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2. Case Series of Laboratory-Associated Zika Virus Disease, United States, 2016-2019

Author

Hills, Susan L., Morrison, Andrea, Stuck, Shawna, Sandhu, Kayleigh, Mason, Krystal L., Stanek, Danielle, Gabel, Julie, Osborne, Matthew A., Schroeder, Betsy A., Rico, Edhelene, Drenzek, Cherie L., Gallagher, Glen R., Fiddner, Jennifer, Heberlein-Larson, Lea A., Brown, Catherine M., and Fischer, Marc

Subjects
Occupational diseases -- Case studies -- Risk factors, Work-related injuries -- Case studies -- Risk factors, Laboratory technicians -- Case studies -- Health aspects, Health
Abstract

Zika virus is a flavivirus that was first isolated in 1947 from a rhesus macaque in the Zika Forest in Uganda. Zika virus is primarily transmitted to humans by infected [...]

Published
2021
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5. First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities — May 2014

Author

Bialek, Stephanie R., Allen, Donna, Alvarado-Ramy, Francisco, Arthur, Ray, Balajee, Arunmozhi, Bell, David, Best, Susan, Blackmore, Carina, Breakwell, Lucy, Cannons, Andrew, Brown, Clive, Cetron, Martin, Chea, Nora, Chommanard, Christina, Cohen, Nicole, Conover, Craig, Crespo, Antonio, Creviston, Jeanean, Curns, Aaron T., Dahl, Rebecca, Dearth, Stephanie, Alfred, DeMaria, Echols, Fred, Erdman, Dean D., Feikin, Daniel, Frias, Mabel, Gerber, Susan I., Gulati, Reena, Hale, Christa, Haynes, Lia M., Heberlein-Larson, Lea, Holton, Kelly, Ijaz, Kashef, Kapoor, Minal, Kohl, Katrin, Kuhar, David T., Kumar, Alan M., Kundich, Marianne, Lippold, Susan, Liu, Lixia, Lovchik, Judith C., Madoff, Larry, Martell, Sandra, Matthews, Sarah, Moore, Jessica, Murray, Linda R., Onofrey, Shauna, Pallansch, Mark A., Pesik, Nicki, Pham, Huong, Pillai, Satish, Pontones, Pam, Poser, Sarah, Pringle, Kimberly, Pritchard, Scott, Rasmussen, Sonja, Richards, Shawn, Sandoval, Michelle, Schneider, Eileen, Schuchat, Anne, Sheedy, Kristine, Sherin, Kevin, Swerdlow, David L., Tappero, Jordan W., Vernon, Michael O., Watkins, Sharon, and Watson, John

Published
2014

6. Prolonged Detection of Zika Virus RNA in Pregnant Women

Author

Meaney-Delman, Dana, Oduyebo, Titilope, Polen, Kara N.D., White, Jennifer L., Bingham, Andrea M., Slavinski, Sally A., Heberlein-Larson, Lea, St. George, Kirsten, Rakeman, Jennifer L., Hills, Susan, Olson, Christine K., Adamski, Alys, Culver Barlow, Lauren, Lee, Ellen H., Likos, Anna M., Muñoz, Jorge L., Petersen, Emily E., Dufort, Elizabeth M., Dean, Amy B., Cortese, Margaret M., Santiago, Gilberto A., Bhatnagar, Julu, Powers, Ann M., Zaki, Sherif, Petersen, Lyle R., Jamieson, Denise J., and Honein, Margaret A.

Published
2016
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7. Routine screening of pregnant women for Zika virus in the setting of local transmission—Miami−Dade County, Florida, 2016–2017

Author

Logue, Teresa, primary, Muse, Nicole, additional, Mejia-Echeverry, Álvaro, additional, Zhang, Guoyan, additional, Etienne, Marie, additional, Rojas, Mercedes, additional, Timoszyk, Elizabeth, additional, Fernandez, Danielle, additional, Calle, Stephanie, additional, Goldberg, Cynthia, additional, Arshad, Amena, additional, Rico, Edhelene, additional, Noya-Chaveco, Pedro, additional, Jean, Reynald, additional, Rivera, Lillian, additional, Mendoza, Rafael, additional, White, Stephen, additional, Gillis, Leah D., additional, Heberlein-Larson, Lea, additional, Villalta, Yesenia, additional, and Blackmore, Carina, additional

Published
2019
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8. Journal of Virology

Author

Tan, Yi, Lam, Tommy Tsan-Yuk, Heberlein-Larson, Lea A., Smole, Sandra C., Auguste, Albert J., Hennigan, Scott, Halpin, Rebecca A., Fedorova, Nadia, Puri, Vinita, Stockwell, Timothy B., Shilts, Meghan H., Andreadis, Theodore G., Armstrong, Philip M., Tesh, Robert B., Weaver, Scott C., Unnasch, Thomas R., Ciota, Alexander T., Kramer, Laura D., Das, Suman R., and Entomology

Subjects
Virology, 07 Agricultural And Veterinary Sciences, 11 Medical And Health Sciences, 06 Biological Sciences
Abstract

Eastern equine encephalitis virus (EEEV) has a high case-fatality rate in horses and humans, and Florida has been hypothesized to be the source of EEEV epidemics for the northeastern United States. To test this hypothesis, we sequenced complete genomes of 433 EEEV strains collected within the United States from 1934 to 2014. Phylogenetic analysis suggested EEEV evolves relatively slowly and that transmission is enzootic in Florida, characterized by higher genetic diversity and long-term local persistence. In contrast, EEEV strains in New York and Massachusetts were characterized by lower genetic diversity, multiple introductions, and shorter local persistence. Our phylogeographic analysis supported a source-sink model in which Florida is the major source of EEEV compared to the other localities sampled. In sum, this study revealed the complex epidemiological dynamics of EEEV in different geographic regions in the United States and provided general insights into the evolution and transmission of other avian mosquito-borne viruses in this region. Published version

Published
2018

9. Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic

Author

Grubaugh, Nathan D., primary, Saraf, Sharada, additional, Gangavarapu, Karthik, additional, Watts, Alexander, additional, Tan, Amanda L., additional, Oidtman, Rachel J., additional, Ladner, Jason T., additional, Oliveira, Glenn, additional, Matteson, Nathaniel L., additional, Kraemer, Moritz U.G., additional, Vogels, Chantal B.F., additional, Hentoff, Aaron, additional, Bhatia, Deepit, additional, Stanek, Danielle, additional, Scott, Blake, additional, Landis, Vanessa, additional, Stryker, Ian, additional, Cone, Marshall R., additional, Kopp, Edgar W., additional, Cannons, Andrew C., additional, Heberlein-Larson, Lea, additional, White, Stephen, additional, Gillis, Leah D., additional, Ricciardi, Michael J., additional, Kwal, Jaclyn, additional, Lichtenberger, Paola K., additional, Magnani, Diogo M., additional, Watkins, David I., additional, Palacios, Gustavo, additional, Hamer, Davidson H., additional, Gardner, Lauren M., additional, Perkins, T. Alex, additional, Baele, Guy, additional, Khan, Kamran, additional, Morrison, Andrea, additional, Isern, Sharon, additional, Michael, Scott F., additional, and Andersen, Kristian G., additional

Published
2019
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11. Viruses Associated With Acute Respiratory Infections and Influenza-like Illness Among Outpatients From the Influenza Incidence Surveillance Project, 2010–2011

Author

Fowlkes, Ashley, Giorgi, Andrea, Erdman, Dean, Temte, Jon, Goodin, Kate, Di Lonardo, Steve, Sun, Yumei, Martin, Karen, Feist, Michelle, Linz, Rachel, Boulton, Rachelle, Bancroft, Elizabeth, McHugh, Lisa, Lojo, Jose, Filbert, Kimberly, Finelli, Lyn, Lemmings, Jennifer, Whitaker, Brett, Lang, Brian, Lynfield, Ruth, Carroll, Larry, Boxrud, Dave, Stark, Lillian, Heberlein-Larson, Lea, Mock, Valerie, Desjardin, Lucy, Trythall, Mike, Fu, Jie, Atkinson, Annette, Gren, Lisa, Reisdorf, Erik, Grenz, LaDonna, Biggs, Christianne, Sturgeon, Joan, Rivas, Hector, Wolf, Bruce, Lute, James, Kurkjian, Katie, and Toney, Denise

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Orthomyxoviridae, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Influenza, Human, Outpatients, Epidemiology, medicine, Humans, Immunology and Allergy, Cumulative incidence, 030212 general & internal medicine, Child, Intensive care medicine, Respiratory Tract Infections, Aged, 0303 health sciences, Influenza-like illness, biology, Respiratory tract infections, Reverse Transcriptase Polymerase Chain Reaction, 030306 microbiology, business.industry, Incidence, Incidence (epidemiology), Infant, virus diseases, Respiratory infection, Middle Aged, biology.organism_classification, United States, respiratory tract diseases, 3. Good health, Infectious Diseases, Child, Preschool, Population Surveillance, Respiratory virus, Female, business
Abstract

Background The Influenza Incidence Surveillance Project (IISP) monitored outpatient acute respiratory infection (ARI; defined as the presence of ≥ 2 respiratory symptoms not meeting ILI criteria) and influenza-like illness (ILI) to determine the incidence and contribution of associated viral etiologies. Methods From August 2010 through July 2011, 57 outpatient healthcare providers in 12 US sites reported weekly the number of visits for ILI and ARI and collected respiratory specimens on a subset for viral testing. The incidence was estimated using the number of patients in the practice as the denominator, and the virus-specific incidence of clinic visits was extrapolated from the proportion of patients testing positive. Results The age-adjusted cumulative incidence of outpatient visits for ARI and ILI combined was 95/1000 persons, with a viral etiology identified in 58% of specimens. Most frequently detected were rhinoviruses/enteroviruses (RV/EV) (21%) and influenza viruses (21%); the resulting extrapolated incidence of outpatient visits was 20 and 19/1000 persons respectively. The incidence of influenza virus-associated clinic visits was highest among patients aged 2-17 years, whereas other viruses had varied patterns among age groups. Conclusions The IISP provides a unique opportunity to estimate the outpatient respiratory illness burden by etiology. Influenza virus infection and RV/EV infection(s) represent a substantial burden of respiratory disease in the US outpatient setting, particularly among children.

Published
2013
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12. Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic

Author

Tan, Yi, primary, Pickett, Brett E., additional, Shrivastava, Susmita, additional, Gresh, Lionel, additional, Balmaseda, Angel, additional, Amedeo, Paolo, additional, Hu, Lihui, additional, Puri, Vinita, additional, Fedorova, Nadia B., additional, Halpin, Rebecca A., additional, LaPointe, Matthew P., additional, Cone, Marshall R., additional, Heberlein-Larson, Lea, additional, Kramer, Laura D., additional, Ciota, Alexander T., additional, Gordon, Aubree, additional, Shabman, Reed S., additional, Das, Suman R., additional, and Harris, Eva, additional

Published
2018
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13. Characterization of the Genome Sequences of Enterovirus C109 from Two Respiratory Disease Cases in Florida, 2016

Author

Ng, Terry Fei Fan, primary, Yglesias, Joseph A., additional, Stevenson-Yuen, Tiffany A., additional, Wolfe, Caitlin M., additional, Cone, Marshall R., additional, Heberlein-Larson, Lea A., additional, Maher, Kaija, additional, Rogers, Shannon, additional, Chern, Shur-Wern Wang, additional, Montmayeur, Anna, additional, Castro, Christina, additional, and Nix, W. Allan, additional

Published
2018
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14. Large-Scale Complete-Genome Sequencing and Phylodynamic Analysis of Eastern Equine Encephalitis Virus Reveals Source-Sink Transmission Dynamics in the United States

Author

Tan, Yi, primary, Lam, Tommy Tsan-Yuk, additional, Heberlein-Larson, Lea A., additional, Smole, Sandra C., additional, Auguste, Albert J., additional, Hennigan, Scott, additional, Halpin, Rebecca A., additional, Fedorova, Nadia, additional, Puri, Vinita, additional, Stockwell, Timothy B., additional, Shilts, Meghan H., additional, Andreadis, Theodore, additional, Armstrong, Philip M., additional, Tesh, Robert B., additional, Weaver, Scott C., additional, Unnasch, Thomas R., additional, Ciota, Alexander T., additional, Kramer, Laura D., additional, and Das, Suman R., additional

Published
2018
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15. Partnerships Involved in Public Health Testing for Zika Virus in Florida, 2016

Author

Ned-Sykes, Renee M., Pentella, Michael A., Salerno, Reynolds M., St. George, Kirsten, Heberlein-Larson, Lea, Gillis, Leah D., Morrison, Andrea, Scott, Blake, Cook, Mary, Cannons, Andrew, Quaye, Elesi, White, Stephen, Cone, Marshall, Mock, Valerie, Schiffer, Jarad, Lonsway, David, Petway, Marla, Otis, Aaron, Stanek, Danielle, Hamilton, Janet, and Crowe, Susanne

Abstract

The emergence of Zika virus in the Americas in 2015 and its association with birth defects and other adverse health outcomes triggered an unprecedented public health response and a demand for testing. In 2016, when Florida exceeded state public health laboratory capacity for diagnostic testing, the state formed partnerships with federal and commercial laboratories. Eighty-two percent of the testing (n = 33 802 of 41 008 specimens) by the laboratory partners, including Florida’s Bureau of Public Health Laboratories (BPHL; n = 13 074), a commercial laboratory (n = 19 214), and the Centers for Disease Control and Prevention (CDC; n = 1514), occurred from July through November 2016, encompassing the peak period of local transmission. These partnerships allowed BPHL to maintain acceptable test turnaround times of 1 to 4 days for nucleic acid testing and 3 to 7 days for serologic testing. Lessons learned from this response to inform future outbreaks included the need for early planning to establish outside partnerships, adding specimen triage strategies to surge plans, and integrating state and CDC information systems.

Published
2019
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16. First Complete Genome Sequences of Two Keystone Viruses from Florida

Author

Stockwell, Timothy B., primary, Heberlein-Larson, Lea A., additional, Tan, Yi, additional, Halpin, Rebecca A., additional, Fedorova, Nadia, additional, Katzel, Daniel A., additional, Smole, Sandra, additional, Unnasch, Thomas R., additional, Kramer, Laura D., additional, and Das, Suman R., additional

Published
2015
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17. Routine screening of pregnant women for Zika virus in the setting of local transmission-Miami-Dade County, Florida, 2016-2017.

Author

Logue, Teresa, Muse, Nicole, Mejia-Echeverry, Álvaro, Zhang, Guoyan, Etienne, Marie, Rojas, Mercedes, Timoszyk, Elizabeth, Fernandez, Danielle, Calle, Stephanie, Goldberg, Cynthia, Arshad, Amena, Rico, Edhelene, Noya-Chaveco, Pedro, Jean, Reynald, Rivera, Lillian, Mendoza, Rafael, White, Stephen, Gillis, Leah D., Heberlein-Larson, Lea, and Villalta, Yesenia

Subjects
ZIKA virus, PREGNANT women, ZIKA virus infections, MEDICAL personnel
Published
2019
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18. Epidemiologic Comparison of Laboratory-Confirmed Influenza Virus B Yamagata and Victoria Lineage Infections During the 2014–2015 Influenza Season

Author

Fowlkes, Ashley, primary, Steffens, Andrea, additional, Temte, Jonathan, additional, Reisdorf, Erik, additional, Rubino, Heather, additional, Martin, Karen, additional, Boxrud, David, additional, Wotton, Jason, additional, Brannan, Lesley, additional, Ledbetter, Johnathan, additional, Selzer, Christine, additional, Green, Nicole, additional, Diaz-Decaro, John, additional, Lonardo, Steve Di, additional, Fu, Jie, additional, Lindstrom, Stephen, additional, and Heberlein-Larson, Lea, additional

Published
2015
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19. First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities—May 2014

Author

Bialek, Stephanie R., primary, Allen, Donna, additional, Alvarado-Ramy, Francisco, additional, Arthur, Ray, additional, Balajee, Arunmozhi, additional, Bell, David, additional, Best, Susan, additional, Blackmore, Carina, additional, Breakwell, Lucy, additional, Cannons, Andrew, additional, Brown, Clive, additional, Cetron, Martin, additional, Chea, Nora, additional, Chommanard, Christina, additional, Cohen, Nicole, additional, Conover, Craig, additional, Crespo, Antonio, additional, Creviston, Jeanean, additional, Curns, Aaron T., additional, Dahl, Rebecca, additional, Dearth, Stephanie, additional, DeMaria, Alfred, additional, Echols, Fred, additional, Erdman, Dean D., additional, Feikin, Daniel, additional, Frias, Mabel, additional, Gerber, Susan I., additional, Gulati, Reena, additional, Hale, Christa, additional, Haynes, Lia M., additional, Heberlein-Larson, Lea, additional, Holton, Kelly, additional, Ijaz, Kashef, additional, Kapoor, Minal, additional, Kohl, Katrin, additional, Kuhar, David T., additional, Kumar, Alan M., additional, Kundich, Marianne, additional, Lippold, Susan, additional, Liu, Lixia, additional, Lovchik, Judith C., additional, Madoff, Larry, additional, Martell, Sandra, additional, Matthews, Sarah, additional, Moore, Jessica, additional, Murray, Linda R., additional, Onofrey, Shauna, additional, Pallansch, Mark A., additional, Pesik, Nicki, additional, Pham, Huong, additional, Pillai, Satish, additional, Pontones, Pam, additional, Pringle, Kimberly, additional, Pritchard, Scott, additional, Rasmussen, Sonja, additional, Richards, Shawn, additional, Sandoval, Michelle, additional, Schneider, Eileen, additional, Schuchat, Anne, additional, Sheedy, Kristine, additional, Sherin, Kevin, additional, Swerdlow, David L., additional, Tappero, Jordan W., additional, Vernon, Michael O., additional, Watkins, Sharon, additional, and Watson, John, additional

Published
2014
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23. Bacillus anthracisVirulent Plasmid pX02 Genes Found in Large Plasmids of Two Other BacillusSpecies

Author

Luna, Vicki A., King, Debra S., Peak, K. Kealy, Reeves, Frank, Heberlein-Larson, Lea, Veguilla, William, Heller, L., Duncan, Kathleen E., Cannons, Andrew C., Amuso, Philip, and Cattani, Jacqueline

Abstract

ABSTRACTIn order to cause the disease anthrax, Bacillus anthracisrequires two plasmids, pX01 and pX02, which carry toxin and capsule genes, respectively, that are used as genetic targets in the laboratory detection of the bacterium. Clinical, forensic, and environmental samples that test positive by PCR protocols established by the Centers for Disease Control and Prevention for B. anthracisare considered to be potentially B. anthracisuntil confirmed by culture and a secondary battery of tests. We report the presence of 10 genes (acpA, capA, capB, capC, capR, capD, IS1627, ORF 48, ORF 61, and repA) and the sequence for the capsule promoter normally found on pX02 in Bacillus circulansand a Bacillusspecies closely related to Bacillus luciferensis. Tests revealed these sequences to be present on a large plasmid in each isolate. The 11 sequences consistently matched to B. anthracisplasmid pX02, GenBank accession numbers AF188935.1, AE011191.1, and AE017335.3. The percent nucleotide identities for capDand the capsule promoter were 99.9% and 99.7%, respectively, and for the remaining nine genes, the nucleotide identity was 100% for both isolates. The presence of these genes, which are usually associated with the pX02 plasmid, in two soil Bacillusspecies unrelated to B. anthracisalerts us to the necessity of identifying additional sequences that will signal the presence of B. anthracisin clinical, forensic, and environmental samples.

Published
2006
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24. Large-Scale Complete-Genome Sequencing and Phylodynamic Analysis of Eastern Equine Encephalitis Virus Reveals Source-Sink Transmission Dynamics in the United States.

Author

Yi Tan, Tommy Tsan-Yuk Lam, Heberlein-Larson, Lea A., Smole, Sandra C., Auguste, Albert J., Hennigan, Scott, Halpin, Rebecca A., Fedorova, Nadia, Puri, Vinita, Stockwell, Timothy B., Shilts, Meghan H., Andreadis, Theodore, Armstrong, Philip M., Tesh, Robert B., Weaver, Scott C., Unnasch, Thomas R., Ciota, Alexander T., Kramer, Laura D., and Das, Suman R.

Subjects
*VIRAL genomes, *SOURCE-sink dynamics, *VIRAL genetics, *PUBLIC health, *EASTERN equine encephalomyelitis virus
Abstract

Eastern equine encephalitis virus (EEEV) has a high case-fatality rate in horses and humans, and Florida has been hypothesized to be the source of EEEV epidemics for the northeastern United States. To test this hypothesis, we sequenced complete genomes of 433 EEEV strains collected within the United States from 1934 to 2014. Phylogenetic analysis suggested EEEV evolves relatively slowly and that transmission is enzootic in Florida, characterized by higher genetic diversity and long-term local persistence. In contrast, EEEV strains in New York and Massachusetts were characterized by lower genetic diversity, multiple introductions, and shorter local persistence. Our phylogeographic analysis supported a source-sink model in which Florida is the major source of EEEV compared to the other localities sampled. In sum, this study revealed the complex epidemiological dynamics of EEEV in different geographic regions in the United States and provided general insights into the evolution and transmission of other avian mosquito-borne viruses in this region. IMPORTANCE Eastern equine encephalitis virus (EEEV) infections are severe in horses and humans on the east coast of the United States with a >90% mortality rate in horses, an ~33% mortality rate in humans, and significant brain damage in most human survivors. However, little is known about the evolutionary characteristics of EEEV due to the lack of genome sequences. By generating large collection of publicly available complete genome sequences, this study comprehensively determined the evolution of the virus, described the epidemiological dynamics of EEEV in different states in the United States, and identified Florida as one of the major sources. These results may have important implications for the control and prevention of other mosquito-borne viruses in the Americas. [ABSTRACT FROM AUTHOR]

Published
2018
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25. Pneumonia Associated with an Influenza A H3 Outbreak at a Skilled Nursing Facility--Florida, 2014.

Author

Jordan JG, Pritchard S, Nicholson G, Winston T, Gumke M, Rubino H, Watkins S, Heberlein-Larson LA, and Likos A

Subjects
Adult, Aged, Aged, 80 and over, Female, Florida epidemiology, Humans, Male, Middle Aged, Disease Outbreaks, Influenza A Virus, H3N2 Subtype isolation & purification, Influenza, Human epidemiology, Pneumonia, Viral epidemiology, Skilled Nursing Facilities
Abstract

In December 2014, the Florida Department of Health, Bureau of Epidemiology, was notified that 18 of 95 (19%) residents at a skilled nursing facility had radiographic evidence of pneumonia and were being treated with antibiotics. Two residents were hospitalized, one of whom died. A second resident died at the facility. The Florida Department of Health conducted an outbreak investigation to ascertain all cases through active case finding, identify the etiology, provide infection control guidance, and recommend treatment or prophylaxis, if indicated.

Published
2015
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