1. One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P®/Humate P® treatment in von Willebrand disease patients
- Author
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de Jager, N.C.B. (Nico C. B.), Bukkems, L.H. (Laura H.), Heijdra, J.M. (Jessica), Hazendonk, C.H.C.A.M. (Carolien H. C. A. M.), Fijnvandraat, K., Meijer, K. (Karina), Eikenboom, J.C.J. (Jeroen), Laros-Van Gorkom, B.A.P. (Britta), Leebeek, F.W.G. (Frank), Cnossen, M.H. (Marjon), Mathot, R.A. (Ron), Collins, P.W., Kruip, M.J.H.A. (Marieke), Polinder, S. (Suzanne), Lock, J. (J.), Moort, I. (Iris) van, Goedhart, M.C.H.J. (M. C.H.J.), Coppens, M., Peters, M.A.D. (Marjolein), Preijers, T., Brons, P.P., Meer, F.J.M. (Felix) van der, Schutgens, R. (Roger), Fischer, K. (Kathelijn), Driessens, M.H.E. (M. H.E.), Zwaan, C.M. (Michel), van Vliet, I. (I.), Liesner, R. (Ri), Chowdary, P. (P.), Keeling, D. (D.), de Jager, N.C.B. (Nico C. B.), Bukkems, L.H. (Laura H.), Heijdra, J.M. (Jessica), Hazendonk, C.H.C.A.M. (Carolien H. C. A. M.), Fijnvandraat, K., Meijer, K. (Karina), Eikenboom, J.C.J. (Jeroen), Laros-Van Gorkom, B.A.P. (Britta), Leebeek, F.W.G. (Frank), Cnossen, M.H. (Marjon), Mathot, R.A. (Ron), Collins, P.W., Kruip, M.J.H.A. (Marieke), Polinder, S. (Suzanne), Lock, J. (J.), Moort, I. (Iris) van, Goedhart, M.C.H.J. (M. C.H.J.), Coppens, M., Peters, M.A.D. (Marjolein), Preijers, T., Brons, P.P., Meer, F.J.M. (Felix) van der, Schutgens, R. (Roger), Fischer, K. (Kathelijn), Driessens, M.H.E. (M. H.E.), Zwaan, C.M. (Michel), van Vliet, I. (I.), Liesner, R. (Ri), Chowdary, P. (P.), and Keeling, D. (D.)
- Abstract
Introduction: Many patients with von Willebrand disease (VWD) are treated on demand with von Willebrand factor and factor VIII (FVIII) containing concentrates present with VWF and/or FVIII plasma levels outside set target levels. This carries a risk for bleeding and potentially for thrombosis. Development of a population pharmacokinetic (PK) model based on FVIII levels is a first step to more accurate on-demand perioperative dosing of this concentrate.
- Published
- 2019
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