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8. Cover

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

9. Being Dominican

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

13. Dominicans in the World

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

19. Introduction: Dominicans on Mission

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

21. Index

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

22. List of Contributors

Author

Margaret M. McGuinness, Jeffrey M. Burns, Arlene Bachanov, Elizabeth Michael Boyle, James T. Carroll, and Heath Carter

Published
2020

25. Index

Author

Heath Carpenter

Published
2019

33. Contents

Author

Heath Carpenter

Published
2019

34. Notes

Author

Heath Carpenter

Published
2019

41. Diagnosing variant Creutzfeldt-Jakob disease: a retrospective analysis of the first 150 cases in the UK.

Author

Heath CA, Cooper SA, Murray K, Lowman A, Henry C, Macleod MA, Stewart G, Zeidler M, McKenzie JM, Knight RS, Will RG, Heath, C A, Cooper, S A, Murray, K, Lowman, A, Henry, C, MacLeod, M A, Stewart, G, Zeidler, M, and McKenzie, J M

Abstract

Introduction: Establishing an early clinical diagnosis in variant Creutzfeldt-Jakob disease (vCJD) can be difficult, resulting in extended periods of uncertainty for many families and sometimes a view that patients have been subjected to unnecessary investigations. This issue is accentuated by the progressive nature of vCJD and by the difficulty in achieving a confident clinical diagnosis before an advanced stage of illness. Although diagnostic delay may be a result of the non-specific early clinical features, a systematic analysis of the process of diagnosis was undertaken, with the aim of trying to achieve earlier diagnosis of vCJD.Methods: Retrospective case file analysis was undertaken of the first 150 definite and clinically probable cases of vCJD identified by the UK surveillance system.Results: There is a significant interval between illness onset and presentation to a primary care physician, which is influenced by the nature of the initial clinical features. Neurological review is invariably sought following the development of clinical signs and a diagnosis is then established relatively quickly. Despite the progressive clinical course, a confident clinical diagnosis is not usually achieved until a relatively advanced stage of illness (mean time to diagnosis 10.5 months) with a more rapid clinical progression accounting for those cases diagnosed earlier after symptom onset.Conclusions: Early clinical diagnosis in vCJD is not possible in the great majority of cases because of non-specific initial symptoms. Once neurological signs develop, a diagnosis is usually made promptly but this is often at a relatively advanced stage of illness. The inherent delays in the diagnosis of vCJD have implications for those involved in both public health and therapeutics. [ABSTRACT FROM AUTHOR]

Published
2011
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42. Cover

Author

Heath Cabot

Published
2014

45. Preface

Author

Heath Cabot

Published
2014

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