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153 results on '"Hecht, Fabio"'

1. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

Author

Asantewaa, Gloria, Tuttle, Emily T., Ward, Nathan P., Kang, Yun Pyo, Kim, Yumi, Kavanagh, Madeline E., Girnius, Nomeda, Chen, Ying, Rodriguez, Katherine, Hecht, Fabio, Zocchi, Marco, Smorodintsev-Schiller, Leonid, Scales, TashJaé Q., Taylor, Kira, Alimohammadi, Fatemeh, Duncan, Renae P., Sechrist, Zachary R., Agostini-Vulaj, Diana, Schafer, Xenia L., Chang, Hayley, Smith, Zachary R., O’Connor, Thomas N., Whelan, Sarah, Selfors, Laura M., Crowdis, Jett, Gray, G. Kenneth, Bronson, Roderick T., Brenner, Dirk, Rufini, Alessandro, Dirksen, Robert T., Hezel, Aram F., Huber, Aaron R., Munger, Joshua, Cravatt, Benjamin F., Vasiliou, Vasilis, Cole, Calvin L., DeNicola, Gina M., and Harris, Isaac S.

Published
2024
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5. Feasibility of a snowball sampling survey to study active surveillance for thyroid microcarcinoma treatment among endocrinologists and surgeons of Brazil

Author

Silva, Isabela Matos da, Nogueira, Taísa Quécia da Silva, Couto, Deborah Nogueira, Lima, Paula Cristina Tanajura Meira, Bonfim, Natália Sampaio Carvalho, Sousa, Izadora Gomes Veiga de, Telles, Ana Clara Tosta, Hecht, Fábio, Alkmim, Nina Ramalho, Penna, Gustavo Cancela e, Ferraz, Carolina, Tomimori, Eduardo, and Ramos, Helton Estrela

Published
2022
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8. Bypassing Cloud Providers' Data Validation to Store Arbitrary Data

Author

Machado, Guilherme Sperb, Hecht, Fabio, Waldburger, Martin, and Stiller, Burkhard

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Cryptography and Security
Abstract

A fundamental Software-as-a-Service (SaaS) characteristic in Cloud Computing is to be application-specific; depending on the application, Cloud Providers (CPs) restrict data formats and attributes allowed into their servers via a data validation process. An ill-defined data validation process may directly impact both security (e.g. application failure, legal issues) and accounting and charging (e.g. trusting metadata in file headers). Therefore, this paper investigates, evaluates (by means of tests), and discusses data validation processes of popular CPs. A proof of concept system was thus built, implementing encoders carefully crafted to circumvent data validation processes, ultimately demonstrating how large amounts of unaccounted, arbitrary data can be stored into CPs., Comment: 8 pages, ISBN 978-1-4673-5229-1

Published
2014

11. Glutathione supports lipid abundancein vivo

Author

Asantewaa, Gloria, primary, Tuttle, Emily T., additional, Ward, Nathan P., additional, Kang, Yun Pyo, additional, Kim, Yumi, additional, Kavanagh, Madeline E., additional, Girnius, Nomeda, additional, Chen, Ying, additional, Duncan, Renae, additional, Rodriguez, Katherine, additional, Hecht, Fabio, additional, Zocchi, Marco, additional, Smorodintsev-Schiller, Leonid, additional, Scales, TashJaé Q., additional, Taylor, Kira, additional, Alimohammadi, Fatemeh, additional, Sechrist, Zachary R, additional, Agostini-Vulaj, Diana, additional, Schafer, Xenia L., additional, Chang, Hayley, additional, Smith, Zachary, additional, O’Connor, Thomas N., additional, Whelan, Sarah, additional, Selfors, Laura M., additional, Crowdis, Jett, additional, Gray, G. Kenneth, additional, Bronson, Roderick T., additional, Brenner, Dirk, additional, Rufini, Alessandro, additional, Dirksen, Robert T., additional, Hezel, Aram F., additional, Huber, Aaron R., additional, Munger, Josh, additional, Cravatt, Benjamin F., additional, Vasiliou, Vasilis, additional, Cole, Calvin L, additional, DeNicola, Gina M., additional, and Harris, Isaac S., additional

Published
2023
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12. COVID-19 and thyroid function: What do we know so far?

Author

Rossetti, Camila Lüdke, primary, Cazarin, Juliana, additional, Hecht, Fabio, additional, Beltrão, Fabyan Esberard de Lima, additional, Ferreira, Andrea Cláudia Freitas, additional, Fortunato, Rodrigo Soares, additional, Ramos, Helton Estrela, additional, and de Carvalho, Denise Pires, additional

Published
2022
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14. Playback Policies for Live and On-Demand P2P Video Streaming

Author

Hecht, Fabio V., Bocek, Thomas, Santos, Flávio Roberto, Stiller, Burkhard, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Bestak, Robert, editor, Kencl, Lukas, editor, Li, Li Erran, editor, Widmer, Joerg, editor, and Yin, Hao, editor

Published
2012
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15. Low muscle mass and high visceral fat mass predict mortality in patients hospitalized with moderate-to-severe COVID-19: a prospective study

Author

Beltrão, Fabyan Esberard de Lima, primary, Beltrão, Daniele Carvalhal de Almeida, additional, Carvalhal, Giulia, additional, Beltrão, Fabyo Napoleão de Lima, additional, de Aquino, Igor Motta, additional, Brito, Thaíse da Silva, additional, Paulino, Barbara Costa, additional, Aires, Elisa, additional, Viegas, Diana, additional, Hecht, Fabio, additional, Halpern, Bruno, additional, Pordeus, Liana Clebia De Morais, additional, Gonçalves, Maria da Conceição Rodrigues, additional, and Ramos, Helton Estrela, additional

Published
2022
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16. Report- and Reciprocity-Based Incentive Mechanisms for Live and On-Demand P2P Video Streaming

Author

Hecht, Fabio Victora, Stiller, Burkhard, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Stiller, Burkhard, editor, and De Turck, Filip, editor

Published
2010
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17. PeerVote: A Decentralized Voting Mechanism for P2P Collaboration Systems

Author

Bocek, Thomas, Peric, Dalibor, Hecht, Fabio, Hausheer, David, Stiller, Burkhard, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Sadre, Ramin, editor, and Pras, Aiko, editor

Published
2009
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18. Enabling Next Generation Peer-to-Peer Services

Author

Hecht, Fabio Victora, Stiller, Burkhard, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Hausheer, David, editor, and Schönwälder, Jürgen, editor

Published
2008
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19. PSH: A Private and Shared History-Based Incentive Mechanism

Author

Bocek, Thomas, Kun, Wang, Hecht, Fabio Victora, Hausheer, David, Stiller, Burkhard, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Hausheer, David, editor, and Schönwälder, Jürgen, editor

Published
2008
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21. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19

Author

de Lima Beltrão, Fabyan Esberard, primary, de Almeida Beltrão, Daniele Carvalhal, additional, Carvalhal, Giulia, additional, de Lima Beltrão, Fabricia Elizabeth, additional, de Souza Braga Filho, Jair, additional, de Brito Oliveira, Jocyel, additional, de Jesus, Joice dos Santos, additional, Machado, Gabriel Jeferson Rodríguez, additional, dos Santos Silva, Hatilla, additional, Teixeira, Helena Mariana Pitangueira, additional, Rodrigues, Juliana Lopes, additional, de Figueiredo, Camila Alexandrina Viana, additional, dos Santos Costa, Ryan, additional, Hecht, Fabio, additional, Bianco, Antonio C, additional, da Conceição Rodrigues Gonçalves, Maria, additional, and Ramos, Helton Estrela, additional

Published
2022
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22. Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients

Author

Beltrão, Fabyan Esberard de Lima, primary, Beltrão, Daniele Carvalhal de Almeida, additional, Carvalhal, Giulia, additional, Beltrão, Fabricia Elizabeth de Lima, additional, Brito, Amanda da Silva, additional, Capistrano, Kamilla Helen Rodrigues da, additional, Bastos, Isis Henriques de Almeida, additional, Hecht, Fabio, additional, Daltro, Carla Hilário da Cunha, additional, Bianco, Antonio Carlos, additional, Gonçalves, Maria da Conceição Rodrigues, additional, and Ramos, Helton Estrela, additional

Published
2021
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23. Congenital hypothyroidism and thyroid cancer

Author

Penna, Gustavo, primary, Rubio, Ileana G S, additional, Brust, Ester Saraiva, additional, Cazarin, Juliana, additional, Hecht, Fabio, additional, Alkmim, Nina Ramalho, additional, Rajão, Kamilla M A Brandão, additional, and Ramos, Helton Estrela, additional

Published
2021
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24. Hypothyroidism induces oxidative stress and DNA damage in breast

Author

Peixoto, Milena Simões, primary, de Vasconcelos e Souza, Andressa, additional, Andrade, Iris Soares, additional, de Carvalho el Giusbi, Carolina, additional, Coelho Faria, Caroline, additional, Hecht, Fabio, additional, Miranda-Alves, Leandro, additional, Ferreira, Andrea Claudia Freitas, additional, Carvalho, Denise Pires, additional, and Fortunato, Rodrigo S, additional

Published
2021
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26. Brief Announcement: The Design and Evaluation of a Distributed Reliable File System

Author

Peric, Dalibor, Bocek, Thomas, Hecht, Fabio, Hausheer, David, Stiller, Burkhard, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Guerraoui, Rachid, editor, and Petit, Franck, editor

Published
2009
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28. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.

Author

Esberard de Lima Beltrão, Fabyan, Carvalhal de Almeida Beltrão, Daniele, Carvalhal, Giulia, de Lima Beltrão, Fabricia Elizabeth, de Souza Braga Filho, Jair, de Brito Oliveira, Jocyel, dos Santos de Jesus, Joice, Rodríguez Machado, Gabriel Jeferson, dos Santos Silva, Hatilla, Pitangueira Teixeira, Helena Mariana, Lopes Rodrigues, Juliana, Viana de Figueiredo, Camila Alexandrina, dos Santos Costa, Ryan, Hecht, Fabio, Bianco, Antonio C., Rodrigues Gonçalves, Maria da Conceição, and Ramos, Helton Estrela

Subjects
GENETIC polymorphisms, THYROID gland function tests, COVID-19 pandemic
Abstract

Context: The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and pulmonary fibrosis. Objective: Our objectives were to evaluate were cumulative mortality during admission according to Thr92Ala-DIO2 polymorphism. Methods: Here we conducted an observational, longitudinal, and prospective cohort study to investigate a possible association between the Thr92Ala- DIO2 polymorphism and intrahospital mortality from COVID-19 in adult patients admitted between June and August 2020. Blood biochemistry, thyroid function tests, length of stay, comorbidities, complications, and severity scores were also studied according to Thr92Ala-DIO2 polymorphism. Results: In total, 220 consecutive patients (median age 62; 48-74 years) were stratified into 3 subgroups: Thr/Thr (n = 79), Thr/Ala (n = 119), and Ala/Ala (n = 23). While the overall mortality was 17.3%, the lethality was lower in Ala/Thr patients (12.6%) than in Thr/Thr patients (21.7%) or Ala/Ala patients (23%). The heterozygous genotype (Thr/Ala) was associated with a 47% reduced risk of intrahospital mortality whereas univariate and multivariate logistic regression adjusted for multiple covariates revealed a reduction that ranged from 51% to 66%. The association of the Thr/Ala genotype with better clinical outcomes was confirmed in a metanalysis of 5 studies, including the present one. Conclusion: Here we provide evidence for a protective role played by Thr92Ala-DIO2 heterozygosity in patients with COVID-19. This protective effect follows an inheritance model known as overdominance, in which the phenotype of the heterozygote lies outside the phenotypical range of both homozygous. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Hypothyroidism induces oxidative stress and DNA damage in breast.

Author

Simões Peixoto, Milena, de Vasconcelos e Souza, Andressa, Soares Andrade, Iris, de Carvalho el Giusbi, Carolina, Coelho Faria, Caroline, Hecht, Fabio, Miranda-Alves, Leandro, Freitas Ferreira, Andrea Claudia, Pires Carvalho, Denise, and Fortunato, Rodrigo S.

Subjects
DNA damage, OXIDATIVE stress, THYROTROPIN, BREAST cancer, LABORATORY rats, HYPOTHYROIDISM, CELL survival
Abstract

Breast cancer and thyroid dysfunctions have been associated for decades. Although many studies suggest a biological correlation, the mechanisms linking these two pathologies have not been elucidated. Reactive oxygen species (ROS) can oxidize lipids, proteins, and DNA molecules and may promote tumor initiation. Hence, we a imed at evaluating the mammary redox balance and genomic instability in a model of experimental hypothyroidism. Female Wistar rats were treated with 0.03% methimazole for 7 or 21 days to evaluate ROS generation, antioxidant enzyme activities, and oxidative stress biomarkers, as well as genomic instability. After 7 days, lower catalase, GPX, and DUOX activities were detected in the breast of hypothyroid group compared to the control while the levels of 4-hydroxynonenal (HNE) were higher. In addition, hypothyroid group showed an increase in γH2Ax/H2Ax ratio. Twenty-one days hypothyroid group had increased catalase and SOD activities, without significant differences between groups in the levels of oxidative stress biomarkers and DNA damage. TSH-treated MCF10A cells showed a higher extracellular, intracellular, and mitochondrial ROS production. Additionally, greater DNA damage was observed in these cells, demonstrated by a higher comet tail DNA percentage and increased 53BP1 foci. Finally, we found that TSH treatment was not able to alter cell viability. The Genome Cancer Atlas (TGCA) data showed that high TSHR expression is associated with more invasive breast cancer types. In conclusion, we demonstrate that oxidative stress and DNA damage in breast a re early events of experimental hypothyroidism. Moreover, high TSH levels induce oxidative stress and genomic instability in mammary cells. [ABSTRACT FROM AUTHOR]

Published
2021
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37. DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress

Author

Fortunato, Rodrigo S., primary, Gomes, Luciana R., additional, Munford, Veridiana, additional, Pessoa, Carolina Fittipaldi, additional, Quinet, Annabel, additional, Hecht, Fabio, additional, Kajitani, Gustavo S., additional, Milito, Cristiane Bedran, additional, Carvalho, Denise P., additional, and Menck, Carlos Frederico Martins, additional

Published
2018
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40. Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus

Author

Gandara, Ana Caroline P., primary, Oliveira, José Henrique M., additional, Nunes, Rodrigo D., additional, Goncalves, Renata L.S., additional, Dias, Felipe A., additional, Hecht, Fabio, additional, Fernandes, Denise C., additional, Genta, Fernando A., additional, Laurindo, Francisco R.M., additional, Oliveira, Marcus F., additional, and Oliveira, Pedro L., additional

Published
2016
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42. Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats

Author

Loureiro, Adriano César Carneiro, primary, Rêgo-Monteiro, Igor Coutinho do, additional, Louzada, Ruy A., additional, Ortenzi, Victor Hugo, additional, Aguiar, Angélica Ponte de, additional, Abreu, Ewerton Sousa de, additional, Cavalcanti-de-Albuquerque, João Paulo Albuquerque, additional, Hecht, Fabio, additional, Oliveira, Ariclécio Cunha de, additional, Ceccatto, Vânia Marilande, additional, Fortunato, Rodrigo S., additional, and Carvalho, Denise P., additional

Published
2016
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44. Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.

Author

Louzada, Ruy Andrade, Corre, Raphael, Ameziane-El-Hassani, Rabii, Hecht, Fabio, Cazarin, Juliana, Buffet, Camille, Carvalho, Denise P., and Dupuy, Corinne

Subjects
CONGENITAL hypothyroidism, APOPTOSIS, OXIDATIVE stress, HEMOPROTEINS, PEROXIDASE, DISEASE risk factors
Abstract

Background: Dual oxidases (DUOX1 and DUOX2) were initially identified as H2O2 sources involved in thyroid hormone synthesis. Congenital hypothyroidism (CH) resulting from inactivating mutations in the DUOX2 gene highlighted that DUOX2 is the major H2O2 provider to thyroperoxidase. The role of DUOX1 in the thyroid remains unknown. A recent study suggests that it could compensate for DUOX2 deficiency in CH. Both DUOX enzymes and their respective maturation factors DUOXA1 and DUOXA2 form a stable complex at the cell surface, which is fundamental for their enzymatic activity. Recently, intra- and intermolecular disulfide bridges were identified that are essential for the structure and the function of the DUOX2–DUOXA2 complex. This study investigated the involvement of cysteine residues conserved in DUOX1 toward the formation of disulfide bridges, which could be important for the function of the DUOX1DUOXA1 complex. Methods: To analyze the role of these cysteine residues in both the targeting and function of dual oxidase, different human DUOX1 mutants were constructed, where the cysteine residues were replaced with glycine. The effect of these mutations on cell surface expression and H2O2-generating activity of the DUOX1–DUOXA1 complex was analyzed. Results: Mutations of two cysteine residues (C118 and C1165), involved in the formation of the intramolecular disulfide bridge between the N-terminal ectodomain and one of the extracellular loops, mildly altered the function and the targeting of DUOX1, while this bridge is crucial for DUOX2 function. Unlike DUOXA2, with respect to DUOX2, the stability of the maturation factor DUOXA1 is not dependent on the oxidative folding of DUOX1. Only mutation of C579 induced a strong alteration of both targeting and function of the oxidase by preventing the covalent interaction between DUOX1 and DUOXA1. Conclusion: An intermolecular disulfide bridge rather than an intramolecular disulfide bridge is important for both the trafficking and H2O2-generating activity of the DUOX1–DUOXA1 complex. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Attacks on internet names

Author

Hecht, Fabio V, Poullie, Patrick, Vancea, Andrei, Stiller, Burkhard, and University of Zurich

Subjects
10009 Department of Informatics, 000 Computer science, knowledge & systems
Published
2012

47. NGN Usage in Future Internet Scenarios

Author

Racz, Peter, Hecht, Fabio, et al, and University of Zurich

Subjects
10009 Department of Informatics, 1705 Computer Networks and Communications, 000 Computer science, knowledge & systems
Published
2010

48. Economic Traffic Management for Overlay Networks

Author

Racz, Peter, Hecht, Fabio V, Hasan, Hasan, Stiller, Burkhard, University of Zurich, Cunningham, P, and Cunningham, M

Subjects
10009 Department of Informatics, 000 Computer science, knowledge & systems
Published
2009

49. An economic traffic management approach to enable the triplewin for users, ISPs, and overlay providers

Author

Hoßfeld, Tobias, Hausheer, David, Hecht, Fabio, Lehrieder, Frank, Oechsner, Simon, Papafili, Ioanna, Racz, Peter, Soursos, Sergios, Staehle, Dirk, Stamoulis, George D, Tran-Gia, Phuoc, Stiller, Burkhard, University of Zurich, Tselentis, Georgios, Domingue, John, Galis, Alex, Gavras, Anastasius, Hausheer, David, Krco, Srdjan, Lotz, Volkmar, Zahariadis, Theodore, and Hoßfeld, Tobias

Subjects
10009 Department of Informatics, 1700 General Computer Science, 000 Computer science, knowledge & systems
Published
2008

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