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This study investigates how the discrete emotions expressed by travel influencers on YouTube influence viewer engagement, distinguishing between macro- and micro- influencers. Using text mining and machine learning techniques, 6,061 travel-related videos were analyzed. The results indicate that high-arousal negative emotions such as anger and disgust enhance engagement for macro-influencers but reduce engagement for micro- influencers. Conversely, low-arousal negative emotions, such as fear and sadness, increase engagement levels for micro-influencers, while decreasing them for macro-influencers. Positive emotions enhance engagement, particularly among micro-influencers. These insights can inform emotional strategies in influencer marketing.

Background/Aims To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM. Methods This cohort study included patients who were registered as having TB in the National Tuberculosis Surveillance System. The medical and death records of matched patients were obtained from the National Health Information Database and Statistics Korea, respectively, and data from 2011 to 2017 were collected retrospectively. We classified patients according to metformin use among participants who used diabetes drugs for more than 28 days. The primary outcome was all-cause mortality during TB treatment. Double propensity score adjustment was applied to reduce the effects of confounding and multivariable Cox proportional hazard models were used to estimate adjusted hazard ratio (aHR) with 95% confidence interval (CI). Results The all-cause mortality rate during TB treatment was lower (9.5% vs. 12.4%, p < 0.01) in the metformin user group. The hazard of death due to all causes after double propensity score adjustment was also lower in the metformin user group (aHR 0.76, 95% CI 0.67–0.86, p < 0.01). There was no significant difference in mortality between metformin users and non-users for TB-related deaths (p = 0.22); however, there was a significant difference in the non-TB-related deaths (p < 0.01). Conclusions Metformin use in patients with TB–DM co-prevalence is associated with reduced all-cause mortality, suggesting the potential for metformin adjuvant therapy in these patients.

Objectives. This study aimed to compare the oncological outcomes of partial versus superficial or total parotidectomy for superficial T1 or T2 primary parotid cancers and investigate their prognostic factors and recurrence patterns. Methods. The medical records of 77 patients with T1–2 primary parotid malignancies between May 2003 and March 2022 were retrospectively reviewed. Univariate and multivariate analyses were performed to evaluate the prognostic factors associated with overall survival, disease-free survival, and local and distant recurrence. Results. The average follow-up duration was 70.2 months (range, 12–202 months). The 5-year overall and disease-free survival rates were 88.7% and 77.1%, respectively. Twenty-two patients underwent partial parotidectomy, and 55 underwent superficial or total parotidectomy. There were no significant differences in the disease recurrence (P=0.320) and mortality rates (P=0.884) of the partial and superficial or total parotidectomy groups. The mean duration of surgery was shorter and the overall complication rates were significantly lower in the partial group than in the superficial or total parotidectomy group (P=0.049). Sixteen cases of recurrence occurred during the study period (20.8%). Univariate analyses showed that high-grade tumors (P=0.006), lymphovascular invasion (P=0.046), and regional lymph node metastasis (P=0.010) were significant risk factors for disease recurrence. Multivariate analysis identified regional lymph node metastasis as an independent prognostic factor for disease recurrence (P=0.027), and lymphovascular invasion as an independent prognostic factor for overall survival (P=0.033). Conclusion. The conservative surgical approach of partial parotidectomy can yield oncological outcomes comparable to those of superficial or total parotidectomy with careful patient selection in T1-2 parotid cancers.

The future of intelligent manufacturing machines involves autonomous selection of process parameters to maximize productivity while maintaining quality within specified constraints. To effectively optimize process parameters, these machines need to adapt to existing uncertainties in the physical system. This paper proposes a novel framework and methodology for feedrate optimization that is based on a physics-informed data-driven digital twin with quantified uncertainty. The servo dynamics are modeled using a digital twin, which incorporates the known uncertainty in the physics-based models and predicts the distribution of contour error using a data-driven model that learns the unknown uncertainty on-the-fly by sensor measurements. Using the quantified uncertainty, the proposed feedrate optimization maximizes productivity while maintaining quality under desired servo error constraints and stringency (i.e., the tolerance for constraint violation under uncertainty) using a model predictive control framework. Experimental results obtained using a 3-axis desktop CNC machine tool and a desktop 3D printer demonstrate significant cycle time reductions of up to 38% and 17% respectively, while staying close to the error tolerances compared to the existing methods.

Objectives: This study aimed to evaluate the current practices and trends of intraoperative facial nerve (FN) monitoring (IOFNM) during parotidectomy. Methods: A questionnaire containing 33 questions collecting information on the usage, indications, settings, techniques, loss of signal (LOS) management, anesthesiologist cooperation, and perception of usefulness of IOFNM was distributed among 348 members of the Korean Society of Head and Neck Surgery (KSHNS) via a dedicated website. Results: The response rate was approximately 25.6%, and 97% of the respondents reported using IOFNM selectively or routinely during parotidectomy. IOFNM usage decreased as the surgeon’s level of experience increased (p = 0.089), from 100% in those with less than 5 years of experience to 75% in those with 20 or more years. Approximately 95% of respondents reported that the initial event threshold for electromyography activity used was 50–149 μV. Moreover, 52.4% of respondents performed neural mapping of the FN before visual identification. Initial management of LOS in visually intact FNs included checking the IOFNM system (75.3%), confirmation of muscle relaxant dosage (75.3%), and facial twitch identification (58.8%). Further management included proceeding with surgery regardless of persistent LOS (81.2%) and steroid administration sometimes or all of the time (72.9%). Overall, 98.8% of respondents found IOFNM beneficial for safe execution of parotidectomy. Conclusions: The majority of KSHNS surgeons used IOFNM during parotidectomy, although the clinical implementation of the procedure and LOS management varied between practitioners. This could be attributed to the lack of standardized protocols for IOFNM, emphasizing the need for the development of evidence-based consensus guidelines for all institutions.

Abstract Treatment adherence is an underestimated determinant of treatment success. Poor treatment adherence can also affect the efficacy of clinical trials. A combination of multiple adherence‐monitoring methods is required to ensure robustness. We investigated whether multiple adherence‐monitoring methods, including a novel smartwatch‐based monitoring method, would yield reliable and concordant results. In this open, randomized, decentralized clinical trial, vitamin D‐deficient individuals were randomized to an App − only group (an electronic medication diary) or an App + Watch group (i.e., App and smartwatch‐based monitoring) groups after a week run‐in period. The participants received vitamin D supplements (1000 IU) for 12 weeks (two consecutive periods of 6 weeks) with two pill counts (at the sixth week) and biweekly blood samplings for serum 25(OH) vitamin D concentration. Adherence was assessed and compared between the methods. Sixteen participants were enrolled, of which 13 completed the study. Serum 25(OH) vitamin D levels comparably increased in both groups until the first 7 weeks but trended higher in the App + Watch group in the second period. The number of doses recorded by the pill count and App did not differ significantly between the run‐in and Period 1 (p = 0.5534) but became significantly discrepant in Period 2 (p = 0.0225). In contrast, the concordance for smartwatch‐based monitoring was consistent in either period (p = 0.5898 and p = 0.5839, respectively). We explored multiple adherence‐monitoring methods in this pilot feasibility clinical study. Smartwatch‐based adherence monitoring may be an objective and sensitive method for measuring treatment adherence.

Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases. Whole exome sequencing of patients who experienced severe influenza reveals several genes, including scaffold protein AHNAK, with predicted loss-of-function variants that are also identified in our proteomic analyses. Of our identified host factors, 54 significantly alter IAV infection upon siRNA knockdown, and two factors, AHNAK and coatomer subunit COPB1, are also essential for productive infection by SARS-CoV-2. Finally, 16 compounds targeting our identified host factors suppress IAV replication, with two targeting CDK2 and FLT3 showing pan-antiviral activity across influenza and coronavirus families. This study provides a comprehensive network model of IAV infection in human cells, identifying functional host targets for pan-viral HDT.

Porous silicon dioxide (SiO2)/poly(vinylidene fluoride) (PVdF), SiO2/PVdF, and fibrous composite membranes were prepared by electrospinning a blend solution of a SiO2 sol–gel/PVdF. The nanofibers of the SiO2/PVdF (3/7 wt. ratio) blend comprised skin and nanofibrillar structures which were obtained from the SiO2 component. The thickness of the SiO2 skin layer comprising a thin skin layer could be readily tuned depending on the weight proportions of SiO2 and PVdF. The composite membrane exhibited a low thermal shrinkage of ~3% for 2 h at 200 °C. In the prototype cell comprising the composite membrane, the alternating current impedance increased rapidly at ~225 °C, and the open-circuit voltage steeply decreased at ~170 °C, almost becoming 0 V at ~180 °C. After being exposed at temperatures of >270 °C, its three-dimensional network structure was maintained without the closure of the pore structure by a melt-down of the membrane.

Recent studies have reported chronic rhinosinusitis (CRS) as an independent risk factor for stroke. However, the association with stroke depending on the affected sinuses has not been explored. This study aimed to elucidate the side- and sinus-specific relationship between CRS and ischemic stroke through imaging analyses. We retrospectively reviewed the medical records of patients who were diagnosed with ischemic stroke at a tertiary center. CRS was defined as having a total score of greater than or equal to 4, according to the Lund–Mackay scoring system, through brain magnetic resonance imaging or computed tomography. We investigated the side- and sinus-specific correlation between CRS and ischemic stroke. Subgroup analyses were performed for different age groups. CRS prevalence in patients with ischemic stroke was 18.4%, which was higher than the previously reported prevalence in the general population. Overall, there was no correlation between the directions of the CRS and ischemic stroke (p > 0.05). When each sinus was analyzed, the frontal (Cramer’s V = 0.479, p < 0.001), anterior (Cramer’s V = 0.396, p < 0.001)/posterior (Cramer’s V = 0.300, p = 0.008) ethmoid, and sphenoid (Cramer’s V = 0.383, p = 0.005) sinuses showed a statistically significant correlation with the side of stroke, but the maxillary sinus (Cramer’s V = 0.138, p = 0.208) did not. In subgroup analyses, a significant right-side correlation between the two diseases was observed in the older-age subgroup (≥65 years old, Cramer’s V = 0.142, p = 0.040). Diabetes mellitus (odds ratio = 1.596, 95% confidence interval = 1.204–2.116) was identified as an independent risk factor for having CRS in patients with ischemic stroke. CRS of the frontal, anterior/posterior ethmoid, and sphenoid sinuses has a directional relationship with ischemic stroke. Our results on which sinuses correlate with stroke advocate for the active surveillance of CRS in patients at high risk of ischemic stroke.

Introduction This study examined the various factors in the selection of JUUL (and/ or), a pod-mod type electronic cigarette (EC), and the changes in EC patterns before and after the JUUL debut on 24 May 2019, using follow-up survey data of adult tobacco users in South Korea. Methods This study examined transition outcomes among tobacco users and factors associated with future JUUL use. Convenience sample data were collected from adult tobacco users in South Korea, from March–April 2019 (baseline, n=2173) to September 2019 (follow-up, n=779). Results were obtained from the 779 respondents in the follow-up survey, and user data of one or more tobacco products were analyzed. The changes in the proportion of EC and JUUL use during this period were calculated, and multivariate logistic regression analysis was conducted to investigate the selection factors of JUUL. Results Four months after the JUUL launch, the proportion of current EC and JUUL users among the whole sample increased by 10.3% (42.6–52.9%, p

The trifluoromethyl anion rapidly decomposes into difluorocarbene (:CF2) and fluorine ion, limiting its applicability in synthesis. Here, the authors report a strategy to generate and use the short-lived CF3- intermediate from stable CF3H gas via fast biphasic mixing in precisely customized flow dissolvers.

The oxide passivation layer on the lithium metal surface causes uneven deposition and stripping in lithium metal batteries. Here authors introduce uniform homo-epitaxial lithium deposition on the metal surface to alleviate this issue and improve the cycle stability of the lithium metal batteries.

The present study investigated the applicability of a calving prediction model based on supervised machine learning of ruminal temperature (RT) data in dairy cows. The existence of cow subgroups for prepartum RT changes was also examined, and the predictive performance of the model was compared among these subgroups. RT data were collected from 24 Holstein cows at 10 min intervals using an RT sensor system. The average hourly RT was calculated and data were expressed as residual RTs (rRT = actual RT − mean RT for the same time on the previous three days). The mean rRT decreased beginning at approximately 48 h before calving to a low of −0.5°C at 5 h before calving. However, two cow subgroups were identified: cows with a late and small rRT decrease (Cluster 1, n = 9) and those with an early and large rRT decrease (Cluster 2, n = 15). A calving prediction model was developed using five features extracted from the sensor data (indicative of prepartum rRT changes) through a support vector machine. Cross-validation showed that calving within 24 h was predicted with a sensitivity of 87.5% (21/24) and precision of 77.8% (21/27). A significant difference in sensitivity was observed between Clusters 1 and 2 (66.7 vs. 100%, respectively), while none was observed for precision. Therefore, the model based on RT data with supervised machine learning has the potential to efficiently predict calving, although improvements for specific cow subgroups are required.

Abstract Background The Western Pacific Region has one of the fastest-growing populations of older adults (≥ 65 years) globally, among whom tuberculosis (TB) poses a particular concern. This study reports country case studies from China, Japan, the Republic of Korea, and Singapore reflecting on their experiences in managing TB among older adults. Findings Across all four countries, TB case notification and incidence rates were highest among older adults, but clinical and public health guidance focused on this population was limited. Individual country reports illustrated a range of practices and challenges. Passive case finding remains the norm, with limited active case finding (ACF) programs implemented in China, Japan, and the Republic of Korea. Different approaches have been trialled to assist older adults in securing an early diagnosis, as well as adhering to their TB treatment. All countries emphasised the need for person-centred approaches that include the creative application of new technology and tailored incentive programs, as well as reconceptualisation of how we provide treatment support. The use of traditional medicines was found to be culturally entrenched among older adults, with a need for careful consideration of their complementary use. TB infection testing and the provision of TB preventive treatment (TPT) were underutilised with highly variable practice. Conclusion Older adults require specific consideration in TB response policies, given the burgeoning aging population and their high TB risk. Policymakers, TB programs and funders must invest in and develop locally contextualised practice guidelines to inform evidence-based TB prevention and care practices for older adults.

Our study aimed to identify potential biocontrol agents (BCAs) against major phytopathogens under in vitro conditions by screening the Freshwater Bioresources Culture Collection (FBCC), Korea. Of the identified 856 strains, only 65 exhibited antagonistic activity, among which only one representative isolation, Brevibacillus halotolerans B-4359 was selected based on its in vitro antagonistic activity and enzyme production. Cell-free culture filtrate (CF) and volatile organic compounds (VOCs) of B-4359 were shown to be effective against the mycelial growth of Colletotrichum acutatum. Notably, B-4359 was found to promote spore germination in C. acutatum instead of exhibiting a suppressive effect when the bacterial suspension was mixed with the spore suspension of C. acutatum. However, B-4359 showed an excellent biological control effect on the anthracnose of red pepper fruits. Compared to other treatments and untreated control, B-4359 played a more effective role in controlling anthracnose disease under field conditions. The strain was identified as B. halotolerans using BIOLOG and 16S rDNA sequencing analyses. The genetic mechanism underlying the biocontrol traits of B-4359 was characterized using the whole-genome sequence of B-4359, which was closely compared with related strains. The whole-genome sequence of B-4359 consisted of 5,761,776 bp with a GC content of 41.0%, including 5,118 coding sequences, 117 tRNA, and 36 rRNA genes. The genomic analysis identified 23 putative secondary metabolite biosynthetic gene clusters. Our results provide a deep understanding of B-4359 as an effective biocontrol agent against red pepper anthracnose for sustainable agriculture.

This paper proposes a practical framework for developing a net-zero electricity mix scenario (NEMS), which considers detailed conditions for supply of each energy. NEMS means a path scenario for power generation amount by year of each generation resource required to achieve carbon neutrality in 2050. NEMS framework refers to a methodological framework that contains procedures and requirements to continuously update the NEMS by comprehensively reflecting policy changes. For evaluation of NEMS, indicators such as a system inertia resource ratio (SIRR) and a fuel conversion rate (FCR) are proposed. The proposed framework and indicators are applied for the 2050 NEMS in Korea’s electricity sector. The SIRR, indicating the ratio of inertial resources to total resources, projects values of 49% and 15% for the years 2030 and 2050, respectively. Furthermore, the FCR, reflecting the ratio of fuel conversion for resources undergoing this process, predicts that all targeted resources will have completed conversion by the year 2043.

Post-thyroidectomy syndrome (PTS), characterized by voice issues after thyroidectomy without recurrent laryngeal nerve injury, was investigated in this study. The Voice Fatigue Index (VFI) and cepstral analysis were employed for subjective and objective voice evaluation. Retrospective analysis involved 96 patients (37 males, 59 females) who underwent thyroidectomy without nerve injury from April 2018 to June 2022. Assessments pre- and post-thyroidectomy included the Voice Handicap Index (VHI) and VFI, along with auditory perceptual, acoustic (including cepstral), aerodynamic, and glottal vibration analyses. In females, although the GRBAS scale showed no significant change, both VHI and VFI increased post-thyroidectomy. Significant correlations were observed between the VHI and VFI in females. Acoustic analysis indicated a decrease in the cepstral peak prominence (CPP) of vowels (/a/) and sentences in females, with significant correlations between changes in the CPP/a/ and VHI/VFI. The maximum fundamental frequency (F0max) exhibited a significant decrease, correlating with the VHI and VFI changes. The VFI demonstrated effectiveness in subjective PTS voice evaluation, comparable to the VHI. The present study highlights the potential of cepstral analysis as an index reflecting subjective voice discomfort, suggesting its promise for a comprehensive PTS voice evaluation.

The current study aimed to investigate the association between asthma and periodontitis in the Korean adult population. Data from the Korean Genome and Epidemiology Study Health Examinees between 2004 and 2016 were considered. Of the 173,209 participants, 2521 asthmatic and 132,806 control participants were selected. The participants were categorized according to their current status of asthma, as ‘well-controlled’, ‘being treated’, and ‘not being treated’. The prevalence of periodontitis was found to be significantly higher in the participants with asthma (13.1%) than in the controls (7.3%). In the fully adjusted model, the patients with asthma had a higher odds ratio (OR = 1.79, 95% confidence interval [CI] = 1.59–2.02, p < 0.001) for periodontitis than those without asthma. The results were consistent across all the age and sex subgroups. The adjusted ORs for periodontitis were 2.15 (95% CI = 1.68–2.76, p < 0.001) in the ‘well-controlled’ asthma group, 1.44 (95% CI = 1.16–1.78, p < 0.001) in the ‘being treated’ asthma group, and 1.86 (95% CI = 1.55–2.22, p < 0.001) in the ’not being treated’ asthma group compared to the control group. Overall, we found asthma to be associated with periodontitis in Korean adults, and the participants with well-controlled asthma had the highest ORs for periodontitis.

Abstract Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignancy that transforms from PA. Early detection of the carcinoma by biopsy is difficult due to similar histopathology of the malignant and benign components. To address this, we investigated and compared the characteristic miRNA expression patterns across samples of the PA, carcinomatous portions (CA) of CXPA, as well as conventional PA. We selected 13 CXPA and 16 conventional PA FFPE samples, separated the PA and CA portions of CXPA samples and conducted miRNA profiling for each group. Among 13 transcripts that were differentially expressed between PA and CA of CXPA, eight miRNAs were up-regulated and five down-regulated in CA. Bioinformatic analysis revealed that the up-regulated miRNAs were related to cancer progression and down-regulated ones to tumor suppression. Additionally, seven miRNAs were significantly up-regulated in PA of CXPA compared to conventional PA, although they are histopathologically similar. Almost all of these transcripts interacted with TP53, a well-known tumor suppressor. In conclusion, we identified differentially expressed miRNAs in PA and CA of CXPA, which were closely associated with TP53 and various cancer-related pathways. We also identified differentially expressed miRNAs in the PA of CXPA and conventional PA which may serve as potential biomarkers.

The characteristics of 3-dimensional (3D) cultured periodontal ligament stem cells derived from permanent teeth (pPDLSCs) and supernumerary teeth (sPDLSCs) were compared and evaluated in this study. pPDLSCs and sPDLSCs were cultured in an ultra-low attachment 6-well plate, and the changes in morphology and size were observed under an optical microscope for 14 days. Cell counting kit-8 was used to quantitatively evaluate cell viability, and a live/dead assay was performed for the qualitative assessment. The degrees of osteogenic, chondrogenic, and adipogenic differentiation of pPDLSCs and sPDLSCs were also assessed. The pPDLSCs and sPDLSCs were initially spherical, and sPDLSCs were smaller than pPDLSCs. The viability of pPDLSCs decreased by 47.9% (day 3) and 10.4% (day 7), whereas that of sPDLSCs decreased by 34.3% (day 3) and 2.5% (day 7) compared to the percentage on Day 1. No significant difference in osteogenic differentiation was found (p = 0.94); however, significant differences in adipocyte and cartilage differentiation were observed (p = 0.003 and p = 0.013, respectively). Within the limitations of this study, sPDLSCs and pPDLSCs exhibited multilineage differentiation capacities, including osteogenic, chondrogenic, and adipogenic differentiation, in 3D culture. Overall, pPDLSCs should be further investigated as a source of stem cells for tissue engineering and regenerative medicine.

The UAE's environment is characterized by low rainfall, high temperatures, poor soil and lack of natural waterways. The country has been making tremendous efforts to build a sustainable agricultural and animal wealth sector that is better able to contribute to its national agenda of food security. Commercial cattle farming in such challenging conditions would require an effective disease prediction and warning system for optimizing the production dynamics. Therefore, we are proposing the use of smart livestock system comprising of orally ingested bio-capsules for monitoring the livestock health, connected through a customized long-range network (430 MHz) in the United Arab Emirates, which monitors the real time animal body condition data (temperature and body activity) using a mobile or web-based application. The study demonstrated a 100% success rate in estrus alarms in the test animals, 61.29% for calving alerts and an accurate disease prediction warning in all the animals diagnosed unhealthy. the conception rate in these estrus diagnosed animals with artificial insemination was 61.53%, which was significantly higher than the conception rate in the absence of this detection technology at the farm. The capsule was well tolerated in all the test animals and did not show any acute adverse or allergic reactions. This is the first of its kind of study using these advanced bio-capsules and development of the customized long-range network in the United Arab Emirates for smart livestock healthcare management.

Early detection, diagnosis and treatment of cattle disease is very important for any livestock farming enterprise, to remain viable. Improved cattle health and productivity through advanced and innovative smart farming technologies will pave the way for the United Arab Emirates in achieving its national agenda of food security. Advanced livestock health care bio-capsules were administered through mouth into the rumen of cattle in a private dairy farm to a group of cattle to monitor their health. The effect of using such biosensors on the animal health was not previously described by any other researchers. Hence, in the current study, we tried to understand the effects of the bio-capsules on the cattle health, if any. This was done through collecting and screening blood samples from the test animals for different hemato-biochemical parameters and our results showed that there were no harmful effects of using such bio-capsules for livestock health monitoring.

Abstract Lithium–sulfur batteries (LSBs) have emerged as promising power sources for high‐performance devices such as electric vehicles. However, the poor energy density of LSBs owing to polysulfide shuttling and passivation has limited their further market penetration. To mitigate this challenge, two‐dimensional (2D) siloxene (2DSi), a Si‐based analog of graphene, is utilized as an additive for sulfur cathodes. The 2DSi is fabricated on a large scale by simple solvent extraction of calcium disilicide to form a thin‐layered structure of Si planes functionalized with vertically aligned hydroxyl groups in the 2DSi. The stoichiometric reaction of 2DSi with polysulfides generates a thiosulfate redox mediator, secures the intercalation pathway, and reveals Lewis acidic sites within the siloxene galleries. The 2DSi utilizes the corresponding in‐situ‐formed electrocatalyst, the 2D confinement effect of the layered structure, and the surface affinity based on Lewis acid–base interaction to improve the energy density of 2DSi‐based LSB cells. Combined with the commercial carbon‐based current collector, 2DSi‐based LSB cells achieve a volumetric energy density of 612 Wh Lcell−1 at 1 mA cm−2 with minor degradation of 0.17% per cycle, which rivals those of state‐of‐the‐art LSBs. This study presents a method for the industrial production of high‐energy‐dense LSBs.

Based on the metaphorical association of color, the color red is often associated with a “hot deal” in a price promotion context, which has led to the popular use of red in promotions in the marketplace. In two studies, this research challenges the lay belief that the color red used in price advertising positively influences consumers’ perceptions of value. The findings from the two studies revealed a contrasting pattern of results depending on the depth of the discount. When the discount depth was high (consistent with consumers’ lay belief), the red color led to more favorable responses to a price promotion than other colors (white or blue in Study 1 and green in Study 2). In contrast, when the discount depth was unambiguously low, consumers who were exposed to a red colored price promotion advertisement reported a perception of a lower value compared to those who saw the same advertisement with other colors We attribute this effect to the degree of “processing fluency” that arises from the congruence between the color and promotion content. Our research adds to the existing psychology literature on color functioning by showing a match between the referential meaning of the color red (i.e., a hot deal) and consumers’ perceptions in marketing communication.

Neck necrotic lymph nodes commonly correspond to metastasis or benign inflammatory conditions such as Kikuchi disease and tuberculosis. Ultrasound-guided biopsy can be used for differential diagnosis, but results may be unclear. Therefore, this study aimed to identify target microRNAs (miRNAs) and genes for the differential diagnosis of inflammatory and malignant necrotic lymph nodes. We selected six inflammatory lymphadenitis formalin-fixed paraffin-embedded (FFPE) samples that showed internal necrosis and five cancer necrotic FFPE samples. Tissue microarray (TMA) was performed to separate the necrotic and cancerous portions. Total RNA was extracted from six pairs of separated inflammatory necrosis, five pairs of cancer necrosis, and cancer portions. Differentially expressed miRNAs were analyzed by comparing inflammatory necrosis, cancer, and cancer necrosis. Seventeen miRNAs were upregulated in cancer necrosis compared to inflammatory necrosis, and two miRNAs (hsa-miR-155-5p and hsa-miR-146b-5p) showed lower expression in cancer necrotic cells. Nineteen miRNAs that were differentially expressed between inflammatory and cancer necrosis were analyzed for target gene expression; these transcripts demonstrated a clear relationship with cancer. The differentially expressed miRNAs in inflammatory and tumor necrosis were associated with cancer-related pathways. These preliminary results might help in the differential diagnosis of cervical metastatic necrotic lymphadenopathy and avoiding unnecessary excisional biopsies.

Abstract The development of sulfur cathodes with high areal capacity and high energy density is crucial for the practical application of lithium–sulfur batteries (LSBs). LSBs can be built by employing (ultra) high‐loading sulfur cathodes, which have rarely been realized due to massive passivation and shuttling. Herein, microspheres of a carbon–carbon nitride composite (C@CN) with large mesopores are fabricated via molecular cooperative assembly. Using the C@CN‐based electrodes, the effects of the large mesopores and N‐functional groups on the electrochemical behavior of sulfur in LSB cells are thoroughly investigated under ultrahigh sulfur‐loading conditions (>15 mgS cm−2). Furthermore, for high‐energy‐density LSBs, the C@CN powders are pelletized into a thick free‐standing electrode (thickness: 500 μm; diameter: 11 mm) via a simple briquette process; here, the total amount of energy stored by the LSB cells is 39 mWh, corresponding to a volumetric energy density of 440 Wh L−1 with an areal capacity of 24.9 and 17.5 mAh cm−2 at 0.47 and 4.7 mA cm−2, respectively (at 24 mgS cm−2). These results have significantly surpassed most recent records due to the synergy among the large mesopores, (poly)sulfide‐philic surfaces, and thick electrodes. The developed strategy with its potential for scale‐up successfully fills the gap between laboratory‐scale cells and practical cells without sacrificing the high areal capacity and high energy density, providing a solid foundation for the development of practical LSBs.

Fiber media filtration for combined sewer overflow (CSO) treatment was evaluated in this work. Pilot-scale experiments of CSO treatment involve seven layers that form radial-type fiber media filters. The fiber media filter was characterized using analysis techniques and exhibited extremely high hydrophobicity and negative charge. The results obtained for a sewer treatment plant at Tancheon in Seoul revealed potential for suspended solid, total organic carbon, and biochemical oxygen demand removal with efficiencies of 89.6%, 56%, and 42%, respectively. The results are consistent with the sieving effects and electrostatic repulsion between fiber media and pollutants. Head loss was induced by organic pollutants and was 10.5 cm after 20 h of operation. To mitigate the head loss induced by organic pollutants on the fiber media filter, sodium hypochlorite (NaClO) was used as a chemical backwashing agent. An NaClO concentration of 2000 mg/L with a soaking time of 24 h yielded an optimal head loss recovery of 96.2% of the initial head loss obtained for the virgin fiber media filter without media filter degradation. The result of the present study will provide practical insight and act as a technical guide for CSO treatment plant engineers.

This paper proposes a mathematical model of an electric arc furnace (EAF) system based on the voltage and current (V–I) field data. The proposed method is formulated using the ellipse equation, which is derived from the measurement profile of real EAF systems. This paper also presents the harmonics and power-pattern information corresponding to the smelting processes (boring, melting, and refining) in order to realistically design an EAF for potential industrial applications. The third harmonic component significantly affects the shape of the V–I curve in realistic EAF systems, while the periodic power fluctuation is closely associated with the size of the ellipse. These characteristics can be formulated and designed by the proposed method, and even in the absence of the V–I profile, an EAF model can be generated using the generalized information provided in this paper. The electrical phenomenon in the proposed method is mathematically verified using the PSCAD/EMTDC software.

The Korean Society of Laryngology, Phoniatrics and Logopedics appointed a task force to establish clinical practice guidelines for the management of unilateral vocal fold paralysis (UVFP). These guidelines cover a comprehensive range of management-related factors, including the diagnosis and treatment of UVFP, and provide in-depth information based on current, up-to-date knowledge. Detailed evidence profiles are provided for each recommendation. The CORE databases, including OVID Medline, Embase, the Cochrane Library, and KoreaMed, were searched to identify all relevant papers, using a predefined search strategy. When insufficient evidence existed, expert opinions and Delphi questionnaires were used to fill the evidence gap. The committee developed 16 evidence-based recommendations in six categories: initial evaluation (R1–4), spontaneous recovery (R5), medical treatment (R6), surgical treatment (R7–14), voice therapy (R15), and aspiration prevention (R16). The goal of these guidelines is to assist general otolaryngologists and speech-language pathologists who are primarily responsible for treating patients with UVFP. These guidelines are also intended to facilitate understanding of the condition among other health-care providers, including primary care physicians, nurses, and policy-makers.

This paper intends to understand the overseas business expansion of a Japanese SME that is facilitated by strategic management of technical interns (TIs), a type of foreign migrant labor in Japan. We challenge the current prejudices and narrow view on the role of TIs by introducing a unique case wherein a rural SME utilized TIs as strategic human resources. Furthermore, we highlighted the positive influence of TIs on the gradual insiderization in foreign markets and development of new business opportunities.

Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

This article presents a control strategy for a modular multilevel converter (MMC) to prevent commutation failure of a line-commutated converter (LCC), forming a three-terminal hybrid HVDC transmission system, where one LCC sending end is connected to the large generation and two receiving ends (LCC inverter and MMC) are located near the load center. This configuration, one of the potential options, has been proposed to strengthen Korea electric power transmission system through the optimized use of existing assets and rights-of-way, extremely challenging to secure. The MMC power control strategy has been developed to regulate the AC voltage and the extinction angle of the LCC inverter. This indirect yet effective active and reactive power control of the LCC inverter terminal helps prevent the commutation failure (CF) of the LCC in emergency and maximize the benefits of the costly planning option. By establishing a theoretical foundation for this power control problem and relationship among the control parameters, we quantify the active power reference for MMC to secure the desired LCC extinction angle. A coordinated strategy has been developed for the AC filter, the on-load tap changer of a transformer, along with the MMC control to lower the risk of CF and its catastrophic impact on the whole power system. The validity and performance of the proposed control methods are demonstrated for the real Korea electric power planning cases using a real-time power system simulator.

Summary: The tetravalent dengue vaccine candidate, TAK-003, induces a functional antibody response, but the titers of antibodies against the four serotypes of the dengue virus (DENV) can vary. Here, through a transcriptomic analysis on whole blood collected from recipients of a two-dose schedule of TAK-003, we examine gene expression, splicing, and transcript isoform-level changes for both protein-coding and noncoding genes to broaden our understanding of the immune response. Our analysis reveals a dynamic pattern of vaccine-associated regulation of long noncoding RNAs (lncRNAs), differential splicing of interferon-stimulated gene exons, and gene expression changes related to multiple signaling pathways that detect viral infection. Co-expression networks isolate immune cell-type-related and interferon-response modules that represent specific biological processes that correlate with more robust antibody responses. These data provide insights into the early determinants of the variable immune response to the vaccine, highlighting the significance of splicing and isoform-level gene regulatory mechanisms in defining vaccine immunogenicity.

Continuous and non-invasive measurement of intracranial pressure (ICP) in traumatic brain injury (TBI) is important to recognize increased ICP (IICP), which can reduce treatment delays. The purpose of this study was to develop an electroencephalogram (EEG)-based prediction model for IICP in a porcine TBI model. Thirty swine were anaesthetized and underwent IICP by inflating a Foley catheter in the intracranial space. Single-channel EEG data were collected every 6 min in 10 mmHg increments in the ICP from baseline to 50 mmHg. We developed EEG-based models to predict the IICP (equal or over 25 mmHg) using four algorithms: logistic regression (LR), naive Bayes (NB), support vector machine (SVM), and random forest (RF). We assessed the performance of each model based on the accuracy, sensitivity, specificity, and AUC values. The accuracy of each prediction model for IICP was 0.773 for SVM, 0.749 for NB, 0.746 for RF, and 0.706 for LR. The AUC of each model was 0.860 for SVM, 0.824 for NB, 0.802 for RF, and 0.748 for LR. We developed a machine learning prediction model for IICP using single-channel EEG signals in a swine TBI experimental model. The SVM model showed good predictive power with the highest AUC value.

The Brucella species is the causative agent of brucellosis in humans and animals. So far, brucellosis has caused considerable economic losses and serious public health threats. Furthermore, Brucella is classified as a category B bioterrorism agent. Although the mortality of brucellosis is low, the pathogens are persistent in mammalian hosts and result in chronic infection. Brucella is a facultative intracellular bacterium; hence, it has to invade different professional and non-professional phagocytes through the host phagocytosis mechanism to establish its lifecycle. The phagocytosis of Brucella into the host cells undergoes several phases including Brucella detection, formation of Brucella-containing vacuoles, and Brucella survival via intracellular growth or being killed by host-specific bactericidal activities. Different host surface receptors contribute effectively to recognize Brucella including non-opsonic receptors (toll-like receptors and scavenger receptor A) or opsonic receptors (Fc receptors and complement system receptors). Brucella lacks classical virulence factors such as exotoxin, spores, cytolysins, exoenzymes, virulence plasmid, and capsules. However, once internalized, Brucella expresses various virulence factors to avoid phagolysosome fusion, bypass harsh environments, and establish a replicative niche. This review provides general and updated information regarding Brucella phagocytosis mediated by pathogen-host interactions and their intracellular survival in host cells.

This study involved conducting a survival analysis by fitting a Cox proportional hazards model to Korea Labor Panel data to analyze the impact of parental job loss on children’s delayed admission to colleges and universities in South Korea, using 376 subjects whose parental education levels were college-level or higher. Since Korea Labor Panel data are interval- and right-censored, we compared three imputation methods: simple omission, imputation as the average of the left and right values of the interval, and multiple imputation. Their integrated areas under the ROC curve (AUC) and mean square errors (MSE) were compared to assess their predictive and estimation performances. It was found that, within the simulation, the multiple imputation method exhibited a lower MSE than the other two methods. However, no difference was observed in the iAUC values. In the group where each householder had at least a college degree, parental job loss was significantly related to the delayed college or university admission of the first-born child regardless of the use of the interval censoring imputation method. In particular, when the first-born children experienced their parents’ unemployment at the age of 18, the probability of college admission was reduced nearly by 53% compared to cases where they did not. This analysis implies that the government should develop a policy in the education system offering psychosocial support for adolescents who cannot expect parental help.

Aqueous zinc batteries are promising candidates for large scale energy storage systems but development of the cathode material remains a challenge. Here, the authors show a conductive 2D metal-organic framework involving intercalation pseudocapacitance mechanism for enhanced rate capability.

Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to provide guidance on the implementation of a surgical treatment of oral cancer. MEDLINE databases were searched for articles on subjects related to “surgical management of oral cancer” published in English. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. The quality of evidence was rated with use RoBANS (Risk of Bias Assessment Tool for Nonrandomized Studies) and AMSTAR (A Measurement Tool to Assess the Methodological Quality of Systematic Reviews). Evidence-based recommendations for practice were ranked according to the American College of Physicians grading system. Additional directives are provided as expert opinions and Delphi questionnaire when insufficient evidence existed. The Committee developed 68 evidence-based recommendations in 34 categories intended to assist clinicians and patients and counselors, and health policy-makers. Proper surgical treatment selection for oral cancer, which is directed by patient- and subsite-specific factors, remains the greatest predictor of successful treatment outcomes. These guidelines are intended for use in conjunction with the individual patient’s treatment goals.

This paper presents a grid frequency responsive inertial control for the modular multilevel converter-high voltage DC (MMC-HVDC) using the MMC design attribute, i.e. submodule redundancy for high reliability. This control does not rely on the external energy sources in providing the inertial response. With an increase in the number of levels of MMCs via the proposed nlevel control, the submodule capacitor voltage decreases, and the electrostatic energy then flows from the submodule capacitors and supports extra power to the grid in need. Decoupled control of the AC, DC and submodule dynamics of the MMC maintains the desired control performance during and after the inertial response, emulating the inherent behavior of the synchronous machine. This study further quantifies the inertia constant of the MMC, equivalent to that of the synchronous machine. The proposed control performance is demonstrated in the context of a Jeju Island power grid with MMC-HVDC systems for the offshore wind interconnection and interconnection between mainland and Jeju. Simulation results present that the proposed method improves the frequency response in harmony with existing synchronous generators and line-commuted converter based HVDC system.

This paper proposes the droop control algorithm for multiple distributed Battery Energy Storage Systems (ESS) with their state of charge (SOC) feedback, shown to be effective in providing grid services while managing the SOC of the ESS. By extending the mathematical links between the ESS SOC and power dynamics for frequency regulation, this paper elaborates on how the proposed scheme integrates multiple ESS into the load frequency control and the ESS effectively augments the functional roles of the incumbent generators. The control performance for a group of ESS in grid operations is evaluated and characterized by using metrics such as the cut-off frequency and settling time, and the initial and final value theorems. Theoretical insights and practical issues are discussed. Various numerical examples and case studies for a simplified Australian network with high penetration of renewables demonstrate the validity and efficacy of the proposed method.

Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase and has been found to have protective effects against several bacterial infections. In this study, we investigate the effects of simvastatin treatment on RAW 264.7 macrophage cells and ICR mice against Brucella (B.) abortus infections. The invasion assay revealed that simvastatin inhibited the Brucella invasion into macrophage cells by blocking the mevalonic pathway. The treatment of simvastatin enhanced the trafficking of Toll-like receptor 4 in membrane lipid raft microdomains, accompanied by the increased phosphorylation of its downstream signaling pathways, including JAK2 and MAPKs, upon =Brucella infection. Notably, the suppressive effect of simvastatin treatment on Brucella invasion was not dependent on the reduction of cholesterol synthesis but probably on the decline of farnesyl pyrophosphate and geranylgeranyl pyrophosphate synthesis. In addition to a direct brucellacidal ability, simvastatin administration showed increased cytokine TNF-α and differentiation of CD8+ T cells, accompanied by reduced bacterial survival in spleens of ICR mice. These data suggested the involvement of the mevalonate pathway in the phagocytosis of B. abortus into RAW 264.7 macrophage cells and the regulation of simvastatin on the host immune system against Brucella infections. Therefore, simvastatin is a potential candidate for studying alternative therapy against animal brucellosis.

We investigated the potential probiotic properties of Limosilactobacillus fermentum KGC1601 isolated from Panax ginseng. Ginseng cultivated in an experimental field of the Korea Ginseng Research Institute was fermented, followed by single colony selection from MRS agar. We performed 16s-rRNA sequencing and whole-genome analysis to identify L. fermentum and evaluate the biosafety parameters of this strain, respectively. We confirmed this strain was susceptible to six antibiotics, as proposed by the European Food Safety Authority, did not produce biogenic amines, and did not exhibit any hemolytic activity. Acid resistance and bile salt tolerance, which are essential properties of a probiotic agent, were investigated. Notably, distinguishing properties of this strain were that it exhibited excellent bile salt tolerance and anti-inflammatory effects. The excellent bile salt tolerance was confirmed by scanning electron microscopy. Through qRT-PCR and ELISA studies, it was revealed that L. fermentum KGC1601 pre-treatment up-regulates anti-inflammatory cytokines and down-regulates pro-inflammatory cytokines in RAW 264.7 cells. Consequently, we suggested that L. fermentum KGC1601 can be safely used as a potential anti-inflammatory functional probiotic agent.

ObjectiveThe chest X-ray (CXR) is the most readily available and common imaging modality for the assessment of pneumonia. However, detecting pneumonia from chest radiography is a challenging task, even for experienced radiologists. An artificial intelligence (AI) model might help to diagnose pneumonia from CXR more quickly and accurately. We aim to develop an AI model for pneumonia from CXR images and to evaluate diagnostic performance with external dataset.MethodsTo train the pneumonia model, a total of 157,016 CXR images from the National Institutes of Health (NIH) and the Korean National Tuberculosis Association (KNTA) were used (normal vs. pneumonia = 120,722 vs.36,294). An ensemble model of two neural networks with DenseNet classifies each CXR image into pneumonia or not. To test the accuracy of the models, a separate external dataset of pneumonia CXR images (n = 212) from a tertiary university hospital (Gachon University Gil Medical Center GUGMC, Incheon, South Korea) was used; the diagnosis of pneumonia was based on both the chest CT findings and clinical information, and the performance evaluated using the area under the receiver operating characteristic curve (AUC). Moreover, we tested the change of the AI probability score for pneumonia using the follow-up CXR images (7 days after the diagnosis of pneumonia, n = 100).ResultsWhen the probability scores of the models that have a threshold of 0.5 for pneumonia, two models (models 1 and 4) having different pre-processing parameters on the histogram equalization distribution showed best AUC performances of 0.973 and 0.960, respectively. As expected, the ensemble model of these two models performed better than each of the classification models with 0.983 AUC. Furthermore, the AI probability score change for pneumonia showed a significant difference between improved cases and aggravated cases (Δ = -0.06 ± 0.14 vs. 0.06 ± 0.09, for 85 improved cases and 15 aggravated cases, respectively, P = 0.001) for CXR taken as a 7-day follow-up.ConclusionsThe ensemble model combined two different classification models for pneumonia that performed at 0.983 AUC for an external test dataset from a completely different data source. Furthermore, AI probability scores showed significant changes between cases of different clinical prognosis, which suggest the possibility of increased efficiency and performance of the CXR reading at the diagnosis and follow-up evaluation for pneumonia.

The effects of Cobalt (II) chloride (CoCl2) in the context of Brucella abortus (B. abortus) infection have not been evaluated so far. Firstly, we found that CoCl2 treatment inhibited the phagocytosis of B. abortus into RAW 264.7 cells. The inhibition of bacterial invasion was regulated by F-actin formation and associated with a reduction in the phosphorylation of ERK1/2 and HIF-1α expression. Secondly, the activation of trafficking regulators LAMP1, LAMP2, and lysosomal enzyme GLA at the transcriptional level activated immune responses, weakening the B. abortus growth at 4 h post-infection (pi). The silencing of HIF-1α increased bacterial survival at 24 h pi. At the same time, CoCl2 treatment showed a significant increase in the transcripts of lysosomal enzyme HEXB and cytokine TNF-α and an attenuation of the bacterial survival. Moreover, the enhancement at the protein level of HIF-1α was induced in the CoCl2 treatment at both 4 and 24 h pi. Finally, our results demonstrated that CoCl2 administration induced the production of serum cytokines IFN-γ and IL-6, which is accompanied by dampened Brucella proliferation in the spleen and liver of treated mice, and reduced the splenomegaly and hepatomegaly. Altogether, CoCl2 treatment contributed to host resistance against B. abortus infection with immunomodulatory effects.

The analysis of the electrocardiogram (ECG) is critical for the diagnosis of arrhythmias. Recent advances in information and communications technology (ICT) have led to the development of wearable ECG devices and arrhythmia-detection algorithms. This study aimed to develop an ICT-based clinical trial service platform using a self-reporting technique for real-time arrhythmia detection. To establish a clinical-trial service platform, a mobile application (app), a demilitarized zone (DMZ), an internal network, and Amazon web services virtual private cloud (AWS-VPC) were developed. The ECG data acquired by a wearable device were transmitted to the mobile app, which collected the participants’ self-reported information. The mobile app transmitted raw ECG and self-reported data to the AWS-VPC and DMZ, respectively. In the AWS-VPC, the live-streaming and playback-reviewer services were operational to display the currently and previously acquired ECG data to clinicians through the web client. All the measured data were transmitted to the internal network, in which the arrhythmia-detection algorithm was executed and all the data were saved. The self-reporting technique and arrhythmia-detection algorithm are the key elements of this platform. In particular, subjective information of participants can be easily collected using a self-reporting technique. These features are particularly of critical importance for treating painless, sparsely occurring arrhythmias.

Wearable devices and digital health technologies have enabled the exchange of urgent clinical trial information. We developed an application to improve the functioning of decentralized clinical trials and performed a heuristic evaluation to reflect the user demands of existing clinical trial workers. The waterfall model of the software life cycle was used to guide the development. Focus group interviews (N = 7) were conducted to reflect the needs of clinical research professionals, and Wizard of Oz prototyping was performed to ensure high usability and completeness. Unit tests and heuristic evaluation (N = 11) were used. Thematic analysis was performed using the focus group interview data. Based on this analysis, the main menu was designed to include health management, laboratory test results, medications, concomitant medications, adverse reactions, questionnaires, meals, and My Alarm. Through role-playing, the functions and configuration of the prototype were adjusted and enhanced, and a heuristic evaluation was performed. None of the heuristic evaluation items indicated critical usability errors, suggesting that the revised prototype application can be practically applied to clinical trials. The application is expected to increase the efficiency of clinical trial management, and the development process introduced in this study will be helpful for researchers developing similar applications in the future.

The purpose of this study is to conduct drought vulnerability assessment and cluster analysis of Korean island areas at eup (town) myeon (subcounty) level. Drought vulnerability assessment was conducted using factor analysis and entropy method, and cluster analysis was analyzed using K-means, a nonhierarchical cluster analysis method. Vulnerability consisted of climate exposure, sensitivity, and adaptive capacity. Twenty-two indicators were used to evaluate and analyze vulnerability of drought in small island areas. The results of entropy method showed that winter rainfall, no rainfall days, agricultural population rate, cultivation area rate, water supply rate and groundwater capacity have a substantial impact on drought assessment. The overall assessment of vulnerability indicated that Seodo-myeon Ganghwa-gun, Seolcheon-myeon Namhae-gun, and Samsan-myeon Ganghwa-gun were most vulnerable to drought. The cluster analysis was evaluated by categorizing the regions into three clusters, and policy support and planning are needed to suit the characteristics of each cluster was observed.

This paper proposes a generic analysis framework for a grid supporting modular multilevel converter (MMC)-high voltage DC (HVDC) in a multi-infeed of line commutated converter (LCC) and MMC (MILM) system. MMC-HVDC can support the grid by compensating for the exact reactive power consumptions within the MMC-HVDC system and the varying power system conditions in the MILM system. Maximum active/reactive power capability (MPQC) curve and PQ loading curve comparison process is introduced to properly design a grid supporting MMC-HVDC. While the MPQC curve presents the maximum PQ range of the MMC-HVDC system based on the submodule capacitance value and the modulation index, the PQ loading curve presents the reactive power requirement from the power system that MMC-HVDC needs to compensate. Finally, the comparison of these two curves yields the proper value of submodule capacitance and the modulation index for sufficiently supporting the MILM system. The proposed framework is validated with detailed PSCAD/EMTDC simulation; it demonstrated that it could be applied to various power system conditions.