Search

This article investigates the effect of winding configuration on the electromagnetic vibration of the 48-slot/8-pole modular dual three-phase (DTP) permanent magnet (PM) machine. First, two winding topologies are discussed based on the phase shift principle, and their phase shift angles are 30° and 60°, respectively. Second, the armature magnetomotive force (MMF) of different winding configurations is derived and compared. The modular DTP-PM machine with 30° phase shift produces the extra 2nd, 18th, 22nd, 26th, and 30th armature MMF harmonic components compared with the 60° phase shift one. Afterward, the electromagnetic force density and radial concentrated force of two modular DTP-PM machines are investigated. The result reveals that the modular DTP-PM machine with 30° phase shift induces the non-negligible 2nd-order vibration under the load condition. This is different from the modular DTP-PM machine with a 60° phase shift which mainly induces 0th-order vibration. Furthermore, the multiphysics field finite-element method is used to calculate the static deformation and vibration acceleration of two modular DTP-PM machines. Finally, the prototype of a 48-slot/8-pole modular DTP-PM machine with a 30° phase shift is manufactured. The experiments are conducted to validate the theoretical analysis.

Background: Gastric cancer (GC) is a malignant tumor with seriously poor outcomes. Studies have shown that microRNAs (miRNAs) play an omnifarious regulatory effect in GC. However, the role of miR-3650 in the progression of GC is not well known.Methods: In this study, miR-3650 expression and its clinical significance were determined using clinical specimens. The biological functions of miR-3650 were determined in gastric cancer cell lines through CCK-8, cell scratch, and transwell experiments. Bioinformatics predictions, combined with Western blot experiments, were employed to explore its downstream molecular targets.Results: We observed that miR-3650 was overexpressed in GC specimens and most cell lines, i.e., 77.8% (MKN28, SNU1, AGS, MKN45, N87, BGC823 and SGC7901). The overexpression correlated with advanced T-stage, N-stage, M-stage, and TNM-stage. Furthermore, miR-3650 promoted the proliferation and migration of gastric cancer cells, and its overexpression promoted the PI3K-AKT-mTOR pathway and inhibited the PTEN and hippo pathways. The potassium ion signaling pathway was also involved in the biological process of miR-3650 promoting cancer.Conclusion: Therefore, we concluded that miR-3650/PTEN/PI3K-AKT-mTOR and miR-3650/hippo pathways are vital in the progression of GC and serve as novel targets for GC therapy.