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33 results on '"He, Qincheng"'

1. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023
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2. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Published
2015
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3. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, III, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E., Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao-Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y.Y., Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu-Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K.C., Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Jr, Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., and Lan, Qing

Published
2017
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5. Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)

Author

Hosgood, III, H. Dean, Song, Minsun, Hsiung, Chao Agnes, Yin, Zhihua, Shu, Xiao-Ou, Wang, Zhaoming, Chatterjee, Nilanjan, Zheng, Wei, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Landi, Maria Teresa, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chien, Li-Hsin, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Kim, Christopher, Seow, Wei Jie, Bassig, Bryan A., Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Wong, Maria Pik, Lu, Dara, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Jr, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2015
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7. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, Dean H., III, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E., Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A., Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J., Chung, Charles C., Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I., Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C.H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K. C., Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F., Jr., Zheng, Wei, Lin, Dongxin, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2015
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8. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C., Sampson, Joshua N., Hoskins, Jason W., Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S., Abnet, Christian C., Adjei, Andrew A., Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E., Ambrosone, Christine B., Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Jr, Andrulis, Irene L., Arici, Cecilia, Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Beane Freeman, Laura E., Berg, Christine D., Berndt, Sonja I., Bertazzi, Pier Alberto, Biritwum, Richard B., Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brennan, Paul, Brinton, Louise A., Brotzman, Michelle, Bueno-de-Mesquita, H. Bas, Buring, Julie E., Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E., Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P., Chu, Lisa W., Clavel-Chapelon, Francoise, Colditz, Graham A., Colt, Joanne S., Conti, David, Cook, Michael B., Cortessis, Victoria K., Crawford, E. David, Cussenot, Olivier, Davis, Faith G., De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P., Di Stefano, Anna Luisa, Diver, W. Ryan, Duell, Eric J., Elena, Joanne W., Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D., Flanagan, Adrienne M., Fraumeni, Joseph F., Jr, Freedman, Neal D., Fridley, Brooke L., Fuchs, Charles S., Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, Garcia-Closas, Reina, Gastier-Foster, Julie M., Gaziano, J. Michael, Gerhard, Daniela S., Giffen, Carol A., Giles, Graham G., Gillanders, Elizabeth M., Giovannucci, Edward L., Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gonzalez, Carlos, Gorlick, Richard, Greene, Mark H., Gross, Myron, Grossman, H. Barton, Grubb, Robert, III, Gu, Jian, Guan, Peng, Haiman, Christopher A., Hallmans, Goran, Hankinson, Susan E., Harris, Curtis C., Hartge, Patricia, Hattinger, Claudia, Hayes, Richard B., He, Qincheng, Helman, Lee, Henderson, Brian E., Henriksson, Roger, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hsing, Ann W., Hsiung, Chao Agnes, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Hunter, David J., Inskip, Peter D., Ito, Hidemi, Jacobs, Eric J., Jacobs, Kevin B., Jenab, Mazda, Ji, Bu-Tian, Johansen, Christoffer, Johansson, Mattias, Johnson, Alison, Kaaks, Rudolf, Kamat, Ashish M., Kamineni, Aruna, Karagas, Margaret, Khanna, Chand, Khaw, Kay-Tee, Kim, Christopher, Kim, In-Sam, Kim, Jin Hee, Kim, Yeul Hong, Kim, Young-Chul, Kim, Young Tae, Kang, Chang Hyun, Jung, Yoo Jin, Kitahara, Cari M., Klein, Alison P., Klein, Robert, Kogevinas, Manolis, Koh, Woon-Puay, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kratz, Christian P., Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kurucu, Nilgun, Lan, Qing, Lathrop, Mark, Lau, Ching C., Lecanda, Fernando, Lee, Kyoung-Mu, Lee, Maxwell P., Le Marchand, Loic, Lerner, Seth P., Li, Donghui, Liao, Linda M., Lim, Wei-Yen, Lin, Dongxin, Lin, Jie, Lindstrom, Sara, Linet, Martha S., Lissowska, Jolanta, Liu, Jianjun, Ljungberg, Börje, Lloreta, Josep, Lu, Daru, Ma, Jing, Malats, Nuria, Mannisto, Satu, Marina, Neyssa, Mastrangelo, Giuseppe, Matsuo, Keitaro, McGlynn, Katherine A., McKean-Cowdin, Roberta, McNeill, Lorna H., McWilliams, Robert R., Melin, Beatrice S., Meltzer, Paul S., Mensah, James E., Miao, Xiaoping, Michaud, Dominique S., Mondul, Alison M., Moore, Lee E., Muir, Kenneth, Niwa, Shelley, Olson, Sara H., Orr, Nick, Panico, Salvatore, Park, Jae Yong, Patel, Alpa V., Patino-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Peplonska, Beata, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Pu, Xia, Purdue, Mark P., Qiao, You-Lin, Rajaraman, Preetha, Riboli, Elio, Risch, Harvey A., Rodabough, Rebecca J., Rothman, Nathaniel, Ruder, Avima M., Ryu, Jeong-Seon, Sanson, Marc, Schned, Alan, Schumacher, Fredrick R., Schwartz, Ann G., Schwartz, Kendra L., Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Severi, Gianluca, Shen, Hongbing, Shen, Min, Shete, Sanjay, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesumaga, Luis, Sierri, Sabina, Loon Sihoe, Alan Dart, Silverman, Debra T., Simon, Matthias, Southey, Melissa C., Spector, Logan, Spitz, Margaret, Stampfer, Meir, Stattin, Par, Stern, Mariana C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael Z., Stram, Daniel O., Strom, Sara S., Su, Wu-Chou, Sund, Malin, Sung, Sook Whan, Swerdlow, Anthony, Tan, Wen, Tanaka, Hideo, Tang, Wei, Tang, Ze-Zhang, Tardon, Adonina, Tay, Evelyn, Taylor, Philip R., Tettey, Yao, Thomas, David M., Tirabosco, Roberto, Tjonneland, Anne, Tobias, Geoffrey S., Toro, Jorge R., Travis, Ruth C., Trichopoulos, Dimitrios, Troisi, Rebecca, Truelove, Ann, Tsai, Ying-Huang, Tucker, Margaret A., Tumino, Rosario, Van Den Berg, David, Van Den Eeden, Stephen K., Vermeulen, Roel, Vineis, Paolo, Visvanathan, Kala, Vogel, Ulla, Wang, Chaoyu, Wang, Chengfeng, Wang, Junwen, Wang, Sophia S., Weiderpass, Elisabete, Weinstein, Stephanie J., Wentzensen, Nicolas, Wheeler, William, White, Emily, Wiencke, John K., Wolk, Alicja, Wolpin, Brian M., Wong, Maria Pik, Wrensch, Margaret, Wu, Chen, Wu, Tangchun, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Yang, Hannah P., Yang, Pan-Chyr, Yatabe, Yasushi, Ye, Yuanqing, Yeboah, Edward D., Yin, Zhihua, Ying, Chen, Yu, Chong-Jen, Yu, Kai, Yuan, Jian-Min, Zanetti, Krista A., Zeleniuch-Jacquotte, Anne, Zheng, Wei, Zhou, Baosen, Mirabello, Lisa, Savage, Sharon A., Kraft, Peter, Chanock, Stephen J., Yeager, Meredith, Landi, Maria Terese, Shi, Jianxin, Chatterjee, Nilanjan, and Amundadottir, Laufey T.

Published
2014
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10. Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

Author

Blechter, Batel, primary, Wong, Jason Y.Y., additional, Agnes Hsiung, Chao, additional, Hosgood, H.Dean, additional, Yin, Zhihua, additional, Shu, Xiao-Ou, additional, Zhang, Han, additional, Shi, Jianxin, additional, Song, Lei, additional, Song, Minsun, additional, Zheng, Wei, additional, Wang, Zhaoming, additional, Caporaso, Neil, additional, Burdette, Laurie, additional, Yeager, Meredith, additional, Berndt, Sonja I., additional, Teresa Landi, Maria, additional, Chen, Chien-Jen, additional, Chang, Gee-Chen, additional, Hsiao, Chin-Fu, additional, Tsai, Ying-Huang, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Su, Wu-Chou, additional, Chen, Yuh-Min, additional, Chien, Li-Hsin, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Wang, Chih-Liang, additional, Hung, Jen-Yu, additional, Lin, Chien-Chung, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Chen, Kun-Chieh, additional, Li, Yao-Jen, additional, Yu, Chong-Jen, additional, Chen, Yi-Song, additional, Chen, Ying-Hsiang, additional, Tsai, Fang-Yu, additional, Jie Seow, Wei, additional, Bassig, Bryan A., additional, Hu, Wei, additional, Ji, Bu-Tian, additional, Wu, Wei, additional, Guan, Peng, additional, He, Qincheng, additional, Gao, Yu-Tang, additional, Cai, Qiuyin, additional, Chow, Wong-Ho, additional, Xiang, Yong-Bing, additional, Lin, Dongxin, additional, Wu, Chen, additional, Wu, Yi-Long, additional, Shin, Min-Ho, additional, Hong, Yun-Chul, additional, Matsuo, Keitaro, additional, Chen, Kexin, additional, Pik Wong, Maria, additional, Lu, Daru, additional, Jin, Li, additional, Wang, Jiu-Cun, additional, Seow, Adeline, additional, Wu, Tangchun, additional, Shen, Hongbing, additional, Fraumeni, Joseph F., additional, Yang, Pan-Chyr, additional, Chang, I-Shou, additional, Zhou, Baosen, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, Chatterjee, Nilanjan, additional, and Lan, Qing, additional

Published
2021
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11. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y.Y., primary, Zhang, Han, additional, Hsiung, Chao A., additional, Shiraishi, Kouya, additional, Yu, Kai, additional, Matsuo, Keitaro, additional, Wong, Maria Pik, additional, Hong, Yun-Chul, additional, Wang, Jiucun, additional, Seow, Wei Jie, additional, Wang, Zhaoming, additional, Song, Minsun, additional, Kim, Hee Nam, additional, Chang, I-Shou, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Wu, Chen, additional, Mitsudomi, Tetsuya, additional, Zheng, Wei, additional, Kim, Jin Hee, additional, Seow, Adeline, additional, Caporaso, Neil E., additional, Shin, Min-Ho, additional, Chung, Lap Ping, additional, An, She-Juan, additional, Wang, Ping, additional, Yang, Yang, additional, Zheng, Hong, additional, Yatabe, Yasushi, additional, Zhang, Xu-Chao, additional, Kim, Young Tae, additional, Cai, Qiuyin, additional, Yin, Zhihua, additional, Kim, Young-Chul, additional, Bassig, Bryan A., additional, Chang, Jiang, additional, Ho, James Chung Man, additional, Ji, Bu-Tian, additional, Daigo, Yataro, additional, Ito, Hidemi, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kamatani, Yoichiro, additional, Honda, Takayuki, additional, Hosgood, H. Dean, additional, Sakamoto, Hiromi, additional, Kunitoh, Hideo, additional, Tsuta, Koji, additional, Watanabe, Shun-ichi, additional, Kubo, Michiaki, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Matsumoto, Shingo, additional, Tsuboi, Masahiro, additional, Goto, Koichi, additional, Shi, Jianxin, additional, Song, Lei, additional, Hua, Xing, additional, Takahashi, Atsushi, additional, Goto, Akiteru, additional, Minamiya, Yoshihiro, additional, Shimizu, Kimihiro, additional, Tanaka, Kazumi, additional, Wei, Fusheng, additional, Matsuda, Fumihiko, additional, Su, Jian, additional, Kim, Yeul Hong, additional, Oh, In-Jae, additional, Song, Fengju, additional, Su, Wu-Chou, additional, Chen, Yu-Min, additional, Chang, Gee-Chen, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Chien, Li-Hsin, additional, Xiang, Yong-Bing, additional, Park, Jae Yong, additional, Kweon, Sun-Seog, additional, Chen, Chien-Jen, additional, Lee, Kyoung-Mu, additional, Blechter, Batel, additional, Li, Haixin, additional, Gao, Yu-Tang, additional, Qian, Biyun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Wang, Wen-Chang, additional, Chung, Charles C., additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Hutchinson, Amy, additional, Berndt, Sonja I., additional, Wu, Wei, additional, Pang, Herbert, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Liu, Li, additional, Kang, C.H., additional, Zhu, Meng, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Wang, Chih-Liang, additional, Hsin, Michael, additional, Sit, Ko-Yung, additional, Ho, James, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho Il, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Wang, Yuzhuo, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Li, Yao-Jen, additional, Li, Jihua, additional, Chen, Hongyan, additional, Yu, Chong-Jen, additional, Jin, Li, additional, Chen, Tzu-Yu, additional, Jiang, Shih-Sheng, additional, Liu, Jie, additional, Yamaji, Taiki, additional, Hicks, Belynda, additional, Wyatt, Kathleen, additional, Li, Shengchao A., additional, Dai, Juncheng, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Song, Bao, additional, Wang, Zhehai, additional, Cheng, Sensen, additional, Li, Xuelian, additional, Ren, Yangwu, additional, Cui, Ping, additional, Iwasaki, Motoki, additional, Shimazu, Taichi, additional, Tsugane, Shoichiro, additional, Zhu, Junjie, additional, Yang, Kaiyun, additional, Jiang, Gening, additional, Fei, Ke, additional, Wu, Guoping, additional, Lin, Hsien-Chin, additional, Chen, Hui-Ling, additional, Fang, Yao-Huei, additional, Tsai, Fang-Yu, additional, Hsieh, Wan-Shan, additional, Yu, Jinming, additional, Stevens, Victoria L., additional, Laird-Offringa, Ite A., additional, Marconett, Crystal N., additional, Rieswijk, Linda, additional, Chao, Ann, additional, Yang, Pan-Chyr, additional, Shu, Xiao-Ou, additional, Wu, Tangchun, additional, Wu, Y.L., additional, Lin, Dongxin, additional, Chen, Kexin, additional, Zhou, Baosen, additional, Huang, Yun-Chao, additional, Kohno, Takashi, additional, Shen, Hongbing, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2020
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12. Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma

Author

Su Meng, Xue Xiaoxia, Cui Zeshi, Li Xuelian, Guan Peng, Li Mingchuan, He Qincheng, Zhou Baosen, Yin Zhihua, Ma Rui, Bai Weijun, Xia Shuyue, Jiang Yanduo, Xu Shun, Lv Yi, and Li Xun

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence treatment effect and survival of cancer patients. This study aimed to investigate the relationship between polymorphisms in ERCC2, ERCC1 and XRCC1 genes and survival of non-smoking female patients with lung adenocarcinoma. Methods We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to evaluate SNPs in ERCC2, ERCC1 and XRCC1 genes among 257 patients. Results The overall median survival time (MST) was 13.07 months. Increasing numbers of either ERCC1 118 or XRCC1 399 variant alleles were associated with shorter survival of non-smoking female lung adenocarcinoma patients (Log-rank P < 0.001). The adjusted hazard ratios (HRs) for individuals with CT or TT genotype at ERCC1 Asn118Asn were 1.48 and 2.67 compared with those with CC genotype. For polymorphism of XRCC1 399, the HRs were 1.28 and 2.68 for GA and AA genotype. When variant alleles across both polymorphisms were combined to analysis, the increasing number of variant alleles was associated with decreasing overall survival. Using the stepwise Cox regression analysis, we found that the polymorphisms in ERCC1 and XRCC1, tumor stage and chemotherapy or radiotherapy status independently predicted overall survival of non-smoking female patients with lung adenocarcinoma. Conclusions Genetic polymorphisms in ERCC1 and XRCC1 genes might be prognostic factors in non-smoking female patients with lung adenocarcinoma.

Published
2009
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13. ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females

Author

Li Xuelian, Su Meng, Yin Zhihua, Li Mingchuan, Ma Rui, He Qincheng, and Zhou Baosen

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer. This study aimed to investigate the association between the ERCC2 751, 312 and ERCC1 118 polymorphisms and the risk of lung adenocarcinoma in Chinese non-smoking females. Methods A hospital-based case-control study of 285 patients and 285 matched controls was conducted. Information concerning demographic and risk factors was obtained for each case and control by a trained interviewer. After informed consent was obtained, each person donated 10 ml blood for biomarker testing. Three polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results This study showed that the individuals with the combined ERCC2 751AC/CC genotypes were at an increased risk for lung adenocarcinoma compared with those carrying the AA genotype [adjusted odds ratios (OR) 1.64, 95% confidence interval (CI) 1.06-2.52]. The stratified analysis suggested that increased risk associated with ERCC2 751 variant genotypes (AC/CC) was more pronounced in individuals without exposure to cooking oil fume (OR 1.98, 95%CI 1.18-3.32) and those without exposure to fuel smoke (OR 2.47, 95%CI 1.46-4.18). Haplotype analysis showed that the A-G-T and C-G-C haplotypes were associated with increased risk of lung adenocarcinoma among non-smoking females (ORs were 1.43 and 2.28, 95%CIs were 1.07-1.91 and 1.34-3.89, respectively). Conclusion ERCC2 751 polymorphism may be a genetic risk modifier for lung adenocarcinoma in non-smoking females in China.

Published
2009
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14. Reliability and accuracy of interview data in non-smoking female lung cancer case-control study

Author

Shi Hailong, Guan Peng, Huang Desheng, He Qincheng, and Zhou Baosen

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Valid interview data is critical to the final results of the study. The purpose of this study was to investigate the reliability of epidemiological data obtained in non-smoking female lung cancer case-control study in China. Methods Fifty-six pairs of cases and controls, 10% percent of all the collected subjects were re-interviewed by three interviewers who underwent identical standardized training. A limited number of questions included in the original survey were asked again, the responses from the re-interview were compared with the original interview. Kappa was calculated by negative rates of agreement, positive rates of agreement and total rates of agreement to the accordance degree between the two interviews. Results The Kappa values were all more than 0.5 in all the studied indexes. The Kappa values descended from 0.92 in family history of cancer to 0.56 in oral contraception use. Errors in collecting and classifying data did occur, and were especially common for complicated clinical events, such as a drug exposure occurring many years before. Conclusion We identified four sources of this variability, three in collecting the data, and one in coding. As a result of these findings, strategies are proposed for improving the quality of interview data obtained in epidemiological research. Before finding a good solution, the strategy of data collecting and coding should be simple and easy to inspect.

Published
2008
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15. Association between GWAS-identified lung adenocarcinoma susceptibility loci andEGFRmutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, primary, Matsuo, Keitaro, additional, Hsiung, Chao Agnes, additional, Shiraishi, Kouya, additional, Song, Minsun, additional, Kim, Hee Nam, additional, Wong, Maria Pik, additional, Hong, Yun-Chul, additional, Hosgood, H. Dean, additional, Wang, Zhaoming, additional, Chang, I-Shou, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Tucker, Margaret, additional, Wei, Hu, additional, Mitsudomi, Tetsuya, additional, Zheng, Wei, additional, Kim, Jin Hee, additional, Zhou, Baosen, additional, Caporaso, Neil E., additional, Albanes, Demetrius, additional, Shin, Min-Ho, additional, Chung, Lap Ping, additional, An, She-Juan, additional, Wang, Ping, additional, Zheng, Hong, additional, Yatabe, Yasushi, additional, Zhang, Xu-Chao, additional, Kim, Young Tae, additional, Shu, Xiao-Ou, additional, Kim, Young-Chul, additional, Bassig, Bryan A., additional, Chang, Jiang, additional, Ho, James Chung Man, additional, Ji, Bu-Tian, additional, Kubo, Michiaki, additional, Daigo, Yataro, additional, Ito, Hidemi, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kamatani, Yoichiro, additional, Honda, Takayuki, additional, Sakamoto, Hiromi, additional, Kunitoh, Hideo, additional, Tsuta, Koji, additional, Watanabe, Shun-Ichi, additional, Nokihara, Hiroshi, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Matsumoto, Shingo, additional, Tsuboi, Masahiro, additional, Goto, Koichi, additional, Yin, Zhihua, additional, Shi, Jianxin, additional, Takahashi, Atsushi, additional, Goto, Akiteru, additional, Minamiya, Yoshihiro, additional, Shimizu, Kimihiro, additional, Tanaka, Kazumi, additional, Wu, Tangchun, additional, Wei, Fusheng, additional, Wong, Jason Y.Y., additional, Matsuda, Fumihiko, additional, Su, Jian, additional, Kim, Yeul Hong, additional, Oh, In-Jae, additional, Song, Fengju, additional, Lee, Victor Ho Fun, additional, Su, Wu-Chou, additional, Chen, Yuh-Min, additional, Chang, Gee-Chen, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Yang, Pan-Chyr, additional, Lin, Hsien-Chih, additional, Xiang, Yong-Bing, additional, Seow, Adeline, additional, Park, Jae Yong, additional, Kweon, Sun-Seog, additional, Chen, Chien-Jen, additional, Li, Haixin, additional, Gao, Yu-Tang, additional, Wu, Chen, additional, Qian, Biyun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Wang, Wen-Chang, additional, Chung, Charles C., additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Jacobs, Kevin B., additional, Hutchinson, Amy, additional, Berndt, Sonja I., additional, He, Xingzhou, additional, Wu, Wei, additional, Wang, Junwen, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Wang, Chih-Liang, additional, Sihoe, Alan Dart Loon, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chan, John K.C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Li, Jihua, additional, Chen, Hongyan, additional, Yu, Chong-Jen, additional, Jin, Li, additional, Lo, Yen-Li, additional, Chen, Ying-Hsiang, additional, Fraumeni, Joseph F., additional, Liu, Jie, additional, Yamaji, Taiki, additional, Yang, Yang, additional, Hicks, Belynda, additional, Wyatt, Kathleen, additional, Li, Shengchao A., additional, Dai, Juncheng, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Song, Bao, additional, Wang, Zhehai, additional, Cheng, Sensen, additional, Li, Xuelian, additional, Ren, Yangwu, additional, Cui, Ping, additional, Iwasaki, Motoki, additional, Shimazu, Taichi, additional, Tsugane, Shoichiro, additional, Zhu, Junjie, additional, Jiang, Gening, additional, Fei, Ke, additional, Wu, Guoping, additional, Chien, Li-Hsin, additional, Chen, Hui-Ling, additional, Su, Yu-Chun, additional, Tsai, Fang-Yu, additional, Chen, Yi-Song, additional, Yu, Jinming, additional, Stevens, Victoria L., additional, Laird-Offringa, Ite A., additional, Marconett, Crystal N., additional, Lin, Dongxin, additional, Chen, Kexin, additional, Wu, Yi-Long, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Rothman, Nathaniel, additional, Kohno, Takashi, additional, Chanock, Stephen J., additional, and Lan, Qing, additional

Published
2016
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16. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. and Gaziano, J. Michael Giffen, Carol Giles, Graham G. and Giovannucci, Edward Glimelius, Bengt Goggins, Michael and Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, III, Robert Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. and Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy and Henderson, Brian Henriksson, Roger Hjalgrim, Henrik and Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. and Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. and Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, III, H. Dean and Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy and Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. and Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu and Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin and Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee and Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk and Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis and Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles and Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles and Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin and Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. and Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung and Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic and Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe and Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca and Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra and North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth and Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William and Park, In Kyu Park, Jae Yong Park, Kyong Hwa and Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. and Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer and Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. and Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine and Schned, Alan Schumacher, Fredrick Schwartz, Kendra and Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol and Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy and Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. and Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya and Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. and Southey, Melissa C. Spinelli, John J. Staines, Anthony and Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. and Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei and Tardon, Adonina Thomas, David Thompson, Carrie A. and Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne and Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. and Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo and Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. and Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping and Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping and Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua and Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert and Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. and Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. and Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. and Kraft, Peter Rothman, Nathaniel Silverman, Debra T. and Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

17. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming Zhu, Bin Zhang, Mingfeng Parikh, Hemang and Jia, Jinping Chung, Charles C. Sampson, Joshua N. Hoskins, Jason W. Hutchinson, Amy Burdette, Laurie Ibrahim, Abdisamad and Hautman, Christopher Raj, Preethi S. Abnet, Christian C. and Adjei, Andrew A. Ahlbom, Anders Albanes, Demetrius Allen, Naomi E. Ambrosone, Christine B. Aldrich, Melinda Amiano, Pilar Amos, Christopher Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Arici, Cecilia Arslan, Alan A. and Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. and Bassig, Bryan A. Freeman, Laura E. Beane Berg, Christine D. and Berndt, Sonja I. Bertazzi, Pier Alberto Biritwum, Richard B. and Black, Amanda Blot, William Boeing, Heiner Boffetta, Paolo and Bolton, Kelly Boutron-Ruault, Marie-Christine Bracci, Paige M. Brennan, Paul Brinton, Louise A. Brotzman, Michelle and Bueno-de-Mesquita, H. Bas Buring, Julie E. Butler, Mary Ann and Cai, Qiuyin Cancel-Tassin, Geraldine Canzian, Federico Cao, Guangwen Caporaso, Neil E. Carrato, Alfredo Carreon, Tania and Carta, Angela Chang, Gee-Chen Chang, I-Shou and Chang-Claude, Jenny Che, Xu Chen, Chien-Jen Chen, Chih-Yi and Chen, Chung-Hsing Chen, Constance Chen, Kuan-Yu Chen, Yuh-Min Chokkalingam, Anand P. Chu, Lisa W. Clavel-Chapelon, Francoise Colditz, Graham A. Colt, Joanne S. Conti, David and Cook, Michael B. Cortessis, Victoria K. Crawford, E. David and Cussenot, Olivier Davis, Faith G. De Vivo, Immaculata and Deng, Xiang Ding, Ti Dinney, Colin P. Di Stefano, Anna Luisa and Diver, W. Ryan Duell, Eric J. Elena, Joanne W. Fan, Jin-Hu Feigelson, Heather Spencer Feychting, Maria Figueroa, Jonine D. Flanagan, Adrienne M. Fraumeni, Jr., Joseph F. and Freedman, Neal D. Fridley, Brooke L. Fuchs, Charles S. and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gastier-Foster, Julie M. Gaziano, J. Michael Gerhard, Daniela S. Giffen, Carol A. Giles, Graham G. Gillanders, Elizabeth M. Giovannucci, Edward L. Goggins, Michael Gokgoz, Nalan Goldstein, Alisa M. Gonzalez, Carlos Gorlick, Richard and Greene, Mark H. Gross, Myron Grossman, H. Barton Grubb, III, Robert Gu, Jian Guan, Peng Haiman, Christopher A. and Hallmans, Goran Hankinson, Susan E. Harris, Curtis C. and Hartge, Patricia Hattinger, Claudia Hayes, Richard B. He, Qincheng Helman, Lee Henderson, Brian E. Henriksson, Roger and Hoffman-Bolton, Judith Hohensee, Chancellor Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. Hosgood, H. Dean and Hsiao, Chin-Fu Hsing, Ann W. Hsiung, Chao Agnes Hu, Nan and Hu, Wei Hu, Zhibin Huang, Ming-Shyan Hunter, David J. and Inskip, Peter D. Ito, Hidemi Jacobs, Eric J. Jacobs, Kevin B. Jenab, Mazda Ji, Bu-Tian Johansen, Christoffer and Johansson, Mattias Johnson, Alison Kaaks, Rudolf Kamat, Ashish M. Kamineni, Aruna Karagas, Margaret Khanna, Chand and Khaw, Kay-Tee Kim, Christopher Kim, In-Sam Kim, Jin Hee and Kim, Yeul Hong Kim, Young-Chul Kim, Young Tae Kang, Chang Hyun Jung, Yoo Jin Kitahara, Cari M. Klein, Alison P. and Klein, Robert Kogevinas, Manolis Koh, Woon-Puay Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles Kratz, Christian P. Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. and Kurucu, Nilgun Lan, Qing Lathrop, Mark Lau, Ching C. and Lecanda, Fernando Lee, Kyoung-Mu Lee, Maxwell P. Le Marchand, Loic Lerner, Seth P. Li, Donghui Liao, Linda M. and Lim, Wei-Yen Lin, Dongxin Lin, Jie Lindstrom, Sara and Linet, Martha S. Lissowska, Jolanta Liu, Jianjun Ljungberg, Boerje Lloreta, Josep Lu, Daru Ma, Jing Malats, Nuria and Mannisto, Satu Marina, Neyssa Mastrangelo, Giuseppe and Matsuo, Keitaro McGlynn, Katherine A. McKean-Cowdin, Roberta and McNeill, Lorna H. McWilliams, Robert R. Melin, Beatrice S. and Meltzer, Paul S. Mensah, James E. Miao, Xiaoping Michaud, Dominique S. Mondul, Alison M. Moore, Lee E. Muir, Kenneth and Niwa, Shelley Olson, Sara H. Orr, Nick Panico, Salvatore and Park, Jae Yong Patel, Alpa V. Patino-Garcia, Ana and Pavanello, Sofia Peeters, Petra H. M. Peplonska, Beata and Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer Pu, Xia and Purdue, Mark P. Qiao, You-Lin Rajaraman, Preetha Riboli, Elio Risch, Harvey A. Rodabough, Rebecca J. Rothman, Nathaniel Ruder, Avima M. Ryu, Jeong-Seon Sanson, Marc and Schned, Alan Schumacher, Fredrick R. Schwartz, Ann G. and Schwartz, Kendra L. Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol Serra, Massimo Sesso, Howard D. and Severi, Gianluca Shen, Hongbing Shen, Min Shete, Sanjay and Shiraishi, Kouya Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sierri, Sabina Sihoe, Alan Dart Loon Silverman, Debra T. Simon, Matthias Southey, Melissa C. Spector, Logan and Spitz, Margaret Stampfer, Meir Stattin, Par Stern, Mariana C. Stevens, Victoria L. Stolzenberg-Solomon, Rachael Z. and Stram, Daniel O. Strom, Sara S. Su, Wu-Chou Sund, Malin and Sung, Sook Whan Swerdlow, Anthony Tan, Wen Tanaka, Hideo and Tang, Wei Tang, Ze-Zhang Tardon, Adonina Tay, Evelyn and Taylor, Philip R. Tettey, Yao Thomas, David M. Tirabosco, Roberto Tjonneland, Anne Tobias, Geoffrey S. Toro, Jorge R. and Travis, Ruth C. Trichopoulos, Dimitrios Troisi, Rebecca and Truelove, Ann Tsai, Ying-Huang Tucker, Margaret A. Tumino, Rosario Van Den Berg, David Van Den Eeden, Stephen K. and Vermeulen, Roel Vineis, Paolo Visvanathan, Kala Vogel, Ulla and Wang, Chaoyu Wang, Chengfeng Wang, Junwen Wang, Sophia S. Weiderpass, Elisabete Weinstein, Stephanie J. Wentzensen, Nicolas Wheeler, William White, Emily Wiencke, John K. and Wolk, Alicja Wolpin, Brian M. Wong, Maria Pik Wrensch, Margaret Wu, Chen Wu, Tangchun Wu, Xifeng Wu, Yi-Long and Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Yang, Hannah P. and Yang, Pan-Chyr Yatabe, Yasushi Ye, Yuanqing Yeboah, Edward D. Yin, Zhihua Ying, Chen Yu, Chong-Jen Yu, Kai and Yuan, Jian-Min Zanetti, Krista A. Zeleniuch-Jacquotte, Anne and Zheng, Wei Zhou, Baosen Mirabello, Lisa Savage, Sharon A. Kraft, Peter Chanock, Stephen J. Yeager, Meredith and Landi, Maria Terese Shi, Jianxin Chatterjee, Nilanjan and Amundadottir, Laufey T.

Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and P-Conditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and P-Conditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and P-Conditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10 215 and P-Conditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene(Region 2: rs451360; P = 1.90 x 10(-18) and P-Conditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

19. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Sampson, Joshua N., primary, Wheeler, William A., additional, Yeager, Meredith, additional, Panagiotou, Orestis, additional, Wang, Zhaoming, additional, Berndt, Sonja I., additional, Lan, Qing, additional, Abnet, Christian C., additional, Amundadottir, Laufey T., additional, Figueroa, Jonine D., additional, Landi, Maria Teresa, additional, Mirabello, Lisa, additional, Savage, Sharon A., additional, Taylor, Philip R., additional, Vivo, Immaculata De, additional, McGlynn, Katherine A., additional, Purdue, Mark P., additional, Rajaraman, Preetha, additional, Adami, Hans-Olov, additional, Ahlbom, Anders, additional, Albanes, Demetrius, additional, Amary, Maria Fernanda, additional, An, She-Juan, additional, Andersson, Ulrika, additional, Andriole, Gerald, additional, Andrulis, Irene L., additional, Angelucci, Emanuele, additional, Ansell, Stephen M., additional, Arici, Cecilia, additional, Armstrong, Bruce K., additional, Arslan, Alan A., additional, Austin, Melissa A., additional, Baris, Dalsu, additional, Barkauskas, Donald A., additional, Bassig, Bryan A., additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Benhamou, Simone, additional, Berg, Christine, additional, Van Den Berg, David, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Birmann, Brenda M., additional, Black, Amanda, additional, Boeing, Heiner, additional, Boffetta, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, Bracci, Paige M., additional, Brinton, Louise, additional, Brooks-Wilson, Angela R., additional, Bueno-de-Mesquita, H. Bas, additional, Burdett, Laurie, additional, Buring, Julie, additional, Butler, Mary Ann, additional, Cai, Qiuyin, additional, Cancel-Tassin, Geraldine, additional, Canzian, Federico, additional, Carrato, Alfredo, additional, Carreon, Tania, additional, Carta, Angela, additional, Chan, John K. C., additional, Chang, Ellen T., additional, Chang, Gee-Chen, additional, Chang, I-Shou, additional, Chang, Jiang, additional, Chang-Claude, Jenny, additional, Chen, Chien-Jen, additional, Chen, Chih-Yi, additional, Chen, Chu, additional, Chen, Chung-Hsing, additional, Chen, Constance, additional, Chen, Hongyan, additional, Chen, Kexin, additional, Chen, Kuan-Yu, additional, Chen, Kun-Chieh, additional, Chen, Ying, additional, Chen, Ying-Hsiang, additional, Chen, Yi-Song, additional, Chen, Yuh-Min, additional, Chien, Li-Hsin, additional, Chirlaque, María-Dolores, additional, Choi, Jin Eun, additional, Choi, Yi Young, additional, Chow, Wong-Ho, additional, Chung, Charles C., additional, Clavel, Jacqueline, additional, Clavel-Chapelon, Françoise, additional, Cocco, Pierluigi, additional, Colt, Joanne S., additional, Comperat, Eva, additional, Conde, Lucia, additional, Connors, Joseph M., additional, Conti, David, additional, Cortessis, Victoria K., additional, Cotterchio, Michelle, additional, Cozen, Wendy, additional, Crouch, Simon, additional, Crous-Bou, Marta, additional, Cussenot, Olivier, additional, Davis, Faith G., additional, Ding, Ti, additional, Diver, W. Ryan, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Duell, Eric J., additional, Ennas, Maria Grazia, additional, Erickson, Ralph L., additional, Feychting, Maria, additional, Flanagan, Adrienne M., additional, Foretova, Lenka, additional, Fraumeni, Joseph F., additional, Freedman, Neal D., additional, Beane Freeman, Laura E., additional, Fuchs, Charles, additional, Gago-Dominguez, Manuela, additional, Gallinger, Steven, additional, Gao, Yu-Tang, additional, Gapstur, Susan M., additional, Garcia-Closas, Montserrat, additional, García-Closas, Reina, additional, Gascoyne, Randy D., additional, Gastier-Foster, Julie, additional, Gaudet, Mia M., additional, Gaziano, J. Michael, additional, Giffen, Carol, additional, Giles, Graham G., additional, Giovannucci, Edward, additional, Glimelius, Bengt, additional, Goggins, Michael, additional, Gokgoz, Nalan, additional, Goldstein, Alisa M., additional, Gorlick, Richard, additional, Gross, Myron, additional, Grubb, Robert, additional, Gu, Jian, additional, Guan, Peng, additional, Gunter, Marc, additional, Guo, Huan, additional, Habermann, Thomas M., additional, Haiman, Christopher A., additional, Halai, Dina, additional, Hallmans, Goran, additional, Hassan, Manal, additional, Hattinger, Claudia, additional, He, Qincheng, additional, He, Xingzhou, additional, Helzlsouer, Kathy, additional, Henderson, Brian, additional, Henriksson, Roger, additional, Hjalgrim, Henrik, additional, Hoffman-Bolton, Judith, additional, Hohensee, Chancellor, additional, Holford, Theodore R., additional, Holly, Elizabeth A., additional, Hong, Yun-Chul, additional, Hoover, Robert N., additional, Horn-Ross, Pamela L., additional, Hosain, G. M. Monawar, additional, Hosgood, H. Dean, additional, Hsiao, Chin-Fu, additional, Hu, Nan, additional, Hu, Wei, additional, Hu, Zhibin, additional, Huang, Ming-Shyan, additional, Huerta, Jose-Maria, additional, Hung, Jen-Yu, additional, Hutchinson, Amy, additional, Inskip, Peter D., additional, Jackson, Rebecca D., additional, Jacobs, Eric J., additional, Jenab, Mazda, additional, Jeon, Hyo-Sung, additional, Ji, Bu-Tian, additional, Jin, Guangfu, additional, Jin, Li, additional, Johansen, Christoffer, additional, Johnson, Alison, additional, Jung, Yoo Jin, additional, Kaaks, Rudolph, additional, Kamineni, Aruna, additional, Kane, Eleanor, additional, Kang, Chang Hyun, additional, Karagas, Margaret R., additional, Kelly, Rachel S., additional, Khaw, Kay-Tee, additional, Kim, Christopher, additional, Kim, Hee Nam, additional, Kim, Jin Hee, additional, Kim, Jun Suk, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Kim, Young-Chul, additional, Kitahara, Cari M., additional, Klein, Alison P., additional, Klein, Robert J., additional, Kogevinas, Manolis, additional, Kohno, Takashi, additional, Kolonel, Laurence N., additional, Kooperberg, Charles, additional, Kricker, Anne, additional, Krogh, Vittorio, additional, Kunitoh, Hideo, additional, Kurtz, Robert C., additional, Kweon, Sun-Seog, additional, LaCroix, Andrea, additional, Lawrence, Charles, additional, Lecanda, Fernando, additional, Lee, Victor Ho Fun, additional, Li, Donghui, additional, Li, Haixin, additional, Li, Jihua, additional, Li, Yao-Jen, additional, Li, Yuqing, additional, Liao, Linda M., additional, Liebow, Mark, additional, Lightfoot, Tracy, additional, Lim, Wei-Yen, additional, Lin, Chien-Chung, additional, Lin, Dongxin, additional, Lindstrom, Sara, additional, Linet, Martha S., additional, Link, Brian K., additional, Liu, Chenwei, additional, Liu, Jianjun, additional, Liu, Li, additional, Ljungberg, Börje, additional, Lloreta, Josep, additional, Lollo, Simonetta Di, additional, Lu, Daru, additional, Lund, Eiluv, additional, Malats, Nuria, additional, Mannisto, Satu, additional, Marchand, Loic Le, additional, Marina, Neyssa, additional, Masala, Giovanna, additional, Mastrangelo, Giuseppe, additional, Matsuo, Keitaro, additional, Maynadie, Marc, additional, McKay, James, additional, McKean-Cowdin, Roberta, additional, Melbye, Mads, additional, Melin, Beatrice S., additional, Michaud, Dominique S., additional, Mitsudomi, Tetsuya, additional, Monnereau, Alain, additional, Montalvan, Rebecca, additional, Moore, Lee E., additional, Mortensen, Lotte Maxild, additional, Nieters, Alexandra, additional, North, Kari E., additional, Novak, Anne J., additional, Oberg, Ann L., additional, Offit, Kenneth, additional, Oh, In-Jae, additional, Olson, Sara H., additional, Palli, Domenico, additional, Pao, William, additional, Park, In Kyu, additional, Park, Jae Yong, additional, Park, Kyong Hwa, additional, Patiño-Garcia, Ana, additional, Pavanello, Sofia, additional, Peeters, Petra H. M., additional, Perng, Reury-Perng, additional, Peters, Ulrike, additional, Petersen, Gloria M., additional, Picci, Piero, additional, Pike, Malcolm C., additional, Porru, Stefano, additional, Prescott, Jennifer, additional, Prokunina-Olsson, Ludmila, additional, Qian, Biyun, additional, Qiao, You-Lin, additional, Rais, Marco, additional, Riboli, Elio, additional, Riby, Jacques, additional, Risch, Harvey A., additional, Rizzato, Cosmeri, additional, Rodabough, Rebecca, additional, Roman, Eve, additional, Roupret, Morgan, additional, Ruder, Avima M., additional, Sanjose, Silvia de, additional, Scelo, Ghislaine, additional, Schned, Alan, additional, Schumacher, Fredrick, additional, Schwartz, Kendra, additional, Schwenn, Molly, additional, Scotlandi, Katia, additional, Seow, Adeline, additional, Serra, Consol, additional, Serra, Massimo, additional, Sesso, Howard D., additional, Setiawan, Veronica Wendy, additional, Severi, Gianluca, additional, Severson, Richard K., additional, Shanafelt, Tait D., additional, Shen, Hongbing, additional, Shen, Wei, additional, Shin, Min-Ho, additional, Shiraishi, Kouya, additional, Shu, Xiao-Ou, additional, Siddiq, Afshan, additional, Sierrasesúmaga, Luis, additional, Sihoe, Alan Dart Loon, additional, Skibola, Christine F., additional, Smith, Alex, additional, Smith, Martyn T., additional, Southey, Melissa C., additional, Spinelli, John J., additional, Staines, Anthony, additional, Stampfer, Meir, additional, Stern, Marianna C., additional, Stevens, Victoria L., additional, Stolzenberg-Solomon, Rachael S., additional, Su, Jian, additional, Su, Wu-Chou, additional, Sund, Malin, additional, Sung, Jae Sook, additional, Sung, Sook Whan, additional, Tan, Wen, additional, Tang, Wei, additional, Tardón, Adonina, additional, Thomas, David, additional, Thompson, Carrie A., additional, Tinker, Lesley F., additional, Tirabosco, Roberto, additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulos, Dimitrios, additional, Tsai, Fang-Yu, additional, Tsai, Ying-Huang, additional, Tucker, Margaret, additional, Turner, Jenny, additional, Vajdic, Claire M., additional, Vermeulen, Roel C. H., additional, Villano, Danylo J., additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Visvanathan, Kala, additional, Wactawski-Wende, Jean, additional, Wang, Chaoyu, additional, Wang, Chih-Liang, additional, Wang, Jiu-Cun, additional, Wang, Junwen, additional, Wei, Fusheng, additional, Weiderpass, Elisabete, additional, Weiner, George J., additional, Weinstein, Stephanie, additional, Wentzensen, Nicolas, additional, White, Emily, additional, Witzig, Thomas E., additional, Wolpin, Brian M., additional, Wong, Maria Pik, additional, Wu, Chen, additional, Wu, Guoping, additional, Wu, Junjie, additional, Wu, Tangchun, additional, Wu, Wei, additional, Wu, Xifeng, additional, Wu, Yi-Long, additional, Wunder, Jay S., additional, Xiang, Yong-Bing, additional, Xu, Jun, additional, Xu, Ping, additional, Yang, Pan-Chyr, additional, Yang, Tsung-Ying, additional, Ye, Yuanqing, additional, Yin, Zhihua, additional, Yokota, Jun, additional, Yoon, Ho-Il, additional, Yu, Chong-Jen, additional, Yu, Herbert, additional, Yu, Kai, additional, Yuan, Jian-Min, additional, Zelenetz, Andrew, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xu-Chao, additional, Zhang, Yawei, additional, Zhao, Xueying, additional, Zhao, Zhenhong, additional, Zheng, Hong, additional, Zheng, Tongzhang, additional, Zheng, Wei, additional, Zhou, Baosen, additional, Zhu, Meng, additional, Zucca, Mariagrazia, additional, Boca, Simina M., additional, Cerhan, James R., additional, Ferri, Giovanni M., additional, Hartge, Patricia, additional, Hsiung, Chao Agnes, additional, Magnani, Corrado, additional, Miligi, Lucia, additional, Morton, Lindsay M., additional, Smedby, Karin E., additional, Teras, Lauren R., additional, Vijai, Joseph, additional, Wang, Sophia S., additional, Brennan, Paul, additional, Caporaso, Neil E., additional, Hunter, David J., additional, Kraft, Peter, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Slager, Susan L., additional, Chanock, Stephen J., additional, and Chatterjee, Nilanjan, additional

Published
2015
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21. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., primary, Hsiung, Chao Agnes, additional, Shu, Xiao-Ou, additional, Seow, Wei Jie, additional, Wang, Zhaoming, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wu, Chen, additional, Hosgood, H. Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Wen, Wanqing, additional, Cawthon, Richard, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Caporaso, Neil E., additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A., additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert J., additional, Chung, Charles C., additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I., additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel C.H, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K. C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wong, Maria Pik, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F., additional, Zheng, Wei, additional, Lin, Dongxin, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2014
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22. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Author

Lan, Qing, primary, Hsiung, Chao A, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wang, Zhaoming, additional, Hosgood, H Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Wong, Maria Pik, additional, Zheng, Wei, additional, Caporaso, Neil, additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Yuenger, Jeffrey, additional, Jacobs, Kevin B, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A, additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, Wu, Chen, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert, additional, Chung, Charles C, additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I, additional, He, Xingzhou, additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Shu, Xiao-Ou, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K C, additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F, additional, Lin, Dongxin, additional, Chanock, Stephen J, additional, and Rothman, Nathaniel, additional

Published
2012
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27. Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma

Author

Yin, Zhihua, primary, Zhou, Baosen, additional, He, Qincheng, additional, Li, Mingchuan, additional, Guan, Peng, additional, Li, Xuelian, additional, Cui, Zeshi, additional, Xue, Xiaoxia, additional, Su, Meng, additional, Ma, Rui, additional, Bai, Weijun, additional, Xia, Shuyue, additional, Jiang, Yanduo, additional, Xu, Shun, additional, Lv, Yi, additional, and Li, Xun, additional

Published
2009
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29. [Correlation among expression of CD44, DNA content and apoptosis in female adenocarcinoma of the lung].

Author

Xue X, Zhang Y, Jiang D, He Q, Cui Z, and Zhou B

Abstract

Background: Cluster of differentiation 44 (CD44) is a family of transmembrane glycoproteins. As cell surface hyaluronate receptor, it has been found to be widely expressed in a variety of cells. The aim of this study is to assess the relationship among CD44 expression, DNA content, proliferation index (PI) and apoptosis in female adenocarcinoma of the lung., Methods: The expression of CD44, DNA index (DI), PI and apoptotic rate were studied in 61 cases of female adenocarcinoma of the lung, paracancerous tissues and 45 cases of benign lesions by flow cytometry., Results: The percent of DNA aneuploidy was 75.41% in adenocarcinoma. The expression of CD44, DI and PI in adenocarcinoma were significantly higher than those in paracancerous and benign controls (P < 0.01), however the apoptotic rate was obviously lower in adenocarcinoma than that in paracancerous and benign controls (P < 0.01). There was a positive correlation between CD44 and DI (P < 0.01), and a negative correlation between apoptosis and DI in adenocarcinoma (P < 0.01)., Conclusions: The expression of CD44, DNA content, proliferation and apoptosis may play important regulating roles in oncogenesis, development and metastasis of female adenocarcinoma of the lung.

Published
2007
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30. [Association of genetic polymorphism in the DNA repair gene XPD with risk of lung cancer in nonsmoking females].

Author

Yin Z, Ma R, Cui Z, Li M, He Q, and Zhou B

Abstract

Background: Xeroderma pigmentosum group D (XPD) is one of the important DNA repair genes. XPD polymorphism at Lys751Gln site has been shown to alter XPD protein function, modulate DNA repair capacity and therefore affect cancer risk. The aim of this study is to explore the relationship between XPD polymorphism and susceptibility to lung cancer in nonsmoking female via a population-based case-control study., Methods: There were 105 female patients who were diagnosed with lung cancer between January 2004 and December 2005 from Liaoning Tumor Hospital and 202 Hospital, and the control group included 105 healthy volunteers who were obtained from community centers at the same time. Information concerning demographic and risk factors was obtained for each case and control by a trained interviewer. XPD genotypes of cases and controls were determined by PCR-RFLP method. Two-sided Chi-Square test was used to compare the distribution of the genotypes and risk factors between cases and controls. Unconditional logistic regression analysis was performed to calculate the odds ratios (OR) with 95% confidence intervals (CI) for estimating the association between certain genotypes and lung cancer and exploring the interaction of environmental risk factors and genetic polymorphism., Results: All of the subjects in this study were nonsmoking females in Shenyang. There was no significant demographic difference (age, economic level and education) between cases and controls. There was a significant difference in the frequencies of XPD polymorphism between cancer cases and controls. The frequencies of XPD 751Gln allele were 6.2% in controls and 13.8% in cases (P < 0.05). The risk of lung cancer was higher in those with the Lys/Gln or Gln/Gln genotype than in those with the Lys/Lys genotype and adjusted OR was 2.80 (95% CI: 1.21-6.48). The result showed that cooking fumes exposure was a risk factor for lung cancer (OR was 2.44). Furthermore, an interaction between environmental risk factors and the variant XPD 751Gln allele on the risk of lung cancer was observed. Individuals with both risk gen-otype and exposure to cooking fumes had a higher elevated risk of cancer than those with only one of them (adjusted OR= 6.85 ; 95% CI: 1.69-27.67; P=0.007)., Conclusions: The above findings indicate that the Lys751Gln polymorphism in XPD gene is associated with the risk of lung cancer in nonsmoking females. Individuals with both XPD 751Gln allele genotype and exposure to cooking fumes have a higher elevated risk of cancer than those with only one of them in nonsmoking female population.

Published
2006
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31. [Association of genetic polymorphism in DNA repair gene XRCC1 with risk of lung adenocarcinoma in nonsmoking women].

Author

Li M, Yin Z, Cui Z, He Q, and Zhou B

Abstract

Background: XRCC1 polymorphism at Arg399Gln site has been shown to modulate DNA repair capacity. The aim of this study is to assess the relationship between XRCC1 polymorphism and susceptibility to lung adenocarcinoma in nonsmoking female via a hospital-based case-control study., Methods: Cases were 126 female patients with lung adenocarcinoma from January 2002 to October 2004 in China Medical University Hospital and Liaoning Tumor Hospital. Controls were selected from patients with other pulmonary diseases in the hospitals at the same time. These controls were matched to cases on age (±5 years). Information concerning demographic and risk factors was obtained for each case and control by a trained interviewer. XRCC1 genotypes were determined by PCR-RFLP. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression., Results: Cases showed a higher prevalence of oil smoke compared with controls (P < 0.05). The frequencies of Arg/Arg, Arg/Gln and Gln/Gln in lung adenocarcinoma group (32.54%, 42.86%, 24.60%) were significantly different from those in controls (54.76%, 40.48%, 4.76%) (P < 0.05). The individual carrying Gln/Gln genotype was at a significantly increased risk of lung adenocarcinoma compared with those with Arg/Arg genotype (OR=8.695, 95%CI 3.343-22.614, adjusted for age and oil smoke exposure). Furthermore, the OR of lung adenocarcinoma for the variant XRCC1 399Gln allele combined with exposure to oil smoke was 5.21 (95%CI 1.85-14.70, P < 0.001)., Conclusions: The results indicate that the Arg399Gln polymorphism in XRCC1 is associated with the risk of lung adenocarcinoma in nonsmoking women.

Published
2005
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32. [Study on risk factors of lung cancer in non-smoking women].

Author

Shi H, He Q, Dai X, and Zhou B

Abstract

Background: Lung cancer is a serious health problem in public. Its morbidity and mortality have been increasing rapidly. The mortality of lung cancer in women also increases year by year, in which most of the cases are non-smoking women, and the risk factors still are unclear. The aim of this study is to explore the effects of air pollution in room, passive smoking and other factors on risk of lung cancer., Methods: A total of 618 newly diagnosed female patients with primary lung cancer were enrolled. The controls were selected randomly in the general population in urban districts. Two trained interviewers performed this interview face-to-face using the same questionnaire. The content of questionnaire included the characteristics of demography, history of passive smoking, exposed history of cooking fume, fuel exposure, exposed history of coal fume, history of using 'Kang', pulmonary disease history, cancer history of relatives and occupational history., Results: Passive smoking in childhood was related with lung cancer of non-smoking women (OR= 1.81 , 95%CI=1.46-2.24). The exposure to the cooking fume was of great significance (OR=3.18, 95%CI= 2.55 -3.97). The relationship between coal fume and lung cancer was significant (OR=2.56, 95%CI= 1.83 -4.55). The pulmonary disease history including tuberculosis, chronic bronchitis, asthma, pneumonia, emphysema was strongly associated with lung cancer (OR=1.80, 95%CI=1.43-2.27). The family history of cancer significantly increased the risk of lung cancer (OR=2.09, 95%CI=1.46-3.00), especially the lung cancer history in the first relatives (OR=2.46, 95%CI=1.55-3.90). After adjusting other factors, logistic analysis showed that cooking fume (OR=4.11, 95%CI=2.14-7.89), the pulmonary disease history (OR= 2.05 , 95%CI=1.08-3.93), and the family history of lung cancer (OR=2.89, 95%CI=1.30-6.41) were significant factors., Conclusions: The results show that passive smoking in childhood, cooking oil exposure, coal fume exposure, pulmonary disease history including tuberculosis and family history of lung cancer are risk factors of lung cancer in non-smoking women.

Published
2005
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33. [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma].

Author

Guan P, He Q, and Zhou B

Abstract

Background: To explore the relationship between the expression of COX-2 and pathophysiological features in female pulmonary adenocarcinoma patients., Methods: Expression of COX-2 protein was detected in 50 cases of female pulmonary adenocarcinoma tissues and 50 cases of paracancerous tissues by streptavidin-biotin immunoperoxidase method., Results: The positive rates of COX-2 expression were 78% and 26% in tumor tissues and paracancerous tissues respectively, and there was a highly significant difference between the two groups (Chi-square=27.08, P < 0.01). No significant difference was found among COX-2 expression level, age (P=0.50), smoking history (P=1.0), differentiation grade of tumor cells (P=0.712), TNM stage (P=0.591), size of primary tumor (P=0.63) and lymph nodes metastasis (P=0.88)., Conclusions: Overexpression of COX-2 may play an important role in oncogenesis of female lung adenocarcinoma.

Published
2002
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