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This analytical method is a validated measurement procedure for the determination of 9 N-nitrosamines such as N-nitrosodimethylamine [62-75-962-75-9], N-nitrosomethylethylamine [10595-95-610595-95-6], N-nitrosodiethylamine [55-18-555-18-5], N-nitrosodiisopropylamine [601-77-4601-77-4], N-nitrosodi-n-propylamine [621-64-7621-64-7], N-nitrosodi-n-butylamine [924-16-3924-16-3], N-nitrosopiperidine [100-75-4100-75-4], N-nitrosopyrrolidine [930-55-2930-55-2], N-nitrosomorpholine [59-89-259-89-2] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a ThermoSorb-N cartridge using a suitable flow-regulated pump. Afterwards the cartridges are eluted with dichloromethane/methanol (3:1, v:v) and the sample solution is analysed by means of gas chromatography with a thermal energy analyser (TEA) detector. The relative limit of quantification (LOQ) is 0.010 µg/m3 N-nitrosamine per cartridge for an air sample volume of 400 l. The mean recovery for all nine N-nitrosamines was between 96% and 102% and the expanded uncertainty for the analysed N-nitrosamines was between 19% and 27% over the entire measurement range. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction.This method has been tested and recommended for the determination of N-nitrosamines in work areas by the German Social Accident Insurance (DGUV).Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.

This analytical method is a validated measurement procedure for the determination of ethylene oxide [75-21-8] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing air through a tube filled with activated charcoal. The flow is set to 25 ml/min with a recommended air sample volume of 6 l. Sampling is performed over 40 min. The adsorbed ethylene oxide is desorbed using a toluene/carbon disulphide mixture (90+10 v/v) and converted to 2-bromoethanol using hydrobromic acid after the phases have separated and been filtered. The sample is analysed by means of gas chromatography (GC) with a mass selective detector (MSD). The quantitative evaluation is based on a calibration function obtained by means of a multiple-point calibration. The relative limit of quantification (LOQ) is 7 µg/m3 ethylene oxide for an air sample volume of 6 l. The mean recovery was 94% and the expanded uncertainties were between 20 and 21%. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction.This method has been tested and recommended for the determination of ethylene oxide at workplaces by the accident insurance companies.Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.

The analytical method described here permits the determination of platinum in the inhalable particle fraction in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 1 mg/m3 in the inhalable particle fraction.Sampling is performed by drawing a defined volume of air through a quartz fibre filter using a suitable pump and sampling head. The flow rate is set to 10 l/min at a sampling period of 2 h. The platinum particles deposited on the filter are determined by a graphite furnace atomic absorption spectrometer (GF-AAS) after acid digestion using a high-pressure microwave digestion system. Quantitative evaluation is based on an external multiple-point calibration. The limit of quantification is 15 µg/l and 30 µg/m³ for a sampling volume of 1200 l and a sampling period of 2 h. The mean recovery is 95% and the expanded uncertainty for the validation range of 0.1 to 2 mg/m3 is 25–29% for the inhalable particle fraction.

This analytical method is a validated measurement procedure for the determination of 1,3-dioxolane [646-06-0] in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 150 mg/m3. For sampling a defined volume of air is drawn through a sorbent tube (for thermal desorption) filled with Chromosorb 106. The flow rate is set to 5 ml/min and sampling is performed over 2 hours (which corresponds to a sampling volume of 600 ml). The samples to which cyclooctane is added as internal standard are thermally desorbed. The quantitative determination is based on a calibration function, whereby the 1,3-dioxolane concentration of the calibration standard is plotted against the intensities, calculated over the internal cyclooctane standard. The limit of quantification is 12.9 mg/m3 based on an air sample volume of 600 ml. The mean recovery is 97% and the expanded uncertainty for the validation range of 16.3 to 293 mg/m3 is 11.5 to 12.1%.

This analytical method is a validated measurement procedure for the determination of ethylene oxide [75-21-8] in workplace air averaged over the sampling period after personal or stationary sampling. A defined volume of air is drawn through two adsorption tubes packed with Chromosorb 106 and connected in series. For sampling the flow rate of the flow-regulated pump is set to 5 ml/min with an air sample volume of 200 ml (which corresponds to a sampling period of 40 min). For the following analysis the ethylene oxide is thermally desorbed and analysed by means of gas chromatography (GC) with a flame ionisation detector (FID). The quantitative evaluation is based on a calibration function obtained by means of a multiple-point calibration. The relative limit of quantification (LOQ) is 15 µg/m3 ethylene oxide for an air sample volume of 200 ml. The mean recovery was 100% and the expanded uncertainties were between 24 and 27% over the entire measurement range. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction.This method has been tested and recommended for the determination of ethylene oxide at workplaces by the accident insurance companies.Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.

This analytical method is a validated measurement procedure for the determination of o-phenylphenol [90-43-7] in workplace air in a concentration range of one tenth up to twice the currently valid occupational exposure limit value in Germany of 5 mg/m3. For sampling a defined volume of air is drawn through a binder-free quartz fibre filter followed by a silica gel sorbent tube. The flow rate is set to 1 l/min and sampling duration is 2 hours (which correspond to a sampling volume of 120 l). o-Phenylphenol is extracted with 2-propanol and subsequently analysed using liquid chromatography with diode array detection. The quantitative determination is based on a calibration function. The limit of quantification is 0.0183 mg/m3 based on an air sample volume of 120 l. The mean recovery is 94% and the expanded uncertainty for the validation range of 0.5 to 10 mg/m3 is 27 to 30%.

The analytical method described here permits the determination of five linear chain aliphatic dicarboxylic acids with 2 to 6 carbon atoms and terminal carboxy groups occurring as inhalable particles in workplace air. The concentration range covers one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany, which is 1 mg/m3 for oxalic acid and 2 mg/m3 for succinic, glutaric and adipic acid (inhalable fraction). The peak limitation with an excursion factor of 2 can also be checked. At the moment, there is no OELV for malonic acid, so the same concentration range has been considered as for oxalic acid. Sampling is performed using a flow-regulated pump to draw a defined volume of air through a glass fibre filter, which is alkaline-impregnated with sodium carbonate and inserted in a GSP sampling system. The volumetric flow rate is 10 l/min. For sampling, 2 hours or 15 minutes can be used. The collected dicarboxylic acid deposited on the filter is extracted by means of an aqueous sodium carbonate/sodium hydroxide solution and analysed by means of ion chromatography using a conductivity detector. Quantitative determination is based on multiple-point calibrations with external standards. For an air sample volume of 1200 litres, the relative limit of quantification (LOQ) is in the range from 0.0002 mg/m3 for oxalic acid and 0.0009 mg/m3 for succinic acid. With LOQs less than 0.0076 mg/m3, the measurement of the short-term exposure limit (STEL) is also enabled with an air sample volume of 150 litres. The recoveries of the five dicarboxylic acids range from 96% to 110% and the expanded uncertainty is less than 29%.

The analytical method described here permits the determination of platinum in the inhalable particle fraction in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 1 mg/m3 in the inhalable particle fraction.Sampling is performed by drawing a defined volume of air through a quartz fibre filter using a suitable pump and sampling head. The flow rate is set to 10 l/min at a sampling period of 2 h. The platinum particles deposited on the filter are determined by a graphite furnace atomic absorption spectrometer (GF-AAS) after acid digestion using a high-pressure microwave digestion system. Quantitative evaluation is based on an external multiple-point calibration. The limit of quantification is 15 µg/l and 30 µg/m3 for a sampling volume of 1200 l and a sampling period of 2 h. The mean recovery is 95% and the expanded uncertainty for the validation range of 0.1 to 2 mg/m3 is 25–29% for the inhalable particle fraction.

This analytical method is a validated measurement procedure for the determination of diphenylether [101-84-8] in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 7.1 mg/m3. For sampling a defined volume of air is drawn through a binder-free quartz fiber filter followed by a silica gel sorbent tube. The flow rate is set to 0.5 l/min and sampling duration is 2 hours (which correspond to a sampling volume of 60 l). Diphenylether is extracted with 2-propanol and subsequently analysed using liquid chromatography with diode array detection. The quantitative determination is based on a calibration function. The limit of quantification is 0.008 mg/m3 based on an air sample volume of 60 l. The mean recovery is 95.3% and the expanded uncertainty for the validation range of 0.71 to 14.2 mg/m3 is 24 to 25%.

This analytical method is a validated measurement procedure for the determination of o-phenylphenol [90-43-7] in workplace air in a concentration range of one tenth up to twice the currently valid occupational exposure limit in Germany of 5 mg/m3. For sampling a defined volume of air is drawn through a binder-free quartz fibre filter followed by a silica gel sorbent tube. The flow rate is set to 1 l/min and sampling duration is 2 hours (which correspond to a sampling volume of 120 l). o-Phenylphenol is extracted with 2-propanol and subsequently analysed using liquid chromatography with diode array detection. The quantitative determination is based on a calibration function. The limit of quantification is 0.0183 mg/m3 based on an air sample volume of 120 l. The mean recovery is 94% and the expanded uncertainty for the validation range of 0.5 to 10 mg/m3 is 27 to 30%.