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465 results on '"Hedderich, Jürgen"'

5. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2020
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16. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2018
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18. Einführung

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2018
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22. Einführung

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2016
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29. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2016
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36. The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma

Author

Quabius, Elgar S., Görögh, Tibor, Fischer, Gerrit S., Hoffmann, Anna S., Gebhard, Maximilian, Evert, Matthias, Beule, Achim, Maune, Steffen, Knecht, Rainald, Óvári, Attila, Durisin, Martin, Hoppe, Florian, Röcken, Christoph, Hedderich, Jürgen, Ambrosch, Petra, and Hoffmann, Markus

Published
2015
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45. Exercise oscillatory ventilation in patients with advanced heart failure with and without left ventricular assist device.

Author

Wernhart, Simon, Papathanasiou, Maria, Jakstaite, Aiste, Hoffmann, Julia, Schmack, Bastian, Hedderich, Jürgen, Ruhparwar, Arjang, Rassaf, Tienush, and Luedike, Peter

Subjects
HEART assist devices, HEART failure patients, EXERCISE tests, NEUROENDOCRINE cells, AORTIC valve, AEROBIC capacity, CARDIAC catheterization, TRANSCRANIAL magnetic stimulation
Abstract

Background: Exercise oscillatory ventilation (EOV), indicating pathological fluctuations on pulmonary arterial pressure, is associated with mortality in patients with heart failure (HF). Whether left ventricular assist device (LVAD)‐induced ventricular unloading can reverse EOV and may prevent short‐term rehospitalization has not been investigated. Methods: We performed a retrospective single‐center in‐ and outpatient analysis of patients with (n = 20, LVAD) and without (n = 27, HF) circulatory support and reduced ejection fraction (EF, 22.8 ± 7.9%). The association of cardiopulmonary exercise testing (CPET) variables and 3 months‐rehospitalization (3MR) as a primary outcome was analyzed. Furthermore, CPET variables were compared regarding the presence of EOV (+/−). Results: Lower VO2peak (11.6 ± 4.9 ml/kg/min vs. 14.4 ± 4.3 ml/kg/min, p = 0.039), lower increase of PETCO2 (CI = 0.049–1.127; p = 0.068), and higher VE/VCO2 (43.8 ± 9.5 vs. 38.3 ± 10.6; p = 0.069) were associated with 3MR. Flattening of O2 pulse (CI = 0.139–2.379; p = 0.487) had no impact on 3MR. EOV was present in 59.5% (n = 28/47) of patients, without a significant difference between LVAD and HF patients (p = 0.959). Patients with HF/EOV+ demonstrated significantly lower VO2peak compared with HF/EOV− (p = 0.039). LVAD/EOV+ displayed significantly lower EF (p = 0.004) and fewer aortic valve opening than LVAD/EOV− (p = 0.027). Conclusions: Lower VO2peak, but not EOV, was associated with 3MR. EOV occurred at a similar rate in LVAD and HF patients, which may illustrate insufficient unloading during exercise in chronic LVAD therapy and may contribute to the limited exercise capacity following LVAD implantation. Simultaneous CPET and right heart catheterization studies are needed to elucidate whether EOV may serve as a non‐invasive predictor of insufficient LV unloading necessitating LVAD reprograming. [ABSTRACT FROM AUTHOR]

Published
2023
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