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Objective: To observe the genotypes and composition ratio of thalassemia in couples of reproductive age, and provide a reference for the prevention and control of thalassemia in Haikou., Methods: Gene diagnosis was performed in 2 494 subjects who were screened for thalassemia before marriage or prenatal by cross-breakpoint PCR, PCR-reverse dot hybridization, and PCR-electrophoresis., Results: A total of 1 037 thalassemia gene carriers were detected in 2 494 samples, with a detection rate of 41.57%, of which 75.02% was α-thalassemia, 18.61% was β-thalassemia, and 6.36% was α-β complex thalassemia. There were 778 cases of α-thalassemia, mainly of deletion type, accounting for 76.99% (599/778). Twenty genotypes were detected, the highest three was -- SEA /αα (33.42%, 260/778), -α 3.7 /αα(23.91%, 186/778), and -α 4.2 /αα(19.02%, 148/778), respectively. A rare HKαα/-α 3.7 was detected, who immigrated from other province. There were 193 cases of β-thalassemia, all of them were light (β 0 /β A or β + /β A ). Eight genotypes were detected, the highest two was 41-42M/N (74.61%, 144/193) and 654M/N (10.36%, 20/193), respectively. There were 66 cases of α-β compound type of thalassemia, 15 genotypes were detected, the highest three was αα WS /αα complex 41-42M/N (28.79%, 19/66), -α 3.7 /αα complex 41-42M/N, and -α 4.2 /αα complex 41-42M/N (16.67%, 11/66 for both)., Conclusion: In Haikou city, the gene carrying rate of thalassemia is very high, and the genotype distribution is different from other cities in Hainan Province, attention should be paid to the impact of population inflow on the frequency spectrum change of local thalassemia gene.

Objective: To classify the nasal tip hypertrophy according to the anatomic characters, so as to select the proper treatment methods., Methods: From Jan. 2010 to Mar. 2012, 92 cases (aged 21-46 years,average 29 years old) with nasal tip hypertrophy were classified as soft tissue hypertrophy, the alar cartilage hypertrophy, separation of alar cartilage, secondary tip hypertrophy after operation, and compound hypertrophy. Treatment methods were selected according to the hypertrophy type, including soft tissue thinning hy medicine or operation, alar cartilage trimming and remodeling, autogenous ear and nasal septal cartilage grafts for elongation or remodeling of nasal tip or columella., Results: The follow-up period was 3 months to one year. The nasal tip hypertrophy was corrected obviously with a natural and harmonious appearance. The results were evaluated hy patients as perfect in 59 cases, good in 26 cases and medium in 7 cases., Conclusion: Satisfactory results can he achieved for the nasal tip hypertrophy with appropriate methods according to the anatomic classification.