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512 results on '"He, Bangshun"'

17. Inhalation of Bioorthogonal Gene‐Editable Spiky‐Pollen Reprograms Tumor‐Associated Macrophages for Lung Cancer Immunotherapy.

Author

Lu, Qianglan, Chen, Ruiyue, Zeng, Fei, Liu, Zhiyong, Pan, Yongchun, Gao, Yanfeng, He, Bangshun, and Song, Yujun

Abstract

As a major component of tumor infiltration, tumor‐associated macrophages (TAMs) primarily promote the M2 phenotype of tumors in the tumor microenvironment. Additionally, the overexpression of anti‐phagocytic molecules in TAMs facilitates tumor cell evasion of TAMs' phagocytic arrest. Therefore, there is an urgent need to develop a reliable strategy to reprogram TAMs for more effective anti‐tumor outcomes. In this study, innovative inhalable bioorthogonal gene‐editable microparticles (SPR) have been engineered that reprogram TAMs for lung cancer therapy based on spike‐covered sunflower sporopollenin exine capsules (SECs). These microparticles utilize SECs as delivery vehicles, with reduced palladium (Pd) nanoparticles on their surface carrying CRISPR/Cas9 lipid nanoparticles (LNP‐RNPs) that specifically knock down the anti‐phagocytic SIRPα gene on TAMs. The SPR microparticles employ a tripartite strategy to reprogram the TAMs: the physical stimulation through pollen spikes, the production of a Toll‐like receptor 7 agonist (imiquimod, IMD) via Pd‐mediated bioorthogonal catalysis, and the employment of CRISPR/Cas9 gene editing. In an orthotopic mouse model, the inhalation of SPR microparticles not only reprograms macrophages efficiently but also bolsters their tumor‐fighting abilities. Notably, the cured mice show no signs of recurrence even upon re‐exposure to the tumor, indicating a long‐lasting anti‐tumor effect. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy

Author

Zeng, Fei, primary, Pan, Yongchun, additional, Wu, Mengnan, additional, Lu, Qianglan, additional, Qin, Shurong, additional, Gao, Yanfeng, additional, Luan, Xiaowei, additional, Chen, Ruiyue, additional, He, Guanzhong, additional, Wang, Yuzhen, additional, He, Bangshun, additional, Chen, Zhaowei, additional, and Song, Yujun, additional

Published
2024
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29. Association Between Polymorphisms in DNA Damage Repair Pathway Genes and Female Breast Cancer Risk.

Author

Wang, Ying, Sun, Yalan, Tan, Mingjuan, Lin, Xin, Tai, Ping, Huang, Xiaoqin, Jin, Qing, Yuan, Dan, Xu, Tao, and He, Bangshun

Subjects
SINGLE nucleotide polymorphisms, BRCA genes, DISEASE risk factors, DNA repair, DNA damage, EPIDERMAL growth factor
Abstract

Breast cancer risk have been discussed to be associated with polymorphisms in genes as well as abnormal DNA damage repair function. This study aims to assess the relationship between genes single nucleotide polymorphisms (SNPs) related to DNA damage repair and female breast cancer risk in Chinese population. A case–control study containing 400 patients and 400 healthy controls was conducted. Genotype was identified using the sequence MassARRAY method and expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) in tumor tissues was analyzed by immunohistochemistry assay. The results revealed that ATR rs13091637 decreased breast cancer risk influenced by ER, PR (CT/TT vs. CC: adjusted odds ratio [OR] = 1.54, 95% confidence interval [CI]: 1.04–2.27, p = 0.032; CT/TT vs. CC: adjusted OR = 1.63, 95%CI: 1.14–2.35, p = 0.008) expression. Stratified analysis revealed that PALB2 rs16940342 increased breast cancer risk in response to menstrual status (AG/GG vs. AA: adjusted OR = 1.72, 95%CI: 1.13–2.62, p = 0.011) and age of menarche (AG/GG vs. AA: adjusted OR = 1.54, 95%CI: 1.03–2.31, p = 0.037), whereas ATM rs611646 and Ku70 rs132793 were associated with reduced breast cancer risk influenced by menarche (GA/AA vs. GG: adjusted OR = 0.50, 95%CI: 0.30–0.95, p = 0.033). In a summary, PALB2 rs16940342, ATR rs13091637, ATM rs611646, and Ku70 rs132793 were associated with breast cancer risk. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Phenotype and genotype analysis for Helicobacter pylori antibiotic resistance in outpatients: a retrospective study

Author

Xiong, Mengqiu, primary, Mohammed Aljaberi, Hend Sadeq, additional, Khalid Ansari, Nida, additional, Sun, Yalan, additional, Yin, Sijie, additional, Nasifu, Lubanga, additional, Sun, Huiling, additional, Xu, Tao, additional, Pan, Yuqin, additional, Nie, Zhenlin, additional, Liu, Caidong, additional, Zhang, Zhenyu, additional, Jiang, Zongdan, additional, Wang, Shukui, additional, and He, Bangshun, additional

Published
2023
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