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298 results on '"He, Wenwu"'

6. Long-term survival of esophageal squamous cell carcinoma after surgical treatment in a large-scale retrospective study from a single cancer center

Author

Ni, Kunhan, Li, Zhiyu, Li, Kexun, Li, Changding, Du, Kunyi, Nie, Xin, Liu, Kun, Li, Kunzhi, Huang, Yixuan, Lu, Simiao, Jiang, Longlin, He, Wenwu, Wang, Chenghao, Wang, Kangning, Zhou, Qiang, Li, Haojun, Li, Jialong, Liu, Guangyuan, Xiao, Wenguang, Fang, Qiang, Peng, Lin, Wang, Qifeng, Han, Yongtao, and Leng, Xuefeng

Published
2023
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7. To develop a prognostic model for neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma by analyzing the immune microenvironment

Author

Zhou Yehan, Qin Sheng, Yang Hong, Li Jiayu, Hou Jun, Ji Juan, Shi Min, Yan Jiaxin, Hu Shangzhi, Wang Yi, Wang Qifeng, Leng Xuefeng, He Wenwu, Cheng Xueyan, Liu Yang, and Huang Zongyao

Subjects
esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (NICT), response, tumor immune microenvironment (TIME), predictive model, Immunologic diseases. Allergy, RC581-607
Abstract

ObjectiveThe choice of neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC) is controversial. This study aims to provide a basis for clinical treatment selection by establishing a predictive model for the efficacy of neoadjuvant immunochemotherapy (NICT).MethodsA retrospective analysis of 30 patients was conducted, divided into Response and Non-response groups based on whether they achieved major pathological remission (MPR). Differences in genes and immune microenvironment between the two groups were analyzed through next-generation sequencing (NGS) and multiplex immunofluorescence (mIF). Variables most closely related to therapeutic efficacy were selected through LASSO regression and ROC curves to establish a predictive model. An additional 48 patients were prospectively collected as a validation set to verify the model’s effectiveness.ResultsNGS suggested seven differential genes (ATM, ATR, BIVM-ERCC5, MAP3K1, PRG, RBM10, and TSHR) between the two groups (P < 0.05). mIF indicated significant differences in the quantity and location of CD3+, PD-L1+, CD3+PD-L1+, CD4+PD-1+, CD4+LAG-3+, CD8+LAG-3+, LAG-3+ between the two groups before treatment (P < 0.05). Dynamic mIF analysis also indicated that CD3+, CD8+, and CD20+ all increased after treatment in both groups, with a more significant increase in CD8+ and CD20+ in the Response group (P < 0.05), and a more significant decrease in PD-L1+ (P < 0.05). The three variables most closely related to therapeutic efficacy were selected through LASSO regression and ROC curves: Tumor area PD-L1+ (AUC= 0.881), CD3+PD-L1+ (AUC= 0.833), and CD3+ (AUC= 0.826), and a predictive model was established. The model showed high performance in both the training set (AUC= 0.938) and the validation set (AUC= 0.832). Compared to the traditional CPS scoring criteria, the model showed significant improvements in accuracy (83.3% vs 70.8%), sensitivity (0.625 vs 0.312), and specificity (0.937 vs 0.906).ConclusionNICT treatment may exert anti-tumor effects by enriching immune cells and activating exhausted T cells. Tumor area CD3+, PD-L1+, and CD3+PD-L1+ are closely related to therapeutic efficacy. The model containing these three variables can accurately predict treatment outcomes, providing a reliable basis for the selection of neoadjuvant treatment plans.

Published
2024
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16. Involved-field irradiation versus elective nodal irradiation in patients with locally advanced esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy

Author

Zhou, Xiaoding, primary, Liu, Ying, additional, Zhu, Jie, additional, Li, Jingqiu, additional, Wang, Yi, additional, Huang, Guiyu, additional, Peng, Lin, additional, Han, Yongtao, additional, Leng, Xuefeng, additional, Wang, Chenghao, additional, He, Wenwu, additional, Wu, Lei, additional, and Wang, Qifeng, additional

Published
2024
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18. Peripheral T lymphocyte and immunocyte subset dynamics: markers of neoadjuvant therapy outcomes in esophageal squamous cell carcinoma

Author

Nie, Xin, primary, He, Shuya, additional, Nie, Xinming, additional, Li, Changding, additional, Du, Kunyi, additional, He, Wenwu, additional, Li, Zhiyu, additional, Ni, Kunhan, additional, Lu, Simiao, additional, Wang, Chenghao, additional, Wang, Kangning, additional, Miao, Yan, additional, Jiang, Longlin, additional, Lv, Jiahua, additional, Liu, Guangyuan, additional, Fang, Qiang, additional, Peng, Lin, additional, Xiao, Wenguang, additional, Wang, Qifeng, additional, Wang, Dongsheng, additional, Han, Yongtao, additional, and Leng, Xuefeng, additional

Published
2023
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25. Prognostic Impact of Postoperative Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus: From the Results of NEOCRTEC5010, a Randomized Multicenter Study

Author

Leng, Xuefeng, He, Wenwu, Yang, Hong, Chen, Yuping, Zhu, Chengchu, Fang, Wentao, Yu, Zhentao, Mao, Weimin, Xiang, Jiaqing, Chen, Zhijian, Yang, Haihua, Wang, Jiaming, Pang, Qingsong, Zheng, Xiao, Liu, Hui, Yang, Huanjun, Li, Tao, Zhang, Xu, Li, Qun, Wang, Geng, Mao, Teng, Guo, Xufeng, Lin, Ting, Liu, Mengzhong, Fu, Jianhua, and Han, Yongtao

Published
2021
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28. Long-term Outcomes of Treatment Patterns and Survival for Esophageal Squamous Cell Carcinoma Over than 70 Years: A Multicenter Analysis of 726 Cases

Author

Li, Kexun, primary, Nie, Xin, additional, Li, Changding, additional, He, Wenwu, additional, Lu, Simiao, additional, Liu, Kun, additional, Wang, Chenghao, additional, Du, Kunyi, additional, Li, Jialong, additional, Wang, Kangning, additional, Ni, Kunhan, additional, Jiang, Longlin, additional, Chen, Junqiang, additional, Xiao, Zefen, additional, Han, Yongtao, additional, Peng, Lin, additional, Wang, Qifeng, additional, and Leng, Xuefeng, additional

Published
2023
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29. Prognostic Impact of Postoperative Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus: From the Results of NEOCRTEC5010, a Randomized Multicenter Study

Author

Leng, Xuefeng, He, Wenwu, Yang, Hong, Chen, Yuping, Zhu, Chengchu, Fang, Wentao, Yu, Zhentao, Mao, Weimin, Xiang, Jiaqing, Chen, Zhijian, Yang, Haihua, Wang, Jiaming, Pang, Qingsong, Zheng, Xiao, Liu, Hui, Yang, Huanjun, Li, Tao, Zhang, Xu, Li, Qun, Wang, Geng, Mao, Teng, Guo, Xufeng, Lin, Ting, Liu, Mengzhong, Fu, Jianhua, and Han, Yongtao

Published
2019
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34. Resected lymph nodes and survival of patients with esophageal squamous cell carcinoma: an observational study

Author

Li, Kexun, primary, Leng, Xuefeng, additional, He, Wenwu, additional, Du, Kunyi, additional, Li, Changding, additional, Liu, Kun, additional, Wang, Chenghao, additional, Liu, Guangyuan, additional, Li, Zhiyu, additional, Jiang, Longlin, additional, Li, KunZhi, additional, Zhou, Qiang, additional, Li, Jialong, additional, Luo, Xi, additional, Nie, Xin, additional, Lu, Simiao, additional, Li, Haojun, additional, Fang, Qiang, additional, Xiao, Wenguang, additional, Han, Yongtao, additional, and Peng, Lin, additional

Published
2023
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36. Prognostic Significance of positive lymph node regression grade to Neoadjuvant Chemoradiation for Esophageal Squamous Cell Carcinoma

Author

Zhou, Yehan, primary, Liu, Ying, additional, Guo, Peng, additional, Huang, Zongyao, additional, Zhou, Chengmin, additional, Yang, Hong, additional, Qin, Sheng, additional, Zhu, Jie, additional, Wang, Yi, additional, Leng, Xuefeng, additional, He, Wenwu, additional, Wang, Qifeng, additional, and Liu, Yang, additional

Published
2023
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38. Impact of two‑field or three‑field lymphadenectomy on overall survival in middle and lower thoracic esophageal squamous cell carcinoma: A single‑center retrospective analysis

Author

Li, Kexun, primary, Du, Kunyi, additional, Liu, Kun, additional, Nie, Xin, additional, Li, Changding, additional, He, Wenwu, additional, Li, Kunzhi, additional, Wang, Chenghao, additional, Li, Zhiyu, additional, Zheng, Kai, additional, Mao, Tianqin, additional, Jiang, Longlin, additional, Li, Haojun, additional, Miao, Yan, additional, Xie, Qin, additional, Fang, Qiang, additional, Han, Yongtao, additional, Leng, Xuefeng, additional, and Peng, Lin, additional

Published
2023
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39. Analysis of Travel Hot Spots of Taxi Passengers Based on Community Detection

Author

Bi, Shuoben, Sheng, Yuyu, He, Wenwu, Fan, Jingjin, and Xu, Ruizhuang

Subjects
China
Abstract

It is an important content of smart city research to study the activity track of urban residents, dig out the hot spot areas and spatial interaction patterns of different residents' activities, and clearly understand the travel rules of urban residents' activities. This study used community detection to analyze taxi passengers' travel hot spots based on taxi pick-up and drop-off data, combined with multisource information such as land use, in the main urban area of Nanjing. The study revealed that, for the purpose of travel, the modularity and anisotropy rate of the community where the passengers were picked up and dropped off were positively correlated during the morning and evening peak hours and negatively correlated at other times. Depending on the community structure, pick-up and drop-off points reached significant aggregation within the community, and interactions among the communities were also revealed. Based on the type of land use, as passengers' travel activity increased, travel hot spots formed clusters in urban spaces. After comparative verification, the results of this study were found to be accurate and reliable and can provide a reference for urban planning and traffic management., Author(s): Shuoben Bi (corresponding author) [1]; Yuyu Sheng [1]; Wenwu He [2]; Jingjin Fan [3]; Ruizhuang Xu [1] 1. Introduction With the rapid development of information technology, spatial analysis driven [...]

Published
2021
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40. The efficacy and safety of neoadjuvant immunotherapy in resectable locally advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis

Author

He, Wenwu, primary, Wang, Chenghao, additional, Li, Changding, additional, Nie, Xin, additional, Li, Haojun, additional, Li, Jialong, additional, Zhao, Na, additional, Chen, Haijun, additional, Miao, Xiaojie, additional, Han, Yongtao, additional, Peng, Lin, additional, and Leng, Xuefeng, additional

Published
2023
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41. Predicting Pathological Response in Esophageal Squamous Cell Carcinoma Patients with Longitudinal CT Radiomics and Disentangled Representation Learning: A Multicenter Study

Author

Zhou, Xiaoding, primary, Yue, Hailin, additional, Zheng, Zhunhao, additional, Wu, Lei, additional, Wang, Yi, additional, Zhou, Yehan, additional, Li, Jingqiu, additional, Liu, Ying, additional, Wan, Gang, additional, Huang, Guiyu, additional, Peng, Lin, additional, Han, Yongtao, additional, Leng, Xuefeng, additional, He, Wenwu, additional, Wang, Chenghao, additional, Wang, Jianxin, additional, Zhu, Jie, additional, Zhang, Wencheng, additional, and Wang, Qifeng, additional

Published
2023
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47. 376. THE IMPACT OF OVERALL SURVIVAL ON TWO-FIELD OR THREE-FIELD LYMPHADENECTOMY IN MIDDLE AND LOWER THORACIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Author

Li, Kexun, primary, Leng, Xuefeng, additional, Li, Changding, additional, Liu, Kun, additional, He, Wenwu, additional, Luo, Xi, additional, Wang, Chenghao, additional, Wang, Qifeng, additional, Wang, Kangning, additional, Liu, Guangyuan, additional, Zhou, Qiang, additional, Jiang, Longlin, additional, Li, Haojun, additional, Mao, Tianqin, additional, Du, Kunyi, additional, Fang, Qiang, additional, Xiao, WenGuang, additional, Han, Yongtao, additional, and Peng, Lin, additional

Published
2022
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48. 362. CLINICAL VALUE AND EFFICACY INDEX OF LYMPHADENECTOMY FOR THORACIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Author

Li, Kexun, primary, Leng, Xue Feng, additional, Du, Kunyi, additional, Liu, Kun, additional, He, Wenwu, additional, Wang, Qifeng, additional, Luo, Xi, additional, Wang, Chenghao, additional, Wang, Kangning, additional, Liu, Guangyuan, additional, Wei, Xing, additional, Li, Haojun, additional, Zhou, Qiang, additional, Li, Zhiyu, additional, Zheng, Kai, additional, Li, Changding, additional, Li, KunZhi, additional, Mao, Tianqin, additional, Deng, Xuyang, additional, Luo, Qiyu, additional, Nie, Xin, additional, Fang, Qiang, additional, Xiao, WenGuang, additional, Han, Yongtao, additional, and Peng, Lin, additional

Published
2022
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49. 365. PROGNOSTIC COMPARISON OF LYMPHOVASCULAR INVASION AND LYMPH NODE METASTASIS IN ESOPHAGEAL CANCER PATIENTS

Author

Li, Kexun, primary, Leng, Xue Feng, additional, Nie, Xin, additional, Liu, Kun, additional, He, Wenwu, additional, Wang, Qifeng, additional, Luo, Xi, additional, Wang, Chenghao, additional, Wang, Kangning, additional, Liu, Guangyuan, additional, Wei, Xing, additional, Li, Haojun, additional, Zhou, Qiang, additional, Li, Zhiyu, additional, Jiang, Longlin, additional, Zheng, Kai, additional, Li, Changding, additional, Mao, Tianqin, additional, Fang, Qiang, additional, Xiao, WenGuang, additional, Han, Yongtao, additional, and Peng, Lin, additional

Published
2022
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50. 373. STRATEGIES ON OPTIMAL LYMPHADENECTOMY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A RETROSPECTIVE ANALYSIS OF 1517 CASES IN A SINGLE CANCER CENTER

Author

Li, Kexun, primary, Leng, Xue Feng, additional, Du, Kunyi, additional, Liu, Kun, additional, He, Wenwu, additional, Wang, Qifeng, additional, Luo, Xi, additional, Wang, Chenghao, additional, Wang, Kangning, additional, Liu, Guangyuan, additional, Wei, Xing, additional, Li, Haojun, additional, Zhou, Qiang, additional, Li, Zhiyu, additional, Jiang, Longlin, additional, Zheng, Kai, additional, Li, Changding, additional, Mao, Tianqin, additional, Fang, Qiang, additional, Xiao, WenGuang, additional, Han, Yongtao, additional, and Peng, Lin, additional

Published
2022
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