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4. Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study

Author

Atas, Nuh, Armagan, Berkan, Bodakci, Erdal, Satis, Hasan, Sari, Alper, Bilge, Nazife Sule Yasar, Salman, Reyhan Bilici, Yardımcı, Gozde Kubra, Babaoglu, Hakan, Guler, Aslihan Avanoglu, Karadeniz, Hazan, Kilic, Levent, Ozturk, Mehmet Akif, Goker, Berna, Haznedaroglu, Seminur, Kalyoncu, Umut, Kasifoglu, Timucin, and Tufan, Abdurrahman

Published
2020
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12. COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease.

Author

Guler, Aslihan Avanoglu, Inel, Tuba Yuce, Kasifoglu, Timucin, Coskun, Cansu, Karadeniz, Hazan, Yildirim, Derya, Bilici, Reyhan, Satis, Hasan, Kucuk, Hamit, Haznedaroglu, Seminur, Goker, Berna, Ozturk, Mehmet Akif, Sari, Ismail, and Tufan, Abdurrahman

Subjects
FAMILIAL Mediterranean fever, COVID-19
Abstract

Objectives: To evaluate the impact of familial Mediterranean fever (FMF) features on the clinical course and outcomes of coronavirus disease 2019 (COVID-19) and clinical course of FMF after COVID-19. Methods: Consecutive FMF patients with COVID-19 were enrolled from three referral hospitals. Clinical features of FMF and detailed COVID-19 information were obtained from patient interviews and medical records. Results: Seventy-three FMF patients were included in the study. 94.5% of patients had clinical symptoms of COVID-19. We found 24.7% hospitalization, 12.3% respiratory support, 4.1% intensive care unit admission, 6.8% complication, and 1.4% mortality rate in patients. The risk factors of hospitalization for respiratory support were male gender [OR: 7.167 (95% CI: 1.368-37.535)], greater age [OR: 1.067 (95% CI: 1.016-1.121)], and non-adherence to colchicine treatment before the infection [OR: 7.5 (95% CI: 1.348-41.722)]. One-third of patients had reported attacks after COVID-19. The patterns of triggered attacks were fever, peritonitis, pleuritis, transient arthritis, chronic knee mono-arthritis, and protracted febrile myalgia. Conclusions: FMF characteristics were not associated with worse outcomes of COVID-19. Colchicine non-adherence was the risk factor of hospitalization for oxygen support. The rate of FMF attacks after COVID-19 is prominently increased, with some of them being protracted and destructive. [ABSTRACT FROM AUTHOR]

Published
2023
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13. COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease

Author

Avanoglu Guler, Aslihan, primary, Yuce Inel, Tuba, additional, Kasifoglu, Timucin, additional, Coskun, Cansu, additional, Karadeniz, Hazan, additional, Yildirim, Derya, additional, Bilici, Reyhan, additional, Satis, Hasan, additional, Kucuk, Hamit, additional, Haznedaroglu, Seminur, additional, Goker, Berna, additional, Ozturk, Mehmet Akif, additional, Sari, Ismail, additional, and Tufan, Abdurrahman, additional

Published
2022
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15. Long-term safety and efficacy of anakinra and canakinumab in patients with familial Mediterranean fever: a single-centre real-life study with 101 patients

Author

Atas, Nuh, primary, Eroglu, Gulsah Atbiner, additional, Sodan, Hulya Nur, additional, Ozturk, Beyza Olcay, additional, Babaoglu, Hakan, additional, Satis, Hasan, additional, Karadeniz, Hazan, additional, Guler, Aslihan Avanoglu, additional, Salman, Reyhan Bilici, additional, Goker, Berna, additional, Ozturk, Mehmet Akif, additional, Haznedaroglu, Seminur, additional, and Tufan, Abdurrahman, additional

Published
2021
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17. Does hydroxychloroquine improve patient reported outcomes in patients with lupus?

Author

Jolly, Meenakshi, primary, Sehgal, Vinay, additional, Arora, Shilpa, additional, Azizoddin, Desiree, additional, Pinto, Benzeeta, additional, Sharma, Aman, additional, Devilliers, Herve, additional, Inoue, Mitsuyo, additional, Toloza, Sergio, additional, Bertoli, Ana, additional, Blazevic, Ivana, additional, Vilá, Luis M, additional, Moldovan, Ioana, additional, Torralba, Karina D, additional, Mazzoni, Davide, additional, Cicognani, Elvira, additional, Hasni, Sarfaraz, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Bourre-Tessier, Josiane, additional, Navarra, Sandra V, additional, Clarke, Ann, additional, Weisman, Michael, additional, Wallace, Daniel, additional, and Mok, Chi Chiu, additional

Published
2021
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23. Azathioprine for The Induction Treatment of Connective Tissue Disorder Related Interstitial Lung Disease and Comparison with Cyclophosphamide: a retrospective cohort analysis

Author

Satış, Hasan, primary, Onut, Mehmet, additional, Baysan, Caner, additional, Salman, Reyhan Bilici, additional, Yapar, Dilek, additional, Babaoğlu, Hakan, additional, Ataş, Nuh, additional, Güler, Aslıhan Avanoğlu, additional, Karadeniz, Hazan, additional, Küçük, Hamit, additional, Haznedaroglu, Seminur, additional, GOKER, BURCU, additional, Öztürk, Mehmet Akif, additional, Tufan, Abdurrahman, additional, Demirci, Nilgün Yılmaz, additional, and Türktaş, Haluk, additional

Published
2021
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25. Predictors of persistent inflammation in familial Mediterranean fever and association with damage

Author

Babaoglu, Hakan, primary, Armagan, Berkan, additional, Bodakci, Erdal, additional, Satis, Hasan, additional, Atas, Nuh, additional, Sari, Alper, additional, Yasar Bilge, Nazife Sule, additional, Bilici Salman, Reyhan, additional, Yardımcı, Gozde Kubra, additional, Avanoglu Guler, Aslihan, additional, Karadeniz, Hazan, additional, Kilic, Levent, additional, Ozturk, Mehmet Akif, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Kalyoncu, Umut, additional, Kasifoglu, Timucin, additional, and Tufan, Abdurrahman, additional

Published
2020
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30. Drivers of Satisfaction With Care for Patients With Lupus

Author

Jolly, M, Sethi, B, O'Brien, C, Sequeira, W, Block, J, Toloza, S, Bertoli, A, Blazevic, I, Vilá, L, Moldovan, I, Torralba, K, Cicognani, E, Mazzoni, D, Hasni, S, Goker, B, Haznedaroglu, S, Bourre‐tessier, J, Navarra, S, Mok, C, Clarke, A, Weisman, M, Wallace, D, Jolly, Meenakshi, Sethi, Bhavika, O'Brien, Courtney, Sequeira, Winston, Block, Joel A., Toloza, Sergio, Bertoli, Ana, Blazevic, Ivana, Vilá, Luis M., Moldovan, Ioana, Torralba, Karina D., Cicognani, Elvira, Mazzoni, Davide, Hasni, Sarfaraz, Goker, Berna, Haznedaroglu, Seminur, Bourre‐Tessier, Josiane, Navarra, Sandra V., Mok, Chi Chiu, Clarke, Ann, Weisman, Michael, Wallace, Daniel, Jolly, M, Sethi, B, O'Brien, C, Sequeira, W, Block, J, Toloza, S, Bertoli, A, Blazevic, I, Vilá, L, Moldovan, I, Torralba, K, Cicognani, E, Mazzoni, D, Hasni, S, Goker, B, Haznedaroglu, S, Bourre‐tessier, J, Navarra, S, Mok, C, Clarke, A, Weisman, M, Wallace, D, Jolly, Meenakshi, Sethi, Bhavika, O'Brien, Courtney, Sequeira, Winston, Block, Joel A., Toloza, Sergio, Bertoli, Ana, Blazevic, Ivana, Vilá, Luis M., Moldovan, Ioana, Torralba, Karina D., Cicognani, Elvira, Mazzoni, Davide, Hasni, Sarfaraz, Goker, Berna, Haznedaroglu, Seminur, Bourre‐Tessier, Josiane, Navarra, Sandra V., Mok, Chi Chiu, Clarke, Ann, Weisman, Michael, and Wallace, Daniel

Abstract

Objective: Quality of life (QOL) and quality of care (QOC) in systemic lupus erythematosus (SLE) remains poor. Satisfaction with care (SC), a QOC surrogate, correlates with health behaviors and outcomes. This study aimed to determine correlates of SC in SLE. Methods: A total of 1262 patients with SLE were recruited from various countries. Demographics, disease activity (modified Systemic Lupus Erythematosus Disease Activity Index for the Safety of Estrogens in Lupus Erythematosus: National Assessment trial [SELENA-SLEDAI]), and QOL (LupusPRO version 1.7) were collected. SC was collected using LupusPRO version 1.7. Regression analyses were conducted using demographic, disease (duration, disease activity, damage, and medications), geographic (eg, China vs United States), and QOL factors as independent predictors. Results: The mean (SD) age was 41.7 (13.5) years; 93% of patients were women. On the univariate analysis, age, ethnicity, current steroid use, disease activity, and QOL (social support, coping) were associated with SC. On the multivariate analysis, Asian participants had worse SC, whereas African American and Hispanic patients had better SC. Greater disease activity, better coping, and social support remained independent correlates of better SC. Compared with US patients, patients from China and Canada had worse SC on the univariate analysis. In the multivariate models, Asian ethnicity remained independently associated with worse SC, even after we adjusted for geographic background (China). No associations between African American or Hispanic ethnicity and SC were retained when geographic location (Canada) was added to the multivariate model. Canadian patients had worse SC when compared with US patients. Higher disease activity, better social support, and coping remained associated with better SC. Conclusion: Greater social support, coping, and, paradoxically, SLE disease activity are associated with better SC. Social support and coping are modifiable factors

Published
2019

32. Drivers of Satisfaction With Care for Patients With Lupus

Author

Jolly, Meenakshi, primary, Sethi, Bhavika, additional, O'Brien, Courtney, additional, Sequeira, Winston, additional, Block, Joel A., additional, Toloza, Sergio, additional, Bertoli, Ana, additional, Blazevic, Ivana, additional, Vilá, Luis M., additional, Moldovan, Ioana, additional, Torralba, Karina D., additional, Cicognani, Elvira, additional, Mazzoni, Davide, additional, Hasni, Sarfaraz, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Bourre‐Tessier, Josiane, additional, Navarra, Sandra V., additional, Mok, Chi Chiu, additional, Clarke, Ann, additional, Weisman, Michael, additional, and Wallace, Daniel, additional

Published
2019
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33. Familial Mediterranean fever-associated infertility and underlying factors

Author

Atas, Nuh, primary, Armagan, Berkan, additional, Bodakci, Erdal, additional, Satis, Hasan, additional, Sari, Alper, additional, Bilge, Nazife Sule Yasar, additional, Salman, Reyhan Bilici, additional, Yardımcı, Gozde Kubra, additional, Babaoglu, Hakan, additional, Kilic, Levent, additional, Ozturk, Mehmet Akif, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Kasifoglu, Timucin, additional, Kalyoncu, Umut, additional, and Tufan, Abdurrahman, additional

Published
2019
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34. Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study

Author

Atas, Nuh, primary, Armagan, Berkan, additional, Bodakci, Erdal, additional, Satis, Hasan, additional, Sari, Alper, additional, Bilge, Nazife Sule Yasar, additional, Salman, Reyhan Bilici, additional, Yardımcı, Gozde Kubra, additional, Babaoglu, Hakan, additional, Guler, Aslihan Avanoglu, additional, Karadeniz, Hazan, additional, Kilic, Levent, additional, Ozturk, Mehmet Akif, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Kalyoncu, Umut, additional, Kasifoglu, Timucin, additional, and Tufan, Abdurrahman, additional

Published
2019
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35. FRI0617 APPLICATION OF AUTO-INFLAMMATORY DISEASE DAMAGE INDEX (ADDI) TO PATIENTS WITH FMF AND RELATED FACTORS WITH DAMAGE

Author

Babaoglu, Hakan, primary, Armagan, Berkan, additional, Bodakci, Erdal, additional, Kaşifoğlu, Timuçin, additional, Satış, Hasan, additional, Atas, Nuh, additional, Sarı, Alper, additional, Yasar Bilge, Nazife Sule, additional, Yardımcı, Gözde Kübra, additional, Salman, Reyhan Bilici, additional, Kılıç, Levent, additional, Ozturk, Mehmet Akif, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Kalyoncu, Umut, additional, and tufan, abdurrahman, additional

Published
2019
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36. THU0589 FREQUENCY, CHARACTERISTICS AND CLINICAL DETERMINANTS OF “PRODROME” IN FAMILIAL MEDITERRANEAN FEVER PATIENTS

Author

Babaoglu, Hakan, primary, Atas, Nuh, additional, Varan, Ozkan, additional, Satış, Hasan, additional, Salman, Reyhan Bilici, additional, Güler, Aslıhan Avanoglu, additional, Karadeniz, Hazan, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Ozturk, Mehmet Akif, additional, and tufan, abdurrahman, additional

Published
2019
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37. AB0555 POTENTIAL ROLE OF PAROTID ELASTOGRAPHY IN DIAGNOSIS AND CLASSIFICATION OF PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME

Author

Satış, Hasan, primary, Demir, Betül Nur, additional, Salman, Reyhan Bilici, additional, Temel, Esra, additional, Babaoglu, Hakan, additional, Atas, Nuh, additional, Güler, Aslıhan Avanoglu, additional, Karadeniz, Hazan, additional, Cingil, Emetullah, additional, Tufan, Abdurrahman, additional, Ozturk, Mehmet Akif, additional, Haznedaroglu, Seminur, additional, and Göker, Berna, additional

Published
2019
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38. SAT0536 DIAGNOSTIC UTILITY OF POSITRON EMISSION TOMOGRAPHY FOR THE EVALUATION OF PATIENTS WITH INFLAMMATION OF UNKNOWN ORIGIN

Author

bilici salman, reyhan, primary, Gülbahar, Seda, additional, Satiş, Hasan, additional, Atas, Nuh, additional, Babaoglu, Hakan, additional, Karadeniz, Hazan, additional, Güler, Aslihan Avanoglu, additional, Akdemir, Umit Ozgur, additional, Tufan, Abdurrahman, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Atay, Lutfiye Ozlem, additional, and Ozturk, Mehmet Akif, additional

Published
2019
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42. Predictors of persistent inflammation in familial Mediterranean fever and association with damage.

Author

Babaoglu, Hakan, Armagan, Berkan, Bodakci, Erdal, Satis, Hasan, Atas, Nuh, Sari, Alper, Bilge, Nazife Sule Yasar, Salman, Reyhan Bilici, Yardımcı, Gozde Kubra, Guler, Aslihan Avanoglu, Karadeniz, Hazan, Kilic, Levent, Ozturk, Mehmet Akif, Goker, Berna, Haznedaroglu, Seminur, Kalyoncu, Umut, Kasifoglu, Timucin, and Tufan, Abdurrahman

Subjects
GENETIC disorders, INFLAMMATION, INFLAMMATORY bowel diseases, SPONDYLOARTHROPATHIES, LOGISTIC regression analysis, CROSS-sectional method, DISEASE complications
Abstract

Objective Persistent inflammation is an insidious and less studied feature of FMF. We investigated clinical determinants of persistent inflammation and its associations with individual damage items. Methods This is a cross-sectional analysis of 917 FMF patients, who fulfilled the Tel Hashomer criteria and had at least 6 months' follow-up. Patients were stratified based on whether they had persistent inflammation. We used logistic regression analysis to investigate independent predictors of persistent inflammation and the associated individual damage items. Results One hundred and forty-two (15%) patients had persistent inflammation. Active FMF (54%) was the most prominent reason for the persistent inflammation. Spondylarthritis (16%), other inflammatory arthritis (8%) and IBD (2%) were other frequent reasons. Male gender, history of exertional leg pain, inflammatory comorbidities, M694V homozygosity, colchicine resistance, lower education levels and musculoskeletal attack dominance were found to be the independent predictors of persistent inflammation. Earlier disease onset led to a tendency towards persistent inflammation. Patients with persistent inflammation were more likely to suffer damage. There is an increased risk of developing proteinuria, amyloidosis and renal insufficiency. Conclusion We identified, for the first time, the predictors of persistent inflammation in adult FMF patients and related individual damage items of the Autoinflammatory Disease Damage Index. Persistent inflammation is insidious and one of the chief causes of damage; therefore, especially patients with these predictors should be followed up more closely. If detected, underlying inflammatory comorbidities should be assessed meticulously as early detection and proper treatment strategies may favourably impact the natural history of the disease. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Inter‐rater reliability of modified hand mobility in scleroderma test.

Author

Tore, Nurten Gizem, Sari, Fulden, Sarac, Devrim Can, Baglan Yentur, Songul, Satis, Hasan, Avanoglu Guler, Aslihan, Haznedaroglu, Seminur, and Oskay, Deran

Subjects
SYSTEMIC scleroderma, ETIOLOGY of diseases, TEST reliability, AUTOIMMUNE diseases, ENDOTHELIAL cells
Abstract

Aim: Systemic sclerosis (SSc) is a chronic autoimmune disease of unknown etiology characterized by excessive collagen production, endothelial cell injury, microvascular obliteration, cutaneous fibrosis and progressive visceral disease. The hands are frequently involved during the progression of the disease, with symmetrical skin thickening as a prominent feature. Modified hand mobility in scleroderma (mHAMIS) test is a measurement method to assess hand mobility in patients with SSc. Knowing the inter‐rater reliability of the instrument is important in order for the results from different examiners to be accurately interpreted. The aim of this study was to test inter‐rater reliability of the mHAMIS test. Method: Hand mobility for both hands was assessed in 25 female patients with SSc by 2 physiotherapists who have different years of experience. Patients who had flexion contracture in at least 1 finger and undergone hand surgery in the last year due to any injuries, were excluded from the study since hand mobility was prevented. Inter‐rater reliability was determined using intra‐class correlation coefficients (ICCs). Result: The ICCs were excellent between raters for dominant and non‐dominant hands. The values were 0.92 and 0.93, respectively. Conclusion: The inter‐rater reliability of the mHAMIS was found to be excellent. This research contributes to the literature by proving that the test can be used without causing bias in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Sex Differences in Quality of Life in Patients With Systemic Lupus Erythematosus

Author

Jolly, Meenakshi, primary, Sequeira, Winston, additional, Block, Joel A., additional, Toloza, Sergio, additional, Bertoli, Ana, additional, Blazevic, Ivanna, additional, Vila, Luis M., additional, Moldovan, Ioana, additional, Torralba, Karina D., additional, Mazzoni, Davide, additional, Cicognani, Elvira, additional, Hasni, Sarfaraz, additional, Goker, Berna, additional, Haznedaroglu, Seminur, additional, Bourre‐Tessier, Josiane, additional, Navarra, Sandra V., additional, Mok, Chi Chiu, additional, Weisman, Michael, additional, Clarke, Ann E., additional, Wallace, Daniel, additional, and Alarcón, Graciela, additional

Published
2018
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50. Selectin adhesion molecules in Behcet's disease

Author

Haznedaroglu, Seminur, Karaaslan, Yasar, Buyukasik, Yahya, Kosar, Ali, Ozcebe, Osman I., Haznedaroglu, Ibrahim C., Kirazli, Serafettin, and Dundar, Semra V.

Subjects
Behcet's disease -- Physiological aspects, Cell adhesion molecules -- Physiological aspects, Health
Abstract

Patients with Behcet's disease have elevated blood levels of selectin adhesion molecules. Behcet's disease is an inflammation of blood vessels that has no known cause. Selectins are molecules that allow cells to bind to other cells.

Published
2000

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