Search

Your search keyword '"Heery, Christopher"' showing total 330 results
Start Over Author "Heery, Christopher"
330 results on '"Heery, Christopher"'

3. A phase 2 study of a brachyury‐targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma.

Author

Cote, Gregory M., Conley, Anthony P., Attia, Steven, Van Tine, Brian A., Seetharam, Mahesh, Chen, Yen‐Lin, Gafoor, Zarina, Heery, Christopher, Pico‐Navarro, Cesar, and Adams, Tatiana

Subjects
COMBINED vaccines, VACCINIA, DISEASE progression, SURVIVAL rate, CONFIDENCE intervals, CHORDOMA
Abstract

Background: This was a single‐arm, phase 2 clinical trial of Bavarian Nordic (BN)‐Brachyury vaccine plus radiotherapy (RT) designed to determine the objective response rate (ORR), progression‐free survival (PFS), and safety of the combination in chordoma. Methods: A total of 29 adult patients with advanced chordoma were treated with two subcutaneous priming vaccine doses of modified vaccinia Ankara‐Bavarian Nordic (MVA‐BN)‐Brachyury and one vaccine dose of fowlpox virus (FPV)‐Brachyury before RT. After RT, booster vaccinations were given with FPV‐Brachyury every 4 weeks for 4 doses, then every 12 weeks (week 110). A minimum RT dose of >8 Gy in one fraction for each target was required. Response was evaluated by modified Response Evaluation Criteria in Solid Tumors 1.1 (mRECIST), where only radiated lesions were considered targets, and by standard RECIST 1.1 in a subset of patients. Results: Two of 26 evaluable patients experienced durable partial response (PR) (ORR of 7.7%; 90% confidence interval [CI], 2.6–20.8]) by mRECIST 1.1. A total of 21 patients (80.8%; 90% CI, 65.4–90.3) had stable disease, and three patients (11.5%; 90% CI, 4.7–25.6) had progressive disease as best response per mRECIST 1.1. Median PFS was not reached during the study. Conclusions: This trial confirms the safety of BN‐Brachyury and RT. Although the study did not meet the predefined study goal of four responses in 29 patients, we did observe two PRs and a PFS of greater than 2 years. For a vaccine‐based study in chordoma, an ultra‐rare disease where response rates are low, a randomized study or novel trial designs may be required to confirm activity. This clinical trial confirms the safety of the combination of the Bavarian Nordic‐Brachyury vaccine and radiation. The authors observed two partial responses. Although the objective response rate was low, they observed a progression‐free survival rate of greater than 2 years. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Avelumab in Patients With Metastatic Colorectal Cancer

Author

Redman, Jason M, primary, O’Sullivan Coyne, Geraldine, additional, Reed, Clay T, additional, Madan, Ravi A, additional, Strauss, Julius, additional, Steinberg, Seth J, additional, Marté, Jennifer, additional, Cordes, Lisa, additional, Heery, Christopher, additional, and Gulley, James L, additional

Published
2023
Full Text
View/download PDF

5. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial

Author

Heery, Christopher R, O'Sullivan-Coyne, Geraldine, Madan, Ravi A, Cordes, Lisa, Rajan, Arun, Rauckhorst, Myrna, Lamping, Elizabeth, Oyelakin, Israel, Marté, Jennifer L, Lepone, Lauren M, Donahue, Renee N, Grenga, Italia, Cuillerot, Jean-Marie, Neuteboom, Berend, Heydebreck, Anja von, Chin, Kevin, Schlom, Jeffrey, and Gulley, James L

Published
2017
Full Text
View/download PDF

9. Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy

Author

Farsaci, Benedetto, primary, Donahue, Renee N., primary, Grenga, Italia, primary, Lepone, Lauren M., primary, Kim, Peter S., primary, Dempsey, Brendan, primary, Siebert, Janet C., primary, Ibrahim, Nuhad K., primary, Madan, Ravi A., primary, Heery, Christopher R., primary, Gulley, James L., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Materials and Methods from Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy

Author

Farsaci, Benedetto, primary, Donahue, Renee N., primary, Grenga, Italia, primary, Lepone, Lauren M., primary, Kim, Peter S., primary, Dempsey, Brendan, primary, Siebert, Janet C., primary, Ibrahim, Nuhad K., primary, Madan, Ravi A., primary, Heery, Christopher R., primary, Gulley, James L., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

11. Data from Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury

Author

Heery, Christopher R., primary, Singh, B. Harpreet, primary, Rauckhorst, Myrna, primary, Marté, Jennifer L., primary, Donahue, Renee N., primary, Grenga, Italia, primary, Rodell, Timothy C., primary, Dahut, William, primary, Arlen, Philip M., primary, Madan, Ravi A., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure 3 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Table 1 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

14. Data from A Blueprint to Advance Colorectal Cancer Immunotherapies

Author

Le, Dung T., primary, Hubbard-Lucey, Vanessa M., primary, Morse, Michael A., primary, Heery, Christopher R., primary, Dwyer, Andrea, primary, Marsilje, Thomas H., primary, Brodsky, Arthur N., primary, Chan, Emily, primary, Deming, Dustin A., primary, Diaz, Luis A., primary, Fridman, Wolf H., primary, Goldberg, Richard M., primary, Hamilton, Stanley R., primary, Housseau, Franck, primary, Jaffee, Elizabeth M., primary, Kang, S. Peter, primary, Krishnamurthi, Smitha S., primary, Lieu, Christopher H., primary, Messersmith, Wells, primary, Sears, Cynthia L., primary, Segal, Neil H., primary, Yang, Arvin, primary, Moss, Rebecca A., primary, Cha, Edward, primary, O'Donnell-Tormey, Jill, primary, Roach, Nancy, primary, Davis, Anjelica Q., primary, McAbee, Keavy, primary, Worrall, Sharyn, primary, and Benson, Al B., primary

Published
2023
Full Text
View/download PDF

15. Supplemental Table 2 from A Blueprint to Advance Colorectal Cancer Immunotherapies

Author

Le, Dung T., primary, Hubbard-Lucey, Vanessa M., primary, Morse, Michael A., primary, Heery, Christopher R., primary, Dwyer, Andrea, primary, Marsilje, Thomas H., primary, Brodsky, Arthur N., primary, Chan, Emily, primary, Deming, Dustin A., primary, Diaz, Luis A., primary, Fridman, Wolf H., primary, Goldberg, Richard M., primary, Hamilton, Stanley R., primary, Housseau, Franck, primary, Jaffee, Elizabeth M., primary, Kang, S. Peter, primary, Krishnamurthi, Smitha S., primary, Lieu, Christopher H., primary, Messersmith, Wells, primary, Sears, Cynthia L., primary, Segal, Neil H., primary, Yang, Arvin, primary, Moss, Rebecca A., primary, Cha, Edward, primary, O'Donnell-Tormey, Jill, primary, Roach, Nancy, primary, Davis, Anjelica Q., primary, McAbee, Keavy, primary, Worrall, Sharyn, primary, and Benson, Al B., primary

Published
2023
Full Text
View/download PDF

16. Supplemental Table 1 from A Blueprint to Advance Colorectal Cancer Immunotherapies

Author

Le, Dung T., primary, Hubbard-Lucey, Vanessa M., primary, Morse, Michael A., primary, Heery, Christopher R., primary, Dwyer, Andrea, primary, Marsilje, Thomas H., primary, Brodsky, Arthur N., primary, Chan, Emily, primary, Deming, Dustin A., primary, Diaz, Luis A., primary, Fridman, Wolf H., primary, Goldberg, Richard M., primary, Hamilton, Stanley R., primary, Housseau, Franck, primary, Jaffee, Elizabeth M., primary, Kang, S. Peter, primary, Krishnamurthi, Smitha S., primary, Lieu, Christopher H., primary, Messersmith, Wells, primary, Sears, Cynthia L., primary, Segal, Neil H., primary, Yang, Arvin, primary, Moss, Rebecca A., primary, Cha, Edward, primary, O'Donnell-Tormey, Jill, primary, Roach, Nancy, primary, Davis, Anjelica Q., primary, McAbee, Keavy, primary, Worrall, Sharyn, primary, and Benson, Al B., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Table 2 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

19. Supplemental Figure 1 from Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury

Author

Heery, Christopher R., primary, Singh, B. Harpreet, primary, Rauckhorst, Myrna, primary, Marté, Jennifer L., primary, Donahue, Renee N., primary, Grenga, Italia, primary, Rodell, Timothy C., primary, Dahut, William, primary, Arlen, Philip M., primary, Madan, Ravi A., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 2 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

21. Supplemental Table Legends from A Blueprint to Advance Colorectal Cancer Immunotherapies

Author

Le, Dung T., primary, Hubbard-Lucey, Vanessa M., primary, Morse, Michael A., primary, Heery, Christopher R., primary, Dwyer, Andrea, primary, Marsilje, Thomas H., primary, Brodsky, Arthur N., primary, Chan, Emily, primary, Deming, Dustin A., primary, Diaz, Luis A., primary, Fridman, Wolf H., primary, Goldberg, Richard M., primary, Hamilton, Stanley R., primary, Housseau, Franck, primary, Jaffee, Elizabeth M., primary, Kang, S. Peter, primary, Krishnamurthi, Smitha S., primary, Lieu, Christopher H., primary, Messersmith, Wells, primary, Sears, Cynthia L., primary, Segal, Neil H., primary, Yang, Arvin, primary, Moss, Rebecca A., primary, Cha, Edward, primary, O'Donnell-Tormey, Jill, primary, Roach, Nancy, primary, Davis, Anjelica Q., primary, McAbee, Keavy, primary, Worrall, Sharyn, primary, and Benson, Al B., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 1 from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer

Author

Gulley, James L., primary, Madan, Ravi A., primary, Tsang, Kwong Y., primary, Jochems, Caroline, primary, Marté, Jennifer L., primary, Farsaci, Benedetto, primary, Tucker, Jo A., primary, Hodge, James W., primary, Liewehr, David J., primary, Steinberg, Seth M., primary, Heery, Christopher R., primary, and Schlom, Jeffrey, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Data from A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

Author

Gatti-Mays, Margaret E., primary, Strauss, Julius, primary, Donahue, Renee N., primary, Palena, Claudia, primary, Del Rivero, Jaydira, primary, Redman, Jason M., primary, Madan, Ravi A., primary, Marté, Jennifer L., primary, Cordes, Lisa M., primary, Lamping, Elizabeth, primary, Orpia, Alanvin, primary, Burmeister, Andrea, primary, Wagner, Eva, primary, Pico Navarro, Cesar, primary, Heery, Christopher R., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

25. Data from A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

Author

Mohebtash, Mahsa, primary, Tsang, Kwong-Yok, primary, Madan, Ravi A., primary, Huen, Ngar-Yee, primary, Poole, Diane J., primary, Jochems, Caroline, primary, Jones, Jacquin, primary, Ferrara, Theresa, primary, Heery, Christopher R., primary, Arlen, Philip M., primary, Steinberg, Seth M., primary, Pazdur, Mary, primary, Rauckhorst, Myrna, primary, Jones, Elizabeth C., primary, Dahut, William L., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

26. Supplement from Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

Author

Strauss, Julius, primary, Heery, Christopher R., primary, Schlom, Jeffrey, primary, Madan, Ravi A., primary, Cao, Liang, primary, Kang, Zhigang, primary, Lamping, Elizabeth, primary, Marté, Jennifer L., primary, Donahue, Renee N., primary, Grenga, Italia, primary, Cordes, Lisa, primary, Christensen, Olaf, primary, Mahnke, Lisa, primary, Helwig, Christoph, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

27. Figure S1 from Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury

Author

Heery, Christopher R., primary, Palena, Claudia, primary, McMahon, Sheri, primary, Donahue, Renee N., primary, Lepone, Lauren M., primary, Grenga, Italia, primary, Dirmeier, Ulrike, primary, Cordes, Lisa, primary, Marté, Jenn, primary, Dahut, William, primary, Singh, Harpreet, primary, Madan, Ravi A., primary, Fernando, Romaine I., primary, Hamilton, Duane H., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figures and Tables from First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

Author

Strauss, Julius, primary, Heery, Christopher R., primary, Kim, Joseph W., primary, Jochems, Caroline, primary, Donahue, Renee N., primary, Montgomery, Agnes S., primary, McMahon, Sheri, primary, Lamping, Elizabeth, primary, Marté, Jennifer L., primary, Madan, Ravi A., primary, Bilusic, Marijo, primary, Silver, Matthew R., primary, Bertotti, Elisa, primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Figure 1 from A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

Author

Mohebtash, Mahsa, primary, Tsang, Kwong-Yok, primary, Madan, Ravi A., primary, Huen, Ngar-Yee, primary, Poole, Diane J., primary, Jochems, Caroline, primary, Jones, Jacquin, primary, Ferrara, Theresa, primary, Heery, Christopher R., primary, Arlen, Philip M., primary, Steinberg, Seth M., primary, Pazdur, Mary, primary, Rauckhorst, Myrna, primary, Jones, Elizabeth C., primary, Dahut, William L., primary, Schlom, Jeffrey, primary, and Gulley, James L., primary

Published
2023
Full Text
View/download PDF

30. Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma

Author

Rajan, Arun, Heery, Christopher R., Thomas, Anish, Mammen, Andrew L., Perry, Susan, O’Sullivan Coyne, Geraldine, Guha, Udayan, Berman, Arlene, Szabo, Eva, Madan, Ravi A., Ballester, Leomar Y., Pittaluga, Stefania, Donahue, Renee N., Tsai, Yo-Ting, Lepone, Lauren M., Chin, Kevin, Ginty, Fiona, Sood, Anup, Hewitt, Stephen M., Schlom, Jeffrey, Hassan, Raffit, and Gulley, James L.

Published
2019
Full Text
View/download PDF

34. Phase 1 Study of CART-Ddbcma for the Treatment of Subjects with Relapsed and /or Refractory Multiple Myeloma

Author

Frigault, Matthew, primary, Rosenblatt, Jacalyn, additional, Dhakal, Binod, additional, Raje, Noopur, additional, Cook, Daniella, additional, Gaballa, Mahmoud R., additional, Emmanuel-Alejandro, Estelle, additional, Nissen, Danielle, additional, Cornwell, Christine, additional, Banerjee, Kamalika, additional, Rotte, Anand, additional, Heery, Christopher R., additional, Avigan, David, additional, Jakubowiak, Andrzej, additional, and Bishop, Michael R., additional

Published
2022
Full Text
View/download PDF

41. Phase 1 study of CART-ddBCMA in relapsed or refractory multiple myeloma.

Author

Frigault, Matthew J., primary, Rosenblatt, Jacalyn, additional, Cook, Daniella, additional, Cho, Ha Na, additional, Depinho, Gabriel D., additional, Logan, Emma, additional, Liegel, Jessica, additional, Prabhakar, Yougeesh, additional, Cornwell, Christine, additional, Banerjee, Kamalika, additional, Rotte, Anand, additional, Heery, Christopher Ryan, additional, Avigan, David, additional, Jakubowiak, Andrzej J., additional, and Bishop, Michael Russell, additional

Published
2022
Full Text
View/download PDF

43. Phase 1 Study of CART-ddBCMA for the treatment of subjects with relapsed and refractory multiple myeloma

Author

Frigault, Matthew J, primary, Bishop, Michael R., additional, Rosenblatt, Jacalyn, additional, O'Donnell, Elizabeth, additional, Raje, Noopur, additional, Cook, Daniella, additional, Yee, Andrew J., additional, Logan, Emma, additional, Avigan, David, additional, Jakubowiak, Andrzej J, additional, Shaw, Kit L., additional, Daley, Heather, additional, Nikiforow, Sarah, additional, Griffin, Faith Mmanywa, additional, Cornwell, Christine, additional, Shen, Angela, additional, Heery, Christopher, additional, and Maus, Marcela V, additional

Published
2022
Full Text
View/download PDF

47. Allogeneic CAR-T PBCAR0191 with Intensified Lymphodepletion Is Highly Active in Patients with Relapsed/Refractory B-Cell Malignancies

Author

Shah, Bijal D., primary, Jacobson, Caron, additional, Solomon, Scott R., additional, Jain, Nitin, additional, Johnson, Mark C., additional, Vainorius, Monika, additional, Yu, Lou, additional, Heery, Christopher R., additional, List, Alan F., additional, He, Fiona, additional, Reshef, Ran, additional, Akard, Luke P., additional, Sauter, Craig S., additional, Olszewski, Adam J., additional, Deol, Abhinav, additional, and van Besien, Koen, additional

Published
2021
Full Text
View/download PDF

48. Preliminary Safety and Efficacy of PBCAR0191, an Allogeneic 'Off-the-Shelf' CD19-Directed CAR-T for Patients with Relapsed/Refractory (R/R) CD19+ B-ALL

Author

Jain, Nitin, primary, Kantarjian, Hagop, additional, Solomon, Scott R., additional, He, Fiona, additional, Sauter, Craig S., additional, Heery, Christopher R., additional, List, Alan F., additional, Johnson, Mark C., additional, Lou, Yu, additional, Vainorius, Monika, additional, van Besien, Koen, additional, Olszewski, Adam J., additional, Stein, Anthony S., additional, and Shah, Bijal D., additional

Published
2021
Full Text
View/download PDF

49. Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer

Author

DeMaria, Peter J, primary, Lee-Wisdom, Katherine, additional, Donahue, Renee N, additional, Madan, Ravi A, additional, Karzai, Fatima, additional, Schwab, Angie, additional, Palena, Claudia, additional, Jochems, Caroline, additional, Floudas, Charalampos, additional, Strauss, Julius, additional, Marté, Jennifer L, additional, Redman, Jason Mark, additional, Dombi, Eva, additional, Widemann, Brigitte, additional, Korchin, Borys, additional, Adams, Tatiana, additional, Pico-Navarro, Cesar, additional, Heery, Christopher, additional, Schlom, Jeffrey, additional, Gulley, James L, additional, and Bilusic, Marijo, additional

Published
2021
Full Text
View/download PDF

50. Docetaxel Alone or in Combination With a Therapeutic Cancer Vaccine (PANVAC) in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial

Author

Heery, Christopher R., Ibrahim, Nuhad K., Arlen, Philip M., Mohebtash, Mahsa, Murray, James L., Koenig, Kimberly, Madan, Ravi A., McMahon, Sheri, Marté, Jennifer L., Steinberg, Seth M., Donahue, Renee N., Grenga, Italia, Jochems, Caroline, Farsaci, Benedetto, Folio, Les R., Schlom, Jeffrey, and Gulley, James L.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results