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3. Training in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder

Author

Denny, Bryan T., Lopez, Richard B., Wu-Chung, E. Lydia, Dicker, Eva E., Goodson, Pauline N., Fan, Jin, Schulz, Kurt P., Ochsner, Kevin N., Trumbull, Jacqueline, Martin Lopez, Maria, Fels, Samuel, Galitzer, Hayley, Perez-Rodriguez, M. Mercedes, Goodman, Marianne, Rosell, Daniel R., Hazlett, Erin A., McClure, Margaret M., New, Antonia S., and Koenigsberg, Harold W.

Published
2024
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25. Role of Peripheral Inflammation in Risk of Suicide

Author

Sun, Shengnan, primary, Liu, Qingkun, additional, Wang, Zhaoyu, additional, Wilson, Caroline, additional, Alter, Sharon, additional, Huang, Yungyu, additional, Sublette, M. Elizabeth, additional, Goodman, Marianne, additional, Hazlett, Erin, additional, Yehuda, Rachel, additional, Arango, Victoria, additional, Rosoklija, Gorazd, additional, Dwork, Andrew, additional, Stanley, Barbara, additional, Ge, Yongchao, additional, Galfalvy, Hanga, additional, Mann, J. John, additional, and Haghighi, Fatemeh, additional

Published
2023
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33. Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective.

Author

Shengnan Sun, Wilson, Caroline M., Alter, Sharon, Yongchao Ge, Hazlett, Erin A., Goodman, Marianne, Yehuda, Rachel, Galfalvy, Hanga, and Haghighi, Fatemeh

Subjects
SUICIDAL ideation, SUICIDE risk factors, BLOOD plasma, ATTEMPTED suicide, INTERLEUKIN-6
Abstract

Introduction: Studies showing associations between inflammation in suicide are typically cross-sectional. Present study investigated how cytokine levels track with suicidal ideation and severity longitudinally. Methods: Veterans with a diagnosis of major depressive disorder (MDD) with or without suicide attempt history (MDD/SA n = 38, MDD/NS n = 41) and non-psychiatric non-attempter controls (HC n = 33) were recruited, MDD/SA and HC groups were followed longitudinally at 3 months and 6 months. Blood plasma was collected and processed using Luminex Immunology Multiplex technology. Results: Significant differences in depression severity (BDI) and suicidal ideation severity (SSI) were observed across all groups at study entry, wherein MDD/ SA group had the highest scores followed by MDD/NS and HC, respectively. Cytokines IL-1β, IL-4, TNF-α, IFN-γ, and IL-6 were examined at study entry and longitudinally, with IL6 levels differing significantly across the groups (p = 0.0123) at study entry. Significant differences in changes in cytokine levels between depressed attempters and the control group were detected for IL-6 (interaction F1,91.77= 5.58, p = 0.0203) and TNF-α (F1,101.73 = 4.69, p = 0.0327). However, only depressed attempters showed a significant change, in IL-6 and TNF-α levels, decreasing over time [IL-6: b = -0.04, 95% CI = (-0.08, -0.01), p = 0.0245 and TNF-α: b = -0.02, 95% CI = (-0.04, -0.01), p = 0.0196]. Although IL-6 levels were not predictive of suicidal ideation presence [OR = 1.34, 95% CI = (0.77, 2.33), p = 0.3067], IL-6 levels were significantly associated with suicidal ideation severity (b = 0.19, p = 0.0422). Discussion: IL-6 was not associated with presence of suicidal ideation. IL-6 however, was associated with severity of ideation, suggesting that IL-6 may be useful in clinical practice, as an objective marker of heightened suicide risk. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Improving the prospective prediction of a near-term suicide attempt in veterans at risk for suicide, using a go/no-go task.

Author

Myers, Catherine E., Dave, Chintan V., Callahan, Michael, Chesin, Megan S., Keilp, John G., Beck, Kevin D., Brenner, Lisa A., Goodman, Marianne S., Hazlett, Erin A., Niculescu, Alexander B., St. Hill, Lauren, Kline, Anna, Stanley, Barbara H., and Interian, Alejandro

Subjects
SUICIDE risk factors, COMPUTER simulation, CONFIDENCE intervals, IMPULSIVE personality, TIME, TASK performance, HEALTH outcome assessment, RISK assessment, SUICIDAL behavior, PSYCHOLOGY of veterans, NEUROPSYCHOLOGICAL tests, MATHEMATICAL variables, DESCRIPTIVE statistics, RESEARCH funding, SOCIODEMOGRAPHIC factors, ODDS ratio, SECONDARY analysis
Abstract

Background: Neurocognitive testing may advance the goal of predicting near-term suicide risk. The current study examined whether performance on a Go/No-go (GNG) task, and computational modeling to extract latent cognitive variables, could enhance prediction of suicide attempts within next 90 days, among individuals at high-risk for suicide. Method: 136 Veterans at high-risk for suicide previously completed a computer-based GNG task requiring rapid responding (Go) to target stimuli, while withholding responses (No-go) to infrequent foil stimuli; behavioral variables included false alarms to foils (failure to inhibit) and missed responses to targets. We conducted a secondary analysis of these data, with outcomes defined as actual suicide attempt (ASA), other suicide-related event (OtherSE) such as interrupted/aborted attempt or preparatory behavior, or neither (noSE), within 90-days after GNG testing, to examine whether GNG variables could improve ASA prediction over standard clinical variables. A computational model (linear ballistic accumulator, LBA) was also applied, to elucidate cognitive mechanisms underlying group differences. Results: On GNG, increased miss rate selectively predicted ASA, while increased false alarm rate predicted OtherSE (without ASA) within the 90-day follow-up window. In LBA modeling, ASA (but not OtherSE) was associated with decreases in decisional efficiency to targets, suggesting differences in the evidence accumulation process were specifically associated with upcoming ASA. Conclusions: These findings suggest that GNG may improve prediction of near-term suicide risk, with distinct behavioral patterns in those who will attempt suicide within the next 90 days. Computational modeling suggests qualitative differences in cognition in individuals at near-term risk of suicide attempt. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Improving the prospective prediction of a near-term suicide attempt in veterans at risk for suicide, using a go/no-go task

Author

Myers, Catherine E., primary, Dave, Chintan V., additional, Callahan, Michael, additional, Chesin, Megan S., additional, Keilp, John G., additional, Beck, Kevin D., additional, Brenner, Lisa A., additional, Goodman, Marianne S., additional, Hazlett, Erin A., additional, Niculescu, Alexander B., additional, St. Hill, Lauren, additional, Kline, Anna, additional, Stanley, Barbara H., additional, and Interian, Alejandro, additional

Published
2022
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45. P400. Longitudinal Changes in Attention and Memory in Pregnant and Postpartum Women

Author

Kakalis, Matina, primary, Smith, Emma, additional, Samonek, Katherine, additional, Rajasekaran, Vignesh, additional, Jamieson, Lindsay, additional, Kuczarski, Kellyn, additional, De Witte, Lotje, additional, Katz, Dan, additional, Dolan, Siobhan M., additional, McMeen, Kelly, additional, Koenigsberg, Harold, additional, Hazlett, Erin, additional, New, Antonia, additional, Pietrzak, Robert, additional, McClure, Margaret, additional, and Perez-Rodriguez, M. Mercedes, additional

Published
2022
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46. P408. An Exploration of Social Cognition in Pregnancy and Postpartum

Author

Smith, Emma, primary, Delaney, Ashlyn, additional, Ogundipe, Tonia, additional, Kuczarski, Kellyn, additional, Leila, Amaliya, additional, Saxenian, Sylvia, additional, Li, Deborah, additional, Rahman, Revana, additional, New, Antonia S., additional, Hazlett, Erin A., additional, Koenigsberg, Harold W., additional, Spicer, Julie, additional, Pietrzak, Robert, additional, Bergink, Veerle, additional, Dolan, Siobhan M., additional, McClure, Margaret, additional, De Witte, Lotje, additional, and Perez-Rodriguez, M. Mercedes, additional

Published
2022
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