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1. Treatment of elderly patients with non-ST-elevation myocardial infarction: the nationwide POPular age registry

Author: Gimbel, Marieke E., Chan Pin Yin, Dean R. P. P., van den Broek, Wout W. A., Hermanides, Renicus S., Kauer, Floris, Tavenier, Annerieke H., Schellings, Dirk, Brinckman, Stijn L., The, Salem H. K., Stoel, Martin G., Heestermans, Ton A. C. M., Rasoul, Saman, Emans, Mireille E., van de Wetering, Machiel, van Bergen, Paul F. M. M., Walhout, Ronald, Nicastia, Debby, Aksoy, Ismail, van ’t Hof, Arnoud, Knaapen, Paul, Botman, Cees-Joost, Liem, Anho, de Nooijer, Cornelis, Peper, Joyce, Kelder, Johannes C., and ten Berg, Jurriën M.
Published: 2024
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2. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy

Author: Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Published: 2024
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3. The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study

Author: Janssens, Gladys N., Daemen, Joost, Lemkes, Jorrit S., Spoormans, Eva M., Janssen, Dieuwertje, den Uil, Corstiaan A., Jewbali, Lucia S. D., Heestermans, Ton A. C. M., Umans, Victor A. W. M., Halfwerk, Frank R., Beishuizen, Albertus, Nas, Joris, Bonnes, Judith, van de Ven, Peter M., van Rossum, Albert C., Elbers, Paul W. G., and van Royen, Niels
Published: 2022
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4. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation:A COACT Substudy

Author: Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, van Royen, Niels, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Abstract: Background: In out-of-hospital cardiac arrest (OHCA) without ST-elevation, predictive markers that can identify those with a high risk of acute coronary syndrome are lacking. Methods: In this post hoc analysis of the Coronary Angiography after Cardiac Arrest (COACT) trial, the baseline, median, peak, and time-concentration curves of troponin-T (cTnT) (T-AUC) in OHCA patients without ST-elevation were studied. cTnT values were obtained at predefined time points at 0, 3, 6, 12, 24, 36, 28, and 72 hours after admission. All patients who died within the measurement period were not included. The primary outcome was the association between cTnT and 90-day survival. Secondary outcomes included the association of cTnT and acute thrombotic occlusions, acute unstable lesions, and left ventricular function. Results: In total, 352 patients were included in the analysis. The mean age was 64 ± 13 years (80.4% men). All cTnT measures were independent prognostic factors for mortality after adjustment for potential confounders age, sex, history of coronary artery disease, witnessed arrest, time to BLS, and time to return of spontaneous circulation (eg, for T-AUC: hazard ratio, 1.44; 95% CI, 1.06-1.94; P = .02; P value for all variables ≤ .02). Median cTnT (odds ratio [OR], 1.58; 95% CI, 1.18-2.12; P = .002) and T-AUC (OR, 2.03; 95% CI, 1.25-3.29; P = .004) were independent predictors for acute unstable lesions. Median cTnT (OR, 1.62; 95% CI, 1.17-2.23; P = .003) and T-AUC (OR, 2.16; 95% CI, 1.27-3.68; P = .004) were independent predictors for acute thrombotic occlusions. CTnT values were not associated with the left ventricular function (eg, for T-AUC: OR, 2.01; 95% CI, 0.65-6.19; P = .22; P value for all variables ≥ .14)Conclusion:In OHCA patients without ST-segment elevation, cTnT release during the first 72 hours after return of spontaneous circulation was associated with clinical outcomes.
Published: 2024

5. The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy

Author: Cardiologie, Team Medisch, Gezonde Vaten, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, van Royen, Niels, Cardiologie, Team Medisch, Gezonde Vaten, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., van der Pas, Stéphanie, and van Royen, Niels
Published: 2024

6. OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions

Author: Holm, Niels R., primary, Andreasen, Lene N., additional, Neghabat, Omeed, additional, Laanmets, Peep, additional, Kumsars, Indulis, additional, Bennett, Johan, additional, Olsen, Niels T., additional, Odenstedt, Jacob, additional, Hoffmann, Pavel, additional, Dens, Jo, additional, Chowdhary, Saqib, additional, O’Kane, Peter, additional, Bülow Rasmussen, Søren-Haldur, additional, Heigert, Matthias, additional, Havndrup, Ole, additional, Van Kuijk, Jan P., additional, Biscaglia, Simone, additional, Mogensen, Lone J.H., additional, Henareh, Loghman, additional, Burzotta, Francesco, additional, H. Eek, Christian, additional, Mylotte, Darren, additional, Llinas, Miquel S., additional, Koltowski, Lukasz, additional, Knaapen, Paul, additional, Calic, Slobodan, additional, Witt, Nils, additional, Santos-Pardo, Irene, additional, Watkins, Stuart, additional, Lønborg, Jacob, additional, Kristensen, Andreas T., additional, Jensen, Lisette O., additional, Calais, Fredrik, additional, Cockburn, James, additional, McNeice, Andrew, additional, Kajander, Olli A., additional, Heestermans, Ton, additional, Kische, Stephan, additional, Eftekhari, Ashkan, additional, Spratt, James C., additional, and Christiansen, Evald H., additional
Published: 2023
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7. The Prognostic Value of Troponin-T in OHCA Without ST-Segment Elevation: A COACT Trial’s Secondary Analysis

Author: Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, van der Harst, Pim, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, van der Pas, Stéphanie, additional, and van Royen, Niels, additional
Published: 2023
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8. Treatment of elderly patients with non-ST-elevation myocardial infarction: the nationwide POPular age registry

Author: Gimbel, Marieke E., primary, Chan Pin Yin, Dean R. P. P., additional, van den Broek, Wout W. A., additional, Hermanides, Renicus S., additional, Kauer, Floris, additional, Tavenier, Annerieke H., additional, Schellings, Dirk, additional, Brinckman, Stijn L., additional, The, Salem H. K., additional, Stoel, Martin G., additional, Heestermans, Ton A. C. M., additional, Rasoul, Saman, additional, Emans, Mireille E., additional, van de Wetering, Machiel, additional, van Bergen, Paul F. M. M., additional, Walhout, Ronald, additional, Nicastia, Debby, additional, Aksoy, Ismail, additional, van ’t Hof, Arnoud, additional, Knaapen, Paul, additional, Botman, Cees-Joost, additional, Liem, Anho, additional, de Nooijer, Cornelis, additional, Peper, Joyce, additional, Kelder, Johannes C., additional, and ten Berg, Jurriën M., additional
Published: 2023
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9. OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions

Author: Holm, Niels R, Andreasen, Lene N, Neghabat, Omeed, Laanmets, Peep, Kumsars, Induli, Bennett, Johan, Olsen, Niels T, Odenstedt, Jacob, Hoffmann, Pavel, Dens, Jo, Chowdhary, Saqib, O'Kane, Peter, Bülow Rasmussen, Søren-Haldur, Heigert, Matthia, Havndrup, Ole, Van Kuijk, Jan P, Biscaglia, Simone, Mogensen, Lone J H, Henareh, Loghman, Burzotta, Francesco, H Eek, Christian, Mylotte, Darren, Llinas, Miquel S, Koltowski, Lukasz, Knaapen, Paul, Calic, Slobodan, Witt, Nil, Santos-Pardo, Irene, Watkins, Stuart, Lønborg, Jacob, Kristensen, Andreas T, Jensen, Lisette O, Calais, Fredrik, Cockburn, Jame, Mcneice, Andrew, Kajander, Olli A, Heestermans, Ton, Kische, Stephan, Eftekhari, Ashkan, Spratt, James C, Christiansen, Evald H, Burzotta, Francesco (ORCID:0000-0002-6569-9401), Holm, Niels R, Andreasen, Lene N, Neghabat, Omeed, Laanmets, Peep, Kumsars, Induli, Bennett, Johan, Olsen, Niels T, Odenstedt, Jacob, Hoffmann, Pavel, Dens, Jo, Chowdhary, Saqib, O'Kane, Peter, Bülow Rasmussen, Søren-Haldur, Heigert, Matthia, Havndrup, Ole, Van Kuijk, Jan P, Biscaglia, Simone, Mogensen, Lone J H, Henareh, Loghman, Burzotta, Francesco, H Eek, Christian, Mylotte, Darren, Llinas, Miquel S, Koltowski, Lukasz, Knaapen, Paul, Calic, Slobodan, Witt, Nil, Santos-Pardo, Irene, Watkins, Stuart, Lønborg, Jacob, Kristensen, Andreas T, Jensen, Lisette O, Calais, Fredrik, Cockburn, Jame, Mcneice, Andrew, Kajander, Olli A, Heestermans, Ton, Kische, Stephan, Eftekhari, Ashkan, Spratt, James C, Christiansen, Evald H, and Burzotta, Francesco (ORCID:0000-0002-6569-9401)
Abstract: Background: Imaging-guided percutaneous coronary intervention (PCI) is associated with better clinical outcomes than angiography-guided PCI. Whether routine optical coherence tomography (OCT) guidance in PCI of lesions involving coronary-artery branch points (bifurcations) improves clinical outcomes as compared with angiographic guidance is uncertain. Methods: We conducted a multicenter, randomized, open-label trial at 38 centers in Europe. Patients with a clinical indication for PCI and a complex bifurcation lesion identified by means of coronary angiography were randomly assigned in a 1:1 ratio to OCT-guided PCI or angiography-guided PCI. The primary end point was a composite of major adverse cardiac events (MACE), defined as death from a cardiac cause, target-lesion myocardial infarction, or ischemia-driven target-lesion revascularization at a median follow-up of 2 years. Results: We assigned 1201 patients to OCT-guided PCI (600 patients) or angiography-guided PCI (601 patients). A total of 111 patients (18.5%) in the OCT-guided PCI group and 116 (19.3%) in the angiography-guided PCI group had a bifurcation lesion involving the left main coronary artery. At 2 years, a primary end-point event had occurred in 59 patients (10.1%) in the OCT-guided PCI group and in 83 patients (14.1%) in the angiography-guided PCI group (hazard ratio, 0.70; 95% confidence interval, 0.50 to 0.98; P = 0.035). Procedure-related complications occurred in 41 patients (6.8%) in the OCT-guided PCI group and 34 patients (5.7%) in the angiography-guided PCI group. Conclusions: Among patients with complex coronary-artery bifurcation lesions, OCT-guided PCI was associated with a lower incidence of MACE at 2 years than angiography-guided PCI. (Funded by Abbott Vascular and others; OCTOBER ClinicalTrials.gov number, NCT03171311.).
Published: 2023

10. Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H24 Analysis

Author: Bougherbal, Rachid, Bouafia, Mohamed Tahar, Chettibi, Mohamed, Nibouche, Djamaleddine, Moklati, Abdelkader, Benalia, Ahmed, Kaid, Omar, Krim, Messaad, Hammett, Christopher, Garrahy, Paul, Jayasinghe, Rohan, Rashford, Stephen, Huber, Kurt, Neunteufl, Thomas, Brussee, Helmut, Alber, Hannes, Weidinger, Franz, Brunner, Michael, Sipoetz, Johann, Prause, Gerhard, Baubin, Michael, Sebald, Dieter, Cantor, Warren, Vijayaraghavan, Ram, Bata, Iqbal, Lavoie, Andrea, Lassen, Jens Flensted, Ravkilde, Jan, Jensen, Lisette Okkels, Christensen, Alf Møl, Toftegaard, Marianne, Köhler, Dennis, Montalescot, Gilles, Ducrocq, Gregory, Danchin, Nicolas, Henry, Patrick, Livarek, Bernard, Berthier, Romain, Hovasse, Thomas, Garot, Philippe, Payot, Laurent, Benamer, Hakim, Esteve, Jean Baptiste, Elhadad, Simon, Teiger, Emmanuel, Bonnet, Jean Louis, Paganelli, Franck, Cottin, Yves, Schiele, François, Thuaire, Christophe, Cayla, Guillaume, Coste, Pierre, Ohlmann, Patrick, Cudraz, Eric Bonnefoy, Lantelme, Pierre, Perret, Thibault, Tron, Christophe, De Labriolle, Axel, Aptecar, Edouardo, Beliard, Olivier, Varenne, Olivier, El Mahmoud, Rami, Filippi-Codaccioni, Emmanuelle, Angoulvant, Denis, Peycher, Patrick, Poitrineau, Olivier, Tabone, Xavier, Ecollan, Patrick, Broche, Claire, Lambert, Yves, Briole, Nicolas, Beruben, Arielle, Porcher, Nicolas, Auffray, Jean-Pierre, Freysz, Marc, Depardieu, Franck, Poubel, David, De La Cousaye, Jean-Emmanuel, Bartier, Jean-Claude, Jardel, Benoît, Boulanger, Bertrand, Labourel, Hervé, Soulat, Louis-Christophe, Lapostolle, Frédéric, Julie, Véronique, Thicoipe, Michel, Capel, Olivier, Stibbe, Olivier, Carli, Pierre, Tazarourte, Karim, Alcouffe, Fabrice, Aboucaya, David, Aubert, Gaële, Kierzek, Gérald, Cahun-Giraud, Séverine, Zeymer, Uwe, Hamm, Christian, Dengler, Thomas, Prondzinsky, Roland, Biever, Paul Marc, Schäfer, Andreas, Seyfarth, Melchior, Lemke, Bernd, Werner, Gerald, Nef, Holger, Steiger, Holger, Leschke, Matthias, Münzel, Thomas, Dell Orto, Marco Campo, Loges, Christian, Schinke, Monika, Koberne, Frank, Reiffen, Hans Peter, Tiroch, Klaus, Wierich, Dirk, Kneussel, Michael, Little, Simon, Sauer, Hartmut, Laufenberg-Feldmann, Rita, Merkely, Béla, Ungi, Imre, Horváth, Iván, Édes, István, Mártai, István, Bolognese, Leonardo, Berti, Sergio, Chiarella, Francesco, Calabria, Paolo, Fineschi, Massimo, Galvani, Marcello, Valgimigli, Marco, Moretti, Luciano, Tespili, Maurizio, Mandó, Massimo, Bermano, Francesco, Biagioni, Robusto, Fabbri, Andrea, Ricciardelli, Adelina, Petroni, Maria Romana, Vatteroni, Umberto Roberto, Palumbo, Francesco, Willems, Frank F., Al Mafragi, Amar, Heestermans, Ton A.A.C.M., Van Eck, Martijn J., Heutz, Wim M.J.M., Meppelder, H.H., Jong, Anika Roukema-de, Van de Pas, Harm, Fillat, Ángel Cequier, Tenas, Manel Sabaté, Ferrer, Josepa Mauri, Peñaranda, Antoni Serra, Ferrer, Joan Ángel, Del Blanco, Bruno García, Guardiola, Faustino Miranda, Ruiz Nodar, Juan Miguel, Romo, Andrés Íñiguez, González, Nicolás Vázquez, Nouche, Ramiro Trillo, De La Llera, Luis Díaz, Hernández García, José María, Rivero-Crespo, Fernando, Hernández, Felipe Hernández, Zamorano Gómez, José Luis, Fárega, Xavier Jiménez, Fernández, Gilberto Alonso, Toboso, José Luis, Carrasco, Mercedes, Barreiro, Victoria, Iglesias Vázquez, José Antonio, Montero, María del Mar Ruiz, Ortiz, Fernando Rosell, Escudero, Guillermo Garcia, Ingelmo, Vicente Sánchez-Brunete, García, Antonio Lara, Janzon, Magnus, Oldgren, Jonas, Calais, Fredrik, Kastberg, Robert, Bergsten, Per-Adolf, Blomberg, Hans, Thörn, Kristian, Skoog, Gunnar, Storey, Robert F., Zaman, Azfar, Gerber, Robert, Ryding, Alisdair, Spence, Mark, Swanson, Neil, Been, Martin, Grosser, Konrad, Schofield, Peter, Mackin, David, Fell, Paul, Quinn, Tom, Foster, Teresa, McManus, David, Carson, Andy, van ’t Hof, Arnoud W., Cantor, Warren J., Cequier, Angel, Collet, Jean-Philippe, Goodman, Shaun G., Hammett, Christopher J., Licour, Muriel, Salhi, Néjoua, Silvain, Johanne, ten Berg, Jurriën M., Tsatsaris, Anne, Vicaut, Eric, and Hamm, Christian W.
Published: 2016
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11. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials’ post-hoc subgroup analysis

Author: Spoormans, Eva M, primary, Lemkes, Jorrit S, additional, Janssens, Gladys N, additional, Soultana, Ouissal, additional, van der Hoeven, Nina W, additional, Jewbali, Lucia S D, additional, Dubois, Eric A, additional, Meuwissen, Martijn, additional, Rijpstra, Tom A, additional, Bosker, Hans A, additional, Blans, Michiel J, additional, Bleeker, Gabe B, additional, Baak, Remon, additional, Vlachojannis, Georgios J, additional, Eikemans, Bob J W, additional, van der Harst, Pim, additional, van der Horst, Iwan C C, additional, Voskuil, Michiel, additional, van der Heijden, Joris J, additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P, additional, Vlaar, Alexander P J, additional, Vink, Maarten A, additional, van den Bogaard, Bas, additional, Heestermans, Ton A C M, additional, de Ruijter, Wouter, additional, Delnoij, Thijs S R, additional, Crijns, Harry J G M, additional, Oemrawsingh, Pranobe V, additional, Gosselink, Marcel T M, additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W G, additional, van de Ven, Peter M, additional, and van Royen, Niels, additional
Published: 2022
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12. The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients:a retrospective cohort study

Author: Janssens, Gladys N., Daemen, Joost, Lemkes, Jorrit S., Spoormans, Eva M., Janssen, Dieuwertje, den Uil, Corstiaan A., Jewbali, Lucia S.D., Heestermans, Ton A.C.M., Umans, Victor A.W.M., Halfwerk, Frank R., Beishuizen, Albertus, Nas, Joris, Bonnes, Judith, van de Ven, Peter M., van Rossum, Albert C., Elbers, Paul W.G., van Royen, Niels, Janssens, Gladys N., Daemen, Joost, Lemkes, Jorrit S., Spoormans, Eva M., Janssen, Dieuwertje, den Uil, Corstiaan A., Jewbali, Lucia S.D., Heestermans, Ton A.C.M., Umans, Victor A.W.M., Halfwerk, Frank R., Beishuizen, Albertus, Nas, Joris, Bonnes, Judith, van de Ven, Peter M., van Rossum, Albert C., Elbers, Paul W.G., and van Royen, Niels
Abstract: Background: Acute kidney injury (AKI) is a frequent complication in cardiac arrest survivors and associated with adverse outcome. It remains unclear whether the incidence of AKI increases after the post-cardiac arrest contrast administration for coronary angiography and whether this depends on timing of angiography. Aim of this study was to investigate whether early angiography is associated with increased development of AKI compared to deferred angiography in out-of-hospital cardiac arrest (OHCA) survivors. Methods: In this retrospective multicenter cohort study, we investigated whether early angiography (within 2 h) after OHCA was non-inferior to deferred angiography regarding the development of AKI. We used an absolute difference of 5% as the non-inferiority margin. Primary non-inferiority analysis was done by calculating the risk difference with its 90% confidence interval (CI) using a generalized linear model for a binary outcome. As a sensitivity analysis, we repeated the primary analysis using propensity score matching. A multivariable model was built to identify predictors of acute kidney injury. Results: A total of 2375 patients were included from 2009 until 2018, of which 1148 patients were treated with early coronary angiography and 1227 patients with delayed or no angiography. In the early angiography group 18.5% of patients developed AKI after OHCA and 24.1% in the deferred angiography group. Risk difference was − 3.7% with 90% CI ranging from − 6.7 to − 0.7%, indicating non-inferiority of early angiography. The sensitivity analysis using propensity score matching showed accordant results, but no longer non-inferiority of early angiography. The factors time to return of spontaneous circulation (odds ratio [OR] 1.12, 95% CI 1.06–1.19, p < 0.001), the (not) use of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker (OR 0.20, 95% CI 0.04–0.91, p = 0.04) and baseline creatinine (OR 1.05, 95% CI 1.03–1.07, p < 0.001) were foun
Published: 2022

13. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, and van Royen, Niels
Published: 2022

14. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, and van Royen, Niels
Published: 2022

15. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, Elbers, Paul W G, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, and Elbers, Paul W G
Published: 2022

16. Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis: A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort)

Author: Adriaenssens, Tom, Joner, Michael, Godschalk, Thea C., Malik, Nikesh, Alfonso, Fernando, Xhepa, Erion, De Cock, Dries, Komukai, Kenichi, Tada, Tomohisa, Cuesta, Javier, Sirbu, Vasile, Feldman, Laurent J., Neumann, Franz-Josef, Goodall, Alison H., Heestermans, Ton, Buysschaert, Ian, Hlinomaz, Ota, Belmans, Ann, Desmet, Walter, ten Berg, Jurrien M., Gershlick, Anthony H., Massberg, Steffen, Kastrati, Adnan, Guagliumi, Giulio, and Byrne, Robert A.
Published: 2017
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17. THE PROGNOSTIC VALUE OF TROPONIN IN OHCA PATIENTS WITHOUT ST-SEGMENT ELEVATION: A COACT TRIAL SUBSTUDY

Author: Spoormans, Eva Marie, primary, Lemkes, Jorrit, additional, Janssens, Gladys, additional, van der Hoeven, Nina Willemijn, additional, Jewbali, L. S.D., additional, Meuwissen, Martijn, additional, Bosker, Hans, additional, Bleeker, Gabe, additional, Baak, Rémon, additional, Vlachojannis, Georgios, additional, van der Harst, Pim, additional, Voskuil, Michiel, additional, Beishuizen, Albertus, additional, Camaro, Cyril, additional, Henriques, José P., additional, Vink, Maarten, additional, Heestermans, Ton, additional, Delnoij, Thijs, additional, Oemrawsingh, Pranobe, additional, Gosselink, Marcel, additional, Plomp, Koos, additional, Magro, Michiel, additional, Elbers, Paul, additional, van de Ven, Peter, additional, and Van Royen, Niels, additional
Published: 2022
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18. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author: Camaro, Cyril, primary, Bonnes, Judith L., additional, Adang, Eddy M., additional, Spoormans, Eva M., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Rémon, additional, Vlachojannis, George J., additional, Eikemans, Bob J., additional, van der Harst, Pim, additional, van der Horst, Iwan C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Bert, additional, Stoel, Martin, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S., additional, Crijns, Harry J., additional, Jessurun, Gillian A., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W., additional, van de Ven, Peter M., additional, Lemkes, Jorrit S., additional, and van Royen, Niels, additional
Published: 2022
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19. Additional file 1 of The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study

Author: Janssens, Gladys N., Daemen, Joost, Lemkes, Jorrit S., Spoormans, Eva M., Janssen, Dieuwertje, den Uil, Corstiaan A., Jewbali, Lucia S. D., Heestermans, Ton A. C. M., Umans, Victor A. W. M., Halfwerk, Frank R., Beishuizen, Albertus, Nas, Joris, Bonnes, Judith, van de Ven, Peter M., van Rossum, Albert C., Elbers, Paul W. G., and van Royen, Niels
Abstract: Additional file 1. AKI definition, Additional statistical analysis, Table S1-7, Figure S1.
Published: 2022
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20. The golden hour of prehospital reperfusion with triple antiplatelet therapy: A sub-analysis from the Ongoing Tirofiban in Myocardial Evaluation 2 (On-TIME 2) trial early initiation of triple antiplatelet therapy

Author: Heestermans, Ton, van 't Hof, Arnoud W.J., ten Berg, Jurriën M., van Werkum, Jochem W., Boersma, Eric, Mosterd, Arend, Stella, Pieter R., van Zoelen, Arthur B., Gosselink, A.T. Marcel, Kochman, Waclav, Dill, Thorsten, Koopmans, Petra C., van Houwelingen, Gert, Zijlstra, Felix, and Hamm, Christian
Published: 2010
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21. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author: Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S. D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J. W., additional, Girbes, Armand R. J., additional, van der Harst, Pim, additional, van der Horst, Iwan C. C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P. J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A. C. M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S. R., additional, Crijns, Harry J. G. M., additional, Jessurun, Gillian A. J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T. M., additional, Plomp, Koos, additional, Magro, Michael, additional, van de Ven, Peter M., additional, van Royen, Niels, additional, and Elbers, Paul W. G., additional
Published: 2021
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22. The Influence of Timing of Coronary Angiography on Acute Kidney Injury in Out-of-Hospital Cardiac Arrest Patients: A Retrospective Cohort Study.

Author: Janssens, Gladys Nathalia, primary, Daemen, Joost, additional, Lemkes, Jorrit S., additional, Spoormans, Eva M., additional, Janssen, Dieuwertje, additional, Uil, Corstiaan A. den, additional, Jewbali, Lucia S.D., additional, Heestermans, Ton A.C.M., additional, Umans, Victor A.W.M., additional, Halfwerk, Frank R., additional, Beishuizen, Albertus, additional, Nas, Joris, additional, Bonnes, Judith, additional, de Ven, Peter M. van, additional, Rossum, Albert C. van, additional, Elbers, Paul W.G., additional, and Royen, Niels van, additional
Published: 2021
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23. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author: Lemkes, Jorrit S., primary, Spoormans, Eva M., additional, Demirkiran, Ahmet, additional, Leutscher, Sophie, additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Rémon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, van der Harst, Pim, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Jessurun, Gillian A.J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, van de Ven, Peter M., additional, van Loon, Ramon B., additional, and van Royen, Niels, additional
Published: 2021
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24. Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients

Author: Claassens, Daniel M.F., primary, Gimbel, Marieke E., additional, Bergmeijer, Thomas O., additional, Vos, Gerrit J.A., additional, Hermanides, Renicus S., additional, van der Harst, Pim, additional, Barbato, Emanuele, additional, Morisco, Carmine, additional, Tjon Joe Gin, Richard M., additional, de Vrey, Evelyn A., additional, Heestermans, Ton A.C.M., additional, Jukema, J. Wouter, additional, von Birgelen, Clemens, additional, Waalewijn, Reinier A., additional, Hofma, Sjoerd H., additional, den Hartog, Frank R., additional, Voskuil, Michiel, additional, van't Hof, Arnoud W.J., additional, Asselbergs, Folkert W., additional, Mosterd, A., additional, Herrman, Jean-Paul R., additional, Dewilde, Willem, additional, Mahmoodi, Bakhtawar K., additional, Deneer, Vera H.M., additional, and ten Berg, Jurriën M., additional
Published: 2021
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25. Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients

Author: Claassens, Daniel M.F., Gimbel, Marieke E., Bergmeijer, Thomas O., Vos, Gerrit J.A., Hermanides, Renicus S., van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M., de Vrey, Evelyn A., Heestermans, Ton A.C.M., Jukema, J. Wouter, von Birgelen, Clemens, Waalewijn, Reinier A., Hofma, Sjoerd H., den Hartog, Frank R., Voskuil, Michiel, van't Hof, Arnoud W.J., Asselbergs, Folkert W., Mosterd, A., Herrman, Jean Paul R., Dewilde, Willem, Mahmoodi, Bakhtawar K., Deneer, Vera H.M., ten Berg, Jurriën M., Claassens, Daniel M.F., Gimbel, Marieke E., Bergmeijer, Thomas O., Vos, Gerrit J.A., Hermanides, Renicus S., van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M., de Vrey, Evelyn A., Heestermans, Ton A.C.M., Jukema, J. Wouter, von Birgelen, Clemens, Waalewijn, Reinier A., Hofma, Sjoerd H., den Hartog, Frank R., Voskuil, Michiel, van't Hof, Arnoud W.J., Asselbergs, Folkert W., Mosterd, A., Herrman, Jean Paul R., Dewilde, Willem, Mahmoodi, Bakhtawar K., Deneer, Vera H.M., and ten Berg, Jurriën M.
Abstract: Background: Patients with acute coronary syndrome (ACS) who are carrying CYP2C19 loss-of-function alleles derive less benefit from clopidogrel treatment. Despite this, in elderly patients, clopidogrel might be preferred over more potent P2Y12 inhibitors due to a lower bleeding risk. Whether CYP2C19 genotype-guided antiplatelet treatment in the elderly could be of benefit has not been studied specifically. Methods: Patients aged 70 years and older with known CYP2C19*2 and *3 genotype were identified from the POPular Genetics and POPular Age trials. Noncarriers of loss-of-function alleles treated with clopidogrel were compared to patients, irrespective of CYP2C19 genotype, treated with ticagrelor and to clopidogrel treated carriers of loss-of-function alleles. We assessed net clinical benefit (all-cause death, myocardial infarction, stroke and Platelet Inhibition and Patient Outcomes (PLATO) major bleeding), atherothrombotic outcomes (cardiovascular death, myocardial infarction, stroke) and bleeding outcomes (PLATO major and minor bleeding). Results: A total of 991 patients were assessed. There was no significant difference in net clinical benefit (17.2% vs. 15.1%, adjusted hazard ratio (adjHR) 1.05, 95% confidence interval (CI) 0.77–1.44), atherothrombotic outcomes (9.7% vs. 9.2%, adjHR 1.00, 95%CI 0.66–1.50), and bleeding outcomes (17.7% vs. 19.8%, adjHR 0.80, 95%CI 0.62–1.12) between clopidogrel in noncarriers of loss-of-function alleles and ticagrelor respectively. Conclusion: In ACS patients aged 70 years and older, there was no significant difference in net clinical benefit and atherothrombotic outcomes between noncarriers of a loss-of-function allele treated with clopidogrel and patients treated with ticagrelor. The bleeding rate was numerically; though not statistically significant, lower in patients using clopidogrel.
Published: 2021

26. Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients

Author: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Claassens, Daniel M.F., Gimbel, Marieke E., Bergmeijer, Thomas O., Vos, Gerrit J.A., Hermanides, Renicus S., van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M., de Vrey, Evelyn A., Heestermans, Ton A.C.M., Jukema, J. Wouter, von Birgelen, Clemens, Waalewijn, Reinier A., Hofma, Sjoerd H., den Hartog, Frank R., Voskuil, Michiel, van't Hof, Arnoud W.J., Asselbergs, Folkert W., Mosterd, A., Herrman, Jean Paul R., Dewilde, Willem, Mahmoodi, Bakhtawar K., Deneer, Vera H.M., ten Berg, Jurriën M., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Claassens, Daniel M.F., Gimbel, Marieke E., Bergmeijer, Thomas O., Vos, Gerrit J.A., Hermanides, Renicus S., van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M., de Vrey, Evelyn A., Heestermans, Ton A.C.M., Jukema, J. Wouter, von Birgelen, Clemens, Waalewijn, Reinier A., Hofma, Sjoerd H., den Hartog, Frank R., Voskuil, Michiel, van't Hof, Arnoud W.J., Asselbergs, Folkert W., Mosterd, A., Herrman, Jean Paul R., Dewilde, Willem, Mahmoodi, Bakhtawar K., Deneer, Vera H.M., and ten Berg, Jurriën M.
Published: 2021

27. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, and van Royen, Niels
Published: 2021

28. Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients

Author: Circulatory Health, Team Medisch, Apotheek Klinische Farmacie, UMC Utrecht, Claassens, Daniel M F, Gimbel, Marieke E, Bergmeijer, Thomas O, Vos, Gerrit J A, Hermanides, Renicus S, van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M, de Vrey, Evelyn A, Heestermans, Ton A C M, Jukema, J Wouter, von Birgelen, Clemens, Waalewijn, Reinier A, Hofma, Sjoerd H, den Hartog, Frank R, Voskuil, Michiel, Van't Hof, Arnoud W J, Asselbergs, Folkert W, Mosterd, A, Herrman, Jean-Paul R, DeWilde, Willem, Mahmoodi, Bakhtawar K, Deneer, Vera H M, Ten Berg, Jurriën M, Circulatory Health, Team Medisch, Apotheek Klinische Farmacie, UMC Utrecht, Claassens, Daniel M F, Gimbel, Marieke E, Bergmeijer, Thomas O, Vos, Gerrit J A, Hermanides, Renicus S, van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M, de Vrey, Evelyn A, Heestermans, Ton A C M, Jukema, J Wouter, von Birgelen, Clemens, Waalewijn, Reinier A, Hofma, Sjoerd H, den Hartog, Frank R, Voskuil, Michiel, Van't Hof, Arnoud W J, Asselbergs, Folkert W, Mosterd, A, Herrman, Jean-Paul R, DeWilde, Willem, Mahmoodi, Bakhtawar K, Deneer, Vera H M, and Ten Berg, Jurriën M
Published: 2021

29. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, and van Royen, Niels
Published: 2021

30. Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial

Author: van't Hof, Arnoud WJ, ten Berg, Jurriën, Heestermans, Ton, Dill, Thorsten, Funck, Reinhard C, van Werkum, Wouter, Dambrink, Jan-Henk E, Suryapranata, Harry, van Houwelingen, Gert, Ottervanger, Jan Paul, Stella, Pieter, Giannitsis, Evangelos, and Hamm, Christian
Published: 2008
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31. TARGETED TEMPERATURE MANAGEMENT IN OHCA WITH SHOCKABLE RHYTHM AND ABSENCE OF ST-SEGMENT ELEVATION: A SUBSTUDY OF THE COACT TRIAL

Author: Spoormans, Eva Marie, primary, Lemkes, Jorrit, additional, Janssens, Gladys, additional, van der Hoeven, Nina, additional, Jewbali, Lucia, additional, Meuwissen, Martijn, additional, Bosker, Hans, additional, Bleeker, Gabe, additional, Vlachojannis, Georgios, additional, van der Harst, Pim, additional, Voskuil, Michiel, additional, Beishuizen, Albertus, additional, Camaro, Cyril, additional, Henriques, José, additional, Vink, Maarten, additional, Heestermans, Ton, additional, Delnoij, Thijs, additional, Jessurun, Gillian, additional, Oemrawsingh, Pranobe, additional, Gosselink, Marcel, additional, Plomp, Koos, additional, Magro, Michael, additional, van de Ven, Peter, additional, Van Royen, Niels, additional, and Elbers, Paul, additional
Published: 2021
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32. Ticagrelor Versus Clopidogrel in Older Patients with NSTE-ACS Using Oral Anticoagulation: A Sub-Analysis of the POPular Age Trial

Author: Gimbel, Marieke E, Tavenier, Anne H, Bor, Wilbert, Hermanides, Renicus S, de Vrey, Evelyn, Heestermans, Ton, Gin, Melvyn Tjon Joe, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology
Subjects: Acute coronary syndrome, medicine.medical_specialty, lcsh:Medicine, 030204 cardiovascular system & hematology, elderly, Article, ticagrelor, 03 medical and health sciences, 0302 clinical medicine, Older patients, non-vitamin K oral anticoagulation (NOAC), vitamin K antagonists (VKA), Internal medicine, medicine, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Stroke, Oral anticoagulation, clopidogrel, business.industry, lcsh:R, General Medicine, medicine.disease, Clopidogrel, non-ST-segment elevation myocardial infarction (NSTEMI), business, Ticagrelor, Nste acs, medicine.drug
Abstract: There are no randomised data on which antiplatelet agent to use in elderly patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and an indication for oral anticoagulation (OAC). The randomised POPular Age trial, in patients of 70 years or older with NSTE-ACS, showed a reduction in bleeding without increasing thrombotic events in patients using clopidogrel as compared to ticagrelor. In this sub-analysis of the POPular AGE trial, we compare clopidogrel with ticagrelor in patients with a need for oral anticoagulation. The follow-up duration was one year. The primary bleeding outcome was Platelet Inhibition and Patient Outcomes (PLATO) major and minor bleeding. The primary thrombotic outcome consisted of cardiovascular death, myocardial infarction and stroke. The primary net clinical benefit outcome was a composite of all-cause death, myocardial infarction, stroke, and PLATO major and minor bleeding. A total of 184/1011 (18.2%) patients on OAC were included in this subanalysis, 83 were randomized to clopidogrel and 101 to ticagrelor. The primary bleeding outcome was lower in the clopidogrel group (17/83, 20.9%) compared to the ticagrelor group (33/101, 33.5%, p = 0.051), as was the thrombotic outcome (7/83, 8.4% vs. 19/101, 19.2%, p = 0.035) and the primary net clinical benefit outcome (23/83, 27.7% vs. 49/101, 48.5%, p = 0.003). In this subgroup of patients using OAC, clopidogrel reduced PLATO major and minor bleeding compared to ticagrelor without increasing thrombotic risk. This analysis therefore suggests that, in line with the POPular Age trial, clopidogrel is a better option than ticagrelor in NSTE-ACS patients &ge, 70 years using OAC.
Published: 2020

33. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial

Author: Gimbel, Marieke, Qaderdan, Khalid, Willemsen, Laura, Hermanides, Rik, Bergmeijer, Thomas, de Vrey, Evelyn, Heestermans, Ton, Tjon Joe Gin, Melvyn, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology
Subjects: Male, Ticagrelor, medicine.medical_specialty, Acute coronary syndrome, Platelet Aggregation Inhibitors/adverse effects, Prasugrel, Myocardial Infarction, 030204 cardiovascular system & hematology, Clopidogrel/adverse effects, law.invention, 03 medical and health sciences, 0302 clinical medicine, P2Y12, Acute Coronary Syndrome/drug therapy, Randomized controlled trial, law, Internal medicine, 80 and over, medicine, Humans, 030212 general & internal medicine, Acute Coronary Syndrome, Stroke/prevention & control, Aged, Aged, 80 and over, Maintenance dose, business.industry, General Medicine, medicine.disease, Clopidogrel, Prasugrel Hydrochloride/adverse effects, Discontinuation, Stroke, Ticagrelor/adverse effects, Myocardial Infarction/prevention & control, Female, business, Prasugrel Hydrochloride, Platelet Aggregation Inhibitors, medicine.drug
Abstract: Summary Background Current guidelines recommend potent platelet inhibition with ticagrelor or prasugrel in patients after an acute coronary syndrome. However, data about optimal platelet inhibition in older patients are scarce. We aimed to investigate the safety and efficacy of clopidogrel compared with ticagrelor or prasugrel in older patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods We did the open-label, randomised controlled POPular AGE trial in 12 sites (ten hospitals and two university hospitals) in the Netherlands. Patients aged 70 years or older with NSTE-ACS were enrolled and randomly assigned in a 1:1 ratio using an internet-based randomisation procedure with block sizes of six to receive a loading dose of clopidogrel 300 mg or 600 mg, or ticagrelor 180 mg or prasugrel 60 mg, and then a maintenance dose for the duration of 12 months (clopidogrel 75 mg once daily, ticagrelor 90 mg twice daily, or prasugrel 10 mg once daily) on top of standard care. Patient and treating physicians were aware of the allocated treatment strategy, but the outcome assessors were masked to treatment allocation. Primary bleeding outcome consisted of PLATelet inhibition and patient Outcomes (PLATO; major or minor bleeding [superiority hypothesis]). Co-primary net clinical benefit outcome consisted of all-cause death, myocardial infarction, stroke, PLATO major and minor bleeding (non-inferiority hypothesis, margin of 2%). Follow-up duration was 12 months. Analyses were done on intention-to-treat basis. This trial is registered with the Netherlands Trial Register (NL3804), ClinicalTrials.gov ( NCT02317198 ), and EudraCT (2013–001403–37). Findings Between June 10, 2013, and Oct 17, 2018, 1002 patients were randomly assigned to clopidogrel (n=500) or ticagrelor or prasugrel (n=502). Because 475 (95%) patients received ticagrelor in the ticagrelor or prasugrel group, we will refer to this group as the ticagrelor group. Premature discontinuation of the study drug occurred in 238 (47%) of 502 ticagrelor group patients randomly assigned to ticagrelor, and in 112 (22%) of 500 patients randomly assigned to clopidogrel. Primary bleeding outcome was significantly lower in the clopidogrel group (88 [18%] of 500 patients) than in the ticagrelor group (118 [24%] of 502; hazard ratio 0·71, 95% CI 0·54 to 0·94; p=0·02 for superiority). Co-primary net clinical benefit outcome was non-inferior for the use of clopidogrel (139 [28%]) versus ticagrelor (161 [32%]; absolute risk difference −4%, 95% CI −10·0 to 1·4; p=0·03 for non-inferiority). The most important reasons for discontinuation were occurrence of bleeding (n=38), dyspnoea (n=40), and the need for treatment with oral anticoagulation (n=35). Interpretation In patients aged 70 years or older presenting with NSTE-ACS, clopidogrel is a favourable alternative to ticagrelor, because it leads to fewer bleeding events without an increase in the combined endpoint of all-cause death, myocardial infarction, stroke, and bleeding. Clopidogrel could be an alternative P2Y12 inhibitor especially for elderly patients with a higher bleeding risk. Funding ZonMw.
Published: 2020

34. Ticagrelor Versus Clopidogrel in Older Patients with NSTE-ACS Using Oral Anticoagulation: A Sub-Analysis of the POPular Age Trial

Author: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Gimbel, Marieke E, Tavenier, Anne H, Bor, Wilbert, Hermanides, Renicus S, de Vrey, Evelyn, Heestermans, Ton, Gin, Melvyn Tjon Joe, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Gimbel, Marieke E, Tavenier, Anne H, Bor, Wilbert, Hermanides, Renicus S, de Vrey, Evelyn, Heestermans, Ton, Gin, Melvyn Tjon Joe, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, and Ten Berg, Jurriën M
Published: 2020

35. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial

Author: Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Gimbel, Marieke, Qaderdan, Khalid, Willemsen, Laura, Hermanides, Rik, Bergmeijer, Thomas, de Vrey, Evelyn, Heestermans, Ton, Tjon Joe Gin, Melvyn, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Gimbel, Marieke, Qaderdan, Khalid, Willemsen, Laura, Hermanides, Rik, Bergmeijer, Thomas, de Vrey, Evelyn, Heestermans, Ton, Tjon Joe Gin, Melvyn, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, and Ten Berg, Jurriën
Published: 2020

36. Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation

Author: Cardiologie Arts-onderzoekers, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., van de Ven, Peter M., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Jessurun, Gillian A.J., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., Appelman, Yolande, van Royen, Niels, Cardiologie Arts-onderzoekers, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M., Lemkes, Jorrit S., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S.D., Dubois, Eric A., van de Ven, Peter M., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Remon, Vlachojannis, Georgios J., Eikemans, Bob J.W., van der Harst, Pim, van der Horst, Iwan C.C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P.J., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A.C.M., de Ruijter, Wouter, Delnoij, Thijs S.R., Crijns, Harry J.G.M., Jessurun, Gillian A.J., Oemrawsingh, Pranobe V., Gosselink, Marcel T.M., Plomp, Koos, Magro, Michael, Elbers, Paul W.G., Appelman, Yolande, and van Royen, Niels
Published: 2020

37. Ticagrelor Versus Clopidogrel in Older Patients with NSTE-ACS Using Oral Anticoagulation: A Sub-Analysis of the POPular Age Trial

Author: Team Medisch, Circulatory Health, Apotheek Klinische Farmacie, Gimbel, Marieke E, Tavenier, Anne H, Bor, Wilbert, Hermanides, Renicus S, de Vrey, Evelyn, Heestermans, Ton, Gin, Melvyn Tjon Joe, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën M, Team Medisch, Circulatory Health, Apotheek Klinische Farmacie, Gimbel, Marieke E, Tavenier, Anne H, Bor, Wilbert, Hermanides, Renicus S, de Vrey, Evelyn, Heestermans, Ton, Gin, Melvyn Tjon Joe, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, and Ten Berg, Jurriën M
Published: 2020

38. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial

Author: Global Health, Team Medisch, Circulatory Health, Apotheek Klinische Farmacie, Gimbel, Marieke, Qaderdan, Khalid, Willemsen, Laura, Hermanides, Rik, Bergmeijer, Thomas, de Vrey, Evelyn, Heestermans, Ton, Tjon Joe Gin, Melvyn, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, Ten Berg, Jurriën, Global Health, Team Medisch, Circulatory Health, Apotheek Klinische Farmacie, Gimbel, Marieke, Qaderdan, Khalid, Willemsen, Laura, Hermanides, Rik, Bergmeijer, Thomas, de Vrey, Evelyn, Heestermans, Ton, Tjon Joe Gin, Melvyn, Waalewijn, Reinier, Hofma, Sjoerd, den Hartog, Frank, Jukema, Wouter, von Birgelen, Clemens, Voskuil, Michiel, Kelder, Johannes, Deneer, Vera, and Ten Berg, Jurriën
Published: 2020

39. One Year Outcomes of Coronary Angiography After Cardiac Arrest

Author: Lemkes, Jorrit, Janssens, Gladys, van der Hoeven, Nina, Jewbali, Lucia, Dubois, Eric, Meuwissen, Martijn, Rijpstra, Tom, Bosker, Hans, Blans, Michiel, Bleeker, Gabe, Baak, Remon, Vlachojannis, Georgios, Eikemans, Bob, van der Harst, Pim, van der Horst, Iwan, Voskuil, Michiel, van der Heijden, Joris, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, Jose, Vlaar, Alexander, Vink, Maarten, Heestermans, Ton, Delnoij, Thijs, Jessurun, Gillian, Oemrawsingh, Pranobe, Gosselink, Marcel, Plomp, Koos, Magro, Michael, Elbers, Paul, van de Ven, Peter, Oudemans-van Straaten, Heleen, van Royen, Niels, Cardiology, Intensive care medicine, APH - Methodology, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, ACS - Diabetes & metabolism, and ACS - Atherosclerosis & ischemic syndromes
Published: 2019

40. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author: Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, van de Ven, Peter M., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, der Harst, Pim van, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Jessurun, Gillian A.J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, Appelman, Yolande, additional, and van Royen, Niels, additional
Published: 2021
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41. Coronary Angiography After Cardiac Arrest Without ST Segment Elevation

Author: Lemkes, Jorrit S., primary, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S. D., additional, Dubois, Eric A., additional, Meuwissen, Martijn M., additional, Rijpstra, Topm A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon R., additional, Vlachojannis, George J., additional, Eikemans, Bob J. W., additional, van der Harst, Pim, additional, van der Horst, Iwan C. C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, Jose P., additional, Vlaar, Alexander P. J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A. C. M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S. R., additional, Crijns, Harry J. G. M., additional, Jessurun, Gillian A. J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T. M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W. G., additional, Spoormans, Eva M., additional, van de Ven, Peter M., additional, Oudemans-van Straaten, Heleen M., additional, and van Royen, Niels, additional
Published: 2020
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42. Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation

Author: Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, van de Ven, Peter M., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, van der Harst, Pim, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Jessurun, Gillian A.J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, Appelman, Yolande, additional, and van Royen, Niels, additional
Published: 2020
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43. Prehospital triple antiplatelet therapy in patients with acute ST elevation myocardial infarction leads to better platelet aggregation inhibition and clinical outcome than dual antiplatelet therapy

Author: Smit, Jaap Jan J, van Werkum, Jochem W, ten Berg, Jurrien, Slingerland, Robbert, Ottervanger, Jan Paul, Heestermans, Ton, Dill, Thorsten, Hamm, Christian, and van ʼt Hof, Arnoud W J
Published: 2010
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44. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Author: Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, van Royen, Niels, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, and van Royen, Niels
Published: 2019

45. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Author: Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, Oudemans-van Straaten, Heleen M, and van Royen, Niels
Published: 2019

46. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Author: Lemkes, Jorrit S., primary, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S.D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Rémon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J.W., additional, van der Harst, Pim, additional, van der Horst, Iwan C.C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P.J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A.C.M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S.R., additional, Crijns, Harry J.G.M., additional, Jessurun, Gillian A.J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T.M., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W.G., additional, van de Ven, Peter M., additional, Oudemans-van Straaten, Heleen M., additional, and van Royen, Niels, additional
Published: 2019
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47. Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis

Author: Adriaenssens, Tom, Joner, Michael, Godschalk, Thea C., Malik, Nikesh, Alfonso, Fernando, Xhepa, Erion, De Cock, Dries, Komukai, Kenichi, Tada, Tomohisa, Cuesta, Javier, Sirbu, Vasile, Feldman, Laurent J., Neumann, Franz-Josef, Goodall, Alison H., Heestermans, Ton, Buysschaert, Ian, Hlinomaz, Ota, Belmans, Ann, Desmet, Walter, ten Berg, Jurrien M., Gershlick, Anthony H., Massberg, Steffen, Kastrati, Adnan, Guagliumi, Giulio, and Byrne, Robert A.
Subjects: ddc
Published: 2017

48. A clinical risk score to identify patients at high risk of very late stent thrombosis

Author: Godschalk, Thea C., primary, Gimbel, Marieke E., additional, Nolet, Wouter W., additional, van Kessel, Dionne J., additional, Amoroso, Giovanni, additional, Dewilde, Willem J., additional, Wykrzykowska, Joanna J., additional, Janssen, Paul W., additional, Bergmeijer, Thomas O., additional, Kelder, Johannes C., additional, Heestermans, Ton, additional, and ten Berg, Jurriën M., additional
Published: 2018
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49. Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

Author: Montalescot, Gilles, primary, van ’t Hof, Arnoud W., additional, Bolognese, Leonardo, additional, Cantor, Warren J., additional, Cequier, Angel, additional, Chettibi, Mohamed, additional, Collet, Jean-Philippe, additional, Goodman, Shaun G., additional, Hammett, Christopher J., additional, Huber, Kurt, additional, Janzon, Magnus, additional, Lapostolle, Frédéric, additional, Lassen, Jens Flensted, additional, Licour, Muriel, additional, Merkely, Béla, additional, Salhi, Néjoua, additional, Silvain, Johanne, additional, Storey, Robert F., additional, ten Berg, Jurriën M., additional, Tsatsaris, Anne, additional, Zeymer, Uwe, additional, Vicaut, Eric, additional, Hamm, Christian W., additional, Bougherbal, Rachid, additional, Bouafia, Mohamed Tahar, additional, Nibouche, Djamaleddine, additional, Moklati, Abdelkader, additional, Benalia, Ahmed, additional, Kaid, Omar, additional, Krim, Messaad, additional, Hammett, Christopher, additional, Garrahy, Paul, additional, Jayasinghe, Rohan, additional, Rashford, Stephen, additional, Neunteufl, Thomas, additional, Brussee, Helmut, additional, Alber, Hannes, additional, Weidinger, Franz, additional, Brunner, Michael, additional, Sipoetz, Johann, additional, Prause, Gerhard, additional, Baubin, Michael, additional, Sebald, Dieter, additional, Cantor, Warren, additional, Vijayaraghavan, Ram, additional, Bata, Iqbal, additional, Lavoie, Andrea, additional, Ravkilde, Jan, additional, Jensen, Lisette Okkels, additional, Christensen, Alf Møl, additional, Toftegaard, Marianne, additional, Köhler, Dennis, additional, Montalescot, Gilles, additional, Ducrocq, Gregory, additional, Danchin, Nicolas, additional, Henry, Patrick, additional, Livarek, Bernard, additional, Berthier, Romain, additional, Hovasse, Thomas, additional, Garot, Philippe, additional, Payot, Laurent, additional, Benamer, Hakim, additional, Esteve, Jean Baptiste, additional, Elhadad, Simon, additional, Teiger, Emmanuel, additional, Bonnet, Jean Louis, additional, Paganelli, Franck, additional, Cottin, Yves, additional, Schiele, François, additional, Thuaire, Christophe, additional, Cayla, Guillaume, additional, Coste, Pierre, additional, Ohlmann, Patrick, additional, Cudraz, Eric Bonnefoy, additional, Lantelme, Pierre, additional, Perret, Thibault, additional, Tron, Christophe, additional, De Labriolle, Axel, additional, Aptecar, Edouardo, additional, Beliard, Olivier, additional, Varenne, Olivier, additional, El Mahmoud, Rami, additional, Filippi-Codaccioni, Emmanuelle, additional, Angoulvant, Denis, additional, Peycher, Patrick, additional, Poitrineau, Olivier, additional, Tabone, Xavier, additional, Ecollan, Patrick, additional, Broche, Claire, additional, Lambert, Yves, additional, Briole, Nicolas, additional, Beruben, Arielle, additional, Porcher, Nicolas, additional, Auffray, Jean-Pierre, additional, Freysz, Marc, additional, Depardieu, Franck, additional, Poubel, David, additional, De La Cousaye, Jean-Emmanuel, additional, Bartier, Jean-Claude, additional, Jardel, Benoît, additional, Boulanger, Bertrand, additional, Labourel, Hervé, additional, Soulat, Louis-Christophe, additional, Julie, Véronique, additional, Thicoipe, Michel, additional, Capel, Olivier, additional, Stibbe, Olivier, additional, Carli, Pierre, additional, Tazarourte, Karim, additional, Alcouffe, Fabrice, additional, Aboucaya, David, additional, Aubert, Gaële, additional, Kierzek, Gérald, additional, Cahun-Giraud, Séverine, additional, Hamm, Christian, additional, Dengler, Thomas, additional, Prondzinsky, Roland, additional, Biever, Paul Marc, additional, Schäfer, Andreas, additional, Seyfarth, Melchior, additional, Lemke, Bernd, additional, Werner, Gerald, additional, Nef, Holger, additional, Steiger, Holger, additional, Leschke, Matthias, additional, Münzel, Thomas, additional, Dell Orto, Marco Campo, additional, Loges, Christian, additional, Schinke, Monika, additional, Koberne, Frank, additional, Reiffen, Hans Peter, additional, Tiroch, Klaus, additional, Wierich, Dirk, additional, Kneussel, Michael, additional, Little, Simon, additional, Sauer, Hartmut, additional, Laufenberg-Feldmann, Rita, additional, Ungi, Imre, additional, Horváth, Iván, additional, Édes, István, additional, Mártai, István, additional, Berti, Sergio, additional, Chiarella, Francesco, additional, Calabria, Paolo, additional, Fineschi, Massimo, additional, Galvani, Marcello, additional, Valgimigli, Marco, additional, Moretti, Luciano, additional, Tespili, Maurizio, additional, Mandó, Massimo, additional, Bermano, Francesco, additional, Biagioni, Robusto, additional, Fabbri, Andrea, additional, Ricciardelli, Adelina, additional, Petroni, Maria Romana, additional, Vatteroni, Umberto Roberto, additional, Palumbo, Francesco, additional, Willems, Frank F., additional, Al Mafragi, Amar, additional, Heestermans, Ton A.A.C.M., additional, Van Eck, Martijn J., additional, Heutz, Wim M.J.M., additional, Meppelder, H.H., additional, Jong, Anika Roukema-de, additional, Van de Pas, Harm, additional, Fillat, Ángel Cequier, additional, Tenas, Manel Sabaté, additional, Ferrer, Josepa Mauri, additional, Peñaranda, Antoni Serra, additional, Ferrer, Joan Ángel, additional, Del Blanco, Bruno García, additional, Guardiola, Faustino Miranda, additional, Ruiz Nodar, Juan Miguel, additional, Romo, Andrés Íñiguez, additional, González, Nicolás Vázquez, additional, Nouche, Ramiro Trillo, additional, De La Llera, Luis Díaz, additional, Hernández García, José María, additional, Rivero-Crespo, Fernando, additional, Hernández, Felipe Hernández, additional, Zamorano Gómez, José Luis, additional, Fárega, Xavier Jiménez, additional, Fernández, Gilberto Alonso, additional, Toboso, José Luis, additional, Carrasco, Mercedes, additional, Barreiro, Victoria, additional, Iglesias Vázquez, José Antonio, additional, Montero, María del Mar Ruiz, additional, Ortiz, Fernando Rosell, additional, Escudero, Guillermo Garcia, additional, Ingelmo, Vicente Sánchez-Brunete, additional, García, Antonio Lara, additional, Oldgren, Jonas, additional, Calais, Fredrik, additional, Kastberg, Robert, additional, Bergsten, Per-Adolf, additional, Blomberg, Hans, additional, Thörn, Kristian, additional, Skoog, Gunnar, additional, Zaman, Azfar, additional, Gerber, Robert, additional, Ryding, Alisdair, additional, Spence, Mark, additional, Swanson, Neil, additional, Been, Martin, additional, Grosser, Konrad, additional, Schofield, Peter, additional, Mackin, David, additional, Fell, Paul, additional, Quinn, Tom, additional, Foster, Teresa, additional, McManus, David, additional, and Carson, Andy, additional
Published: 2016
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50. PREDICTIVE VALUE OF VARIOUS PLATELET FUNCTION TESTS ON ST-SEGMENT RESOLUTION AND CLINICAL OUTCOME IN STEMI PATIENTS RANDOMIZED TO EITHER DUAL OR TRIPLE ANTIPLATELET THERAPY: THE ONTIME2 PLATELET FUNCTION SUBSTUDY

Author: Bouman, Heleen J., van Werkum, Jochem W., Smit, Jaap J., Breet, Nicoline J., Postma, Sonja, Heestermans, Ton, ten Berg, Jurriën M., Slingerland, Robbert, Hackeng, Christian M., Hamm, Christian, van ‘t Hof, Arnoud, and Ongoing in Tirofiban in Myocardial Infarction Evaluation (ON-TIME) trial investigators
Subjects: medicine.medical_specialty, Platelet function test, business.industry, Internal medicine, medicine, Cardiology, ST segment, Platelet, cardiovascular diseases, business, Cardiology and Cardiovascular Medicine, Predictive value
Published: 2010
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