Search

Your search keyword '"Heestand, G."' showing total 42 results
Start Over Author "Heestand, G."
42 results on '"Heestand, G."'

4. Demonstration of high-energy 2[omega] (526.5 nm) operation on the National Ignition Facility Laser System

Author

Heestand, G. M., Haynam, C. A., Wegner, P. J., Bowers, M. W., Dixit, S. N., Erbert, G. V., Henesian, M. A., Hermann, M. R., Jancaitis, K. S., Knittel, K., Kohut, T., Lindl, J. D., Manes, K. R., Marshall, C. D., Mehta, N. C., Menapace, J., Moses, E., Murray, J. R., Nostrand, M. C., Orth, C. D., Patterson, R., Sacks, R. A., Saunders, R., Shaw, M. J., Spaeth, M., Sutton, S. B., Williams, W. H., Widmayer, C. C., White, R. K., Whitman, P. K., Yang, S. T., and Van Wonterghem, B. M.

Subjects
Laser beams -- Properties, Frequency converters -- Research, Astronomy, Physics
Abstract

A single beamline of the National Ignition Facility (NIF) has been operated at a wavelength of 526.5 nm (2[omega]) by frequency converting the fundamental 1053 nm (l[omega]) wavelength with an 18.2 mm thick type-I potassium dihydrogen phosphate (KDP) second-harmonic generator (SHG) crystal. Second-harmonic energies of up to 17.9 kJ were measured at the final optics focal plane with a conversion efficiency of 82%. For a similarly configured 192-beam NIF, this scales to a total 2w energy of 3.4 MJ full NIF equivalent (FNE). OCIS codes: 140.0140, 140.3070, 140.3515, 140.3530.

Published
2008

5. The first target experiments on the National Ignition Facility

Author

Landen, O. L., Glenzer, S. H., Froula, D. H., Dewald, E. L., Suter, L. J., Schneider, M. B., Hinkel, D. E., Fernandez, J. C., Kline, J. L., Goldman, S. R., Braun, D. G., Celliers, P. M., Moon, S. J., Robey, H. S., Lanier, N. E., Glendinning, S. G., Blue, B. E., Wilde, B. H., Jones, O. S., Schein, J., Divol, L., Kalantar, D. H., Campbell, K. M., Holder, J. P., McDonald, J. W., Niemann, C., Mackinnon, A. J., Collins, G. W., Bradley, D. K., Eggert, J. H., Hicks, D. G., Gregori, G., Kirkwood, R. K., Young, B. K., Foster, J. M., Hansen, J. F., Perry, T. S., Munro, D. H., Baldis, H. A., Grim, G. P., Heeter, R. F., Hegelich, M. B., Montgomery, D. S., Rochau, G. A., Olson, R. E., Turner, R. E., Workman, J. B., Berger, R. L., Cohen, B. I., Kruer, W. L., Langdon, A. B., Langer, S. H., Meezan, N. B., Rose, H. A., Still, C. H., Williams, E. A., Dodd, E. S., Edwards, M. J., Monteil, M.-C., Stevenson, R. M., Thomas, B. R., Coker, R. F., Magelssen, G. R., Rosen, P. A., Stry, P. E., Woods, D., Weber, S. V., Young, P. E., Alvarez, S., Armstrong, G., Bahr, R., Bourgade, J.-L., Bower, D., Celeste, J., Chrisp, M., Compton, S., Cox, J., Constantin, C., Costa, R., Duncan, J., Ellis, A., Emig, J., Gautier, C., Greenwood, A., Griffith, R., Holdner, F., Holtmeier, G., Hargrove, D., James, T., Kamperschroer, J., Kimbrough, J., Landon, M., Lee, F. D., Malone, R., May, M., Montelongo, S., Moody, J., Ng, E., Nikitin, A., Pellinen, D., Piston, K., Poole, M., Rekow, V., Rhodes, M., Shepherd, R., Shiromizu, S., Voloshin, D., Warrick, A., Watts, P., Weber, F., Young, P., Arnold, P., Atherton, L., Bardsley, G., Bonanno, R., Borger, T., Bowers, M., Bryant, R., Buckman, S., Burkhart, S., Cooper, F., Dixit, S. N., Erbert, G., Eder, D. C., Ehrlich, R. E., Felker, B., Fornes, J., Frieders, G., Gardner, S., Gates, C., Gonzalez, M., Grace, S., Hall, T., Haynam, C. A., Heestand, G., Henesian, M. A., Hermann, M., Hermes, G., Huber, S., Jancaitis, K., Johnson, S., Kauffman, B., Kelleher, T., Kohut, T., Koniges, A. E., Labiak, T., Latray, D., Lee, A., Lund, D., Mahavandi, S., Manes, K. R., Marshall, C., McBride, J., McCarville, T., McGrew, L., Menapace, J., Mertens, E., Murray, J., Neumann, J., Newton, M., Opsahl, P., Padilla, E., Parham, T., Parrish, G., Petty, C., Polk, M., Powell, C., Reinbachs, I., Rinnert, R., Riordan, B., Ross, G., Robert, V., Tobin, M., Sailors, S., Saunders, R., Schmitt, M., Shaw, M., Singh, M., Spaeth, M., Stephens, A., Tietbohl, G., Tuck, J., Van Wonterghem, B. M., Vidal, R., Wegner, P. J., Whitman, P., Williams, K., Winward, K., Work, K., Wallace, R., Nobile, A., Bono, M., Day, B., Elliott, J., Hatch, D., Louis, H., Manzenares, R., O'Brien, D., Papin, P., Pierce, T., Rivera, G., Ruppe, J., Sandoval, D., Schmidt, D., Valdez, L., Zapata, K., MacGowan, B. J., Eckart, M. J., Hsing, W. W., Springer, P. T., Hammel, B. A., Moses, E. I., and Miller, G. H.

Published
2007
Full Text
View/download PDF

7. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma

Author

Ikeda, S, Tsigelny, IF, Skjevik, AA, Kono, Y, Mendler, M, Kuo, A, Sicklick, JK, Heestand, G, Banks, KC, Talasaz, A, Lanman, RB, Lippman, S, and Kurzrock, R

Subjects
Adult, Male, Liver Cancer, Hepatocellular carcinoma, Oncology and Carcinogenesis, Circulating Tumor DNA, Rare Diseases, Clinical Research, Genetics, Humans, Prospective Studies, Oncology & Carcinogenesis, neoplasms, Next‐generation sequencing, Aged, Cancer, Tumor, Liquid biopsy, Liver Disease, Carcinoma, Human Genome, High-Throughput Nucleotide Sequencing, Hepatocellular, Middle Aged, Good Health and Well Being, Next-generation sequencing, Female, Digestive Diseases, Biomarkers
Abstract

BACKGROUND:Because imaging has a high sensitivity to diagnose hepatocellular carcinoma (HCC) and tissue biopsies carry risks such as bleeding, the latter are often not performed in HCC. Blood-derived circulating tumor DNA (ctDNA) analysis can identify somatic alterations, but its utility has not been characterized in HCC. MATERIALS AND METHODS:We evaluated 14 patients with advanced HCC (digital ctDNA sequencing [68 genes]). Mutant relative to wild-type allele fraction was calculated. RESULTS:All patients (100%) had somatic alterations (median = 3 alterations/patient [range, 1-8]); median mutant allele fraction, 0.29% (range, 0.1%-37.77%). Mutations were identified in several genes: TP53 (57% of patients), CTNNB1 (29%), PTEN (7%), CDKN2A (7%), ARID1A (7%), and MET (7%); amplifications, in CDK6 (14%), EGFR (14%), MYC (14%), BRAF (7%), RAF1 (7%), FGFR1 (7%), CCNE1 (7%), PIK3CA (7%), and ERBB2/HER2 (7%). Eleven patients (79%) had ≥1 theoretically actionable alteration. No two patients had identical genomic portfolios, suggesting the need for customized treatment. A patient with a CDKN2A-inactivating and a CTNNB1-activating mutation received matched treatment: palbociclib (CDK4/6 inhibitor) and celecoxib (COX-2/Wnt inhibitor); des-gamma-carboxy prothrombin level decreased by 84% at 2 months (1,410 to 242 ng/mL [normal: ≤7.4 ng/mL]; alpha fetoprotein [AFP] low at baseline). A patient with a PTEN-inactivating and a MET-activating mutation (an effect suggested by in silico molecular dynamic simulations) received sirolimus (mechanistic target of rapamycin inhibitor) and cabozantinib (MET inhibitor); AFP declined by 63% (8,320 to 3,045 ng/mL [normal: 0-15 ng/mL]). CONCLUSION:ctDNA derived from noninvasive blood tests can provide exploitable genomic profiles in patients with HCC. IMPLICATIONS FOR PRACTICE:This study reports that blood-derived circulating tumor DNA can provide therapeutically exploitable genomic profiles in hepatocellular cancer, a malignancy that is known to be difficult to biopsy.

Published
2018

13. Erratum: “Review of the National Ignition Campaign 2009-2012” [Phys. Plasmas 21, 020501 (2014)]

Author

Lindl, J. D., primary, Landen, O. L., additional, Edwards, J., additional, Moses, E. I., additional, Adams, J., additional, Amendt, P. A., additional, Antipa, N., additional, Arnold, P. A., additional, Atherton, L. J., additional, Azevedo, S., additional, Barker, D., additional, Barrios, M. A., additional, Bass, I., additional, Baxamusa, S. H., additional, Beeler, R., additional, Beeman, B. V., additional, Bell, P. M., additional, Benedetti, L. R., additional, Bernstein, L., additional, Berzak Hopkins, L., additional, Bhandarkar, S. D., additional, Biesiada, T., additional, Bionta, R. M., additional, Bleuel, D. L., additional, Bond, E. J., additional, Borden, M., additional, Bowers, M. W., additional, Bradley, D. K., additional, Browning, D., additional, Brunton, G. K., additional, Bude, J., additional, Burkhart, S. C., additional, Burr, R. F., additional, Butlin, B., additional, Caggiano, J. A., additional, Callahan, D. A., additional, Carpenter, A. C., additional, Carr, C. W., additional, Casey, D. T., additional, Castro, C., additional, Celeste, J., additional, Celliers, P. M., additional, Cerjan, C. J., additional, Chang, J., additional, Chiarappa-Zucca, M., additional, Choate, C., additional, Clancy, T. J., additional, Clark, D. S., additional, Cohen, S. J., additional, Collins, G. W., additional, Conder, A., additional, Cox, J. R., additional, Datte, P. S., additional, Deis, G. A., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S. N., additional, Döppner, T., additional, Draggoo, V., additional, Drury, O., additional, Dylla-Spears, R., additional, Dzenitis, E. G., additional, Dzenitis, J. M., additional, Eckart, M. J., additional, Eder, D. C., additional, Eggert, J. H., additional, Ehrlich, R. B., additional, Erbert, G. V., additional, Fair, J., additional, Farley, D. R., additional, Fedorov, M., additional, Felker, B., additional, Finucane, R., additional, Fisher, A., additional, Fittinghoff, D. N., additional, Folta, J., additional, Fortner, R. J., additional, Frazier, T., additional, Frieders, G., additional, Frieders, S., additional, Friedrich, S., additional, Fry, J., additional, Gaylord, J., additional, Glenn, S. M., additional, Glenzer, S. H., additional, Golick, B., additional, Gururangan, G., additional, Guss, G., additional, Haan, S. W., additional, Haid, B. J., additional, Hammel, B., additional, Hamza, A. V., additional, Hartouni, E. P., additional, Hatarik, R., additional, Hatch, B. W., additional, Hatchett, S. P., additional, Hawley, R., additional, Haynam, C., additional, Heebner, J., additional, Heestand, G., additional, Hermann, M. R., additional, Hernandez, V. J., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Ho, D. D., additional, Holder, J. P., additional, Holunga, D., additional, Honig, J., additional, Horner, J., additional, House, R. K., additional, Hutton, M., additional, Izumi, N., additional, Jackson, M. C., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, M. A., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kauffman, R. L., additional, Kegelmeyer, L., additional, Kerbel, G., additional, Key, M., additional, Khan, S. F., additional, Kimbrough, J. R., additional, Kirkwood, R., additional, Klingman, J. J., additional, Koch, J. A., additional, Kohut, T. R., additional, Koning, J. M., additional, Knittel, K. M., additional, Kozioziemski, B. J., additional, Krauter, G. W., additional, Krauter, K., additional, Kritcher, A., additional, Kroll, J., additional, Kruer, W. L., additional, LaCaille, G., additional, LaFortune, K. N., additional, Lagin, L. J., additional, Land, T. A., additional, Langdon, A. B., additional, Langer, S. H., additional, Larson, D. W., additional, Latray, D. A., additional, Laurence, T., additional, LePape, S., additional, Lerche, R. A., additional, Liao, Z., additional, Liebman, J., additional, London, R. A., additional, Lowe-Webb, R. R., additional, Ma, T., additional, MacGowan, B. J., additional, MacKinnon, A. J., additional, MacPhee, A. G., additional, Malsbury, T. N., additional, Manes, K., additional, Manuel, A. M., additional, Mapoles, E. R., additional, Marinak, M. M., additional, Marshall, C. D., additional, Mason, D., additional, Masters, N., additional, Mathisen, D. G., additional, Matthews, I., additional, McCarville, T., additional, McNaney, J. M., additional, Meeker, D. J., additional, Meezan, N. B., additional, Menapace, J., additional, Michel, P., additional, Miller, P. E., additional, Milovich, J. L., additional, Mintz, M., additional, Montesanti, R., additional, Monticelli, M., additional, Moody, J. D., additional, Moran, M. J., additional, Moreno, J. C., additional, Munro, D. H., additional, Negres, R. A., additional, Nelson, J. R., additional, Norton, M., additional, Nostrand, M., additional, O'Brien, M., additional, Opachich, Y. P., additional, Orth, C., additional, Pak, A. E., additional, Palma, E. S., additional, Palmer, J. N. E., additional, Parham, T. G., additional, Park, H.-S., additional, Patel, P. K., additional, Patterson, R. W., additional, Peterson, J. E., additional, Peterson, J. L., additional, Phillips, T., additional, Prasad, R., additional, Primdahl, K., additional, Prisbrey, S. T., additional, Qiu, S. R., additional, Ralph, J. E., additional, Raman, K. S., additional, Ravizza, F., additional, Raymond, B., additional, Remington, B. A., additional, Rever, M. A., additional, Reynolds, J., additional, Richardson, M. J., additional, Riddle, A. C., additional, Rittmann, B., additional, Rosen, M. D., additional, Ross, J. S., additional, Rygg, J. R., additional, Sacks, R. A., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Sater, J. D., additional, Saunders, R. L., additional, Sawicki, R., additional, Schaffers, K., additional, Schneider, D. H., additional, Schneider, M. B., additional, Scott, H. A., additional, Sepke, S. M., additional, Seugling, R., additional, Shaughnessy, D. A., additional, Shaw, M. J., additional, Shelton, R., additional, Shen, N., additional, Shingleton, N., additional, Simanovskaia, N., additional, Smalyuk, V., additional, Smauley, D. A., additional, Spaeth, M., additional, Spears, B. K., additional, Speck, D. R., additional, Spinka, T. M., additional, Springer, P. T., additional, Stadermann, M., additional, Stoeffl, W., additional, Stolken, J., additional, Stolz, C., additional, Storm, E., additional, Strozzi, D. J., additional, Suratwala, T., additional, Suter, L. J., additional, Taylor, J. S., additional, Thomas, C. A., additional, Tietbohl, G. L., additional, Tommasini, R., additional, Trummer, D., additional, VanWonterghem, B., additional, Von Rotz, R., additional, Wallace, R. J., additional, Walters, C. F., additional, Wang, A., additional, Warrick, A. L., additional, Weaver, S., additional, Weber, S. V., additional, Wegner, P. J., additional, Widmann, K., additional, Widmayer, C. C., additional, Williams, E. A., additional, Whitman, P. K., additional, Wilhelmsen, K., additional, Witte, M., additional, Wong, L., additional, Wood, R. D., additional, Yang, S., additional, Yeamans, C., additional, Young, B. K., additional, Yoxall, B., additional, Zacharias, R. A., additional, Zimmerman, G. B., additional, Batha, S., additional, Danly, C. R., additional, Fatherley, V., additional, Grim, G. P., additional, Guler, N., additional, Herrmann, H. W., additional, Kim, Y., additional, Kline, J. L., additional, Kyrala, G. A., additional, Leeper, R. J., additional, Martinson, D., additional, Merrill, F. E., additional, Olson, R. E., additional, Wilde, C., additional, Wilke, M. D., additional, Wilson, D. C., additional, Chandler, G. A., additional, Cooper, G. W., additional, Hahn, K. D., additional, Peterson, K. J., additional, Ruiz, C. L., additional, Chen, K. C., additional, Dorsano, N., additional, Emerich, M., additional, Gibson, C., additional, Hoover, D., additional, Hoppe, M., additional, Kilkenny, J. D., additional, Moreno, K., additional, Wilkens, H., additional, Woods, S., additional, Frenje, J. A., additional, Johnson, M. G., additional, Li, C. K., additional, Petrasso, R. D., additional, Rinderknecht, H., additional, Rosenberg, M., additional, Séguin, F. H., additional, Zylstra, A., additional, Garbett, W., additional, Graham, P., additional, Guymer, T., additional, Moore, A. S., additional, Bourgade, J.-L., additional, Gauthier, P., additional, Leidinger, J.-P., additional, Masse, L., additional, Philippe, F., additional, and Scott, R. H. H., additional

Published
2014
Full Text
View/download PDF

14. Characteristics and management of splenic artery aneurysm in liver transplant candidates and recipients

Author

Heestand, G., Sher, L., Lightfoote, J., Suzanne Palmer, Mateo, R., Singh, G., Moser, J., Selby, R., Genyk, Y., and Jabbour, N.

Subjects
Adult, Liver Cirrhosis, Male, General Medicine, Middle Aged, Aneurysm, Embolization, Therapeutic, Liver Transplantation, Splenectomy, Humans, Female, Tomography, X-Ray Computed, Splenic Artery, Magnetic Resonance Angiography, Aged, Retrospective Studies
Abstract

The incidence of splenic artery aneurysm (SAA) in patients with cirrhosis ranges from 7 per cent to 17 per cent. SAA rupture after liver transplantation (LT) is reported to result in significant morbidity and mortality. We report our experience with SAA in LT candidates. From September 1995 through August 2002, 14 LT candidates were diagnosed with SAA. Twenty SAA occurred in 14 patients with an average diameter of 20 mm. Eleven patients qualified for LT; to date, seven have been transplanted. No intervention for SAA occurred prior to LT. Of the seven patients transplanted, four had SAA identified prior to LT. Three were treated at LT and are alive; the fourth had postoperative splenic artery embolization followed by splenectomy and expired on day 109 from duodenal ulcer complications. Three of seven patients had undiagnosed SAA at LT. One required emergency splenectomy for SAA rupture and is alive at 44 months. The remaining two received no treatment; one suffered a late septic death and one is alive at 15 months. No ruptures occurred in our pre-LT population, suggesting that definitive management can await LT. We recommend that all patients undergo four-phase computed tomography or magnetic resonance angiography (MRA) as part of the LT evaluation and that identified SAA be resected at transplantation.

Published
2003

16. Assembly of High-Areal-Density Deuterium-Tritium Fuel from Indirectly Driven Cryogenic Implosions

Author

Mackinnon, A. J., primary, Kline, J. L., additional, Dixit, S. N., additional, Glenzer, S. H., additional, Edwards, M. J., additional, Callahan, D. A., additional, Meezan, N. B., additional, Haan, S. W., additional, Kilkenny, J. D., additional, Döppner, T., additional, Farley, D. R., additional, Moody, J. D., additional, Ralph, J. E., additional, MacGowan, B. J., additional, Landen, O. L., additional, Robey, H. F., additional, Boehly, T. R., additional, Celliers, P. M., additional, Eggert, J. H., additional, Krauter, K., additional, Frieders, G., additional, Ross, G. F., additional, Hicks, D. G., additional, Olson, R. E., additional, Weber, S. V., additional, Spears, B. K., additional, Salmonsen, J. D., additional, Michel, P., additional, Divol, L., additional, Hammel, B., additional, Thomas, C. A., additional, Clark, D. S., additional, Jones, O. S., additional, Springer, P. T., additional, Cerjan, C. J., additional, Collins, G. W., additional, Glebov, V. Y., additional, Knauer, J. P., additional, Sangster, C., additional, Stoeckl, C., additional, McKenty, P., additional, McNaney, J. M., additional, Leeper, R. J., additional, Ruiz, C. L., additional, Cooper, G. W., additional, Nelson, A. G., additional, Chandler, G. G. A., additional, Hahn, K. D., additional, Moran, M. J., additional, Schneider, M. B., additional, Palmer, N. E., additional, Bionta, R. M., additional, Hartouni, E. P., additional, LePape, S., additional, Patel, P. K., additional, Izumi, N., additional, Tommasini, R., additional, Bond, E. J., additional, Caggiano, J. A., additional, Hatarik, R., additional, Grim, G. P., additional, Merrill, F. E., additional, Fittinghoff, D. N., additional, Guler, N., additional, Drury, O., additional, Wilson, D. C., additional, Herrmann, H. W., additional, Stoeffl, W., additional, Casey, D. T., additional, Johnson, M. G., additional, Frenje, J. A., additional, Petrasso, R. D., additional, Zylestra, A., additional, Rinderknecht, H., additional, Kalantar, D. H., additional, Dzenitis, J. M., additional, Di Nicola, P., additional, Eder, D. C., additional, Courdin, W. H., additional, Gururangan, G., additional, Burkhart, S. C., additional, Friedrich, S., additional, Blueuel, D. L., additional, Bernstein, l. A., additional, Eckart, M. J., additional, Munro, D. H., additional, Hatchett, S. P., additional, Macphee, A. G., additional, Edgell, D. H., additional, Bradley, D. K., additional, Bell, P. M., additional, Glenn, S. M., additional, Simanovskaia, N., additional, Barrios, M. A., additional, Benedetti, R., additional, Kyrala, G. A., additional, Town, R. P. J., additional, Dewald, E. L., additional, Milovich, J. L., additional, Widmann, K., additional, Moore, A. S., additional, LaCaille, G., additional, Regan, S. P., additional, Suter, L. J., additional, Felker, B., additional, Ashabranner, R. C., additional, Jackson, M. C., additional, Prasad, R., additional, Richardson, M. J., additional, Kohut, T. R., additional, Datte, P. S., additional, Krauter, G. W., additional, Klingman, J. J., additional, Burr, R. F., additional, Land, T. A., additional, Hermann, M. R., additional, Latray, D. A., additional, Saunders, R. L., additional, Weaver, S., additional, Cohen, S. J., additional, Berzins, L., additional, Brass, S. G., additional, Palma, E. S., additional, Lowe-Webb, R. R., additional, McHalle, G. N., additional, Arnold, P. A., additional, Lagin, L. J., additional, Marshall, C. D., additional, Brunton, G. K., additional, Mathisen, D. G., additional, Wood, R. D., additional, Cox, J. R., additional, Ehrlich, R. B., additional, Knittel, K. M., additional, Bowers, M. W., additional, Zacharias, R. A., additional, Young, B. K., additional, Holder, J. P., additional, Kimbrough, J. R., additional, Ma, T., additional, La Fortune, K. N., additional, Widmayer, C. C., additional, Shaw, M. J., additional, Erbert, G. V., additional, Jancaitis, K. S., additional, DiNicola, J. M., additional, Orth, C., additional, Heestand, G., additional, Kirkwood, R., additional, Haynam, C., additional, Wegner, P. J., additional, Whitman, P. K., additional, Hamza, A., additional, Dzenitis, E. G., additional, Wallace, R. J., additional, Bhandarkar, S. D., additional, Parham, T. G., additional, Dylla-Spears, R., additional, Mapoles, E. R., additional, Kozioziemski, B. J., additional, Sater, J. D., additional, Walters, C. F., additional, Haid, B. J., additional, Fair, J., additional, Nikroo, A., additional, Giraldez, E., additional, Moreno, K., additional, Vanwonterghem, B., additional, Kauffman, R. L., additional, Batha, S., additional, Larson, D. W., additional, Fortner, R. J., additional, Schneider, D. H., additional, Lindl, J. D., additional, Patterson, R. W., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2012
Full Text
View/download PDF

17. Cryogenic thermonuclear fuel implosions on the National Ignition Facility

Author

Glenzer, S. H., primary, Callahan, D. A., additional, MacKinnon, A. J., additional, Kline, J. L., additional, Grim, G., additional, Alger, E. T., additional, Berger, R. L., additional, Bernstein, L. A., additional, Betti, R., additional, Bleuel, D. L., additional, Boehly, T. R., additional, Bradley, D. K., additional, Burkhart, S. C., additional, Burr, R., additional, Caggiano, J. A., additional, Castro, C., additional, Casey, D. T., additional, Choate, C., additional, Clark, D. S., additional, Celliers, P., additional, Cerjan, C. J., additional, Collins, G. W., additional, Dewald, E. L., additional, DiNicola, P., additional, DiNicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Döppner, T., additional, Dylla-Spears, R., additional, Dzenitis, E., additional, Eckart, M., additional, Erbert, G., additional, Farley, D., additional, Fair, J., additional, Fittinghoff, D., additional, Frank, M., additional, Frenje, L. J. A., additional, Friedrich, S., additional, Gatu Johnson, M., additional, Gibson, C., additional, Giraldez, E., additional, Glebov, V., additional, Glenn, S., additional, Guler, N., additional, Haan, S. W., additional, Haid, B. J., additional, Hammel, B. A., additional, Hamza, A. V., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M., additional, Hermann, H. W., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Holder, J. P., additional, Holunda, D. M., additional, Horner, J. B., additional, Hsing, W. W., additional, Huang, H., additional, Izumi, N., additional, Jackson, M., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kauffman, R., additional, Kilkenny, J. D., additional, Kirkwood, R. K., additional, Klingmann, J., additional, Kohut, T., additional, Knauer, J. P., additional, Koch, J. A., additional, Kozioziemki, B., additional, Kyrala, G. A., additional, Kritcher, A. L., additional, Kroll, J., additional, La Fortune, K., additional, Lagin, L., additional, Landen, O. L., additional, Larson, D. W., additional, LaTray, D., additional, Leeper, R. J., additional, Le Pape, S., additional, Lindl, J. D., additional, Lowe-Webb, R., additional, Ma, T., additional, McNaney, J., additional, MacPhee, A. G., additional, Malsbury, T. N., additional, Mapoles, E., additional, Marshall, C. D., additional, Meezan, N. B., additional, Merrill, F., additional, Michel, P., additional, Moody, J. D., additional, Moore, A. S., additional, Moran, M., additional, Moreno, K. A., additional, Munro, D. H., additional, Nathan, B. R., additional, Nikroo, A., additional, Olson, R. E., additional, Orth, C. D., additional, Pak, A. E., additional, Patel, P. K., additional, Parham, T., additional, Petrasso, R., additional, Ralph, J. E., additional, Rinderknecht, H., additional, Regan, S. P., additional, Robey, H. F., additional, Ross, J. S., additional, Rosen, M. D., additional, Sacks, R., additional, Salmonson, J. D., additional, Saunders, R., additional, Sater, J., additional, Sangster, C., additional, Schneider, M. B., additional, Séguin, F. H., additional, Shaw, M. J., additional, Spears, B. K., additional, Springer, P. T., additional, Stoeffl, W., additional, Suter, L. J., additional, Thomas, C. A., additional, Tommasini, R., additional, Town, R. P. J., additional, Walters, C., additional, Weaver, S., additional, Weber, S. V., additional, Wegner, P. J., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilde, C. H., additional, Wilson, D. C., additional, Van Wonterghem, B., additional, MacGowan, B. J., additional, Atherton, L. J., additional, Edwards, M. J., additional, and Moses, E. I., additional

Published
2012
Full Text
View/download PDF

18. Publisher’s Note: Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums [Phys. Rev. Lett.106, 085004 (2011)]

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, DuPuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T., additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzales, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D. A., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M.-Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T. E., additional, Milovich, J. L., additional, Miramontes-Ortiz, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendleton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strauser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D. J., additional, Truong, J. H., additional, Vaher, J. L., additional, Valadez, M. C., additional, Van Arsdall, P. J., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E. F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
Full Text
View/download PDF

19. Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bezerides, L., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, Dupuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T, additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Forsman, A., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzalez, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M. -Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T., additional, Milovich, J. L., additional, Miramontes, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendlton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strausser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D., additional, Truong, J., additional, Vaher, J., additional, Valadez, M., additional, Van Arsdall, P., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zaleski, T., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
Full Text
View/download PDF

22. The national ignition facility: Status and performance of the world’s largest laser system for the high energy density and inertial confinement fusion

Author

Haynam, C.A., primary, Wegner, P. J., additional, Heestand, G. M., additional, Moses, E., additional, Sacks, R. A., additional, Bowers, M. W., additional, Dixit, S. N., additional, Erbert, G. V., additional, Henesian, M. A., additional, Hermann, M. R., additional, Jancaitis, K. S., additional, Knittel, K., additional, Kohut, T., additional, Manes, K. R., additional, Marshall, C. D., additional, Mehta, N. C., additional, Menapace, J., additional, Murray, J. R., additional, Nostrand, M. C., additional, Orth, C. D., additional, Patterson, R., additional, Saunders, R., additional, Shaw, M. J., additional, Spaeth, M., additional, Sutton, S. B., additional, Williams, W. H., additional, Widmayer, C. C., additional, White, R. K., additional, Yang, S. T., additional, and Van Wonterghem, B. M., additional

Published
2008
Full Text
View/download PDF

23. The National Ignition Facility 2007 laser performance status

Author

Haynam, C A, primary, Sacks, R A, additional, Wegner, P J, additional, Bowers, M W, additional, Dixit, S N, additional, Erbert, G V, additional, Heestand, G M, additional, Henesian, M A, additional, Hermann, M R, additional, Jancaitis, K S, additional, Manes, K R, additional, Marshall, C D, additional, Mehta, N C, additional, Menapace, J, additional, Nostrand, M C, additional, Orth, C D, additional, Shaw, M J, additional, Sutton, S B, additional, Williams, W H, additional, Widmayer, C C, additional, White, R K, additional, Yang, S T, additional, and Wonterghem, B M Van, additional

Published
2008
Full Text
View/download PDF

24. National Ignition Facility laser performance status

Author

Haynam, C. A., primary, Wegner, P. J., additional, Auerbach, J. M., additional, Bowers, M. W., additional, Dixit, S. N., additional, Erbert, G. V., additional, Heestand, G. M., additional, Henesian, M. A., additional, Hermann, M. R., additional, Jancaitis, K. S., additional, Manes, K. R., additional, Marshall, C. D., additional, Mehta, N. C., additional, Menapace, J., additional, Moses, E., additional, Murray, J. R., additional, Nostrand, M. C., additional, Orth, C. D., additional, Patterson, R., additional, Sacks, R. A., additional, Shaw, M. J., additional, Spaeth, M., additional, Sutton, S. B., additional, Williams, W. H., additional, Widmayer, C. C., additional, White, R. K., additional, Yang, S. T., additional, and Van Wonterghem, B. M., additional

Published
2007
Full Text
View/download PDF

25. The first target experiments on the National Ignition Facility

Author

Landen, O. L., primary, Glenzer, S. H., additional, Froula, D. H., additional, Dewald, E. L., additional, Suter, L. J., additional, Schneider, M. B., additional, Hinkel, D. E., additional, Fernandez, J. C., additional, Kline, J. L., additional, Goldman, S. R., additional, Braun, D. G., additional, Celliers, P. M., additional, Moon, S. J., additional, Robey, H. S., additional, Lanier, N. E., additional, Glendinning, S. G., additional, Blue, B. E., additional, Wilde, B. H., additional, Jones, O. S., additional, Schein, J., additional, Divol, L., additional, Kalantar, D. H., additional, Campbell, K. M., additional, Holder, J. P., additional, McDonald, J. W., additional, Niemann, C., additional, Mackinnon, A. J., additional, Collins, G. W., additional, Bradley, D. K., additional, Eggert, J. H., additional, Hicks, D. G., additional, Gregori, G., additional, Kirkwood, R. K., additional, Young, B. K., additional, Foster, J. M., additional, Hansen, J. F., additional, Perry, T. S., additional, Munro, D. H., additional, Baldis, H. A., additional, Grim, G. P., additional, Heeter, R. F., additional, Hegelich, M. B., additional, Montgomery, D. S., additional, Rochau, G. A., additional, Olson, R. E., additional, Turner, R. E., additional, Workman, J. B., additional, Berger, R. L., additional, Cohen, B. I., additional, Kruer, W. L., additional, Langdon, A. B., additional, Langer, S. H., additional, Meezan, N. B., additional, Rose, H. A., additional, Still, C. H., additional, Williams, E. A., additional, Dodd, E. S., additional, Edwards, M. J., additional, Monteil, M.-C., additional, Stevenson, R. M., additional, Thomas, B. R., additional, Coker, R. F., additional, Magelssen, G. R., additional, Rosen, P. A., additional, Stry, P. E., additional, Woods, D., additional, Weber, S. V., additional, Young, P. E., additional, Alvarez, S., additional, Armstrong, G., additional, Bahr, R., additional, Bourgade, J.-L., additional, Bower, D., additional, Celeste, J., additional, Chrisp, M., additional, Compton, S., additional, Cox, J., additional, Constantin, C., additional, Costa, R., additional, Duncan, J., additional, Ellis, A., additional, Emig, J., additional, Gautier, C., additional, Greenwood, A., additional, Griffith, R., additional, Holdner, F., additional, Holtmeier, G., additional, Hargrove, D., additional, James, T., additional, Kamperschroer, J., additional, Kimbrough, J., additional, Landon, M., additional, Lee, F. D., additional, Malone, R., additional, May, M., additional, Montelongo, S., additional, Moody, J., additional, Ng, E., additional, Nikitin, A., additional, Pellinen, D., additional, Piston, K., additional, Poole, M., additional, Rekow, V., additional, Rhodes, M., additional, Shepherd, R., additional, Shiromizu, S., additional, Voloshin, D., additional, Warrick, A., additional, Watts, P., additional, Weber, F., additional, Young, P., additional, Arnold, P., additional, Atherton, L., additional, Bardsley, G., additional, Bonanno, R., additional, Borger, T., additional, Bowers, M., additional, Bryant, R., additional, Buckman, S., additional, Burkhart, S., additional, Cooper, F., additional, Dixit, S. N., additional, Erbert, G., additional, Eder, D. C., additional, Ehrlich, R. E., additional, Felker, B., additional, Fornes, J., additional, Frieders, G., additional, Gardner, S., additional, Gates, C., additional, Gonzalez, M., additional, Grace, S., additional, Hall, T., additional, Haynam, C. A., additional, Heestand, G., additional, Henesian, M. A., additional, Hermann, M., additional, Hermes, G., additional, Huber, S., additional, Jancaitis, K., additional, Johnson, S., additional, Kauffman, B., additional, Kelleher, T., additional, Kohut, T., additional, Koniges, A. E., additional, Labiak, T., additional, Latray, D., additional, Lee, A., additional, Lund, D., additional, Mahavandi, S., additional, Manes, K. R., additional, Marshall, C., additional, McBride, J., additional, McCarville, T., additional, McGrew, L., additional, Menapace, J., additional, Mertens, E., additional, Murray, J., additional, Neumann, J., additional, Newton, M., additional, Opsahl, P., additional, Padilla, E., additional, Parham, T., additional, Parrish, G., additional, Petty, C., additional, Polk, M., additional, Powell, C., additional, Reinbachs, I., additional, Rinnert, R., additional, Riordan, B., additional, Ross, G., additional, Robert, V., additional, Tobin, M., additional, Sailors, S., additional, Saunders, R., additional, Schmitt, M., additional, Shaw, M., additional, Singh, M., additional, Spaeth, M., additional, Stephens, A., additional, Tietbohl, G., additional, Tuck, J., additional, Van Wonterghem, B. M., additional, Vidal, R., additional, Wegner, P. J., additional, Whitman, P., additional, Williams, K., additional, Winward, K., additional, Work, K., additional, Wallace, R., additional, Nobile, A., additional, Bono, M., additional, Day, B., additional, Elliott, J., additional, Hatch, D., additional, Louis, H., additional, Manzenares, R., additional, O'Brien, D., additional, Papin, P., additional, Pierce, T., additional, Rivera, G., additional, Ruppe, J., additional, Sandoval, D., additional, Schmidt, D., additional, Valdez, L., additional, Zapata, K., additional, MacGowan, B. J., additional, Eckart, M. J., additional, Hsing, W. W., additional, Springer, P. T., additional, Hammel, B. A., additional, Moses, E. I., additional, and Miller, G. H., additional

Published
2006
Full Text
View/download PDF

26. The national ignition facility performance status

Author

Haynam, C., Auerbach, J., Bowers, M., Di-Nicola, J.-M., Dixit, S., Erbert, G., Heestand, G., Henesian, M., Jancaitis, K., Manes, K., Marshall, C., Mehta, N., Nostrand, M., Orth, C., Sacks, R., Shaw, M., Sutton, S., Wegner, P., Williams, W., Widmayer, C., White, R., Yang, S., Van Wonterghem, B., Haynam, C., Auerbach, J., Bowers, M., Di-Nicola, J.-M., Dixit, S., Erbert, G., Heestand, G., Henesian, M., Jancaitis, K., Manes, K., Marshall, C., Mehta, N., Nostrand, M., Orth, C., Sacks, R., Shaw, M., Sutton, S., Wegner, P., Williams, W., Widmayer, C., White, R., Yang, S., and Van Wonterghem, B.

Abstract

The National Ignition Facility (NIF) laser has been designed to support high energy density science (HEDS), including the demonstration of fusion ignition through Inertial Confinement. NIF operated a single “quad” of 4 beams from December 2002 through October 2004 in order to gain laser operations experience, support target experiments, and demonstrate laser performance consistent with NIF's design requirement. During this two-year period, over 400 Main Laser shots were delivered at 1ωto calorimeters for diagnostic calibration purposes, at 3ωto the Target Chamber, and at 1ω, 2ω, and 3ωto the Precision Diagnostics System (PDS). The PDS includes its own independent single beam transport system, NIF design frequency conversion hardware and optics, and laser sampling optics that deliver light to a broad range of laser diagnostics. Highlights of NIF laser performance will be discussed including the results of high energy 2ωand 3ωexperiments, the use of multiple focal spot beam conditioning techniques, the reproducibility of laser performance on multiple shots, the generation on a single beam of a 3ωtemporally shaped ignition pulse at full energy and power, and recent results on full bundle (8 beamline) performance. NIF's first quad laser performance meets or exceeds NIF's design requirements.

Published
2006
Full Text
View/download PDF

27. The first experiments on the national ignition facility

Author

Landen, O. L., Glenzer, S., Froula, D., Dewald, E., Suter, L. J., Schneider, M., Hinkel, D., Fernandez, J., Kline, J., Goldman, S., Braun, D., Celliers, P., Moon, S., Robey, H., Lanier, N., Glendinning, G., Blue, B., Wilde, B., Jones, O., Schein, J., Divol, L., Kalantar, D., Campbell, K., Holder, J., McDonald, J., Niemann, C., Mackinnon, A., Collins, R., Bradley, D., Eggert, J., Hicks, D., Gregori, G., Kirkwood, R., Niemann, C., Young, B., Foster, J., Hansen, F., Perry, T., Munro, D., Baldis, H., Grim, G., Heeter, R., Hegelich, B., Montgomery, D., Rochau, G., Olson, R., Turner, R., Workman, J., Berger, R., Cohen, B., Kruer, W., Langdon, B., Langer, S., Meezan, N., Rose, H., Still, B., Williams, E., Dodd, E., Edwards, J., Monteil, M.-C., Stevenson, M., Thomas, B., Coker, R., Magelssen, G., Rosen, P., Stry, P., Woods, D., Weber, S., Alvarez, S., Armstrong, G., Bahr, R., Bourgade, J.-L., Bower, D., Celeste, J., Chrisp, M., Compton, S., Cox, J., Constantin, C., Costa, R., Duncan, J., Ellis, A., Emig, J., Gautier, C., Greenwood, A., Griffith, R., Holdner, F., Holtmeier, G., Hargrove, D., James, T., Kamperschroer, J., Kimbrough, J., Landon, M., Lee, D., Malone, R., May, M., Montelongo, S., Moody, J., Ng, E., Nikitin, A., Pellinen, D., Piston, K., Poole, M., Rekow, V., Rhodes, M., Shepherd, R., Shiromizu, S., Voloshin, D., Warrick, A., Watts, P., Weber, F., Young, P., Arnold, P., Atherton, L., Bardsley, G., Bonanno, R., Borger, T., Bowers, M., Bryant, R., Buckman, S., Burkhart, S., Cooper, F., Dixit, S., Erbert, G., Eder, D., Ehrlich, B., Felker, B., Fornes, J., Frieders, G., Gardner, S., Gates, C., Gonzalez, M., Grace, S., Hall, T., Haynam, C., Heestand, G., Henesian, M., Hermann, M., Hermes, G., Huber, S., Jancaitis, K., Johnson, S., Kauffman, B., Kelleher, T., Kohut, T., Koniges, A. E., Labiak, T., Latray, D., Lee, A., Lund, D., Mahavandi, S., Manes, K. R., Marshall, C., McBride, J., McCarville, T., McGrew, L., Menapace, J., Mertens, E., Munro, D., Murray, J., Neumann, J., Newton, M., Opsahl, P., Padilla, E., Parham, T., Parrish, G., Petty, C., Polk, M., Powell, C., Reinbachs, I., Rinnert, R., Riordan, B., Ross, G., Robert, V., Tobin, M., Sailors, S., Saunders, R., Schmitt, M., Shaw, M., Singh, M., Spaeth, M., Stephens, A., Tietbohl, G., Tuck, J., Van Wonterghem, B., Vidal, R., Wegner, P., Whitman, P., Williams, K., Winward, K., Work, K., Wallace, R., Nobile, A., Bono, M., Day, B., Elliott, J., Hatch, D., Louis, H., Manzenares, R., O'Brien, D., Papin, P., Pierce, T., Rivera, G., Ruppe, J., Sandoval, D., Schmidt, D., Valdez, L., Zapata, K., MacGowan, B., Eckart, M., Hsing, W., Springer, P., Hammel, B., Moses, E., Miller, G., Landen, O. L., Glenzer, S., Froula, D., Dewald, E., Suter, L. J., Schneider, M., Hinkel, D., Fernandez, J., Kline, J., Goldman, S., Braun, D., Celliers, P., Moon, S., Robey, H., Lanier, N., Glendinning, G., Blue, B., Wilde, B., Jones, O., Schein, J., Divol, L., Kalantar, D., Campbell, K., Holder, J., McDonald, J., Niemann, C., Mackinnon, A., Collins, R., Bradley, D., Eggert, J., Hicks, D., Gregori, G., Kirkwood, R., Niemann, C., Young, B., Foster, J., Hansen, F., Perry, T., Munro, D., Baldis, H., Grim, G., Heeter, R., Hegelich, B., Montgomery, D., Rochau, G., Olson, R., Turner, R., Workman, J., Berger, R., Cohen, B., Kruer, W., Langdon, B., Langer, S., Meezan, N., Rose, H., Still, B., Williams, E., Dodd, E., Edwards, J., Monteil, M.-C., Stevenson, M., Thomas, B., Coker, R., Magelssen, G., Rosen, P., Stry, P., Woods, D., Weber, S., Alvarez, S., Armstrong, G., Bahr, R., Bourgade, J.-L., Bower, D., Celeste, J., Chrisp, M., Compton, S., Cox, J., Constantin, C., Costa, R., Duncan, J., Ellis, A., Emig, J., Gautier, C., Greenwood, A., Griffith, R., Holdner, F., Holtmeier, G., Hargrove, D., James, T., Kamperschroer, J., Kimbrough, J., Landon, M., Lee, D., Malone, R., May, M., Montelongo, S., Moody, J., Ng, E., Nikitin, A., Pellinen, D., Piston, K., Poole, M., Rekow, V., Rhodes, M., Shepherd, R., Shiromizu, S., Voloshin, D., Warrick, A., Watts, P., Weber, F., Young, P., Arnold, P., Atherton, L., Bardsley, G., Bonanno, R., Borger, T., Bowers, M., Bryant, R., Buckman, S., Burkhart, S., Cooper, F., Dixit, S., Erbert, G., Eder, D., Ehrlich, B., Felker, B., Fornes, J., Frieders, G., Gardner, S., Gates, C., Gonzalez, M., Grace, S., Hall, T., Haynam, C., Heestand, G., Henesian, M., Hermann, M., Hermes, G., Huber, S., Jancaitis, K., Johnson, S., Kauffman, B., Kelleher, T., Kohut, T., Koniges, A. E., Labiak, T., Latray, D., Lee, A., Lund, D., Mahavandi, S., Manes, K. R., Marshall, C., McBride, J., McCarville, T., McGrew, L., Menapace, J., Mertens, E., Munro, D., Murray, J., Neumann, J., Newton, M., Opsahl, P., Padilla, E., Parham, T., Parrish, G., Petty, C., Polk, M., Powell, C., Reinbachs, I., Rinnert, R., Riordan, B., Ross, G., Robert, V., Tobin, M., Sailors, S., Saunders, R., Schmitt, M., Shaw, M., Singh, M., Spaeth, M., Stephens, A., Tietbohl, G., Tuck, J., Van Wonterghem, B., Vidal, R., Wegner, P., Whitman, P., Williams, K., Winward, K., Work, K., Wallace, R., Nobile, A., Bono, M., Day, B., Elliott, J., Hatch, D., Louis, H., Manzenares, R., O'Brien, D., Papin, P., Pierce, T., Rivera, G., Ruppe, J., Sandoval, D., Schmidt, D., Valdez, L., Zapata, K., MacGowan, B., Eckart, M., Hsing, W., Springer, P., Hammel, B., Moses, E., and Miller, G.

Abstract

A first set of shock propagation, laser-plasma interaction, hohlraum energetics and hydrodynamic experiments have been performed using the first 4 beams of the National Ignition Facility (NIF), in support of indirect drive Inertial Confinement Fusion (ICF) and High Energy Density Physics.

Published
2006
Full Text
View/download PDF

28. Progress in long scale length laser-plasma interactions

Author

Glenzer, S. H., Arnold, P., Bardsley, G., Berger, R. L., Bonanno, G., Borger, T., Bower, D. E., Bowers, M., Bryant, R., Buckman, S., Burkhart, S. C., Campbell, K., Chrisp, M. P., Cohen, B. I., Constantin, C., Cooper, F., Cox, J., Dewald, E., Divol, L., Dixit, S., Duncan, J., Eder, D., Edwards, J., Erbert, G., Felker, B., Fornes, J., Frieders, G., Dustin Froula, Gardner, S. D., Gates, C., Gonzalez, M., Grace, S., Gregori, G., Greenwood, A., Griffith, R., Hall, T., Hammel, B. A., Haynam, C., Heestand, G., Henesian, M., Hermes, G., Hinkel, D., Holder, J., Holdner, F., Holtmeier, G., Hsing, W., Huber, S., James, T., Johnson, S., Jones, O. S., Kalantar, D., Kamperschroer, J. H., Kauffman, R., Kelleher, T., Knight, J., Kirkwood, R. K., Kruer, W. L., Labiak, W., Landen, O. L., Langdon, A. B., Langer, S., Latray, D., Lee, A., Lee, F. D., Lund, D., Macgowan, B., Marshall, S., Mcbride, J., Mccarville, T., Mcgrew, L., Mackinnon, A. J., Mahavandi, S., Manes, K., Marshall, C., Menapace, J., Mertens, E., Meezan, N., Miller, G., Montelongo, S., Moody, J. D., Moses, E., Munro, D., Murray, J., Neumann, J., Newton, M., Ng, E., Niemann, C., Nikitin, A., Opsahl, P., Padilla, E., Parham, T., Parrish, G., Petty, C., Polk, M., Powell, C., Reinbachs, I., Rekow, V., Rinnert, R., and Riordan, B.

Subjects
Physics::Plasma Physics
Abstract

The first experiments on the National Ignition Facility (NIF) have employed the first four beams to measure propagation and laser backscattering losses in large ignition-size plasmas. Gas-filled targets between 2 mm and 7 mm length have been heated from one side by overlapping the focal spots of the four beams from one quad operated at 351 nm (3ω) with a total intensity of 2×1015W cm-2. The targets were filled with 1 atm of CO2 producing of up to 7 mm long homogeneously heated plasmas with densities of ne = 6 × 1020cm-3 and temperatures of Te = 2 keV. The high energy in a NIF quad of beams of 16kJ, illuminating the target from one direction, creates unique conditions for the study of laser plasma interactions at scale lengths not previously accessible. The propagation through the large-scale plasma was measured with a gated x-ray imager that was filtered for 3.5 keVx rays. These data indicate that the beams interact with the full length of this ignition-scale plasma during the last ∼1 ns of the experiment. During that time, the full aperture measurements of the stimulated Brillouin scattering and stimulated Raman scattering show scattering into the four focusing lenses of 3% for the smallest length (∼2 mm), increasing to 10-12% for ∼7 mm. These results demonstrate the NIF experimental capabilities and further provide a benchmark for three-dimensional modeling of the laser-plasma interactions at ignition-size scale lengths.

31. P5:01 A FIRST IN HUMAN, DOSE ESCALATION TRIAL OF MSC2363318A – A DUAL P70S6K/AKT INHIBITOR, FOR PATIENTS WITH ADVANCED MALIGNANCIES

Author

Tsimberidou, A. M., Verschraegen, C., Heestand, G., Kaleta, R., Scheuenpflug, J., Huck, B., Weise, A., and Kurzrock, R.

Abstract

Background: The PI3K/Akt/PTEN pathway regulates cellular functions including growth, proliferation and metabolism. Aberrant pathway signaling (PTEN loss of function, PIK3CA mutation, Akt amplification, etc.) occurs in >50% of all tumors, and pathway inhibition is used for the treatment of solid tumors and hematopoietic malignancies. Whereas mTOR inhibition activates a negative feedback loop, leading to Akt activation, dual p70S6K/Akt inhibition may improve pathway inhibition whilst blocking negative consequences of Akt activation via the feedback loop. MSC2363318A is a brain penetrant, kinase-selective, ATP competitive inhibitor of p70S6K, Akt1, and Akt3. MSC2363318A exhibits potent anti-proliferative activity in vitro, particularly in tumor cells with PI3K pathway genomic alterations, and antitumor activity in vivo, in xenograft models of breast, pancreatic and ovarian cancers, and glioblastoma. Trial design and current results: This is a standard 3 + 3 dose escalation study of single-agent MSC2363318A given orally daily in 21-day cycles. Eligible patients must have confirmed diagnosis of advanced malignancy with high prevalence of PI3K/Akt/ PTEN pathway genomic or molecular alterations. The primary objective is to determine maximum tolerated dose, identify dose limiting toxicities (DLTs) and establish a recommended phase 2 dose. Secondary objectives include characterization of pharmacodynamic and pharmacokinetic (PK) properties, and evaluation of predictive biomarkers for safety and efficacy. Observed antitumor activity in the dose escalation part will guide the selection of tumor specific cohorts for the expansion phase. Fifteen patients were treated at 5 dose levels ranging from 15–110 mg/day. To date, 1 DLT (G3 lipase increase) has been observed in 1 of 6 patients treated at the 60mg dose. Nine patients have discontinued treatment due to disease progression (n = 7), death (n = 1), or toxicity (n = 1). Best clinical response to date is stable disease (SD) lasting 6–36+ wks (n = 6). Longest SDs are 36+ wks (adenocystic carcinoma of the salivary gland) and 27 wks (recurrent small cell lung cancer). Updated safety, efficacy and biomarker data, individual examples of on target effects in tumor biopsies from the escalation phase, and preliminary PK data will be presented. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

34. COMPANION-002 A clinical trial of investigational drug CTX-009 plus paclitaxel vs paclitaxel in second line advanced BTC.

Author

Azad N, Hu Z, Sahin I, Iyer R, Aranha O, Hochster H, Pathak P, Paulson AS, Kalyan A, Liao CY, Tran N, Kelley RK, Heestand G, Cosgrove D, El-Khoueiry A, Borad M, Gabrail NY, Majeed U, Du L, Kamath S, Shumway N, Shroff R, Goyal L, Rosales M, and Javle M

Abstract

Treatment options for patients with biliary tract cancer are limited, and the prognosis is poor. CTX-009, a novel bispecific antibody targeting both DLL4 and VEGF-A, has demonstrated antitumor activity in patients with advanced cancers as both a monotherapy and in combination with chemotherapy. In a phase II study of patients with advanced biliary tract cancer who had received one or two prior therapies, CTX-009 with paclitaxel demonstrated a 37.5% overall response rate (ORR). Described here is the design of and rationale for COMPANION-002, a randomized phase II/III study, which will evaluate the safety and efficacy of CTX-009 in combination with paclitaxel versus paclitaxel alone as second-line treatment for patients with advanced biliary tract cancer. The primary end point is ORR, and crossover is allowed. Clinical Trial Registration: NCT05506943 (ClinicalTrials.gov).

Published
2024
Full Text
View/download PDF

35. Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Author

Abu-Shawareb H, Acree R, Adams P, Adams J, Addis B, Aden R, Adrian P, Afeyan BB, Aggleton M, Aghaian L, Aguirre A, Aikens D, Akre J, Albert F, Albrecht M, Albright BJ, Albritton J, Alcala J, Alday C, Alessi DA, Alexander N, Alfonso J, Alfonso N, Alger E, Ali SJ, Ali ZA, Allen A, Alley WE, Amala P, Amendt PA, Amick P, Ammula S, Amorin C, Ampleford DJ, Anderson RW, Anklam T, Antipa N, Appelbe B, Aracne-Ruddle C, Araya E, Archuleta TN, Arend M, Arnold P, Arnold T, Arsenlis A, Asay J, Atherton LJ, Atkinson D, Atkinson R, Auerbach JM, Austin B, Auyang L, Awwal AAS, Aybar N, Ayers J, Ayers S, Ayers T, Azevedo S, Bachmann B, Back CA, Bae J, Bailey DS, Bailey J, Baisden T, Baker KL, Baldis H, Barber D, Barberis M, Barker D, Barnes A, Barnes CW, Barrios MA, Barty C, Bass I, Batha SH, Baxamusa SH, Bazan G, Beagle JK, Beale R, Beck BR, Beck JB, Bedzyk M, Beeler RG, Beeler RG, Behrendt W, Belk L, Bell P, Belyaev M, Benage JF, Bennett G, Benedetti LR, Benedict LX, Berger RL, Bernat T, Bernstein LA, Berry B, Bertolini L, Besenbruch G, Betcher J, Bettenhausen R, Betti R, Bezzerides B, Bhandarkar SD, Bickel R, Biener J, Biesiada T, Bigelow K, Bigelow-Granillo J, Bigman V, Bionta RM, Birge NW, Bitter M, Black AC, Bleile R, Bleuel DL, Bliss E, Bliss E, Blue B, Boehly T, Boehm K, Boley CD, Bonanno R, Bond EJ, Bond T, Bonino MJ, Borden M, Bourgade JL, Bousquet J, Bowers J, Bowers M, Boyd R, Boyle D, Bozek A, Bradley DK, Bradley KS, Bradley PA, Bradley L, Brannon L, Brantley PS, Braun D, Braun T, Brienza-Larsen K, Briggs R, Briggs TM, Britten J, Brooks ED, Browning D, Bruhn MW, Brunner TA, Bruns H, Brunton G, Bryant B, Buczek T, Bude J, Buitano L, Burkhart S, Burmark J, Burnham A, Burr R, Busby LE, Butlin B, Cabeltis R, Cable M, Cabot WH, Cagadas B, Caggiano J, Cahayag R, Caldwell SE, Calkins S, Callahan DA, Calleja-Aguirre J, Camara L, Camp D, Campbell EM, Campbell JH, Carey B, Carey R, Carlisle K, Carlson L, Carman L, Carmichael J, Carpenter A, Carr C, Carrera JA, Casavant D, Casey A, Casey DT, Castillo A, Castillo E, Castor JI, Castro C, Caughey W, Cavitt R, Celeste J, Celliers PM, Cerjan C, Chandler G, Chang B, Chang C, Chang J, Chang L, Chapman R, Chapman TD, Chase L, Chen H, Chen H, Chen K, Chen LY, Cheng B, Chittenden J, Choate C, Chou J, Chrien RE, Chrisp M, Christensen K, Christensen M, Christiansen NS, Christopherson AR, Chung M, Church JA, Clark A, Clark DS, Clark K, Clark R, Claus L, Cline B, Cline JA, Cobble JA, Cochrane K, Cohen B, Cohen S, Collette MR, Collins GW, Collins LA, Collins TJB, Conder A, Conrad B, Conyers M, Cook AW, Cook D, Cook R, Cooley JC, Cooper G, Cope T, Copeland SR, Coppari F, Cortez J, Cox J, Crandall DH, Crane J, Craxton RS, Cray M, Crilly A, Crippen JW, Cross D, Cuneo M, Cuotts G, Czajka CE, Czechowicz D, Daly T, Danforth P, Danly C, Darbee R, Darlington B, Datte P, Dauffy L, Davalos G, Davidovits S, Davis P, Davis J, Dawson S, Day RD, Day TH, Dayton M, Deck C, Decker C, Deeney C, DeFriend KA, Deis G, Delamater ND, Delettrez JA, Demaret R, Demos S, Dempsey SM, Desjardin R, Desjardins T, Desjarlais MP, Dewald EL, DeYoreo J, Diaz S, Dimonte G, Dittrich TR, Divol L, Dixit SN, Dixon J, Do A, Dodd ES, Dolan D, Donovan A, Donovan M, Döppner T, Dorrer C, Dorsano N, Douglas MR, Dow D, Downie J, Downing E, Dozieres M, Draggoo V, Drake D, Drake RP, Drake T, Dreifuerst G, Drury O, DuBois DF, DuBois PF, Dunham G, Durocher M, Dylla-Spears R, Dymoke-Bradshaw AKL, Dzenitis B, Ebbers C, Eckart M, Eddinger S, Eder D, Edgell D, Edwards MJ, Efthimion P, Eggert JH, Ehrlich B, Ehrmann P, Elhadj S, Ellerbee C, Elliott NS, Ellison CL, Elsner F, Emerich M, Engelhorn K, England T, English E, Epperson P, Epstein R, Erbert G, Erickson MA, Erskine DJ, Erlandson A, Espinosa RJ, Estes C, Estabrook KG, Evans S, Fabyan A, Fair J, Fallejo R, Farmer N, Farmer WA, Farrell M, Fatherley VE, Fedorov M, Feigenbaum E, Fehrenbach T, Feit M, Felker B, Ferguson W, Fernandez JC, Fernandez-Panella A, Fess S, Field JE, Filip CV, Fincke JR, Finn T, Finnegan SM, Finucane RG, Fischer M, Fisher A, Fisher J, Fishler B, Fittinghoff D, Fitzsimmons P, Flegel M, Flippo KA, Florio J, Folta J, Folta P, Foreman LR, Forrest C, Forsman A, Fooks J, Foord M, Fortner R, Fournier K, Fratanduono DE, Frazier N, Frazier T, Frederick C, Freeman MS, Frenje J, Frey D, Frieders G, Friedrich S, Froula DH, Fry J, Fuller T, Gaffney J, Gales S, Le Galloudec B, Le Galloudec KK, Gambhir A, Gao L, Garbett WJ, Garcia A, Gates C, Gaut E, Gauthier P, Gavin Z, Gaylord J, Geddes CGR, Geissel M, Génin F, Georgeson J, Geppert-Kleinrath H, Geppert-Kleinrath V, Gharibyan N, Gibson J, Gibson C, Giraldez E, Glebov V, Glendinning SG, Glenn S, Glenzer SH, Goade S, Gobby PL, Goldman SR, Golick B, Gomez M, Goncharov V, Goodin D, Grabowski P, Grafil E, Graham P, Grandy J, Grasz E, Graziani FR, Greenman G, Greenough JA, Greenwood A, Gregori G, Green T, Griego JR, Grim GP, Grondalski J, Gross S, Guckian J, Guler N, Gunney B, Guss G, Haan S, Hackbarth J, Hackel L, Hackel R, Haefner C, Hagmann C, Hahn KD, Hahn S, Haid BJ, Haines BM, Hall BM, Hall C, Hall GN, Hamamoto M, Hamel S, Hamilton CE, Hammel BA, Hammer JH, Hampton G, Hamza A, Handler A, Hansen S, Hanson D, Haque R, Harding D, Harding E, Hares JD, Harris DB, Harte JA, Hartouni EP, Hatarik R, Hatchett S, Hauer AA, Havre M, Hawley R, Hayes J, Hayes J, Hayes S, Hayes-Sterbenz A, Haynam CA, Haynes DA, Headley D, Heal A, Heebner JE, Heerey S, Heestand GM, Heeter R, Hein N, Heinbockel C, Hendricks C, Henesian M, Heninger J, Henrikson J, Henry EA, Herbold EB, Hermann MR, Hermes G, Hernandez JE, Hernandez VJ, Herrmann MC, Herrmann HW, Herrera OD, Hewett D, Hibbard R, Hicks DG, Higginson DP, Hill D, Hill K, Hilsabeck T, Hinkel DE, Ho DD, Ho VK, Hoffer JK, Hoffman NM, Hohenberger M, Hohensee M, Hoke W, Holdener D, Holdener F, Holder JP, Holko B, Holunga D, Holzrichter JF, Honig J, Hoover D, Hopkins D, Berzak Hopkins LF, Hoppe M, Hoppe ML, Horner J, Hornung R, Horsfield CJ, Horvath J, Hotaling D, House R, Howell L, Hsing WW, Hu SX, Huang H, Huckins J, Hui H, Humbird KD, Hund J, Hunt J, Hurricane OA, Hutton M, Huynh KH, Inandan L, Iglesias C, Igumenshchev IV, Ivanovich I, Izumi N, Jackson M, Jackson J, Jacobs SD, James G, Jancaitis K, Jarboe J, Jarrott LC, Jasion D, Jaquez J, Jeet J, Jenei AE, Jensen J, Jimenez J, Jimenez R, Jobe D, Johal Z, Johns HM, Johnson D, Johnson MA, Gatu Johnson M, Johnson RJ, Johnson S, Johnson SA, Johnson T, Jones K, Jones O, Jones M, Jorge R, Jorgenson HJ, Julian M, Jun BI, Jungquist R, Kaae J, Kabadi N, Kaczala D, Kalantar D, Kangas K, Karasiev VV, Karasik M, Karpenko V, Kasarky A, Kasper K, Kauffman R, Kaufman MI, Keane C, Keaty L, Kegelmeyer L, Keiter PA, Kellett PA, Kellogg J, Kelly JH, Kemic S, Kemp AJ, Kemp GE, Kerbel GD, Kershaw D, Kerr SM, Kessler TJ, Key MH, Khan SF, Khater H, Kiikka C, Kilkenny J, Kim Y, Kim YJ, Kimko J, Kimmel M, Kindel JM, King J, Kirkwood RK, Klaus L, Klem D, Kline JL, Klingmann J, Kluth G, Knapp P, Knauer J, Knipping J, Knudson M, Kobs D, Koch J, Kohut T, Kong C, Koning JM, Koning P, Konior S, Kornblum H, Kot LB, Kozioziemski B, Kozlowski M, Kozlowski PM, Krammen J, Krasheninnikova NS, Krauland CM, Kraus B, Krauser W, Kress JD, Kritcher AL, Krieger E, Kroll JJ, Kruer WL, Kruse MKG, Kucheyev S, Kumbera M, Kumpan S, Kunimune J, Kur E, Kustowski B, Kwan TJT, Kyrala GA, Laffite S, Lafon M, LaFortune K, Lagin L, Lahmann B, Lairson B, Landen OL, Land T, Lane M, Laney D, Langdon AB, Langenbrunner J, Langer SH, Langro A, Lanier NE, Lanier TE, Larson D, Lasinski BF, Lassle D, LaTray D, Lau G, Lau N, Laumann C, Laurence A, Laurence TA, Lawson J, Le HP, Leach RR, Leal L, Leatherland A, LeChien K, Lechleiter B, Lee A, Lee M, Lee T, Leeper RJ, Lefebvre E, Leidinger JP, LeMire B, Lemke RW, Lemos NC, Le Pape S, Lerche R, Lerner S, Letts S, Levedahl K, Lewis T, Li CK, Li H, Li J, Liao W, Liao ZM, Liedahl D, Liebman J, Lindford G, Lindman EL, Lindl JD, Loey H, London RA, Long F, Loomis EN, Lopez FE, Lopez H, Losbanos E, Loucks S, Lowe-Webb R, Lundgren E, Ludwigsen AP, Luo R, Lusk J, Lyons R, Ma T, Macallop Y, MacDonald MJ, MacGowan BJ, Mack JM, Mackinnon AJ, MacLaren SA, MacPhee AG, Magelssen GR, Magoon J, Malone RM, Malsbury T, Managan R, Mancini R, Manes K, Maney D, Manha D, Mannion OM, Manuel AM, Manuel MJ, Mapoles E, Mara G, Marcotte T, Marin E, Marinak MM, Mariscal DA, Mariscal EF, Marley EV, Marozas JA, Marquez R, Marshall CD, Marshall FJ, Marshall M, Marshall S, Marticorena J, Martinez JI, Martinez D, Maslennikov I, Mason D, Mason RJ, Masse L, Massey W, Masson-Laborde PE, Masters ND, Mathisen D, Mathison E, Matone J, Matthews MJ, Mattoon C, Mattsson TR, Matzen K, Mauche CW, Mauldin M, McAbee T, McBurney M, Mccarville T, McCrory RL, McEvoy AM, McGuffey C, Mcinnis M, McKenty P, McKinley MS, McLeod JB, McPherson A, Mcquillan B, Meamber M, Meaney KD, Meezan NB, Meissner R, Mehlhorn TA, Mehta NC, Menapace J, Merrill FE, Merritt BT, Merritt EC, Meyerhofer DD, Mezyk S, Mich RJ, Michel PA, Milam D, Miller C, Miller D, Miller DS, Miller E, Miller EK, Miller J, Miller M, Miller PE, Miller T, Miller W, Miller-Kamm V, Millot M, Milovich JL, Minner P, Miquel JL, Mitchell S, Molvig K, Montesanti RC, Montgomery DS, Monticelli M, Montoya A, Moody JD, Moore AS, Moore E, Moran M, Moreno JC, Moreno K, Morgan BE, Morrow T, Morton JW, Moses E, Moy K, Muir R, Murillo MS, Murray JE, Murray JR, Munro DH, Murphy TJ, Munteanu FM, Nafziger J, Nagayama T, Nagel SR, Nast R, Negres RA, Nelson A, Nelson D, Nelson J, Nelson S, Nemethy S, Neumayer P, Newman K, Newton M, Nguyen H, Di Nicola JG, Di Nicola P, Niemann C, Nikroo A, Nilson PM, Nobile A, Noorai V, Nora RC, Norton M, Nostrand M, Note V, Novell S, Nowak PF, Nunez A, Nyholm RA, O'Brien M, Oceguera A, Oertel JA, Oesterle AL, Okui J, Olejniczak B, Oliveira J, Olsen P, Olson B, Olson K, Olson RE, Opachich YP, Orsi N, Orth CD, Owen M, Padalino S, Padilla E, Paguio R, Paguio S, Paisner J, Pajoom S, Pak A, Palaniyappan S, Palma K, Pannell T, Papp F, Paras D, Parham T, Park HS, Pasternak A, Patankar S, Patel MV, Patel PK, Patterson R, Patterson S, Paul B, Paul M, Pauli E, Pearce OT, Pearcy J, Pedretti A, Pedrotti B, Peer A, Pelz LJ, Penetrante B, Penner J, Perez A, Perkins LJ, Pernice E, Perry TS, Person S, Petersen D, Petersen T, Peterson DL, Peterson EB, Peterson JE, Peterson JL, Peterson K, Peterson RR, Petrasso RD, Philippe F, Phillion D, Phipps TJ, Piceno E, Pickworth L, Ping Y, Pino J, Piston K, Plummer R, Pollack GD, Pollaine SM, Pollock BB, Ponce D, Ponce J, Pontelandolfo J, Porter JL, Post J, Poujade O, Powell C, Powell H, Power G, Pozulp M, Prantil M, Prasad M, Pratuch S, Price S, Primdahl K, Prisbrey S, Procassini R, Pruyne A, Pudliner B, Qiu SR, Quan K, Quinn M, Quintenz J, Radha PB, Rainer F, Ralph JE, Raman KS, Raman R, Rambo PW, Rana S, Randewich A, Rardin D, Ratledge M, Ravelo N, Ravizza F, Rayce M, Raymond A, Raymond B, Reed B, Reed C, Regan S, Reichelt B, Reis V, Reisdorf S, Rekow V, Remington BA, Rendon A, Requieron W, Rever M, Reynolds H, Reynolds J, Rhodes J, Rhodes M, Richardson MC, Rice B, Rice NG, Rieben R, Rigatti A, Riggs S, Rinderknecht HG, Ring K, Riordan B, Riquier R, Rivers C, Roberts D, Roberts V, Robertson G, Robey HF, Robles J, Rocha P, Rochau G, Rodriguez J, Rodriguez S, Rosen MD, Rosenberg M, Ross G, Ross JS, Ross P, Rouse J, Rovang D, Rubenchik AM, Rubery MS, Ruiz CL, Rushford M, Russ B, Rygg JR, Ryujin BS, Sacks RA, Sacks RF, Saito K, Salmon T, Salmonson JD, Sanchez J, Samuelson S, Sanchez M, Sangster C, Saroyan A, Sater J, Satsangi A, Sauers S, Saunders R, Sauppe JP, Sawicki R, Sayre D, Scanlan M, Schaffers K, Schappert GT, Schiaffino S, Schlossberg DJ, Schmidt DW, Schmit PF, Smidt JM, Schneider DHG, Schneider MB, Schneider R, Schoff M, Schollmeier M, Schroeder CR, Schrauth SE, Scott HA, Scott I, Scott JM, Scott RHH, Scullard CR, Sedillo T, Seguin FH, Seka W, Senecal J, Sepke SM, Seppala L, Sequoia K, Severyn J, Sevier JM, Sewell N, Seznec S, Shah RC, Shamlian J, Shaughnessy D, Shaw M, Shaw R, Shearer C, Shelton R, Shen N, Sherlock MW, Shestakov AI, Shi EL, Shin SJ, Shingleton N, Shmayda W, Shor M, Shoup M, Shuldberg C, Siegel L, Silva FJ, Simakov AN, Sims BT, Sinars D, Singh P, Sio H, Skulina K, Skupsky S, Slutz S, Sluyter M, Smalyuk VA, Smauley D, Smeltser RM, Smith C, Smith I, Smith J, Smith L, Smith R, Smith R, Schölmerich M, Sohn R, Sommer S, Sorce C, Sorem M, Soures JM, Spaeth ML, Spears BK, Speas S, Speck D, Speck R, Spears J, Spinka T, Springer PT, Stadermann M, Stahl B, Stahoviak J, Stanley J, Stanton LG, Steele R, Steele W, Steinman D, Stemke R, Stephens R, Sterbenz S, Sterne P, Stevens D, Stevers J, Still CH, Stoeckl C, Stoeffl W, Stolken JS, Stolz C, Storm E, Stone G, Stoupin S, Stout E, Stowers I, Strauser R, Streckart H, Streit J, Strozzi DJ, Stutz J, Summers L, Suratwala T, Sutcliffe G, Suter LJ, Sutton SB, Svidzinski V, Swadling G, Sweet W, Szoke A, Tabak M, Takagi M, Tambazidis A, Tang V, Taranowski M, Taylor LA, Telford S, Theobald W, Thi M, Thomas A, Thomas CA, Thomas I, Thomas R, Thompson IJ, Thongstisubskul A, Thorsness CB, Tietbohl G, Tipton RE, Tobin M, Tomlin N, Tommasini R, Toreja AJ, Torres J, Town RPJ, Townsend S, Trenholme J, Trivelpiece A, Trosseille C, Truax H, Trummer D, Trummer S, Truong T, Tubbs D, Tubman ER, Tunnell T, Turnbull D, Turner RE, Ulitsky M, Upadhye R, Vaher JL, VanArsdall P, VanBlarcom D, Vandenboomgaerde M, VanQuinlan R, Van Wonterghem BM, Varnum WS, Velikovich AL, Vella A, Verdon CP, Vermillion B, Vernon S, Vesey R, Vickers J, Vignes RM, Visosky M, Vocke J, Volegov PL, Vonhof S, Von Rotz R, Vu HX, Vu M, Wall D, Wall J, Wallace R, Wallin B, Walmer D, Walsh CA, Walters CF, Waltz C, Wan A, Wang A, Wang Y, Wark JS, Warner BE, Watson J, Watt RG, Watts P, Weaver J, Weaver RP, Weaver S, Weber CR, Weber P, Weber SV, Wegner P, Welday B, Welser-Sherrill L, Weiss K, Wharton KB, Wheeler GF, Whistler W, White RK, Whitley HD, Whitman P, Wickett ME, Widmann K, Widmayer C, Wiedwald J, Wilcox R, Wilcox S, Wild C, Wilde BH, Wilde CH, Wilhelmsen K, Wilke MD, Wilkens H, Wilkins P, Wilks SC, Williams EA, Williams GJ, Williams W, Williams WH, Wilson DC, Wilson B, Wilson E, Wilson R, Winters S, Wisoff PJ, Wittman M, Wolfe J, Wong A, Wong KW, Wong L, Wong N, Wood R, Woodhouse D, Woodruff J, Woods DT, Woods S, Woodworth BN, Wooten E, Wootton A, Work K, Workman JB, Wright J, Wu M, Wuest C, Wysocki FJ, Xu H, Yamaguchi M, Yang B, Yang ST, Yatabe J, Yeamans CB, Yee BC, Yi SA, Yin L, Young B, Young CS, Young CV, Young P, Youngblood K, Yu J, Zacharias R, Zagaris G, Zaitseva N, Zaka F, Ze F, Zeiger B, Zika M, Zimmerman GB, Zobrist T, Zuegel JD, and Zylstra AB

Abstract

On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.

Published
2024
Full Text
View/download PDF

36. Beyond EGFR inhibitors in advanced colorectal cancer: Targeting BRAF and HER2.

Author

Dao V and Heestand G

Subjects
Animals, Mice, Humans, Proto-Oncogene Proteins B-raf genetics, Mutation, Panitumumab therapeutic use, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology
Abstract

The addition of antiepidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab or panitumumab, to conventional chemotherapy has improved clinical outcomes for rat sarcoma virus (RAS) wild-type advanced colorectal cancer patients, however, durable responses and 5-year overall survival rates remain limited. BRAF V600E somatic mutation and human epidermal growth factor receptor (HER2) amplification/overexpression have been separately implicated in primary resistance to anti-EGFR therapeutic strategies via aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway, resulting in poorer outcomes. In addition to being a negative predictive biomarker for anti-EGFR therapy, BRAF V600E mutation and HER2 amplification/overexpression serve as positive predictors of response to therapies targeting these respective tumor promoters. This review will highlight key clinical studies that support the rational use of v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) and HER2-targeted therapies, often in combination with other targeted agents, cytotoxic chemotherapy, and immune checkpoint inhibitors. We discuss current challenges with BRAF and HER2-targeted therapies in metastatic colorectal cancer and potential opportunities for improvement., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: GMH: Stock ownership/employment—Roche/Genentech. Consulting—Eisai, Elevation Oncology, Exelixis, (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
Full Text
View/download PDF

37. Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Author

Abu-Shawareb H, Acree R, Adams P, Adams J, Addis B, Aden R, Adrian P, Afeyan BB, Aggleton M, Aghaian L, Aguirre A, Aikens D, Akre J, Albert F, Albrecht M, Albright BJ, Albritton J, Alcala J, Alday C, Alessi DA, Alexander N, Alfonso J, Alfonso N, Alger E, Ali SJ, Ali ZA, Alley WE, Amala P, Amendt PA, Amick P, Ammula S, Amorin C, Ampleford DJ, Anderson RW, Anklam T, Antipa N, Appelbe B, Aracne-Ruddle C, Araya E, Arend M, Arnold P, Arnold T, Asay J, Atherton LJ, Atkinson D, Atkinson R, Auerbach JM, Austin B, Auyang L, Awwal AS, Ayers J, Ayers S, Ayers T, Azevedo S, Bachmann B, Back CA, Bae J, Bailey DS, Bailey J, Baisden T, Baker KL, Baldis H, Barber D, Barberis M, Barker D, Barnes A, Barnes CW, Barrios MA, Barty C, Bass I, Batha SH, Baxamusa SH, Bazan G, Beagle JK, Beale R, Beck BR, Beck JB, Bedzyk M, Beeler RG, Beeler RG, Behrendt W, Belk L, Bell P, Belyaev M, Benage JF, Bennett G, Benedetti LR, Benedict LX, Berger R, Bernat T, Bernstein LA, Berry B, Bertolini L, Besenbruch G, Betcher J, Bettenhausen R, Betti R, Bezzerides B, Bhandarkar SD, Bickel R, Biener J, Biesiada T, Bigelow K, Bigelow-Granillo J, Bigman V, Bionta RM, Birge NW, Bitter M, Black AC, Bleile R, Bleuel DL, Bliss E, Bliss E, Blue B, Boehly T, Boehm K, Boley CD, Bonanno R, Bond EJ, Bond T, Bonino MJ, Borden M, Bourgade JL, Bousquet J, Bowers J, Bowers M, Boyd R, Bozek A, Bradley DK, Bradley KS, Bradley PA, Bradley L, Brannon L, Brantley PS, Braun D, Braun T, Brienza-Larsen K, Briggs TM, Britten J, Brooks ED, Browning D, Bruhn MW, Brunner TA, Bruns H, Brunton G, Bryant B, Buczek T, Bude J, Buitano L, Burkhart S, Burmark J, Burnham A, Burr R, Busby LE, Butlin B, Cabeltis R, Cable M, Cabot WH, Cagadas B, Caggiano J, Cahayag R, Caldwell SE, Calkins S, Callahan DA, Calleja-Aguirre J, Camara L, Camp D, Campbell EM, Campbell JH, Carey B, Carey R, Carlisle K, Carlson L, Carman L, Carmichael J, Carpenter A, Carr C, Carrera JA, Casavant D, Casey A, Casey DT, Castillo A, Castillo E, Castor JI, Castro C, Caughey W, Cavitt R, Celeste J, Celliers PM, Cerjan C, Chandler G, Chang B, Chang C, Chang J, Chang L, Chapman R, Chapman T, Chase L, Chen H, Chen H, Chen K, Chen LY, Cheng B, Chittenden J, Choate C, Chou J, Chrien RE, Chrisp M, Christensen K, Christensen M, Christopherson AR, Chung M, Church JA, Clark A, Clark DS, Clark K, Clark R, Claus L, Cline B, Cline JA, Cobble JA, Cochrane K, Cohen B, Cohen S, Collette MR, Collins G, Collins LA, Collins TJB, Conder A, Conrad B, Conyers M, Cook AW, Cook D, Cook R, Cooley JC, Cooper G, Cope T, Copeland SR, Coppari F, Cortez J, Cox J, Crandall DH, Crane J, Craxton RS, Cray M, Crilly A, Crippen JW, Cross D, Cuneo M, Cuotts G, Czajka CE, Czechowicz D, Daly T, Danforth P, Darbee R, Darlington B, Datte P, Dauffy L, Davalos G, Davidovits S, Davis P, Davis J, Dawson S, Day RD, Day TH, Dayton M, Deck C, Decker C, Deeney C, DeFriend KA, Deis G, Delamater ND, Delettrez JA, Demaret R, Demos S, Dempsey SM, Desjardin R, Desjardins T, Desjarlais MP, Dewald EL, DeYoreo J, Diaz S, Dimonte G, Dittrich TR, Divol L, Dixit SN, Dixon J, Dodd ES, Dolan D, Donovan A, Donovan M, Döppner T, Dorrer C, Dorsano N, Douglas MR, Dow D, Downie J, Downing E, Dozieres M, Draggoo V, Drake D, Drake RP, Drake T, Dreifuerst G, DuBois DF, DuBois PF, Dunham G, Dylla-Spears R, Dymoke-Bradshaw AKL, Dzenitis B, Ebbers C, Eckart M, Eddinger S, Eder D, Edgell D, Edwards MJ, Efthimion P, Eggert JH, Ehrlich B, Ehrmann P, Elhadj S, Ellerbee C, Elliott NS, Ellison CL, Elsner F, Emerich M, Engelhorn K, England T, English E, Epperson P, Epstein R, Erbert G, Erickson MA, Erskine DJ, Erlandson A, Espinosa RJ, Estes C, Estabrook KG, Evans S, Fabyan A, Fair J, Fallejo R, Farmer N, Farmer WA, Farrell M, Fatherley VE, Fedorov M, Feigenbaum E, Feit M, Ferguson W, Fernandez JC, Fernandez-Panella A, Fess S, Field JE, Filip CV, Fincke JR, Finn T, Finnegan SM, Finucane RG, Fischer M, Fisher A, Fisher J, Fishler B, Fittinghoff D, Fitzsimmons P, Flegel M, Flippo KA, Florio J, Folta J, Folta P, Foreman LR, Forrest C, Forsman A, Fooks J, Foord M, Fortner R, Fournier K, Fratanduono DE, Frazier N, Frazier T, Frederick C, Freeman MS, Frenje J, Frey D, Frieders G, Friedrich S, Froula DH, Fry J, Fuller T, Gaffney J, Gales S, Le Galloudec B, Le Galloudec KK, Gambhir A, Gao L, Garbett WJ, Garcia A, Gates C, Gaut E, Gauthier P, Gavin Z, Gaylord J, Geissel M, Génin F, Georgeson J, Geppert-Kleinrath H, Geppert-Kleinrath V, Gharibyan N, Gibson J, Gibson C, Giraldez E, Glebov V, Glendinning SG, Glenn S, Glenzer SH, Goade S, Gobby PL, Goldman SR, Golick B, Gomez M, Goncharov V, Goodin D, Grabowski P, Grafil E, Graham P, Grandy J, Grasz E, Graziani F, Greenman G, Greenough JA, Greenwood A, Gregori G, Green T, Griego JR, Grim GP, Grondalski J, Gross S, Guckian J, Guler N, Gunney B, Guss G, Haan S, Hackbarth J, Hackel L, Hackel R, Haefner C, Hagmann C, Hahn KD, Hahn S, Haid BJ, Haines BM, Hall BM, Hall C, Hall GN, Hamamoto M, Hamel S, Hamilton CE, Hammel BA, Hammer JH, Hampton G, Hamza A, Handler A, Hansen S, Hanson D, Haque R, Harding D, Harding E, Hares JD, Harris DB, Harte JA, Hartouni EP, Hatarik R, Hatchett S, Hauer AA, Havre M, Hawley R, Hayes J, Hayes J, Hayes S, Hayes-Sterbenz A, Haynam CA, Haynes DA, Headley D, Heal A, Heebner JE, Heerey S, Heestand GM, Heeter R, Hein N, Heinbockel C, Hendricks C, Henesian M, Heninger J, Henrikson J, Henry EA, Herbold EB, Hermann MR, Hermes G, Hernandez JE, Hernandez VJ, Herrmann MC, Herrmann HW, Herrera OD, Hewett D, Hibbard R, Hicks DG, Hill D, Hill K, Hilsabeck T, Hinkel DE, Ho DD, Ho VK, Hoffer JK, Hoffman NM, Hohenberger M, Hohensee M, Hoke W, Holdener D, Holdener F, Holder JP, Holko B, Holunga D, Holzrichter JF, Honig J, Hoover D, Hopkins D, Berzak Hopkins L, Hoppe M, Hoppe ML, Horner J, Hornung R, Horsfield CJ, Horvath J, Hotaling D, House R, Howell L, Hsing WW, Hu SX, Huang H, Huckins J, Hui H, Humbird KD, Hund J, Hunt J, Hurricane OA, Hutton M, Huynh KH, Inandan L, Iglesias C, Igumenshchev IV, Izumi N, Jackson M, Jackson J, Jacobs SD, James G, Jancaitis K, Jarboe J, Jarrott LC, Jasion D, Jaquez J, Jeet J, Jenei AE, Jensen J, Jimenez J, Jimenez R, Jobe D, Johal Z, Johns HM, Johnson D, Johnson MA, Gatu Johnson M, Johnson RJ, Johnson S, Johnson SA, Johnson T, Jones K, Jones O, Jones M, Jorge R, Jorgenson HJ, Julian M, Jun BI, Jungquist R, Kaae J, Kabadi N, Kaczala D, Kalantar D, Kangas K, Karasiev VV, Karasik M, Karpenko V, Kasarky A, Kasper K, Kauffman R, Kaufman MI, Keane C, Keaty L, Kegelmeyer L, Keiter PA, Kellett PA, Kellogg J, Kelly JH, Kemic S, Kemp AJ, Kemp GE, Kerbel GD, Kershaw D, Kerr SM, Kessler TJ, Key MH, Khan SF, Khater H, Kiikka C, Kilkenny J, Kim Y, Kim YJ, Kimko J, Kimmel M, Kindel JM, King J, Kirkwood RK, Klaus L, Klem D, Kline JL, Klingmann J, Kluth G, Knapp P, Knauer J, Knipping J, Knudson M, Kobs D, Koch J, Kohut T, Kong C, Koning JM, Koning P, Konior S, Kornblum H, Kot LB, Kozioziemski B, Kozlowski M, Kozlowski PM, Krammen J, Krasheninnikova NS, Kraus B, Krauser W, Kress JD, Kritcher AL, Krieger E, Kroll JJ, Kruer WL, Kruse MKG, Kucheyev S, Kumbera M, Kumpan S, Kunimune J, Kustowski B, Kwan TJT, Kyrala GA, Laffite S, Lafon M, LaFortune K, Lahmann B, Lairson B, Landen OL, Langenbrunner J, Lagin L, Land T, Lane M, Laney D, Langdon AB, Langer SH, Langro A, Lanier NE, Lanier TE, Larson D, Lasinski BF, Lassle D, LaTray D, Lau G, Lau N, Laumann C, Laurence A, Laurence TA, Lawson J, Le HP, Leach RR, Leal L, Leatherland A, LeChien K, Lechleiter B, Lee A, Lee M, Lee T, Leeper RJ, Lefebvre E, Leidinger JP, LeMire B, Lemke RW, Lemos NC, Le Pape S, Lerche R, Lerner S, Letts S, Levedahl K, Lewis T, Li CK, Li H, Li J, Liao W, Liao ZM, Liedahl D, Liebman J, Lindford G, Lindman EL, Lindl JD, Loey H, London RA, Long F, Loomis EN, Lopez FE, Lopez H, Losbanos E, Loucks S, Lowe-Webb R, Lundgren E, Ludwigsen AP, Luo R, Lusk J, Lyons R, Ma T, Macallop Y, MacDonald MJ, MacGowan BJ, Mack JM, Mackinnon AJ, MacLaren SA, MacPhee AG, Magelssen GR, Magoon J, Malone RM, Malsbury T, Managan R, Mancini R, Manes K, Maney D, Manha D, Mannion OM, Manuel AM, Mapoles E, Mara G, Marcotte T, Marin E, Marinak MM, Mariscal C, Mariscal DA, Mariscal EF, Marley EV, Marozas JA, Marquez R, Marshall CD, Marshall FJ, Marshall M, Marshall S, Marticorena J, Martinez D, Maslennikov I, Mason D, Mason RJ, Masse L, Massey W, Masson-Laborde PE, Masters ND, Mathisen D, Mathison E, Matone J, Matthews MJ, Mattoon C, Mattsson TR, Matzen K, Mauche CW, Mauldin M, McAbee T, McBurney M, Mccarville T, McCrory RL, McEvoy AM, McGuffey C, Mcinnis M, McKenty P, McKinley MS, McLeod JB, McPherson A, Mcquillan B, Meamber M, Meaney KD, Meezan NB, Meissner R, Mehlhorn TA, Mehta NC, Menapace J, Merrill FE, Merritt BT, Merritt EC, Meyerhofer DD, Mezyk S, Mich RJ, Michel PA, Milam D, Miller C, Miller D, Miller DS, Miller E, Miller EK, Miller J, Miller M, Miller PE, Miller T, Miller W, Miller-Kamm V, Millot M, Milovich JL, Minner P, Miquel JL, Mitchell S, Molvig K, Montesanti RC, Montgomery DS, Monticelli M, Montoya A, Moody JD, Moore AS, Moore E, Moran M, Moreno JC, Moreno K, Morgan BE, Morrow T, Morton JW, Moses E, Moy K, Muir R, Murillo MS, Murray JE, Murray JR, Munro DH, Murphy TJ, Munteanu FM, Nafziger J, Nagayama T, Nagel SR, Nast R, Negres RA, Nelson A, Nelson D, Nelson J, Nelson S, Nemethy S, Neumayer P, Newman K, Newton M, Nguyen H, Di Nicola JG, Di Nicola P, Niemann C, Nikroo A, Nilson PM, Nobile A, Noorai V, Nora R, Norton M, Nostrand M, Note V, Novell S, Nowak PF, Nunez A, Nyholm RA, O'Brien M, Oceguera A, Oertel JA, Okui J, Olejniczak B, Oliveira J, Olsen P, Olson B, Olson K, Olson RE, Opachich YP, Orsi N, Orth CD, Owen M, Padalino S, Padilla E, Paguio R, Paguio S, Paisner J, Pajoom S, Pak A, Palaniyappan S, Palma K, Pannell T, Papp F, Paras D, Parham T, Park HS, Pasternak A, Patankar S, Patel MV, Patel PK, Patterson R, Patterson S, Paul B, Paul M, Pauli E, Pearce OT, Pearcy J, Pedrotti B, Peer A, Pelz LJ, Penetrante B, Penner J, Perez A, Perkins LJ, Pernice E, Perry TS, Person S, Petersen D, Petersen T, Peterson DL, Peterson EB, Peterson JE, Peterson JL, Peterson K, Peterson RR, Petrasso RD, Philippe F, Phipps TJ, Piceno E, Ping Y, Pickworth L, Pino J, Plummer R, Pollack GD, Pollaine SM, Pollock BB, Ponce D, Ponce J, Pontelandolfo J, Porter JL, Post J, Poujade O, Powell C, Powell H, Power G, Pozulp M, Prantil M, Prasad M, Pratuch S, Price S, Primdahl K, Prisbrey S, Procassini R, Pruyne A, Pudliner B, Qiu SR, Quan K, Quinn M, Quintenz J, Radha PB, Rainer F, Ralph JE, Raman KS, Raman R, Rambo P, Rana S, Randewich A, Rardin D, Ratledge M, Ravelo N, Ravizza F, Rayce M, Raymond A, Raymond B, Reed B, Reed C, Regan S, Reichelt B, Reis V, Reisdorf S, Rekow V, Remington BA, Rendon A, Requieron W, Rever M, Reynolds H, Reynolds J, Rhodes J, Rhodes M, Richardson MC, Rice B, Rice NG, Rieben R, Rigatti A, Riggs S, Rinderknecht HG, Ring K, Riordan B, Riquier R, Rivers C, Roberts D, Roberts V, Robertson G, Robey HF, Robles J, Rocha P, Rochau G, Rodriguez J, Rodriguez S, Rosen M, Rosenberg M, Ross G, Ross JS, Ross P, Rouse J, Rovang D, Rubenchik AM, Rubery MS, Ruiz CL, Rushford M, Russ B, Rygg JR, Ryujin BS, Sacks RA, Sacks RF, Saito K, Salmon T, Salmonson JD, Sanchez J, Samuelson S, Sanchez M, Sangster C, Saroyan A, Sater J, Satsangi A, Sauers S, Saunders R, Sauppe JP, Sawicki R, Sayre D, Scanlan M, Schaffers K, Schappert GT, Schiaffino S, Schlossberg DJ, Schmidt DW, Schmitt MJ, Schneider DHG, Schneider MB, Schneider R, Schoff M, Schollmeier M, Schölmerich M, Schroeder CR, Schrauth SE, Scott HA, Scott I, Scott JM, Scott RHH, Scullard CR, Sedillo T, Seguin FH, Seka W, Senecal J, Sepke SM, Seppala L, Sequoia K, Severyn J, Sevier JM, Sewell N, Seznec S, Shah RC, Shamlian J, Shaughnessy D, Shaw M, Shaw R, Shearer C, Shelton R, Shen N, Sherlock MW, Shestakov AI, Shi EL, Shin SJ, Shingleton N, Shmayda W, Shor M, Shoup M, Shuldberg C, Siegel L, Silva FJ, Simakov AN, Sims BT, Sinars D, Singh P, Sio H, Skulina K, Skupsky S, Slutz S, Sluyter M, Smalyuk VA, Smauley D, Smeltser RM, Smith C, Smith I, Smith J, Smith L, Smith R, Sohn R, Sommer S, Sorce C, Sorem M, Soures JM, Spaeth ML, Spears BK, Speas S, Speck D, Speck R, Spears J, Spinka T, Springer PT, Stadermann M, Stahl B, Stahoviak J, Stanton LG, Steele R, Steele W, Steinman D, Stemke R, Stephens R, Sterbenz S, Sterne P, Stevens D, Stevers J, Still CB, Stoeckl C, Stoeffl W, Stolken JS, Stolz C, Storm E, Stone G, Stoupin S, Stout E, Stowers I, Strauser R, Streckart H, Streit J, Strozzi DJ, Suratwala T, Sutcliffe G, Suter LJ, Sutton SB, Svidzinski V, Swadling G, Sweet W, Szoke A, Tabak M, Takagi M, Tambazidis A, Tang V, Taranowski M, Taylor LA, Telford S, Theobald W, Thi M, Thomas A, Thomas CA, Thomas I, Thomas R, Thompson IJ, Thongstisubskul A, Thorsness CB, Tietbohl G, Tipton RE, Tobin M, Tomlin N, Tommasini R, Toreja AJ, Torres J, Town RPJ, Townsend S, Trenholme J, Trivelpiece A, Trosseille C, Truax H, Trummer D, Trummer S, Truong T, Tubbs D, Tubman ER, Tunnell T, Turnbull D, Turner RE, Ulitsky M, Upadhye R, Vaher JL, VanArsdall P, VanBlarcom D, Vandenboomgaerde M, VanQuinlan R, Van Wonterghem BM, Varnum WS, Velikovich AL, Vella A, Verdon CP, Vermillion B, Vernon S, Vesey R, Vickers J, Vignes RM, Visosky M, Vocke J, Volegov PL, Vonhof S, Von Rotz R, Vu HX, Vu M, Wall D, Wall J, Wallace R, Wallin B, Walmer D, Walsh CA, Walters CF, Waltz C, Wan A, Wang A, Wang Y, Wark JS, Warner BE, Watson J, Watt RG, Watts P, Weaver J, Weaver RP, Weaver S, Weber CR, Weber P, Weber SV, Wegner P, Welday B, Welser-Sherrill L, Weiss K, Widmann K, Wheeler GF, Whistler W, White RK, Whitley HD, Whitman P, Wickett ME, Widmayer C, Wiedwald J, Wilcox R, Wilcox S, Wild C, Wilde BH, Wilde CH, Wilhelmsen K, Wilke MD, Wilkens H, Wilkins P, Wilks SC, Williams EA, Williams GJ, Williams W, Williams WH, Wilson DC, Wilson B, Wilson E, Wilson R, Winters S, Wisoff J, Wittman M, Wolfe J, Wong A, Wong KW, Wong L, Wong N, Wood R, Woodhouse D, Woodruff J, Woods DT, Woods S, Woodworth BN, Wooten E, Wootton A, Work K, Workman JB, Wright J, Wu M, Wuest C, Wysocki FJ, Xu H, Yamaguchi M, Yang B, Yang ST, Yatabe J, Yeamans CB, Yee BC, Yi SA, Yin L, Young B, Young CS, Young CV, Young P, Youngblood K, Zacharias R, Zagaris G, Zaitseva N, Zaka F, Ze F, Zeiger B, Zika M, Zimmerman GB, Zobrist T, Zuegel JD, and Zylstra AB

Abstract

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.

Published
2022
Full Text
View/download PDF

38. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma.

Author

Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick JK, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, and Kurzrock R

Subjects
Adult, Aged, Carcinoma, Hepatocellular pathology, Female, Humans, Male, Middle Aged, Prospective Studies, Biomarkers, Tumor genetics, Carcinoma, Hepatocellular genetics, Circulating Tumor DNA genetics, High-Throughput Nucleotide Sequencing methods
Abstract

Background: Because imaging has a high sensitivity to diagnose hepatocellular carcinoma (HCC) and tissue biopsies carry risks such as bleeding, the latter are often not performed in HCC. Blood-derived circulating tumor DNA (ctDNA) analysis can identify somatic alterations, but its utility has not been characterized in HCC., Materials and Methods: We evaluated 14 patients with advanced HCC (digital ctDNA sequencing [68 genes]). Mutant relative to wild-type allele fraction was calculated., Results: All patients (100%) had somatic alterations (median = 3 alterations/patient [range, 1-8]); median mutant allele fraction, 0.29% (range, 0.1%-37.77%). Mutations were identified in several genes: TP53 (57% of patients), CTNNB1 (29%), PTEN (7%), CDKN2A (7%), ARID1A (7%), and MET (7%); amplifications, in CDK6 (14%), EGFR (14%), MYC (14%), BRAF (7%), RAF1 (7%), FGFR1 (7%), CCNE1 (7%), PIK3CA (7%), and ERBB2/HER2 (7%). Eleven patients (79%) had ≥1 theoretically actionable alteration. No two patients had identical genomic portfolios, suggesting the need for customized treatment. A patient with a CDKN2A -inactivating and a CTNNB1 -activating mutation received matched treatment: palbociclib (CDK4/6 inhibitor) and celecoxib (COX-2/Wnt inhibitor); des-gamma-carboxy prothrombin level decreased by 84% at 2 months (1,410 to 242 ng/mL [normal: ≤7.4 ng/mL]; alpha fetoprotein [AFP] low at baseline). A patient with a PTEN -inactivating and a MET -activating mutation (an effect suggested by in silico molecular dynamic simulations) received sirolimus (mechanistic target of rapamycin inhibitor) and cabozantinib (MET inhibitor); AFP declined by 63% (8,320 to 3,045 ng/mL [normal: 0-15 ng/mL])., Conclusion: ctDNA derived from noninvasive blood tests can provide exploitable genomic profiles in patients with HCC., Implications for Practice: This study reports that blood-derived circulating tumor DNA can provide therapeutically exploitable genomic profiles in hepatocellular cancer, a malignancy that is known to be difficult to biopsy., Competing Interests: Disclosures of potential conflicts of interest may be found at the end of this article., (© AlphaMed Press 2018.)

Published
2018
Full Text
View/download PDF

39. A Novel Biomarker Panel Examining Response to Gemcitabine with or without Erlotinib for Pancreatic Cancer Therapy in NCIC Clinical Trials Group PA.3.

Author

Shultz DB, Pai J, Chiu W, Ng K, Hellendag MG, Heestand G, Chang DT, Tu D, Moore MJ, Parulekar WR, and Koong AC

Subjects
Antineoplastic Agents administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine therapeutic use, Double-Blind Method, Erlotinib Hydrochloride administration & dosage, Humans, Placebos, Gemcitabine, Antineoplastic Agents therapeutic use, Biomarkers, Tumor blood, Deoxycytidine analogs & derivatives, Erlotinib Hydrochloride therapeutic use, Pancreatic Neoplasms drug therapy
Abstract

Purpose: NCIC Clinical Trials Group PA.3 was a randomized control trial that demonstrated improved overall survival (OS) in patients receiving erlotinib in addition to gemcitabine for locally advanced or metastatic pancreatic cancer. Prior to therapy, patients had plasma samples drawn for future study. We sought to identify biomarkers within these samples., Experimental Design: Using the proximity ligation assay (PLA), a probe panel was built from commercially available antibodies for 35 key proteins selected from a global genetic analysis of pancreatic cancers, and used to quantify protein levels in 20 uL of patient plasma. To determine if any of these proteins levels independently associated with OS, univariate and mulitbaraible Cox models were used. In addition, we examined the associations between biomarker expression and disease stage at diagnosis using Fisher's exact test. The correlation between Erlotinib sensitivity and each biomarkers was assessed using a test of interaction between treatment and biomarker., Results and Conclusion: Of the 569 eligible patients, 480 had samples available for study. Samples were randomly allocated into training (251) and validation sets (229). Among all patients, elevated levels of interleukin-8 (IL-8), carcinoembryonic antigen (CEA), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and interleukin-6 were independently associated with lower OS, while IL-8, CEA, platelet-derived growth factor receptor alpha and mucin-1 were associated with metastatic disease. Patients with elevated levels of receptor tyrosine-protein kinase erbB-2 (HER2) expression had improved OS when treated with erlotinib compared to placebo. In conclusion, PLA is a powerful tool for identifying biomarkers from archived, small volume serum samples. These data may be useful to stratify patient outcomes regardless of therapeutic intervention., Trial Registration: ClinicalTrials.gov NCT00040183.

Published
2016
Full Text
View/download PDF

40. Racial disparity in consultation, treatment, and the impact on survival in metastatic colorectal cancer.

Author

Simpson DR, Martínez ME, Gupta S, Hattangadi-Gluth J, Mell LK, Heestand G, Fanta P, Ramamoorthy S, Le QT, and Murphy JD

Subjects
Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant statistics & numerical data, Colorectal Neoplasms pathology, Female, Humans, Kaplan-Meier Estimate, Male, Medical Oncology statistics & numerical data, Medical Record Linkage, Medicare, Neoplasm Staging, Radiotherapy, Adjuvant statistics & numerical data, SEER Program, Treatment Outcome, United States epidemiology, Black or African American statistics & numerical data, Colorectal Neoplasms mortality, Colorectal Neoplasms therapy, Combined Modality Therapy statistics & numerical data, Healthcare Disparities statistics & numerical data, Referral and Consultation statistics & numerical data, White People statistics & numerical data
Abstract

Background: Black patients with metastatic colorectal cancer have inferior survival compared to white patients. The purpose of this study was to examine disparity in specialist consultation and multimodality treatment and the impact that treatment inequality has on survival., Methods: We identified 9935 non-Hispanic white and 1281 black patients with stage IV colorectal cancer aged 66 years and older from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Logistic regression models identified race-based differences in consultation rates and subsequent treatment with surgery, chemotherapy, or radiation. Multivariable Cox regression models identified potential factors that explain race-based survival differences. All statistical tests were two-sided., Results: Black patients had lower rates of consultation with surgery, medical oncology, and radiation oncology. Among patients seen in consultation, black patients received less surgery directed at the primary tumor, liver- or lung-directed surgery, chemotherapy, and radiotherapy. Unadjusted survival analysis found a 15% higher chance of dying for black patients compared with white patients (hazard ratio [HR] = 1.15; 95% confidence interval (CI) = 1.08 to 1.22; P < .001). Adjustment for patient, tumor, and demographic variables marginally reduced the risk of death (HR = 1.08; 95% CI = 1.01 to 1.15; P = .03). After adjustment for differences in treatment, the increased risk of death for black patients disappeared., Conclusions: Our study shows racial disparity in specialist consultation as well as subsequent treatment with multimodality therapy for metastatic colorectal cancer, and it suggests that inferior survival for black patients may stem from this treatment disparity. Further research into the underlying causes of this inequality will improve access to treatment and survival in metastatic colorectal cancer.

Published
2013
Full Text
View/download PDF

41. Demonstration of high-energy 2 omega (526.5 nm) operation on the National Ignition Facility Laser System.

Author

Heestand GM, Haynam CA, Wegner PJ, Bowers MW, Dixit SN, Erbert GV, Henesian MA, Hermann MR, Jancaitis KS, Knittel K, Kohut T, Lindl JD, Manes KR, Marshall CD, Mehta NC, Menapace J, Moses E, Murray JR, Nostrand MC, Orth CD, Patterson R, Sacks RA, Saunders R, Shaw MJ, Spaeth M, Sutton SB, Williams WH, Widmayer CC, White RK, Whitman PK, Yang ST, and Van Wonterghem BM

Abstract

A single beamline of the National Ignition Facility (NIF) has been operated at a wavelength of 526.5 nm (2 omega) by frequency converting the fundamental 1053 nm (1 omega) wavelength with an 18.2 mm thick type-I potassium dihydrogen phosphate (KDP) second-harmonic generator (SHG) crystal. Second-harmonic energies of up to 17.9 kJ were measured at the final optics focal plane with a conversion efficiency of 82%. For a similarly configured 192-beam NIF, this scales to a total 2 omega energy of 3.4 MJ full NIF equivalent (FNE).

Published
2008
Full Text
View/download PDF

42. Gallstone-induced inflammatory fibrosis: a relentless clinical course of retained gallstones after laparoscopic cholecystectomy.

Author

Heestand G, Morrison B, Correa A, Palmer S, Mateo R, Hagen J, Genyk Y, Selby R, and Sher L

Subjects
Aged, Female, Fibrosis, Humans, Treatment Failure, Abdomen pathology, Abdominal Abscess etiology, Cholecystectomy, Laparoscopic adverse effects, Gallstones surgery, Staphylococcal Infections etiology, Streptococcal Infections etiology
Abstract

Multiple reports in the literature confirm that retained gallstones spilled during laparoscopic cholecystectomy perpetuate chronic inflammation and suppuration long after the initial operation. Two patients who had previously undergone laparoscopic cholecystectomy presented to our institution with complications of retained stones. Patient 1 presented with right upper quadrant pain and a mass involving the right hepatic lobe. Patient 2 presented with a draining right flank abscess. Both underwent exploratory laparotomy at which time multiple abscess cavities were found, many of which contained retained gallstones. Patient 1 required reoperation for recurrent abscesses 7 months after the initial procedure and has been disease free for 6 months. Patient 2 had abscess recurrence that required percutaneous drainage 1 year after the original procedure and has not had recurrence for 4 years.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results