., Vermetten, E., and Medical and Clinical Psychology

Published
2008

42. Cortisolregeling bij werknemers met burnout. Een pilotstudy

Author

Mommersteeg, P.M.C., Heijnen, C.J., Keijsers, G.P.J., Verbraak, M.J.P.M., and Doornen, L.J.P. van

Subjects
Experimental Psychopathology and Treatment
Abstract

Contains fulltext : 64054.pdf (Publisher’s version ) (Open Access)

Published
2004

49. The Psychophysiology of the burnout syndrome: cortisol sampling in burned out subjects

Author

Mommersteeg, P.M.C., Doornen, L.J.P. van, and Heijnen, C.J.

Subjects
endocrine system, burnout, HPA-axis, Sociale Wetenschappen, cortisol, Biologie
Abstract

Burnout symptoms of emotional exhaustion, depersonalisation and reduced personal accomplishment are the result of chronic stress. Specifically the hypothalamus pituitary adrenal (HPA)-axis is involved in long-term stress adaptation. Upon stimulation the HPA-axis releases cortisol from the adrenal medulla. Cortisol maintains the stress response and at the same time prevents overshoot of the stress response. The HPA-axis is interconnected with other regulatory systems involved in maintaining the energy balance, mood states, cognition, immunity, feeding and reproduction. A disrupted HPA-axis, with either hypo- or hyperfunctioning, could therefore act upon these systems, causing a whole array of different symptoms found in burnout individuals. The main goal of our study is to establish the occurrence of HPA-axis disregulation in burned out subjects. Burned out subjects are included before receiving treatment in a Dutch private health clinic. To date 40 burnout subjects (30 M) and 25 controls (18 M) have been included. The HPA-axis and burnout related questionnaires are sampled at the onset of treatment (T1), immediately after treatment (T2) and at follow up (T3) 6 months later. At each time point basic cortisol levels are measured non-invasively via cotton role saliva sampling. Daily sampling on two consecutive days includes the early morning rise (acute increase after awakening) and 3 further samples across the day. The dexamethason suppression test (0,5 mg o.d.) provides information on the negative feedback efficiency of the HPA-axis. A preceding pilot study on 22 burnout subjects (7 M, age 45 SD 8) and 21 controls (7 M, age 50 SD 7) has shown that the cortisol EMR level is lower for burnout subjects compared with the control group. The Early Morning Rise, and the day curve are not different. The burnout subjects also score sign. higher on the following questionnaires: SCl-90; general complaints, MBI; burnout, CIS-20; fatigue, BDI; depression, GSKS; sleep, CFQ; cognitive functioning. However a correlation between the cortisol data and the psychological complaints was not found. The first data of T1 sampling in the ongoing study will be shown.

Published
2003

50. Mechanical ventilation and the immune response [1]

Author

Myrianthefs, P. Batistaki, C. Venetsanou, K. Koutsopoulou, E. Evagelopoulou, P. Boutzouka, E. Baltopoulos, G. Plötz, F.B. Vreugdenhil, H.A.E. Slutsky, A.S. Zijlstra, J. Heijnen, C.J. Van Vught, H.

Published
2002

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