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101 results on '"He, J. R."'

1. Search for solar axions by Primakoff effect with the full dataset of the CDEX-1B Experiment

Author

Yang, L. T., Liu, S. K., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, T., Guo, X. Y., He, L., He, J. R., Hu, J. W., Huang, H. X., Huang, T. C., Jiang, L., Karmakar, S., Li, H. B., Li, H. Y., Li, J. M., Li, J., Li, M. C., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, J. X., Liu, Y. D., Liu, Y., Liu, Y. Y., Ma, H., Mao, Y. C., Nie, Q. Y., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Shen, M. B., Singh, M. K., Sun, T. X., Sun, W. L., Tang, C. J., Tian, Y., Wang, G. F., Wang, J. Z., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, Y. C., Xing, H. Y., Xiong, K. Z., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, P., Zhang, Z. H., Zhang, Z. Y., Zhao, J. Z., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We present the first limit on $g_{A\gamma}$ coupling constant using the Bragg-Primakoff conversion based on an exposure of 1107.5 kg days of data from the CDEX-1B experiment at the China Jinping Underground Laboratory. The data are consistent with the null signal hypothesis, and no excess signals are observed. Limits of the coupling $g_{A\gamma}<2.08\times10^{-9}$ GeV$^{-1}$ (95\% C.L.) are derived for axions with mass up to 100 eV/$c^2$. Within the hadronic model of KSVZ, our results exclude axion mass $>5.3~\rm{eV}/c^2$ at 95\% C.L., Comment: 7 pages, 5 figures

Published
2024

2. First Search for Light Fermionic Dark Matter Absorption on Electrons Using Germanium Detector in CDEX-10 Experiment

Author

Liu, J. X., Yang, L. T., Yue, Q., Kang, K. J., Li, Y. J., An, H. P., C., Greeshma, Chang, J. P., Chen, Y. H., Cheng, J. P., Dai, W. H., Deng, Z., Fang, C. H., Geng, X. P., Gong, H., Guo, Q. J., Guo, T., Guo, X. Y., He, L., He, J. R., Hu, J. W., Huang, H. X., Huang, T. C., Jiang, L., Karmakar, S., Li, H. B., Li, H. Y., Li, J. M., Li, J., Li, M. C., Li, Q. Y., Li, R. M. J., Li, X. Q., Li, Y. L., Liang, Y. F., Liao, B., Lin, F. K., Lin, S. T., Liu, S. K., Liu, Y. D., Liu, Y., Liu, Y. Y., Ma, H., Mao, Y. C., Nie, Q. Y., Pan, H., Qi, N. C., Ren, J., Ruan, X. C., Shen, M. B., Singh, M. K., Sun, T. X., Sun, W. L., Tang, C. J., Tian, Y., Wang, G. F., Wang, J. Z., Wang, L., Wang, Q., Wang, Y. F., Wang, Y. X., Wong, H. T., Wu, Y. C., Xing, H. Y., Xiong, K. Z., Xu, R., Xu, Y., Xue, T., Yan, Y. L., Yi, N., Yu, C. X., Yu, H. J., Zeng, M., Zeng, Z., Zhang, B. T., Zhang, F. S., Zhang, L., Zhang, P., Zhang, Z. H., Zhang, Z. Y., Zhao, J. Z., Zhao, K. K., Zhao, M. G., Zhou, J. F., Zhou, Z. Y., and Zhu, J. J.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

We present the first results of the search for sub-MeV fermionic dark matter absorbed by electron targets of Germanium using the 205.4~kg$\cdot$day data collected by the CDEX-10 experiment, with the analysis threshold of 160~eVee. No significant dark matter (DM) signals over the background are observed. Results are presented as limits on the cross section of DM--electron interaction. We present new constraints of cross section in the DM range of 0.1--10 keV/$c^2$ for vector and axial-vector interaction. The upper limit on the cross section is set to be $\rm 5.5\times10^{-46}~cm^2$ for vector interaction, and $\rm 1.8\times10^{-46}~cm^2$ for axial-vector interaction at DM mass of 5 keV/$c^2$., Comment: 6 pages, 4 figures

Published
2024

3. Deep underground laboratory measurement of $^{13}$C($\alpha$,$n$)$^{16}$O in the Gamow windows of the $s$- and $i$-processes

Author

Gao, B., Jiao, T. Y., Li, Y. T., Chen, H., Lin, W. P., An, Z., Ru, L. H., Zhang, Z. C., Tang, X. D., Wang, X. Y., Zhang, N. T., Fang, X., Xie, D. H., Fan, Y. H., Ma, L., Zhang, X., Bai, F., Wang, P., Fan, Y. X., Liu, G., Huang, H. X., Wu, Q., Zhu, Y. B., Chai, J. L., Li, J. Q., Sun, L. T., Wang, S., Cai, J. W., Li, Y. Z., Su, J., Zhang, H., Li, Z. H., Li, Y. J., Li, E. T., Chen, C., Shen, Y. P., Lian, G., Guo, B., Li, X. Y., Zhang, L. Y., He, J. J., Sheng, Y. D., Chen, Y. J., Wang, L. H., Zhang, L., Cao, F. Q., Nan, W., Nan, W. K., Li, G. X., Song, N., Cui, B. Q., Chen, L. H., Ma, R. G., Yan, S. Q., Liao, J. H., Wang, Y. B., Zeng, S., Nan, D., Fan, Q. W., Qi, N. C., Sun, W. L., Guo, X. Y., Zhang, P., Chen, Y. H., Zhou, Y., Zhou, J. F., He, J. R., Shang, C. S., Li, M. C., Kubono, S., Liu, W. P., deBoer, R. J., Wiescher, M., and Pignatari, M.

Subjects
Nuclear Experiment
Abstract

The $^{13}$C($\alpha$,$n$)$^{16}$O reaction is the main neutron source for the slow-neutron-capture (s-) process in Asymptotic Giant Branch stars and for the intermediate (i-) process. Direct measurements at astrophysical energies in above-ground laboratories are hindered by the extremely small cross sections and vast cosmic-ray induced background. We performed the first consistent direct measurement in the range of $E_{\rm c.m.}=$0.24 MeV to 1.9 MeV using the accelerators at the China Jinping Underground Laboratory (CJPL) and Sichuan University. Our measurement covers almost the entire i-process Gamow window in which the large uncertainty of the previous experiments has been reduced from 60\% down to 15\%, eliminates the large systematic uncertainty in the extrapolation arising from the inconsistency of existing data sets, and provides a more reliable reaction rate for the studies of the s- and i-processes along with the first direct determination of the alpha strength for the near-threshold state.

Published
2022
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4. Progress of Underground Nuclear Astrophysics Experiment JUNA in China

Author

Liu, W. P., Li, Z. H., He, J. J., Tang, X. D., Lian, G., Su, J., Shen, Y. P., An, Z., Chao, F. Q., Chang, J. J., Chen, L. H., Chen, H., Chen, X. J., Chen, Y. H., Chen, Z. J., Cui, B. Q., Du, X. C., Fang, X., Fu, C. B., Gan, L., Guo, B., Han, Z. Y., Guo, X. Y., He, G. Z., He, J. R., Heger, A., Hou, S. Q., Huang, H. X., Huang, N., Jia, B. L., Jiang, L. Y., Kubono, S., Li, J. M., Li, M. C., Li, K. A., Li, E. T., Li, T., Li, Y. J., Lugaro, M., Luo, X. B., Ma, H. Y., Ma, S. B., Mei, D. M., Nan, W., Nan, W. K., Qi, N. C., Qian, Y. Z., Qin, J. C., Ren, J., Shang, C. S., Sun, L. T., Sun, W. L., Tan, W. P., Tanihata, I., Wang, S., Wang, P., Wang, Y. B., Wu, Q., Xu, S. W., Yan, S. Q., Yang, L. T., Yang, Y., Yu, X. Q., Yue, Q., Zeng, S., Zhang, L., Zhang, H., Zhang, H. Y., Zhang, L. Y., Zhang, N. T., Zhang, P., Zhang, Q. W., Zhang, T., Zhang, X. P., Zhang, X. Z., Zhao, W., Zhou, J. F., and Zhou, Y.

Published
2022
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7. Evaluation of maternal infections during pregnancy and childhood leukaemia in the offspring

Author

He, J-R, Yu, Y, Fang, F, Gissler, M, Rahimi, K, Hirst, JE, and Dwyer, T

Abstract

Importance: Maternal infection is common during pregnancy and is an important potential cause of fetal genetic and immunological abnormalities. Maternal infection has been reported to be associated with childhood leukemia in previous case-control or small cohort studies. Objective: To evaluate the association of maternal infection during pregnancy with childhood leukemia among offspring in a large study. Design, Setting, and Participants: This population-based cohort study used data from 7 Danish national registries (including the Danish Medical Birth Register, the Danish National Patient Registry, the Danish National Cancer Registry, and others) for all live births in Denmark between 1978 and 2015. Swedish registry data for all live births between 1988 and 2014 were used to validate the findings for the Danish cohort. Data were analyzed from December 2019 to December 2021. Exposures: Maternal infection during pregnancy categorized by anatomic locations identified from the Danish National Patient Registry. Main Outcomes and Measures: The primary outcome was any leukemia; secondary outcomes were acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML). Offspring childhood leukemia was identified in the Danish National Cancer Registry. Associations were first assessed in the whole cohort using Cox proportional hazards regression models, adjusted for potential confounders. A sibling analysis was performed to account for unmeasured familial confounding. Results: This study included 2 222 797 children, 51.3% of whom were boys. During the approximately 27 million person-years of follow-up (mean [SD], 12.0 [4.6] years per person), 1307 children were diagnosed with leukemia (ALL, 1050; AML, 165; or other, 92). Children born to mothers with infection during pregnancy had a 35% increased risk of leukemia (adjusted hazard ratio [HR], 1.35 [95% CI, 1.04-1.77]) compared with offspring of mothers without infection. Maternal genital and urinary tract infections were associated with a 142% and 65% increased risk of childhood leukemia, with HRs of 2.42 (95% CI, 1.50-3.92) and 1.65 (95% CI, 1.15-2.36), respectively. No association was observed for respiratory tract, digestive, or other infections. The sibling analysis showed comparable estimates to the whole-cohort analysis. The association patterns for ALL and AML were similar to that for any leukemia. No association was observed for maternal infection and brain tumors, lymphoma, or other childhood cancers. Conclusions and Relevance: In this cohort study of approximately 2.2 million children, maternal genitourinary tract infection during pregnancy was associated with childhood leukemia among offspring. If confirmed in future studies, our findings may have implications for understanding the etiology and developing preventive measures for childhood leukemia.

Published
2023

9. Direct measurement of the astrophysical F19(p,αγ)O16 reaction in a deep-underground laboratory

Author

Zhang, L. Y., primary, Su, J., additional, He, J. J., additional, deBoer, R. J., additional, Kahl, D., additional, Wiescher, M., additional, Odell, D., additional, Chen, Y. J., additional, Li, X. Y., additional, Wang, J. G., additional, Zhang, L., additional, Cao, F. Q., additional, Zhang, H., additional, Zhang, Z. C., additional, Jiao, T. Y., additional, Sheng, Y. D., additional, Wang, L. H., additional, Song, L. Y., additional, Jiang, X. Z., additional, Li, Z. M., additional, Li, E. T., additional, Wang, S., additional, Lian, G., additional, Li, Z. H., additional, Guo, B., additional, Tang, X. D., additional, Sun, L. T., additional, Wu, Q., additional, Li, J. Q., additional, Cui, B. Q., additional, Chen, L. H., additional, Ma, R. G., additional, Qi, N. C., additional, Sun, W. L., additional, Guo, X. Y., additional, Zhang, P., additional, Chen, Y. H., additional, Zhou, Y., additional, Zhou, J. F., additional, He, J. R., additional, Shang, C. S., additional, Li, M. C., additional, Cheng, J. P., additional, and Liu, W. P., additional

Published
2022
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10. Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Author

Elhakeem, A, Taylor, AE, Inskip, HM, Huang, J, Tafflet, M, Vinther, JL, Asta, F, Erkamp, JS, Gagliardi, L, Guerlich, K, Halliday, J, Harskamp-van Ginkel, MW, He, J-R, Jaddoe, VWV, Lewis, S, Maher, GM, Manios, Y, Mansell, T, McCarthy, FP, McDonald, SW, Medda, E, Nisticò, L, de Moira, AP, Popovic, M, Reiss, IKM, Rodrigues, C, Salika, T, Smith, A, Stazi, MA, Walker, C, Wu, M, Åsvold, BO, Barros, H, Brescianini, S, Burgner, D, Chan, JKY, Charles, M-A, Eriksson, JG, Gaillard, R, Grote, V, Håberg, SE, Heude, B, Koletzko, B, Morton, S, Moschonis, G, Murray, D, O'Mahony, D, Porta, D, Qiu, X, Richiardi, L, Rusconi, F, Saffery, R, Tough, SC, Vrijkotte, TGM, Nelson, SM, Nybo Andersen, A-M, Magnus, MC, Lawlor, DA, and Assisted Reproductive Technology and Future Health (ART-Health) Cohort Collaboration

Subjects
Adult, Male, 42 Health sciences, Adolescent, Reproductive Techniques, Assisted, Infant, 32 Biomedical and clinical sciences, Embryo Transfer, Cohort Studies, Pregnancy, Semen, Child, Preschool, Humans, Female, Obesity, Child, Adiposity
Abstract

IMPORTANCE: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population. OBJECTIVE: To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022. EXPOSURES: Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction). MAIN OUTCOMES AND MEASURES: The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups. RESULTS: Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units). CONCLUSIONS AND RELEVANCE: These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.

Published
2022

13. Direct Measurement of the Astrophysical F19(p,αγ)O16 Reaction in the Deepest Operational Underground Laboratory

Author

Zhang, L. Y., primary, Su, J., additional, He, J. J., additional, Wiescher, M., additional, deBoer, R. J., additional, Kahl, D., additional, Chen, Y. J., additional, Li, X. Y., additional, Wang, J. G., additional, Zhang, L., additional, Cao, F. Q., additional, Zhang, H., additional, Zhang, Z. C., additional, Jiao, T. Y., additional, Sheng, Y. D., additional, Wang, L. H., additional, Song, L. Y., additional, Jiang, X. Z., additional, Li, Z. M., additional, Li, E. T., additional, Wang, S., additional, Lian, G., additional, Li, Z. H., additional, Tang, X. D., additional, Zhao, H. W., additional, Sun, L. T., additional, Wu, Q., additional, Li, J. Q., additional, Cui, B. Q., additional, Chen, L. H., additional, Ma, R. G., additional, Guo, B., additional, Xu, S. W., additional, Li, J. Y., additional, Qi, N. C., additional, Sun, W. L., additional, Guo, X. Y., additional, Zhang, P., additional, Chen, Y. H., additional, Zhou, Y., additional, Zhou, J. F., additional, He, J. R., additional, Shang, C. S., additional, Li, M. C., additional, Zhou, X. H., additional, Zhang, Y. H., additional, Zhang, F. S., additional, Hu, Z. G., additional, Xu, H. S., additional, Chen, J. P., additional, and Liu, W. P., additional

Published
2021
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15. Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis

Author

He, J-R, Ramakrishnan, R, Hirst, JE, Bonaventure, A, Francis, SS, Paltiel, O, Haberg, SE, Lemeshow, S, Olsen, S, Tikellis, G, Magnus, P, Murphy, MFG, Wiemels, JL, Linet, MS, Dwyer, T, He, J-R, Ramakrishnan, R, Hirst, JE, Bonaventure, A, Francis, SS, Paltiel, O, Haberg, SE, Lemeshow, S, Olsen, S, Tikellis, G, Magnus, P, Murphy, MFG, Wiemels, JL, Linet, MS, and Dwyer, T

Abstract

OBJECTIVE: To summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia. STUDY DESIGN: In this systematic review and meta-analysis (PROSPERO number, CRD42018087289), we searched PubMed and Embase to identify relevant studies. We included human studies that reported associations of at least one measure of maternal infection during pregnancy with acute lymphoblastic leukemia (ALL) or all childhood leukemias in the offspring. One reviewer extracted the data first using a standardized form, and the second reviewer independently checked the data for accuracy. Two reviewers used the Newcastle-Ottawa Scale to assess the quality of included studies. We conducted random effects meta-analyses to pool the ORs of specific type of infection on ALL and childhood leukemia. RESULTS: This review included 20 studies (ALL, n = 15; childhood leukemia, n = 14) reported in 32 articles. Most (>65%) included studies reported a positive association between infection variables and ALL or childhood leukemia. Among specific types of infection, we found that influenza during pregnancy was associated with higher risk of ALL (pooled OR, 3.64; 95% CI, 1.34-9.90) and childhood leukemia (pooled OR, 1.77; 95% CI, 1.01-3.11). Varicella (pooled OR, 10.19; 95% CI, 1.98-52.39) and rubella (pooled OR, 2.79; 95% CI, 1.16-6.71) infections were also associated with higher childhood leukemia risk. CONCLUSIONS: Our findings suggest that maternal infection during pregnancy may be associated with a higher risk of childhood leukemia.

Published
2020

19. The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers

Author

Tikellis, G, Dwyer, T, Paltiel, O, Phillips, GS, Lemeshow, S, Golding, J, Northstone, K, Boyd, A, Olsen, S, Ghantous, A, Herceg, Z, Ward, MH, Haberg, SE, Magnus, P, Olsen, J, Strom, M, Mahabir, S, Jones, RR, Ponsonby, A-L, Clavel, J, Charles, MA, Trevathan, E, Qian, ZM, Maule, MM, Qiu, X, Hong, Y-C, Brandelise, S, Roman, E, Wake, M, He, J-R, Linet, MS, Tikellis, G, Dwyer, T, Paltiel, O, Phillips, GS, Lemeshow, S, Golding, J, Northstone, K, Boyd, A, Olsen, S, Ghantous, A, Herceg, Z, Ward, MH, Haberg, SE, Magnus, P, Olsen, J, Strom, M, Mahabir, S, Jones, RR, Ponsonby, A-L, Clavel, J, Charles, MA, Trevathan, E, Qian, ZM, Maule, MM, Qiu, X, Hong, Y-C, Brandelise, S, Roman, E, Wake, M, He, J-R, and Linet, MS

Abstract

BACKGROUND: Childhood cancer is a rare but leading cause of morbidity and mortality. Established risk factors, accounting for <10% of incidence, have been identified primarily from case-control studies. However, recall, selection and other potential biases impact interpretations particularly, for modest associations. A consortium of pregnancy and birth cohorts (I4C) was established to utilise prospective, pre-diagnostic exposure assessments and biological samples. METHODS: Eligibility criteria, follow-up methods and identification of paediatric cancer cases are described for cohorts currently participating or planning future participation. Also described are exposure assessments, harmonisation methods, biological samples potentially available for I4C research, the role of the I4C data and biospecimen coordinating centres and statistical approaches used in the pooled analyses. RESULTS: Currently, six cohorts recruited over six decades (1950s-2000s) contribute data on 388 120 mother-child pairs. Nine new cohorts from seven countries are anticipated to contribute data on 627 500 additional projected mother-child pairs within 5 years. Harmonised data currently includes over 20 "core" variables, with notable variability in mother/child characteristics within and across cohorts, reflecting in part, secular changes in pregnancy and birth characteristics over the decades. CONCLUSIONS: The I4C is the first cohort consortium to have published findings on paediatric cancer using harmonised variables across six pregnancy/birth cohorts. Projected increases in sample size, expanding sources of exposure data (eg, linkages to environmental and administrative databases), incorporation of biological measures to clarify exposures and underlying molecular mechanisms and forthcoming joint efforts to complement case-control studies offer the potential for breakthroughs in paediatric cancer aetiologic research.

Published
2018

25. Validation of Fuel and Emission Calculator model for fuel consumption estimation.

Author

Li, Z. Y., Li, J. H., Yang, J. F., Li, Y., and He, J. R.

Subjects
AUTOMOBILE emissions, AUTOMOTIVE fuel consumption, ELECTRIC vehicles, AIR pollution, PREDICTION models
Abstract

The vehicle emission pollution is a major concern in the society. The electricity vehicle has been widely studied. Traditional electricity vehicle energy and emission control consider to integrate the dynamic route information to optimize the usage of energy. However, the research on transit electricity vehicle energy control is limited. Thus, the research focuses on studying the transit electricity vehicle energy consumption model, Fuel and Emission Calculator(FEC). The paper assesses the accuracy of the model for the buses in specific transit routes under different transit scenarios. The result shows that the average difference between the FEC model and the actual performance is 10.86%. After grade modification, the difference reduces from 10.86% to 7.66%. The trip length also affects the FEC accuracy. A longer trip length indicates a higher model accuracy. The results also reveals that the FEC prediction performance is quite different under different operation mode. [ABSTRACT FROM AUTHOR]

Published
2017
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28. A transportation mode identification method based on mobile phone positioning.

Author

Li, Y., Yang, J. F., Zhang, N. F., Ji, Y., Zhou, H. D., and He, J. R.

Subjects
TRANSPORTATION research, COMMERCIAL products, SHIPMENT of goods, ELECTRONIC data processing, MOBILE geographic information systems, TRANSPORTATION
Abstract

Transportation information is the foundation of traffic planning and management. Given the limitations of traditional data acquisition method in quantity, coverage, and accuracy, the use of mobile phone positioning technology to obtain transportation information and conduct identification has good application prospects. With regard to computation complexity, excessive data processing work, and low accuracy, this study has analysed the temporal and spatial features of three regular transportation modes, namely, bus transportation, driving transportation, and walking transportation (going to and from work on work days). This study has also proposed an identification method for the transportation modes based on the matching of temporal and spatial features. We have recruited volunteers in Guangzhou to conduct transportation data acquisition for two weeks (10 work days) and used this method to perform transportation mode identification. Results show that the accuracy of bus transportation identification is 90.98%, that of driving transportation identification is 90.63%, and that of walking transportation identification is 88.60%. Therefore, the method has high accuracy. This study has demonstrated that the temporal and spatial matching method can accurately identify the three regular transportation modes and provide basic data reference and decision-making support to traffic planning and management departments. Thus, the proposed method can be applied and promoted. [ABSTRACT FROM AUTHOR]

Published
2015
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29. Station transport capacity monitoring method based on travel time electronic fence.

Author

Yang, J. F., Li, Y., Yang, J., Zhang, N. F., He, J. R., and Zhou, H. D.

Subjects
AUTOMOBILE occupants, TRAVEL time (Traffic engineering), BUS occupants, SCHEDULING, TRANSPORTATION research
Abstract

To alleviate the automobile passenger station retention problems, this paper proposed station transport capacity monitoring method based on travel time electronic fence, and compares it with the traditional circular electron fences, roads electronic fences and so on. The test results show that the method can accurately estimate the bus passenger station capacity and transportation capacity curve monitoring weekday can capacity matching and scheduling scheme to provide decision support, in the holiday traffic management can also play the role of capacity scheduling. [ABSTRACT FROM AUTHOR]

Published
2015
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30. A study on the evaluation method of bus routes based on time-space chain for bus trip.

Author

Li, Y., Yang, J. F., Zhang, N. F., Yang, J., Long, W. Y., Zhou, H. D., and He, J. R.

Subjects
BUS travel, SPACETIME, TRAVEL time (Traffic engineering), TRANSPORTATION research, TRAFFIC surveys
Abstract

Accurate evaluation of the bus transit route network is the foundation of scientific planning and management of such a network. The present evaluation methods for the majority of bus transit route networks are characterized by subjectivity, one-sidedness, and inaccuracy. The paper, by introducing Time and Space Geography Theory and GIS-Based Analyzing Method for Spatial Temporal Behavior Data, proposes an evaluation method based on the time-space chain for bus trip and conducts research in terms of time, space, and travel experience. Resident trip investigation and evaluation of bus routes in Guangzhou were made to acquire total travel time, travel time in every station, dwell time, and travel experience of each station. Comparison was made between transportation in morning, common, and evening peak hours and between up route and down route. As a result, an intuitive and visual bus route evaluation was achieved. The research results, which are more specific, detailed, and targeted, conform to the actual requirement of traffic management departments. [ABSTRACT FROM AUTHOR]

Published
2015
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36. Deep Underground Laboratory Measurement of C 13 ( α , n ) O 16 in the Gamow Windows of the s and i Processes

Author

Gao, B., Jiao, T. Y., Li, Y. T., Chen, H., Lin, W. P., An, Z., Ru, L. H., Zhang, Z. C., Tang, X. D., Wang, X. Y., Zhang, N. T., Fang, X., Xie, D. H., Fan, Y. H., Ma, L., Zhang, X., Bai, F., Wang, P., Fan, Y. X., Liu, G., Huang, H. X., Wu, Q., Zhu, Y. B., Chai, J. L., Li, J. Q., Sun, L. T., Wang, S., Cai, J. W., Li, Y. Z., Su, J., Zhang, H., Li, Z. H., Li, Y. J., Li, E. T., Chen, C., Shen, Y. P., Lian, G., Guo, B., Li, X. Y., Zhang, L. Y., He, J. J., Sheng, Y. D., Chen, Y. J., Wang, L. H., Zhang, L., Cao, F. Q., Nan, W., Nan, W. K., Li, G. X., Song, N., Cui, B. Q., Chen, L. H., Ma, R. G., Yan, S. Q., Liao, J. H., Wang, Y. B., Zeng, S., Nan, D., Fan, Q. W., Qi, N. C., Sun, W. L., Guo, X. Y., Zhang, P., Chen, Y. H., Zhou, Y., Zhou, J. F., He, J. R., Shang, C. S., Li, M. C., Kubono, S., Liu, W. P., deBoer, R. J., Wiescher, M., and Pignatari, M.

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41. [Multiple locus variable number tandem repeat analysis genotype polymorphism of Bacillus anthracis in China].

Author

Zhang HJ, Zhang EM, He JR, Li W, and Wei JC

Subjects
China epidemiology, Phylogeny, Anthrax microbiology, Anthrax epidemiology, Multilocus Sequence Typing, Cluster Analysis, Bacillus anthracis genetics, Genotype, Minisatellite Repeats, Polymorphism, Genetic
Abstract

Objective: To analyze the multiple locus variable number tandem repeat analysis (MLVA) genotype polymorphism of Bacillus (B.) anthracis and establish a MLVA genotype database of B. anthracis in China. Methods: B. anthracis strains isolated from different sources in China since 1947 were collected. Genotype identification was carried out using the MLVA15 genotyping protocol based on 15 variable number tandem repeat loci. The genotypes were uniformly numbered and named. The distribution characteristics of the MLVA genotypes of strains were analyzed. Software Bionumerics was used to construct clustering diagrams to analyze the genetic relationships. Results: The MLVA15 clustering analysis subdivided the isolates into 4 major groups and 91 genotypes, 54 of which were unique to China. The genotypes from MLVA15-CHN1 to MLVA15-CHN6 were widely distributed throughout China and in all eras, while other genotypes were restricted to certain regions or eras. Conclusions: This study established a MLVA genotype database of B. anthracis , which provides basis for the understanding of MLVA genetic polymorphisms and the control and molecular source tracing of the anthrax outbreaks in China.

Published
2024
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42. [Analysis of epidemic characteristics of anthrax in China from 2017 to 2019 and molecular typing of Bacillus anthracis ].

Author

Zhang EM, Zhang HJ, He JR, Li W, and Wei JC

Subjects
Adult, China epidemiology, Female, Humans, Male, Middle Aged, Molecular Typing, Polymorphism, Single Nucleotide, Skin Diseases, Bacterial, Young Adult, Anthrax epidemiology, Anthrax prevention & control, Bacillus anthracis genetics
Abstract

Objective: To analyze the epidemiological characteristics of anthrax in China from 2017 to 2019 and molecular typing of Bacillus anthracis isolated from some provinces (autonomous regions). Methods: Surveillance data of anthrax cases reported from 2017 to 2019 in the Infectious Disease Surveillance information System of China Disease Prevention and Control and the Public Health Emergency Reporting and Management Information System were collected, and descriptive epidemiological methods were used to analyze the epidemic characteristics, including the temporal, geographic and demographic distribution of this disease. A total of 47 strains of Bacillus anthracis isolated from 2017 to 2019 were analyzed by canSNP and MLVA15. Results: A total of 951 cases of anthrax were reported from 2017 to 2019, of which 938 were cutaneous anthrax, representing 98.63% of the total number reported. It was mainly distributed in the west and northeast of China, and the three provinces with the highest number of cases were Gansu (215), Sichuan (202) and Qinghai (191). Cases had been reported throughout the year, more cases occurred in the summer and autumn, and August was the month with the most cases,66.35% (211/318), 72.32% (243/336) and 68.01% (202/297) of cases were reported during June to September. The age distribution was mainly between 20 and 59 years old, accounting for more than 80% of all cases. The number of male cases was significantly higher than that of female cases, the ratio of male to female was about 3∶1. The occupations were mainly herdsmen and farmers, accounting for 49.70% to 58.18% and 31.45% to 36.70%, respectively. Public health events occurred every year, and 29 events had been reported from 2017 to 2019. canSNP analysis showed that 37 of the 47 strains belonged to the A.Br.001/002 subgroup and 10 belonged to the A.Br.Ames subgroup. MLVA15 analysis showed that there were 17 genotypes, of which 10 genotypes contained only one strain. Conclusion: Cutaneous anthrax was the predominant clinical type in China from 2017 to 2019.The seasonal, geographic and demographic distribution characteristics were evident.Molecular typing methods such as canSNP and MLVA15 can be used to trace the source of infectious diseases and provide technical support for anthrax prevention and control.

Published
2022
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43. Direct Measurement of the Astrophysical ^{19}F(p,αγ)^{16}O Reaction in the Deepest Operational Underground Laboratory.

Author

Zhang LY, Su J, He JJ, Wiescher M, deBoer RJ, Kahl D, Chen YJ, Li XY, Wang JG, Zhang L, Cao FQ, Zhang H, Zhang ZC, Jiao TY, Sheng YD, Wang LH, Song LY, Jiang XZ, Li ZM, Li ET, Wang S, Lian G, Li ZH, Tang XD, Zhao HW, Sun LT, Wu Q, Li JQ, Cui BQ, Chen LH, Ma RG, Guo B, Xu SW, Li JY, Qi NC, Sun WL, Guo XY, Zhang P, Chen YH, Zhou Y, Zhou JF, He JR, Shang CS, Li MC, Zhou XH, Zhang YH, Zhang FS, Hu ZG, Xu HS, Chen JP, and Liu WP

Abstract

Fluorine is one of the most interesting elements in nuclear astrophysics, where the ^{19}F(p,α)^{16}O reaction is of crucial importance for Galactic ^{19}F abundances and CNO cycle loss in first generation Population III stars. As a day-one campaign at the Jinping Underground Nuclear Astrophysics experimental facility, we report direct measurements of the essential ^{19}F(p,αγ)^{16}O reaction channel. The γ-ray yields were measured over E&#95;{c.m.}=72.4-344  keV, covering the Gamow window; our energy of 72.4 keV is unprecedentedly low, reported here for the first time. The experiment was performed under the extremely low cosmic-ray-induced background environment of the China JinPing Underground Laboratory, one of the deepest underground laboratories in the world. The present low-energy S factors deviate significantly from previous theoretical predictions, and the uncertainties are significantly reduced. The thermonuclear ^{19}F(p,αγ)^{16}O reaction rate has been determined directly at the relevant astrophysical energies.

Published
2021
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44. Fetal growth at different gestational periods and risk of impaired childhood growth, low childhood weight and obesity: a prospective birth cohort study.

Author

He JR, Ramakrishnan R, Wei XL, Lu JH, Lu MS, Xiao WQ, Tu S, Liu X, Zhou FJ, Zhang LF, Xia HM, and Qiu X

Subjects
Adult, Child, Preschool, China epidemiology, Cohort Studies, Female, Gestational Age, Humans, Infant, Newborn, Longitudinal Studies, Male, Pediatric Obesity etiology, Pregnancy, Prospective Studies, Infant, Small for Gestational Age growth & development, Pediatric Obesity epidemiology
Abstract

Objective: To examine the longitudinal associations of fetal growth with adverse child growth outcomes and to assess whether maternal metabolic factors modify the associations., Design: Prospective cohort study., Setting: Born in Guangzhou Cohort Study, China., Population: A total of 4818 mother-child pairs., Methods: Fetal growth was assessed according to estimated fetal weight (EFW) from 22 weeks of gestation until birth and the measurement of the birthweight. Fetal growth Z-scores were computed from random effects in the multilevel linear spline models to represent fetal size in early pregnancy (22 weeks of gestation) and growth in mid-pregnancy (22-27 weeks of gestation), early third trimester (28-36 weeks of gestation) and late third trimester (≥37 weeks of gestation)., Main Outcome Measures: Z-scores for childhood stunting, low weight, overweight or obesity, length/height for age (LAZ/HAZ), weight for age (WAZ) and body mass index for age (BMIZ) at the age of 3 years. Adjusted associations were examined using multiple Poisson or linear regression models., Results: Increased Z-scores of fetal size in early pregnancy and growth in mid-pregnancy and early third trimester were associated with a higher risk of childhood overweight or obesity (risk ratios 1.25-1.45). Fetal growth in each period was negatively associated with stunting and low weight, with the strongest associations observed for fetal size in early pregnancy and growth in mid-pregnancy. The results for continuous outcomes (LAZ/HAZ, WAZ and BMIZ) were similar. The associations of fetal growth with overweight or obesity in childhood were stronger among mothers who were underweight and who were overweight or obese than among mothers of normal weight., Conclusions: Accelerated fetal growth before 37 weeks of gestation is associated with children who are overweight or obese, whereas the critical period for stunting and low weight occurs before 28 weeks of gestation., Tweetable Abstract: Fetal growth during different periods is differentially associated with childhood stunting, underweight and overweight or obesity., (© 2021 John Wiley & Sons Ltd.)

Published
2021
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45. [Clinical utility study of 21-gene assay in 927 Chinese patients with early breast cancer].

Author

Wu JY, Fang Y, Lin L, Zong Y, Chen XS, Huang O, He JR, Zhu L, Chen WG, Li YF, and Shen KW

Subjects
Aged, Asian People, Breast Neoplasms chemistry, Breast Neoplasms pathology, China, Female, Humans, Immunohistochemistry, Logistic Models, Neoplasm Grading, Neoplasm Staging, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Breast Neoplasms genetics, Ki-67 Antigen analysis, Receptors, Estrogen analysis, Receptors, Progesterone analysis
Abstract

Objective: To investigate the distribution patterns of 21-gene assay and its influencing factors in Chinese patients with early breast cancer. Methods: Nine hundred and twenty-seven early breast cancer patients were retrospectively recruited from January 2009 to December 2015 at Ruijin Hospital, Shanghai Jiaotong University School of Medicine. The 21-gene reverse transcriptase-polymerase chain reaction(RT-PCR) assay were conducted in paraffin-embedded tumor tissues to calculate the Recurrence Score(RS). Immunohistochemistry(IHC) assay was used to measure the expression levels of estrogen receptor(ER), progesterone receptor(PR) and Ki-67. Concordances of RT-PCR and IHC results were assessed. Correlations of RS and classical clinicopathological factors were evaluated, and logistic regression were applied to determine independent predictive factors for RS. Results: The median RS of 927 patients was 23(range: 0~90), and the proportions of patients categorized as having a low, intermediate, or high risk were 26.5%, 47.7% and 25.8%, respectively. The distribution of RS varied significantly according to different tumor grade, T stage, PR status, Ki-67 index and molecular subtypes( P <0.05 for all). Grade, PR status and Ki-67 index were independent predictive factors for RS. ER, PR status and Ki-67 index showed significantly correlation between RT-PCR and IHC assays, and the concordance rates for ER and PR status were 98.7% and 87.8%, respectively. Conclusions: RS significantly correlated with tumor grade, T stage, PR status, Ki-67 index and subtypes. Grade, PR status and Ki-67 index can independently predict RS. Remarkable concordances of ER, PR status and Ki-67 index are found between RT-PCR and IHC assays.

Published
2017
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46. [Effect of 21-gene recurrence score on chemotherapy decisions for patients with estrogen receptor-positive, epidermal growth factor receptor 2-negative and lymph node-negative early stage-breast cancer].

Author

Mao Y, Chen XS, Liang Y, Wu JY, Huang O, Zong Y, Fang Q, He JR, Zhu L, Chen WG, Li YF, Lin L, Fei XC, and Shen KW

Subjects
Age Factors, Breast Neoplasms genetics, Breast Neoplasms pathology, Chemotherapy, Adjuvant, China, ErbB Receptors analysis, Female, Humans, Lymph Nodes, Middle Aged, Neoplasm Staging, Breast Neoplasms chemistry, Breast Neoplasms drug therapy, Clinical Decision-Making, Neoplasm Recurrence, Local genetics, Receptor, ErbB-2, Receptors, Estrogen
Abstract

Objective: To investigate the effect of 21-gene recurrence score on adjuvant chemotherapy decisions for patients with estrogen receptor (ER)-positive, epidermal growth factor receptor 2 (HER-2)-negative and lymph node (LN)-negative early stage-breast cancer. Methods: One hundred and forty-eight patients with ER+ , HER-2- and LN- early stage breast cancer were recruited in the Ruijin hospital, Shanghai Jiao Tong University School of Medicine. The 21-gene recurrence score (RS)assay was performed and systemic therapeutic decisions were made before and after knowing the RS results under multidisciplinary discussion. The effects of RS assay and the other influential factors on adjuvant chemotherapy decision were further analyzed. Results: After knowing the RS results, treatment decisions were changed in 26 out of 148 patients(17.6%). Among them, 9 out of 26 patients were not recommended for chemotherapy; 16 of 26 had treatment recommendation changed to chemotherapy, and chemotherapy regimen was changed in the last one patient. Multivariate analysis showed that RS, age and histological grade were independent factors of decision-making for adjuvant chemotherapy. Conclusion: Our results suggest that 21-gene recurrence score significantly influences decision making for adjuvant chemotherapy in patients with ER+ , HER-2- and LN- early stage breast cancer.

Published
2017
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47. [Homology analysis and historical tracing for inter-continental Burkholderia pseudomallei strains of sequence type 562].

Author

Zheng X, Wang LX, Wu H, Chen H, Zhu X, He JR, Xia LX, and Li W

Subjects
Asia, Australia, Genotype, Humans, Minisatellite Repeats, Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Burkholderia pseudomallei genetics, Burkholderia pseudomallei isolation & purification, Genome, Bacterial, Genomics methods
Abstract

Objective: To understand the homology of sequence type 562 (ST562) strains of Burkholderia pseudomallei which circulated in two separate continents (Asia and Australia) at different times. Methods: Spe Ⅰrestriction fragments and 4-locus multiple locus variable number tandem repeat analysis (MLVA-4) profiles were extracted from MSHR5858 (ST562 Australia strain) and 350105 (ST562 historical strain of Hainan) genomes respectively by in silico analysis and then compared with the PFGE and MLVA-4 results of five ST562 clinical isolates from Hainan to test their homology. Synteny and homology between MSHR5858 and 350105 genomes were evaluated with bioinformatics methods. Results: Five ST562 clinical strains from Hainan shared same PFGE pattern (similarity>97 % ) and this pattern coincided to the map of Spe Ⅰrestriction fragments of Australian strain MSHR5858. The amounts of genomic restriction fragments ( Spe Ⅰ) for MSHR5858 and 350105 were 31 and 34 respectively, with 31 of them matched by each other. Five ST562 clinical strains of Hainan were distinct by MLVA-4 profiles, among which HPPH43 (MLVA-4 profile: 10, 8, 10, 8) was close to Australia strain MSHR5858 (10, 8, 8, 6), containing identical repeat numbers at VNTR loci 2341k and 1788k; while HK003 (11, 8, 15, 7) and HK061 (11, 8, 17, 7) similar to Hainan historical strain 350105 (11, 8, 11, 8), with same repeat numbers at loci 2341k and 1788k also. High-degree synteny and consistency on genomic contents were observed between 350105 and MSHR5858, indicating a similar origin for the 2 strains. Conclusion: All inter-continental and historical ST562 strains of B. pseudomallei had similar genomic characteristics, supporting the assumption that they had a common origin. Also, it is possible that Hainan historical strain 350105 is the ancestor of all circulating ST562 strains.

Published
2017
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48. [Surgical treatment and prognosis of ductal carcinoma in situ: 526 cases analysis].

Author

Zhu SJ, Chen XS, Wu JY, Huang O, He JR, Zhu L, Chen WG, Li YF, Fei XC, and Shen KW

Subjects
Adult, Aged, Axilla, China, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymph Node Excision, Lymph Nodes, Mastectomy, Mastectomy, Segmental, Middle Aged, Prognosis, Retrospective Studies, Sentinel Lymph Node Biopsy, Survival Rate, Breast Neoplasms therapy, Carcinoma, Ductal, Breast therapy, Carcinoma, Intraductal, Noninfiltrating therapy
Abstract

Objective: To evaluate the choice of surgical treatment of ductal carcinoma in situ (DCIS) and its impact on long-term outcomes. Methods: A retrospective analysis of the clinicopathological features and treatment protocol of DCIS patients who underwent surgical treatment in Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine from January 2009 to August 2016 was done. The factors which could affect surgical treatment were analyzed by χ(2) test and Logistic regression. Survival analysis were performed between different surgical approaches. Kaplan-Meier survival curves and Log-rank tests demonstrated the distribution of disease free survival and overall survival. Results: A total of 526 patients were enrolled in this study, 405 cases (77.0%) underwent mastectomy, 121 cases (23.0%) underwent breast-conserving surgery, of which 88 cases received radiotherapy after breast-conserving surgery. It was shown by univariate and multivariate analysis that age>50 years ( OR =0.631, 95% CI: 0.413 to 0.965, P =0.034), first symptom of nipple discharge ( OR =0.316, 95% CI: 0.120 to 0.834, P =0.020), excision biopsy ( OR =1.831, 95% CI: 1.182 to 2.835, P =0.007) and tumor size >3 cm ( OR =0.422, 95% CI: 0.206 to 0.864, P =0.018) were significantly correlated with choice of surgical treatment for breast lesions. Axillary lymph node dissection was performed for 118 cases (22.4%), with sentinel lymph node biopsy for 327 cases (62.2%), and none for 81 cases (15.4%). There was significant statistical difference in the choice of axillary lymph node management in patients of different age (χ(2)=8.124, P =0.017), biopsy type (χ(2)=35.567, P =0.000), breast operation type (χ(2)=149.118, P =0.000) and tumor size (χ(2)=13.394, P =0.010). The 5-year disease free survival rates was 95.7%, 89.6% and 100%, respectively, for mastectomy group, breast-conserving surgery group and breast-conserving surgery plus radiotherapy group. And the 5-year overall survival rates for three groups were 99.0%, 100% and 100%. The differences were not statistically significant ( P =0.427, 0.777). Conclusions: For DCIS patients, age, first symptom and tumor size are independent predictors of breast surgery. The choice of axillary lymph node surgery is influenced by age, biopsy, operation type, and tumor size. Different surgical treatment options has no significant effect on disease-free survival and overall survival in DCIS patients.

Published
2017
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49. [Analysis of the factors influencing adjuvant chemotherapy decisions for triple negative breast cancer].

Author

Hong J, Chen XS, Wu JY, Huang O, Zhu L, He JR, Fang Q, Chen WG, Li YF, and Shen KW

Subjects
Adult, Aged, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast secondary, Chemotherapy, Adjuvant statistics & numerical data, Consensus, Cyclophosphamide administration & dosage, Docetaxel, Epirubicin administration & dosage, Female, Fluorouracil administration & dosage, Humans, Middle Aged, Paclitaxel administration & dosage, Patient Care Team statistics & numerical data, Platinum Compounds administration & dosage, Retrospective Studies, Taxoids administration & dosage, Treatment Outcome, Triple Negative Breast Neoplasms pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Ductal, Breast drug therapy, Decision Making, Triple Negative Breast Neoplasms drug therapy
Abstract

Objective: To analyze adjuvant chemotherapy decisions for triple negative breast cancer (TNBC), and explore the influencing factors in the multidisciplinary treatment (MDT) modality. Methods: A retrospective analysis was performed. The cases with invasive TNBC who underwent surgery and MDT discussion for adjuvant treatment in Ruijin Hospital, from April 2013 to June 2015, were recruited. The patients' clinicopathological characteristics were analyzed and adjuvant treatment suggestions from MDT were obtained. Here the chemotherapy decision alteration was defined as a disagreement in chemotherapy or not, or inconsistence in regimens between the attending doctor and the multidisciplinary team. Results: A total of 194 patients aged ≤70 years old were enrolled in the multidisciplinary discussion, and 187 patients (96.4%) were suggested to receive chemotherapy. When compared the opinions of the attending doctor to suggestions of the multidisciplinary team, we found that the percentage of chemotherapy decision alteration reached 22.7% (39/172), of which 94.9% (37/39) were inconsistence in chemotherapy regimens. There were 119 patients who were recommended to receive epirubicin plus cyclophosphamide (EC) followed by docetaxel (T) or weekly paclitaxel (wP) regimens. Before the announcement of results for the E1199 trial, EC-T accounted for 62.5% (55/88), and EC-wP accounted for 37.5% (33/88) for this group of patients. After that, the proportion of EC-T was decreased to 22.6% (7/31) and proportion of EC-wP increased to 77.4%(24/31) ( P <0.001). In addition, a total of 20 patients were suggested to receive platinum based chemotherapy. The proportions were 9.3% in cases with invasive ductal carcinoma, and 33.3% in cases with metaplastic carcinoma, respectively ( P =0.016). Conclusions: The adjuvant chemotherapy decision for TNBC patients is altered in 22.7% of the patients after MDT discussion. After the announcement of SABCS E1199 results, more patients are suggested to receive EC followed by weekly paclitaxel. There is a lack of detailed evidence for platinum based adjuvant chemotherapy for TNBC, and more patients with metaplastic carcinoma receive platinum based adjuvant chemotherapy.

Published
2017
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50. [Factors related to adjuvant ovarian function suppression in premenopausal breast cancer patients].

Author

Liang Y, Chen XS, Wu JY, Huang O, Zong Y, Nie LJ, Fang Q, He JR, Zhu L, Chen WG, Li YF, and Shen KW

Subjects
Adjuvants, Immunologic, Adult, Age Factors, Aromatase Inhibitors therapeutic use, Breast Neoplasms chemistry, Breast Neoplasms physiopathology, Female, Humans, Middle Aged, Ovary physiopathology, Tamoxifen therapeutic use, Androstadienes therapeutic use, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Estrogen Antagonists therapeutic use, Ovary drug effects, Premenopause
Abstract

Objective: To analyze the applied condition of ovary function suppression (OFS) before and after joint analysis of TEXT and SOFT trials and SOFT trial, and to identify the relevant factors of OFS usage., Methods: The analysis was performed in premenopausal women with hormone receptor (HR) positive breast cancer receiving surgical treatment from Apr 2013 to Oct 2015 in Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Adjuvant treatment strategy was made in the multidisciplinary team (MDT) meetings. We analyzed the applied condition of OFS before and after joint analysis, SOFT trial and its relevant factors., Results: Among 454 patients, 114 (25.1%) patients received OFS. Before the results of joint analysis came out, all the patients (38/38) received OFS together with tamoxifen (TAM); after the results came out, clinicians began to put OFS with exemestane into practice, among 76 patients, 41(53.9%) patients received OFS with exemestane while 35 (46.1%) patients received OFS together with TAM. Before the results of SOFT trial came out, 71 out of 310 (22.9%) patients received OFS while 43 out of 144 (29.9%) patients received OFS after that. No significant difference was found between the proportion of patients receiving OFS before and after the results of SOFT trial came out (P=0.112). Age, histological grade, pN status, Ki-67 status, molecular subtype and acceptance of chemotherapy were correlated with OFS treatment (P<0.05). Age, tumor grade and pN were independent significant predictors of OFS usage., Conclusions: After the results of joint analysis came out, clinicians began to apply OFS with exemestane to premenopausal women with HR positive breast cancer. There is no significant difference between the proportion of patients receiving OFS before and after SOFT trial. Age, tumor grade and pN status are independent significant predictors of OFS treatment. Patients younger than 40, with histological grade Ⅱ or Ⅲ tumor and with pN1 or pN2 status are prone to receive OFS.

Published
2016
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