1. Discontinuation of metformin to prevent metformin-induced high colonic FDG uptake
- Author
-
Eugène van Puijenbroek, Pieter L. Jager, Brian N. Vendel, Hedwig Klarenbeek, Jos G. W. Kosterink, Nanno Schreuder, PharmacoTherapy, -Epidemiology and -Economics, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Targeted Gynaecologic Oncology (TARGON), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
- Subjects
Adult ,Male ,medicine.medical_specialty ,PET/CT ,Colon ,IMPACT ,Drug interaction ,Type 2 diabetes ,Gastroenterology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,F-18-FDG PET ,[F-18]fluorodeoxyglucose ,Aged ,Retrospective Studies ,ACCUMULATION ,[18F]fluorodeoxyglucose ,Fluorodeoxyglucose ,PET-CT ,business.industry ,Biological Transport ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Metformin ,Discontinuation ,DIABETIC-PATIENTS ,PET ,Diabetes Mellitus, Type 2 ,Withholding Treatment ,030220 oncology & carcinogenesis ,Original Article ,Female ,Radiopharmaceuticals ,business ,medicine.drug ,CT - Abstract
Objective In this retrospective, single-center observational study, we investigated whether discontinuing metformin for at least 48 h prevents metformin-induced [18F]fluorodeoxyglucose (FDG) uptake in all segments of the colon. Methods Patients with type 2 diabetes who were using metformin before undergoing an FDG PET/CT scan were included. Two groups were created: patients who discontinued metformin for less than 48 h ( Results Colonic FDG uptake in the ≥ 48 h group (n = 23) was higher than uptake in the control group (n = 96) in the colon descendens [odds ratio (OR) 14.0; 95% confidence interval (CI) 4.8–40.9; p value: 0.001] and rectosigmoid (OR 11.3; 95% CI 4.0–31.9; p value: 0.001), and there was no difference in the colon ascendens and transversum. Colonic FDG uptake in the n = 25) was higher than uptake in the ≥ 48 h group (n = 23) in the colon transversum (OR 4.8; 95% CI 1.3–18.5; p value: 0.022) and rectosigmoid (p value: 0.023), and there was no difference in the colon ascendens and descendens. Conclusions Discontinuing metformin for 48 h before undergoing an FDG PET/CT still gives a high uptake in the distal parts of the colon when compared with non-diabetic patients who are not using metformin. Discontinuing metformin for 48 h seems to be useful for scanning the more proximal segments of the colon.
- Published
- 2020
- Full Text
- View/download PDF