Search

Your search keyword '"Heggermont, Ward"' showing total 267 results
Start Over Author "Heggermont, Ward"
267 results on '"Heggermont, Ward"'

6. Association of Mild-to-Moderate Aortic Regurgitation With Outcomes in Heart Failure With Preserved Ejection Fraction

Author

De Colle, Cristina, Paolisso, Pasquale, Gallinoro, Emanuele, Bertolone, Dario Tino, Mileva, Niya, Fabbricatore, Davide, Valeriano, Chiara, Herman, Robert, Beles, Monika, De Oliveira, Elayne Kelen, Mancusi, Costantino, Heggermont, Ward, Collet, Carlos, Vanderheyden, Marc, De Luca, Nicola, Van Camp, Guy, Barbato, Emanuele, Bartunek, Jozef, and Penicka, Martin

Published
2023
Full Text
View/download PDF

8. Clinical Validation of a Virtual Planner for Coronary Interventions Based on Coronary CT Angiography

Author

Sonck, Jeroen, Nagumo, Sakura, Norgaard, Bjarne L., Otake, Hiromasa, Ko, Brian, Zhang, Jinlong, Mizukami, Takuya, Maeng, Michael, Andreini, Daniele, Takahashi, Yu, Jensen, Jesper Møller, Ihdayhid, Abdul, Heggermont, Ward, Barbato, Emanuele, Mileva, Niya, Munhoz, Daniel, Bartunek, Jozef, Updegrove, Adam, Collinsworth, Amy, Penicka, Martin, Van Hoe, Lieven, Leipsic, Jonathon, Koo, Bon-Kwon, De Bruyne, Bernard, and Collet, Carlos

Published
2022
Full Text
View/download PDF

10. Risk of myocardial infarction based on endothelial shear stress analysis using coronary angiography

Author

Candreva, Alessandro, Pagnoni, Mattia, Rizzini, Maurizio Lodi, Mizukami, Takuya, Gallinoro, Emanuele, Mazzi, Valentina, Gallo, Diego, Meier, David, Shinke, Toshiro, Aben, Jean-Paul, Nagumo, Sakura, Sonck, Jeroen, Munhoz, Daniel, Fournier, Stephane, Barbato, Emanuele, Heggermont, Ward, Cook, Stephane, Chiastra, Claudio, Morbiducci, Umberto, De Bruyne, Bernard, Muller, Oliver, and Collet, Carlos

Published
2022
Full Text
View/download PDF

11. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlos, primary, Munhoz, Daniel, additional, Mizukami, Takuya, additional, Sonck, Jeroen, additional, Matsuo, Hitoshi, additional, Shinke, Toshiro, additional, Ando, Hirohiko, additional, Ko, Brian, additional, Biscaglia, Simone, additional, Rivero, Fernando, additional, Engstrøm, Thomas, additional, Arslani, Ketina, additional, Leone, Antonio Maria, additional, van Nunen, Lokien X., additional, Fearon, William F., additional, Christiansen, Evald Høj, additional, Fournier, Stephane, additional, Desta, Liyew, additional, Yong, Andy, additional, Adjej, Julien, additional, Escaned, Javier, additional, Nakayama, Masafumi, additional, Eftekhari, Ashkan, additional, Zimmermann, Frederik M., additional, Sakai, Koshiro, additional, Storozhenko, Tatyana, additional, da Costa, Bruno R., additional, Campo, Gianluca, additional, West, Nick E.J., additional, De Potter, Tom, additional, Heggermont, Ward, additional, Buytaert, Dimitri, additional, Bartunek, Jozef, additional, Berry, Colin, additional, Collison, Damien, additional, Johnson, Thomas, additional, Amano, Tetsuya, additional, Perera, Divaka, additional, Jeremias, Allen, additional, Ali, Ziad, additional, Pijls, Nico H.J., additional, De Bruyne, Bernard, additional, and Johnson, Nils P., additional

Published
2024
Full Text
View/download PDF

13. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Collet, Carlo, Munhoz, Daniel, Mizukami, Takuya, Sonck, Jeroen, Matsuo, Hitoshi, Shinke, Toshiro, Ando, Hirohiko, Ko, Brian, Biscaglia, Simone, Rivero, Fernando, Engstrøm, Thoma, Arslani, Ketina, Leone, Antonio Maria, van Nunen, Lokien X, Fearon, William F, Christiansen, Evald Høj, Fournier, Stephane, Desta, Liyew, Yong, Andy, Adjej, Julien, Escaned, Javier, Nakayama, Masafumi, Eftekhari, Ashkan, Zimmermann, Frederik M, Sakai, Koshiro, Storozhenko, Tatyana, da Costa, Bruno R, Campo, Gianluca, West, Nick E J, De Potter, Tom, Heggermont, Ward, Buytaert, Dimitri, Bartunek, Jozef, Berry, Colin, Collison, Damien, Johnson, Thoma, Amano, Tetsuya, Perera, Divaka, Jeremias, Allen, Ali, Ziad, Pijls, Nico H J, De Bruyne, Bernard, Johnson, Nils P, and Leone, Antonio Maria (ORCID:0000-0002-1276-9883)

Abstract

Background: Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularisation and procedural outcomes. Methods: This prospective, investigator-initiated, single-arm, multicentre study enrolled patients with at least one epicardial lesion with an FFR ≤ 0.80 scheduled for PCI. Manual FFR pullbacks were employed to calculate PPG. The primary outcome of optimal revascularisation was defined as a post-PCI FFR ≥ 0.88. Results: 993 patients with 1044 vessels were included. The mean FFR was 0.68 ± 0.12, PPG 0.62 ± 0.17, and post-PCI FFR 0.87 ± 0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65, 95% CI 0.61-0.69, p<0.001) and demonstrated excellent predicted capacity for optimal revascularisation (AUC 0.82, 95% CI 0.79-0.84, p<0.001). Conversely, FFR alone did not predict revascularisation outcomes (AUC 0.54, 95% CI 0.50-0.57). PPG influenced treatment decisions in 14% of patients, redirecting them from PCI to alternative treatment modalities. Periprocedural myocardial infarction occurred more frequently in patients with low PPG (<0.62) compared to those with focal disease (OR 1.71, 95% CI: 1.00-2.97). Conclusions: Pathophysiological CAD patterns distinctly affect the safety and effectiveness of PCI. The PPG showed an excellent predictive capacity for optimal revascularisation and demonstrated added value compared to a FFR measurement.

Published
2024

17. Myocardial Work and Risk Stratification in Patients with Severe Aortic Valve Stenosis Referred for Transcatheter Aortic Valve Replacement

Author

Moya, Ana, primary, de Oliveira, Elayne Kelen, additional, Derule, Leen, additional, Beles, Monika, additional, Buytaert, Dimitri, additional, Goethals, Marc, additional, Verstreken, Sofie, additional, Dierckx, Riet, additional, Bartunek, Jozef, additional, Heggermont, Ward A., additional, Wyffels, Eric, additional, and Vanderheyden, Marc, additional

Published
2024
Full Text
View/download PDF

19. Detection of transthyretin amyloid cardiomyopathy by automated data extraction from electronic health records

Author

Moya, Ana, primary, Oeste, Clara L., additional, Beles, Monika, additional, Verstreken, Sofie, additional, Dierckx, Riet, additional, Heggermont, Ward, additional, Bartunek, Jozef, additional, Bogaerts, Eline, additional, Masuy, Imke, additional, Hens, Dries, additional, Bertolone, Dario, additional, and Vanderheyden, Marc, additional

Published
2023
Full Text
View/download PDF

26. Cardio–renal–metabolic syndrome: clinical features and dapagliflozin eligibility in a real‐world heart failure cohort

Author

Beles, Monika, primary, Masuy, Imke, additional, Verstreken, Sofie, additional, Bartunek, Jozef, additional, Dierckx, Riet, additional, Heggermont, Ward, additional, Oeste, Clara, additional, De Boeck, Marieke, additional, Fovel, Isabelle, additional, Maris, Michael, additional, Vermeulen, Zarha, additional, and Vanderheyden, Marc, additional

Published
2023
Full Text
View/download PDF

28. Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers.

Author

Bosman, Matthias, Krüger, Dustin, Assche, Charles Van, Boen, Hanne, Neutel, Cédric, Favere, Kasper, Franssen, Constantijn, Martinet, Wim, Roth, Lynn, Meyer, Guido R Y De, Cillero-Pastor, Berta, Delrue, Leen, Heggermont, Ward, Craenenbroeck, Emeline M Van, and Guns, Pieter-Jan

Subjects
CARDIOTOXICITY, TOXICITY testing, ENDOTHELIUM diseases, ARTERIAL diseases, HEART diseases
Abstract

Aims Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular toxicity, represented by arterial stiffness and endothelial dysfunction. Both parameters are of interest for cardiovascular risk stratification as they are independent predictors of future cardiovascular events in the general population. However, the time course of DOX-induced cardiovascular toxicity remains unclear. Moreover, current biomarkers for cardiovascular toxicity prove insufficient. Here, we longitudinally evaluated functional and molecular markers of DOX-induced cardiovascular toxicity in a murine model. Molecular markers were further validated in patient plasma. Methods and results DOX (4 mg/kg) or saline (vehicle) was administered intra-peritoneally to young, male mice weekly for 6 weeks. In vivo cardiovascular function and ex vivo arterial stiffness and vascular reactivity were evaluated at baseline, during DOX therapy (Weeks 2 and 4) and after therapy cessation (Weeks 6, 9, and 15). Left ventricular ejection fraction (LVEF) declined from Week 4 in the DOX group. DOX increased arterial stiffness in vivo and ex vivo at Week 2, which reverted thereafter. Importantly, DOX-induced arterial stiffness preceded reduced LVEF. Further, DOX impaired endothelium-dependent vasodilation at Weeks 2 and 6, which recovered at Weeks 9 and 15. Conversely, contraction with phenylephrine was consistently higher in the DOX-treated group. Furthermore, proteomic analysis on aortic tissue identified increased thrombospondin-1 (THBS1) and alpha-1-antichymotrypsin (SERPINA3) at Weeks 2 and 6. Up-regulated THBS1 and SERPINA3 persisted during follow-up. Finally, THBS1 and SERPINA3 were quantified in plasma of patients. Cancer survivors with anthracycline-induced cardiotoxicity (AICT; LVEF < 50%) showed elevated THBS1 and SERPINA3 levels compared with age-matched control patients (LVEF ≥ 60%). Conclusions DOX increased arterial stiffness and impaired endothelial function, which both preceded reduced LVEF. Vascular dysfunction restored after DOX therapy cessation, whereas cardiac dysfunction persisted. Further, we identified SERPINA3 and THBS1 as promising biomarkers of DOX-induced cardiovascular toxicity, which were confirmed in AICT patients. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

29. Serial Non-Invasive Myocardial Work Measurements for Patient Risk Stratification and Early Detection of Cancer Therapeutics-Related Cardiac Dysfunction in Breast Cancer Patients: A Single-Centre Observational Study

Author

Moya, Ana, primary, Buytaert, Dimitri, additional, Beles, Monika, additional, Paolisso, Pasquale, additional, Duchenne, Jürgen, additional, Huygh, Greet, additional, Langmans, Ciska, additional, Roelstraete, Adelheid, additional, Verstreken, Sofie, additional, Goethals, Marc, additional, Dierckx, Riet, additional, Bartunek, Jozef, additional, Penicka, Martin, additional, Van Camp, Guy, additional, Heggermont, Ward A., additional, and Vanderheyden, Marc, additional

Published
2023
Full Text
View/download PDF

31. Utilizing longitudinal data in assessing all‐cause mortality in patients hospitalized with heart failure

Author

Herman, Robert, primary, Vanderheyden, Marc, additional, Vavrik, Boris, additional, Beles, Monika, additional, Palus, Timotej, additional, Nelis, Olivier, additional, Goethals, Marc, additional, Verstreken, Sofie, additional, Dierckx, Riet, additional, Penicka, Martin, additional, Heggermont, Ward, additional, and Bartunek, Jozef, additional

Published
2022
Full Text
View/download PDF

32. Initial experience of left bundle branch area pacing using stylet‐driven pacing leads: A multicenter study

Author

De Pooter, Jan, primary, Ozpak, Emine, additional, Calle, Simon, additional, Peytchev, Peter, additional, Heggermont, Ward, additional, Marchandise, Sebastien, additional, Provenier, Frank, additional, Francois, Bart, additional, Anné, Wim, additional, Pollet, Peter, additional, Barbraud, Cynthia, additional, Gillis, Kris, additional, Timmermans, Frank, additional, Van Heuverswyn, Frederic, additional, Tung, Roderick, additional, Wauters, Aurélien, additional, and le Polain de Waroux, Jean‐Benoit, additional

Published
2022
Full Text
View/download PDF

33. Initial experience of left bundle branch area pacing using stylet-driven pacing leads: A multicenter study.

Author

UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, De Pooter, Jan, Ozpak, Emine, Calle, Simon, Peytchev, Peter, Heggermont, Ward, Marchandise, Sebastien, Provenier, Frank, Francois, Bart, Anné, Wim, Pollet, Peter, Barbraud, Cynthia, Gillis, Kris, Timmermans, Frank, Van Heuverswyn, Frederic, Tung, Roderick, Wauters, Aurélien, le Polain de Waroux, Jean-Benoit, UCL - (SLuc) Département cardiovasculaire, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, De Pooter, Jan, Ozpak, Emine, Calle, Simon, Peytchev, Peter, Heggermont, Ward, Marchandise, Sebastien, Provenier, Frank, Francois, Bart, Anné, Wim, Pollet, Peter, Barbraud, Cynthia, Gillis, Kris, Timmermans, Frank, Van Heuverswyn, Frederic, Tung, Roderick, Wauters, Aurélien, and le Polain de Waroux, Jean-Benoit

Abstract

Left bundle branch area pacing (LBBAP) has been performed exclusively using lumen-less pacing leads (LLL) with fixed helix design. This registry study explores the safety and feasibility of LBBAP using stylet-driven leads (SDL) with extendable helix design in a multicenter patient population. This study prospectively enrolled consecutive patients who underwent LBBAP for bradycardia pacing or heart failure indications at eight Belgian hospitals. LBBAP was attempted using SDL (Solia S60; Biotronik) delivered through dedicated delivery sheath (Selectra3D). Implant success, complications, procedural, and pacing characteristics were recorded at implant and follow-up. The study enrolled 353 patients (mean age 76 ± 39 years, 43% female). The mean number of implants per center was 25 (range: 5-162). Overall, LBBAP with SDL was successful in 334/353 (94%), varying from 93% to 100% among centers. Pacing response was labeled as left bundle branch pacing in 73%, whereas 27% were labeled as myocardial capture. Mean paced QRS duration and stimulus to left ventricular activation time measured 126 ± 21 ms and 74 ± 17. SDL-LBBAP resulted in low pacing thresholds (0.6 ± 0.4 V at 0.4 ms), which remained stable at 12 months follow-up (0.7 ± 0.3, p = .291). Lead revisions for SDL-LBBAP occurred in 5 (1.4%) patients occurred during a mean follow up of 9 ± 5 months. Five (1.4%) septal coronary artery fistulas and 8 (2%) septal perforations occurred, none of them causing persistent ventricular septal defects. The use of SDL to achieve LBBAP is safe and feasible, characterized by high implant success in low and high volume centers, low complication rates, and stable low pacing thresholds.

Published
2022

35. Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Author

Schoors, Sandra, Bruning, Ulrike, Missiaen, Rindert, Queiroz, Karla C.S., Borgers, Gitte, Elia, Ilaria, Zecchin, Annalisa, Cantelmo, Anna Rita, Christen, Stefan, Goveia, Jermaine, Heggermont, Ward, Godde, Lucica, Vinckier, Stefan, Van Veldhoven, Paul P., Eelen, Guy, Schoonjans, Luc, Gerhardt, Holger, Dewerchin, Mieke, Baes, Myriam, De Bock, Katrien, Ghesquiere, Bart, Lunt, Sophia Y., Fendt, Sarah-Maria, and Carmeliet, Peter

Subjects
Endothelium -- Physiological aspects, Fatty acids -- Physiological aspects, Deoxyribonucleotides -- Physiological aspects, Carbon -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells. Reduction of FAO in endothelial cells did not cause energy depletion or disturb redox homeostasis, but impaired de novo nucleotide synthesis for DNA replication. Isotope labelling studies in control endothelial cells showed that fatty acid carbons substantially replenished the Krebs cycle, and were incorporated into aspartate (a nucleotide precursor), uridine monophosphate (a precursor of pyrimidine nucleoside triphosphates) and DNA. CPT1A silencing reduced these processes and depleted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates. Acetate (metabolized to acetyl-CoA, thereby substituting for the depleted FAO-derived acetyl-CoA) or a nucleoside mix rescued the phenotype of CPT1A-silenced endothelial cells. Finally, CPT1 blockade inhibited pathological ocular angiogenesis in mice, suggesting a novel strategy for blocking angiogenesis., Angiogenesis relies on the proliferation and migration of endothelial cells (1). The importance of endothelial cell proliferation for expansive growth of the vascular network has long been recognized (2). While [...]

Published
2015
Full Text
View/download PDF

40. Hemodynamic Response to Acute Volume Load and Endomyocardial NO-synthase Gene Expression in Heart Transplant Recipients

Author

Kobediona, Monika, Bartunek, Jozef, Delrue, Leen, Van Durme, Frederik, Lau, Chirik Wah, Moya, Ana, Verstreken, Sofie, Heggermont, Ward, Dierckx, Riet, Goethals, Marc, and Vanderheyden, Marc

Subjects
DIASTOLIC FUNCTION, Transplantation, Science & Technology, PRESERVED EJECTION FRACTION, FLUID CHALLENGE, STATEMENT, REST, FAILURE, NITRIC-OXIDE SYNTHASE, EXERCISE HEMODYNAMICS, DIAGNOSIS, Life Sciences & Biomedicine, VENTRICULAR FILLING PRESSURES
Abstract

UNLABELLED: A pulmonary capillary wedge pressure (PCWP) >18 mm Hg following volume load has been proposed as a partition value for the detection of heart failure with preserved ejection fraction. As hemodynamic changes in filling pressures (FP) have been attributed to a nitric oxide (NO)-mediated rightward shift of the pressure-volume relationship, we investigated the hemodynamic response to volume load in heart transplant recipients (HTx) and examined the role of inducible NO synthase (iNOS) gene expression on diastolic function changes. METHODS: In 36 HTx, FPs were measured before and after volume load, following which Starling curves were constructed using PCWP and cardiac index (CI). Patients were categorized into those with normal (group A, n = 21) and abnormal hemodynamics (group B, n = 15, PCWP >15 mm Hg at rest or >18 mm Hg following volume load). For the establishment of the potential role of NO, endomyocardial iNOS gene expression level was measured. RESULTS: Except for PCWP (P < 0.001) and mean pulmonary artery pressure (P < 0.001) no differences in age, baseline characteristics, and ejection fraction were observed between both groups, and volume load significantly increased PCWP in both groups (group A: P < 0.001 and group B: P < 0.001) without any change in heart rate. Interestingly, volume load significantly increased CI in group A (P < 0.001) but not in group B (P = 0.654), and the Starling curves revealed a higher CI at any given PCWP in group A together with significantly higher iNOS gene expression (P = 0.009). CONCLUSIONS: In HTx, volume load increases FP and unmasks the presence of left ventricular diastolic dysfunction. Interestingly, following saline load group B shows a blunted Starling response, with higher PCWP and lack of CI increase at any given PCWP. The higher iNOS gene expression level in group A suggests a potential role of NO as mediator of diastolic function. ispartof: TRANSPLANTATION DIRECT vol:8 issue:6 ispartof: location:United States status: published

Published
2021

41. Performance of non‐invasive myocardial work to predict the first hospitalization for de novo heart failure with preserved ejection fraction

Author

Paolisso, Pasquale, primary, Gallinoro, Emanuele, additional, Mileva, Niya, additional, Moya, Ana, additional, Fabbricatore, Davide, additional, Esposito, Giuseppe, additional, De Colle, Cristina, additional, Beles, Monika, additional, Spapen, Jerrold, additional, Heggermont, Ward, additional, Collet, Carlos, additional, Van Camp, Guy, additional, Vanderheyden, Marc, additional, Barbato, Emanuele, additional, Bartunek, Jozef, additional, and Penicka, Martin, additional

Published
2021
Full Text
View/download PDF

43. Abstract 13836: Unbiased Deep Learning Approach Utilizing Longitudinal Data in Assessing All-Cause Mortality in Patients With a De Novo or Worsened Heart Failure

Author

Herman, Robert, primary, Vanderheyden, Marc, additional, Vavrik, Boris, additional, Beles, Monika, additional, Palus, Timotej, additional, Kepesiova, Zuzana, additional, Goethals, Marc, additional, Verstreken, Sofie, additional, Dierckx, Riet, additional, Heggermont, Ward, additional, and Bartunek, Jozef, additional

Published
2021
Full Text
View/download PDF

45. Validation of Coronary Angiography-Derived Vessel Fractional Flow Reserve in Heart Transplant Patients with Suspected Graft Vasculopathy

Author

Mileva, Niya, primary, Nagumo, Sakura, additional, Gallinoro, Emanuele, additional, Sonck, Jeroen, additional, Verstreken, Sofie, additional, Dierkcx, Riet, additional, Heggermont, Ward, additional, Bartunek, Jozef, additional, Goethals, Marc, additional, Heyse, Alex, additional, Barbato, Emanuele, additional, De Bruyne, Bernard, additional, Collet, Carlos, additional, and Vanderheyden, Marc, additional

Published
2021
Full Text
View/download PDF

49. unexpected cause of a swollen pacemaker pocket: a case report.

Author

Popelier, Bert, Vanheste, Ruben, Cuypers, Sofie, and Heggermont, Ward

Subjects
CARDIAC pacemakers, COUGH, SQUAMOUS cell carcinoma, ULTRASONIC imaging
Abstract

Background A complication originating from the pacemaker pocket after device implantation can most often be explained by a post-operative pocket haematoma, or, less frequently, by a pocket infection. Both conditions need immediate assessment, dedicated treatment, and specialized follow-up. In rare cases, however, a swollen pacemaker pocket has an alternative diagnosis, which is exemplified by the following case. Case summary A 70-year-old male patient had a-specific symptoms of fatigue, dyspnoea, and coughing for some weeks. He also noted an evident, new swelling of his pacemaker pocket several months after pacemaker implantation, a procedure that was performed in a high-volume center and without any complication. Ultrasound imaging of the pocket suggested the presence of a soft tissue mass with increased vascularity, rather than a fluid collection or a late organized haematoma. Ultrasound-guided biopsy of the mass was obtained for histopathology analysis and revealed a well-differentiated invasive squamous cell carcinoma. Additional PET-CT imaging demonstrated multiple fluorodeoxyglucose-avid hotspots: a voluminous lesion in the left lung hilum, smaller lesions in the liver, some mediastinal lymph nodes, several bone lesions, and a large mass surrounding the pacemaker. The multidisciplinary oncologic specialty team concluded that the patient had an aggressive metastatic lung carcinoma. The patient refused to undergo further treatment and died 1.5 months after diagnosis. Discussion To the best of our knowledge, we did not find any earlier reports of a squamous cell carcinoma of the lung spreading to a pacemaker pocket. Presentation of a primary tumour or a metastasis in a pacemaker pocket is extremely rare. Ultrasound imaging with ultrasound-guided biopsy is a fast and reliable method to sample the tissue and to obtain a reliable diagnosis. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results