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3. National Scientific Medical Meeting 1994 Abstracts

Author

Carson, K. D., Grimes, S. B., McGinley, J. M., Thornton, M. T., Mulhall, J., Bourke, A. M., McCrory, C., Marsh, B., Hone, R., Phelan, D., White, M., Fabry, J., Hughes, D., Carson, K., Donnelly, M., Shanahan, E., Fitzpatrick, G. J., Bourke, M., Warde, D., Buggy, D., Hughes, N., Taylor, A., Dowd, N., Markham, T., Blunnie, W., Nicholson, G., O’Leary, E., Cunningham, A. J., Dwyer, R., McMechan, S., Cullen, C., Dempsey, G., Wright, G., MacKenzie, G., Anderson, J., Adgey, J., Walsh, M., O’Callaghan, P., Graham, I., O’Hare, J. A., Geoghegan, M., Iman, N., Shah, P., Chander, R., Lavin, F., Daly, K., Johnston, P. W., Imam, Z., Adgey, A. A. J., Rusk, R. A., Richardson, S. G., Hale, A., Kinsella, B. M., FitzGerald, G. A., King, G., Crean, P., Gearty, G., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Upton, J., D’Arcy, G., Stinson, J., Cooke, T., Colgan, M. P., Hall, M., Tyrrell, J., Gaffney, K., Grouden, M., Moore, D. J., Shanik, G., Feely, J., Delanty, N., Reilly, M., Lawson, J. A., Fitzgerald, D. J., Reilly, M. P., McAdam, B. F., Bergin, C., Walshe, M. J., Herity, N. A., Allen, J. D., Silke, B., Singh, H. P., O’Neill, S., Hargrove, M., Coleman, E., Shorten, E., Aherne, T., Kelly, B. E., Hill, D. H., McIlrath, E., Morrow, B. C., Lavery, G. G., Blackwood, B., Fee, J. P. H., Kevin, L., Doran, M., Tansey, D., Boylan, I., McShane, A. J., O’Reilly, G., Tuohy, B., Grainger, P., Larkin, T., Mahady, J., Malone, J., Condon, C., Donoghue, T., O’Leary, J., Lyons, J. F., Tay, Y. K., Tham, S. N., Khoo Tan, H. S., Gibson, G., O’Grady, A., Leader, M., Walshe, J., Carmody, M., Donohoe, J., Murphy, G. M., O’Connor, W., Barnes, L., Watson, R., Darby, C., O’Moore, R., Mulcahy, F., O’Toole, E., O’Briain, D. S., Young, M. M., Buckley, D., Healy, E., Rogers, S., Ni Scannlain, N., McKenna, M. J., McBrinn, Y., Murray, B., Freaney, R., Barrett, E., Razza, Q., Abuaisha, F., Powell, D., Murray, T. M., Powell, A. M., O’Mongain, E., O’Neill, J., Kernan, R. P., O’Connor, P., Clarke, D., Fearon, U., Cunningham, S. K., McKenna, T. J., Hayes, F., Heffernan, A., Sheahan, K., Harper, R., Johnston, G. D., Atkinson, A. B., Sheridan, B., Bell, P. M., Heaney, A. P., Loughrey, G., McCance, D. R., Hadden, D. R., Kennedy, A. L., McNamara, P., O’Shaughnessy, C., Loughrey, H. C., Reid, I., Teahan, S., Caldwell, M., Walsh, T. N., McSweeney, J., Hennessy, T. P., Caldwell, M. T. P., Byrne, P. J., Hennessy, T. P. J., El-Magbri, A. A., Stevens, F. M., O’Sullivan, R., McCarthy, C. F., Laundon, J., Heneghan, M. A., Kearns, M., Goulding, J., Egan, E. L., McMahon, B. P., Hegarty, F., Malone, J. F., Merriman, R., MacMathuna, P., Crowe, J., Lennon, J., White, P., Clarke, E., Prabhakar, M. C., Ryan, E., Graham, D., Yeoh, P. L., Kelly, P., McKeogh, D., O’Keane, C., Kitching, A., Mulligan, E., Gorey, T. F., Mahmud, N., O’Connell, M., Goggins, M., Keeling, P. W. N., Weir, D. G., Kelleher, D., McDonald, G. S. A., Maguire, D., O’Sullivan, G., Harvey, B., Cherukuri, A., McGrath, J. P., Timon, C., Lawlor, P., O’Shea, J., Buckley, M., English, L., Walsh, T., O’Morain, C., Lavelle, S. M., Kanagaratnam, B., Harding, B., Murphy, B., Kavanagh, J., Kerr, D., Lavelle, E., O’Gorman, T., Liston, S., Fitzpatrick, C., Fitzpatrick, P., Turner, M., Murphy, A. W., Cafferty, D., Dowling, J., Bury, G., Kaf Al-Ghazal, S., Zimmermann, E., O’Donoghue, J., McCann, J., Sheehan, C., Boissel, L., Lynch, M., Cryan, B., Fanning, S., O’Meara, D., Fennell, J., Byrne, P. M., Lyons, D., Mulcahy, R., Pooransingh, A., Walsh, J. B., Coakley, D., O’Neill, D., Ryall, N., Connolly, P., Namushi, R., Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., McCann, S. R., Pamphilon, D., Reidy, M., Madden, M., Finch, T., Borton, M., Barnes, C. A., Lawlor, S. E., Gardiner, N., Egan, L. J., Orren, A., Doherty, J., Curran, C., O’Hanlon, D., Kent, P., Kerin, M., Maher, D., Given, H. F., Lynch, S., McManus, R., O’Farrelly, C., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., Morris, T. C. M., Maguire, H., Davidson, F., Kaminski, G. Z., Butler, K., Hillary, I. B., Parfrey, N. A., Crowley, B., McCreary, C., Keane, C., O’Reilly, M., Goh, J., Kennedy, M., Fitzgerald, M., Scott, T., Murphy, S., Hildebrand, J., Holliman, R., Smith, C., Kengasu, K., Riain, U. Ni, Cormican, M., Flynn, J., Glennon, M., Smith, T., Whyte, D., Keane, C. T., Barry, T., Noone, D., Maher, M., Dawson, M., Gilmartin, J. J., Gannon, F., Eljamel, M. S., Allcut, D., Pidgeon, C. N., Phillips, J., Rawluk, D., Young, S., Toland, J., Deveney, A. M., Waddington, J. L., O’Brien, D. P., Hickey, A., Maguire, E., Phillips, J. P., Al-Ansari, N., Cunney, R., Smyth, E., Sharif, S., Eljamel, M., Pidgeon, C., Maguire, E. A., Burke, E. T., Staunton, H., O’Riordan, J. I., Hutchinson, M., Norton, M., McGeeney, B., O’Connor, M., Redmond, J. M. T., Feely, S., Boyle, G., McAuliffe, F., Foley, M., Kelehan, P., Murphy, J., Greene, R. A., Higgins, J., Darling, M., Byrne, P., Kondaveeti, U., Gordon, A. C., Hennelly, B., Woods, T., Harrison, R. F., Geary, M., Sutherst, J. R., Turner, M. J., DeLancey, J. O. L, Donnelly, V. S., O’Connell, P. R., O’Herlihy, C., Barry-Kinsella, C., Sharma, S. C., Drury, L., Lewis, S., Stratton, J., Ni Scanaill, S., Stuart, B., Hickey, K., Coulter-Smith, S., Moloney, A., Robson, M. S., Murphy, M., Keane, D., Stronge, J., Boylan, P., Gonsalves, R., Blankson, S., McGuinness, E., Sheppard, B., Bonnar, J., MacDonagh-White, C. M., Kelleher, C. C., Newell, J., White, O., Young, Y., Hallahan, C., Carroll, K., Tipton, K., McDermott, E. W., Reynolds, J. V., Nolan, N., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Grimes, H., Gallagher, S., O’Hanlon, D. M., Strattan, J., Lenehan, P., Robson, M., Cusack, Y. A., O’Riordain, D., Mercer, P. M., Smyth, P. P. A., Gallagher, H. J., Moule, B., Cooke, T. G., McArdle, C. S., Burke, C., Vance, A., Saidtéar, C., Early, A., Eustace, P., Maguire, L., Cullinane, A. B. P., Prosser, E. S., Coca-Prados, M., Harvey, B. J., Saidléar, C., Orwa, S., Fitzsimons, R. B., Bradley, O., Hogan, M., Zimmerman, L., Wang, J., Kuliszewski, M., Liu, J., Post, M., Premkumar, Conran, M. J., Nolan, G., Duff, D., Oslizlok, P., Denham, B., O’Connell, P. A, Birthistle, K., Hitchcock, R., Carrington, D., Calvert, S., Holmes, K., Smith, D. F., Hetherton, A. M., Mott, M. G., Oakhill, A., Foreman, N., Foot, A., Dixon, J., Walsh, S., Mortimer, G., O’Sullivan, C., Kilgallen, C. M., Sweeney, E. C., Brayden, D. J., Kelly, J. G., McCormack, P. M. E., Hayes, C., Johnson, Z., Dack, P., Hosseini, J., O’Connell, T., Hemeryck, L., Condren, L., McCormack, P., McAdam, B., Lawson, J., Keimowitz, R., O’Leary, A., Pilkington, R., Adebayo, G. I., Gaffney, P., McGettigan, P., McManus, J., O’Shea, B., Wen, Y., Killalea, S., Golden, J., Swanwick, G., Clare, A. W., Mulvany, F., Byrne, M., O’Callaghan, E., Byrne, H., Cannon, N., Kinsella, T., Cassidy, B., Shepard, N., Horgan, R., Larkin, C., Cotter, D., Coffey, V. P., Sham, P. C., Murray, L. H., Lane, A., Kinsella, A., Murphy, P., Colgan, K., Sloan, D., Gilligan, P., McEnri, J., Ennis, J. T., Stack, J., Corcoran, E., Walsh, D., Thornton, L., Temperley, I., Lawlor, E., Tobin, A., Hillary, I., Nelson, H. G., Martin, M., Ryan, F. M., Christie, M. A., Murray, D., Keane, E., Holmes, E., Hollyer, J., Strangeways, J., Foster, P., Stanwell-Smith, R., Griffin, E., Conlon, T., Hayes, E., Clarke, T., Fogarty, J., Moloney, A. C., Killeen, P., Farrell, S., Clancy, L., Hynes, M., Conlon, C., Foley-Nolan, C., Shelley, E., Collins, C., McNamara, E., Hayes, B., Creamer, E., LaFoy, M., Costigan, P., Al fnAnsari, N., Cunney, R. J., Smyth, E. G., Johnson, H., McQuoid, G., Gilmer, B., Browne, G., Keogh, J. A. B., Jefferson, A, Smith, M., Hennessy, S., Burke, C. M., Sreenan, S., Power, C. K., Pathmakanthan, S., Poulter, L. W., Chan, A., Sheehan, M., Maguire, M., O’Connor, C. M., FitzGerald, M. X., Southey, A., Costello, C. M., McQuaid, K., Urbach, V., Thomas, S., Horwitz, E. R., Mulherin, D., FitzGerald, O., Bresnihan, B., Kirk, G., Veale, D. J., Belch, J. J. F., Mofidi, A., Mofidi, R., Quigley, C., McLaren, M., Veale, D., D’Arrigo, C., Couto, J. Candal, Woof, J., Greer, M., Cree, I., Belch, J., Hone, S., Fenton, J., Hamilton, S., and McShane, D.

Published
1994
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14. Randomized controlled trial comparing Parent Led Therapist Supervised Articulation Therapy (PLAT) with routine intervention for children with speech disorders associated with cleft palate.

Author

Sweeney T, Hegarty F, Powell K, Deasy L, Regan MO, and Sell D

Subjects
Adult, Child, Child, Preschool, Female, Health Services Accessibility, Humans, Ireland, Male, Speech Disorders etiology, Treatment Outcome, United Kingdom, Cleft Palate complications, Parents education, Patient Participation methods, Speech Disorders therapy, Speech Therapy methods
Abstract

Background: A total of 68% of pre-school children with cleft palate have speech problems requiring speech therapy. There is a lack of access to regular targeted therapy. Parent training leads to positive outcomes in early communication skills in cleft palate and non-cleft speech disorders. Connected health has been used to address inadequate access to therapy, providing intervention to those who would not otherwise receive therapy., Aims: To evaluate the speech, activity and participation outcomes of Parent Led, Therapist Supervised, Articulation Therapy (PLAT) compared with routine speech therapy intervention in parent-child dyads., Methods & Procedures: A total of 44 children, aged 2.9-7.5 years, were included in a two-centre, two-phase randomized controlled trial. Informed consent and assent were obtained. Participants and speech and language therapists (SLTs) were unblinded to the groups. Parents, in the parent-trained group (n = 23), attended 2 days' training, received a detailed speech therapy programme, and undertook intervention over 12 weeks supported by the cleft specialist SLT using FaceTime and one face-to-face session. In the control arm (n = 21), parent-child dyads received six therapy sessions over 12 weeks with a research SLT, comparable with usual care. Speech recordings were undertaken pre- and post-intervention. Percent consonant correct (PCC) was analysed by external SLTs blinded to the time and group. Activity and participation were measured using the Intelligibility in Context Scale (ICS) and Focus on Outcomes for Children Under Six (FOCUS) questionnaire., Outcomes & Results: There was no evidence of an interaction between Time and Group or an overall statistical difference between groups for PCC scores. There was a statistically significant difference over time for both groups (words: p < 0.002; confidence interval (CI) = 9.38-16.27; d = 0.57; sentences: p < 0.002; CI = 16.04-25.97; d = 0.23). Effect sizes were medium for words and small for sentences. For intelligibility and participation, there was no evidence of an interaction between Time and Group or an overall statistical difference between groups. A statistically significant difference over time was found for intelligibility (F = 29.97, d.f. = 1, 42, p < 0.001, 95 % CI = 1.45-3.15 d = 0.46) and for participation (F = 14.19, d.f. = 1, 41, p < 0.001 95% CI = 7.63-25.03; d = 0.36) with FOCUS results indicating clinically meaningful (parent-led group) and significant (control group) change in participation., Conclusions & Implications: PLAT can be as effective as routine care in changing speech, activity and participation outcomes for children with cleft palate, when supported by a specialist cleft SLT using connected health. What this paper adds What is already known on this subject Over 50% of children with cleft palate require speech therapy. However, there is a lack of timely, accessible speech therapy services in the UK and Ireland. Previous studies have shown that parents can deliver therapy effectively, and that connected health can support the delivery of speech therapy. This study aims to provide evidence that parent-led therapy with the supervision of a specialist cleft therapist using FaceTime is effective. What this paper adds to existing knowledge This randomized controlled trial indicates that parents can be trained to deliver therapy for children with cleft palate speech disorders, under the supervision of an SLT. This approach results in improved speech, activity and participation outcomes similar to routine care. What are the potential or actual clinical implications of this work? This study indicates that both parent-led articulation therapy and routine care showed meaningful gains in speech, activity and participation, and that parent-led articulation therapy when supported by a cleft SLT using connected health could be an additional service delivery model for children with cleft palate speech disorders., (© 2020 Royal College of Speech and Language Therapists.)

Published
2020
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15. Polymeric membrane dressing for radiotherapy-induced skin reactions.

Author

Hegarty F and Wong M

Abstract

Post-radiotherapy treatment depends on how the skin within the treatment field has reacted during radiotherapy for cancer. Skin reactions can range from mild dull erythema and tightening of the skin to severe moist desquamation, which may result in wounds that can be painful and sloughy. It is estimated that approximately 87% of patients will experience a moderate-to-severe skin reaction. This article discusses an evaluation of the use of a polymeric membrane dressing (PolyMem®, Aspen Medical) in 23 patients with skin reactions following radiotherapy. A purpose-designed evaluation form was completed over a period of 4 weeks or until healed. Patients were asked to complete both qualitative descriptions and numerical scores of pain for symptoms and procedural pain. Skin healing, pain and sleep patterns were all evaluated, with additional qualitative input on the patient experience. Successful symptom management regarding pain, exudate control and patient comfort was documented in both clinical observations and patient diaries.

Published
2014
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16. 'Open Window': a randomized trial of the effect of new media art using a virtual window on quality of life in patients' experiencing stem cell transplantation.

Author

McCabe C, Roche D, Hegarty F, and McCann S

Subjects
Adolescent, Adult, Aged, Anxiety psychology, Depression psychology, Female, Hematologic Neoplasms surgery, Humans, Male, Middle Aged, Patient Isolation psychology, Prospective Studies, Quality of Life, Stress, Psychological psychology, Surveys and Questionnaires, Young Adult, Anxiety therapy, Art Therapy methods, Depression therapy, Hematologic Neoplasms psychology, Stem Cell Transplantation psychology, Stress, Psychological therapy, User-Computer Interface
Abstract

Objectives: To measure the psychological effect of an art intervention on hospitalized patients and explore benefits to their quality of life., Methods: We conducted a large prospective randomized trial between July 2006 and August 2009 of an art intervention, Open Window (OW), in patients undergoing stem cell transplantation for a hematological malignancy compared with a control group. The primary endpoint measured the effect of an art intervention on levels of anxiety, depression, and stress using the Hospital Anxiety and Depression Scale and the Distress Thermometer. The secondary endpoint measured the influence of OW on patients' experiences of stem cell transplantation using the OW survey and expectations questionnaires., Results: Of the 199 patients in the study, 96 were randomized to the intervention group and 103 to the control group. Participants in the intervention group had significantly reduced levels of anxiety on the day before transplant (p = 0.001), at day 7 (p = 0.041), and day 60 (p = 0.035). There was a significant reduction in depression before transplant (p = 0.022). Participants in the intervention group reported better experiences (p < 0.005). Qualitative data showed that those in the intervention group commented freely on their likes and dislikes about OW and how it made them feel., Conclusion: An art intervention, OW, had a positive influence on health-related quality of life and patients' experiences of having a stem cell transplant., (Copyright © 2011 John Wiley & Sons, Ltd.)

Published
2013
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17. The use of artificial neural networks to stratify the length of stay of cardiac patients based on preoperative and initial postoperative factors.

Author

Rowan M, Ryan T, Hegarty F, and O'Hare N

Subjects
Aged, Aged, 80 and over, Female, Humans, Intensive Care Units, Male, Middle Aged, Risk Assessment, Cardiac Surgical Procedures, Length of Stay statistics & numerical data, Neural Networks, Computer, Postoperative Care statistics & numerical data, Preoperative Care statistics & numerical data
Abstract

Background: The limitations of current prognostic models in identifying postoperative cardiac patients at risk of experiencing morbidity and subsequently an extended intensive care unit length of stay (ICU LOS) is well recognized. This coupled with the desire for risk stratification in order to prioritize medical intervention has lead to the need for the development of a system that can accurately predict individual patient outcome based on both preoperative and immediate postoperative clinical factors. The usefulness of artificial neural networks (ANNs) as an outcome prediction tool in the critical care environment has been previously demonstrated for medical intensive care unit (ICU) patients and it is the aim of this study to apply this methodology to postoperative cardiac patients., Methods: A review of contemporary literature revealed 15 preoperative risk factors and 17 operative and postoperative variables that have a determining effect on LOS. An integrated, multi-functional software package was developed to automate the ANN development process. The efficacy of the resultant individual ANNs as well as groupings or ensembles of ANNs were measured by calculating sensitivity and specificity estimates as well as the area under the receiver operating curve (AUC) when the ANN is applied to an independent test dataset., Results: The individual ANN with the highest discriminating ability produced an AUC of 0.819. The use of the ensembles of networks technique significantly improved the classification accuracy. Consolidating the output of three ANNs improved the AUC to 0.90., Conclusions: This study demonstrates the suitability of ANNs, in particular ensembles of ANNs, to outcome prediction tasks in postoperative cardiac patients.

Published
2007
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18. An automated ocular microtremor feature extraction using the Gabor thresholding technique.

Author

Al-Kalbani M, Collins N, Boyle G, Hegarty F, Foran T, Sheahan N, and Coakley D

Subjects
Algorithms, Artifacts, Humans, Signal Processing, Computer-Assisted, Eye Movements, Tremor
Abstract

Ocular Microtremor (OMT) is a very fine continuous eye movement which has potential in monitoring and identifying a number of clinical conditions. There is a need for improved analysis and processing techniques to extract useful, quantifiable parameters from the OMT signal. A number of papers have shown the clinical significance of looking at the 'bursts' and 'baseling' patterns of the OMT signal. Analysis to date relies on visual inspection alone. This paper introduces an automated approach to burst/baseline identification based on a time-varying filter using the Gabor transform.

Published
2007
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19. Design and implementation of an end tidal CO2 simulator for the evaluation of clinical gas analysers.

Author

Shakya K, Deegan C, Hegarty F, and Markham C

Subjects
Calibration, Equipment Design, Information Storage and Retrieval, Reproducibility of Results, Sensitivity and Specificity, Capnography instrumentation, Capnography methods, Carbon Dioxide analysis, Equipment Failure Analysis instrumentation, Equipment Failure Analysis methods, Microcomputers
Abstract

This paper presents a new technique to determine the dynamic and frequency response of capnographs using a custom built 'EtCO2 simulator system'. Capnographs are devices that use CO2 from a patients' expired breath to monitor the cardiopulmonary status during anaesthesia and mechanical ventilation. Capnographs at present are routinely calibrated via a static calibration method only. The dynamic response of the capnographs is not accounted for. The frequency and time response are important as they determine if capnographs can be used in high frequency and pediatric ventilation schemes. Experiments performed using the method described in this paper proved that old capnographs usually do not satisfy the manufacturer quoted specifications for time and frequency response. Therefore, a routine check for capnographs is recommended. The method can also be used to verify manufacturer quoted specifications. The EtCO2 simulator system, designed and constructed simulates human respiration cycle. The gas sources used are 5% CO2 and room air that can be switched alternatively. Both supplies are pressure regulated and connected through non-return valves to electric valves. The valves are microprocessor controlled and the on/off time is user defined allowing a wide range of waveforms to be simulated. The output from the simulator is delivered to capnograph. Capnograms are captured by digital video recording. The captured video in 'avi' file format is then converted into individual frames. These frames are converted into digital data through image processing in Matlab. The data obtained is subjected to extensive analysis to determine the frequency and time response of the respective capnograph.

Published
2005

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