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1. OP0064 CHARACTERIZING PREVALENT NON-ARTICULAR PAIN AT EARLY RA DIAGNOSIS AND EVOLUTION OVER THE FIRST YEAR OF RA TREATMENT: RESULTS FROM THE CANADIAN EARLY ARTHRITIS COHORT STUDY

Author

Meng, C., primary, Lee, Y., additional, Schieir, O., additional, Valois, M. F., additional, Butler, M., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C. A., additional, Keystone, E., additional, Tin, D., additional, Thorne, C., additional, Bessette, L., additional, Pope, J., additional, Bartlett, S. J., additional, and Bykerk, V., additional

Published
2024
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2. POS0471 SPECIFIC SYMPTOM CLUSTERS AT DIAGNOSIS SIGNAL A POORER EARLY RA PROGNOSIS: DATA FROM THE CANADIAN EARLY ARTHRITIS COHORT

Author

Bartlett, S. J., primary, Bingham, C. O., additional, Schieir, O., additional, Valois, M. F., additional, Boire, G., additional, Pope, J., additional, Bessette, L., additional, Thorne, C., additional, Tin, D., additional, Hitchon, C., additional, Hazlewood, G., additional, Keystone, E., additional, and Bykerk, V., additional

Published
2023
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3. POS0458 HAVING MORE TENDER THAN SWOLLEN JOINTS IS ASSOCIATED WITH WORSE FUNCTION, PAIN INTERFERENCE, SOCIAL PARTICIPATION AND OTHER HR-QOL OUTCOMES IN THE FIRST YEAR FOLLOWING RA DIAGNOSIS: RESULTS FROM THE CANADIAN EARLY ARTHRITIS COHORT STUDY

Author

Meng, C., primary, Lee, Y., additional, Schieir, O., additional, Valois, M. F., additional, Butler, M., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C., additional, Keystone, E., additional, Tin, D., additional, Thorne, C., additional, Bessette, L., additional, Pope, J., additional, Bartlett, S. J., additional, and Bykerk, V., additional

Published
2023
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4. POS0584-HPR PROS AND DISEASE ACTIVITY IN YEAR PRIOR TO COVID PREDICT TRAJECTORIES OF DEPRESSION IN ADULTS WITH RA IN FIRST 2 YEARS OF PANDEMIC: DATA FROM THE CANADIAN EARLY ARTHRITIS COHORT

Author

Bartlett, S. J., primary, Schieir, O., additional, Valois, M. F., additional, Pope, J., additional, Bessette, L., additional, Boire, G., additional, Hitchon, C., additional, Keystone, E., additional, Thorne, C., additional, Tin, D., additional, Hazlewood, G., additional, and Bykerk, V., additional

Published
2023
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6. OP0308-HPR MORE THAN HALF OF RA PATIENTS WITH A LIFETIME HISTORY OF MOOD DISORDERS WERE ANXIOUS AND DEPRESSED DURING THE COVID-19 PANDEMIC: RESULTS FROM THE CANADIAN EARLY COHORT (CATCH) STUDY

Author

Bartlett, S. J., primary, Schieir, O., additional, Valois, M. F., additional, Boire, G., additional, Hazlewood, G., additional, Thorne, C., additional, Tin, D., additional, Hitchon, C., additional, Pope, J., additional, Keystone, E., additional, Bessette, L., additional, and Bykerk, V., additional

Published
2022
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9. Methods to Summarize Discrete-Choice Experiments in a Systematic Review: A Scoping Review

Author

Choudhary, D, Thomas, M, Pacheco-Barrios, K, Zhang, Y, Alonso-Coello, P, Schunemann, H, and Hazlewood, G

Abstract

Background and Objective Systematic reviews of discrete-choice experiments (DCEs) are being increasingly conducted. The objective of this scoping review was to identify and describe the methodologies that have been used to summarize results across DCEs. Methods We searched the electronic databases MEDLINE and EMBASE from inception to March 18, 2021, to identify English-language systematic reviews of patient preferences that included at least two DCEs and extracted data on attribute importance. The methods used to summarize results across DCEs were classified into narrative, semi-quantitative, and quantitative (meta-analytic) approaches and compared. Approaches to characterize the extent of preference heterogeneity were also described. Results From 7362 unique records, we identified 54 eligible reviews from 2010 to Mar 2021, across a broad range of health conditions. Most (83%) used a narrative approach to summarize findings of DCEs, often citing differences in studies as the reason for not formally pooling findings. Semi-quantitative approaches included summarizing the frequency of the most important attributes, the frequency of attribute statistical significance, or tabulated comparisons of attribute importance for each pair of attributes. One review conducted a meta-analysis using the maximum acceptable risk. While reviews often commented on the heterogeneity of patient preferences, few (6%) addressed this systematically across studies. Conclusion While not commonly used, several semi-quantitative and one quantitative approach for synthesizing results of DCEs were identified, which may be useful for generating summary estimates across DCEs when appropriate. Further work is needed to assess the validity and usefulness of these approaches.

Published
2022

11. Palindromic Rheumatism Frequently Precedes Early Rheumatoid Arthritis: Results From an Incident Cohort

Author

Ellingwood, L., Schieir, O., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Keystone, E. C., Tin, D., Thorne, C., Bykerk, V. P., Pope, J. E., Baron, Murray, Bessette, Louis, Boire, Gilles, Bykerk, Vivian, Colmegna, Ines, Fallavollita, Sabrina, Haaland, Derek, Haraoui, Paul, Hazlewood, Glen, Hitchon, Carol, Jamal, Shahin, Joshi, Raman, Keystone, Ed, Nair, Bindu, Panopoulos, Peter, Pope, Janet, Rubin, Laurence, Thorne, Carter, Villeneuve, Edith, and Zummer, Michel

Subjects
medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, business.industry, Swollen joints, General Medicine, Early rheumatoid arthritis, Original Articles, Logistic regression, Clinical disease, medicine.disease, Joint pain, Internal medicine, Cohort, Medicine, Original Article, Palindromic rheumatism, lcsh:RC925-935, medicine.symptom, business, Early arthritis
Abstract

Background This multicenter incident cohort aimed to characterize how often early rheumatoid arthritis (ERA) patients self‐report episodic joint inflammation (palindromic rheumatism) preceding ERA diagnosis and which characteristics differentiate these patients from those without prior episodic symptoms. Methods Data were from patients with early confirmed or suspected RA (more than 6 weeks and less than 12 months) enrolled in the Canadian Early ArThritis CoHort (CATCH) between April 2017 to March 2018 who completed study case report forms assessing joint pain and swelling prior to ERA diagnosis. Chi‐square and t tests were used to compare characteristics of patients with and without self‐reported episodic joint inflammation prior to ERA diagnosis. Multivariable logistic regression was used to identify sociodemographic and clinical measures associated with past episodic joint inflammation around the time of ERA diagnosis. Results A total of 154 ERA patients were included; 66% were female, and mean (SD) age and RA symptom duration were 54 (15) years and 141 (118) days. Sixty‐five (42%) ERA patients reported a history of episodic joint pain and swelling, half of whom reported that these symptoms preceded ERA diagnosis by over 6 months. ERA patients with past episodic joint inflammation were more often female, had higher income, were seropositive, had more comorbidities, fewer swollen joints, and lower Clinical Disease Activity Index (CDAI) around the time of ERA diagnosis (P < 0.05). These associations remained significant in multivariable regression adjusting for other sociodemographic and RA clinical measures. Conclusion Almost half of ERA patients experienced episodic joint inflammation prior to ERA diagnosis. These patients were more often female, had higher income, and presented with milder disease activity at ERA diagnosis.

Published
2019

14. Validity of the Health Assessment Questionnaire Predicting All‐Cause Mortality in Early Rheumatoid Arthritis: Reply to three letters to the editor

Author

Fatima, Safoora, primary, Schieir, O., additional, Valois, M.F., additional, Bartlett, S.J., additional, Bessette, L., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C., additional, Keystone, E.C., additional, Tin, D., additional, Thorne, C., additional, Bykerk, V.P., additional, Pope, J.E., additional, and Investigators, CATCH, additional

Published
2021
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17. OP0262-HPR THE NEURO-QOL UPPER EXTREMITY FUNCTION SCALE: NEW OPPORTUNITIES TO MORE RELIABLY AND PRECISELY MEASURE SELF-REPORTED HAND FUNCTION AND SELF-CARE ACTIVITIES IN PEOPLE WITH RA

Author

Bartlett, S. J., primary, Schieir, O., additional, Valois, M. F., additional, Boire, G., additional, Pope, J., additional, Keystone, E., additional, Thorne, C., additional, Tin, D., additional, Hitchon, C., additional, Bessette, L., additional, Hazlewood, G., additional, and Bykerk, V., additional

Published
2021
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18. POS0531 FACTORS ASSOCIATED WITH BASELINE HYPERTENSION IN EARLY RHEUMATOID ARTHRITIS: DATA FROM A REAL-WORLD LARGE INCIDENT COHORT

Author

Hadwen, B., primary, Stranges, S., additional, Klar, N., additional, Bindee, K., additional, Pope, J., additional, Bartlett, S. J., additional, Boire, G., additional, Bessette, L., additional, Hitchon, C., additional, Hazlewood, G., additional, Keystone, E., additional, Schieir, O., additional, Thorne, C., additional, Tin, D., additional, Valois, M. F., additional, Bykerk, V., additional, and Barra, L., additional

Published
2021
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21. FRI0030 MORE THAN HALF OF NEWLY DIAGNOSED RA PATIENTS ARE NOT CONVINCED OF THE NECESSITY OF RA MEDICINES: ASSOCIATIONS WITH RA CHARACTERISTICS, SYMPTOMS, AND FUNCTION IN THE CANADIAN EARLY ARTHRITIS COHORT (CATCH)

Author

Ta, V., primary, Schieir, O., additional, Valois, M. F., additional, Hazlewood, G., additional, Hitchon, C., additional, Bessette, L., additional, Tin, D., additional, Thorne, C., additional, Pope, J., additional, Boire, G., additional, Keystone, E., additional, Bykerk, V., additional, and Bartlett, S. J., additional

Published
2020
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24. SAT0053 ESTIMATING REAL-WORLD UNMET NEEDS FOR REACHING REMISSION IN THE FIRST YEAR FOLLOWING EARLY RA DIAGNOSIS: RESULTS FROM THE CANADIAN EARLY ARTHRITIS COHORT (CATCH)

Author

Schieir, O., primary, Bartlett, S. J., additional, Valois, M. F., additional, Bessette, L., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C., additional, Keystone, E., additional, Pope, J., additional, Thorne, C., additional, Tin, D., additional, and Bykerk, V., additional

Published
2020
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25. FRI0032 REGIONAL AND WIDESPREAD PATTERNS OF NON-ARTICULAR PAIN ARE COMMON AT RA DIAGNOSIS AND CONTRIBUTE TO POOR OUTCOMES AT 12 MONTHS: A PROSPECTIVE STUDY OF PAIN PATTERNS IN CANADIANS WITH RA

Author

Bykerk, V., primary, Schieir, O., additional, Valois, M. F., additional, Bessette, L., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C., additional, Keystone, E., additional, Tin, D., additional, Thorne, C., additional, Pope, J., additional, and Bartlett, S. J., additional

Published
2020
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27. SAT0127 REAL-WORLD PREDICTORS OF STARTING DIFFERENT ADVANCED DMARD TREATMENTS IN RHEUMATOID ARTHRITIS: A PROSPECTIVE INVESTIGATION FROM THE CANADIAN EARLY ARTHRITIS COHORT (CATCH) GROUP

Author

Weiler, M., primary, Schieir, O., additional, Valois, M. F., additional, Bartlett, S. J., additional, Bessette, L., additional, Boire, G., additional, Hazlewood, G., additional, Hitchon, C., additional, Keystone, E., additional, Tin, D., additional, Thorne, C., additional, Bykerk, V., additional, and Pope, J., additional

Published
2020
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33. GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences-Risk of bias and indirectness

Author

Zhang, Y, Alonso-Coello, P, Guyatt, GH, Yepes-Nunez, JJ, Akl, EA, Hazlewood, G, Pardo-Hernandez, H, Etxeandia-Ikobaltzeta, I, Qaseem, A, Williams, JW, Tugwell, P, Flottorp, S, Chang, YP, Zhanag, YQ, Mustafa, RA, Rojas, MX, and Schunemann, HJ

Subjects
GRADE, Value and preference, Importance of outcomes, Quality of evidence, Indirectness, Risk of bias
Abstract

Objectives: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes. Study Design and Setting: We applied the GRADE domains to rate the certainty of evidence in the importance of outcomes to several systematic reviews, iteratively reviewed draft guidance and consulted GRADE members and other stakeholders for feedback. Results: This is the first of two articles. A body of evidence addressing the importance of outcomes starts at "high certainty"; concerns with risk of bias, indirectness, inconsistency, imprecision, and publication bias lead to downgrading to moderate, low, or very low certainty. We propose subdomains of risk of bias as selection of the study population, missing data, the type of measurement instrument, and confounding; we have developed items for each subdomain. The population, intervention, comparison, and outcome elements associated with the evidence determine the degree of indirectness. Conclusion: This article provides guidance and examples for rating the risk of bias and indirectness for a body of evidence summarizing the importance of outcomes. (C) 2018 Elsevier Inc. All rights reserved.

Published
2019

37. Health Assessment Questionnaire at One Year Predicts All‐Cause Mortality in Patients With Early Rheumatoid Arthritis.

Author

Fatima, Safoora, Schieir, O., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Keystone, E. C., Tin, D., Thorne, C., Bykerk, V. P., Pope, J. E., Baron, Murray, Bessette, Louis, Boire, Gilles, Bykerk, Vivian, Colmegna, Ines, Fallavollita, Sabrina, and Haaland, Derek

Subjects
CONFIDENCE intervals, DISABILITY evaluation, QUESTIONNAIRES, RHEUMATOID arthritis, PROPORTIONAL hazards models, DESCRIPTIVE statistics
Abstract

Objective: Higher self‐reported disability (high Health Assessment Questionnaire [HAQ] score) has been associated with hospitalizations and mortality in established rheumatoid arthritis (RA), but associations in early RA are unknown. Methods: Patients with early RA (symptom duration <1 year) enrolled in the Canadian Early Arthritis Cohort who initiated disease‐modifying antirheumatic drugs and had completed HAQ data at baseline and 1 year were included in the study. Discrete‐time proportional hazards models were used to estimate crude and multi‐adjusted associations of baseline HAQ and HAQ at 1 year with all‐cause mortality in each year of follow‐up. Results: A total of 1,724 patients with early RA were included. The mean age was 55 years, and 72% were women. Over 10 years, 62 deaths (3.6%) were recorded. Deceased patients had higher HAQ scores at baseline (mean ± SD 1.2 ± 0.7) and at 1 year (0.9 ± 0.7) than living patients (1.0 ± 0.7 and 0.5 ± 0.6, respectively; P < 0.001). Disease Activity Score in 28 joints (DAS28) was higher in deceased versus living patients at baseline (mean ± SD 5.4 ± 1.3 versus 4.9 ± 1.4) and at 1 year (mean ± SD 3.6 ± 1.4 versus 2.8 ± 1.4) (P < 0.001). Older age, male sex, lower education level, smoking, more comorbidities, higher baseline DAS28, and glucocorticoid use were associated with mortality. Contrary to HAQ score at baseline, the association between all‐cause mortality and HAQ score at 1 year remained significant even after adjustment for confounders. For baseline HAQ score, the unadjusted hazard ratio (HR) was 1.46 (95% confidence interval [95% CI] 1.02–2.09), and the adjusted HR was 1.25 (95% CI 0.81–1.94). For HAQ score at 1 year, the unadjusted HR was 2.58 (95% CI 1.78–3.72), and the adjusted HR was 1.75 (95% CI 1.10–2.77). Conclusion: Our findings indicate that higher HAQ score and DAS28 at 1 year are significantly associated with all‐cause mortality in a large early RA cohort. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Reply.

Author

Fatima, Safoora, Schieir, O., Keystone, E. C., Valois, M. F., Bartlett, S. J., Bessette, L., Boire, G., Hazlewood, G., Hitchon, C., Tin, D., Thorne, C., Bykerk, V. P., and Pope, J. E.

Subjects
FUNCTIONAL status, RHEUMATOID arthritis
Abstract

The article discusses the predictive capacity in estimating the risk of all-cause mortality among patients with Rheumatoid Arthritis (RA). Topics include HAQ disability index score, with the results showing similar levels of association with mortality but without improvement in the fit of the model; and Rheumatic Disease Comorbidity Index and could increase the rate of all-cause mortality.

Published
2022
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39. Prevalence and Characteristics of Metabolic Syndrome Differ in Men and Women with Early Rheumatoid Arthritis.

Author

Kuriya, B., Schieir, O., Valois, M. F., Pope, J. E., Boire, G., Bessette, L., Hazlewood, G., Thorne, J. C., Tin, D., Hitchon, C., Bartlett, S., Keystone, E. C., Bykerk, V. P., and Barra, L.

Abstract

Objective: Metabolic syndrome (MetS) prevalence in early rheumatoid arthritis (ERA) is conflicting. The impact of sex, including menopause, has not been described. We estimated the prevalence and factors associated with MetS in men and women with ERA. Methods: A cross‐sectional study of the Canadian Early Arthritis Cohort (CATCH) was performed. Participants with baseline data to estimate key MetS components were included. Sex‐stratified logistic regression identified baseline variables associated with MetS. Results: The sample included 1543 participants; 71% were female and the mean age was 54 (SD 15) years. MetS prevalence was higher in men 188 (42%) than women 288 (26%, P < 0.0001) and increased with age. Frequent MetS components in men were hypertension (62%), impaired glucose tolerance (IGT, 40%), obesity (36%), and low high‐density lipoprotein cholesterol (36%). Postmenopausal women had greater frequency of hypertension (65%), IGT (32%), and high triglycerides (21%) compared with premenopausal women (P < 0.001). In multivariate analysis, MetS was negatively associated with seropositivity and pulmonary disease in men. Increasing age was associated with MetS in women. In postmenopausal women, corticosteroid use was associated with MetS. Psychiatric comorbidity was associated with MetS in premenopausal women. MetS status was not explained by disease activity or core RA measures. Conclusion: The characteristics and associations of MetS differed in men and women with ERA. Sex differences, including postmenopausal status, should be considered in comorbidity screening. With this knowledge, the interplay of MetS, sex, and RA therapeutic response on cardiovascular outcomes should be investigated. [ABSTRACT FROM AUTHOR]

Published
2019
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41. A29 THE RISING PREVALENCE OF INFLAMMATORY BOWEL DISEASE IN CANADA: ANALYZING THE PAST TO PREDICT THE FUTURE

Author

Coward, S, primary, Clement, F, additional, Benchimol, E I, additional, Bernstein, C N, additional, Bitton, A, additional, Carroll, M W, additional, Hazlewood, G, additional, Jelinski, S, additional, Jones, J, additional, Kuenzig, E, additional, Leddin, D, additional, McBrien, K, additional, Murthy, S, additional, Nguyen, G C, additional, Otley, A, additional, Rezaie, A, additional, Pena-Sanchez, J, additional, Singh, H, additional, Targownik, L, additional, and Kaplan, G G, additional

Published
2018
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