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29 results on '"Hedman, Curtis J."'

4. Suspended microfluidics

Author

Casavant, Benjamin P., Berthier, Erwin, Theberge, Ashleigh B., Berthier, Jean, Montanez-Sauri, Sara I., Bischel, Lauren L., Brakke, Kenneth, Hedman, Curtis J., Bushman, Wade, Keller, Nancy P., and Beebe, David J.

Published
2013

13. Circulating serum xenoestrogens and mammographic breast density

Author

Sprague, Brian L, primary, Trentham-Dietz, Amy, additional, Hedman, Curtis J, additional, Wang, Jue, additional, Hemming, Jocelyn DC, additional, Hampton, John M, additional, Buist, Diana SM, additional, Aiello Bowles, Erin J, additional, Sisney, Gale S, additional, and Burnside, Elizabeth S, additional

Published
2013
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16. Mammographic Breast Density and Serum Phytoestrogen Levels

Author

Lowry, Sarah J., primary, Sprague, Brian L., additional, Aiello Bowles, Erin J., additional, Hedman, Curtis J., additional, Hemming, Jocelyn, additional, Hampton, John M., additional, Burnside, Elizabeth S., additional, Sisney, Gale A., additional, Buist, Diana S.M., additional, and Trentham-Dietz, Amy, additional

Published
2012
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26. Measurement of 25-hydroxyvitamin D2&3 and 1,25-dihydroxyvitamin D2&3 by tandem mass spectrometry: A primate multispecies comparison.

Author

Ziegler, Toni E., Kapoor, Amita, Hedman, Curtis J., Binkley, Neil, and Kemnitz, Joseph W.

Subjects
VITAMIN D, PRIMATOLOGY, PRIMATES, LIQUID chromatography-mass spectrometry, CALLITHRIX jacchus, RHESUS monkeys, HEALTH
Abstract

Vitamin D metabolites are widely studied for their roles in bone health, immune functions, and other potential physiologic roles in humans. However, the optimal blood levels of vitamin D metabolites are still unclear. Various methods for measuring vitamin D metabolites have been used and recently liquid chromatography tandem mass spectroscopy (LC-MS/MS) has been adopted as the gold standard for vitamin D metabolite measurement. Here, we report the use of LC-MS/MS to measure 25-hydroxyvitamin D (25(OH)D2&3), and 1,25-dihydroxyvitamin D (1,25(OH)2D2&3), in three laboratory nonhuman primate species: common marmoset ( Callithrix jacchus), rhesus macaque ( Macaca mulatta), and cynomolgus macaque ( Macaca fascicularis), and compare them to humans using the same technique. The nonhuman primates showed blood levels for 25(OH)D3 and 1,25(OH)2D3 significantly higher than human values with marmosets having the highest levels. Marmoset samples showed significantly more variability among individuals than those from macaques for both metabolites, but all three nonhuman primate species exhibited large variation within species for both 25(OH)D2&3 and 1,25(OH)2D2&3. Marmoset females had significantly lower values than the males for 25(OH)D3, while rhesus males showed a significant decrease in 25(OH)D3 with age. The most striking finding is the variation within species for vitamin D levels even in laboratory primates that have a controlled diet, UV exposure, and in some cases, genetic constraints. Similar variation in 25(OH)D responses to a fixed dose of oral vitamin D supplementation has been reported in humans. We suggest that these species can provide primate models for examining the factors influencing variation in the levels of vitamin D necessary for human and nonhuman primate health. Am. J. Primatol. 77:801-810, 2015. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2015
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27. Development of a sensitive LC/MS/MS method for vitamin D metabolites: 1,25 Dihydroxyvitamin D2&3 measurement using a novel derivatization agent.

Author

Hedman, Curtis J., Wiebe, Donald A., Dey, Subhakar, Plath, Josh, Kemnitz, Joseph W., and Ziegler, Toni E.

Subjects
*VITAMIN D metabolism, *LIQUID chromatography-mass spectrometry, *DERIVATIZATION, *BLOOD serum analysis, *IONIZING radiation
Abstract

Highlights: [•] 1,25 dihydroxyvitamin D2, D3 is the active form of vitamin D and requires sensitive methods for measuring in human serum. [•] A new ionizing agent, Amplifex, was tested for its ability to enhance liquid chromatography/mass spectrometry measurement. [•] The Amplifex method significantly correlated with values measured by standard RIA and mass spectrometry. [•] Sensitivity of 10 fold resulted over other derivatizing methods. [•] This new method resulted in increased sensitivity and required half the sample volume of other methods. [ABSTRACT FROM AUTHOR]

Published
2014
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28. Serum Factors and Clinical Characteristics Associated with Serum E-Screen Activity.

Author

Jue Wang, Trentham-Dietz, Amy, Hemming, Jocelyn D. C., Hedman, Curtis J., and Sprague, Brian L.

Abstract

The article presents the study which assessed the effectiveness of the serum E-Screen activity as a biomarker for breast cancer risk. In the study, several circulating endogenous and exogenous serum molecules, as well as patient factors linked with breast cancer risk like body mass index, alcohol consumption, and mammographic breast density were evaluated. Based on the results, E-Screen activity could be an effective biomarker in breast cancer studies.

Published
2013
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29. Authors' response.

Author

Sprague, Brian L, Trentham-Dietz, Amy, Hedman, Curtis J, Wang, Jue, Hemming, Jocelyn D C, Hampton, John M, Buist, Diana S M, Bowles, Erin J Aiello, and Burnside, Elizabeth S

Subjects
BREAST abnormalities, BREAST tumors, ESTROGEN
Published
2013

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