161,643 results on '"Heath, A"'
Search Results
2. Effect modification and non-collapsibility leads to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making
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Phillippo, David M., Remiro-Azócar, Antonio, Heath, Anna, Baio, Gianluca, Dias, Sofia, Ades, A. E., and Welton, Nicky J.
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Statistics - Methodology - Abstract
Effect modification occurs when a covariate alters the relative effectiveness of treatment compared to control. It is widely understood that, when effect modification is present, treatment recommendations may vary by population and by subgroups within the population. Population-adjustment methods are increasingly used to adjust for differences in effect modifiers between study populations and to produce population-adjusted estimates in a relevant target population for decision-making. It is also widely understood that marginal and conditional estimands for non-collapsible effect measures, such as odds ratios or hazard ratios, do not in general coincide even without effect modification. However, the consequences of both non-collapsibility and effect modification together are little-discussed in the literature. In this paper, we set out the definitions of conditional and marginal estimands, illustrate their properties when effect modification is present, and discuss the implications for decision-making. In particular, we show that effect modification can result in conflicting treatment rankings between conditional and marginal estimates. This is because conditional and marginal estimands correspond to different decision questions that are no longer aligned when effect modification is present. For time-to-event outcomes, the presence of covariates implies that marginal hazard ratios are time-varying, and effect modification can cause marginal hazard curves to cross. We conclude with practical recommendations for decision-making in the presence of effect modification, based on pragmatic comparisons of both conditional and marginal estimates in the decision target population. Currently, multilevel network meta-regression is the only population-adjustment method capable of producing both conditional and marginal estimates, in any decision target population., Comment: 30 pages, 8 figures
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- 2024
3. Effect of Ti-doping on the dimer transition in Lithium Ruthenate
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Jain, Sheetal, Zhou, Zhengbang, Horsley, Ezekiel, Heath, Christopher J. S., Shakouri, Mohsen, Xiao, Qunfeng, Chen, Ning, Chen, Weifeng, King, Graham, and Kim, Young-June
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Condensed Matter - Materials Science - Abstract
We carried out a comprehensive crystal structure characterization of Ti-doped lithium ruthenate (Li$_2$Ti$_x$Ru$_{1-x}$O$_3$), to investigate the effect of Ti-doping on the structural phase transition. Experimental tools sensitive to the average structure (X-ray diffraction), as well as those sensitive to local structure (Extended X-ray Absorption Fine Structure, EXAFS; pair distribution function, PDF) are used. We observed non-monotonic dependence of the structural transition temperature on the Ti-doping level. At low doping, the transition temperature slightly increases with doping, while at high doping, the temperature decreases significantly with doping. We note two important observations from our studies. First, Ti K-edge EXAFS data shows persistent Ti-Ru dimerization even with substantial Ti doping. Second, we were able to use the PDF data to estimate the dimer correlation length above the transition temperature, which would correspond to the size of the proposed local `dimer clusters' formed by Ru-Ru and Ti-Ru neighbours. The dimer correlation length is found to be around 10~\AA, which remains robust regardless of doping. Our study therefore suggests that Ti$^{4+}$ with its $d^0$ electronic configuration is a special type of dopant when replacing Ru., Comment: 12 pages, 11 figures
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- 2024
4. On the proper rainbow saturation numbers of cliques, paths, and odd cycles
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Baker, Dustin, Gomez-Leos, Enrique, Halfpap, Anastasia, Heath, Emily, Martin, Ryan R., Miller, Joe, Parker, Alex, Pungello, Hope, Schwieder, Coy, and Veldt, Nick
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Mathematics - Combinatorics - Abstract
Given a graph $H$, we say a graph $G$ is properly rainbow $H$-saturated if there is a proper edge-coloring of $G$ which contains no rainbow copy of $H$, but adding any edge to $G$ makes such an edge-coloring impossible. The proper rainbow saturation number, denoted $\text{sat}^*(n,H)$, is the minimum number of edges in an $n$-vertex rainbow $H$-saturated graph. We determine the proper rainbow saturation number for paths up to an additive constant and asymptotically determine $\text{sat}^*(n,K_4)$. In addition, we bound $\text{sat}^*(n,H)$ when $H$ is a larger clique, tree of diameter at least 4, or odd cycle.
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- 2024
5. The structure of Hurwitz numbers with fixed ramification profile and varying genus
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Do, Norman, He, Jian, and Robertson, Heath
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Mathematics - Combinatorics ,Mathematics - Algebraic Geometry ,05A15, 05E14, 14H30, 14N10 - Abstract
In 1891, Hurwitz introduced the enumeration of genus $g$, degree $d$, branched covers of the Riemann sphere with simple ramification over prescribed points and no branching elsewhere. He showed that for fixed degree $d$, the enumeration possesses a remarkable structure. More precisely, it can be expressed as a linear combination of exponentials $m^{2g-2+2d}$, where $m$ ranges over the integers from $1$ to $\binom{d}{2}$. In this paper, we generalise this structural result to Hurwitz numbers that enumerate branched covers which also have a prescribed ramification profile over one point. Our proof fundamentally uses the infinite wedge space, in particular the connected correlators of products of $\mathcal{E}$-operators. The recent study of Hurwitz numbers has often focussed on their structure with fixed genus and varying ramification profile. Our main result is orthogonal to this, allowing for the explicit calculation and the asymptotic analysis of Hurwitz numbers in large genus. We pose the broad question of which other enumerative problems exhibit analogous structure. We prove that orbifold Hurwitz numbers can also be expressed as a linear combination of exponentials and conjecture that monotone Hurwitz numbers share a similar structure, but with the inclusion of an additional linear term., Comment: 18 pages
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- 2024
6. A System and Benchmark for LLM-based Q&A on Heterogeneous Data
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Fokoue, Achille, Jayaraman, Srideepika, Khabiri, Elham, Kephart, Jeffrey O., Li, Yingjie, Shah, Dhruv, Drissi, Youssef, Heath III, Fenno F., Bhamidipaty, Anu, Tipu, Fateh A., and Baseman, Robert J.
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Computer Science - Databases ,Computer Science - Artificial Intelligence - Abstract
In many industrial settings, users wish to ask questions whose answers may be found in structured data sources such as a spreadsheets, databases, APIs, or combinations thereof. Often, the user doesn't know how to identify or access the right data source. This problem is compounded even further if multiple (and potentially siloed) data sources must be assembled to derive the answer. Recently, various Text-to-SQL applications that leverage Large Language Models (LLMs) have addressed some of these problems by enabling users to ask questions in natural language. However, these applications remain impractical in realistic industrial settings because they fail to cope with the data source heterogeneity that typifies such environments. In this paper, we address heterogeneity by introducing the siwarex platform, which enables seamless natural language access to both databases and APIs. To demonstrate the effectiveness of siwarex, we extend the popular Spider dataset and benchmark by replacing some of its tables by data retrieval APIs. We find that siwarex does a good job of coping with data source heterogeneity. Our modified Spider benchmark will soon be available to the research community
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- 2024
7. Towards Fast Rates for Federated and Multi-Task Reinforcement Learning
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Zhu, Feng, Heath Jr., Robert W., and Mitra, Aritra
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Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
We consider a setting involving $N$ agents, where each agent interacts with an environment modeled as a Markov Decision Process (MDP). The agents' MDPs differ in their reward functions, capturing heterogeneous objectives/tasks. The collective goal of the agents is to communicate intermittently via a central server to find a policy that maximizes the average of long-term cumulative rewards across environments. The limited existing work on this topic either only provide asymptotic rates, or generate biased policies, or fail to establish any benefits of collaboration. In response, we propose Fast-FedPG - a novel federated policy gradient algorithm with a carefully designed bias-correction mechanism. Under a gradient-domination condition, we prove that our algorithm guarantees (i) fast linear convergence with exact gradients, and (ii) sub-linear rates that enjoy a linear speedup w.r.t. the number of agents with noisy, truncated policy gradients. Notably, in each case, the convergence is to a globally optimal policy with no heterogeneity-induced bias. In the absence of gradient-domination, we establish convergence to a first-order stationary point at a rate that continues to benefit from collaboration., Comment: Accepted to the Decision and Control Conference (CDC), 2024
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- 2024
8. Online Ramsey numbers of ordered graphs
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Heath, Emily, King, Dylan, McCourt, Grace, Sheats, Hannah, and Wisby, Justin
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Mathematics - Combinatorics ,05D10 - Abstract
The online ordered Ramsey game is played between two players, Builder and Painter, on an infinite sequence of vertices with ordered graphs $(G_1,G_2)$, which have linear orderings on their vertices. On each turn, Builder first selects an edge before Painter colors it red or blue. Builder's objective is to construct either an ordered red copy of $G_1$ or an ordered blue copy of $G_2$, while Painter's objective is to delay this for as many turns as possible. The online ordered Ramsey number $r_o(G_1,G_2)$ is the number of turns Builder takes to win in the case that both players play optimally. Few lower bounds are known for this quantity. In this paper, we introduce a succinct proof of a new lower bound based on the maximum left- and right-degrees in the ordered graphs. We also upper bound $r_o(G_1,G_2)$ in two cases: when $G_1$ is a cycle and $G_2$ a complete bipartite graph, and when $G_1$ is a tree and $G_2$ a clique., Comment: 8 pages
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- 2024
9. You've Got Mail: A Technology-Mediated Feedback Strategy to Support Self-Regulated Learning in First-Year University Students
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Isabella Sauchelli, Georgina Heath, Amanda Richardson, Sally Lewis, and Lisa-Angelique Lim
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Self-regulated learning (SRL) is associated with university student academic success outcomes, however students often need support to develop these skills. Technology-mediated feedback is one strategy that may aid educators in supporting students' SRL development. This study aims to explore whether a technology-mediated feedback strategy targeting tutorial preparation for flipped classrooms enhances first-year students' self-report SRL and observed implementation of the strategy. Self-report SRL was measured using the Motivated Strategies for Learning Questionnaire (MSLQ); strategy implementation profiles were based on lecture video access patterns. First-year psychology students (n = 99) were sent technology-mediated feedback emails aimed at developing their SRL. Paired-samples t-tests revealed significant increases in post-intervention self-reported motivational SRL subscales; self-reported and observed learning strategies implementation did not improve. Future research could build upon this exploratory work to form a multi-pronged strategy to increase understanding of the role of technology-mediated feedback in first-year students' SRL development for flipped classroom learning.
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- 2024
10. Looking Inward: Academic Advisors' Mental Health
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Krista M. Soria, Elise Kokenge, Cassandra A. Heath, Erin C. Standley, Shannon J. F. Wilson, Jacob R. Connley, and Aaron I. Agramon
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We examined academic advisors' clinically significant symptoms of major depressive disorder (MDD) and generalized anxiety disorder (GAD), including whether there are statistically significant relationships between advisors' demographic characteristics, work-related variables, institutional variables, burnout, resilience, and risk of clinically significant MDD/GAD symptoms. We analyzed survey data of academic advisors collected from February to March 2023 (n = 777) and found that 16.9% of advisors met the criteria for MDD while 29.6% met the criteria for GAD, rates higher than national averages. While there were some demographic differences, advisors who experienced higher rates of burnout had increased odds of experiencing MDD and GAD symptoms. In addition, advisors' resilience was associated with decreased odds of experiencing MDD and GAD symptoms.
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- 2024
11. Rare variant contribution to the heritability of coronary artery disease.
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Rocheleau, Ghislain, Clarke, Shoa, Auguste, Gaëlle, Hasbani, Natalie, Morrison, Alanna, Heath, Adam, Bielak, Lawrence, Iyer, Kruthika, Young, Erica, Stitziel, Nathan, Jun, Goo, Laurie, Cecelia, Broome, Jai, Khan, Alyna, Arnett, Donna, Becker, Lewis, Bis, Joshua, Boerwinkle, Eric, Bowden, Donald, Carson, April, Ellinor, Patrick, Fornage, Myriam, Franceschini, Nora, Freedman, Barry, Heard-Costa, Nancy, Hou, Lifang, Chen, Yii-Der, Kenny, Eimear, Kooperberg, Charles, Kral, Brian, Loos, Ruth, Lutz, Sharon, Manson, JoAnn, Martin, Lisa, Mitchell, Braxton, Nassir, Rami, Palmer, Nicholette, Post, Wendy, Preuss, Michael, Psaty, Bruce, Raffield, Laura, Regan, Elizabeth, Rich, Stephen, Smith, Jennifer, Taylor, Kent, Yanek, Lisa, Young, Kendra, Hilliard, Austin, Tcheandjieu, Catherine, Peyser, Patricia, Vasan, Ramachandran, Rotter, Jerome, Miller, Clint, Assimes, Themistocles, de Vries, Paul, and Do, Ron
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Humans ,Coronary Artery Disease ,Genetic Predisposition to Disease ,Linkage Disequilibrium ,Polymorphism ,Single Nucleotide ,Male ,Female ,Gene Frequency ,Genome-Wide Association Study ,White People ,Case-Control Studies ,Whole Genome Sequencing ,Genetic Variation ,Middle Aged - Abstract
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of European ancestry from the NHLBI TOPMed program. We estimate CAD heritability at 34.3% assuming a prevalence of 8.2%. Ultra-rare (minor allele frequency ≤ 0.1%) variants with low linkage disequilibrium (LD) score contribute ~50% of the heritability. We also investigate CAD heritability enrichment using a diverse set of functional annotations: i) constraint; ii) predicted protein-altering impact; iii) cis-regulatory elements from a cell-specific chromatin atlas of the human coronary; and iv) annotation principal components representing a wide range of functional processes. We observe marked enrichment of CAD heritability for most functional annotations. These results reveal the predominant role of ultra-rare variants in low LD on the heritability of CAD. Moreover, they highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.
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- 2024
12. Digital Financial Services and Women’s Empowerment: Experimental Evidence from Tanzania
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Heath, Rachel and Riley, Emma
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Technological Change: Choices and Consequences • Diffusion Processes ,Household Production and Intrahousehold Allocation ,Microeconomic Analyses of Economic Development ,Economics of Gender • Non-labor Discrimination ,Tanzania - Abstract
Can increasing women’s use of digital financial services raise their empowerment? We test this hypothesis using a randomized control trial with 152 female microfinance groups in Tanzania, where treated groups were randomly switched to repay their loan using mobile money instead of cash. This exogenous shift in women’s use of mobile money for loan repayment substantially increases their use for other types of transactions. Women’s control over their finances increases, they have higher levels of empowerment in the household and expenditures shift towards goods plausibly aligned with their preferences. These findings highlight the benefits of greater use of digital technologies for women.
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- 2024
13. Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons
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Fugón, Orangel J Gutierrez, Sharifi, Osman, Heath, Nicholas, Soto, Daniela C, Gomez, J Antonio, Yasui, Dag H, Mendiola, Aron Judd P, O’Geen, Henriette, Beitnere, Ulrika, Tomkova, Marketa, Haghani, Viktoria, Dillon, Greg, Segal, David J, and LaSalle, Janine M
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Biological Sciences ,Genetics ,Intellectual and Developmental Disabilities (IDD) ,Stem Cell Research - Induced Pluripotent Stem Cell ,Rare Diseases ,Stem Cell Research ,Pediatric ,Human Genome ,Neurosciences ,Brain Disorders ,1.1 Normal biological development and functioning ,Generic health relevance ,Humans ,Genomic Imprinting ,CCCTC-Binding Factor ,Chromosomes ,Human ,Pair 15 ,Neurons ,DNA Methylation ,Transcriptome ,Ubiquitin-Protein Ligases ,Cell Differentiation ,Angelman Syndrome ,RNA ,Long Noncoding ,Prader-Willi Syndrome ,snRNP Core Proteins ,Alleles ,Cell Line ,Epigenome ,chromatin ,imprinting ,human cell models ,Angelman ,LUHMES ,methylation ,UBE3A ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Human cell line models, including the neuronal precursor line LUHMES, are important for investigating developmental transcriptional dynamics within imprinted regions, particularly the 15q11-q13 Angelman (AS) and Prader-Willi (PWS) syndrome locus. AS results from loss of maternal UBE3A in neurons, where the paternal allele is silenced by a convergent antisense transcript UBE3A-ATS, a lncRNA that terminates at PWAR1 in non-neurons. qRT-PCR analysis confirmed the exclusive and progressive increase in UBE3A-ATS in differentiating LUHMES neurons, validating their use for studying UBE3A silencing. Genome-wide transcriptome analyses revealed changes to 11 834 genes during neuronal differentiation, including the upregulation of most genes within the 15q11-q13 locus. To identify dynamic changes in chromatin loops linked to transcriptional activity, we performed a HiChIP validated by 4C, which identified two neuron-specific CTCF loops between MAGEL2-SNRPN and PWAR1-UBE3A. To determine if allele-specific differentially methylated regions (DMR) may be associated with CTCF loop anchors, whole genome long-read nanopore sequencing was performed. We identified a paternally hypomethylated DMR near the SNRPN upstream loop anchor exclusive to neurons and a paternally hypermethylated DMR near the PWAR1 CTCF anchor exclusive to undifferentiated cells, consistent with increases in neuronal transcription. Additionally, DMRs near CTCF loop anchors were observed in both cell types, indicative of allele-specific differences in chromatin loops regulating imprinted transcription. These results provide an integrated view of the 15q11-q13 epigenetic landscape during LUHMES neuronal differentiation, underscoring the complex interplay of transcription, chromatin looping, and DNA methylation. They also provide insights for future therapeutic approaches for AS and PWS.
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- 2024
14. Rethinking Molecular Design: Integrating Latent Variable and Auto-Regressive Models for Goal Directed Generation
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Arthur-Loui, Heath, Mollaysa, Amina, and Krauthammer, Michael
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Quantitative Biology - Biomolecules ,Computer Science - Machine Learning - Abstract
De novo molecule design has become a highly active research area, advanced significantly through the use of state-of-the-art generative models. Despite these advances, several fundamental questions remain unanswered as the field increasingly focuses on more complex generative models and sophisticated molecular representations as an answer to the challenges of drug design. In this paper, we return to the simplest representation of molecules, and investigate overlooked limitations of classical generative approaches, particularly Variational Autoencoders (VAEs) and auto-regressive models. We propose a hybrid model in the form of a novel regularizer that leverages the strengths of both to improve validity, conditional generation, and style transfer of molecular sequences. Additionally, we provide an in depth discussion of overlooked assumptions of these models' behaviour.
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- 2024
15. The UNCOVER Survey: First Release of Ultradeep JWST/NIRSpec PRISM spectra for ~700 galaxies from z~0.3-13 in Abell 2744
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Price, Sedona H., Bezanson, Rachel, Labbe, Ivo, Furtak, Lukas J., de Graaff, Anna, Greene, Jenny E., Kokorev, Vasily, Setton, David J., Suess, Katherine A., Brammer, Gabriel, Cutler, Sam E., Leja, Joel, Pan, Richard, Wang, Bingjie, Weaver, John R., Whitaker, Katherine E., Atek, Hakim, Burgasser, Adam J., Chemerynska, Iryna, Dayal, Pratika, Feldmann, Robert, Schreiber, Natascha M. Förster, Fudamoto, Yoshinobu, Fujimoto, Seiji, Glazebrook, Karl, Goulding, Andy D., Khullar, Gourav, Kriek, Mariska, Marchesini, Danilo, Maseda, Michael V., Miller, Tim B., Muzzin, Adam, Nanayakkara, Themiya, Nelson, Erica, Oesch, Pascal A., Shipley, Heath, Smit, Renske, Taylor, Edward N., van Dokkum, Pieter, Williams, Christina C., and Zitrin, Adi
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the design and observations of low resolution JWST/NIRSpec PRISM spectroscopy from the Ultradeep NIRSpec and NIRCam ObserVations before the Epoch of Reionization (UNCOVER) Cycle 1 JWST Treasury program. Targets are selected using JWST/NIRCam photometry from UNCOVER and other programs, and cover a wide range of categories and redshifts to ensure the legacy value of the survey. These categories include the first galaxies at $z\gtrsim10$, faint galaxies during the Epoch of Reionization ($z\sim6-8$), high redshift AGN ($z\gtrsim6$), Population III star candidates, distant quiescent and dusty galaxies ($1\lesssim z \lesssim 6$), and filler galaxies sampling redshift--color--magnitude space from $z\sim 0.1-13$. Seven NIRSpec MSA masks across the extended Abell 2744 cluster were observed, along with NIRCam parallel imaging in 8 filters (F090W, F115W, F150W, F200W, F277W, F356W, F410M, F444W, F480M) over a total area of ~26 arcmin$^2$, overlapping existing HST coverage from programs including the Hubble Frontier Fields and BUFFALO. We successfully observed 553 objects down to $m_{\mathrm{F444W}}\sim30\mathrm{AB}$, and by leveraging mask overlaps, we reach total on-target exposure times ranging from 2.4-16.7h. We demonstrate the success rate and distribution of confirmed redshifts, and also highlight the rich information revealed by these ultradeep spectra for a subset of our targets. An updated lens model of Abell 2744 is also presented, including 14 additional spectroscopic redshifts and finding a total cluster mass of $M_{\mathrm{SL}}=(2.1\pm0.3)\times10^{15}\,\mathrm{M}_{\odot}$. We publicly release reduced 1D and 2D spectra for all objects observed in Summer 2023 along with a spectroscopic redshift catalog and the updated lens model of the cluster (https://jwst-uncover.github.io/DR4.html)., Comment: 19 pages, 9 figures, 4 tables, submitted to ApJ, comments welcome! Data available at: https://jwst-uncover.github.io/DR4.html (v2: figure format correction)
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- 2024
16. Universal scaling relations in electron-phonon superconductors
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Heath, Joshuah T. and Boyack, Rufus
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Condensed Matter - Superconductivity - Abstract
We study linear scaling relations in electron-phonon superconductors. By combining numerical and analytical techniques, we find linear Homes scaling relations between the zero-temperature superfluid density and the normal-state DC conductivity. This is due to Galilean invariance being broken, either via a large impurity scattering rate or inelastic scattering of electrons and Einstein phonons at large electron-phonon coupling. Our work thus shows that Homes scaling is more universal than either cuprate or BCS-like physics, and is instead a fundamental result in a wide class of superconductors., Comment: Main article: 7 pages, 3 figures. Supplemental material: 32 pages, 14 figures
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- 2024
17. Bulge+disc decomposition of HFF and CANDELS galaxies: UVJ diagrams and stellar mass-size relations of galaxy components at $0.2 \leq z \leq 1.5$
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Nedkova, Kalina V., Häußler, Boris, Marchesini, Danilo, Brammer, Gabriel B., Feinstein, Adina D., Johnston, Evelyn J., Kartaltepe, Jeyhan S., Koekemoer, Anton M., Martis, Nicholas S., Muzzin, Adam, Rafelski, Marc, Shipley, Heath V., Skelton, Rosalind E., Stefanon, Mauro, van der Wel, Arjen, and Whitaker, Katherine E.
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Astrophysics - Astrophysics of Galaxies - Abstract
Using deep imaging from the CANDELS and HFF surveys, we present bulge+disc decompositions with GalfitM for $\sim$17,000 galaxies over $0.2 \leq z\leq 1.5$. We use various model parameters to select reliable samples of discs and bulges, and derive their stellar masses using an empirically calibrated relation between mass-to-light ratio and colour. Across our entire redshift range, we show that discs follow stellar mass-size relations that are consistent with those of star-forming galaxies, suggesting that discs primarily evolve via star formation. In contrast, the stellar mass-size relations of bulges are mass-independent. Our novel dataset further enables us to separate components into star-forming and quiescent based on their specific star formation rates. We find that both star-forming discs and star-forming bulges lie on stellar mass-size relations that are similar to those of star-forming galaxies, while quiescent discs are typically smaller than star-forming discs and lie on steeper relations, implying distinct evolutionary mechanisms. Similar to quiescent galaxies, quiescent bulges show a flattening in the stellar mass-size relation at $\sim$10$^{10}$M$_\odot$, below which they show little mass dependence. However, their best-fitting relations have lower normalisations, indicating that at a given mass, bulges are smaller than quiescent galaxies. Finally, we obtain rest-frame colours for individual components, showing that bulges typically have redder colours than discs, as expected. We visually derive UVJ criteria to separate star-forming and quiescent components and show that this separation agrees well with component colour. HFF bulge+disc decomposition catalogues used for these analyses are publicly released with this paper., Comment: 30 pages, 18 figures, and 6 tables. Resubmitted to MNRAS after addressing a thorough and constructive referee report
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- 2024
18. First detection of coherent elastic neutrino-nucleus scattering on germanium
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Adamski, S., Ahn, M., Barbeau, P. S., Belov, V., Bernardi, I., Bock, C., Bolozdynya, A., Bouabid, R., Browning, J., Cabrera-Palmer, B., Cedarblade-Jones, N., Rivera, J. Colón, Conley, E., da Silva, V., Daughhetee, J., Detwiler, J., Ding, K., Durand, M. R., Efremenko, Y., Elliott, S. R., Erlandson, A., Fabris, L., Galindo-Uribarri, A., Green, M. P., Hakenmüller, J., Heath, M. R., Hedges, S., Jeong, H., Johnson, B. A., Johnson, T., Jones, H., Khromov, A., Konovalov, A., Kozlova, E., Kumpan, A., Kyzylova, O., Lee, Y., Li, G., Li, L., Link, J. M., Liu, J., Luxnat, M., Major, A., Mann, K., Markoff, D. M., Mattingly, J., Moye, J., Mueller, P. E., Newby, J., Ogoi, N., O'Reilly, J., Parno, D. S., Pérez-Loureiro, D., Pershey, D., Prior, C. G., Queen, J., Rapp, R., Ray, H., Razuvaeva, O., Reyna, D., Rich, G. C., Rudik, D., Runge, J., Salvat, D. J., Sander, J., Scholberg, K., Shakirov, A., Simakov, G., Snow, W. M., Sosnovtsev, V., Stringer, M., Subedi, T., Suh, B., Sur, B., Tayloe, R., Tellez-Giron-Flores, K., Tsai, Y. -T., van Nieuwenhuizen, E. E., Virtue, C. J., Visser, G., Walkup, K., Ward, E. M., Wongjirad, T., Yang, Y., Yoo, J., Yu, C. -H., and Zaalishvili, A.
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High Energy Physics - Experiment - Abstract
We report the first detection of coherent elastic neutrino-nucleus scattering (CEvNS) on germanium, measured at the Spallation Neutron Source at Oak Ridge National Laboratory. The Ge-Mini detector of the COHERENT collaboration employs large-mass, low-noise, high-purity germanium spectrometers, enabling excellent energy resolution, and an analysis threshold of 1.5 keV electron-equivalent ionization energy. We observe a on-beam excess of 20.6$_{+7.1}^{-6.3}$ counts with a total exposure of 10.22 GWhkg and we reject the no-CEvNS hypothesis with 3.9 sigma significance. The result agrees with the predicted standard model of particle physics signal rate within 2 sigma., Comment: 7 pages, 5 figures
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- 2024
19. Harnessing Multimodal Sensing for Multi-user Beamforming in mmWave Systems
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Patel, Kartik and Heath Jr, Robert W.
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Electrical Engineering and Systems Science - Signal Processing - Abstract
Sensor-aided beamforming reduces the overheads associated with beam training in millimeter-wave (mmWave) multi-input-multi-output (MIMO) communication systems. Most prior work, though, neglects the challenges associated with establishing multi-user (MU) communication links in mmWave MIMO systems. In this paper, we propose a new framework for sensor-aided beam training in MU mmWave MIMO system. We leverage the beamspace representation of the channel that contains only the angles-of-departure (AoDs) of the channel's significant multipath components. We show that a deep neural network (DNN)-based multimodal sensor fusion framework can estimate the beamspace representation of the channel using sensor data. To aid the DNN training, we introduce a novel supervised soft-contrastive loss (SSCL) function that leverages the inherent similarity between channels to extract similar features from the sensor data for similar channels. Finally, we design an MU beamforming strategy that uses the estimated beamspaces of the channels to select analog precoders for all users in a way that prevents transmission to multiple users over the same directions. Compared to the baseline, our approach achieves more than 4$\times$ improvement in the median sum-spectral efficiency (SE) at 42 dBm equivalent isotropic radiated power (EIRP) with 4 active users. This demonstrates that sensor data can provide more channel information than previously explored, with significant implications for machine learning (ML)-based communication and sensing systems.
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- 2024
20. 'Who, When, How to Share': Pilot Study of a New Disclosure Decision-Making Programme for Autistic Adults
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Emeline Han, Katrina Scior, Kana Grace, Eric Heath, Simone Dufresne, and Laura Crane
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In this pilot study, we report on the feasibility, acceptability and potential impact of 'Who, When, How to Share', a new disclosure decision-making programme for autistic adults. We evaluated this programme using pre-post mixed-methods surveys that included questions about participants' experiences of the programme and four psychosocial outcome measures. While 32 autistic adults completed the pre-programme survey and enrolled into the programme, there was high attrition, with only 19 autistic adults completing the programme and post-programme survey. We found that it was feasible to deliver the programme in a guided self-help format, although a minority of participants (who completed the programme or provided reasons for withdrawing from the programme) found it challenging to work through the programme independently and within the study time frame. High levels of satisfaction and positive qualitative feedback also suggested that the programme was acceptable to autistic adults. Participants provided useful recommendations for improvement, such as more interactive elements to enhance engagement. The programme showed potential to improve decisional conflict, disclosure-related distress, stigma-related stress and internalised stigma among autistic adults, though further evaluation of the impact of the programme is needed.
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- 2024
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21. The Essence of Giving—A Transplant Story
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Heath, Andy
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- 2018
- Full Text
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22. Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight.
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Kakouridis, Anne, Diamond, Spencer, Eng, Thomas, Mills, Heath J, Gámez Holzhaus, Olivia, Summers, Michael L, Garcia-Pichel, Ferran, and Mukhopadhyay, Aindrila
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Biological Sciences ,Industrial Biotechnology ,Genetics ,Cyanobacteria ,InternationalSpace Station ,Nostoc punctiforme ,Space Flight ,Space Travel ,International Space Station ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Biomedical Engineering ,Biochemistry and cell biology ,Bioinformatics and computational biology - Abstract
Effective transport of biological systems as cargo during space travel is a critical requirement to use synthetic biology and biomanufacturing in outer space. Bioproduction using microbes will drive the extent to which many human needs can be met in environments with limited resources. Vast repositories of biological parts and strains are available to meet this need, but their on-site availability requires effective transport. Here, we explore an approach that allows DNA plasmids, ubiquitous synthetic biology parts, to be safely transported to the International Space Station and back to the Kennedy Space Center without low-temperature or cryogenic stowage. Our approach relied on the cyanobacterium Nostoc punctiforme PC73102, which is naturally tolerant to prolonged desiccation. Desiccated N. punctiforme was able to carry the non-native pSCR119 plasmid as intracellular cargo safely to space and back. Upon return to the laboratory, the extracted plasmid showed no DNA damage or additional mutations and could be used as intended to transform the model synbio host Escherichia coli to bestow kanamycin resistance. This proof-of-concept study provides the foundation for a ruggedized transport host for DNA to environments where there is a need to reduce equipment and infrastructure for biological parts stowage and storage.
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- 2024
23. Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins
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Fote, Gianna M, Eapen, Vinay V, Lim, Ryan G, Yu, Clinton, Salazar, Lisa, McClure, Nicolette R, McKnight, Jharrayne, Nguyen, Thai B, Heath, Marie C, Lau, Alice L, Villamil, Mark A, Miramontes, Ricardo, Kratter, Ian H, Finkbeiner, Steven, Reidling, Jack C, Paulo, Joao A, Kaiser, Peter, Huang, Lan, Housman, David E, Thompson, Leslie M, and Steffan, Joan S
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Biochemistry and Cell Biology ,Biological Sciences ,Rare Diseases ,Neurosciences ,Brain Disorders ,Genetics ,Orphan Drug ,Neurodegenerative ,Huntington's Disease ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Neurological ,Huntingtin Protein ,Lysosomes ,RNA-Binding Proteins ,Humans ,Ubiquitin ,Mitochondria ,Autophagy ,Animals ,Mitochondrial Proteins ,Mice ,Protein Binding ,Huntington Disease ,Peptides ,Huntingtin ,RNA-binding proteins ,autophagy ,ubiquitin ,ubiquitin-binding domain - Abstract
Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in the HTT gene, encoding an expanded polyglutamine (polyQ) repeat within the HTT protein, causes HD and may compromise HTT's normal activity contributing to HD pathology. Here, we investigated the previously defined role of HTT in autophagy specifically through studying HTT's association with ubiquitin. We find that HTT interacts directly with ubiquitin in vitro. Tandem affinity purification was used to identify ubiquitinated and ubiquitin-associated proteins that copurify with a HTT N-terminal fragment under basal conditions. Copurification is enhanced by HTT polyQ expansion and reduced by mimicking HTT serine 421 phosphorylation. The identified HTT-interacting proteins include RNA-binding proteins (RBPs) involved in mRNA translation, proteins enriched in stress granules, the nuclear proteome, the defective ribosomal products (DRiPs) proteome and the brain-derived autophagosomal proteome. To determine whether the proteins interacting with HTT are autophagic targets, HTT knockout (KO) cells and immunoprecipitation of lysosomes were used to investigate autophagy in the absence of HTT. HTT KO was associated with reduced abundance of mitochondrial proteins in the lysosome, indicating a potential compromise in basal mitophagy, and increased lysosomal abundance of RBPs which may result from compensatory up-regulation of starvation-induced macroautophagy. We suggest HTT is critical for appropriate basal clearance of mitochondrial proteins and RBPs, hence reduced HTT proteostatic function with mutation may contribute to the neuropathology of HD.
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- 2024
24. Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.
- Author
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Kennedy, Eamonn, Liebel, Spencer, Lindsey, Hannah, Vadlamani, Shashank, Lei, Pui-Wa, Adamson, Maheen, Alda, Martin, Alonso-Lana, Silvia, Anderson, Tim, Arango, Celso, Asarnow, Robert, Avram, Mihai, Ayesa-Arriola, Rosa, Babikian, Talin, Banaj, Nerisa, Bird, Laura, Borgwardt, Stefan, Brodtmann, Amy, Brosch, Katharina, Caeyenberghs, Karen, Calhoun, Vince, Chiaravalloti, Nancy, Cifu, David, Crespo-Facorro, Benedicto, Dalrymple-Alford, John, Dams-OConnor, Kristen, Dannlowski, Udo, Darby, David, Davenport, Nicholas, DeLuca, John, Diaz-Caneja, Covadonga, Disner, Seth, Dobryakova, Ekaterina, Ehrlich, Stefan, Esopenko, Carrie, Ferrarelli, Fabio, Frank, Lea, Franz, Carol, Fuentes-Claramonte, Paola, Genova, Helen, Giza, Christopher, Goltermann, Janik, Grotegerd, Dominik, Gruber, Marius, Gutierrez-Zotes, Alfonso, Ha, Minji, Haavik, Jan, Hinkin, Charles, Hoskinson, Kristen, Hubl, Daniela, Irimia, Andrei, Jansen, Andreas, Kaess, Michael, Kang, Xiaojian, Kenney, Kimbra, Keřková, Barbora, Khlif, Mohamed, Kim, Minah, Kindler, Jochen, Kircher, Tilo, Knížková, Karolina, Kolskår, Knut, Krch, Denise, Kremen, William, Kuhn, Taylor, Kumari, Veena, Kwon, Junsoo, Langella, Roberto, Laskowitz, Sarah, Lee, Jungha, Lengenfelder, Jean, Liou-Johnson, Victoria, Lippa, Sara, Løvstad, Marianne, Lundervold, Astri, Marotta, Cassandra, Marquardt, Craig, Mattos, Paulo, Mayeli, Ahmad, McDonald, Carrie, Meinert, Susanne, Melzer, Tracy, Merchán-Naranjo, Jessica, Michel, Chantal, Morey, Rajendra, Mwangi, Benson, Myall, Daniel, Nenadić, Igor, Newsome, Mary, Nunes, Abraham, OBrien, Terence, Oertel, Viola, Ollinger, John, Olsen, Alexander, Ortiz García de la Foz, Victor, Ozmen, Mustafa, Pardoe, Heath, Parent, Marise, Piras, Fabrizio, and Piras, Federica
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Parkinson’s disease ,attention-deficit/hyperactivity disorder ,bipolar disorder ,dementia ,depression ,memory ,schizophrenia ,stroke ,traumatic brain injury ,verbal learning - Abstract
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinsons disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest models identified age, years of education, and site as important VLM covariates. A Bayesian harmonization approach was used to isolate and remove site effects. Regression estimated the adjusted association of each clinical group with VLM scores. Memory deficits were strongly associated with dementia and schizophrenia (p < 0.001), while neither depression nor ADHD showed consistent associations with VLM scores (p > 0.05). Differences associated with clinical conditions were larger for longer delayed recall duration items. By comparing VLM across clinical conditions, this study provides a foundation for enhanced diagnostic precision and offers new insights into disease management of comorbid disorders.
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- 2024
25. A collection of cancellative, right LCM, not group-embeddable monoids
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Edwardes, Milo and Heath, Daniel
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Mathematics - Rings and Algebras ,Mathematics - Operator Algebras ,20M10 - Abstract
By classical results of Malcev, cancellative monoids need not be group-embeddable. In this paper, we describe and give presentations for and study an infinite family $\mathcal{M}_n$ of cancellative monoids which are not group-embeddable, originating from Malcev's original work. We show that $\mathcal{M}_n$ is right LCM for $n \geq 2$, owing to applications in the study of $\mathrm{C}^*$-algebras by Brix, Bruce and Dor-On. We finish by showing that $\mathcal{M}_1$ is not right LCM, but is $2$-aligned., Comment: 10 pages
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- 2024
26. Bayesian Joint Modeling for Longitudinal Magnitude Data with Informative Dropout: an Application to Critical Care Data
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Teng, Wen, Ferguson, Niall D., Goligher, Ewan C., and Heath, Anna
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Statistics - Methodology ,Statistics - Applications - Abstract
In various biomedical studies, the focus of analysis centers on the magnitudes of data, particularly when algebraic signs are irrelevant or lost. To analyze the magnitude outcomes in repeated measures studies, using models with random effects is essential. This is because random effects can account for individual heterogeneity, enhancing parameter estimation precision. However, there are currently no established regression methods that incorporate random effects and are specifically designed for magnitude outcomes. This article bridges this gap by introducing Bayesian regression modeling approaches for analyzing magnitude data, with a key focus on the incorporation of random effects. Additionally, the proposed method is extended to address multiple causes of informative dropout, commonly encountered in repeated measures studies. To tackle the missing data challenge arising from dropout, a joint modeling strategy is developed, building upon the previously introduced regression techniques. Two numerical simulation studies are conducted to assess the validity of our method. The chosen simulation scenarios aim to resemble the conditions of our motivating study. The results demonstrate that the proposed method for magnitude data exhibits good performance in terms of both estimation accuracy and precision, and the joint models effectively mitigate bias due to missing data. Finally, we apply proposed models to analyze the magnitude data from the motivating study, investigating if sex impacts the magnitude change in diaphragm thickness over time for ICU patients.
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- 2024
27. Generalized Ramsey numbers of cycles, paths, and hypergraphs
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Bal, Deepak, Bennett, Patrick, Heath, Emily, and Zerbib, Shira
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Mathematics - Combinatorics - Abstract
Given a $k$-uniform hypergraph $G$ and a set of $k$-uniform hypergraphs $\mathcal{H}$, the generalized Ramsey number $f(G,\mathcal{H},q)$ is the minimum number of colors needed to edge-color $G$ so that every copy of every hypergraph $H\in \mathcal{H}$ in $G$ receives at least $q$ different colors. In this note we obtain bounds, some asymptotically sharp, on several generalized Ramsey numbers, when $G=K_n$ or $G=K_{n,n}$ and $\mathcal{H}$ is a set of cycles or paths, and when $G=K_n^k$ and $\mathcal{H}$ contains a clique on $k+2$ vertices or a tight cycle.
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- 2024
28. Next-slot OFDM-CSI Prediction: Multi-head Self-attention or State Space Model?
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Akrout, Mohamed, Bellili, Faouzi, Mezghani, Amine, and Heath, Robert W.
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
The ongoing fifth-generation (5G) standardization is exploring the use of deep learning (DL) methods to enhance the new radio (NR) interface. Both in academia and industry, researchers are investigating the performance and complexity of multiple DL architecture candidates for specific one-sided and two-sided use cases such as channel state estimation (CSI) feedback, CSI prediction, beam management, and positioning. In this paper, we set focus on the CSI prediction task and study the performance and generalization of the two main DL layers that are being extensively benchmarked within the DL community, namely, multi-head self-attention (MSA) and state-space model (SSM). We train and evaluate MSA and SSM layers to predict the next slot for uplink and downlink communication scenarios over urban microcell (UMi) and urban macrocell (UMa) OFDM 5G channel models. Our numerical results demonstrate that SSMs exhibit better prediction and generalization capabilities than MSAs only for SISO cases. For MIMO scenarios, however, the MSA layer outperforms the SSM one. While both layers represent potential DL architectures for future DL-enabled 5G use cases, the overall investigation of this paper favors MSAs over SSMs.
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- 2024
29. Pretzel monoids
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Heath, Daniel, Kambites, Mark, and Szakács, Nóra
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Mathematics - Rings and Algebras ,20M10 - Abstract
We introduce an interesting class of left adequate monoids which we call pretzel monoids. These, on the one hand, are monoids of birooted graphs with respect to a natural `glue-and-fold' operation, and on the other hand, are shown to be defined in the category of left adequate monoids by a natural class of presentations. They are also shown to be the free idempotent-pure expansions of right cancellative monoids, making them, in some sense, the left adequate analogues of Margolis-Meakin expansions for inverse monoids. The construction recovers the second author's geometric model of free left adequate monoids when the right cancellative monoid is free., Comment: 34 pages, 10 figures
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- 2024
30. Medium Bands, Mega Science: a JWST/NIRCam Medium-Band Imaging Survey of Abell 2744
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Suess, Katherine A., Weaver, John R., Price, Sedona H., Pan, Richard, Wang, Bingjie, Bezanson, Rachel, Brammer, Gabriel, Cutler, Sam E., Labbe, Ivo, Leja, Joel, Williams, Christina C., Whitaker, Katherine E., Dayal, Pratika, de Graaff, Anna, Feldmann, Robert, Franx, Marijn, Fudamoto, Yoshinobu, Fujimoto, Seiji, Furtak, Lukas J., Goulding, Andy D., Greene, Jenny E., Khullar, Gourav, Kokorev, Vasily, Kriek, Mariska, Lorenz, Brian, Marchesini, Danilo, Maseda, Michael V., Matthee, Jorryt, Miller, Tim B., Mitsuhashi, Ikki, Mowla, Lamiya A., Muzzin, Adam, Naidu, Rohan P., Nanayakkara, Themiya, Nelson, Erica J., Oesch, Pascal A., Setton, David J., Shipley, Heath, Smit, Renske, Spilker, Justin S., van Dokkum, Pieter, and Zitrin, Adi
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Astrophysics - Astrophysics of Galaxies - Abstract
In this paper, we describe the "Medium Bands, Mega Science" JWST Cycle 2 survey (JWST-GO-4111) and demonstrate the power of these data to reveal both the spatially-integrated and spatially-resolved properties of galaxies from the local universe to the era of cosmic dawn. Executed in November 2023, MegaScience obtained ~30 arcmin^2 of deep multiband NIRCam imaging centered on the z~0.3 Abell 2744 cluster, including eleven medium-band filters and the two shortest-wavelength broad-band filters, F070W and F090W. Together, MegaScience and the UNCOVER Cycle 1 treasury program provide a complete set of deep (~28-30 mag) images in all NIRCam medium- and broad-band filters. This unique dataset allows us to precisely constrain photometric redshifts, map stellar populations and dust attenuation for large samples of distant galaxies, and examine the connection between galaxy structures and formation histories. MegaScience also includes ~17 arcmin^2 of NIRISS parallel imaging in two broad-band and four medium-band filters from 0.9-4.8um, expanding the footprint where robust spectral energy distribution (SED) fitting is possible. We provide example SEDs and multi-band cutouts at a variety of redshifts, and use a catalog of JWST spectroscopic redshifts to show that MegaScience improves both the scatter and catastrophic outlier rate of photometric redshifts by factors of 2-3. Additionally, we demonstrate the spatially-resolved science enabled by MegaScience by presenting maps of the [OIII] line emission and continuum emission in three spectroscopically-confirmed z>6 galaxies. We show that line emission in reionization-era galaxies can be clumpy, extended, and spatially offset from continuum emission, implying that galaxy assembly histories are complex even at these early epochs. We publicly release fully reduced mosaics and photometric catalogs for both the NIRCam primary and NIRISS parallel fields., Comment: 21 pages, 10 figures. Fully reduced imaging, photometric catalogs, and photometric redshift fits publicly available at https://jwst-uncover.github.io/megascience/
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- 2024
31. Beam Training in mmWave Vehicular Systems: Machine Learning for Decoupling Beam Selection
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Kilinc, Ibrahim, Dreifuerst, Ryan M., Kim, Junghoon, and Heath Jr, Robert W.
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Machine Learning - Abstract
Codebook-based beam selection is one approach for configuring millimeter wave communication links. The overhead required to reconfigure the transmit and receive beam pair, though, increases in highly dynamic vehicular communication systems. Location information coupled with machine learning (ML) beam recommendation is one way to reduce the overhead of beam pair selection. In this paper, we develop ML-based location-aided approaches to decouple the beam selection between the user equipment (UE) and the base station (BS). We quantify the performance gaps due to decoupling beam selection and also disaggregating the UE's location information from the BS. Our simulation results show that decoupling beam selection with available location information at the BS performs comparable to joint beam pair selection at the BS. Moreover, decoupled beam selection without location closely approaches the performance of beam pair selection at the BS when sufficient beam pairs are swept., Comment: Submitted to IEEE BlackSeaCom 2024, 6 pages, 5 figures
- Published
- 2024
32. Dynamic Interface Printing
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Vidler, Callum, Halwes, Michael, Kolesnik, Kirill, Segeritz, Philipp, Mail, Matthew, Barlow, Anders J., Koehl, Emmanuelle M., Ramakrishnan, Anand, Scott, Daniel J., Heath, Daniel E., Crozier, Kenneth B., and Collins, David J.
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Physics - Applied Physics - Abstract
Additive manufacturing is an expanding multidisciplinary field encompassing applications including medical devices, aerospace components, microfabrication strategies, and artificial organs. Among additive manufacturing approaches, light-based printing technologies, including two-photon polymerization, projection micro stereolithography, and volumetric printing, have garnered significant attention due to their speed, resolution and/or potential applications for biofabrication. In this study, we introduce dynamic interface printing (DIP), a new 3D printing approach that leverages an acoustically modulated, constrained air-liquid boundary to rapidly generate cm-scale three-dimensional structures within tens of seconds. Distinct from volumetric approaches, this process eliminates the need for intricate feedback systems, specialized chemistry, or complex optics while maintaining rapid printing speeds. We demonstrate the versatility of this technique across a broad array of materials and intricate geometries, including those that would be impossible to print via conventional layer-by-layer methods. In doing so, we demonstrate the rapid fabrication of complex structures in-situ, overprinting, structural parallelisation, and biofabrication utility. Moreover, we showcase that the formation of surface waves at this boundary enables enhanced mass transport, material flexibility, and permits three-dimensional particle patterning. We therefore anticipate that this approach will be invaluable for applications where high resolution, scalable throughput, and biocompatible printing is required., Comment: 63 Pages, 4 Figures, 18 Supplementary Figures
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- 2024
33. Multiplier analysis of Lurye systems with power signals
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Heath, William P. and Carrasco, Joaquin
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Electrical Engineering and Systems Science - Systems and Control - Abstract
Multipliers can be used to guarantee both the Lyapunov stability and input-output stability of Lurye systems with time-invariant memoryless slope-restricted nonlinearities. If a dynamic multiplier is used there is no guarantee the closed-loop system has finite incremental gain. It has been suggested in the literature that without this guarantee such a system may be critically sensitive to time-varying exogenous signals including noise. We show that multipliers guarantee the power gain of the system to be bounded and quantifiable. Furthermore power may be measured about an appropriate steady state bias term, provided the multiplier does not require the nonlinearity to be odd. Hence dynamic multipliers can be used to guarantee Lurye systems have low sensitivity to noise, provided other exogenous systems have constant steady state. We illustrate the analysis with an example where the exogenous signal is a power signal with non-zero mean.
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- 2024
34. Neural Codebook Design for Network Beam Management
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Dreifuerst, Ryan M. and Heath Jr, Robert W.
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Artificial Intelligence ,Computer Science - Information Theory ,Computer Science - Networking and Internet Architecture ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Obtaining accurate and timely channel state information (CSI) is a fundamental challenge for large antenna systems. Mobile systems like 5G use a beam management framework that joins the initial access, beamforming, CSI acquisition, and data transmission. The design of codebooks for these stages, however, is challenging due to their interrelationships, varying array sizes, and site-specific channel and user distributions. Furthermore, beam management is often focused on single-sector operations while ignoring the overarching network- and system-level optimization. In this paper, we proposed an end-to-end learned codebook design algorithm, network beamspace learning (NBL), that captures and optimizes codebooks to mitigate interference while maximizing the achievable performance with extremely large hybrid arrays. The proposed algorithm requires limited shared information yet designs codebooks that outperform traditional codebooks by over 10dB in beam alignment and achieve more than 25% improvements in network spectral efficiency., Comment: To be submitted to IEEE Transactions on Wireless Communications
- Published
- 2024
35. AdaBoost-Based Efficient Channel Estimation and Data Detection in One-Bit Massive MIMO
- Author
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Esfandiari, Majdoddin, Vorobyov, Sergiy A., and Heath Jr, Robert W.
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
The use of one-bit analog-to-digital converter (ADC) has been considered as a viable alternative to high resolution counterparts in realizing and commercializing massive multiple-input multiple-output (MIMO) systems. However, the issue of discarding the amplitude information by one-bit quantizers has to be compensated. Thus, carefully tailored methods need to be developed for one-bit channel estimation and data detection as the conventional ones cannot be used. To address these issues, the problems of one-bit channel estimation and data detection for MIMO orthogonal frequency division multiplexing (OFDM) system that operates over uncorrelated frequency selective channels are investigated here. We first develop channel estimators that exploit Gaussian discriminant analysis (GDA) classifier and approximated versions of it as the so-called weak classifiers in an adaptive boosting (AdaBoost) approach. Particularly, the combination of the approximated GDA classifiers with AdaBoost offers the benefit of scalability with the linear order of computations, which is critical in massive MIMO-OFDM systems. We then take advantage of the same idea for proposing the data detectors. Numerical results validate the efficiency of the proposed channel estimators and data detectors compared to other methods. They show comparable/better performance to that of the state-of-the-art methods, but require dramatically lower computational complexities and run times.
- Published
- 2024
36. Nutritional Implications of Baby-Led Weaning and Baby Food Pouches as Novel Methods of Infant Feeding: Protocol for an Observational Study
- Author
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Taylor, Rachael W, Conlon, Cathryn A, Beck, Kathryn L, von Hurst, Pamela R, Te Morenga, Lisa A, Daniels, Lisa, Haszard, Jill J, Meldrum, Alison M, McLean, Neve H, Cox, Alice M, Tukuafu, Lesieli, Casale, Maria, Brown, Kimberley J, Jones, Emily A, Katiforis, Ioanna, Rowan, Madeleine, McArthur, Jenny, Fleming, Elizabeth A, Wheeler, Ben J, Houghton, Lisa A, Diana, Aly, and Heath, Anne-Louise M
- Subjects
Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundThe complementary feeding period is a time of unparalleled dietary change for every human, during which the diet changes from one that is 100% milk to one that resembles the usual diet of the wider family in less than a year. Despite this major dietary shift, we know relatively little about food and nutrient intake in infants worldwide and virtually nothing about the impact of baby food “pouches” and “baby-led weaning” (BLW), which are infant feeding approaches that are becoming increasingly popular. Pouches are squeezable containers with a plastic spout that have great appeal for parents, as evidenced by their extraordinary market share worldwide. BLW is an alternative approach to introducing solids that promotes infant self-feeding of whole foods rather than being fed purées, and is popular and widely advocated on social media. The nutritional and health impacts of these novel methods of infant feeding have not yet been determined. ObjectiveThe aim of the First Foods New Zealand study is to determine the iron status, growth, food and nutrient intakes, breast milk intake, eating and feeding behaviors, dental health, oral motor skills, and choking risk of New Zealand infants in general and those who are using pouches or BLW compared with those who are not. MethodsDietary intake (two 24-hour recalls supplemented with food photographs), iron status (hemoglobin, plasma ferritin, and soluble transferrin receptor), weight status (BMI), food pouch use and extent of BLW (questionnaire), breast milk intake (deuterium oxide “dose-to-mother” technique), eating and feeding behaviors (questionnaires and video recording of an evening meal), dental health (photographs of upper and lower teeth for counting of caries and developmental defects of enamel), oral motor skills (questionnaires), and choking risk (questionnaire) will be assessed in 625 infants aged 7.0 to 9.9 months. Propensity score matching will be used to address bias caused by differences in demographics between groups so that the results more closely represent a potential causal effect. ResultsThis observational study has full ethical approval from the Health and Disability Ethics Committees New Zealand (19/STH/151) and was funded in May 2019 by the Health Research Council (HRC) of New Zealand (grant 19/172). Data collection commenced in July 2020, and the first results are expected to be submitted for publication in 2022. ConclusionsThis large study will provide much needed data on the implications for nutritional intake and health with the use of baby food pouches and BLW in infancy. Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12620000459921; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379436. International Registered Report Identifier (IRRID)DERR1-10.2196/29048
- Published
- 2021
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37. Recognition
- Author
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NELSON, VERE HEATH
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- 2024
38. You've got mail: A technology-mediated feedback strategy to support self-regulated learning in first-year university students
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Sauchelli, Isabella, Heath, Georgina, Richardson, Amanda, Lewis, Sally, and Lim, Lisa-Angelique
- Published
- 2024
39. Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study
- Author
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Castro-Espin, Carlota, Cairat, Manon, Navionis, Anne-Sophie, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Mellemkjær, Lene, Mancini, Francesca Romana, Hajji-Louati, Mariem, Severi, Gianluca, Le Cornet, Charlotte, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Sacerdote, Carlotta, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Smith-Byrne, Karl, Heath, Alicia K., Christakoudi, Sofia, Gunter, Marc J., Rinaldi, Sabina, Agudo, Antonio, and Dossus, Laure
- Published
- 2024
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40. Phase II trial of multi-tyrosine kinase inhibitor ESK981 in combination with PD-1 inhibitor nivolumab in patients with metastatic castration-resistant prostate cancer
- Author
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Heath, Elisabeth I., Chen, Wei, Choi, Jae E., Dobson, Kimberlee, Smith, Melanie, Maj, Tomasz, Kryczek, Ilona, Zou, Weiping, Chinnaiyan, Arul M., and Qiao, Yuanyuan
- Published
- 2024
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41. An engineered aldolase enables the biocatalytic synthesis of 2′-functionalized nucleoside analogues
- Author
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Willmott, Matthew, Finnigan, William, Birmingham, William R., Derrington, Sasha R., Heath, Rachel S., Schnepel, Christian, Hayes, Martin A., Smith, Peter D., Falcioni, Francesco, and Turner, Nicholas J.
- Published
- 2024
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42. Social support, happiness, and distress in Brazil during the pandemic (COVID-19)
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Zanon, Cristian, Heath, Patrick J., and Martins, Jucimara Zacarias
- Published
- 2024
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43. Sex differences in trajectories of cortical development in autistic children from 2–13 years of age
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Andrews, Derek S., Diers, Kersten, Lee, Joshua K., Harvey, Danielle J., Heath, Brianna, Cordero, Devani, Rogers, Sally J., Reuter, Martin, Solomon, Marjorie, Amaral, David G., and Nordahl, Christine Wu
- Published
- 2024
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44. Patient and Healthcare Provider Perspectives on Disease Burden of Seborrheic Dermatitis in the United States: Results from a National Survey
- Author
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Polaskey, Meredith T., Aldredge, Lakshi, Heath, Candrice, Acevedo, Moises, Chu, David H., Hanna, Diane, Seal, Melissa S., Zirwas, Matthew, and Chovatiya, Raj
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- 2024
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45. Iontophoresis and electroporation-assisted microneedles: advancements and therapeutic potentials in transdermal drug delivery
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Abbasi, Mehrnaz and Heath, Braeden
- Published
- 2024
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46. Dilemmas of Care (Re) Allocation: Care and Consumption in Pandemic Times
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Heath, Teresa, Gallage, Samanthika, Chatzidakis, Andreas, and Hutton, Martina
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- 2024
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47. Perceived degree of reaching adulthood: a novel predictor of subjective well-being in emerging adulthood
- Author
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Petrovic, Julia, Sadowski, Isabel, Böke, Bilun Naz, Mettler, Jessica, Bastien, Laurianne, and Heath, Nancy L.
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- 2024
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48. SARS-CoV-2 Spike Protein Exacerbates Thromboembolic Cerebrovascular Complications in Humanized ACE2 Mouse Model
- Author
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Heath, Stan P., Hermanns, Veronica C., Coucha, Maha, and Abdelsaid, Mohammed
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- 2024
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49. More than knowing: toward collective, critical, and ecological approaches in educational technology research
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Heath, Marie K., Gleason, Benjamin, Mehta, Rohit, and Hall, Ted
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- 2024
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50. Two new patients with acromesomelic dysplasia, PRKG2 type—identification and characterization of the first missense variant
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Akgun-Dogan, Ozlem, Díaz-González, Francisca, de Lima Jorge, Alexander Augusto, Onenli-Mungan, Neslihan, Menezes Andrade, Nathalia Liberatoscioli, de Polli Cellin, Laurana, Ceylaner, Serdar, Barcellos Rosa Modkovski, Maria, Alanay, Yasemin, and Heath, Karen E.
- Published
- 2024
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