1,158 results on '"Heffler, Enrico"'
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2. Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
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Scelo, Ghislaine, Tran, Trung N., Le, Tham T., Fagerås, Malin, Dorscheid, Delbert, Busby, John, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Beastall, Aaron, Bergeron, Celine, Bjermer, Leif, Bjerrum, Anne S., Cano-Rosales, Diana Jimena, Canonica, Giorgio Walter, Carter, Victoria, Charriot, Jeremy, Christoff, George C., Cosio, Borja G., Denton, Eve, Fernandez-Sanchez, Maria Jose, Fonseca, João A., Gibson, Peter G., Goh, Celine, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Katial, Rohit, Koh, Mariko S., Kuna, Piotr, Larenas-Linnemann, Désirée, Lehtimäki, Lauri, Mahboub, Bassam, Martin, Neil, Matsumoto, Hisako, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Patel, Pujan, Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin K., Sadatsafavi, Mohsen, Taillé, Camille, Torres-Duque, Carlos A., Tsai, Ming-Ju, Ulrik, Charlotte S., Upham, John W., von Bülow, Anna, Wang, Eileen, Wechsler, Michael E., and Price, David B.
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- 2024
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3. New evidence in food allergies treatment
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Ghelli, Chiara, Costanzo, Giovanni, Canonica, Giorgio Walter, Heffler, Enrico, and Paoletti, Giovanni
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- 2024
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4. Hereditary angioedema: current therapeutic management and future approaches
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Lamacchia, Donatella, Nappi, Emanuele, Marzio, Valentina, Locatelli, Francesca, Messina, Maria Rita, and Heffler, Enrico
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- 2024
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5. Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort
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Brussino, Luisa, Calabrese, Cecilia, Camiciottoli, Gianna, Carpagnano, Giovanna E., Centanni, Stefano, Corsico, Angelo G., Costantino, Maria T., Crimi, Claudia, D'adda, Alice, D'alo, Simona, D'amato, Maria, Del Giacco, Stefano, Di Marco, Fabiano, Facciolongo, Nicola C., Latorre, Manuela, Nettis, Eustachio, Nucera, Eleonora, Passalacqua, Giovanni, Pelaia, Girolamo, Pini, Laura, Ricciardi, Luisa, Richeldi, Luca, Ridolo, Erminia, Santus, Pierachille, Scichilone, Nicola, Scioscia, Giulia, Spadaro, Giuseppe, Spanevello, Antonio, Tarsia, Paolo, Caminati, Marco, Marcon, Alessandro, Vaia, Rachele, Senna, Gianenrico, Maule, Matteo, Marchetti, Pierpaolo, Miotti, Jessica, Argentino, Giuseppe, Blasi, Francesco, Canonica, Giorgio W., Heffler, Enrico M., Paggiaro, Pierluigi, Vianello, Andrea, and Guarnieri, Gabriella
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- 2024
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6. International Variation in Severe Exacerbation Rates in Patients With Severe Asthma
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Lee, Tae Yoon, Price, David, Yadav, Chandra Prakash, Roy, Rupsa, Lim, Laura Huey Mien, Wang, Eileen, Wechsler, Michael E., Jackson, David J., Busby, John, Heaney, Liam G., Pfeffer, Paul E., Mahboub, Bassam, Perng (Steve), Diahn-Warng, Cosio, Borja G., Perez-de-Llano, Luis, Al-Lehebi, Riyad, Larenas-Linnemann, Désirée, Al-Ahmad, Mona, Rhee, Chin Kook, Iwanaga, Takashi, Heffler, Enrico, Canonica, Giorgio Walter, Costello, Richard, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Porsbjerg, Celeste M., Torres-Duque, Carlos A., Christoff, George C., Popov, Todor A., Hew, Mark, Peters, Matthew, Gibson, Peter G., Maspero, Jorge, Bergeron, Celine, Cerda, Saraid, Contreras-Contreras, Elvia Angelica, Chen, Wenjia, and Sadatsafavi, Mohsen
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- 2024
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7. Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
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Perez-de-Llano, Luis, Scelo, Ghislaine, Canonica, G. Walter, Chen, Wenjia, Henley, William, Larenas-Linnemann, Désirée, Peters, Matthew J., Pfeffer, Paul E., Tran, Trung N., Ulrik, Charlotte Suppli, Popov, Todor A., Sadatsafavi, Mohsen, Hew, Mark, Máspero, Jorge, Gibson, Peter G., Christoff, George C., Fitzgerald, J. Mark, Torres-Duque, Carlos A., Porsbjerg, Celeste M., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Heffler, Enrico, Iwanaga, Takashi, Al-Ahmad, Mona, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Rhee, Chin Kook, Koh, Mariko Siyue, Cosio, Borja G., Perng (Steve), Diahn-Warng, Mahboub, Bassam, Menzies-Gow, Andrew N., Jackson, David J., Busby, John, Heaney, Liam G., Patel, Pujan H., Wang, Eileen, Wechsler, Michael E., Altraja, Alan, Lehtimäki, Lauri, Bourdin, Arnaud, Bjermer, Leif, Bulathsinhala, Lakmini, Carter, Victoria, Murray, Ruth, Beastall, Aaron, Denton, Eve, and Price, David B.
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- 2024
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8. Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
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Scelo, Ghislaine, Torres-Duque, Carlos A., Maspero, Jorge, Tran, Trung N., Murray, Ruth, Martin, Neil, Menzies-Gow, Andrew N., Hew, Mark, Peters, Matthew J., Gibson, Peter G., Christoff, George C., Popov, Todor A., Côté, Andréanne, Bergeron, Celine, Dorscheid, Delbert, FitzGerald, J. Mark, Chapman, Kenneth R., Boulet, Louis Philippe, Bhutani, Mohit, Sadatsafavi, Mohsen, Jiménez-Maldonado, Libardo, Duran-Silva, Mauricio, Rodriguez, Bellanid, Celis-Preciado, Carlos Andres, Cano-Rosales, Diana Jimena, Solarte, Ivan, Fernandez-Sanchez, Maria Jose, Parada-Tovar, Patricia, von Bülow, Anna, Bjerrum, Anne Sofie, Ulrik, Charlotte S., Assing, Karin Dahl, Rasmussen, Linda Makowska, Hansen, Susanne, Altraja, Alan, Bourdin, Arnaud, Taille, Camille, Charriot, Jeremy, Roche, Nicolas, Papaioannou, Andriana I., Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Salvi, Sundeep, Long, Deirdre, Mitchell, Patrick D., Costello, Richard, Sirena, Concetta, Cardini, Cristina, Heffler, Enrico, Puggioni, Francesca, Canonica, Giorgio Walter, Guida, Giuseppe, Iwanaga, Takashi, Al-Ahmad, Mona, Linnemann, Désirée Larenas, Garcia, Ulises, Kuna, Piotr, Fonseca, João A., Al-Lehebi, Riyad, Koh, Mariko Siyue, Rhee, Chin Kook, Cosio, Borja G., de Llano, Luis Perez, Perng (Steve), Diahn-Warng, Huang, Erick Wan-Chun, Wang, Hao-Chien, Tsai, Ming-Ju, Mahboub, Bassam, Salameh, Laila Ibraheem Jaber, Jackson, David, Busby, John, Heaney, Liam G., Pfeffer, Paul, Goddard, Amanda Grippen, Wang, Eileen, Hoyte, Flavia, Wechsler, Michael E., Chapman, Nicholas, Katial, Rohit, Carter, Victoria, Bulathsinhala, Lakmini, Eleangovan, Neva, Ariti, Con, Lyu, Juntao, Price, David B., and Porsbjerg, Celeste
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- 2024
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9. Sleep quality burden in chronic rhinosinusitis with nasal polyps and its modulation by dupilumab
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Ferri, Sebastian, Montagna, Carlo, Casini, Marta, Malvezzi, Luca, Pirola, Francesca, Russo, Elena, Racca, Francesca, Messina, Maria Rita, Puggioni, Francesca, Nappi, Emanuele, Costanzo, Giovanni, Del Moro, Lorenzo, Mercante, Giuseppe, Spriano, Giuseppe, Canonica, Giorgio Walter, Paoletti, Giovanni, and Heffler, Enrico
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- 2024
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10. Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus
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Canonica, Giorgio Walter, Blasi, Francesco, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Heffler, Enrico, Paggiaro, Pierluigi, Allegrini, Chiara, Antonelli, Andrea, Aruanno, Arianna, Bacci, Elena, Bagnasco, Diego, Beghè, Bianca, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Caiaffa, Maria Filomena, Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Caruso, Cristiano, Cavallini, Mirta, Chieco Bianchi, Fulvia, Conte, Maria Elisabetta, Corsico, Angelo Guido, Cosmi, Lorenzo, Costantino, Mariateresa, Costanzo, Giulia, Crivellaro, Mariaangiola, D'Alò, Simona, D'Amato, Mariella, Detoraki, Aikaterini, Di Proietto, Maria Carmela, Facciolongo, Nicola Cosimo, Ferri, Sebastian, Fierro, Vincenzo, Foschino, Maria Pia, Latorre, Manuela, Lombardi, Carlo, Macchia, Luigi, Milanese, Manlio, Montagni, Marcello, Parazzini, Elena Maria, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ridolo, Erminia, Rolo, Joyce, Scichilone, Nicola, Scioscia, Giulia, Senna, Gianenrico, Solidoro, Paolo, Varricchi, Gilda, Vianello, Andrea, Yacoub, Mona Rita, and Yang, Baoran
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- 2023
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11. Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control
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Cottini, Marcello, Bondi, Benedetta, Bagnasco, Diego, Braido, Fulvio, Passalacqua, Giovanni, Licini, Anita, Lombardi, Carlo, Berti, Alvise, Comberiati, Pasquale, Landi, Massimo, Heffler, Enrico, and Paoletti, Giovanni
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- 2023
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12. Advancing precision medicine in asthma: Evolution of treatment outcomes
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Canonica, Giorgio Walter, Varricchi, Gilda, Paoletti, Giovanni, Heffler, Enrico, and Virchow, Johann Christian
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- 2023
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13. Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry
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Chen, Wenjia, Tran, Trung N., Sadatsafavi, Mohsen, Murray, Ruth, Wong, Nigel Chong Boon, Ali, Nasloon, Ariti, Con, Bulathsinhala, Lakmini, Gil, Esther Garcia, FitzGerald, J. Mark, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne-Sofie, Bourdin, Arnaud, von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fonseca, João A., Gibson, Peter G., Yoo, Kwang-Ha, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri, Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Newell, Anthony, Sirena, Concetta, Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng (Steve), Diahn-Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Ra, Seung-Won, Wang, Eileen, Wechsler, Michael E., and Price, David B.
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- 2023
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14. Middle meatus nasal cytology compared to inferior turbinate cytology in non allergic rhinitis
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Bocciolini, Corso, Nappi, Emanuele, Giunta, Gianmarco, Paoletti, Giovanni, Malvezzi, Luca, Monti, Giulia, Macchi, Alberto, Amorosa, Luca, and Heffler, Enrico
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- 2023
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15. Nasal cytology as a reliable non-invasive procedure to phenotype patients with type 2 chronic rhinosinusitis with nasal polyps
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Paoletti, Giovanni, Malvezzi, Luca, Riccio, Anna Maria, Descalzi, Desideria, Pirola, Francesca, Russo, Elena, De Ferrari, Laura, Racca, Francesca, Ferri, Sebastian, Messina, Maria Rita, Puggioni, Francesca, Nappi, Emanuele, Bagnasco, Diego, Canevari, Frank Rikki, Grizzi, Fabio, Mercante, Giuseppe, Spriano, Giuseppe, Canonica, Giorgio Walter, and Heffler, Enrico
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- 2022
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16. The Role of Omalizumab in NSAID-Exacerbated Respiratory Disease: A Narrative Review
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Taniguchi, Masami, Heffler, Enrico, Olze, Heidi, White, Andrew, Côrte-Real, Joana, Olsson, Petter, and Lazarewicz, Slawomir
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- 2022
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17. COPD and biologic treatment: state of the art
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Ferri, Sebastian, Paoletti, Giovanni, Pelaia, Corrado, Heffler, Enrico, Canonica, Giorgio Walter, and Puggioni, Francesca
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- 2023
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18. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life
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Nettis, Eustachio, Brussino, Luisa, Patella, Vincenzo, Bonzano, Laura, Detoraki, Aikaterini, Di Leo, Elisabetta, Sirufo, Maria Maddalena, Caruso, Cristiano, Lodi Rizzini, Fabio, Conte, Mariaelisabetta, Yacoub, Mona-Rita, Triggiani, Massimo, Ridolo, Erminia, Macchia, Luigi, Rolla, Giovanni, Brancaccio, Raffaele, De Paulis, Amato, Spadaro, Giuseppe, Di Bona, Danilo, D’Uggento, Angela Maria, Ginaldi, Lia, Gaeta, Francesco, Nucera, Eleonora, Jaubashi, Kliljeda, Villalta, Danilo, Dagna, Lorenzo, Ciotta, Domenico, Pucciarini, Francesco, Bagnasco, Diego, Celi, Giorgio, Chieco Bianchi, Fulvia, Cosmi, Lorenzo, Costantino, Maria Teresa, Crivellaro, Maria Angiola, D’Alò, Simona, del Biondo, Pietro, Del Giacco, Stefano, Di Gioacchino, Mario, Di Pietro, Linda, Favero, Elisabetta, Gangemi, Sebastiano, Guarnieri, Gabriella, Heffler, Enrico, Leto Barone, Maria Stefania, Lombardo, Carla, Losa, Francesca, Matucci, Andrea, Minciullo, Paola Lucia, Parronchi, Paola, Passalacqua, Giovanni, Pucci, Stefano, Rossi, Oliviero, Salvati, Lorenzo, Schiappoli, Michele, Senna, Gianenrico, Vianello, Andrea, Vultaggio, Alessandra, Baoran, Yang, Incorvaia, Cristoforo, and Canonica, Giorgio Walter
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- 2022
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19. Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma
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Porsbjerg, Celeste M., Menzies-Gow, Andrew N., Tran, Trung N., Murray, Ruth B., Unni, Bindhu, Audrey Ang, Shi Ling, Alacqua, Marianna, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Belevskiy, Andrey S., Björnsdóttir, Unnur S., Bourdin, Arnaud, Busby, John, Canonica, G. Walter, Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Fonseca, João A., Hansen, Susanne, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jackson, David J., Kocks, Janwillem W.H., Kallieri, Maria, Bruce Ko, Hsin-Kuo, Koh, Mariko Siyue, Larenas-Linnemann, Désirée, Lehtimäki, Lauri A., Loukides, Stelios, Lugogo, Njira, Maspero, Jorge, Papaioannou, Andriana I., Perez-de-Llano, Luis, Pitrez, Paulo Márcio, Popov, Todor A., Rasmussen, Linda M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Schmid, Johannes, Siddiqui, Salman, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte, Upham, John W., Wang, Eileen, Wechsler, Michael E., Bulathsinhala, Lakmini, Carter, Victoria, Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Rowlands, Mari-Anne, Price, David B., and van Boven, Job F.M.
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- 2022
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20. Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils.
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Buchheit, Kathleen M., Shaw, Dominick, Chupp, Geoffrey, Lehtimaki, Lauri, Heffler, Enrico, Finney‐Hayward, Tricia, Zangrilli, James, Kwiatek, Justin, Siddiqui, Salman, Roufosse, Florence, Thamboo, Andrew, West, Nicholas, Vichiendilokkul, Anna, Hellings, Peter W., Peters, Anju, and Howarth, Peter H.
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REGULATORY T cells ,INNATE lymphoid cells ,EPITHELIAL cells ,EOSINOPHILS ,PLASMA cells - Abstract
Interleukin (IL)‐5 is the key cytokine in the maturation, activation, proliferation, migration and survival of eosinophils, which are key effector cells in many upper and lower airway diseases. Through its effects on eosinophils, IL‐5 indirectly contributes to various pathophysiological processes including tissue damage, repair and remodelling. Understanding the importance of IL‐5 in eosinophil‐associated diseases led to the development of anti‐IL‐5 therapies, which provide clinical benefits across a range of conditions. However, recent evidence suggests that eosinophil‐depletion alone may not account for all of the therapeutic effects of anti‐IL‐5 therapy and that IL‐5 may also contribute to disease independently of its effects on eosinophils. Indeed, evidence from ex vivo studies and targeted therapy in vivo demonstrates that IL‐5 and its inhibition affects a much broader range of cells beyond eosinophils, including epithelial cells, plasma cells, mast cells, basophils, neutrophils, type 2 innate lymphoid cells, T regulatory cells and fibroblasts. This review will provide an update on the evidence supporting the breadth of IL‐5 biology relevant to disease pathogenesis beyond eosinophil‐associated inflammation, where there is a need for additional insight, and the clinical implications of a more central role of IL‐5 in type 2 inflammation. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process
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Mansur, Adel, Detoraki, Aikaterini, Altraja, Alan, James, Alan, Nanzer-Kelly, Alexandra, Côté, Andréanne, Menzies-Gow, Andrew, Papaioannou, Andriana, Cheffins, Anne-Maree, Bourdin, Arnaud, Mahboub, Bassam, Lipworth, Brian, Celis-Preciado, Carlos Andrés, Torres-Duque, Carlos, Bucca, Caterina, Porsbjerg, Celeste, Ulrik, Charlotte, Corrigan, Chris, Taube, Christian, Farah, Claude, Katelaris, Constance, Langton, David, Ryan, Dermot, Larenas-Linnemann, Désirée, Zervas, Eleftherios, Heffler, Enrico, Hoyte, Flavia, Puggioni, Francesca, Christoff, George, Canonica, Giorgio Walter, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Katsoulotos, Gregory, Brusselle, Guy, Rupani, Hitashi, Jersmann, Hubertus, Clifton, Ian, Dhariwal, Jaideep, Fingleton, James, Duke, Jane, Rimmer, Janet, Douglass, Jo, Fonseca, João, van Boven, Job, Corless, John, Harrington, John, Maspero, Jorge, Miguel, José Luis, Pipatvech, Kanok, Kenny, Karrinda, Chapman, Kenneth, Kostikas, Konstantinos, Lehtimäki, Lauri, Chung, Li Ping, Heaney, Liam, Hang, Liang-Wen, Boulet, Louis-Philippe, Perez-de-Llano, Luis, Ricciardi, Luisa, Idrees, Majdy, Milanese, Manlio, Conte, Maria Elisabetta, Costantino, Maria Teresa, Siyue, Mariko Koh, Fitzgerald, Mark, Hew, Mark, Peters, Matthew, Tsai, Ming-Ju, Patel, Mitesh, Khan, Mohammad Hashim, Sadatsafavi, Mohsen, Al-Ahmad, Mona, Yacoub, Mona-Rita, De Gennaro, Mónica, Radhakrishna, Naghmeh, Hanania, Nicola Alexander, Papadopoulos, Nikolaos, Lugogo, Njira, Linaker, Norma, Crimi, Nunzio, Dennison, Paddy, Nair, Parameswaran, Mitchell, Patrick David, O’Byrne, Paul, Pfeffer, Paul, Kauppi, Paula, Hughes, Pauline, Middleton, Peter, Wark, Peter, Bardin, Philip, Fu, Pin-Kuei, Akuthota, Praveen, Chaudhuri, Rekha, Campos, Ricardo, Al-Lehebi, Riyard, Parente, Roberta, Francisco, Rovira, Wenzel, Sally, Pierachille, Santus, Pawar, Shrikant, Loukides, Stelios, Fowler, Stephen, Mackenzie, Tara, Brown, Thomas, Lee Tan, Tze, Björnsdóttir, Unnur, McDonald, Vanessa, Lawriwskyj, Veronica, Backer, Vibeke, Vasileva, Violina, Chien, Ying-Chun, Harrington, Zinta, Upham, John W., Le Lievre, Chantal, Jackson, David J., Masoli, Matthew, Wechsler, Michael E., and Price, David B.
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- 2021
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22. Severe asthma: One disease and multiple definitions
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Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni
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- 2021
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23. Indirect Treatment Comparison of Biologics in Chronic Rhinosinusitis with Nasal Polyps
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Peters, Anju T., Han, Joseph K., Hellings, Peter, Heffler, Enrico, Gevaert, Philippe, Bachert, Claus, Xu, Yingxin, Chuang, Chien-Chia, Neupane, Binod, Msihid, Jérôme, Mannent, Leda P., Guyot, Patricia, and Kamat, Siddhesh
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- 2021
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24. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial
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Bazzalo, Ignacio J., Casas, Marcelo M., Nuñez, Sebastián A., Pere, Yael, Ibarrola, Carlos M., Solis Aramayo, Marco A., Cuesta, Maria C., Duarte, Andrea E., Gutierrez Fernandez, Pablo M., Iannantuono, Maria A., Miyazaki, Erica A., Silvio, Javier P., Scublinsky, Dario G., Bales, Alessandra, Catarino, Daniela, Fiss, Elie, Mohrbacher, Sara, Sato, Victor, Baylao, Antonio, Cavalcante, Adilson, Correa, Francini, de Andrade, Celso A., Furtado, Juvencio, Ribeiro Filho, Nelson, Telles, Valéria, Trevelin, Leopoldo T., Vipich, Ricardo, Boldo, Rodrigo, Borges, Paula, Lobo, Suzana, Luckemeyer, Graziela, Machado, Luana, Alves, Maysa B., Iglessias, Ana C., Lago, Marianna M., Santos, Daniel W., Chapdelaine, Hugo, Falcone, Emilia L., Jamal, Rahima, Luong, Me-Linh, Durand, Madeleine, Doucet, Stephane, Carrier, François-Martin, Coburn, Bryan A., Del Sorbo, Lorenzo, Walmsley, Sharon L., Belga, Sara, Chen, Luke Y., Mah, Allison D., Steiner, Theodore, Wright, Alissa J., Hajek, J., Adhikari, Neill, Fowler, Robert A., Daneman, Nick, Khwaja, Kosar A., Shahin, Jason, Gonzalez, Carolina, Silva, Rafael, Lindh, Marcelo, Maluenda, Gabriel, Fernandez, Patricia, Oyonarte, Maite, Lasso, Martin, Boyer, Alexandre, Bronnimann, Didier, Bui, Hoang-Nam, Cazanave, Charles, Chaussade, Helene, Desclaux, Arnaud, Ducours, Mailys, Duvignaud, Alexandre, Malvy, Denis, Martin, Lisa, Neau, Didier, Nguyen, Duc, Pistone, Thierry, Soubrane-Wirth, Gaetane, Leitao, Julie, Allavena, Clotilde, Biron, Charlotte, Bouchez, Sabelline, Gaborit, Benjamin, Gregoire, Antoine, Le Turnier, Paul, Lecompte, Anne-Sophie, Lecomte, Raphael, Lefebvre, Maeva, Raffi, Francois, Boutoille, David, Morineau, Pascale H., Guéry, Romain, Chatelus, Emmanuel, Dumoussaud, Nathalie, Felten, Renaud, Luca, Florina, Goichot, Bernard, Schneider, Francis, Taquet, Marie-Caroline, Groh, Matthieu, Roumier, Mathilde, Neuville, Mathilde, Bachelard, Antoine, Isernia, Valentina, Lescure, F-Xavier, Phung, Bao-Chau, Rachline, Anne, Sautereau, Aurelie, Vallois, Dorothee, Bleher, Yves, Boucher, Delphine, Coudon, Clémentine, Esnault, Jean, Guimard, Thomas, Leautez-Nainville, Sophie, Merrien, Dominique, Morrier, Marine, Motte-Vincent, Pauline, Gabeff, Romain, Leclerc, Hélène, Cozic, Céline, Decours, Romain, Février, Ronan, Colin, Gwenhael, Abgrall, Sophie, Vignes, Dorothee, Sterpu, Raluca, Kuellmar, Mira, Meersch-Dini, Melanie, Weiss, Raphael, Zarbock, Alexander, Antony, Christiane, Berger, Marc, Brenner, Thorsten, Taube, Christian, Herbstreit, Frank, Dolff, Sebastian, Konik, Margarethe, Schmidt, Karsten, Zettler, Markus, Witzke, Oliver, Boell, Boris, Garcia Borrega, Jorge, Koehler, Philipp, Zander, Thomas, Dusse, Fabian, Al-Sawaf, Othman, Köhler, Philipp, Eichenauer, Dennis, Kochanek, Matthias, Shimabukuro-Vornhagen, Alexander, Mellinghoff, Sibylle, Claßen, Annika, Heger, Jan-Michel, Meyer-Schwickerath, Charlotte, Liedgens, Paul, Heindel, Katrin, Belkin, Ana, Biber, Asaf, Gilboa, Mayan, Levy, Itzchak, Litachevsky, Vladislav, Rahav, Galia, Finesod Wiedner, Anat, Zilberman-Daniels, Tal, Oster, Yonatan, Strahilevitz, Jacob, Sviri, Sigal, Baldissera, Elena M., Campochiaro, Corrado, Cavalli, Giulio, Dagna, Lorenzo, De Luca, Giacomo, Della Torre, Emanuel, Tomelleri, Alessandro, Bernasconi De Luca, Davide, Capetti, Amedeo F., Coen, Massimo, Cossu, Maria V., Galli, Massimo, Giacomelli, Andrea, Gubertini, Guido A., Rusconi, Stefano, Burastero, Giulia J., Digaetano, Margherita, Guaraldi, Giovanni, Meschiari, Marianna, Mussini, Cristina, Puzzolante, Cinzia, Volpi, Sara, Aiello, Marina, Ariani, Alarico, Chetta, Alfredo A., Frizzelli, Annalisa, Ticinesi, Andrea, Tuttolomondo, Domenico, Aliberti, Stefano, Blasi, Francesco B., Di Pasquale, Marta F., Misuraca, Sofia, Pilocane, Tommaso, Simonetta, Edoardo, Aghelmo, Alessio M., Angelini, Claudio, Brunetta, Enrico, Canonica, Giorgio W., Ciccarelli, Michele, Dal Farra, Sara, De Santis, Maria, Ferri, Sebastian, Folci, Marco, Guidelli, Giacomo M., Heffler, Enrico M., Loiacono, Ferdinando, Malipiero, Giacomo, Paoletti, Giovanni, Pedale, Rosa, Puggioni, Francesca A., Racca, Francesca, Zumbo, Aurora, Satou, Morihiko, Honda, Hitoshi, Lisun, Tatyana, Protsenko, Denis, Rubtsov, Nikolay, Beloglazova, Irina, Fomina, Daria, Lysenko, Mariana, Serdotetskova, Sofia, Firstov, Vitali, Gordeev, Ivan, Kokorin, Ilia, Komissarova, Ksenia, Lapochkina, Nina, Luchinkina, Elena, Malimon, Valentin, Mamedguseyinova, Sevinch, Polubatonova, Ksenia, Suvorova, Natalia, Arribas, Jose, Borobia Perez, Alberto M., de la Calle Prieto, Fernando, Figueira, Juan Carlos, Motejano Sanchez, Rocio, Mora-Rillo, Marta, Prados Sanchez, Concepcion, Queiruga Parada, Javier, Fernandez Arnalich, Francisco, Guerro Barrientos, Maria, Bendala Estrada, Alejandro, Caballero Marcos, Aranzazu, Garcia Leoni, Maria E., García-Martínez, Rita, Collado, Ana María, Munoz Garcia, Patricia, Torres do Rego, Ana, Villalba García, María V., Burrillo, Almudena, Valerio Minero, Maricela, Gijon Vidaurreta, Paloma, Infante Herrero, Sonsoles, Velilla, Elena, Machado, Marina, Olmedo, Maria, Pinilla, Blanca, Almirante Gragera, Benito, Cañas Ruano, Maria de la Esperanza, Contreras Medina, Sofia, Cortés Herrera, Alejandro, Falcó Ferrer, Vicenç, Ferrer Roca, Ricard, Nuvials Casals, Xavier, Ribera Pascuet, Esteve, Suanzes Diez, Paula, Rebollo Castro, Pedro, Garcia Alcaide, Felipe, Soriano, Alejandro, Oliver Caldes, Aina, González Cordón, Ana, Cardozo, Celia, De la Mora Cañizo, Lorena, Pena López, Romina, Chamorro, Sandra, Crespillo-Andujar, Clara, Escudero Sanchez, Rosa, Fortún-Abete, Jesús, Monge-Maillo, Begoña, Moreno Zamora, Ana, Norman, Francesca, Sanchez Conde, Matilde, Serrano Villar, Sergio, Vizcarra, Pilar, Lescure, François-Xavier, Fowler, Robert A, Lazar, Jennifer Sloane, Shi, Genming, Wung, Peter, Patel, Naimish, and Hagino, Owen
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- 2021
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25. Successful SARS-CoV-2 vaccine allergy risk-management: The experience of a large Italian University Hospital
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Paoletti, Giovanni, Racca, Francesca, Piona, Alessandra, Melone, Giulio, Merigo, Morena, Puggioni, Francesca, Ferri, Sebastian, Azzolini, Elena, Lagioia, Michele, Lamacchia, Donatella, Cataldo, Giuseppe, Cecconi, Maurizio, Canonica, Giorgio Walter, and Heffler, Enrico
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- 2021
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26. BASELINE CHARACTERISTICS AND COEXISTING TYPE 2 INFLAMMATORY DISEASES OF PATIENTS WITH ASTHMA INITIATING DUPILUMAB IN A REAL-WORLD SETTING: THE RAPID REGISTRY
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LUGOGO, NJIRA L, PETERS, ANJU T, CÔTÉ, ANDRÉANNE, HILBERG, OLE, HEFFLER, ENRICO, MUNOZ, XAVIER, VINGE, INES, MANSUR, ADEL, NAGASE, HIROYUKI, SHAO, LIYANG, GALL, REBECCA, DE PRADO GOMEZ, LUCIA, JACOB-NARA, JUBY A, SACKS, HARRY, ROWE, PAUL J, DENIZ, YAMO, and BOURDIN, ARNAUD
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- 2024
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27. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life
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Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni
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- 2021
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28. Baseline Systemic Oral Corticosteroid Use in Patients with Asthma Initiating Dupilumab Treatment in the Real World: From the RAPID Global Registry
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Lugogo,Nijra, Heffler,Enrico, Plaza,Vicente, Hilberg,Ole, Xia,Changming, Nash,Scott, Pandit,Nami, Jacob-Nara,Juby, Sacks,Harry, Rowe,Paul, Deniz,Yamo, Hardin,Megan, Soler,Xavier, Lugogo,Nijra, Heffler,Enrico, Plaza,Vicente, Hilberg,Ole, Xia,Changming, Nash,Scott, Pandit,Nami, Jacob-Nara,Juby, Sacks,Harry, Rowe,Paul, Deniz,Yamo, Hardin,Megan, and Soler,Xavier
- Abstract
Nijra L Lugogo,1 Enrico Heffler,2,3 Vicente Plaza,4 Ole Hilberg,5 Changming Xia,6 Scott Nash,6 Nami Pandit,7 Juby A Jacob-Nara,7 Harry J Sacks,6 Paul J Rowe,7 Yamo Deniz,6 Megan Hardin,8 Xavier Soler6 1University of Michigan Medical School, Ann Arbor, MI, USA; 2IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; 3Humanitas University, Pieve Emanuele, Milan, Italy; 4Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 5Lillebaelt Hospital, Vejle, Denmark; 6Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA; 7Sanofi, Bridgewater, NJ, USA; 8Sanofi, Cambridge, MA, USACorrespondence: Nijra L Lugogo, University of Michigan Medical School, 300 North Ingalls St, Suite 2C40, Ann Arbor, MI, 48109, USA, Email nlugogo@med.umich.edu
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- 2024
29. Real-world biologics response and super-response in the International Severe Asthma Registry cohort
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Denton, Eve, Hew, Mark, Peters, Matthew J., Upham, John W., Bulathsinhala, Lakmini, Tran, Trung N., Martin, Neil, Bergeron, Celine, Al-Ahmad, Mona, Altraja, Alan, Larenas-Linnemann, Desiree, Murray, Ruth, Celis-Preciado, Carlos Andres, Al-Lehebi, Riyad, Belhassen, Manon, Bhutani, Mohit, Bosnic-Anticevich, Sinthia Z., Bourdin, Arnaud, Brusselle, Guy G., Busby, John, Canonica, Giorgio Walter, Heffler, Enrico, Chapman, Kenneth R., Charriot, Jeremy, Christoff, George C., Chung, Li Ping, Cosio, Borja G., Cote, Andreanne, Costello, Richard W., Cushen, Breda, Fingleton, James, Fonseca, Joao A., Gibson, Peter G., Heaney, Liam G., Huang, Erick Wan-Chun, Iwanaga, Takashi, Jackson, David J., Koh, Mariko Siyue, Lehtimaki, Lauri, Maspero, Jorge, Mahboub, Bassam, Menzies-Gow, Andrew N., Mitchell, Patrick D., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng, Diahn-Warng, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Denton, Eve, Hew, Mark, Peters, Matthew J., Upham, John W., Bulathsinhala, Lakmini, Tran, Trung N., Martin, Neil, Bergeron, Celine, Al-Ahmad, Mona, Altraja, Alan, Larenas-Linnemann, Desiree, Murray, Ruth, Celis-Preciado, Carlos Andres, Al-Lehebi, Riyad, Belhassen, Manon, Bhutani, Mohit, Bosnic-Anticevich, Sinthia Z., Bourdin, Arnaud, Brusselle, Guy G., Busby, John, Canonica, Giorgio Walter, Heffler, Enrico, Chapman, Kenneth R., Charriot, Jeremy, Christoff, George C., Chung, Li Ping, Cosio, Borja G., Cote, Andreanne, Costello, Richard W., Cushen, Breda, Fingleton, James, Fonseca, Joao A., Gibson, Peter G., Heaney, Liam G., Huang, Erick Wan-Chun, Iwanaga, Takashi, Jackson, David J., Koh, Mariko Siyue, Lehtimaki, Lauri, Maspero, Jorge, Mahboub, Bassam, Menzies-Gow, Andrew N., Mitchell, Patrick D., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Perez-de-Llano, Luis, Perng, Diahn-Warng, Pfeffer, Paul E., Popov, Todor A., and Porsbjerg, Celeste M.
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Background: Biologic asthma therapies reduce exacerbations and long-term oral corticosteroids (LTOCS) use in randomized controlled trials (RCTs); however, there are limited data on outcomes among patients ineligible for RCTs. Hence, we investigated responsiveness to biologics in a real-world population of adults with severe asthma. Methods: Adults in the International Severe Asthma Registry (ISAR) with ≥24 weeks of follow-up were grouped into those who did, or did not, initiate biologics (anti-IgE, anti-IL5/IL5R, anti-IL4/13). Treatment responses were examined across four domains: forced expiratory volume in 1 second (FEV 1) increase by ≥100 mL, improved asthma control, annualized exacerbation rate (AER) reduction ≥50%, and any LTOCS dose reduction. Super-response criteria were: FEV 1 increase by ≥500 mL, new well-controlled asthma, no exacerbations, and LTOCS cessation or tapering to ≤5 mg/day. Results: 5.3% of ISAR patients met basic RCT inclusion criteria; 2116/8451 started biologics. Biologic initiators had worse baseline impairment than non-initiators, despite having similar biomarker levels. Half or more of initiators had treatment responses: 59% AER reduction, 54% FEV 1 increase, 49% improved control, 49% reduced LTOCS, of which 32%, 19%, 30%, and 39%, respectively, were super-responses. Responses/super-responses were more frequent in biologic initiators than in non-initiators; nevertheless, ~40–50% of initiators did not meet response criteria. Conclusions: Most patients with severe asthma are ineligible for RCTs of biologic therapies. Biologics are initiated in patients who have worse baseline impairments than non-initiators despite similar biomarker levels. Although biologic initiators exhibited clinical responses and super-responses in all outcome domains, 40–50% did not meet the response criteria.
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- 2024
30. Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
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Porsbjerg, Celeste M., Townend, John, Bergeron, Celine, Christoff, George C., Katsoulotos, Gregory P., Larenas-Linnemann, Desiree, Tran, Trung N., Al-Lehebi, Riyad, Bosnic-Anticevich, Sinthia Z., Busby, John, Hew, Mark, Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Pfeffer, Paul E., Popov, Todor A., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tsai, Ming-Ju, Ulrik, Charlotte Suppli, Al-Ahmad, Mona, Altraja, Alan, Beastall, Aaron, Bulathsinhala, Lakmini, Carter, Victoria, Cosio, Borja G., Fletton, Kirsty, Hansen, Susanne, Heaney, Liam G., Hubbard, Richard B., Kuna, Piotr, Murray, Ruth B., Nagano, Tatsuya, Pini, Laura, Rosales, Diana Jimena Cano, Schleich, Florence, Wechsler, Michael E., Amaral, Rita, Bourdin, Arnaud, Brusselle, Guy G., Chen, Wenjia, Chung, Li Ping, Denton, Eve, Fonseca, Joao A., Hoyte, Flavia, Jackson, David J., Katial, Rohit, Kirenga, Bruce J., Koh, Mariko Siyue, Lawkiedraj, Agnieszka, Lehtimaki, Lauri, Liew, Mei Fong, Mahboub, Bassam, Martin, Neil, Menzies-Gow, Andrew N., Pang, Pee Hwee, Papaioannou, Andriana I., Patel, Pujan H., Perez-De-Llano, Luis, Peters, Matthew J., Ricciardi, Luisa, Rodriguez-Caceres, Bellanid, Solarte, Ivan, Tay, Tunn Ren, Torres-Duque, Carlos A., Wang, Eileen, Zappa, Martina, Abisheganaden, John, Assing, Karin Dahl, Costello, Richard W., Gibson, Peter G., Heffler, Enrico, Maspero, Jorge, Nicola, Stefania, Steve, Diahn-Warng Perng, Puggioni, Francesca, Salvi, Sundeep, Sheu, Chau-Chyun, Sirena, Concetta, Taille, Camille, Tan, Tze Lee, Bjermer, Leif, Canonica, Giorgio Walter, Iwanaga, Takashi, Jimenez-Maldonado, Libardo, Taube, Christian, Brussino, Luisa, Price, David B., Porsbjerg, Celeste M., Townend, John, Bergeron, Celine, Christoff, George C., Katsoulotos, Gregory P., Larenas-Linnemann, Desiree, Tran, Trung N., Al-Lehebi, Riyad, Bosnic-Anticevich, Sinthia Z., Busby, John, Hew, Mark, Kostikas, Konstantinos, Papadopoulos, Nikolaos G., Pfeffer, Paul E., Popov, Todor A., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tsai, Ming-Ju, Ulrik, Charlotte Suppli, Al-Ahmad, Mona, Altraja, Alan, Beastall, Aaron, Bulathsinhala, Lakmini, Carter, Victoria, Cosio, Borja G., Fletton, Kirsty, Hansen, Susanne, Heaney, Liam G., Hubbard, Richard B., Kuna, Piotr, Murray, Ruth B., Nagano, Tatsuya, Pini, Laura, Rosales, Diana Jimena Cano, Schleich, Florence, Wechsler, Michael E., Amaral, Rita, Bourdin, Arnaud, Brusselle, Guy G., Chen, Wenjia, Chung, Li Ping, Denton, Eve, Fonseca, Joao A., Hoyte, Flavia, Jackson, David J., Katial, Rohit, Kirenga, Bruce J., Koh, Mariko Siyue, Lawkiedraj, Agnieszka, Lehtimaki, Lauri, Liew, Mei Fong, Mahboub, Bassam, Martin, Neil, Menzies-Gow, Andrew N., Pang, Pee Hwee, Papaioannou, Andriana I., Patel, Pujan H., Perez-De-Llano, Luis, Peters, Matthew J., Ricciardi, Luisa, Rodriguez-Caceres, Bellanid, Solarte, Ivan, Tay, Tunn Ren, Torres-Duque, Carlos A., Wang, Eileen, Zappa, Martina, Abisheganaden, John, Assing, Karin Dahl, Costello, Richard W., Gibson, Peter G., Heffler, Enrico, Maspero, Jorge, Nicola, Stefania, Steve, Diahn-Warng Perng, Puggioni, Francesca, Salvi, Sundeep, Sheu, Chau-Chyun, Sirena, Concetta, Taille, Camille, Tan, Tze Lee, Bjermer, Leif, Canonica, Giorgio Walter, Iwanaga, Takashi, Jimenez-Maldonado, Libardo, Taube, Christian, Brussino, Luisa, and Price, David B.
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Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life. Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers. Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV1 for both anti-IgE and anti-IL5/5R, with a trend for antiI-IL4R alpha. Mean FEV1 improved by 27-178 mL post-anti-IgE as pre-biologic BEC increased (250 to 1000 cells/mu L), and by 43-216 mL and 129-250 mL post-anti-IL5/5R and - anti- IL4R alpha, respectively along the same BEC gradient. Corresponding improvements along a FeNO gradient (25-100 ppb) were 41-274 mL, 69-207 mL and 148-224 mL for anti-IgE, anti-IL5/5R, and anti-IL4R alpha, respectively. Higher baseline BEC was also associated with lower probability of uncontrolled asthma (OR 0.392; p=0.001) post-biologic for anti-IL5/5R. Pre-biologic IgE was a poor predictor of subsequent pre-to-post-biologic change for
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- 2024
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31. Clinical remission in severe asthma: lights and shadows on an ambitious goal.
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Pelaia, Corrado, Zannoni, Eleonora, Paoletti, Giovanni, Marzio, Valentina, Heffler, Enrico, and Carrón-Herrero, Alejandra
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- 2024
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32. Eosinophils, Eosinophilic Gastrointestinal Diseases, and Inflammatory Bowel Disease: A Critical Review.
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Migliorisi, Giulia, Mastrorocco, Elisabetta, Dal Buono, Arianna, Gabbiadini, Roberto, Pellegatta, Gaia, Spaggiari, Paola, Racca, Francesca, Heffler, Enrico, Savarino, Edoardo Vincenzo, Bezzio, Cristina, Repici, Alessandro, and Armuzzi, Alessandro
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INFLAMMATORY bowel diseases ,EOSINOPHILIC esophagitis ,GASTROINTESTINAL diseases ,DIETARY patterns ,EOSINOPHILS - Abstract
Background/Objectives: Inflammatory bowel disease (IBD) and eosinophilic gastrointestinal diseases (EGIDs) are complex, multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. Their epidemiology, particularly for eosinophilic esophagitis (EoE), is increasing worldwide, with a rise in the co-diagnosis of IBD and EGIDs. Both disorders share common risk factors, such as early exposure to antibiotics or specific dietary habits. Moreover, from a molecular perspective, eosinophilic infiltration is crucial in the diagnosis of eosinophilic disorders, and it also plays a pivotal role in IBD histological diagnosis. Indeed, recent evidence highlights the significant role of eosinophils in the health of the intestinal mucosal barrier and as mediators between innate and acquired immunity, even indicating a potential role in IBD pathogenesis. This narrative review aims to summarize the current evidence regarding the common clinical and molecular aspects of EGIDs and IBD and the current state of knowledge regarding overlap conditions and their pathogenesis. Methods: Pubmed was searched until May 2023 to assess relevant studies describing the epidemiology, pathophysiology, and therapy of EGIDs in IBD. Results: The immune pathways and mechanisms underlying both EGIDs and IBD remain partially known. An improved understanding of the role of eosinophils in overlapping conditions could lead to enhanced diagnostic precision, the development of more effective future therapeutic strategies, and a more accurate prediction of patient response. Consequently, the identification of red flags indicative of an eosinophilic disorder in IBD patients is of paramount importance and must be evaluated on a case-by-case basis. [ABSTRACT FROM AUTHOR]
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- 2024
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33. Baseline Systemic Oral Corticosteroid Use in Patients with Asthma Initiating Dupilumab Treatment in the Real World: From the RAPID Global Registry.
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Lugogo, Nijra L, Heffler, Enrico, Plaza, Vicente, Hilberg, Ole, Xia, Changming, Nash, Scott, Pandit, Nami, Jacob-Nara, Juby A, Sacks, Harry J, Rowe, Paul J, Deniz, Yamo, Hardin, Megan, and Soler, Xavier
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FORCED expiratory volume ,ASTHMATICS ,EXPIRATORY flow ,EMPLOYEE ownership ,ADRENERGIC beta agonists - Abstract
This article discusses the baseline characteristics of patients with asthma who are initiating treatment with the medication dupilumab in a real-world setting. The study is part of the Registry of Asthma Patients Initiating DUPIXENT (RAPID), which aims to collect information on the use and effectiveness of dupilumab for asthma in a clinical setting. The analysis found that 25% of the patients had used oral corticosteroids (OCS) in the three months prior to enrollment or were currently using them. Patients with and without a history of OCS use had similarly impaired lung function, indicating a high treatment need. The findings suggest that many patients in the real-world asthma population require additional therapy to reduce OCS use. [Extracted from the article]
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- 2024
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34. Radiological Versus Clinical 1‐Year Outcomes of Dupilumab in Refractory CRSwNP: A Real‐Life Study.
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Giombi, Francesco, Pace, Gian Marco, Nappi, Emanuele, Giunta, Gianmarco, Muci, Giovanna, Pirola, Francesca, Ferreli, Fabio, Heffler, Enrico, Paoletti, Giovanni, Giannitto, Caterina, Mercante, Giuseppe, Francone, Marco, Spriano, Giuseppe, Canonica, Giorgio Walter, and Malvezzi, Luca
- Abstract
Objective: To provide real‐life evidence on long‐term radiological changes in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) treated with dupilumab, and to assess possible differences between radiological and clinical results in terms of endoscopic findings and Patient‐Reported‐Outcomes (PROs). Methods: Consecutive patients treated with dupilumab for recalcitrant CRSwNP were required to undergo CT scan at baseline (T0) and after 12 (T1) since first administration. A group of patients also performed CT scan at 52 weeks (T2) to assess long‐term outcomes. At each timepoint, patients underwent nasal endoscopy, assessment of Nasal‐Polyp‐Score (NPS), Lund‐Kennedy‐Score (LKS), and had to fill in the 22‐item Sinonasal‐Outcome‐Test (SNOT‐22) and Visual‐Analogue‐Scales (VAS) for sinonasal symptoms. Results: In fifty‐three included patients, from T0 to T1 we detected a significant reduction in mean Lund‐Mackay score (LM), PROs (SNOT‐22, VAS) and endoscopic (NPS, LKS) scores (p < 0.05). In the subset of patients that reached T2 (n = 30), compared to T1, we observed a further significant decrease in mean LM, SNOT‐22, VAS, and NPS scores, but not in LKS (p = 0.420). At T1, the highest improvement was observed in PROs (SNOT‐22: 56.26%), and polyp size (NPS: 49.83%). Conversely, between T1 and T2, sinus opacification was shown to be the most improved outcome (LM: 36.86%). Conclusions: Our experience showed that poorly controlled CRSwNP patients treated with dupilumab experienced significant improvement in radiologic, endoscopic and clinical disease severity. While in the initial 3 months, PROs garnered attention for showing earlier effectiveness, radiological outcomes revealed sustained and gradual efficacy in a longer term. Level of Evidence: Level 4. According to the Oxford Center for Evidence‐Based Medicine 2011 level of evidence guidelines, this non‐randomized retrospective cohort study is classified as level 4 evidence Laryngoscope, 134:2626–2633, 2024 [ABSTRACT FROM AUTHOR]
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- 2024
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35. Effect of an educational intervention delivered by pharmacists on adherence to treatment, disease control and lung function in patients with asthma
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Comar, Carlotta, Vaiarelli, Katia, Gioiella, Giuliana, Aprile, Carlo, Basile, Angelo, Battisti, Anna, Cavalli, Camilla, Cirino, Mario, Bella, Mirka Dalla, Demontis, Rita, Di Donato, Gaetano, Di Gangi, Rita, Esposito, Antonio, Falanga, Gyada, Ghetti, Patrizia, Fimiani, Giuseppe, Florio, Alessia, Floris, Enrico, Fontanesi, Alessandro, Giuffrida, Antonino, Guccione, Carmelo, Lancia, Laura, Lanzoni, Anna Maria, Leo, Azzurra, Leone, Chiara, Levantino, Paolo, Marchionni, Matteo, Miccichè, Maria, Moneghini, Francesco, Policicchio, Pia, Rauseo, Antonio, Romano, Flora, Sequenza, Maria Josè, Stabile, Stefania, Zacchia, Matilde, Zanetti, Stefano Iellousheg, Paoletti, Giovanni, Keber, Enrico, Heffler, Enrico, Malipiero, Giacomo, Baiardini, Ilaria, Canonica, Giorgio Walter, and Giua, Corrado
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- 2020
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36. Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
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Canonica, Giorgio Walter, Blasi, Francesco, Paggiaro, Pierluigi, Senna, Gianenrico, Passalacqua, Giovanni, Spanevello, Antonio, Aliberti, Stefano, Bagnasco, Diego, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Bucca, Caterina, Caiaffa, Maria F., Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Carpagnano, Giovanna E., Caruso, Cristiano, Centanni, Stefano, Conte, Maria E., Corsico, Angelo G., Cosmi, Lorenzo, Costantino, Maria T., Crimi, Nunzio, D’Alò, Simona, D'Amato, Maria, Del Giacco, Stefano, Farsi, Alessandro, Favero, Elisabetta, Foschino Barbaro, Maria P., Guarnieri, Gabriella, Guida, Giuseppe, Latorre, Manuela, Lo Cicero, Salvatore, Lombardi, Carlo, Macchia, Luigi, Mazza, Francesco, Menzella, Francesco, Milanese, Manlio, Montagni, Marcello, Montuschi, Paolo, Nucera, Eleonora, Parente, Roberta, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ricciardolo, Fabio L.M., Richeldi, Luca, Ridolo, Erminia, Rolla, Giovanni, Santus, Pierachille, Scichilone, Nicola, Spadaro, Giuseppe, Vianello, Andrea, Viviano, Vittorio, Yacoub, Mona R., Zappa, Maria C., and Heffler, Enrico
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- 2020
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37. Beliefs and preferences regarding biological treatments for severe asthma
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Ardelean, Carmen, Badellino, Hector, Blua, Ariel, Castillo, Antonio, Carpagnano Giovanna, E., Chong-Neto Herberto, J., Colodenco, F. Daniel, Md Colombaro, Dario, Correia-De-Sousa, Jaime, Di Marco, Fabiano, Dobashi, Kunio, Garcia, Rocio, Gomez, René Maximiliano, Gopko, Olecsandr, Guidos, Guillermo, Hajduk, Martina, Hermanowicz-Salamon, Joanna, Heffler, Enrico, Karadag, Bulent, Kalyoncu, Ali F., Keren, Metin, Kolilekas, Lykorguos, Kocwin, Marcelina, Krusheva, Borislava, Larenas Linnemann, Désirée, Litovchenko, Irine, Marcipar, A., Meza, L.E., Nedeva, D., Novakova, P., Plavec, D., Popović-Grle, S., Puggioni, F., Pur Oziygit, L., Rodrigez, N., Ryan, D., Ruzsics, I., Scichilone, N., Serpa, F., Steiropoulos, P., Solidoro, P., Turkalj, M., Umanets, T., Victorio, C.F., Zubeldia, J.M., Yachnyk, V., Zitt, M., Bikov, Andras, Oğuzülgen, Ipek Kivilcim, Baiardini, Ilaria, Contoli, Marco, Emelyanov, Alexander, Fassio, Omar, Ivancevich, Juan Carlos, Kaidashev, Igor, Kowal, Krzysztof, Labor, Marina, Lahousse, Lies, Mihaicuta, Stefan, Novakova, Silviya, Padilla Galo, Alicia, Simidchiev, Alexander, Tiotiu, Angelica, Ansotegui, Ignacio J., Bernstein, Jonathan A., Boulet, Louis Philippe, Canonica, Giorgio Walter, Dubuske, Lawrence, Rosario, Nelson, Santus, Pierachille, and Braido, Fulvio
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- 2020
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38. Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry
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Bonavia, M., Caiaffa, P., Calabrese, C., Camiciottoli, G., Caruso, C., Centanni, S., Conte, M.E., Corsico, A.G., Cosmi, L., Costantino, M.T., Crimi, N., D’Alò, S., D'Amato, M., Del Giacco, S., Favero, E., Farsi, A., Foschino, B.P.M., Guarnieri, G., Guida, G., Latorre, M., Lombardi, C., Macchia, L., Menzella, F., Milanese, M., Montuschi, P., Nucera, E., Parente, R., Passalacqua, G., Patella, V., Pelaia, G., Pini, L., Ricciardolo, F.L.M., Ricciardi, L., Richeldi, L., Ridolo, E., Rolla, G., Santus, P., Scichilone, N., Solidoro, P., Spadaro, G., Spanevello, A., Vianello, A., Yacoub, M.R., Zappa, M.C., Canonica, Giorgio Walter, Malvezzi, Luca, Blasi, Francesco, Paggiaro, Pierluigi, Mantero, Marco, Senna, Gianenrico, and Heffler, Enrico
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- 2020
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39. Acute asthma management during SARS-CoV2-pandemic 2020
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Levin, Michael, Ansotegui, Ignacio J., Bernstein, Jonathan, Chang, Yoon-Seok, Chikhladze, Manana, Ebisawa, Motohiro, Fiocchi, Alessandro, Heffler, Enrico, Martin, Bryan, Morais-Almeida, Mario, Papadopoulos, Nikolaos G., Peden, David, and Wong, Gary W.K.
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- 2020
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40. Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry
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Wang, Eileen, Wechsler, Michael E., Tran, Trung N., Heaney, Liam G., Jones, Rupert C., Menzies-Gow, Andrew N., Busby, John, Jackson, David J., Pfeffer, Paul E., Rhee, Chin Kook, Cho, You Sook, Canonica, G. Walter, Heffler, Enrico, Gibson, Peter G., Hew, Mark, Peters, Matthew, Harvey, Erin S., Alacqua, Marianna, Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Murray, Ruth B., and Price, David B.
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- 2020
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41. International Severe Asthma Registry: Mission Statement
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Canonica, G. Walter, Alacqua, Marianna, Altraja, Alan, Backer, Vibeke, Bel, Elisabeth, Bjermer, Leif, Bjornsdottir, Unnur, Bourdin, Arnaud, Brusselle, Guy G., Christoff, George C., Cosio, Borja G., Costello, Richard W., FitzGerald, J. Mark, Gibson, Peter G., Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Jones, Rupert C., Siyue, Mariko Koh, Rhee, Chin Kook, Lehmann, Sverre, Lehtimäki, Lauri A., Ludviksdottir, Dora, Maitland-van der Zee, Anke-Hilse, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Plaza, Vicente, Perez de Llano, Luis, Peters, Matthew, Porsbjerg, Celeste M., Sadatsafavi, Mohsen, Cho, You Sook, Tohda, Yuji, Tran, Trung N., Wang, Eileen, Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Le, Thao L., Murray, Ruth B., Price, Chris A., and Price, David B.
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- 2020
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42. Reply to “Exploring the long-term effects of biologic initiation in severe asthma: Insights from the International Severe Asthma Registry”
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Chen, Wenjia, primary, Tran, Trung N., additional, Sadatsafavi, Mohsen, additional, Murray, Ruth B., additional, Boon Wong, Nigel Chong, additional, Ali, Nasloon, additional, Ariti, Con, additional, Bulathsinhala, Lakmini, additional, Garcia Gil, Esther, additional, FitzGerald, J. Mark, additional, Alacqua, Marianna, additional, Al-Ahmad, Mona, additional, Altraja, Alan, additional, Al-Lehebi, Riyad, additional, Bhutani, Mohit, additional, Bjermer, Leif, additional, Bjerrum, Anne-Sofie, additional, Bourdin, Arnaud, additional, von Bülow, Anna, additional, Busby, John, additional, Canonica, Giorgio Walter, additional, Carter, Victoria, additional, Christoff, George C., additional, Cosio, Borja G., additional, Costello, Richard W., additional, Fonseca, João A., additional, Gibson, Peter G., additional, Yoo, Kwang Ha, additional, Heaney, Liam G., additional, Heffler, Enrico, additional, Hew, Mark, additional, Hilberg, Ole, additional, Hoyte, Flavia, additional, Iwanaga, Takashi, additional, Jackson, David J., additional, Jones, Rupert C., additional, Koh, Mariko Siyue, additional, Kuna, Piotr, additional, Larenas-Linnemann, Désirée, additional, Lehmann, Sverre, additional, Lehtimäki, Lauri, additional, Lyu, Juntao, additional, Mahboub, Bassam, additional, Maspero, Jorge, additional, Menzies-Gow, Andrew N., additional, Newell, Anthony, additional, Sirena, Concetta, additional, Papadopoulos, Nikolaos G., additional, Papaioannou, Andriana I., additional, Perez-de-Llano, Luis, additional, Perng (Steve), Diahn-Warng, additional, Peters, Matthew J., additional, Pfeffer, Paul E., additional, Porsbjerg, Celeste M., additional, Popov, Todor A., additional, Rhee, Chin Kook, additional, Salvi, Sundeep, additional, Taillé, Camille, additional, Taube, Christian, additional, Torres-Duque, Carlos A., additional, Ulrik, Charlotte, additional, Ra, Seung Won, additional, Wang, Eileen, additional, Wechsler, Michael E., additional, and Price, David B., additional
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- 2024
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43. Baseline Disease Characteristics Among Patients with Chronic Rhinosinusitis with Nasal Polyps and Coexisting Asthma in the Global AROMA registry
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Peters, Anju, primary, Heffler, Enrico, additional, Laidlaw, Tanya, additional, Fujieda, Shigeharu, additional, Nash, Scott, additional, Xia, Changming, additional, Johnson, Micah, additional, De Prado Gomez, Lucia, additional, Rowe, Paul, additional, Deniz, Yamo, additional, Jacob-Nara, Juby, additional, and Sacks, Harry, additional
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- 2024
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44. Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?
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Giombi, Francesco, primary, Pace, Gian Marco, additional, Pirola, Francesca, additional, Cerasuolo, Michele, additional, Ferreli, Fabio, additional, Mercante, Giuseppe, additional, Spriano, Giuseppe, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Ferri, Sebastian, additional, Puggioni, Francesca, additional, Paoletti, Giovanni, additional, and Malvezzi, Luca, additional
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- 2024
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45. Radiological Versus Clinical 1‐Year Outcomes of Dupilumab in Refractory CRSwNP: A Real‐Life Study
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Giombi, Francesco, primary, Pace, Gian Marco, additional, Nappi, Emanuele, additional, Giunta, Gianmarco, additional, Muci, Giovanna, additional, Pirola, Francesca, additional, Ferreli, Fabio, additional, Heffler, Enrico, additional, Paoletti, Giovanni, additional, Giannitto, Caterina, additional, Mercante, Giuseppe, additional, Francone, Marco, additional, Spriano, Giuseppe, additional, Canonica, Giorgio Walter, additional, and Malvezzi, Luca, additional
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- 2023
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46. EUFOREA/EPOS2020 statement on the clinical considerations for CRSwNP care
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Hellings, Peter W., primary, Alobid, Isam, additional, Anselmo‐Lima, Wilma T., additional, Bernal‐Sprekelsen, Manuel, additional, Bjermer, Leif, additional, Caulley, Lisa, additional, Chaker, Adam, additional, Constantinidis, Jannis, additional, Conti, Diego M., additional, De Corso, Eugenio, additional, Desrosiers, Martin, additional, Diamant, Zuzana, additional, Gevaert, Philippe, additional, Han, Joseph K., additional, Heffler, Enrico, additional, Hopkins, Claire, additional, Landis, Basile N., additional, Lourenco, Olga, additional, Lund, Valerie, additional, Luong, Amber U., additional, Mullol, Joaquim, additional, Peters, Anju, additional, Philpott, Carl, additional, Reitsma, Sietze, additional, Ryan, Dermot, additional, Scadding, Glenis, additional, Senior, Brent, additional, Tomazic, Peter Valentin, additional, Toskala, Elina, additional, Van Zele, Thibaut, additional, Viskens, An‐Sofie, additional, Wagenmann, Martin, additional, and Fokkens, W. J., additional
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- 2023
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47. Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
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Perez-de-Llano, Luis, primary, Scelo, Ghislaine, additional, Canonica, G. Walter, additional, Chen, Wenjia, additional, Henley, William, additional, Larenas-Linnemann, Désirée, additional, Peters, Matthesadatw J, additional, Pfeffer, Paul E., additional, Tran, Trung N., additional, Ulrik, Charlotte Suppli, additional, Popov, Todor A., additional, Sadatsafavi, Mohsen, additional, Hew, Mark, additional, Maspero, Jorge, additional, Gibson, Peter G., additional, Christoff, George C., additional, Fitzgerald, J. Mark, additional, Torres-Duque, Carlos A., additional, Porsbjerg, Celeste M., additional, Papadopoulos, Nikolaos G., additional, Papaioannou, Andriana I., additional, Heffler, Enrico, additional, Iwanaga, Takashi, additional, Al-Ahmad, Mona, additional, Kuna, Piotr, additional, Fonseca, João A, additional, Al-Lehebi, Riyad, additional, Rhee, Chin Kook, additional, Koh, Mariko Siyue, additional, Cosio, Borja G., additional, Perng (Steve), Diahn-Warng, additional, Mahboub, Bassam, additional, Menzies-Gow, Andrew N., additional, Jackson, David J., additional, Busby, John, additional, Heaney, Liam G., additional, Patel, Pujan H, additional, Wang, Eileen, additional, Wechsler, Michael E., additional, Altraja, Alan, additional, Lehtimäki, Lauri, additional, Bourdin, Arnaud, additional, Bjermer, Leif, additional, Bulathsinhala, Lakmini, additional, Carter, Victoria, additional, Murray, Ruth, additional, Beastall, Aaron, additional, Denton, Eve, additional, and Price, David B., additional
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- 2023
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48. Sudden neck swelling with rash as late manifestation of COVID-19: a case report
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Giannitto, Caterina, Bonifacio, Cristiana, Esposito, Susanna, Ammirabile, Angela, Mercante, Giuseppe, De Virgilio, Armando, Spriano, Giuseppe, Heffler, Enrico, Lofino, Ludovica, Politi, Letterio Salvatore, and Balzarini, Luca
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- 2021
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49. The Severe Asthma Network in Italy: Findings and Perspectives
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Barbuto, Sarah, Bradicich, Matteo, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino, Maria Teresa, Crimi, Nunzio, Crivellaro, Mariangiola, D’Adda, Alice, D’Amato, Mariella, Favero, Elisabetta, Foschino, Maria Pia, Galeone, Carla, Guarnieri, Gabriella, Lombardi, Carlo, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, Heffler, Enrico, Blasi, Francesco, Latorre, Manuela, Menzella, Francesco, Paggiaro, Pierluigi, Pelaia, Girolamo, Senna, Gianenrico, and Canonica, Giorgio Walter
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- 2019
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50. Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry
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Aliberti, Stefano, Bagnasco, Diego, Barbuto, Sarah, Camiciottoli, Gianna, Caminati, Marco, Colombo, Giselda, Costantino Maria, Teresa, Crimi, Claudia, Crivellaro, Mariangiola, D'Amato, Mariella, Favero, Elisabetta, Foschino Maria, Pia, Guarnieri, Gabriella, Latorre, Manuela, Lombardi, Carlo, Menzella, Francesco, Patella, Vincenzo, Puggioni, Francesca, Ridolo, Erminia, Rolla, Giovanni, Savi, Eleonora, Scichilone, Nicola, Solidoro, Paolo, Spadaro, Giuseppe, Triggiani, Massimo, Canonica, Giorgio Walter, Colombo, Giorgio Lorenzo, Bruno, Giacomo Matteo, Di Matteo, Sergio, Martinotti, Chiara, Blasi, Francesco, Bucca, Caterina, Crimi, Nunzio, Paggiaro, Pierluigi, Pelaia, Girolamo, Passalaqua, Giovanni, Senna, Gianenrico, and Heffler, Enrico
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- 2019
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