90 results on '"Hedin J"'
Search Results
2. First Results from the MATS Satellite Mission
- Author
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Gumbel, J., Megner, L., Murtagh, D., Ivchenko, N., Christenen, O., Linder, B., Hedin, J., Stegman, J., and Lindstein, C.
- Abstract
Global three-dimensional data are a key to understanding gravity waves in the mesosphere and lower thermosphere. In November 2022, the Swedish MATS satellite was launched into orbit to address this need. MATS applies space-borne limb imaging in combination with tomographic and spectroscopic analysis to study 3D atmospheric structures over a wide range of spatial scales. Measurement targets are O2 Atmospheric Band airglow in the near infrared, and sunlight scattered from noctilucent clouds in the ultraviolet. This presentation provides an overview over first results from the mission. This includes an outlook on data availability, and examples of usage of the data., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)
- Published
- 2023
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3. In-situ detection of noctilucent cloud particles by the Colorado Dust Detectors onboard the PHOCUS sounding rocket
- Author
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Sternovsky, Z., Robertson, S., Dickson, S., Gumbel, J., Hedin, J., Strelnikov, B., Asmus, H., and Havnes, O.
- Published
- 2014
- Full Text
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4. Multi-radar observations of polar mesosphere summer echoes during the PHOCUS campaign on 20–22 July 2011
- Author
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Belova, E., Kirkwood, S., Latteck, R., Zecha, M., Pinedo, H., Hedin, J., and Gumbel, J.
- Published
- 2014
- Full Text
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5. On the size distribution of collision fragments of NLC dust particles and their relevance to meteoric smoke particles
- Author
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Havnes, O., Gumbel, J., Antonsen, T., Hedin, J., and La Hoz, C.
- Published
- 2014
- Full Text
- View/download PDF
6. Internal Hernia After Gastric Bypass: A New and Simplified Technique for Laparoscopic Primary Closure of the Mesenteric Defects
- Author
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Aghajani, Ebrahim, Jacobsen, Hedin J., Nergaard, Bent Johnny, Hedenbro, Jan L., Leifson, Björn Geir, and Gislason, Hjörtur
- Published
- 2012
- Full Text
- View/download PDF
7. O2 density and temperature profiles retrieving from direct solar Lyman-alpha radiation measurements
- Author
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Guineva, V., Witt, G., Gumbel, J., Khaplanov, M., Werner, R., Hedin, J., Neichev, S., Kirov, B., Bankov, L., Gramatikov, P., Tashev, V., Popov, M., Hauglund, K., Hansen, G., Ilstad, J., and Wold, H.
- Published
- 2009
- Full Text
- View/download PDF
8. Differentiated Service Code Point and Explicit Congestion Notification Monitoring in the Two-Way Active Measurement Protocol (TWAMP)
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Hedin, J., primary, Mirsky, G., additional, and Baillargeon, S., additional
- Published
- 2016
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9. Tableting study for ODTs
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Berthoumieu, D., Trannoy, P., Cordoliani, J. F., Francois A., and Hedin, J. M.
- Subjects
Excipients -- Research ,Excipients -- Properties ,Pharmaceutical industry -- Research ,Business ,Business, international ,Chemicals, plastics and rubber industries ,Engineering and manufacturing industries - Abstract
The use of excipient Pearlitol Flash in the formulation of orally disintegrating tablets is examined. The excipient is a combination of mannitol and starch. It has been found to rapidly disintegrate in water resulting in quick absorption.
- Published
- 2010
10. Use of O2 airglow for calibrating direct atomic oxygen measurements from sounding rockets
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Hedin, J., Gumbel, J., Stegman, J., and Witt, G.
- Abstract
Accurate knowledge about the distribution of atomic oxygen is crucial for many studies of the mesosphere and lower thermosphere. Direct measurements of atomic oxygen by the resonance fluorescence technique at 130 nm have been made from many sounding rocket payloads in the past. This measurement technique yields atomic oxygen profiles with good sensitivity and altitude resolution. However, accuracy is a problem as calibration and aerodynamics make the quantitative analysis challenging. Most often, accuracies better than a factor 2 are not to be expected from direct atomic oxygen measurements. As an example, we present results from the NLTE (Non Local Thermodynamic Equilibrium) sounding rocket campaign at Esrange, Sweden, in 1998, with simultaneous O2 airglow and O resonance fluorescence measurements. O number densities are found to be consistent with the nightglow analysis, but only within the uncertainty limits of the resonance fluorescence technique. Based on these results, we here describe how better atomic oxygen number densities can be obtained by calibrating direct techniques with complementary airglow photometer measurements and detailed aerodynamic analysis. Night-time direct O measurements can be complemented by photometric detection of the O2 (b1∑g+−X3∑g-) Atmospheric Band at 762 nm, while during daytime the O2 (a1Δg−X3∑g-) Infrared Atmospheric Band at 1.27 μm can be used. The combination of a photometer and a rather simple resonance fluorescence probe can provide atomic oxygen profiles with both good accuracy and good height resolution.
- Published
- 2018
11. Na layer response to geomagnetic activities: statistical analysis based on Odin/OSIRIS data
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T. Tsuda, T., Nakamura, T., K. Ejiri, M., Nishiyama, T., Hosokawa, K., Takahashi, T., Gumbel, J., and Hedin, J.
- Abstract
第7回極域科学シンポジウム/横断セッション:[IM] 中空大気・熱圏11月30日(水)国立極地研究所1階交流アトリウム
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- 2016
12. Statistical investigation of Na layer response to geomagnetic activity using resonance scattering measurements by Odin/OSIRIS
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Tsuda, T. T., primary, Nakamura, T., additional, Ejiri, M. K., additional, Nishiyama, T., additional, Hosokawa, K., additional, Takahashi, T., additional, Gumbel, J., additional, and Hedin, J., additional
- Published
- 2017
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13. First global observations of the mesospheric potassium layer
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Dawkins, ECM, Plane, JMC, Chipperfield, MP, Feng, W, Gumbel, J, Hedin, J, Höffner, J, and Friedman, JS
- Abstract
Metal species, produced by meteoric ablation, act as useful tracers of upper atmosphere dynamics and chemistry. Of these meteoric metals, K is an enigma: at extratropical latitudes, limited available lidar data show that the K layer displays a semiannual seasonal variability, rather than the annual pattern seen in other metals such as Na and Fe. Here we present the first near-global K retrieval, where K atom number density profiles are derived from dayglow measurements made by the Optical Spectrograph and Infrared Imager System spectrometer on board the Odin satellite. This robust retrieval produces density profiles with typical layer peak errors of ±15% and a 2 km vertical grid resolution. We demonstrate that these retrieved profiles compare well with available lidar data and show for the first time that the unusual semiannual behavior is near-global in extent. This new data set has wider applications for improving understanding of the K chemistry and of related upper atmosphere processes.
- Published
- 2014
14. New vanadium-microalloyed bainitic 700 MPa strip steel product
- Author
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Hutchinson, B., primary, Siwecki, T., additional, Komenda, J., additional, Hagström, J., additional, Lagneborg, R., additional, Hedin, J.-E., additional, and Gladh, M., additional
- Published
- 2013
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15. In situ observations of meteor smoke particles (MSP) during the Geminids 2010: constraints on MSP size, work function and composition
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Rapp, M., primary, Plane, J. M. C., additional, Strelnikov, B., additional, Stober, G., additional, Ernst, S., additional, Hedin, J., additional, Friedrich, M., additional, and Hoppe, U.-P., additional
- Published
- 2012
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16. Observations of NO in the upper mesosphere and lower thermosphere during ECOMA 2010
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Hedin, J., primary, Rapp, M., additional, Khaplanov, M., additional, Stegman, J., additional, and Witt, G., additional
- Published
- 2012
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17. Effects of finite drift orbit width and RF-induced spatial transport on plasma heated by ICRH
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Hellsten, Torbjörn, Johnson, Thomas, Carlsson, J., Eriksson, L.-G., Hedin, J., Laxåback, Martin, Mantsinen, M., Hellsten, Torbjörn, Johnson, Thomas, Carlsson, J., Eriksson, L.-G., Hedin, J., Laxåback, Martin, and Mantsinen, M.
- Abstract
The effects of RF-induced transport and orbit topology of resonant ions are analysed for high power ion cyclotron resonance heating (ICRH). These effects are found to play important roles in the details of the high-energy part of the distribution function, and affect the driven current and momentum transfer to the background plasma. The finite drift orbit width broadens the power deposition and leads to losses of high-energy ions intercepted by the wall. RF-induced transport of resonant ions across magnetic flux surfaces appears due to the toroidal acceleration of resonant ions interacting with waves having a finite toroidal mode number. Heating with waves propagating parallel to the current leads to a drift of the turning points of trapped resonant ions towards the midplane. As the turning points meet, the orbits will de-trap, preferentially into co-current passing orbits, which may ultimately be displaced to the low field side of the magnetic axis. Ions with such orbits are a typical feature in plasmas heated with directed toroidal mode spectra of waves propagating parallel to the plasma current. These ions will be subjected to a strong RF diffusion partly caused by the focusing of the wave field and partly by the Doppler shifted cyclotron resonance, as it approaches tangency with the drift orbit. The resonance condition puts a limitation on the achievable energy for these ions, which is more severe than for corresponding trapped ions. This results in a rather flat tail up to a critical energy, above which the tail rapidly decays. Heating with waves propagating anti-parallel with the plasma current curtails the energy of the trapped ions due to a vertical outward drift of the turning points of the trapped ions. Heating with symmetric spectra, in particular with waves with low magnitude of the toroidal mode numbers, gives rise to high-energy trapped ions with wide orbits, of which the maximum energy is either restricted by the fact that the RF diffusion vanishes du, QC 20100507
- Published
- 2004
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18. Internal Hernia After Gastric Bypass: A New and Simplified Technique for Laparoscopic Primary Closure of the Mesenteric Defects
- Author
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Aghajani, Ebrahim, primary, Jacobsen, Hedin J., additional, Nergaard, Bent Johnny, additional, Hedenbro, Jan L., additional, Leifson, Björn Geir, additional, and Gislason, Hjörtur, additional
- Published
- 2011
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19. The influence of finite drift orbit width on ICRF heating in toroidal plasmas
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Hedin, J., Hellsten, Torbjörn A. K., Eriksson, L. G., Johnson, Thomas J., Hedin, J., Hellsten, Torbjörn A. K., Eriksson, L. G., and Johnson, Thomas J.
- Abstract
Ion cyclotron resonance heating in a toroidal plasma not only increases the perpendicular energy of the resonating ions but also results in their spatial transport. Depending on the direction of propagation of the waves, the ions will either drift inwards or outwards giving rise to an RF induced rotation with the toroidal torque component in the co-current or counter-current directions, respectively. It is found that the spatial transport induced by the RF field, the topology of the ion drift orbits and a wave field consistent with ion absorption are important for determining the distribution function of the heated species. Studies of ICRF heating with the self-consistent code SELFO reveal new features such as the formation of non-standard passing orbits residing on the low field side of the magnetic axis. For a symmetric spectrum the drift terms will in general not cancel. Some classes of orbit will be subjected only to an inward drift and others only to an outward drift. The lack of cancellation of the drift terms is further enhanced by the self-consistent coupling, increasing the absorption for waves propagating parallel to the plasma current, but not for waves propagating in the antiparallel direction. This results in a strong inward pinch also for symmetric wave spectra as well as for typical experimental spectra, with the dominant peak in the counter-plasma-direction., QC 20100525
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- 2002
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20. Use of O2 airglow for calibrating direct atomic oxygen measurements from sounding rockets
- Author
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Hedin, J., primary, Gumbel, J., additional, Stegman, J., additional, and Witt, G., additional
- Published
- 2009
- Full Text
- View/download PDF
21. Optical studies of noctilucent clouds in the extreme ultraviolet
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Hedin, J., primary, Gumbel, J., additional, Khaplanov, M., additional, Witt, G., additional, and Stegman, J., additional
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- 2008
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22. The influence of non-standard orbits on ICRH power deposition in tokamaks
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Hedin, J., Hellsten, Torbjörn A. K., Eriksson, L. G., Hedin, J., Hellsten, Torbjörn A. K., and Eriksson, L. G.
- Abstract
The distribution function and power deposition during ICRH in a tokamak plasma are analysed. The importance of self-consistent calculations and the formation of son-standard drift orbits are addressed. It is found that for high power ICRH, the presence of non-standard orbits are crucial for describing the distribution function. For a standard minority heating scenario with the ion cyclotron resonance located at the high field side, the absorption of the wave power is shifted to the low field side (LFS) because of the orbit topology and the evolving wave field profile. The high energy tail of the distribution function of the resonating ions is found to be dominated by ions in passing orbits, of which some reside completely on the LFS of the tokamak., QC 20100525
- Published
- 2000
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23. Ion cyclotron current drive studies
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Johnson, Thomas, Hedin, J, Hellsten, Torbjörn, Johnson, Thomas, Hedin, J, and Hellsten, Torbjörn
- Abstract
QC 20100621
- Published
- 2000
24. On the efficiency of rocket-borne particle detection in the mesosphere
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Hedin, J., primary, Gumbel, J., additional, and Rapp, M., additional
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- 2007
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25. Observations of positively charged nanoparticles in the nighttime polar mesosphere
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Rapp, M., primary, Hedin, J., additional, Strelnikova, I., additional, Friedrich, M., additional, Gumbel, J., additional, and Lübken, F.-J., additional
- Published
- 2005
- Full Text
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26. Effects of finite drift orbit width and RF-induced spatial transport on plasma heated by ICRH
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Hellsten, T, primary, Johnson, T, additional, Carlsson, J, additional, Eriksson, L.-G, additional, Hedin, J, additional, Laxåback, M, additional, and Mantsinen, M, additional
- Published
- 2004
- Full Text
- View/download PDF
27. The influence of finite drift orbit width on ICRF heating in toroidal plasmas
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Hedin, J., primary, Hellsten, T., additional, Eriksson, L.-G., additional, and Johnson, T., additional
- Published
- 2002
- Full Text
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28. Teaching computational methods for partial differential equations using the Web
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Jaun, A., primary, Hedin, J., additional, and Johnson, T., additional
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- 2001
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29. Effects of finite drift orbit width and RF-induced spatial transport on plasmas heated by ICRH.
- Author
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Hellsten, T., Hedin, J., Carlsson, J., Eriksson, L.-G., Johnson, T., Laxa˚back, M., and Mantsinen, M.
- Subjects
- *
RADIO frequency , *PLASMA heating , *TORQUE - Abstract
The finite drift orbit width, orbit topology and RF-induced transport of resonant ions play an important role in many high power ICRH scenarios in hot plasmas. Wave-particle interactions with waves propagating in the co-current direction produce an inward drift of trapped orbits ultimately detrapping them into passing orbits when the turning points meet. The drift of ions across magnetic flux surfaces gives rise to a torque on the background plasma. Due to the finite orbit width and the finite Doppler shift of the cyclotron resonance, the drifts and hence the torques do not cancel even for toroidally symmetric wave spectra. An inward drift appears near the centre and an outward further out giving rise to a differential acceleration of the plasma. [ABSTRACT FROM AUTHOR]
- Published
- 2001
30. RF-induced pinch of resonant [sup 3]He minority ions in JET.
- Author
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Johnson, T., Hellsten, T., Mantsinen, M., Kiptily, V., Sharapov, S., Hedin, J., Noterdaeme, J.-M., Mayoral, M.-L., and Nguyen, F.
- Subjects
RADIO frequency ,HELIUM ,IONS ,DIAMAGNETISM - Abstract
The RF-induced pinch of ³He minority ions has been observed in JET affecting the diamagnetic energy, the fast ion energy content, the sawtooth period, the Alfvén eigenmode excitation and the γ-emission. Further, the γ-emission is consistent with RF-detrapping into co-current passing orbits. The results from the SELFO code are consistent with the observations. [ABSTRACT FROM AUTHOR]
- Published
- 2001
31. The influence of non-standard orbits on ICRH power deposition in tokamaks
- Author
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Hedin, J, primary, Hellsten, T, additional, and Eriksson, L.-G, additional
- Published
- 2000
- Full Text
- View/download PDF
32. New vanadium-microalloyed bainitic 700 MPa strip steel product.
- Author
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Hutchinson, B., Siwecki, T., Komenda, J., Hagström, J., Lagneborg, R., Hedin, J.-E., and Gladh, M.
- Published
- 2014
- Full Text
- View/download PDF
33. Self-consistent calculations of ICRH in toroidal plasmas
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Hedin, J., primary and Hellsten, T., additional
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- 1999
- Full Text
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34. Toroidal effects on ICRF heating and current drive
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Carlsson, J., primary, Hellsten, T., additional, and Hedin, J., additional
- Published
- 1999
- Full Text
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35. New mechanisms of minority ion cyclotron current drive
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Carlsson, J., primary, Hellsten, T., additional, and Hedin, J., additional
- Published
- 1998
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36. Parasitic absorption by fusion born -particles in ICRF heated plasmas
- Author
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Hedin, J, primary, Carlsson, J, additional, Hellsten, T, additional, and Jaun, A, additional
- Published
- 1998
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37. O2 density and temperature profiles retrieving from direct solar Lyman-alpha radiation measurements.
- Author
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Guineva, V., Witt, G., Gumbel, J., Khaplanov, M., Werner, R., Hedin, J., Neichev, S., Kirov, B., Bankov, L., Gramatikov, P., Tashev, V., Popov, M., Hauglund, K., Hansen, G., Ilstad, J., and Wold, H.
- Abstract
The resonance transition
2 P-2 S of the atomic hydrogen (Lyman-alpha emission) is the strongest and most conspicuous feature in the solar EUV spectrum. The Lyman-alpha radiation transfer depends on the resonance scattering from the hydrogen atoms in the atmosphere and on the O2 absorption. Since the Lyman-alpha extinction in the atmosphere is a measure for the column density of the oxygen molecules, the atmospheric O2 density and temperature profiles can be calculated thereof. A detector of solar Lyman-alpha radiation was manufactured in the Stara Zagora Department of the Solar-Terrestrial Influences Laboratory (STIL). Its basic part is an ionization camera, filled in with NO. A 60 V power supply is applied to the chamber. The produced photoelectric current from the sensor is fed to a two-channel amplifier, providing analog signal. The characteristics of the Lyman-alpha detector were studied. It passed successfully all tests and the results showed that the so-designed instrument could be used in rocket experiments to measure the Lymanalpha flux. From the measurements of the detector, the Lyman-alpha vertical profile can be obtained. Programs are created to compute the O2 density, atmospheric power and temperature profiles based on Lymanalpha data. The detector design appertained to ASLAF project (Attenuation of the Solar Lyman-Alpha Flux), a scientific cooperation between STIL—Bul.Acad.Sci., Stara Zagora Department and the Atmospheric Physics Group at the Department of Meteorology (MISU), Stockholm University, Sweden. The joint project was part of the rocket experiment HotPay I, in the ALOMAR eARI Project, EU’s 6th Framework Programme, Andøya Rocket Range, Andenes, Norway. The project is partly financed by the Bulgarian Ministry of Science and Education. [ABSTRACT FROM AUTHOR]- Published
- 2009
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38. Parasitic absorption by fusion born or-particles in ICRF heated plasmas
- Author
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Hedin, J, Carlsson, J, Hellsten, T, and Jaun, A
- Published
- 1998
39. Toroidal effects on ICRF heating and current drive
- Author
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Hedin, J [Alfoen Laboratory, Royal Institute of Technology, S-100 44 Stockholm, (Sweden)]
- Published
- 1999
- Full Text
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40. Combination of Tevatron searches for the standard model Higgs boson in the W+W- decay mode
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Maxim Perfilov, B. Carls, V. Sorin, P. Lukens, Kevin Lannon, P. Verdier, Guenakh Mitselmakher, Guillelmo Gomez-Ceballos, Marcelo Vogel, V. A. Kuzmin, U. K. Yang, Chris Hays, W. T. Fedorko, Y. A. Yatsunenko, M. Mussini, Y. C. Yang, J. Keung, G. C. Blazey, D. Torretta, A. F. Barfuss, L. Bellantoni, Viatcheslav Stolin, Frank Würthwein, M. Shochet, C. Plager, F. Canelli, V. A. Bezzubov, A. Hocker, P. D. Grannis, Jun Guo, Q. Z. Li, Mark Kruse, Alison Lister, J. P. Fernandez, J. P. Negret, J. Nett, Stefano Giagu, Paul Tipton, G. L. Strycker, C. Mesropian, R. Yamada, D. N. Brown, P. Squillacioti, Kazuhiko Hara, J. Osta, Carlos Avila, L. E. Kirsch, Ricardo Eusebi, J. Galyardt, Alexei Safonov, R. Luna-Garcia, Raimund Ströhmer, V. Simak, D. Krop, Sabine Lammers, Jonas Rademacker, D. Amidei, J. M. Heuser, J. Sekaric, Michael A. Strauss, Jean-Francois Grivaz, K. Devaughan, A. T. Goshaw, P. Padley, Michael Hildreth, P. Skubic, A. Semenov, D. Clark, J. Boudreau, Wendy Taylor, M. Pangilinan, Jason Nielsen, G. Introzzi, B. Casal, Mitchell Wayne, N. Miladinovic, Y. Tu, H. Schellman, J. M. Kohli, K. Potamianos, Z. Gunay-Unalan, Darren Price, A. Sanchez-Hernandez, M. Wiok, Sergo Jindariani, Fedor Prokoshin, P. Jonsson, Thomas Hebbeker, Katsufumi Sato, A. J. Slaughter, Stefan Grünendahl, S. Cihangir, V. Zutshi, Yasuyoshi Nagai, Francesco Crescioli, S. Uzunyan, S. W. Lee, P. Ttito-Guzmán, T. Okusawa, B. Gómez, R. Madrak, Chong-Yu Xu, J. Naganoma, B. Tuchming, P. Wagner, V. Bunichev, Shinhong Kim, J. Budagov, Fabrice Couderc, K. Makhoul, Manfred Paulini, B. Tiller, Dmitri Tsybychev, R. L. McCarthy, Thomas LeCompte, Manuela Campanelli, I. Lazzizzera, Eva Halkiadakis, M. Gold, Tetsuo Arisawa, C. Neu, Amnon Harel, W. M. Lee, K. Kondo, Mary Beth Adams, D. Whiteson, I. Shreyber, K. Yamamoto, Malte Renz, Andrew Askew, R. L. Lander, G. De Lorenzo, A. Savoy-Navarro, Allan G Clark, Roger Moore, D. O. Litvintsev, S. Söldner-Rembold, A. Anastassov, G. Giurgiu, L. Sartori, Sooran Kim, O. Poukhov, A. Jonckheere, H. E. Fisk, P. Lebrun, M. N. Mondragon, I. Hall, A. Lobodenko, Wolfgang Wagner, Liang Li, J. C. Yun, J. Lueck, Stephen Wimpenny, S. Carrillo, J. Backusmayes, Martin Grunewald, Nicola D'Ascenzo, J. A. Appel, P. H. Beauchemin, M. Heck, D. Beecher, Peter McIntyre, G. Pauletta, M. Martínez, J. Patrick, E. Strauss, Guennadi Borissov, M. Jones, C. Pagliarone, D. Menezes, Intae Yu, Oliver Stelzer-Chilton, Th Muller, D. W. Jang, R. Van Kooten, B. Y. Han, I. Heredia-De La Cruz, Michael L. Norman, Yongsun Kim, Lev Dudko, Milos Lokajicek, D. Karmanov, M. M. Deninno, Markus Wobisch, R. Magaña-Villalba, S. W. Cho, G. Obrant, B. Whitehouse, S. Y. Jun, Julia Thom, W. C. Fisher, Adrian Buzatu, V. Boisvert, Daria Zieminska, Suneel Dutt, J. E. Kim, Aran Garcia-Bellido, M. D. Corcoran, S. Cabrera, D. E. Pellett, M. Binkley, R. D. Schamberger, M. Corbo, Y. C. Chen, F. Guo, A. J. Martin, C. Vellidis, Darien Wood, Y. Shon, D. K. Cho, T. R. Wyatt, E. Brubaker, Shabnam Jabeen, S. De Cecco, A. Dubey, G. Grenier, Hwi Dong Yoo, Zdenek Hubacek, L. Santi, A. Alton, Meng Wang, Neeti Parashar, L. Pondrom, E. Wicklund, Christoph Paus, C. P. Buszello, S. Hou, A. Das, M. Sosebee, A. Manousakis-Katsikakis, Emily Nurse, M. Merkin, L. Han, Giorgio Chiarelli, A. Rahaman, J. Huston, J. D. Lewis, Yuehong Xie, T. Scanlon, S. Kermiche, W. H. Chung, M. Rominsky, L. Brigliadori, V. M. Abazov, D. Buchholz, I. Ripp-Baudot, R. McNulty, M. Hare, M. Tecchio, A. Gessler, Helio Nogima, I. Razumov, S. Blessing, M. Zielinski, V. Rusu, A. Elagin, Vyacheslav Krutelyov, G. S. Muanza, Jay Dittmann, W. Ashmanskas, D. Hirschbuehl, H. C. Fang, Frederic Deliot, Michele Gallinaro, G. Savage, Peter Wittich, A. Napier, A. Meyer, Scott Snyder, J. Hays, S. Tokar, Suman Bala Beri, C.S. Johnson, G. Sajot, V. Hynek, Robert Hirosky, Alberto Annovi, P. Murat, Y. Hu, D. J. Cox, A. Di Canto, V. Khotilovich, Y. Seiya, O. Atramentov, Elizaveta Shabalina, M. Lancaster, G. Alkhazov, Y. Zheng, Jian Tang, L. Oakes, A. Gresele, Y. N. Kharzheev, A. Varganov, Sudhir Malik, E. G. Zverev, M. Vidal, Ia Iashvili, G. Manca, P. Roy, Raymond Brock, Robin Erbacher, M. Datta, R. Beuselinck, C. Cuenca Almenar, Javier Cuevas, Jean-Arcady Meyer, J. Mülmenstädt, D. V. Bandurin, S. Greder, Y. W. Liu, Iain Alexander Bertram, Virgil E Barnes, M. Padilla, L. Bagby, M. S. Rangel, Jahred Adelman, Jane Nachtman, Graham Wilson, Sergio F Novaes, S. Hossain, B. Jayatilaka, Kyung-Suk Cho, R. E. Hughes, P. Rich, T. Rodriguez, D. Gillberg, H. Wolfe, B. Sanghi, Suyong Choi, J. Parsons, G. Velev, J. M. Hauptman, Cecilia Elena Gerber, V. M. Podstavkov, G. Chlachidze, Michael Rijssenbeek, S. Zelitch, Jeannine Wagner-Kuhr, M. A. Strang, Brajesh C Choudhary, D. Lucchesi, Bernd Stelzer, S. Tkaczyk, F. Vázquez, P. Svoisky, C. Zeitnitz, J. Yamaoka, Arnulf Quadt, Petar Maksimovic, A. Juste, E. De La Cruz-Burelo, A. Attal, E. Pueschel, T. Wright, S. Grinstein, Todd Adams, K. M. Chan, A. S. 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Kwang, M. Hurwitz, S. R. Hahn, M. Vesterinen, N. Osman, A. Deisher, T. R. Junk, Patrick Slattery, A. Chandra, J. Yoh, D. A. Stoyanova, C. L. McGivern, Gervasio Gomez, Michael Begel, Andrey Korytov, Eduardo De Moraes Gregores, Luiz Mundim, R. Takashima, T. H. Burnett, Amitabh Lath, Anna Sfyrla, Paola Giannetti, B. A. Barnett, Giorgio Apollinari, J. A. Benitez, Teruki Kamon, P. Mazzanti, Craig Blocker, Ulrich Heintz, D. Cauz, Kaori Maeshima, P. K. Mal, H. S. Lee, Frank Filthaut, Paolo Mastrandrea, M. Diesburg, P. Wilson, J. E. Garcia, A. Tanasijczuk, T. Davies, C. S. Hill, Sandra Leone, S. Uvarov, B. Quinn, W. K. Sakumoto, C. Schwanenberger, Alice Bean, C. Grosso-Pilcher, I. Oksuzian, N. Goldschmidt, Volker Buescher, Peter Bussey, T. Gadfort, Maria Elena Pol, Kai Yi, C. M. Ginsburg, R. Roser, Ivan Vila, P. F. Shepard, B. Rutherford, Alexander Ivanov, N. Van Remortel, S. C. Hsu, Reisaburo Tanaka, Guido Volpi, Nikos Varelas, O. González, Bing Zhou, Luis Mendoza, R. K. Shivpuri, S. Donati, Kenichi Hatakeyama, M. Franklin, D. R. Claes, Gavin Davies, Philippe Calfayan, Itsuo Nakano, Harald Fox, S. M. Lietti, Y. Scheglov, J. C. Freeman, Kaushik De, A. Ruiz, Giuseppe Latino, Alan Garfinkel, Jan Stark, Fabrizio Margaroli, S. Errede, Maiko Takahashi, Henry Lubatti, J. Cammin, I. A. Vasilyev, Vipin Bhatnagar, A. Cerri, R. Partridge, Markus Frank, P. M. Tuts, D. MacQueen, H. Gerberich, Kenneth Bloom, V. L. Malyshev, Mark Neubauer, R. Orava, G. Lungu, R. D. Field, D. J. Kong, W. C. Yang, Department of Physics, Helsinki Institute of Physics, CDF Collaboration, D0 Collaboration, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CDF, D0, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidad de Cantabria, T. 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STENTZ, V. STOLIN, D. A. STOYANOVA, J. STRANDBERG, M. A. STRANG, E. STRAUSS, M. STRAUSS, R. STRÖHMER, J. STROLOGAS, D. STROM, G. L. STRYCKER, L. STUTTE, J. S. SUH, A. SUKHANOV, I. SUSLOV, P. SVOISKY, A. TAFFARD, M. TAKAHASHI, R. TAKASHIMA, Y. TAKEUCHI, R. TANAKA, A. TANASIJCZUK, J. TANG, W. TAYLOR, M. TECCHIO, P. K. TENG, J. THOM, J. THOME, G. A. THOMPSON, E. THOMSON, B. TILLER, P. TIPTON, M. TITOV, S. TKACZYK, D. TOBACK, S. TOKAR, V. V. TOKMENIN, K. TOLLEFSON, T. TOMURA, D. TONELLI, S. TORRE, D. TORRETTA, P. TOTARO, M. TROVATO, S.-Y. TSAI, D. TSYBYCHEV, P. TTITO-GUZMÁN, B. TUCHMING, Y. TU, C. TULLY, N. TURINI, P. M. TUTS, F. UKEGAWA, R. UNALAN, S. UOZUMI, L. UVAROV, S. UVAROV, S. UZUNYAN, P. J. VAN DEN BERG, R. VAN KOOTEN, W. M. VAN LEEUWEN, N. VAN REMORTEL, N. VARELAS, A. VARGANOV, E. W. VARNES, I. A. VASILYEV, E. VATAGAD,A, F. VÁZQUEZ,H, G. VELEV, C. VELLIDIS, P. VERDIER, L. S. VERTOGRADOV, M. VERZOCCHI, M. VESTERINEN, M. VIDAL, I. VILA, D. VILANOVA, R. VILAR, P. VINT, M. VOGEL, P. 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ZIELINSKI, D. ZIEMINSKA, L. ZIVKOVIC, S. ZUCCHELLI, V. ZUTSHI, E. G. ZVEREV, D0 (Tevatron, IHEF, IOP, FNWI), Universidad de Buenos Aires, Centro Brasileiro de Pesquisas Físicas, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Federal do ABC (UFABC), Universidade Estadual Paulista (UNESP), McGill University, Simon Fraser University, University of Science and Technology of China, Academia Sinica, Universidad de los Andes, Faculty of Mathematics and Physics, Czech Technical University in Prague, Academy of Sciences, Universidad San Francisco de Quito, University of Helsinki, CNRS/IN2P3, Institut National Polytechnique de Grenoble, Irfu/SPP, RWTH Aachen University, Universität Bonn, Universität Freiburg, Georg-August-Universität Göttingen, Karlsruhe Institute of Technology, Universität Mainz, Ludwig-Maximilians-Universität München, University of Wuppertal, University of Athens, Panjab University, Delhi University, Tata Institute of Fundamental Research, University College Dublin, Istituto Nazionale di Fisica Nucleare Bologna, University of Bologna, Istituto Nazionale di Fisica Nucleare, Sezione di Padova-Trento, University of Padova, Istituto Nazionale di Fisica Nucleare Pisa, University of Pisa, University of Siena, Scuola Normale Superiore, Sezione di Roma 1, Sapienza Università di Roma, Istituto Nazionale di Fisica Nucleare Trieste/Udine, University of Trieste, Okayama University, Osaka City University, University of Tsukuba, Waseda University, Kyungpook National University, Korea University, SungKyunKwan University, CINVESTAV, NIKHEF, Radboud University Nijmegen/NIKHEF, Joint Institute for Nuclear Research, Institution for Theoretical and Experimental Physics, Moscow State University, Institute for High Energy Physics, Petersburg Nuclear Physics Institute, Comenius University, Universitat Autonoma de Barcelona, Medioambientales y Tecnologicas, University of Cantabria, Stockholm University, University of Geneva, Glasgow University, Lancaster University, University of Liverpool, Imperial College London, University College London, The University of Manchester, University of Oxford, University of Arizona, Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Yale University, University of Florida, Florida State University, Argonne National Laboratory, Fermi National Accelerator Laboratory, University of Chicago, University of Illinois at Chicago, Northern Illinois University, Northwestern University, University of Illinois, Indiana University, Purdue University Calumet, University of Notre Dame, Purdue University, Iowa State University, University of Kansas, Kansas State University, Louisiana Tech University, The Johns Hopkins University, University of Maryland, Boston University, Northeastern University, Harvard University, Massachusetts Institute of Technology, Tufts University, Brandeis University, University of Michigan, Wayne State University, Michigan State University, University of Mississippi, University of Nebraska, Rutgers University, Princeton University, University of New Mexico, State University of New York, Columbia University, The Rockefeller University, University of Rochester, Brookhaven National Laboratory, Duke University, The Ohio State University, Langston University, University of Oklahoma, Oklahoma State University, University of Pennsylvania, Carnegie Mellon University, University of Pittsburgh, Brown University, University of Texas, Texas A and M University, Southern Methodist University, Rice University, Baylor University, University of Virginia, University of Washington, University of Wisconsin, Sezione di Cagliari, University of Toronto, TRIUMF, York University, Seoul National University, Sungkyunkwan University, Institute of Science and Technology Information, Chonnam National University, Chonbuk National University, Institute of Experimental Physics, University of Cyprus, University of Edinburgh, Fukui Prefecture, Kinki University, Universidad Iberoamericana, University of Iowa, University of California Irvine, Cornell University, University of London, University of Manchester, Inc., Nagasaki Institute of Applied Science, Obninsk State University, University de Oviedo, Texas Tech University, CSIC-Universitat de Valencia, Universidad Tecnica Federico Santa Maria, Bergische Universität Wuppertal, Yarmouk University, J. Stefan Institute, Augustana College, SLAC, ICREA/IFAE, Centro de Investigacion en Computacion-IPN, Universidad Autonoma de Sinaloa, Universiẗt Bern, University of Massachusetts Amherst, Universiteit Antwerpen, University of Bristol, University of California Santa Cruz, Chinese Academy of Sciences, Clark, Allan Geoffrey, Garcia Navarro, Jose Enrique, Lister, Alison, and Wu, Xin
- Subjects
Particle physics ,Astrophysics::High Energy Astrophysical Phenomena ,Tevatron ,FOS: Physical sciences ,General Physics and Astronomy ,Elementary particle ,ddc:500.2 ,PARTON DISTRIBUTIONS ,HADRON COLLIDERS ,QCD ,NNLO ,7. Clean energy ,01 natural sciences ,114 Physical sciences ,High Energy Physics - Experiment ,Standard Model ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Particle decay ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Grand Unified Theory ,Fermilab ,TEVATRON ,Nuclear Experiment ,010306 general physics ,Boson ,Physics ,HIGGS BOSON ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,3. Good health ,Higgs boson ,CDF ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,+W%2B+W-+|+W%3A+pair+production+|+W%3A+leptonic+decay+|+dilepton%3A+final+state+|+jet%3A+multiplicity+|+cross+section%3A+upper+limit+|+mass+dependence+|+Higgs+particle%3A+mass+|+background+|+DZERO+|+CDF+|+Batavia+TEVATRON+Coll+|+anti-p+p+-->+Higgs+particle+anything+|+anti-p+p+-->+Higgs+particle+anything+intermediate+boson+anything+|+anti-p+p+-->+Higgs+particle+anything+quark+antiquark+anything+|+1960+GeV-cms%22">Anti-p p: interaction | Higgs particle: search for | gluon gluon: fusion | intermediate boson: fusion | quark antiquark: annihilation | Higgs particle: decay | Higgs particle --> W+ W- | W: pair production | W: leptonic decay | dilepton: final state | jet: multiplicity | cross section: upper limit | mass dependence | Higgs particle: mass | background | DZERO | CDF | Batavia TEVATRON Coll | anti-p p --> Higgs particle anything | anti-p p --> Higgs particle anything intermediate boson anything | anti-p p --> Higgs particle anything quark antiquark anything | 1960 GeV-cms - Abstract
11 páginas, 4 figuras, 1 tabla.-- CDF Collaboration: et al., We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L., We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by DOE and NSF (USA), CONICET and UBACyT (Argentina), CNPq, FAPERJ, FAPESP and FUNDUNESP (Brazil), CRC Program, CFI, NSERC and WestGrid Project (Canada), CAS and CNSF (China), Colciencias (Colombia), MSMT and GACR (Czech Republic), Academy of Finland (Finland), CEA and CNRS/IN2P3 (France), BMBF and DFG (Germany), Ministry of Education, Culture, Sports, Science and Technology (Japan), World Class University Program, National Research Foundation (Korea), KRF and KOSEF (Korea), DAE and DST (India), SFI (Ireland),INFN (Italy), CONACyT (Mexico), NSC(Republic of China), FASI, Rosatom and RFBR (Russia), Slovak R&D Agency (Slovakia), Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010 (Spain), The Swedish Research Council (Sweden), Swiss National Science Foundation (Switzerland), FOM (The Netherlands), STFC and the Royal Society (UK), and the A.P. Sloan Foundation (USA).
- Published
- 2010
- Full Text
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41. Bi-layer formation of imidazole-modified ethyl(hydroxyethyl)cellulose at a hydrophobic surface as monitored by QCM-D
- Author
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Dan Isaksson, Markus Andersson, Jesper Hedin, Magnus Nydén, Hedin, J, Isaksson, D, Andersson, Elizabeth Rakus, and Nyden, Bo Magnus
- Subjects
chemistry.chemical_classification ,Materials science ,Metal ions in aqueous solution ,Quartz crystal microbalance ,Polymer ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Biomaterials ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Adsorption ,chemistry ,Transition metal ,Polymer chemistry ,Imidazole ,EHEC ,imidazole ,QCM-D ,bi-layer ,cellulose derivative ,Cellulose ,Layer (electronics) - Abstract
The adsorption behaviour of ethyl(hydroxyethyl)cellulose chemically modified with imidazole (Im-EHEC) at hydrophobic surfaces has been studied with QCM-D. The very slow adsorption isotherm was due to a continuous polymer film reconfiguration and exchange of different sized polymers. The thickness of the film was about 30 nm. The polymers adsorbed Cu(2+) ions into the film from a CuCl(2) solution and a bi-layer was formed when Im-EHEC was added a second time. The second polymer film was only 7 nm thick but highly viscoelastic. After rinsing with water the metal ions was flushed away and the second Im-EHEC layer was released. The imidazole modification of EHEC enables interaction with transition metal ions and opens up for new applications for cellulose based materials.
- Published
- 2009
42. Metapopulation dynamics over 25 years of a beetle, Osmoderma eremita, inhabiting hollow oaks.
- Author
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Lindman L, Larsson MC, Mellbrand K, Svensson GP, Hedin J, Tranberg O, and Ranius T
- Subjects
- Animals, Ecosystem, Population Dynamics, Sweden, Coleoptera, Quercus
- Abstract
Osmoderma eremita is a species of beetle that inhabits hollows in ancient trees, which is a habitat that has decreased significantly during the last century. In southeastern Sweden, we studied the metapopulation dynamics of this beetle over a 25 year period, using capture-mark-recapture. The metapopulation size had been rather stable over time, but in most of the individual trees there had been a positive or negative trend in population development. The probability of colonisation was higher in well-connected trees with characteristics reflecting earlier successional stages, and the probability of extinction higher in trees with larger diameter (i.e. in later successional stages), which is expected from a habitat-tracking metapopulation. The annual tree mortality and fall rates (1.1% and 0.4%, respectively) are lower than the colonisation and extinction rates (5-7%), indicating that some of the metapopulation dynamics are due to the habitat dynamics, but many colonisations and extinctions take place for other reasons, such as stochastic events in small populations. The studied metapopulation occurs in an area with a high density of hollow oaks and where the oak pastures are still managed by grazing. In stands with fewer than ten suitable trees, the long-term extinction risk may be considerable, since only a small proportion of all hollow trees harbours large populations, and the population size in trees may change considerably during a decade.
- Published
- 2020
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43. New insights for mesospheric OH: multi-quantum vibrational relaxation as a driver for non-local thermodynamic equilibrium.
- Author
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Kalogerakis KS, Matsiev D, Cosby PC, Dodd JA, Falcinelli S, Hedin J, Kutepov AA, Noll S, Panka PA, Romanescu C, and Thiebaud JE
- Abstract
The question of whether mesospheric OH( υ ) rotational population distributions are in equilibrium with the local kinetic temperature has been debated over several decades. Despite several indications for the existence of non-equilibrium effects, the general consensus has been that emissions originating from low rotational levels are thermalized. Sky spectra simultaneously observing several vibrational levels demonstrated reproducible trends in the extracted OH( υ ) rotational temperatures as a function of vibrational excitation. Laboratory experiments provided information on rotational energy transfer and direct evidence for fast multi-quantum OH(high- υ ) vibrational relaxation by O atoms. We examine the relationship of the new relaxation pathways with the behavior exhibited by OH( υ ) rotational population distributions. Rapid OH(high- υ ) + O multi-quantum vibrational relaxation connects high and low vibrational levels and enhances the hot tail of the OH(low- υ ) rotational distributions. The effective rotational temperatures of mesospheric OH( υ ) are found to deviate from local thermodynamic equilibrium for all observed vibrational levels., Competing Interests: Competing interests. The authors declare that they have no conflict of interest.
- Published
- 2018
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44. Self-Assembly of Recombinant Silk as a Strategy for Chemical-Free Formation of Bioactive Coatings: A Real-Time Study.
- Author
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Nilebäck L, Hedin J, Widhe M, Floderus LS, Krona A, Bysell H, and Hedhammar M
- Subjects
- Animals, Anti-Infective Agents pharmacology, Bacterial Load, Cell Adhesion drug effects, Cells, Cultured, Endothelial Cells drug effects, Endothelial Cells metabolism, Humans, Spiders, Staphylococcus aureus drug effects, Coated Materials, Biocompatible chemistry, Recombinant Proteins chemistry, Silk chemistry
- Abstract
Functionalization of biomaterials with biologically active peptides can improve their performance after implantation. By genetic fusion to self-assembling proteins, the functional peptides can easily be presented on different physical formats. Herein, a chemical-free coating method based on self-assembly of the recombinant spider silk protein 4RepCT is described and used to prepare functional coatings on various biomaterial surfaces. The silk assembly was studied in real-time, revealing the occurrence of continuous assembly of silk proteins onto surfaces and the formation of nanofibrillar structures. The adsorbed amounts and viscoelastic properties were evaluated, and the coatings were shown to be stable against wash with hydrogen chloride, sodium hydroxide, and ethanol. Titanium, stainless steel, and hydroxyapatite were coated with silk fused to an antimicrobial peptide or a motif from fibronectin. Human primary cells cultured on the functional silk coatings show good cell viability and proliferation, implying the potential to improve implant performance and acceptance by the body.
- Published
- 2017
- Full Text
- View/download PDF
45. Facilitated assessment of tissue loss following traumatic brain injury.
- Author
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Hånell A, Hedin J, Clausen F, and Marklund N
- Abstract
All experimental models of traumatic brain injury (TBI) result in a progressive loss of brain tissue. The extent of tissue loss reflects the injury severity and can be measured to evaluate the potential neuroprotective effect of experimental treatments. Quantitation of tissue volumes is commonly performed using evenly spaced brain sections stained using routine histochemical methods and digitally captured. The brain tissue areas are then measured and the corresponding volumes are calculated using the distance between the sections. Measurements of areas are usually performed using a general purpose image analysis software and the results are then transferred to another program for volume calculations. To facilitate the measurement of brain tissue loss we developed novel algorithms which automatically separate the areas of brain tissue from the surrounding image background and identify the ventricles. We implemented these new algorithms by creating a new computer program (SectionToVolume) which also has functions for image organization, image adjustments and volume calculations. We analyzed brain sections from mice subjected to severe focal TBI using both SectionToVolume and ImageJ, a commonly used image analysis program. The volume measurements made by the two programs were highly correlated and analysis using SectionToVolume required considerably less time. The inter-rater reliability was high. Given the extensive use of brain tissue loss measurements in TBI research, SectionToVolume will likely be a useful tool for TBI research. We therefore provide both the source code and the program as attachments to this article.
- Published
- 2012
- Full Text
- View/download PDF
46. Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.
- Author
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Clausen F, Hånell A, Israelsson C, Hedin J, Ebendal T, Mir AK, Gram H, and Marklund N
- Subjects
- Animals, Antibodies therapeutic use, Behavior, Animal physiology, Brain Edema physiopathology, Brain Injuries physiopathology, Chemokines genetics, Chemokines metabolism, Cognition Disorders physiopathology, Disease Models, Animal, Glial Fibrillary Acidic Protein genetics, Glial Fibrillary Acidic Protein metabolism, Humans, Interleukin-6 genetics, Interleukin-6 metabolism, Learning physiology, Male, Memory physiology, Mice, Mice, Inbred C57BL, Microglia cytology, Microglia metabolism, Neuropsychological Tests, Treatment Outcome, Brain Edema etiology, Brain Edema pathology, Brain Injuries complications, Brain Injuries pathology, Cognition Disorders etiology, Interleukin-1beta metabolism
- Abstract
Increasing evidence suggests that interleukin-1β (IL-1β) is a key mediator of the inflammatory response following traumatic brain injury (TBI). Recently, we showed that intracerebroventricular administration of an IL-1β-neutralizing antibody was neuroprotective following TBI in mice. In the present study, an anti-IL-1β antibody or control antibody was administered intraperitoneally following controlled cortical injury (CCI) TBI or sham injury in 105 mice and we extended our histological, immunological and behavioral analysis. First, we demonstrated that the treatment antibody reached target brain regions of brain-injured animals in high concentrations (> 11 nm) remaining up to 8 days post-TBI. At 48 h post-injury, the anti-IL-1β treatment attenuated the TBI-induced hemispheric edema (P < 0.05) but not the memory deficits evaluated using the Morris water maze (MWM). Neutralization of IL-1β did not influence the TBI-induced increases (P < 0.05) in the gene expression of the Ccl3 and Ccr2 chemokines, IL-6 or Gfap. Up to 20 days post-injury, neutralization of IL-1β was associated with improved visuospatial learning in the MWM, reduced loss of hemispheric tissue and attenuation of the microglial activation caused by TBI (P < 0.05). Motor function using the rotarod and cylinder tests was not affected by the anti-IL-1β treatment. Our results suggest an important negative role for IL-1β in TBI. The improved histological and behavioral outcome following anti-IL-1β treatment also implies that further exploration of IL-1β-neutralizing compounds as a treatment option for TBI patients is warranted., (© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.)
- Published
- 2011
- Full Text
- View/download PDF
47. Coordination of imidazoles by Cu(II) and Zn(II) as studied by NMR relaxometry, EPR, far-FTIR vibrational spectroscopy and ab initio calculations: effect of methyl substitution.
- Author
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Andersson M, Hedin J, Johansson P, Nordström J, and Nydén M
- Abstract
Synthetic imidazole ligands are typically substituted at the N(1) ((1)-Im) position while natural imidazole ligands are substituted at the C(4) ((4)-Im) position. To outline the difference in coordination properties, the methyl-substituted imidazoles Me(4)-Im and Me(1)-Im were complexed with CuCl(2) and ZnCl(2) and investigated by NMR relaxometry, electron paramagnetic resonance, far-Fourier transform IR vibrational spectroscopy, and ab initio calculations. Me(4)-Im, Me(1)-Im, and Im in excess form the usual tetragonal D(4h) [CuL(4)X(2)] complexes with CuCl(2) whereas the methylated imidazoles form pseudotetrahedral C(2v) complexes instead of the usual octahedral O(h) [ZnIm(6)](2+) complex. All imidazoles display a high degree of covalence in the M-L σ- and π-bonds and the π-interaction strength affects the relative energies of complexation. Opportunities to tailor complexes by the chemical properties of the substituents are envisaged due to the role of the inductive and hyperconjugative effects, rather than position.
- Published
- 2010
- Full Text
- View/download PDF
48. Bi-layer formation of imidazole-modified ethyl(hydroxyethyl)cellulose at a hydrophobic surface as monitored by QCM-D.
- Author
-
Hedin J, Isaksson D, Andersson M, and Nydén M
- Abstract
The adsorption behaviour of ethyl(hydroxyethyl)cellulose chemically modified with imidazole (Im-EHEC) at hydrophobic surfaces has been studied with QCM-D. The very slow adsorption isotherm was due to a continuous polymer film reconfiguration and exchange of different sized polymers. The thickness of the film was about 30 nm. The polymers adsorbed Cu(2+) ions into the film from a CuCl(2) solution and a bi-layer was formed when Im-EHEC was added a second time. The second polymer film was only 7 nm thick but highly viscoelastic. After rinsing with water the metal ions was flushed away and the second Im-EHEC layer was released. The imidazole modification of EHEC enables interaction with transition metal ions and opens up for new applications for cellulose based materials.
- Published
- 2009
- Full Text
- View/download PDF
49. Adsorption behavior and cross-linking of EHEC and HM-EHEC at hydrophilic and hydrophobic modified surfaces monitored by SPR and QCM-D.
- Author
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Hedin J, Löfroth JE, and Nydén M
- Abstract
The adsorption behavior of ethyl(hydroxyethyl) cellulose EHEC and hydrophobically modified EHEC (HM-EHEC) at hydrophilic and hydrophobic surfaces has been studied using surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D) methods. The adsorbed amounts measured with the different methods were different due to large amounts of water in the films. The slow adsorption process made it reasonable to assume a continuous polymer reconfiguration process at the surface. This was mostly seen for HM-EHEC at the hydrophobic surface, where a more flexible structure was adopted during the adsorption process. A cross-linking agent was seen to truly interpolymer cross-link EHEC at the hydrophilic surface and HM-EHEC at the hydrophobic surface. For EHEC at a hydrophobic surface and for HM-EHEC at a hydrophilic surface, the polymers adsorbed in an individually phase-separated manner, making an interpolymer cross-linking reaction unsuccessful.
- Published
- 2007
- Full Text
- View/download PDF
50. Attraction of the larval predator Elater ferrugineus to the sex pheromone of its prey, Osmoderma eremita, and its implication for conservation biology.
- Author
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Svensson GP, Larsson MC, and Hedin J
- Subjects
- Animals, Environmental Monitoring, Female, Larva growth & development, Male, Odorants, Population Dynamics, Predatory Behavior, Trees, Coleoptera physiology, Conservation of Natural Resources, Sex Attractants pharmacology
- Abstract
Elater ferrugineus is a threatened click beetle inhabiting old hollow trees. Its larvae consume larvae of other saproxylic insects including the threatened scarab beetle Osmoderma eremita. Recently, (R)-(+)-gamma-decalactone was identified as a male-produced sex pheromone of O. eremita. Here we present evidence that E. ferrugineus adults use this odor as a kairomone for location of their prey. In field trapping experiments, significantly more trapping events of E. ferrugineus beetles were observed in Lindgren funnel traps baited with (R)-(+)-gamma-decalactone than in control traps (20 vs. 1, respectively). Analyses of headspace collections from E. ferrugineus beetles indicate that the predator itself does not produce the substance. Both sexes were attracted to the prey pheromone. suggesting that E. ferrugineus males use the odor as an indirect cue for location of mates or of the tree hollows, which make up their habitat. When compared to pitfall traps, the Lindgren system was significantly more effective in trapping E. ferragineus, and no difference could be established for O. eremita, showing the high potential to use odor-based systems to catch both species. We suggest that (R)-(+)-gamma-decalactone could be used as a master signal in monitoring programs for these vulnerable beetle species. which are both regarded as indicators of the associated insect fauna of the threatened habitat of old hollow trees.
- Published
- 2004
- Full Text
- View/download PDF
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