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2. Safety and effectiveness of the LVIS and LVIS Jr devices for the treatment of intracranial aneurysms: Final results of the LEPI multicenter cohort study

Author

Forestier, Géraud, Piotin, Michel, Chau, Yves, Derelle, Anne-Laure, Brunel, Hervé, Aggour, Mohammed, Saleme, Suzana, Levrier, Olivier, Pierot, Laurent, Barreau, Xavier, Boubagra, Kamel, Janot, Kévin, Barbier, Charlotte, Clarençon, Frédéric, Chabert, Emmanuel, SPELLE, Laurent, Arteaga, Charles, Consoli, Arturo, Machi, Paolo, Blanc, Raphaël, Rodesch, Georges, Cortese, Jonathan, Sourour, Nader, Herbreteau, Denis, Heck, Olivier, Soize, Sébastien, Marnat, Gaultier, Rouchaud, Aymeric, Anxionnat, René, Sedat, Jacques, and Mounayer, Charbel

Published
2024
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3. “National survey for preliminary evaluation of neuroradiological protocols in patients with infective endocarditis”

Author

Picherit, Alexandre, Kerleroux, Dr Basile, Forestier, Géraud, Marnat, Gaultier, Boutet, Claire, Ifergan, Héloïse, Hak, Jean-François, Guedon, Alexis, Lecler, Augustin, Heck, Olivier, Paya, Christophe, Burel, Julien, Masy, Matthieu, Lauvin, Marie-Agnès, Rodallec, Mathieu, Eugene, Francois, Zhu, François, Pop, Raoul, Boucebci, Samy, Soize, Sébastien, Boulouis, Grégoire, and Bourcier, Romain

Published
2023
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4. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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6. Sub-acute and Chronic Ischemic Stroke Lesion MRI Segmentation

Author

Doyle, Senan, Forbes, Florence, Jaillard, Assia, Heck, Olivier, Detante, Olivier, Dojat, Michel, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Crimi, Alessandro, editor, Bakas, Spyridon, editor, Kuijf, Hugo, editor, Menze, Bjoern, editor, and Reyes, Mauricio, editor

Published
2018
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8. Safety and effectiveness of the LVIS and LVIS Jr devices for the treatment of intracranial aneurysms: Final results of the LEPI multicenter cohort study

Author

Forestier, Géraud, primary, Piotin, Michel, additional, Chau, Yves, additional, Derelle, Anne-Laure, additional, Brunel, Hervé, additional, Aggour, Mohammed, additional, Saleme, Suzana, additional, Levrier, Olivier, additional, Pierot, Laurent, additional, Barreau, Xavier, additional, Boubagra, Kamel, additional, Janot, Kévin, additional, Barbier, Charlotte, additional, Clarençon, Frédéric, additional, Chabert, Emmanuel, additional, SPELLE, Laurent, additional, Arteaga, Charles, additional, Consoli, Arturo, additional, Machi, Paolo, additional, Blanc, Raphaël, additional, Rodesch, Georges, additional, Cortese, Jonathan, additional, Sourour, Nader, additional, Herbreteau, Denis, additional, Heck, Olivier, additional, Soize, Sébastien, additional, Marnat, Gaultier, additional, Rouchaud, Aymeric, additional, Anxionnat, René, additional, Sedat, Jacques, additional, and Mounayer, Charbel, additional

Published
2023
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9. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial

Author

Poli, Sven, primary, Mbroh, Joshua, additional, Baron, Jean-Claude, additional, Singhal, Aneesh B, additional, Strbian, Daniel, additional, Molina, Carlos, additional, Lemmens, Robin, additional, Turc, Guillaume, additional, Mikulik, Robert, additional, Michel, Patrik, additional, Tatlisumak, Turgut, additional, Audebert, Heinrich J, additional, Dichgans, Martin, additional, Veltkamp, Roland, additional, Hüsing, Johannes, additional, Graessner, Holm, additional, Fiehler, Jens, additional, Montaner, Joan, additional, Adeyemi, Adedolapo Kamaldeen, additional, Althaus, Katharina, additional, Arenillas, Juan F, additional, Bender, Benjamin, additional, Benedikt, Frank, additional, Broocks, Gabriel, additional, Burghaus, Ina, additional, Cardona, Pere, additional, Deb-Chatterji, Milani, additional, Cviková, Martina, additional, Defreyne, Luc, additional, De Herdt, Veerle, additional, Detante, Olivier, additional, Ernemann, Ulrike, additional, Flottmann, Fabian, additional, García Guillamón, Lídia, additional, Glauch, Monika, additional, Gomez-Exposito, Alexandra, additional, Gory, Benjamin, additional, Sylvie Grand, Sylvie, additional, Haršány, Michal, additional, Hauser, Till Karsten, additional, Heck, Olivier, additional, Hemelsoet, Dimitri, additional, Hennersdorf, Florian, additional, Hoppe, Julia, additional, Kalmbach, Pia, additional, Kellert, Lars, additional, Köhrmann, Martin, additional, Kowarik, Markus, additional, Lara-Rodríguez, Blanca, additional, Legris, Loic, additional, Lindig, Tobias, additional, Luntz, Steffen, additional, Lusk, Jay, additional, Mac Grory, Brian, additional, Manger, Andreas, additional, Martinez-Majander, Nicolas, additional, Mengel, Annerose, additional, Meyne, Johannes, additional, Müller, Susanne, additional, Mundiyanapurath, Sibu, additional, Naggara, Olivier, additional, Nedeltchev, Krassen, additional, Nguyen, Thanh N, additional, Nilsson, Maike A, additional, Obadia, Michael, additional, Poli, Khouloud, additional, Purrucker, Jan C, additional, Räty, Silja, additional, Richard, Sebastien, additional, Richter, Hardy, additional, Schilte, Clotilde, additional, Schlemm, Eckhard, additional, Stöhr, Linda, additional, Stolte, Benjamin, additional, Sykora, Marek, additional, Thomalla, Götz, additional, Tomppo, Liisa, additional, van Horn, Noel, additional, Zeller, Julia, additional, Ziemann, Ulf, additional, Zuern, Christine S, additional, Härtig, Florian, additional, Tuennerhoff, Johannes, additional, Hassen, Wagih Ben, additional, Benz, Thorsten, additional, Brandhorst, Ansgar, additional, Cendrero, Judith, additional, Cheng, Bastian, additional, Cuisenier, Pauline, additional, Favre-Wiki, Isabelle, additional, Garambois, Katia, additional, Jensen, Märit, additional, Guillen, Ana Nuñez, additional, Merchan, Andres Paipa, additional, Pala, Elena, additional, Pancorbo, Olalla, additional, Morenilla, Ana Penalba, additional, Garcia, Helena Quesada, additional, Richter, Vivien, additional, Schell, Maximilian, additional, Schirmer, Andrea, additional, Sibolt, Gerli, additional, Stoop, Wendy, additional, Wischmann, Johannes, additional, and Zanolini, Umberto, additional

Published
2023
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10. Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke

Author

Garambois, K., Barbieux-Guillot, M., Favre-Wiki, I., Grand, S., Le Bas, J.F., Moisan, A., Richard, M.J., De Fraipont, F., Gere, J., Marcel, S., Vadot, W., Rodier, G., Perennou, D., Chrispin, A., Davoine, P., Naegele, B., Antoine, P., Tropres, I., Renard, F., Hannanu, Firdaus Fabrice, Zeffiro, Thomas A., Lamalle, Laurent, Heck, Olivier, Renard, Félix, Thuriot, Antoine, Krainik, Alexandre, Hommel, Marc, Detante, Olivier, and Jaillard, Assia

Published
2017
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11. Assessment of Tissue Injury in Severe Brain Trauma

Author

Maggia, Christophe, Doyle, Senan, Forbes, Florence, Heck, Olivier, Troprès, Irène, Berthet, Corentin, Teyssier, Yann, Velly, Lionel, Payen, Jean-François, Dojat, Michel, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Crimi, Alessandro, editor, Menze, Bjoern, editor, Maier, Oskar, editor, Reyes, Mauricio, editor, and Handels, Heinz, editor

Published
2016
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13. Influence de la thrombolyse intraveineuse chez les patients traites par thrombectomie mecanique pour une occlusion M2: une analyse du registre etis

Author

Floch, Agathe Le, primary, Clarencon, Frederic, additional, Rouchaud, Aymeric, additional, Khyeng, Maeva, additional, Labreuche, Julien, additional, Sibon, Igor, additional, Boulouis, Gregoire, additional, Gory, Benjamin, additional, Richard, Sebastien, additional, Caroff, Jildaz, additional, Blanc, Raphael, additional, Seners, Pierre, additional, Eker, Omer, additional, Cho, Tae-Hee, additional, Consoli, Arturo, additional, Bourcier, Romain, additional, Guillon, Benoit, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Denier, Christian, additional, Eugene, Francois, additional, Vannier, Stephanie, additional, Gentric, Jean-Christophe, additional, Gauberti, Maxime, additional, Nagarra, Olivier, additional, Rosso, Charlotte, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Cognard, Christophe, additional, Albucher, Jean-Francois, additional, Timsit, Serge, additional, Bourdain, Frederic, additional, Bras, Anthony Le, additional, Richter, Sebastian, additional, Moulin, Solene, additional, Pop, Raoul, additional, Heck, Olivier, additional, Moreno, Ricardo, additional, L'Allinec, Vincent, additional, Lapergue, Bertrand, additional, and Marnat, Gaultier, additional

Published
2023
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14. Influence of prior intravenous thrombolysis in patients treated with mechanical thrombectomy for M2 occlusions: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) registry

Author

Le Floch, Agathe, primary, Clarençon, Frédéric, additional, Rouchaud, Aymeric, additional, Kyheng, Maeva, additional, Labreuche, Julien, additional, Sibon, Igor, additional, Boulouis, Gregoire, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Caroff, Jildaz, additional, Blanc, Raphaël, additional, Seners, Pierre, additional, Eker, Omer F, additional, Cho, Tae-Hee, additional, Consoli, Arturo, additional, Bourcier, Romain, additional, guillon, benoit, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Denier, Christian, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Gentric, Jean-Christophe, additional, Gauberti, Maxime, additional, Naggara, Olivier, additional, Rosso, Charlotte, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Cognard, Christophe, additional, Albucher, Jean François, additional, Timsit, Serge, additional, Bourdain, Frederic, additional, Le Bras, Anthony, additional, Richter, Sebastian, additional, Moulin, Solène, additional, Pop, Raoul, additional, Heck, Olivier, additional, Moreno, Ricardo, additional, L'Allinec, Vincent, additional, Lapergue, Bertrand, additional, and Marnat, Gaultier, additional

Published
2022
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17. Antithrombotic therapies for neurointerventional surgery: a 2021 French comprehensive national survey

Author

Caroff, Jildaz, primary, Aubert, Laurent, additional, Lavenu-Bombled, Cécile, additional, Figueiredo, Samy, additional, Habchi, Kamelia, additional, Cortese, Jonathan, additional, Eugene, Francois, additional, Ognard, Julien, additional, Tahon, Florence, additional, Forestier, Géraud, additional, Ifergan, Heloise, additional, Zhu, François, additional, Hak, Jean-Francois, additional, Reyre, Anthony, additional, Laubacher, Morgane, additional, Traore, Abdoulaye, additional, Desilles, Jean Philippe, additional, Derraz, Imad, additional, Moreno, Ricardo, additional, Bintner, Marc, additional, Charbonnier, Guillaume, additional, Le Bras, Anthony, additional, Veunac, Louis, additional, Gariel, Florent, additional, Redjem, Hocine, additional, Sedat, Jacques, additional, Tessier, Guillaume, additional, Dumas, Victor, additional, Gauberti, Maxime, additional, Chivot, Cyril, additional, Consoli, Arturo, additional, Bricout, Nicolas, additional, Tuilier, Titien, additional, Guedon, Alexis, additional, Pop, Raoul, additional, Thouant, Pierre, additional, Bellanger, Guillaume, additional, Zannoni, Riccardo, additional, Soize, Sebastien, additional, Richter, Johann Sebastian, additional, Heck, Olivier, additional, Mihalea, Cristian, additional, Burel, Julien, additional, Girot, Jean-Baptiste, additional, Shotar, Eimad, additional, Gazzola, Sebastian, additional, Boulouis, Gregoire, additional, and Kerleroux, Basile, additional

Published
2022
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19. Assessment of Tissue Injury in Severe Brain Trauma

Author

Maggia, Christophe, primary, Doyle, Senan, additional, Forbes, Florence, additional, Heck, Olivier, additional, Troprès, Irène, additional, Berthet, Corentin, additional, Teyssier, Yann, additional, Velly, Lionel, additional, Payen, Jean-François, additional, and Dojat, Michel, additional

Published
2016
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20. Influence of prior intravenous thrombolysis in patients treated with mechanical thrombectomy for M2 occlusions: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) registry

Author

Le Floch, Agathe, Clarencon, Frédéric, Rouchaud, Aymeric, Kyheng, Maeva, Labreuche, Julien, Sibon, Igor, Boulouis, Gregoire, Gory, Benjamin, Richard, Sébastien, Caroff, Jildaz, Blanc, Raphae¨l, Seners, Pierre, Eker, Omer F, Cho, Tae-Hee, Consoli, Arturo, Bourcier, Romain, guillon, benoit, Dargazanli, Cyril, Arquizan, Caroline, Denier, Christian, Eugene, Francois, Vannier, Stephane, Gentric, Jean-Christophe, Gauberti, Maxime, Naggara, Olivier, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Cognard, Christophe, Albucher, Jean Francois, Timsit, Serge, Bourdain, Frederic, Le Bras, Anthony, Richter, Sebastian, Moulin, Solène, Pop, Raoul, Heck, Olivier, Moreno, Ricardo, L'Allinec, Vincent, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

BackgroundIntravenous thrombolysis (IVT) for patients treated with mechanical thrombectomy (MT) for proximal occlusions has recently been questioned through randomized trials. However, few patients with M2 occlusions were included. We investigated the influence of prior IVT for patients presenting M2 occlusions treated with MT in comparison with MT alone.MethodsWe conducted a retrospective analysis of the Endovascular Treatment in Ischemic Stroke (ETIS) registry, a multicenter observational study. Data from consecutive patients treated with MT for M2 occlusions between January 2015 and January 2022 at 26 comprehensive stroke centers were analyzed. The primary endpoint was 90-day modified Rankin Scale score of 0–2. Outcomes were compared using propensity score approaches. We also performed sensitivity analysis in relevant subgroups of patients.ResultsAmong 1132 patients with M2 occlusions treated with MT, 570 received prior IVT. The two groups were comparable after propensity analysis. The rate of favorable functional outcome was significantly higher in the IVT+MT group compared with the MT alone group (59.8% vs 44.7%; adjusted OR 1.38, 95% CI 1.10 to 1.75, P=0.008). Hemorrhagic and procedural complications were similar in both groups. In sensitivity analysis excluding patients with anticoagulation treatment, favorable recanalization was more frequent in the IVT+MT group (OR 1.37, 95% CI 1.11 to 1.70, P=0.004).ConclusionsIn cases of M2 occlusions, prior IVT combined with MT resulted in better functional outcome than MT alone, without increasing the rate of hemorrhagic or procedural complications. These results suggest the benefit of IVT in patients undergoing MT for M2 occlusions.

Published
2023
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21. Antithrombotic therapies for neurointerventional surgery: a 2021 French comprehensive national survey

Author

Caroff, Jildaz, Aubert, Laurent, Lavenu-Bombled, Cécile, Figueiredo, Samy, Habchi, Kamelia, Cortese, Jonathan, Eugene, Francois, Ognard, Julien, Tahon, Florence, Forestier, Géraud, Ifergan, Heloise, Zhu, Francois, Hak, Jean-Francois, Reyre, Anthony, Laubacher, Morgane, Traore, Abdoulaye, Desilles, Jean Philippe, Derraz, Imad, Moreno, Ricardo, Bintner, Marc, Charbonnier, Guillaume, Le Bras, Anthony, Veunac, Louis, Gariel, Florent, Redjem, Hocine, Sedat, Jacques, Tessier, Guillaume, Dumas, Victor, Gauberti, Maxime, Chivot, Cyril, Consoli, Arturo, Bricout, Nicolas, Tuilier, Titien, Guedon, Alexis, Pop, Raoul, Thouant, Pierre, Bellanger, Guillaume, Zannoni, Riccardo, Soize, Sebastien, Richter, Johann Sebastian, Heck, Olivier, Mihalea, Cristian, Burel, Julien, Girot, Jean-Baptiste, Shotar, Eimad, Gazzola, Sebastian, Boulouis, Gregoire, and Kerleroux, Basile

Abstract

BackgroundNeurointerventionists lack guidelines for the use of antithrombotic therapies in their clinical practice; consequently, there is likely to be significant heterogeneity in antithrombotic use between centers. Through a nationwide survey, we aimed to obtain an exhaustive cross-sectional overview of antithrombotic use in neurointerventional procedures in France.MethodsIn April 2021, French neurointerventional surgery centers were invited to participate in a nationwide 51-question survey disseminated through an active trainee-led research collaborative network (the JENI-RC).ResultsAll 40 centers answered the survey. Fifty-one percent of centers reported using ticagrelor and 43% used clopidogrel as premedication before intracranial stenting. For flow diversion treatment, dual antiplatelet therapy was maintained for 3 or 6 months in 39% and 53% of centers, respectively, and aspirin was prescribed for 12 months or more than 12 months in 63% and 26% of centers, respectively. For unruptured aneurysms, the most common heparin bolus dose was 50 IU/kg (59%), and only 35% of centers monitored heparin activity for dose adjustment. Tirofiban was used in 64% of centers to treat thromboembolic complications. Fifteen percent of these comprehensive stroke centers reported using tenecteplase to treat acute ischemic strokes. Cangrelor appeared as an emergent drug in specific indications.ConclusionThis nationwide survey highlights the important heterogeneity in clinical practices across centers. There is a pressing need for trials and guidelines to further evaluate and harmonize antithrombotic regimens in the neurointerventional field.

Published
2023
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24. Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke

Author

Hannanu, Firdaus Fabrice, primary, Zeffiro, Thomas A., additional, Lamalle, Laurent, additional, Heck, Olivier, additional, Renard, Félix, additional, Thuriot, Antoine, additional, Krainik, Alexandre, additional, Hommel, Marc, additional, Detante, Olivier, additional, Jaillard, Assia, additional, Garambois, K., additional, Barbieux-Guillot, M., additional, Favre-Wiki, I., additional, Grand, S., additional, Le Bas, J.F., additional, Moisan, A., additional, Richard, M.J., additional, De Fraipont, F., additional, Gere, J., additional, Marcel, S., additional, Vadot, W., additional, Rodier, G., additional, Perennou, D., additional, Chrispin, A., additional, Davoine, P., additional, Naegele, B., additional, Antoine, P., additional, Tropres, I., additional, and Renard, F., additional

Published
2017
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26. Low-flow vascular malformation

Author

Heck, Olivier, primary, Krainik, Alexandre, additional, Boubagra, Kamel, additional, Tahon, Florence, additional, Attye, Arnaud, additional, Le Bas, Jean François, additional, Boutonnat, Jean, additional, and Grand, Sylvie, additional

Published
2014
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27. Rupture of lenticulostriate artery aneurysms

Author

Heck, Olivier, primary, Anxionnat, René, additional, Lacour, Jean-Christophe, additional, Derelle, Anne-Laure, additional, Ducrocq, Xavier, additional, Richard, Sébastien, additional, and Bracard, Serge, additional

Published
2014
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28. Thrombolysis and thrombectomy for stroke in octogenarians and nonagenarians: a regional observational study

Author

Michelard, Manon, Detante, Olivier, Heck, Olivier, Marcel, Sébastien, Vadot, Wilfried, Gavazzi, Gaetan, and Papassin, Jérémie

Abstract

Introduction: Elderly patients are a growing population in stroke units, characterized by higher frailty, but underrepresented in clinical trials about acute care. We investigated efficacy of intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) in elderlies in current practice.

Published
2023
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31. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial.

Author

Poli S, Mbroh J, Baron JC, Singhal AB, Strbian D, Molina C, Lemmens R, Turc G, Mikulik R, Michel P, Tatlisumak T, Audebert HJ, Dichgans M, Veltkamp R, Hüsing J, Graessner H, Fiehler J, Montaner J, Adeyemi AK, Althaus K, Arenillas JF, Bender B, Benedikt F, Broocks G, Burghaus I, Cardona P, Deb-Chatterji M, Cviková M, Defreyne L, De Herdt V, Detante O, Ernemann U, Flottmann F, García Guillamón L, Glauch M, Gomez-Exposito A, Gory B, Sylvie Grand S, Haršány M, Hauser TK, Heck O, Hemelsoet D, Hennersdorf F, Hoppe J, Kalmbach P, Kellert L, Köhrmann M, Kowarik M, Lara-Rodríguez B, Legris L, Lindig T, Luntz S, Lusk J, Mac Grory B, Manger A, Martinez-Majander N, Mengel A, Meyne J, Müller S, Mundiyanapurath S, Naggara O, Nedeltchev K, Nguyen TN, Nilsson MA, Obadia M, Poli K, Purrucker JC, Räty S, Richard S, Richter H, Schilte C, Schlemm E, Stöhr L, Stolte B, Sykora M, Thomalla G, Tomppo L, van Horn N, Zeller J, Ziemann U, Zuern CS, Härtig F, and Tuennerhoff J

Subjects
Humans, Multicenter Studies as Topic, Oxygen therapeutic use, Quality of Life, Thrombectomy methods, Treatment Outcome, Clinical Trials, Phase II as Topic, Brain Ischemia complications, Endovascular Procedures methods, Ischemic Stroke complications, Ischemic Stroke diagnosis
Abstract

Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs., Aims: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion., Methods and Design: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial., Study Outcomes: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted., Sample Size: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation., Discussion: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia., Trial Registrations: ClinicalTrials.gov: NCT03500939; EudraCT: 2017-001355-31., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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