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8. High glutamine increases stroke risk by inducing the endothelial‐to‐mesenchymal transition in moyamoya disease

Author

He, Qiheng, primary, Li, Junsheng, additional, Tao, Chuming, additional, Zeng, Chaofan, additional, Liu, Chenglong, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Liu, Wei, additional, Zhang, Bojian, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Wang, Jia, additional, Zhang, Qian, additional, Zhang, Yan, additional, Zhang, Dong, additional, Zhao, Jizong, additional, and Ge, Peicong, additional

Published
2024
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9. Circulating immune cell landscape and T‐cell abnormalities in patients with moyamoya disease

Author

Ge, Peicong, primary, Tao, Chuming, additional, Wang, Wenjing, additional, He, Qiheng, additional, Liu, Chenglong, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Zhang, Bojian, additional, Liu, Xingju, additional, Zhang, Qian, additional, Wang, Rong, additional, Li, Hao, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2024
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11. Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

Author

Ge, Peicong, primary, Yin, Zihan, additional, Tao, Chuming, additional, Zeng, Chaofan, additional, Yu, Xiaofan, additional, Lei, Shixiong, additional, Li, Junsheng, additional, Zhai, Yuanren, additional, Ma, Long, additional, He, Qiheng, additional, Liu, Chenglong, additional, Liu, Wei, additional, Zhang, Bojian, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Zhao, Zhikang, additional, Wang, Shuang, additional, Sun, Wei, additional, Guo, Min, additional, Zheng, Shuai, additional, Zhang, Jia, additional, Deng, Xiaofeng, additional, Liu, Xingju, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhang, Shaosen, additional, Wang, Chengjun, additional, Yang, Ziwen, additional, Zhang, Nijia, additional, Wu, Mingxing, additional, Sun, Jian, additional, Zhou, Yujia, additional, Shi, Zhiyong, additional, Ma, Yonggang, additional, Zhou, Jianpo, additional, Yu, Shaochen, additional, Li, Jiaxi, additional, Lu, Junli, additional, Gao, Faliang, additional, Wang, Wenjing, additional, Chen, Yanming, additional, Zhu, Xingen, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2024
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14. Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.

Author

Cao, Tianqing, He, Shenghong, Wang, Luchen, Chai, Xiaoke, He, Qiheng, Liu, Dongsheng, Wang, Dong, Wang, Nan, He, Jianghong, Wang, Shouyang, Yang, Yi, Zhao, Jizong, and Tan, Huiling

Subjects
DEEP brain stimulation, CONSCIOUSNESS disorders, MOVEMENT disorders, LITERATURE reviews, SUBTHALAMIC nucleus, PATIENT selection, BRAIN injuries
Abstract

Background: The management of patients with disorders of consciousness (DOC) presents substantial challenges in clinical practice. Deep brain stimulation (DBS) has emerged as a potential therapeutic approach, but the lack of standardized regulatory parameters for DBS in DOC hinders definitive conclusions. Objective: This comprehensive review aims to provide a detailed summary of the current issues concerning patient selection, target setting, and modulation parameters in clinical studies investigating the application of DBS for DOC patients. Methods: A meticulous systematic analysis of the literatures was conducted, encompassing articles published from 1968 to April 2023, retrieved from reputable databases (PubMed, Embase, Medline, and Web of Science). Results: The systematic analysis of 21 eligible articles, involving 146 patients with DOC resulting from acquired brain injury or other disorders, revealed significant insights. The most frequently targeted regions were the Centromedian‐parafascicular complex (CM‐pf) nuclei and central thalamus (CT), both recognized for their role in regulating consciousness. However, other targets have also been explored in different studies. The stimulation frequency was predominantly set at 25 or 100 Hz, with pulse width of 120 μs, and voltages ranged from 0 to 4 V. These parameters were customized based on individual patient responses and evaluations. The overall clinical efficacy rate in all included studies was 39.7%, indicating a positive effect of DBS in a subset of DOC patients. Nonetheless, the assessment methods, follow‐up durations, and outcome measures varied across studies, potentially contributing to the variability in reported efficacy rates. Conclusion: Despite the challenges arising from the lack of standardized parameters, DBS shows promising potential as a therapeutic option for patients with DOC. However, there still remains the need for standardized protocols and assessment methods, which are crucial to deepen the understanding and optimizing the therapeutic potential of DBS in this specific patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Genotype‐phenotype correlations in multiple lesions of familial cerebral cavernous malformations concerning phosphatidylinositol 3‐kinase catalytic subunit alpha mutations.

Author

Wang, Jie, Tang, Jihong, Yang, Yingxi, Jiao, Yuming, Huo, Ran, Xu, Hongyuan, Zhao, Shaozhi, Sun, Yingfan, He, Qiheng, Yu, Qifeng, Wang, Shuo, Zhao, Jizong, Wang, Jiguang, and Cao, Yong

Subjects
PHOSPHATIDYLINOSITOL 3-kinases, GENETIC mutation, SOMATIC mutation, HUMAN abnormalities
Abstract

This article provides an overview of a study on familial cerebral cavernous malformations (CCMs), which are abnormal blood vessels in the brain that can lead to bleeding. The study found that there are distinct differences in the natural course and genetic makeup of symptomatic intracerebral hemorrhage (ICH) lesions and dot-sized lesions in familial CCMs. ICH lesions have a higher incidence rate of hemorrhage events and harbor both CCM germline mutations and PIK3CA somatic mutations, while dot-sized lesions only have CCM germline mutations. The article also explores the role of the PI3K-VEGF pathway and the potential of a VEGF inhibitor called bevacizumab as a treatment for CCMs, although further research is needed to evaluate its safety and efficacy. [Extracted from the article]

Published
2024
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19. Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease

Author

Liu, Chenglong, primary, Ge, Peicong, additional, Zeng, Chaofan, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Liu, Wei, additional, He, Qiheng, additional, Li, Junsheng, additional, Liu, Xingju, additional, Wang, Jia, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhao, Jizong, additional, and Zhang, Dong, additional

Published
2023
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22. SomaticGJA4mutation in intracranial extra-axial cavernous hemangiomas

Author

Huo, Ran, primary, Yang, Yingxi, additional, Xu, Hongyuan, additional, Zhao, Shaozhi, additional, Song, Dong, additional, Weng, Jiancong, additional, Ma, Ruochen, additional, Sun, Yingfan, additional, Wang, Jie, additional, Jiao, Yuming, additional, Zhang, Junze, additional, He, Qiheng, additional, Wu, Ruolei, additional, Wang, Shuo, additional, Zhao, Ji-Zong, additional, Zhang, Junting, additional, Wang, Jiguang, additional, and Cao, Yong, additional

Published
2023
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23. Association between methionine sulfoxide and risk of moyamoya disease

Author

Li, Junsheng, primary, Ge, Peicong, additional, He, Qiheng, additional, Liu, Chenglong, additional, Zeng, Chaofan, additional, Tao, Chuming, additional, Zhai, Yuanren, additional, Wang, Jia, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2023
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29. Somatic GJA4 Mutation in Intracranial Extra-axial Cavernous Hemangiomas

Author

Huo, Ran, primary, Yang, Yingxi, additional, Xu, Hongyuan, additional, Zhao, Shaozhi, additional, Song, Dong, additional, Weng, Jiancong, additional, Ma, Ruochen, additional, Sun, Yingfan, additional, Wang, Jie, additional, Jiao, Yuming, additional, Zhang, Junze, additional, He, Qiheng, additional, Wu, Ruolei, additional, Wang, Shuo, additional, Zhao, Jizong, additional, Zhang, Junting, additional, Wang, Jiguang, additional, and Cao, Yong, additional

Published
2022
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32. Association of circulating branched-chain amino acids with risk of moyamoya disease

Author

Zeng, Chaofan, primary, Ge, Peicong, additional, Liu, Chenglong, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Liu, Wei, additional, He, Qiheng, additional, Li, Junsheng, additional, Liu, Xingju, additional, Wang, Jia, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhao, Jizong, additional, and Zhang, Dong, additional

Published
2022
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38. Chinese Cerebrovascular Neurosurgery Society and Chinese Interventional & Hybrid Operation Society, of Chinese Stroke Association Clinical Practice Guidelines for Management of Brain Arteriovenous Malformations in Eloquent Areas

Author

Wang, Mingze, primary, Jiao, Yuming, additional, Zeng, Chaofan, additional, Zhang, Chaoqi, additional, He, Qiheng, additional, Yang, Yi, additional, Tu, Wenjun, additional, Qiu, Hancheng, additional, Shi, Huaizhang, additional, Zhang, Dong, additional, Kang, Dezhi, additional, Wang, Shuo, additional, Liu, A-li, additional, Jiang, Weijian, additional, Cao, Yong, additional, and Zhao, Jizong, additional

Published
2021
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46. Polarization-modulated random fiber laser

Author

Wu, Han, primary, Wang, Zinan, additional, He, Qiheng, additional, Fan, Mengqiu, additional, Li, Yunqi, additional, Sun, Wei, additional, Zhang, Li, additional, Li, Yi, additional, and Rao, Yunjiang, additional

Published
2016
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49. T Cells Immune Imbalance Present in Patients With Multiple Intracranial Aneurysms.

Author

Tao C, Liu C, Ge P, Chan L, Pang Y, Li J, He Q, Liu W, Mou S, Zheng Z, Zhang B, Zhao Z, Sun W, Zhang Q, Wang R, Zhang Y, Wang W, Zhang D, and Zhao J

Abstract

Growing evidence suggests that systemic immune and inflammatory responses may play a critical role in the formation and development of aneurysms. Exploring the differences between single intracranial aneurysm (SIA) and multiple IAs (MIAs) could provide insights for targeted therapies. However, there is a lack of comprehensive and detailed characterization of changes in circulating immune cells in MIAs. Peripheral blood mononuclear cell (PBMC) samples from patients with SIA (n = 16) or MIAs (n = 6) were analyzed using high-dimensional mass cytometry to evaluate the frequency and phenotype of immune cell subtypes. A total of 25 cell clusters were identified, revealing that the immune signature of MIAs included cluster changes. Compared to patients with SIA, patients with MIAs exhibited immune dysfunction and regulatory imbalance in T-cell clusters. They also had reduced numbers of CD8+ T cells and their subgroups CD8+ Te and CD8+ Tem cells, as well as reduced numbers of the CD4+ T-cell subgroup CD27-CD4+ Tem cells. Furthermore, compared to SIA, MIAs were associated with enhanced T-cell immune activation, with elevated expression levels of CD3, CD25, CD27, CCR7, GP130, and interleukin 10. This study provides insights into the circulating immune cell profiles in patients with MIAs, highlighting the similarities and differences between patients with SIA and those with MIAs. Furthermore, the study suggests that circulating immune dysfunction may contribute to development of MIAs., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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50. Anatomical-related factors and outcome of percutaneous short-term spinal cord stimulation electrode shift in patients with disorders of consciousness: a retrospective study.

Author

He Q, Yang C, Xu Y, Niu H, Wu H, Huang H, Chai X, Cao T, Wang N, Wong P, He J, Yang Y, and Zhao J

Abstract

Background: Disorders of consciousness (DoC) represent a spectrum of neurological conditions that pose significant treatment challenges. Percutaneous short-term spinal cord stimulation (SCS) has emerged as a promising experimental diagnostic treatment to assess and potentially improve consciousness levels. However, the effectiveness of this intervention is frequently compromised by the shift of electrodes, particularly in the cervical region, which can negatively affect therapeutic outcomes., Methods: This retrospective study aimed to study if electrodes shift in percutaneous short-term SCS in patients with DoC would affect the outcome. We analyzed the relationship between electrode shift length and patient outcome, as well as the correlation with various anatomical parameters, including the actual length of the cervical spine, linear length, spinal canal transverse diameter, spinal canal diameter, and C2 cone height, in a cohort of patients undergoing the procedure., Results: Our findings revealed that in patients with better outcome, there are significant less patient with electrode shift ( p  = 0.019). Further, a linear correlation was found between the length of electrode shift and patients' outcome (Rho = 0.583, p  = 0.002), with longer shift lengths associated with poorer outcomes. Contrary to our expectations, there was no significant association between the measured anatomical parameters and the extent of electrode shift. However, a trend was found between the actual length of the cervical spine and the shift of the electrode ( p  = 0.098). Notably, the shorter spinal canal transverse diameter was found to be significantly associated with better outcome in patients with DoC receiving percutaneous short-term SCS ( p  = 0.033)., Conclusion: These results highlight the clinical importance of electrode stability in the cervical region during SCS treatment for patients with DoC. Ensuring secure placement of electrodes may play a crucial role in enhancing patients' outcome and minimize postoperative complications. Given the lack of association with expected anatomical parameters, future research should investigate other factors that could impact electrode stability to optimize this therapeutic intervention., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 He, Yang, Xu, Niu, Wu, Huang, Chai, Cao, Wang, Wong, He, Yang and Zhao.)

Published
2024
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