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7. Synthesis, Crystal Structure, Luminescent Property and Anti-esophageal Tumor Activity of Dinuclear Zinc Complex Based on meso-1,2,3,4-Tetra(1H-benzo[ d]imidazol-2-yl)butane.

Author

Pan, Rong‐Kai, Liu, Sheng‐Gui, Wang, Shao‐Xiang, Li, Guo‐Bi, Su, Wen‐Yi, Huang, Qian‐Wen, and He, Ya‐Mei

Subjects
ZINC compounds synthesis, BENZIMIDAZOLES, METAL complexes, CRYSTAL structure, LUMINESCENCE, ZINC ions, CHLORIDE ions, TREATMENT of esophageal cancer
Abstract

The complex [Zn2(tbb)Cl4] ·4DMF [tbb = meso-1,2,3,4-tetra(1H-benzo-[ d]imidazol-2-yl)butane] was synthesized and characterized by X-ray single crystal structure analyses [C44H54N12Cl4O4Zn2, Mr = 1087.53, crystal system, monoclinic, space group, P21/ n, a = 9.2307(12), b = 11.3748(14), c = 23.874(3) Å, β = 90.480(2)°]. In the complex, one meso-1,2,3,4-tetra(1H-benzo-[ d]imidazol-2-yl)butane coordinates two zinc ions. Both the zinc ions are coordinated in a tetrahedral fashion by two nitrogen atoms of tbb and two chloride ions. The complex emits blue luminescence in DMF solution and exhibits inhibition on the growth of Eca109 cancer cell with IC50 of 22.1 ± 6.7 μM, which was lower than that of cisplatin (62.5 ± 12.4 μM) and ligand (tbb) (24.7 ± 7.8 μM). This complex has potential application in treatment of esophageal cancer. [ABSTRACT FROM AUTHOR]

Published
2015
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