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671 results on '"Hecht, Jonathan L."'

2. CCNE1 and survival of patients with tubo‐ovarian high‐grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

Author

Kang, Eun‐Young, Weir, Ashley, Meagher, Nicola S, Farrington, Kyo, Nelson, Gregg S, Ghatage, Prafull, Lee, Cheng‐Han, Riggan, Marjorie J, Bolithon, Adelyn, Popovic, Gordana, Leung, Betty, Tang, Katrina, Lambie, Neil, Millstein, Joshua, Alsop, Jennifer, Anglesio, Michael S, Ataseven, Beyhan, Barlow, Ellen, Beckmann, Matthias W, Berger, Jessica, Bisinotto, Christiani, Bösmüller, Hans, Boros, Jessica, Brand, Alison H, Brooks‐Wilson, Angela, Brucker, Sara Y, Carney, Michael E, Casablanca, Yovanni, Cazorla‐Jiménez, Alicia, Cohen, Paul A, Conrads, Thomas P, Cook, Linda S, Coulson, Penny, Courtney‐Brooks, Madeleine, Cramer, Daniel W, Crowe, Philip, Cunningham, Julie M, Cybulski, Cezary, Darcy, Kathleen M, El‐Bahrawy, Mona A, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fereday, Sian, Fischer, Anna, García, María J, Gayther, Simon A, Gentry‐Maharaj, Aleksandra, Gilks, C Blake, Group, AOCS, Grube, Marcel, Harnett, Paul R, Harrington, Shariska Petersen, Harter, Philipp, Hartmann, Arndt, Hecht, Jonathan L, Heikaus, Sebastian, Hein, Alexander, Heitz, Florian, Hendley, Joy, Hernandez, Brenda Y, Polo, Susanna Hernando, Heublein, Sabine, Hirasawa, Akira, Høgdall, Estrid, Høgdall, Claus K, Horlings, Hugo M, Huntsman, David G, Huzarski, Tomasz, Jewell, Andrea, Jimenez‐Linan, Mercedes, Jones, Michael E, Kaufmann, Scott H, Kennedy, Catherine J, Khabele, Dineo, Kommoss, Felix KF, Kruitwagen, Roy FPM, Lambrechts, Diether, Le, Nhu D, Lener, Marcin, Lester, Jenny, Leung, Yee, Linder, Anna, Loverix, Liselore, Lubiński, Jan, Madan, Rashna, Maxwell, G Larry, Modugno, Francesmary, Neuhausen, Susan L, Olawaiye, Alexander, Olbrecht, Siel, Orsulic, Sandra, Palacios, José, Pearce, Celeste Leigh, Pike, Malcolm C, Quinn, Carmel M, Mohan, Ganendra Raj, Rodríguez‐Antona, Cristina, Ruebner, Matthias, and Ryan, Andy

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, Orphan Drug, Rare Diseases, Clinical Research, Ovarian Cancer, Cancer, 2.1 Biological and endogenous factors, Female, Humans, Ovarian Neoplasms, Transcription Factors, Carcinoma, RNA, Messenger, Cystadenocarcinoma, Serous, Oncogene Proteins, Cyclin E, CCNE1 amplification, cyclin E1 expression, high-grade serous carcinoma, ovarian cancer, prognosis, AOCS Group, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

BackgroundCyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC.MethodsWithin the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated.ResultsHigh-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss.ConclusionThis study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC.

Published
2023

3. A genetic basis for sex differences in Xp11 translocation renal cell carcinoma

Author

Achom, Mingkee, Sadagopan, Ananthan, Bao, Chunyang, McBride, Fiona, Li, Jiao, Konda, Prathyusha, Tourdot, Richard W., Xu, Qingru, Nakhoul, Maria, Gallant, Daniel S., Ahmed, Usman Ali, O’Toole, Jillian, Freeman, Dory, Lee, Gwo-Shu Mary, Hecht, Jonathan L., Kauffman, Eric C., Einstein, David J., Choueiri, Toni K., Zhang, Cheng-Zhong, and Viswanathan, Srinivas R.

Published
2024
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5. Placenta accreta spectrum care infrastructure: an evidence-based review of needed resources supporting placenta accreta spectrum care

Author

Fitzgerald, Garrett D., Newton, J.M., Atasi, Lamia, Buniak, Christina M., Burgos-Luna, Juan Manuel, Burnett, Brian A., Carver, Alissa R., Cheng, CeCe, Conyers, Steffany, Davitt, Caroline, Deshmukh, Uma, Donovan, Bridget M., Easter, Sara Rae, Einerson, Brett D., Fox, Karin A., Habib, Ashraf S., Harrison, Rachel, Hecht, Jonathan L., Licon, Ernesto, Nino, Julio Mateus, Munoz, Jessian L., Nieto-Calvache, Albaro Jose, Polic, Aleksandra, Ramsey, Patrick S., Salmanian, Bahram, Shamshirsaz, Alireza A., Shamshirsaz, Amir A., Shrivastava, Vineet K., Woolworth, Melissa B., Yurashevich, Mary, Zuckerwise, Lisa, and Shainker, Scott A.

Published
2024
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9. Triaging and Evaluation of Products of Conception in Abortions and Post-Partum Hemorrhage.

Author

Katzman, Philip J. and Hecht, Jonathan L

Subjects
POSTPARTUM hemorrhage, ECTOPIC pregnancy, PLACENTA accreta, CLINICAL medicine, MOLAR pregnancy, ABORTION
Abstract

The proper evaluation of abortion specimens and placentas from stillbirth and post-partum cases is important for adequate clinical care of post-abortion and post-partum patients. The following topics will be reviewed: (1) the importance of evaluation of both fetal and placental tissue in first trimester abortions to confirm an intrauterine pregnancy versus an ectopic pregnancy; (2) the clinical history associated with an abortion specimen or retained products of conception (POC) influences how the pathologist should triage the specimen; (3) the criteria for diagnosis of a molar pregnancy, which is critical for clinicians to know which patients need follow-up; (4) the utility of genetic studies for both diagnosis and appropriate follow-up of the patient; and (5) the pathologic evaluation of specimens from patients with post-partum hemorrhage for placenta accreta spectrum and subinvolution of maternal vessels. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development

Author

Smith, Richard S, Kenny, Connor J, Ganesh, Vijay, Jang, Ahram, Borges-Monroy, Rebeca, Partlow, Jennifer N, Hill, R Sean, Shin, Taehwan, Chen, Allen Y, Doan, Ryan N, Anttonen, Anna-Kaisa, Ignatius, Jaakko, Medne, Livija, Bönnemann, Carsten G, Hecht, Jonathan L, Salonen, Oili, Barkovich, A James, Poduri, Annapurna, Wilke, Martina, de Wit, Marie Claire Y, Mancini, Grazia MS, Sztriha, Laszlo, Im, Kiho, Amrom, Dina, Andermann, Eva, Paetau, Ritva, Lehesjoki, Anna-Elina, Walsh, Christopher A, and Lehtinen, Maria K

Subjects
Biomedical and Clinical Sciences, Neurosciences, Pediatric, Epilepsy, Perinatal Period - Conditions Originating in Perinatal Period, Neurodegenerative, Brain Disorders, Stem Cell Research, Aetiology, Underpinning research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Adolescent, Adult, Animals, Cell Movement, Cells, Cultured, Cerebral Cortex, Child, Child, Preschool, Female, Ferrets, HEK293 Cells, Humans, Infant, Language Development, Male, Megalencephaly, Middle Aged, NAV1.3 Voltage-Gated Sodium Channel, Pedigree, Polymicrogyria, Sodium Channels, Cortical Development, Na(V)1.1, Na(V)1.3, Oromotor, Outer Radial Glia, SCN1A, SCN3A, Speech, Voltage-Gated Sodium Channel, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Channelopathies are disorders caused by abnormal ion channel function in differentiated excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting from pathogenic variants in SCN3A, a gene encoding the voltage-gated sodium channel NaV1.3. Pathogenic NaV1.3 channels showed altered biophysical properties including increased persistent current. Remarkably, affected individuals showed disrupted folding (polymicrogyria) of the perisylvian cortex of the brain but did not typically exhibit epilepsy; they presented with prominent speech and oral motor dysfunction, implicating SCN3A in prenatal development of human cortical language areas. The development of this disorder parallels SCN3A expression, which we observed to be highest early in fetal cortical development in progenitor cells of the outer subventricular zone and cortical plate neurons and decreased postnatally, when SCN1A (NaV1.1) expression increased. Disrupted cerebral cortical folding and neuronal migration were recapitulated in ferrets expressing the mutant channel, underscoring the unexpected role of SCN3A in progenitor cells and migrating neurons.

Published
2018

12. Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification

Author

Qian, Xuyu, primary, Coleman, Kyle, additional, Jiang, Shunzhou, additional, Kriz, Andrea J, additional, Marciano, Jack H, additional, Luo, Chunyu, additional, Cai, Chunhui, additional, Manam, Monica D, additional, Caglayan, Emre, additional, Otani, Aoi, additional, Ghosh, Urmi, additional, Shao, Diane D, additional, Andersen, Rebecca E, additional, Neil, Jennifer E, additional, Johnson, Robert, additional, LeFevre, Alexandra, additional, Hecht, Jonathan L, additional, Miller, Michael B, additional, Sun, Liang, additional, Stringer, Carsen, additional, Li, Mingyao, additional, and Walsh, Christopher A, additional

Published
2024
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16. Special Report of the Society for Maternal-Fetal Medicine Placenta Accreta Spectrum Ultrasound Marker Task Force: Consensus on definition of markers and approach to the ultrasound examination in pregnancies at risk for placenta accreta spectrum

Author

Shainker, Scott A., Coleman, Beverly, Timor-Tritsch, Ilan E., Bhide, Amarnath, Bromley, Bryann, Cahill, Alison G., Gandhi, Manisha, Hecht, Jonathan L., Johnson, Katherine M., Levine, Deborah, Mastrobattista, Joan, Philips, Jennifer, Platt, Lawrence D., Shamshirsaz, Alireza A., Shipp, Thomas D., Silver, Robert M., Simpson, Lynn L., Copel, Joshua A., and Abuhamad, Alfred

Published
2021
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18. Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Author

Aid, Malika, Busman-Sahay, Kathleen, Vidal, Samuel J., Maliga, Zoltan, Bondoc, Stephen, Starke, Carly, Terry, Margaret, Jacobson, Connor A., Wrijil, Linda, Ducat, Sarah, Brook, Olga R., Miller, Andrew D., Porto, Maciel, Pellegrini, Kathryn L., Pino, Maria, Hoang, Timothy N., Chandrashekar, Abishek, Patel, Shivani, Stephenson, Kathryn, Bosinger, Steven E., Andersen, Hanne, Lewis, Mark G., Hecht, Jonathan L., Sorger, Peter K., Martinot, Amanda J., Estes, Jacob D., and Barouch, Dan H.

Published
2020
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24. Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors.

Author

Hathaway, Cassandra A., Townsend, Mary K., Tianyi Wang, Vinci, Christine, Jake-Schoffman, Danielle E., Hecht, Jonathan L., Saeed-Vafa, Daryoush, Moran Segura, Carlos, Nguyen, Jonathan V., Conejo-Garcia, Jose R., Fridley, Brooke L., and Tworoger, Shelley S.

Abstract

Background: Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, and poor outcomes in patients with ovarian cancer. No study has evaluated the impact of smoke exposure across the life-course on B-cell infiltration and Ig abundance in ovarian tumors. Methods: We measured markers of B and plasma cells and Ig isotypes using multiplex immunofluorescence on 395 ovarian cancer tumors in the Nurses' Health Study (NHS)/NHSII. We conducted beta-binomial analyses evaluating odds ratios (OR) and 95% confidence intervals (CI) for positivity of immune markers by cigarette exposure among cases and Cox proportional hazards models to evaluate hazard ratios (HR) and 95% CI for developing tumors with low (+ among ever smokers (OR, 1.54; 95% CI, 1.14-2.07) and ever smokers with no parental smoke exposure (OR, 2.03; 95% CI, 1.18-3.49) versus never smokers. Women with parental cigarette smoke exposure versus not had higher risk of developing ovarian cancer with low IgG+ (HR, 1.51; 95% CI, 1.10-2.09), whereas ever versus never smokers had a lower risk (HR, 0.74; 95% CI, 0.56-0.99). Conclusions: Ever smoking was associated with increased odds of IgA in ovarian tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Supplemental Table 3 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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30. Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys

Author

Martinot, Amanda J., Abbink, Peter, Afacan, Onur, Prohl, Anna K., Bronson, Roderick, Hecht, Jonathan L., Borducchi, Erica N., Larocca, Rafael A., Peterson, Rebecca L., Rinaldi, William, Ferguson, Melissa, Didier, Peter J., Weiss, Deborah, Lewis, Mark G., De La Barrera, Rafael A., Yang, Edward, Warfield, Simon K., and Barouch, Dan H.

Published
2018
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34. S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

Author

Lu, Jie, Esposito, Giuseppe, Scuderi, Caterina, Steardo, Luca, Delli-Bovi, Laurent C, Hecht, Jonathan L, Dickinson, Bryan C, Chang, Christopher J, Mori, Takashi, and Sheen, Volney

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aging, Neurosciences, Neurodegenerative, Acquired Cognitive Impairment, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Down Syndrome, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Alzheimer's Disease, Genetics, Pediatric, Brain Disorders, Dementia, Stem Cell Research - Nonembryonic - Non-Human, Intellectual and Developmental Disabilities (IDD), 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Amyloid beta-Protein Precursor, Animals, Apoptosis, Blotting, Western, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Humans, In Situ Nick-End Labeling, In Vitro Techniques, Membrane Potential, Mitochondrial, Mice, Mice, Transgenic, Nerve Growth Factors, Neurogenesis, Neurons, Oxidative Stress, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Stem Cells, General Science & Technology
Abstract

Down syndrome (DS) is a developmental disorder associated with mental retardation (MR) and early onset Alzheimer's disease (AD). These CNS phenotypes are attributed to ongoing neuronal degeneration due to constitutive overexpression of chromosome 21 (HSA21) genes. We have previously shown that HSA21 associated S100B contributes to oxidative stress and apoptosis in DS human neural progenitors (HNPs). Here we show that DS HNPs isolated from fetal frontal cortex demonstrate not only disturbances in redox states within the mitochondria and increased levels of progenitor cell death but also transition to more gliocentric progenitor phenotypes with a consequent reduction in neuronogenesis. HSA21 associated S100B and amyloid precursor protein (APP) levels are simultaneously increased within DS HNPs, their secretions are synergistically enhanced in a paracrine fashion, and overexpressions of these proteins disrupt mitochondrial membrane potentials and redox states. HNPs show greater susceptibility to these proteins as compared to neurons, leading to cell death. Ongoing inflammation through APP and S100B overexpression further promotes a gliocentric HNPs phenotype. Thus, the loss in neuronal numbers seen in DS is not merely due to increased HNPs cell death and neurodegeneration, but also a fundamental gliocentric shift in the progenitor pool that impairs neuronal production.

Published
2011

40. Supplemental Table 2 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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41. Supplemental Table 4 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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42. Data from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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47. Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC)

Author

Ditzel, Helena M., Strickland, Kyle C., Meserve, Emily E., Stover, Elizabeth, Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Muto, Michael G., Liu, Joyce F., Feltmate, Colleen, Horowitz, Neil, Berkowitz, Ross S., Gupta, Mamta, Hecht, Jonathan L., Lin, Douglas I., Jochumsen, Kirsten M., Welch, William R., Hirsch, Michelle S., Quade, Bradley J., Lee, Kenneth R., Crum, Christopher P., Mutter, George L., Nucci, Marisa R., and Howitt, Brooke E.

Published
2019
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48. Supplemental Figure 1 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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49. Supplemental Table 5 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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50. Supplemental Table 1 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies

Author

Hathaway, Cassandra A., primary, Conejo-Garcia, Jose R., primary, Fridley, Brooke L., primary, Rosner, Bernard, primary, Saeed-Vafa, Daryoush, primary, Moran Segura, Carlos, primary, Nguyen, Jonathan V., primary, Hecht, Jonathan L., primary, Sasamoto, Naoko, primary, Terry, Kathryn L., primary, Tworoger, Shelley S., primary, and Townsend, Mary K., primary

Published
2023
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