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The higher the enrichment factor, the more significant the enrichment of the differential proteins in the pathway Bioinformatics analysis of the gene expression profile of retinal pigmental epithelial cells based in single-cell RNA sequencing in myopic mice Arch Med Sci 2, February / 2021 577 tration of kynurenic acid transiently increases. Through the single-cell RNA sequencing of the RPE cells, it was found that the cells were exposed to hypoxia during the development of myopia and that hypoxia might lead to functional limitations in the RPE cells [8]. Thus, it can be inferred that RPE cells are exposed to hypoxia during myopia; as RPE cells are oxygen-consuming cells, this hypoxia may activate glycolysis and oxidative phosphorylation in the cells [10-12]. [Extracted from the article]