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Abstract We present the explicit form of the Regge trajectory relations for the triply heavy bottom-charm baryons, which can be applied to investigate both the $$\lambda $$ λ -mode excited states and the $$\rho $$ ρ -mode excited states. We estimate the masses of the $$\lambda $$ λ -excited states and the $$\rho $$ ρ -excited states. The results are in agreement with other theoretical predictions. Both the $$\lambda $$ λ -trajectories and the $$\rho $$ ρ -trajectories are discussed. Moreover, the behaviors of the $$\lambda $$ λ - and $$\rho $$ ρ -trajectories for various baryons are discussed. It is shown that both the $$\lambda $$ λ -trajectories and the $$\rho $$ ρ -trajectories for baryons are concave downwards in the $$(M^2,\,x)$$ ( M 2 , x ) plane. The Regge trajectories for the light baryons are approximately linear and become concave as the masses of the light constituents are considered.

Abstract Gastrointestinal stromal tumor (GIST) is the most common mesenchymal original tumor in gastrointestinal (GI) tract and is considered to have varying malignant potential. With the advancement of computer science, radiomics technology and deep learning had been applied in medical researches. It’s vital to construct a more accurate and reliable multimodal predictive model for recurrence-free survival (RFS) aiding for clinical decision-making. A total of 254 patients underwent surgery and pathologically diagnosed with GIST in The First Hospital of China Medical University from 2019 to 2022 were included in the study. Preoperative contrast enhanced computerized tomography (CE-CT) and hematoxylin/eosin (H&E) stained whole slide images (WSI) were acquired for analysis. In the present study, we constructed a sum of 11 models while the multimodal model (average C-index of 0.917 on validation set in 10-fold cross validation) performed the best on external validation cohort with an average C-index of 0.864. The multimodal model also reached statistical significance when validated in the external validation cohort (n = 42) with a p-value of 0.0088 which pertained to the recurrence-free survival (RFS) comparison between the high and low groups using the optimal threshold on the predictive score. We also explored the biological significance of radiomics and pathomics features by visualization and quantitative analysis. In the present study, we constructed a multimodal model predicting RFS of GIST which was prior over unimodal models. We also proposed hypothesis on the correlation between morphology of tumor cell and prognosis.

R. Lyons, R. Pemantle and Y. Peres (Ann. Probab. 24 (4), 1996, 1993–2006) conjectured that for a Cayley graph $ G $ with a growth rate $ \mathrm{gr}(G) > 1 $, the speed of a biased random walk exists and is positive for the biased parameter $ \lambda \in (1, \mathrm{gr}(G)) $. And Gábor Pete (Probability and geometry on groups, Chaper 9, 2024) sheds light on the intricate relationship between the spectral radius of the graph and the speed of the biased random walk. Here, we focus on an example of a Cayley graph, a free product of complete graphs. In this paper, we establish the continuity of the spectral radius of biased random walks with respect to the bias parameter in this class of Cayley graphs. Our method relies on the Kesten-Cheeger-Dodziuk-Mohar theorem and the analysis of generating functions.

Objective To study the effect of squatting toilet behavior on gastric transport time (GTT) and complete examination rate of small bowel (CER) during capsule endoscopy. Methods A total of 122 patients who underwent capsule endoscopy at the Second Affiliated Hospital of Chongqing Medical University from January to December 2019 were recruited and randomly divided into test group (n=63) and control group (n=59). The patients of the test group were asked to take squatting posture for toileting after swallowing the capsule, while those of the control group were asked to take sitting in defecation if needed. GTT, small bowel transit time (SBTT), CER and diagnostic yield (DY) were compared between the 2 groups. Results There were no significant differences in gender, age and conditions during hospitalization between the test group and the control group. The test group obtained obviously higher CER (92.06% vs 79.66%, P=0.048) and shorter GTT (26.7 vs 45.6 min, P=0.027) when compared with the control group. No statistical differences were seen in SBTT and DY between the 2 groups. Conclusion Squatting posture for toileting of patients accepted capsule endoscopy can reduce the transit time of capsules in the stomach and increase the CER.

BackgroundTo determine the relationship between effort-reward imbalance (ERI) and quality of working life (QWL) among medical caregivers and the mediating role of job burnout.MethodsThis was a cross-sectional survey. A total of 787 medical caregivers at seven hospitals from Sichuan and Chongqing, China, between May to September 2023 were included in this observational study. The General Information Questionnaire, Effort-Reward Imbalance Questionnaire (ERI), Maslach Burnout Inventory-General Survey (MBI-GS), and Quality of Working Life Scale (QWL7-32) were used for data collection. SPSS 26.0 and PROCESSv3.3 were used for all data analyses, including descriptive statistics.ResultsA total of 820 questionnaires were distributed, of which only 787 were valid (return rate; 95.98%). The QWL score of medical caregivers was 126.94 ± 16.69. However, QWL scores were significantly different depending on age, number of children, family support status, department, years of experience, night shift status, number of night shifts per month, number of hours worked per day, monthly income, and occurrence of errors or adverse events (p

Abstract Global potent greenhouse gas nitrous oxide (N2O) emissions from soil are accelerating, with increases in the proportion of reactive nitrogen emitted as N2O, i.e., N2O emission factor (EF). Yet, the primary controls and underlying mechanisms of EFs remain unresolved. Based on two independent but complementary global syntheses, and three field studies determining effects of acidity on N2O EFs and soil denitrifying microorganisms, we show that soil pH predominantly controls N2O EFs and emissions by affecting the denitrifier community composition. Analysis of 5438 paired data points of N2O emission fluxes revealed a hump-shaped relationship between soil pH and EFs, with the highest EFs occurring in moderately acidic soils that favored N2O-producing over N2O-consuming microorganisms, and induced high N2O emissions. Our results illustrate that soil pH has a unimodal relationship with soil denitrifiers and EFs, and the net N2O emission depends on both the N2O/(N2O + N2) ratio and overall denitrification rate. These findings can inform strategies to predict and mitigate soil N2O emissions under future nitrogen input scenarios.

Abstract We attempt to present an unified description of the light meson spectra and the light diquark spectra by applying the Regge trajectory approach. However, we find that the direct application of the linear Regge trajectory formula for the light mesons and baryons fails. To address this issue, we fit the experimental data of light meson spectra and the light diquark spectra obtained by other theoretical approaches. By considering the light quark mass and the parameter C in the Cornell potential, we provide a provisional Regge trajectory formula. We also crudely estimate the masses of the light diquarks (ud), (us), and (ss), and find that they agree with other theoretical results. The diquark Regge trajectory not only becomes a new and very simple approach for estimating the spectra of the light diquarks, but also can explicitly show the behavior of the masses with respect to l or $$n_r$$ n r . Moreover, it is expected that the diquark Regge trajectory can provide a simple method for investigating the $$\rho $$ ρ -mode excitations of baryons, tetraquarks and pentaquarks containing diquarks.

N6-methyladenosine (m6A) is the most frequently occurring interior modification in eukaryotic messenger RNA (mRNA), and abnormal mRNA modifications can affect many biological processes. However, m6A’s effect on the metabolism of antiplatelet drugs for the prevention of ischemic stroke (IS) remains largely unclear.

The purpose of this study is to comprehensively evaluate the fruit quality of the new variety "Renong No.1" Phyllanthus emblica L. and determine its optimal harvesting period. 10 indexes such as edible rate and reducing sugar of 21 samples of "Renong No.1" picked in Binchuan county of Yunnan province from 2019 to 2021 were comprehensively evaluated by character analysis, variation analysis, correlation analysis and principal component analysis. The results showed that there were different in fruit quality of "Renong No.1" in different picking periods. The variation coefficients of edible rate, hardness, weight and diameter was 4.22%~17.08%. The variation coefficients of flavonoids, polyphenols, sucrose, reducing sugar, VC and total acid content were 9.45%~26.72%. The fruit firmness, edible rate, reducing sugar and polyphenol content all reached their peaks in the middle and early November in three years. Spearman correlation analysis showed that fruit weight, firmness and edible percentage were positively correlated with reducing sugar content (P

Penicillium species are ubiquitous in the environment and are of substantial importance, especially in industrial and medical aspects. During our investigation of the biodiversity of Penicillium, three new species were discovered in soil samples collected from East and Northeast China. They were determined as new to science based on morphological comparisons and phylogenetic analyses, and were found to belong to the subgenus Penicillium section Robsamsonia and subgenus Aspergilloides sections Aspergilloides and Citrina. Descriptions and illustrations of these species are provided, and their geographic distributions are also discussed.

There has been a controversy as to whether exogenous γ-aminobutyric acid can enter brain regions. The concept of "microbe-gut-brain axis" suggestes that exogenous γ-aminobutyric acid is able to enter the body through oral administration. The γ-aminobutyric acid is subsequently involved in the regulation of gastrointestinal microenvironment, which benefits the central system and provides treatment for neurological diseases. Currently, the γ-aminobutyric acid prepared by microbial method can be used as a new food raw material in certain foods and functional foods rich in γ-aminobutyric acid has been gradually developed. Literature confirms that the intake of a certain amount of γ-aminobutyric could affect nervous system function including improvement of sleep quality, depression-like behavior, behavior and cognitive disorders. This paper is to provide reference for the application of γ-aminobutyric acid in medicine and functional food with the focus on GABA preparation, the relationship between γ-aminobutyric acid and intestinal flora, the effects of exogenous γ-aminobutyric acid on nervous system through intestinal flora and its preparation methods.

In the past three decades, China’s power industry has developed rapidly and solved the problem of efficiency and cleanliness to a certain extent. However, the implementation of the “double carbon” target has put forward the requirements of low carbon development for China’s power industry. Improving energy utilization efficiency, increasing the proportion of zero-carbon energy and carbon-neutral energy, and equipping carbon capture, utilization and storage (CCUS) technology are three important ways to achieve carbon emission reduction in the power industry. Based on the carbon neutral formula of power system, the carbon emission reduction history of China’s power industry and the carbon emission reduction contribution of different pathways between 2000 and 2020 were analyzed, and the current situation and routes of CCUS technology development in China were described. The results show that between 2000 and 2011, improving the efficiency of carbon-containing energy utilization made the main contribution to carbon emission reduction in the power industry, and after 2011, the increase of the proportion of zero-carbon energy contributed more to carbon emission reduction in the power industry. To achieve the goal of carbon neutrality in the power industry, CCUS technology is indispensable when the fossil energy cannot be completely replaced. Currently, the high cost and energy consumption of CCUS technology are the main reasons that hinder its promotion. The fuel source capture technology realizes the graded utilization of energy and the enrichment of carbon components, which reduces the energy consumption of CO2 capture, and the efficiency of fuel source carbon capture system can generally be improved by 5 to 8 percentage points compared with the current mainstream carbon capture technology.

On the basis of retaining the technical identification system of medical negligence, the Medical Association Identification Rules of Medical Damage mainly provides technical services for various types of conciliation work about doctor-patient dispute. Its identification work is still influenced by the thinking of medical negligence technical identification and has certain administrative color. Guidance for Judicial Expertise of Medical Malpractice is mainly reflected that the trial of civil cases and pre-trial mediation of courts need service. Its procedures and evidence review are strictly required by the litigation rules and has the characteristics of public legal services provided as a third-party neutral institution. Technical identification of medical damage, whether organized by the Medical Association or the forensic identification institutions, is carried out under the background of the current Regulations on the Prevention and Treatment of Medical Disputes and the Civil Code of the People’s Republic of China; both have a corresponding positive role in regulating the medical damage identification activities, and have also laid a certain foundation for the establishment of a unified identification system in the future in China. To understand the different characteristics of the medical damage identification rules issued by the Chinese Medical Association and the Ministry of Justice, and to improve the understanding of the standardization of the forensic identification of medical damage, a comparative study was conducted on Medical Association Identification Rules of Medical Damage and Guidance for Judicial Expertise of Medical Malpractice from seven aspects: Concept and legal status, entrust of identification, identification acceptance, identification procedures, identification presentation meeting, theory of medical malpractice evaluation, consequences and causality of medical damage. The subject of evaluation, the function of evidence review, the role of consulting experts, the technical standard system of malpractice evaluation and other contents were emphatically analyzed.

Simultaneously imposed challenges of high-voltage insulation, high dv/dt, high-switching frequency, fast protection, and thermal management associated with the adoption of 10 kV SiC MOSFET, often pose nearly insurmountable barriers to potential users, undoubtedly hindering their penetration in medium-voltage (MV) power conversion. Key novel technologies such as enhanced gate-driver, auxiliary power supply network, PCB planar dc-bus, and high-density inductor are presented, enabling the SiC-based designs in modular MV converters, overcoming aforementioned challenges. However, purely substituting SiC design instead of Si-based ones in modular MV converters, would expectedly yield only limited gains. Therefore, to further elevate SiC-based designs, novel high-bandwidth control strategies such as switching-cycle control (SCC) and integrated capacitor-blocked transistor (ICBT), as well as high-performance/high-bandwidth communication network are developed. All these technologies combined, overcome barriers posed by state-of-the-art Si designs and unlock system level benefits such as very high power density, high-efficiency, fast dynamic response, unrestricted line frequency operation, and improved power quality, all demonstrated throughout this paper.

Abstract Background Sarcopenia predicts poor prognosis of a variety of gastrointestinal malignancies. However, there is a lack of study on the association between skeletal muscle index (SMI) and the prognosis of gastrointestinal stromal tumor (GIST). The aim of this study is to develop a novel nomogram based on sarcopenia for GIST patients to predict overall survival (OS). Methods SMI was measured by computed tomography scan of 107 patients who underwent resection for primary localized gastrointestinal stromal tumor (GIST). Sarcopenia was defined by cutoff values for SMI as 40.1 cm2/m2 and 39.8 cm2/m2 using optimum stratification for males and females respectively. Factors were included in the nomogram were specified by univariate and multiple Cox proportional hazard analysis. Concordance index (C-index) and calibration curves were conducted to measure the discrimination and accuracy of the nomogram. The utility of the nomogram was assessed by the decision curve analysis (DCA). Results Twenty-eight (26.2%) of 107 patients were sarcopenic. Sarcopenia was correlated significantly with body mass index, albumin, female sex, resection style, mitotic index, rupture status, survival. Sarcopenia was significantly related to decreased overall survival (p = 0.003).The nomogram including sarcopenia status, resection style and mitotic index had an excellent discrimination with C-index 0.794. The calibration curves represented a good accordance between the actual observation and nomogram prediction for overall survival. Decision curve analysis illustrated that the nomogram was helpful in clinic. Conclusions We developed a nomogram based on sarcopenia to predict overall survival after resection of GISTs which is an effective and favorable prognostication tool.

Tyrosine kinase inhibitors (TKIs) have greatly improved the prognosis of unresectable and metastatic gastrointestinal stromal tumors (GISTs) in the last two decades. Imatinib and sunitinib are recommended as first-line and second-line therapies, respectively. However, there is a lack of precision therapy for refractory GISTs regarding therapy after imatinib and sunitinib. We comprehensively searched electronic databases, including PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials, from inception to October 2022. Randomized controlled trials featuring comparisons with third-line or over third-line therapies against GISTs were eligible. The primary outcome was progression-free survival (PFS). All network calculations were performed using random effect models, and the ranking of regimens were numerically based on the surface under the cumulative ranking (SUCRA) statistics. A total of seven studies were eligible for inclusion in this network meta-analysis. After analysis, ripretinib was ranked at the top in progression-free survival (PFS), overall survival (OS), and disease control rate (DCR) (SUCRA statistics: 83.1%, 82.5%, and 86.5%, respectively), whereas nilotinib and pimitespib presented better tolerability (SUCRA statistics: 64.9% and 63.8%, respectively). We found that regorafenib seemed more reliable for clinical administration, and ripretinib showed good effectiveness for the over third-line therapy. Precise targeted therapy is a critical direction for the future treatment of GIST, and more high-quality studies of new agents are expected.

The development of blue-phase liquid crystal (BPLC) materials with a wide temperature range is of great significance for practical applications in the optoelectronic field. In the study, bent-core derivatives with a 3-hexyl-2,5-disubstituted thiophene central ring in the λ-shaped molecular structure were designed and synthesized. Their mesomorphic behavior and effect on the blue-phase (BP) temperature range were investigated. Interestingly, a BP was achieved both during the heating and cooling processes by doping with a proper concentration of chiral compound into the thiophene bent-shaped molecule with high rigidity, while derivatives with fluorine atom substitution only exhibited cholesteric phase no matter how many chiral compounds were added. This result proved that BP is highly sensitive to the molecular structures of bent-shaped molecules. Moreover, the BP temperature range was broadened when adding these molecules into a BPLC host, which thus improved the BP temperature range from the initial value, no more than 4 °C, to as much as 24 °C. The experimental phenomena were reasonably explained through molecular simulation calculations. The study may provide some experimental basis and theoretical guidance for the design of novel bent-shaped molecules and BPLC material with a wide temperature range.

To simultaneously achieve space formation flight and target tracking of multiple unmanned aerial vehicles (UAVs) and solve the rotation buffeting problem of the UAV, a robust formation control and target tracking algorithm is proposed. The artificial potential function consisting of formation control term and target tracking term is established, and its convergence is proved. The sliding mode control method with the saturation function is established, and a sufficient condition for sliding mode to occur is analysed. Finally, the numerical simulation is conducted for the proposed algorithm, and the simulation result is analysed. The results show that the proposed algorithm can quickly achieve the formation flight and target tracking of multi-UAVs and improve the tracking performance; meanwhile, it can effectively weaken the rotation buffeting and improve the robustness.

Abstract Background To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal adenocarcinoma based on the new 8th edition of AJCC staging system (8th AJCC stage) that was just applied in clinical practice in 2018. Methods Three hundred fifty-one patients with curatively resected pancreatic adenocarcinoma (PC) from three center hospitals were entered into this multicenter cohort study. Results Increasing tumor size (P

Objective To compare the diagnostic performance of magnifying endoscopy with blue laser imaging (BLI-ME) versus narrowband imaging (NBI-ME) for early upper gastrointestinal cancer. Methods This study was carried out among 466 patients with suspected early upper gastrointestinal cancer (472 lesions) screened by conventional white light endoscopy (WLE). Among these patients, 227 received subsequent examinations by BLI-ME and 239 were examined by NBI-ME. Endoscopic submucosal dissection (ESD) was performed in all the patients with confirmed cancers or highly suspected early cancer under endoscopy. The definite diagnoses were established according to the pathological results following ESD. The consistency between the endoscopic and pathological diagnoses was evaluated using Kappa agreement test, and the detection rate, sensitivity and specificity of the 2 techniques for diagnosis of early upper gastrointestinal cancer were analyzed. Results The pathological results confirmed 269 inflammatory lesions, 127 lesions of atrophy or intestinal metaplasia, 17 lesions of low-grade intraepithelial neoplasia, and 59 lesions of early cancers (with multicentric esophageal cancer). BLI-ME and NBI-ME had consistency rates of 85.2% and 85.1% with the pathological diagnoses, with Kappa values of 0.756 and 0.759, respectively. For early upper gastrointestinal cancer, the detection rates by BLI-ME and NBI-ME was 12.2% and 12.8%, respectively, and their diagnostic sensitivity was 89.3% and 90.3% with a diagnostic specificity of 97.0% and 96.2%, a consistency rate (with the pathological results) of 96.1% and 95.5%, and a Kappa value of 0.810 and 0.825, respectively. Conclusion Both BLI-ME and NBI-ME have high diagnostic value for upper gastrointestinal cancer with comparable diagnostic performances.

DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2. Here the authors present the crystal structure of the D1D2 core from human DDX3X bound to a 23-base pair dsRNA in the pre-unwound state and discuss the implications for helicase mechanism.

In order to make further significant researches on battlefield situation awareness, the paper summarized the challenges in the field at first, which can be listed as the following: the massive and large data makes situation understanding difficult; the rapid change of data makes situation prediction difficult; the complex and heterogeneous data makes situation display difficult. Aiming at the above problems, the paper then discussed the application of artificial intelligence technology, such as knowledge graph, natural language processing and expert system. The appropriate applyment of relevant artificial intelligence technology will greatly improve the capability of battlefield situation awareness.