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22,464 results on '"Hazen A"'

1. Design, Construction, and Testing of the APOLLO ATCA Blades for Use at the HL-LHC

Author: Akpinar, A., Blaizot, A., Cholak, S., de Castro, G., Demiragli, Z., Duquette, A., Fulcher, J., Gastler, D., Hahn, K., Hazen, E., Kotamnives, P., Madorsky, A., Monk, D., Noorudhin, S., Oshiro, M., Rohlf, J., Strohman, C., Tsai, E., Wittich, P., Yuan, S., and Zou, R.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The Apollo Advanced Telecommunications Computing Architecture (ATCA) platform is an open-source design consisting of a generic "Service Module" (SM) and a customizable "Command Module" (CM), allowing for cost-effective use in applications such as the readout of the inner tracker and the Level-1 track trigger for the CMS Phase-II upgrade at the HL-LHC. The SM integrates an intelligent IPMC, robust power entry and conditioning systems, a powerful system-on-module computer, and flexible clock and communication infrastructure. The CM is designed around two Xilinx Ultrascale+ FPGAs and high-density, high-bandwidth optical transceivers capable of 25 Gb/s. Crates of Apollo blades are currently being tested at Boston University, Cornell University, and CERN., Comment: 7 pages, 4 figures, TWEPP2024 conference proceedings
Published: 2025

2. Pengaruh Baby Massage Terhadap Durasi Menyusui Pada Bayi Usia 3-30 Hari Di Puskesmas Bulang Kota Batam

Author: Hazen Aziz and Siti Husaidah
Subjects: pijat bayi, durasi menyusui, Medicine (General), R5-920
Abstract: Pendahuluan: Durasi menyusui tertinggi banyak terjadi di usia bayi 1-6 jam setelah lahir dengan persentase 35,2% dan kurang dari 1 jam setelah lahir dengan persentase 34,5% sedangkan durasi menyusui terendah banyak terjadi di usia 7-23 jam setelah lahir dan bahkan berlanjut hingga 3 hari sebesar 3,7%, durasi menyusui kurang erat kaitannya dengan gizi kurang. Penelitian ini bertujuan untuk mengetahui pengaruh baby massage terhadap durasi menyusu pada bayi usia 3-30 hari di Puskesmas Bulang Kota Batam Tahun 2020. Metode: Metode penelitian yang digunakan adalah quasy eksperiment dan khohort prospektif dengan menggunakan pre-post tes control design. Subyek penelitian sebanyak 50 responden yang terdiri dari 25 kelompok eksperimen dengan dilakukan baby massage dan 25 kelompok kontrol yang diberi penyuluhan terkait pentingnya menyusui. Penelitian ini dilakukan selama 27 hari dengan dua kali pengukuran yakni usia 3 hari (Pre test) dan usia 30 hari (Post test). Analisis data menggunakan Uji T test. Hasil: Hasil penelitian pada kelompok kontrol terdapat rata-rata durasi menyusu di usia 3 hari adalah 5,44 menit dan durasi menyusu di usia 30 hari adalah 5,52 menit, berdasarkan hasil uji t p= 0,802 > 0,05 artinya tidak terdapat pengaruh pada kelompok kontrol. Nilai rata-rata durasi menyusu pada kelompok eksperimen pada usia 30 hari adalah 5,40 menit dan durasi menyusu di usia 30 hari adalah 7,36 menit, hasil uji t diperoleh p= 0,00 < 0,05 artinya secara statistik menunjukkan terdapat pengaruh peningkatan durasi menyusu pada kelompok eksperimen. Kesimpulan: Ada pengaruh baby massage terhadap peningkatan durasi menyusu bayi usia 3-30 hari, dengan nilai p
Published: 2021
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3. Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models.

Author: Biswas, Subarna, Hilser, James, Woodward, Nicholas, Wang, Zeneng, Gukasyan, Janet, Nemet, Ina, Schwartzman, William, Huang, Pin, Han, Yi, Fouladian, Zachary, Charugundla, Sarada, Spencer, Neal, Pan, Calvin, Tang, W, Lusis, Aldons, Hazen, Stanley, Hartiala, Jaana, and Allayee, Hooman
Subjects: Mendelian randomization, atherosclerosis, coronary artery disease, dietary supplementation, genome-wide association study, glycine, mice, Glycine, Animals, Humans, Coronary Artery Disease, Genome-Wide Association Study, Mice, Male, Female, Middle Aged, Disease Models, Animal, Mendelian Randomization Analysis, Aged, Atherosclerosis, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Dietary Supplements, United Kingdom
Abstract: Background: Circulating glycine levels have been associated with reduced risk of coronary artery disease (CAD) in humans but these associations have not been observed in all studies. We evaluated whether the relationship between glycine levels and atherosclerosis was causal using genetic analyses in humans and feeding studies in mice. Methods: Serum glycine levels were evaluated for association with risk of CAD in the UK Biobank. Genetic determinants of glycine levels were identified through a genome-wide association study (GWAS) and used to evaluate the causal relationship between glycine and risk of CAD by Mendelian randomization (MR). A dietary supplementation study was carried out with atherosclerosis-prone apolipoprotein E deficient (ApoE-/-) mice to determine the effects of increased circulating glycine levels on cardiometabolic traits and aortic lesion formation. Results: Among 105,718 UK Biobank subjects, elevated serum glycine levels were associated with significantly reduced risk of prevalent CAD (Quintile 5 vs. Quintile 1 OR = 0.76, 95% CI 0.67-0.87; p < 0.0001) and incident CAD (Quintile 5 vs. Quintile 1 HR = 0.70, 95% CI 0.65-0.77; p < 0.0001) after adjustment for age, sex, ethnicity, anti-hypertensive and lipid-lowering medications, blood pressure, kidney function, and diabetes. A GWAS meta-analysis with 230,947 subjects identified 61 loci for glycine levels, of which 26 were novel. MR analyses provided modest evidence that genetically elevated glycine levels were causally associated with reduced systolic blood pressure and risk of type 2 diabetes, but did not provide significant evidence for an association with decreased risk of CAD. Glycine supplementation in mice had no effects on cardiometabolic traits or atherosclerotic lesion development. Conclusions: While expanding the genetic architecture of glycine metabolism, MR analyses and in vivo feeding studies did not provide evidence that the clinical association of this amino acid with atherosclerosis represents a causal relationship.
Published: 2025

4. The track-length extension fitting algorithm for energy measurement of interacting particles in liquid argon TPCs and its performance with ProtoDUNE-SP data

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Alex, N. S., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Choi, G., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farrell, S., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferry, G., Fialova, E., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gaba, R., Gabrielli, A., Gago, A. M., Galizzi, F., Gallagher, H., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Gazzana, S., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, L., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, F. Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hadavand, H., Haegel, L., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hakenmüller, J., Hamernik, T., Hamilton, P., Hancock, J., Happacher, F., Harris, D. A., Hart, A. L., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C. M., Hatcher, R., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Hellmuth, P., Henry, S., Herner, K., Hewes, V., Higuera, A., Hilgenberg, C., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horiuchi, S., Horton-Smith, G. A., Houdy, T., Howard, B., Howell, R., Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Ibrahim, M., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jena, D., Jentz, I., Ji, X., Jiang, C., Jiang, J., Jiang, L., Jipa, A., Jo, J. H., Joaquim, F. R., Johnson, W., Jollet, C., Jones, B., Jones, R., Jovancevic, N., Judah, M., Jung, C. K., Jung, K. Y., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A. C., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kandemir, M., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kauther, A., Kazaryan, N., Ke, L., Kearns, E., Keener, P. T., Kelly, K. J., Kemp, E., Kemularia, O., Kermaidic, Y., Ketchum, W., Kettell, S. H., Khabibullin, M., Khan, N., Khvedelidze, A., Kim, D., Kim, J., Kim, M. J., King, B., Kirby, B., Kirby, M., Kish, A., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koch, L., Koehler, K., Koerner, L. W., Koh, D. H., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kovalcuk, M., Kozhukalov, V., Krah, W., Kralik, R., Kramer, M., Kreczko, L., Krennrich, F., Kreslo, I., Kroupova, T., Kubota, S., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kufatty, G., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kumaran, S., Kunzmann, J., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Labree, T., Lackey, T., Lalău, I., Lambert, A., Land, B. J., Lane, C. E., Lane, N., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laudrain, A., Laundrie, A., Laurenti, G., Lavaut, E., Laycock, P., Lazanu, I., LaZur, R., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeCompte, T., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Silverio, D. Leon, Lepin, L. M., Li, J. -Y, Li, S. W., Li, Y., Liao, H., Lin, C. S., Lindebaum, D., Linden, S., Lineros, R. A., Lister, A., Littlejohn, B. R., Liu, H., Liu, J., Liu, Y., Lockwitz, S., Lokajicek, M., Lomidze, I., Long, K., Lopes, T. V., Lopez, J., de Rego, I. López, López-March, N., Lord, T., LoSecco, J. M., Louis, W. C., Sanchez, A. Lozano, Lu, X. -G., Luk, K. B., Lunday, B., Luo, X., Luppi, E., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., MacMahon, M., Maddalena, A., Madera, A., Madigan, P., Magill, S., Magueur, C., Mahn, K., Maio, A., Major, A., Majumdar, K., Mameli, S., Man, M., Mandujano, R. C., Maneira, J., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Corchado, S. Manthey, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marques, F. Das Chagas, Marquet, C., Marshak, M., Marshall, C. M., Marshall, J., Martina, L., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Massari, C., Mastbaum, A., Matichard, F., Matsuno, S., Matteucci, G., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., McAskill, T., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Meazza, L., Meddage, V. C. N., Mefodiev, A., Mehta, B., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Mercuri, A. C. E. A., Meregaglia, A., Messier, M. D., Metallo, S., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Micallef, J., Miccoli, A., Michna, G., Milincic, R., Miller, F., Miller, G., Miller, W., Mineev, O., Minotti, A., Miralles, L., Mironov, C., Miryala, S., Miscetti, S., Mishra, C. S., Mishra, P., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Mooney, M., Moor, A. F., Moore, Z., Moreno, D., Moreno-Palacios, O., Morescalchi, L., Moretti, D., Moretti, R., Morris, C., Mossey, C., Moura, C. A., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mukhamejanov, Y., Mulhearn, M., Munford, D., Munteanu, L. J., Muramatsu, H., Muraz, J., Murphy, M., Murphy, T., Muse, J., Mytilinaki, A., Nachtman, J., Nagai, Y., Nagu, S., Nandakumar, R., Naples, D., Narita, S., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nehm, A., Nelson, J. K., Neogi, O., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, A., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Oh, S., Oh, S. B., Olivier, A., Olshevskiy, A., Olson, T., Onel, Y., Onishchuk, Y., Oranday, A., Osbiston, M., Vélez, J. A. Osorio, O'Sullivan, L., Ormachea, L. Otiniano, Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Panda, P., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papaleo, R., Papanestis, A., Papoulias, D., Paramesvaran, S., Paris, A., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Patrick, C., Patrizii, L., Patterson, R. B., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Pedreschi, E., Peeters, S. J. M., Pellico, W., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Gonzalez, Y. F. Perez, Pérez-Molina, L., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pfaff, M., Pia, V., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Pincha, S., Pinchault, J., Pitts, K., Plows, K., Pollack, C., Pollman, T., Pompa, F., Pons, X., Poonthottathil, N., Popov, V., Poppi, F., Porter, J., Paixão, L. G. Porto, Potekhin, M., Potenza, R., Pozzato, M., Prakash, T., Pratt, C., Prest, M., Psihas, F., Pugnere, D., Qian, X., Queen, J., Raaf, J. L., Radeka, V., Rademacker, J., Radics, B., Raffaelli, F., Rafique, A., Raguzin, E., Rahaman, U., Rai, M., Rajagopalan, S., Rajaoalisoa, M., Rakhno, I., Rakotondravohitra, L., Ralte, L., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ray, R., Razafinime, H., Razakamiandra, R. F., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renner, E., Renshaw, A., Rescia, S., Resnati, F., Restrepo, Diego, Reynolds, C., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Ricol, J. S., Rigan, M., Rincón, E. V., Ritchie-Yates, A., Ritter, S., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Rosauro-Alcaraz, S., Rosier, P., Ross, D., Rossella, M., Rossi, M., Ross-Lonergan, M., Roy, N., Roy, P., Rubbia, C., Ruggeri, A., Ferreira, G. Ruiz, Russell, B., Ruterbories, D., Rybnikov, A., Sacerdoti, S., Saha, S., Sahoo, S. 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Tapia, Tapper, A., Tariq, S., Tarpara, E., Tatar, E., Tayloe, R., Tedeschi, D., Teklu, A. M., Vidal, J. Tena, Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thomas, S., Thompson, A., Thorn, C., Timm, S. C., Tiras, E., Tishchenko, V., Tiwari, S., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Tran, D., Travaglini, R., Trevor, J., Triller, E., Trilov, S., Truchon, J., Truncali, D., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tu, S. Z., Tufanli, S., Tunnell, C., Turnberg, S., Turner, J., Tuzi, M., Tyler, J., Tyley, E., Tzanov, M., Uchida, M. A., González, J. Ureña, Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Van Berg, R., Van de Water, R. G., Forero, D. 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J., Winter, P., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, J., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zapata, O., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy loss as a function of the energy, including models of electron recombination and detector response. The algorithm can be used to measure the energies of particles that interact before they stop, such as charged pions that are absorbed by argon nuclei. The algorithm's energy measurement resolutions and fractional biases are presented as functions of particle kinetic energy and number of track hits using samples of stopping secondary charged pions in data collected by the ProtoDUNE-SP detector, and also in a detailed simulation. Additional studies describe the impact of the dE/dx model on energy measurement performance. The method described in this paper to characterize the energy measurement performance can be repeated in any LArTPC experiment using stopping secondary charged pions.
Published: 2024

5. Key Considerations in Developing a School Leadership Program

Author: Hazen Barrett
Abstract: School systems throughout the world are struggling with the issue of who will lead public schools today, and in the future. The patriarchal model from the past, when authority was not to be questioned and educational leadership was viewed in a straightforward, one-dimensional perspective, has been replaced by a complicated combination of expectations and pressures. This article outlines preparation and training factors that should be considered by school boards in selecting leadership candidates, and when designing training models for school leadership. Understanding the frustrations and contradictions that exist in the modern school environment makes survival in school leadership a matter of political aptitude, and a function of technical skill. The requirement becomes a search for individuals who can guide their schools in response to local needs while meeting non-local mandates.
Published: 2024

6. COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type.

Author: Hilser, James R, Spencer, Neal J, Afshari, Kimia, Gilliland, Frank D, Hu, Howard, Deb, Arjun, Lusis, Aldons J, Wilson Tang, WH, Hartiala, Jaana A, Hazen, Stanley L, and Allayee, Hooman
Subjects: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Coronaviruses, Atherosclerosis, Emerging Infectious Diseases, Cardiovascular, Heart Disease, Infectious Diseases, Heart Disease - Coronary Heart Disease, Genetics, 2.1 Biological and endogenous factors, Good Health and Well Being, COVID-19, SARS-CoV-2, genetics, major adverse cardiac events, myocardial infarction, stroke, thrombosis, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract: BackgroundCOVID-19 is associated with acute risk of major adverse cardiac events (MACE), including myocardial infarction, stroke, and mortality (all-cause). However, the duration and underlying determinants of heightened risk of cardiovascular disease and MACE post-COVID-19 are not known.MethodsData from the UK Biobank was used to identify COVID-19 cases (n=10 005) who were positive for polymerase chain reaction (PCR+)-based tests for SARS-CoV-2 infection (n=8062) or received hospital-based International Classification of Diseases version-10 (ICD-10) codes for COVID-19 (n=1943) between February 1, 2020 and December 31, 2020. Population controls (n=217 730) and propensity score-matched controls (n=38 860) were also drawn from the UK Biobank during the same period. Proportional hazard models were used to evaluate COVID-19 for association with long-term (>1000 days) risk of MACE and as a coronary artery disease risk equivalent. Additional analyses examined whether COVID-19 interacted with genetic determinants to affect the risk of MACE and its components.ResultsThe risk of MACE was elevated in COVID-19 cases at all levels of severity (HR, 2.09 [95% CI, 1.94-2.25]; P
Published: 2024

7. DUNE Phase II: Scientific Opportunities, Detector Concepts, Technological Solutions

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D. M., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Barham~Alzás, P., Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chakraborty, S., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cortez, A. F. V., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farrell, S., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Fernández-Posada, D., Ferry, G., Fialova, E., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gaba, R., Gabrielli, A., M~Gago, A., Galizzi, F., Gallagher, H., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Gazzana, S., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, L., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, F. Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hadavand, H., Haegel, L., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hakenmüller, J., Hamernik, T., Hamilton, P., Hancock, J., Happacher, F., Harris, D. A., Hart, A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C. M., Hatcher, R., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Hellmuth, P., Henry, S., Hernández-García, J., Herner, K., Hewes, V., Higuera, A., Hilgenberg, C., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horiuchi, S., Horton-Smith, G. A., Houdy, T., Howard, B., Howell, R., Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Ibrahim, M., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. 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A., Kothekar, K., Kotler, I., Kovalcuk, M., Kozhukalov, V., Krah, W., Kralik, R., Kramer, M., Kreczko, L., Krennrich, F., Kreslo, I., Kroupova, T., Kubota, S., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kufatty, G., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kumaran, S., Kunzmann, J., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kuźniak, M., Kvasnicka, J., Labree, T., Lackey, T., Lalău, I., Lambert, A., Land, B. J., Lane, C. E., Lane, N., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laudrain, A., Laundrie, A., Laurenti, G., Lavaut, E., Laycock, P., Lazanu, I., LaZur, R., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeCompte, T., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Silverio, D. Leon, Lepin, L. M., -Y~Li, J., Li, S. W., Li, Y., Liao, H., Lin, C. S., Lindebaum, D., Linden, S., Lineros, R. A., Lister, A., Littlejohn, B. 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Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the European Strategy for Particle Physics. While the construction of the DUNE Phase I is well underway, this White Paper focuses on DUNE Phase II planning. DUNE Phase-II consists of a third and fourth far detector (FD) module, an upgraded near detector complex, and an enhanced 2.1 MW beam. The fourth FD module is conceived as a "Module of Opportunity", aimed at expanding the physics opportunities, in addition to supporting the core DUNE science program, with more advanced technologies. This document highlights the increased science opportunities offered by the DUNE Phase II near and far detectors, including long-baseline neutrino oscillation physics, neutrino astrophysics, and physics beyond the standard model. It describes the DUNE Phase II near and far detector technologies and detector design concepts that are currently under consideration. A summary of key R&D goals and prototyping phases needed to realize the Phase II detector technical designs is also provided. DUNE's Phase II detectors, along with the increased beam power, will complete the full scope of DUNE, enabling a multi-decadal program of groundbreaking science with neutrinos.
Published: 2024

8. The doctor will polygraph you now: ethical concerns with AI for fact-checking patients

Author: Anibal, James, Gunkel, Jasmine, Awan, Shaheen, Huth, Hannah, Nguyen, Hang, Le, Tram, Bélisle-Pipon, Jean-Christophe, Boyer, Micah, Hazen, Lindsey, Consortium, Bridge2AI Voice, Bensoussan, Yael, Clifton, David, and Wood, Bradford
Subjects: Computer Science - Computers and Society
Abstract: Artificial intelligence (AI) methods have been proposed for the prediction of social behaviors which could be reasonably understood from patient-reported information. This raises novel ethical concerns about respect, privacy, and control over patient data. Ethical concerns surrounding clinical AI systems for social behavior verification can be divided into two main categories: (1) the potential for inaccuracies/biases within such systems, and (2) the impact on trust in patient-provider relationships with the introduction of automated AI systems for fact-checking, particularly in cases where the data/models may contradict the patient. Additionally, this report simulated the misuse of a verification system using patient voice samples and identified a potential LLM bias against patient-reported information in favor of multi-dimensional data and the outputs of other AI methods (i.e., AI self-trust). Finally, recommendations were presented for mitigating the risk that AI verification methods will cause harm to patients or undermine the purpose of the healthcare system., Comment: 17 pages, 3 figures, 4 tables
Published: 2024

9. First Measurement of the Total Inelastic Cross-Section of Positively-Charged Kaons on Argon at Energies Between 5.0 and 7.5 GeV

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Barham~Alzás, P., Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chakraborty, S., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. 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Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each beam momentum setting was measured to be 380$\pm$26 mbarns for the 6 GeV/$c$ setting and 379$\pm$35 mbarns for the 7 GeV/$c$ setting.
Published: 2024
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10. Supernova Pointing Capabilities of DUNE

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. 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Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: The determination of the direction of a stellar core collapse via its neutrino emission is crucial for the identification of the progenitor for a multimessenger follow-up. A highly effective method of reconstructing supernova directions within the Deep Underground Neutrino Experiment (DUNE) is introduced. The supernova neutrino pointing resolution is studied by simulating and reconstructing electron-neutrino charged-current absorption on $^{40}$Ar and elastic scattering of neutrinos on electrons. Procedures to reconstruct individual interactions, including a newly developed technique called ``brems flipping'', as well as the burst direction from an ensemble of interactions are described. Performance of the burst direction reconstruction is evaluated for supernovae happening at a distance of 10 kpc for a specific supernova burst flux model. The pointing resolution is found to be 3.4 degrees at 68% coverage for a perfect interaction-channel classification and a fiducial mass of 40 kton, and 6.6 degrees for a 10 kton fiducial mass respectively. Assuming a 4% rate of charged-current interactions being misidentified as elastic scattering, DUNE's burst pointing resolution is found to be 4.3 degrees (8.7 degrees) at 68% coverage., Comment: 25 pages, 16 figures
Published: 2024

11. Interdecadal variability of streamflow in the Hudson Bay Lowlands watersheds driven by atmospheric circulation

Author: Olivier Champagne, M. Altaf Arain, Shusen Wang, Martin Leduc, and Hazen A.J. Russell
Subjects: Hudson Bay Lowlands, Subarctic region, MESH, Streamflow, ERA5, Atmospheric circulation, Physical geography, GB3-5030, Geology, QE1-996.5
Abstract: Study region: Hudson Bay Lowlands watersheds, Ontario, Canada. Study Focus: The rivers in the Hudson Bay Lowlands are a major source of freshwater entering the Arctic Ocean and they also cause major floods. In recent decades, this region has been affected by major changes in hydroclimatic processes attributed to climate change and natural climate variability. In this study, we used ERA5 reanalysis data, hydrometric observations, and the hydrological model MESH, to investigate the impact of atmospheric circulation on the inter-decadal variability of streamflow between 1979 and 2018 in the Hudson Bay Lowlands. The natural climate variability was assessed using a weather regimes approach based on the discretization of daily geopotential height anomalies (Z500) from ERA5 reanalysis, as well as large scale oceanic and atmospheric variability modes. New hydrological insights: The results showed an anomalous convergence of atmospheric moisture flux between 1995–2008 that enhanced precipitation and increased streamflow in the western part of the region. This moisture convergence was likely driven by the combination of (i) low pressure anomalies in the East Coast of North America and (ii) low pressure anomalies in western regions of Canada, associated with the cold phase of the pacific decadal oscillation (PDO). Since 2009, streamflow remains high, likely due to more groundwater discharge associated with the degradation of permafrost.
Published: 2021
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12. Comparative mechanisms of Cr(VI) adsorption on biosynthetically derived Iron-minerals

Author: Hazen, Terry C.
Published: 2025
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13. Smart goggles augmented reality CT–US fusion compared to conventional fusion navigation for percutaneous needle insertion

Author: Borde, Tabea, Saccenti, Laetitia, Li, Ming, Varble, Nicole A., Hazen, Lindsey A., Kassin, Michael T., Ukeh, Ifechi N., Horton, Keith M., Delgado, Jose F., Martin, 3rd, Charles, Xu, Sheng, Pritchard, William F., Karanian, John W., and Wood, Bradford J.
Published: 2025
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14. Quantifying morphologic variations as an alternate to standard response criteria for unresectable primary liver tumors after checkpoint inhibition therapy

Author: Saccenti, Laetitia, Varble, Nicole, Borde, Tabea, Mikhail, Andrew S., Kassin, Michael, Levy, Elliot, Xu, Sheng, Hazen, Lindsey A., Ukeh, Ifechi, Vasco, Cyndi, Duffy, Austin G., Xie, Changqing, Monge, Cecilia, Mabry, Donna, Greten, Tim F., and Wood, Bradford J.
Published: 2024
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15. Pharmacists’ perspectives on potential pharmacist prescribing: a nationwide survey in the Netherlands

Author: Kaymakci, Bilge, Philbert, Daphne, Hazen, Ankie C. M., Heringa, Mette, Kwint, Henk-Frans, Zwart, Dorien L. M., van Dijk, Liset, Kälvemark Sporrong, Sofia, and Kempen, Thomas G. H.
Published: 2024
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16. Multi-month forecasts of marine heatwaves and ocean acidification extremes

Author: Mogen, Samuel C., Lovenduski, Nicole S., Yeager, Stephen G., Capotondi, Antonietta, Jacox, Michael G., Bograd, Stephen, Di Lorenzo, Emanuele, Hazen, Elliot L., Pozo Buil, Mercedes, Kim, Who, and Rosenbloom, Nan
Published: 2024
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17. Glacial dispersal trains in North America

Author: Don I. Cummings and Hazen A. J. Russell
Subjects: Till dispersal trains, boulder trains, sediment provenance, mineral exploration, drift prosecting, Laurentide ice sheet, Maps, G3180-9980
Abstract: A map depicting glacial dispersal trains in North America has been compiled from published sources. It covers the Canadian Shield, the Arctic Islands, the Cordillera and Appalachian mountains, and Phanerozoic sedimentary basins south of the Shield. In total, 140 trains are portrayed, including those emanating from major mineral-deposit types (e.g. gold, base metal, diamondiferous kimberlite, etc.). The map took 10 years of on-and-off work to generate, and it culls data from over 150 years of work by government, industry, and academia. It provides a new tool to help companies find ore deposits in Canada: the trains are generally a better predictor of dispersal distance and direction than striations and streamlined landforms, the data typically depicted on surficial-geology maps, including the Glacial Map of Canada. It also gives new insight into sedimentation patterns and processes beneath ice sheets, a sedimentary environment that, because of its inaccessibility, remains poorly understood and controversial.
Published: 2018
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18. Child, Adolescent, and Adult Development

Author: Morelli, Leah W., primary, Rubin, David H., additional, and Hazen, Eric P., additional
Published: 2025
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19. Contributors

Author: Acampora, Gregory Alexander, primary, Ahmad, Zeba N., additional, Alpay, Menekse, additional, Alpert, Jonathan E., additional, Babadi, Baktash, additional, Baek, Ji Hyun, additional, Baig, Mizra, additional, Bains, Ashika, additional, Baker, Amanda Waters, additional, Baldi, Olivia, additional, Beach, Scott R., additional, Beck, BJ, additional, Beckwith, Noor, additional, Benedek, David M., additional, Beresin, Eugene V., additional, Biederman, Joseph, additional, Bird, Suzanne A., additional, Blais, Mark A., additional, Bosson, Rahel, additional, Brendel, Rebecca Weintraub, additional, Bui, Eric, additional, Camprodon, Joan A., additional, Capawana, Michael R., additional, Caplan, Jason P., additional, Carter, Christopher, additional, Cassano, Paolo, additional, Cather, Corinne, additional, Celano, Christopher M., additional, Chang, Trina E., additional, Charoenpong, Prangthip, additional, Chemali, Zeina N., additional, Chen, Justin, additional, Chopra, Amit, additional, Choukas, Nathaniel, additional, Chung, Sun Young, additional, Cohen, Jonah, additional, Cohen, Lee S., additional, Colvin, Mary K. (Molly), additional, Conteh, Nkechi, additional, Crain, Laura D., additional, Cremens, M. Cornelia, additional, Cusin, Cristina, additional, Dekel, Sharon, additional, Denysenko, Lex, additional, Dickerson, Bradford C., additional, Donovan, Abigail L., additional, Doorley, James, additional, Dougherty, Darin D., additional, Ducharme, Simon, additional, Eddy, Kamryn T., additional, Edersheim, Judith G., additional, Evanoff, Anastasia B., additional, Fava, Maurizio, additional, Finn, Christine T., additional, Fernandez-Robles, Carlos, additional, Fishel, Anne K., additional, Forchelli, Gina, additional, Freudenreich, Oliver, additional, Fricchione, Gregory L., additional, Friedman, Nora D.B., additional, Gatchel, Jennifer R., additional, Gelaye, Bizu, additional, Georgiopoulos, Anna M., additional, Ghaznavi, Sharmin, additional, Ginsburg, Richard, additional, Gold, Alexandra K., additional, Gordon, Christopher D., additional, Gray, Caroline A., additional, Greenberg, Donna B., additional, Greer, Joseph, additional, Hazen, Eric P., additional, Henry, Michael E., additional, Herman, John B., additional, Himes, Susan, additional, Hogan, Charlotte, additional, Holt, Daphne J., additional, Huffman, Jeffery C., additional, Huguenel, Brynn, additional, Ipek, Simay, additional, Irwin, Kelly Edwards, additional, Ivkovic, Ana, additional, Jacobs, Jamie, additional, Jagodnik, Kathleen M., additional, Jain, Felipe A., additional, Jankauskaite, Greta, additional, Januzzi, James L., additional, Jenike, Michael A., additional, Jenkins, Jonathan, additional, Johnson, Justin M., additional, Julian, John N., additional, Kamali, Masoud, additional, Kaneko, Yoshio A., additional, Katz, Tamar C., additional, Keuroghlian, Alex, additional, Keuthen, Nancy J., additional, Khoshbin, Shahram, additional, Kim, Hyun-Hee, additional, Kim, Youngjung R., additional, Koh, Katherine A., additional, Kohrman, Samuel I., additional, Kontos, Nicholas, additional, Lagomasino, Isabel T., additional, Leval, Rebecca, additional, Leveroni, Catherine, additional, Lim, Carol, additional, Luccarelli, James, additional, Madarasmi, Saira, additional, Madva, Elizabeth N., additional, McCoy, Thomas H., additional, Milosavljevic, Nada, additional, Mischoulon, David, additional, Miyares, Peyton, additional, Morelli, Leah W., additional, Rodriguez, Alejandra E. Morfin, additional, Murray, Evan D., additional, Murray, Helen Burton, additional, Nejad, Shamim H., additional, Newhouse, Amy L., additional, Nicolson, Stephen E., additional, Nierenberg, Andrew A., additional, Nisavic, Mladen, additional, Nonacs, Ruta M., additional, Öngür, Dost, additional, Onyeaka, Henry, additional, Orr, Scott P., additional, Ostacher, Michael J., additional, Pace-Schott, Edward F., additional, Papakostas, George I., additional, Paudel, Shreedhar, additional, Peay, Celeste, additional, Pederson, Aderonke Bamgbose, additional, Penava, Susan J., additional, Perez, David L., additional, Perlis, Roy H., additional, Peters, Amy T., additional, Pinsky, Elizabeth G., additional, Pollak, Lauren Norton, additional, Pollastri, Alisha R., additional, Post, Loren M., additional, Powell, Alicia D., additional, Prager, Laura M., additional, Praschan, Nathan, additional, Price, Bruce H., additional, Prince, Jefferson B., additional, Probert, Julia M., additional, Prom, Maria C., additional, Punko, Diana, additional, Rauch, Scott L., additional, Raviola, Giuseppe J., additional, Reilly-Harrington, Noreen A., additional, Ritchie, Elspeth Cameron, additional, Rivas-Vazquez, Rafael, additional, Robinson, Ellen M., additional, Roffman, Joshua L., additional, Rubin, David H., additional, Ruchensky, Jared R., additional, Salvi, Joshua D., additional, Sanders, Kathy M., additional, Sanders, Wesley M., additional, Schlozman, Steven C., additional, Schouten, Ronald, additional, Schuster, Randi, additional, Shafer, Linda C., additional, Sheets, Jennifer, additional, Sher, Yelizaveta, additional, Sherman, Janet Cohen, additional, Sinclair, Samuel Justin, additional, Smith, Felicia A., additional, Sockalingam, Sanjeev, additional, Sogg, Stephanie, additional, Sorg, Emily M., additional, Sprich, Susan E., additional, Stein, Michelle B., additional, Stern, Theodore A., additional, Stoler, Joan M., additional, Stone, Mira, additional, Surman, Craig B.H., additional, Sylvia, Louisa G., additional, Tanev, Kaloyan S., additional, Tayeb, Haythum O., additional, Taylor, John B., additional, Thom, Robyn P., additional, Thomas, Jennifer J., additional, Tillman, Emma M., additional, Traeger, Lara, additional, Trinh, Nhi-Ha, additional, Uchida, Mai, additional, Ulman, Kathleen Hubbs, additional, Valera, Eve M., additional, Van Alphen, Manjola U., additional, Vazquez, Rafael, additional, Viguera, Adele C., additional, Wang, Betty, additional, Weilburg, Jeffrey B., additional, Weinberg, Marc, additional, Weinstein, Sylvie J., additional, Weisholtz, Daniel, additional, Wilens, Timothy E., additional, Wilhelm, Sabine, additional, Winkelman, John W., additional, Wright, Christopher L., additional, Wynn, Gary H., additional, Yeung, Albert, additional, Zakhary, Lisa, additional, and Zambrano, Juliana, additional
Published: 2025
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20. LiPost: Improved Content Understanding With Effective Use of Multi-task Contrastive Learning

Author: Bindal, Akanksha, Ramanujam, Sudarshan, Golland, Dave, Hazen, TJ, Jiang, Tina, Zhang, Fengyu, and Yan, Peng
Subjects: Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract: In enhancing LinkedIn core content recommendation models, a significant challenge lies in improving their semantic understanding capabilities. This paper addresses the problem by leveraging multi-task learning, a method that has shown promise in various domains. We fine-tune a pre-trained, transformer-based LLM using multi-task contrastive learning with data from a diverse set of semantic labeling tasks. We observe positive transfer, leading to superior performance across all tasks when compared to training independently on each. Our model outperforms the baseline on zero shot learning and offers improved multilingual support, highlighting its potential for broader application. The specialized content embeddings produced by our model outperform generalized embeddings offered by OpenAI on Linkedin dataset and tasks. This work provides a robust foundation for vertical teams across LinkedIn to customize and fine-tune the LLM to their specific applications. Our work offers insights and best practices for the field to build on.
Published: 2024

21. Voice EHR: Introducing Multimodal Audio Data for Health

Author: Anibal, James, Huth, Hannah, Li, Ming, Hazen, Lindsey, Daoud, Veronica, Ebedes, Dominique, Lam, Yen Minh, Nguyen, Hang, Hong, Phuc, Kleinman, Michael, Ost, Shelley, Jackson, Christopher, Sprabery, Laura, Elangovan, Cheran, Krishnaiah, Balaji, Akst, Lee, Lina, Ioan, Elyazar, Iqbal, Ekwati, Lenny, Jansen, Stefan, Nduwayezu, Richard, Garcia, Charisse, Plum, Jeffrey, Brenner, Jacqueline, Song, Miranda, Ricotta, Emily, Clifton, David, Thwaites, C. Louise, Bensoussan, Yael, and Wood, Bradford
Subjects: Computer Science - Sound, Computer Science - Artificial Intelligence, Computer Science - Computers and Society, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract: Artificial intelligence (AI) models trained on audio data may have the potential to rapidly perform clinical tasks, enhancing medical decision-making and potentially improving outcomes through early detection. Existing technologies depend on limited datasets collected with expensive recording equipment in high-income countries, which challenges deployment in resource-constrained, high-volume settings where audio data may have a profound impact on health equity. This report introduces a novel data type and a corresponding collection system that captures health data through guided questions using only a mobile/web application. The app facilitates the collection of an audio electronic health record (Voice EHR) which may contain complex biomarkers of health from conventional voice/respiratory features, speech patterns, and spoken language with semantic meaning and longitudinal context, potentially compensating for the typical limitations of unimodal clinical datasets. This report presents the application used for data collection, initial experiments on data quality, and case studies which demonstrate the potential of voice EHR to advance the scalability/diversity of audio AI., Comment: 21 pages, 5 figures, 6 tables
Published: 2024

22. Performance of a modular ton-scale pixel-readout liquid argon time projection chamber

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bracinik, J., Braga, D., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calin, M., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chakraborty, S., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farrell, S., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferry, G., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gaba, R., Gabrielli, A., Gago, A. M., Galizzi, F., Gallagher, H., Gallas, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Gazzana, S., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, L., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hadavand, H., Haegel, L., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hakenmueller, J., Hamernik, T., Hamilton, P., Hancock, J., Happacher, F., Harris, D. A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C., Hatcher, R., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hewes, V., Higuera, A., Hilgenberg, C., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horiuchi, S., Horton-Smith, G. A., Hostert, M., Houdy, T., Howard, B., Howell, R., Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Ibrahim, M., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jena, D., Jentz, I., Ji, X., Jiang, C., Jiang, J., Jiang, L., Jipa, A., Joaquim, F. R., Johnson, W., Jollet, C., Jones, B., Jones, R., Fernández, D. José, Jovancevic, N., Judah, M., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A. C., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kandemir, M., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kauther, A., Kazaryan, N., Ke, L., Kearns, E., Keener, P. T., Kelly, K. J., Kemp, E., Kemularia, O., Kermaidic, Y., Ketchum, W., Kettell, S. H., Khabibullin, M., Khan, N., Khotjantsev, A., Khvedelidze, A., Kim, D., Kim, J., King, B., Kirby, B., Kirby, M., Kish, A., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koch, L., Koehler, K., Koerner, L. W., Koh, D. H., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kovalcuk, M., Kozhukalov, V., Krah, W., Kralik, R., Kramer, M., Kreczko, L., Krennrich, F., Kreslo, I., Kroupova, T., Kubota, S., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kufatty, G., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kumaran, S., Kunze, P., Kunzmann, J., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Labree, T., Lackey, T., Lambert, A., Land, B. J., Lane, C. E., Lane, N., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laudrain, A., Laundrie, A., Laurenti, G., Lavaut, E., Lawrence, A., Laycock, P., Lazanu, I., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeCompte, T., Lee, C., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Silverio, D. Leon, Lepin, L. M., Li, J. -Y, Li, S. W., Li, Y., Liao, H., Lin, C. S., Lindebaum, D., Linden, S., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. 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O., Waters, D., Watson, A., Wawrowska, K., Weber, A., Weber, C. M., Weber, M., Wei, H., Weinstein, A., Wenzel, H., Westerdale, S., Wetstein, M., Whalen, K., Whilhelmi, J., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, A., Wilkinson, C., Wilson, F., Wilson, R. J., Winter, P., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zapata, O., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements, and provide comparisons to detector simulations., Comment: 47 pages, 41 figures
Published: 2024

23. Marine heatwaves redistribute pelagic fishing fleets

Author: Farchadi, Nima, Welch, Heather, Braun, Camrin D, Allyn, Andrew J, Bograd, Steven J, Brodie, Stephanie, Hazen, Elliott L, Kerney, Alex, Lezama‐Ochoa, Nerea, Mills, Katherine E, Pugh, Dylan, Young‐Morse, Riley, and Lewison, Rebecca L
Subjects: Environmental Sciences, Environmental Management, automatic information system, boosted regression trees, dynamic ocean management, marine heatwaves, pelagic fisheries, vessel distribution models, Ecology, Fisheries Sciences, Fisheries, Fisheries sciences, Environmental management
Abstract: Marine heatwaves (MHWs) have measurable impacts on marine ecosystems and reliant fisheries and associated communities. However, how MHWs translate to changes in fishing opportunities and the displacement of fishing fleets remains poorly understood. Using fishing vessel tracking data from the automatic identification system (AIS), we developed vessel distribution models for two pelagic fisheries targeting highly migratory species, the U.S. Atlantic longline and Pacific troll fleets, to understand how MHW properties (intensity, size, and duration) influence core fishing grounds and fleet displacement. For both fleets, MHW size had the largest influence on fishing ground area with northern fishing grounds gaining and southern fishing grounds decreasing in area. However, fleet displacement in response to MHWs varied between coasts, as the Atlantic longline fleet displaced farther in southern regions whereas the most northern and southern regions of the Pacific troll fleet shifted farther. Characterizing fishing fleet responses to these anomalous conditions can help identify regional vulnerabilities under future extreme events and aid in supporting climate-readiness and resilience in pelagic fisheries.
Published: 2024

24. Surface deformation observed by InSAR shows connections with water storage change in Southern Ontario

Author: Junhua Li, Shusen Wang, Cassandra Michel, and Hazen A.J. Russell
Subjects: Physical geography, GB3-5030, Geology, QE1-996.5
Abstract: Study region: A 10,000 km2 area of southwestern Ontario within the Lake Erie and Lake Ontario basins of the Laurentian Great Lakes basin, Ontario, Canada, a humid northern hydrogeological setting with abundant precipitation and recharge, and a stable Paleozoic sedimentary bedrock overlain by galacial sediment forming a relatively uncompressible sedimentary succession. Study focus: Examing land surface deformation in southern Ontario and its connection with water storage change. New hydrological insights: The surface deformation, observed from a set of 48 Radarsat-2 InSAR images over five years from Jan. 2013 to Sept. 2017 presents a subsidence trend of 1−10 mm/year and a seasonal variation of up to 20 mm over the region. The InSAR results are confirmed by the GPS measurements at six locations over the region. The surface deformations were compared to the water storage data derived from GRACE satellites, in-situ water levels of the Great Lakes, and precipitation data in the study area. The results indicate that the multi-year trend and seasonal variations in surface deformation are correlated to water storage changes, suggesting that the surface deformation in southern Ontario could be caused by water loading. Keywords: Surface deformation, Water storage, InSAR, Radarsat-2, GPS, GRACE
Published: 2020
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25. Interval Metastases After Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Esophageal Cancer: A Multicenter Observational Cohort Study

Author: van der Zijden, Charlène J., van der Sluis, Pieter C., Mostert, Bianca, Nuyttens, Joost J. M. E., van Lanschot, J. Jan B., Spaander, Manon C. W., Valkema, Roelf, Coene, Peter Paul L. O., Dekker, Jan Willem T., Fiets, Willem E., Hartgrink, Hendrik H., Hazen, Wouter L., Kouwenhoven, Ewout A., Nieuwenhuijzen, Grard A. P., Rosman, Camiel, van Sandick, Johanna W., Sosef, Meindert N., van der Zaag, Edwin S., Lagarde, Sjoerd M., and Wijnhoven, Bas P. L.
Published: 2024
Full Text: View/download PDF

26. Characteristics and preventability of medication-related admissions for acute kidney injury and dehydration in elderly patients

Author: Coppes, Tristan, Hazen, Ankie C. M., Zwart, Dorien L. M., Koster, Ellen S., van Gelder, Teun, and Bouvy, Marcel L.
Published: 2024
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27. Doping Liquid Argon with Xenon in ProtoDUNE Single-Phase: Effects on Scintillation Light

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Es-sghir, H. Amar, Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barenboim, G., BarhamAlzás, P., Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bracinik, J., Braga, D., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calin, M., Calivers, L., Calvo, E., Caminata, A., Campanelli, W., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clair, J., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collot, J., Conley, E., Conrad, J. M., Convery, M., Cooke, P., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., De la Torre, A., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. 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Subjects: Physics - Instrumentation and Detectors
Abstract: Doping of liquid argon TPCs (LArTPCs) with a small concentration of xenon is a technique for light-shifting and facilitates the detection of the liquid argon scintillation light. In this paper, we present the results of the first doping test ever performed in a kiloton-scale LArTPC. From February to May 2020, we carried out this special run in the single-phase DUNE Far Detector prototype (ProtoDUNE-SP) at CERN, featuring 720 t of total liquid argon mass with 410 t of fiducial mass. A 5.4 ppm nitrogen contamination was present during the xenon doping campaign. The goal of the run was to measure the light and charge response of the detector to the addition of xenon, up to a concentration of 18.8 ppm. The main purpose was to test the possibility for reduction of non-uniformities in light collection, caused by deployment of photon detectors only within the anode planes. Light collection was analysed as a function of the xenon concentration, by using the pre-existing photon detection system (PDS) of ProtoDUNE-SP and an additional smaller set-up installed specifically for this run. In this paper we first summarize our current understanding of the argon-xenon energy transfer process and the impact of the presence of nitrogen in argon with and without xenon dopant. We then describe the key elements of ProtoDUNE-SP and the injection method deployed. Two dedicated photon detectors were able to collect the light produced by xenon and the total light. The ratio of these components was measured to be about 0.65 as 18.8 ppm of xenon were injected. We performed studies of the collection efficiency as a function of the distance between tracks and light detectors, demonstrating enhanced uniformity of response for the anode-mounted PDS. We also show that xenon doping can substantially recover light losses due to contamination of the liquid argon by nitrogen., Comment: 36 pages, 20 figures. Corrected author list; corrected typos across paper and polished text
Published: 2024

28. The DUNE Far Detector Vertical Drift Technology, Technical Design Report

Author: DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Amar, H., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bracinik, J., Braga, D., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calin, M., Calivers, L., Calvo, E., Caminata, A., Campanelli, W., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clair, J., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collot, J., Conley, E., Conrad, J. M., Convery, M., Cooke, P., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., De la Torre, A., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferraro, F., Ferry, G., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A. M., Galizzi, F., Gallagher, H., Gallas, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. M., Gwon, S., Haaf, K., Habig, A., Hadavand, H., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hakenmueller, J., Hamernik, T., Hamilton, P., Hancock, J., Happacher, F., Harris, D. A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C., Hatcher, R., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hewes, V., Higuera, A., Hilgenberg, C., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horton-Smith, G. A., Hostert, M., Houdy, T., Howard, B., Howell, R., Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Ibrahim, M., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jena, D., Ji, X., Jiang, C., Jiang, J., Jiang, L., Jipa, A., Joaquim, F. R., Johnson, W., Jones, B., Jones, R., Fernández, D. José, Jovancevic, N., Judah, M., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A. C., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kamiya, F., Kandemir, M., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kauther, A., Kazaryan, N., Ke, L., Kearns, E., Keener, P. T., Kelly, K. J., Kemp, E., Kemularia, O., Kermaidic, Y., Ketchum, W., Kettell, S. H., Khabibullin, M., Khan, N., Khotjantsev, A., Khvedelidze, A., Kim, D., Kim, J., King, B., Kirby, B., Kirby, M., Kish, A., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koch, L., Koehler, K., Koerner, L. W., Koh, D. H., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kovalcuk, M., Kozhukalov, V., Krah, W., Kralik, R., Kramer, M., Kreczko, L., Krennrich, F., Kreslo, I., Kroupova, T., Kubota, S., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kumaran, S., Kunze, P., Kunzmann, J., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Labree, T., Lackey, T., Lambert, A., Land, B. J., Lane, C. E., Lane, N., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laudrain, A., Laundrie, A., Laurenti, G., Lavaut, E., Lawrence, A., Laycock, P., Lazanu, I., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeCompte, T., Lee, C., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Silverio, D. Leon, Lepin, L. M., Li, J. -Y., Li, S. W., Li, Y., Liao, H., Lin, C. S., Lindebaum, D., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. R., Liu, H., Liu, J., Liu, Y., Lockwitz, S., Lokajicek, M., Lomidze, I., Long, K., Lopes, T. V., Lopez, J., de Rego, I. López, López-March, N., Lord, T., LoSecco, J. M., Louis, W. C., Sanchez, A. Lozano, Lu, X. -G., Luk, K. B., Lunday, B., Luo, X., Luppi, E., Maalmi, J., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., MacMahon, M., Maddalena, A., Madera, A., Madigan, P., Magill, S., Magueur, C., Mahn, K., Maio, A., Major, A., Majumdar, K., Man, M., Mandujano, R. C., Maneira, J., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Corchado, S. Manthey, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marques, F. Das Chagas, Marsden, D., Marshak, M., Marshall, C. M., Marshall, J., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Massari, C., Mastbaum, A., Matichard, F., Matsuno, S., Matteucci, G., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., Mazzacane, A., McAskill, T., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Meazza, L., Meddage, V. C. N., Mefodiev, A., Mehta, B., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Messier, M. D., Metallo, S., Metcalf, J., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Miccoli, A., Michna, G., Mikola, V., Milincic, R., Miller, G., Miller, W., Mineev, O., Minotti, A., Miralles, L., Miranda, O. G., Mironov, C., Miryala, S., Miscetti, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Mooney, M., Moor, A. F., Moore, Z., Moreno, D., Moreno-Palacios, O., Morescalchi, L., Moretti, D., Moretti, R., Morris, C., Mossey, C., Mote, M., Moura, C. A., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Munteanu, L. J., Muramatsu, H., Muraz, J., Murphy, M., Murphy, T., Muse, J., Mytilinaki, A., Nachtman, J., Nagai, Y., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Nath, A., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nehm, A., Nelson, J. K., Neogi, O., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Oh, S., Oh, S. B., Olivier, A., Olshevskiy, A., Olson, T., Onel, Y., Onishchuk, Y., Oranday, A., Osbiston, M., Vélez, J. A. Osorio, Ormachea, L. Otiniano, Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Panda, P., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Papoulias, D., Paramesvaran, S., Paris, A., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Patrick, C., Patrizii, L., Patterson, R. B., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Pedreschi, E., Peeters, S. J. M., Pellico, W., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Gonzalez, Y. F. Perez, Pérez-Molina, L., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pia, V., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Pinchault, J., Plows, K., Plunkett, R., Pollack, C., Pollman, T., Pompa, F., Pons, X., Poonthottathil, N., Poppi, F., Porter, J., Potekhin, M., Potenza, R., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Pratt, C., Prest, M., Prosser, A., Psihas, F., Pugnere, D., Qian, X., Raaf, J. L., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajagopalan, S., Rajaoalisoa, M., Rakhno, I., Rakotondravohitra, L., Ralte, L., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ray, R., Razafinime, H., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reggiani-Guzzo, M., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renner, E., Renshaw, A., Rescia, S., Resnati, F., Restrepo, D., Reynolds, C., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Ricol, J. S., Rigan, M., Rincón, E. V., Ritchie-Yates, A., Ritter, S., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Rosauro-Alcaraz, S., Rosier, P., Ross, D., Rossella, M., Rossi, M., Ross-Lonergan, M., Roy, N., Roy, P., Rubbia, C., Ruggeri, A., Ferreira, G. Ruiz, Russell, B., Ruterbories, D., Rybnikov, A., Saa-Hernandez, A., Saakyan, R., Sacerdoti, S., Sahoo, S. K., Sahu, N., Sakashita, K., Sala, P., Samios, N., Samoylov, O., Sanchez, M. C., Bravo, A. Sánchez, Sanchez-Lucas, P., Sandberg, V., Sanders, D. A., Sankey, D., Santoro, D., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Sarra, I., Savage, G., Savinov, V., Scanavini, G., Scaramelli, A., Scarff, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Schuld, B., Segreto, E., Selyunin, A., Senise, C. R., Sensenig, J., Shaevitz, M. H., Shanahan, P., Sharma, P., Kumar, R., Shaw, K., Shaw, T., Shchablo, K., Shepherd-Themistocleous, C., Sheshukov, A., Shi, W., Shin, S., Shivakoti, S., Shoemaker, I., Shooltz, D., Shrock, R., Siddi, B., Silber, J., Simard, L., Sinclair, J., Sinev, G., Singh, Jaydip, Singh, J., Singh, L., Singh, P., Singh, V., Chauhan, S. Singh, Sipos, R., Sironneau, C., Sirri, G., Siyeon, K., Skarpaas, K., Smedley, J., Smith, E., Smith, J., Smith, P., Smolik, J., Smy, M., Snape, M., Snider, E. L., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Soleti, S. R., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Sousa, A., Soustruznik, K., Spinella, F., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stalder, D., Stancari, M., Stanco, L., Steenis, J., Stein, R., Steiner, H. M., Lisbôa, A. F. Steklain, Stepanova, A., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Subash, J., Surdo, A., Suter, L., Sutera, C. M., Sutton, K., Suvorov, Y., Svoboda, R., Swain, S. K., Szczerbinska, B., Szelc, A. M., Sztuc, A., Taffara, A., Talukdar, N., Tamara, J., Tanaka, H. A., Tang, S., Taniuchi, N., Casanova, A. M. Tapia, Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tatar, E., Tayloe, R., Tedeschi, D., Teklu, A. M., Vidal, J. Tena, Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thiebault, A., Thompson, A., Thorn, C., Timm, S. C., Tiras, E., Tishchenko, V., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Travaglini, R., Trevor, J., Triller, E., Trilov, S., Truncali, D., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tu, S. Z., Tufanli, S., Turner, J., Tuzi, M., Tyler, J., Tyley, E., Tzanov, M., Uchida, M. A., González, J. Ureña, Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Van Berg, R., Van de Water, R. G., Forero, D. V., Van Nuland-Troost, M., Varanini, F., Oliva, D. Vargas, Varner, G., Vasina, S., Vaughan, N., Vaziri, K., Vega, J., Ventura, S., Verdugo, A., Vergani, S., Verzocchi, M., Vetter, K., Vicenzi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Villa, E., Viren, B., Vizcaya-Hernandez, A., Vrba, T., Vuong, Q., Waldron, A. V., Wallbank, M., Walsh, J., Walton, T., Wang, H., Wang, J., Wang, L., Wang, M. H. L. S., Wang, X., Wang, Y., Warburton, K., Warner, D., Warsame, L., Wascko, M. O., Waters, D., Watson, A., Wawrowska, K., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenzel, H., Westerdale, S., Wetstein, M., Whalen, K., Whilhelmi, J., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, A., Wilkinson, C., Wilson, F., Wilson, R. J., Winter, P., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zapata, O., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals., Comment: 425 pages; 281 figures Central editing team: A. Heavey, S. Kettell, A. Marchionni, S. Palestini, S. Rajogopalan, R. J. Wilson
Published: 2023

29. Contribution of Microorganisms with the Clade II Nitrous Oxide Reductase to Suppression of Surface Emissions of Nitrous Oxide

Author: Hunt, Kristopher A, Carr, Alex V, Otwell, Anne E, Valenzuela, Jacob J, Walker, Kathleen S, Dixon, Emma R, Lui, Lauren M, Nielsen, Torben N, Bowman, Samuel, von Netzer, Frederick, Moon, Ji-Won, Schadt, Christopher W, Rodriguez, Miguel, Lowe, Kenneth, Joyner, Dominique, Davis, Katherine J, Wu, Xiaoqin, Chakraborty, Romy, Fields, Matthew W, Zhou, Jizhong, Hazen, Terry C, Arkin, Adam P, Wankel, Scott D, Baliga, Nitin S, and Stahl, David A
Subjects: Engineering, Environmental Sciences, Environmental Engineering, Nitrous Oxide, Bacteria, Oxidoreductases, Denitrification, nitrous oxide, denitrification, chemodenitrification, nosZ, isotopic fractionation, flux, pH
Abstract: The sources and sinks of nitrous oxide, as control emissions to the atmosphere, are generally poorly constrained for most environmental systems. Initial depth-resolved analysis of nitrous oxide flux from observation wells and the proximal surface within a nitrate contaminated aquifer system revealed high subsurface production but little escape from the surface. To better understand the environmental controls of production and emission at this site, we used a combination of isotopic, geochemical, and molecular analyses to show that chemodenitrification and bacterial denitrification are major sources of nitrous oxide in this subsurface, where low DO, low pH, and high nitrate are correlated with significant nitrous oxide production. Depth-resolved metagenomes showed that consumption of nitrous oxide near the surface was correlated with an enrichment of Clade II nitrous oxide reducers, consistent with a growing appreciation of their importance in controlling release of nitrous oxide to the atmosphere. Our work also provides evidence for the reduction of nitrous oxide at a pH of 4, well below the generally accepted limit of pH 5.
Published: 2024

30. Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease

Author: Li, Zhen, Gu, Min, Zaparte, Aline, Fu, Xiaoming, Mahen, Kala, Mrdjen, Marko, Li, Xinmin S., Yang, Zhihong, Ma, Jing, Thoudam, Themis, Chandler, Kristina, Hesler, Maggie, Heathers, Laura, Gorse, Kiersten, Van, Thanh Trung, Wong, David, Gibson, Aaron M., Wang, Zeneng, Taylor, Christopher M., Quijada, Pearl, Makarewich, Catherine A., Hazen, Stanley L., Liangpunsakul, Suthat, Brown, J. Mark, Lefer, David J., Welsh, David A., and Sharp, III, Thomas E.
Published: 2024
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31. The doctor will polygraph you now

Author: Anibal, James, Gunkel, Jasmine, Awan, Shaheen, Huth, Hannah, Nguyen, Hang, Le, Tram, Bélisle-Pipon, Jean-Christophe, Boyer, Micah, Hazen, Lindsey, Bensoussan, Yael, Clifton, David, and Wood, Bradford
Published: 2024
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32. Kinetics of imidazole propionate from orally delivered histidine in mice and humans

Author: Warmbrunn, Moritz V., Attaye, Ilias, Horak, Anthony, Banerjee, Rakhee, Massey, William J., Varadharajan, Venkateshwari, Rampanelli, Elena, Hao, Youling, Dutta, Sumita, Nemet, Ina, Aron-Wisnewsky, Judith, Clément, Karine, Koopen, Annefleur, Wortelboer, Koen, Bergh, Per-Olof, Davids, Mark, Mohamed, Nadia, Kemper, E. Marleen, Hazen, Stanley, Groen, Albert K., van Raalte, Daniel H., Herrema, Hilde, Backhed, Fredrik, Brown, J. Mark, and Nieuwdorp, Max
Published: 2024
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33. Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors

Author: Saha, Prasenjit Prasad, Gogonea, Valentin, Sweet, Wendy, Mohan, Maradumane L., Singh, Khuraijam Dhanachandra, Anderson, James T., Mallela, Deepthi, Witherow, Conner, Kar, Niladri, Stenson, Kate, Harford, Terri, Fischbach, Michael A., Brown, J. Mark, Karnik, Sadashiva S., Moravec, Christine S., DiDonato, Joseph A., Naga Prasad, Sathyamangla Venkata, and Hazen, Stanley L.
Published: 2024
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34. Long-distance communication can enable collective migration in a dynamic seascape

Author: Dodson, Stephanie, Oestreich, William K., Savoca, Matthew S., Hazen, Elliott L., Bograd, Steven J., Ryan, John P., Fiechter, Jerome, and Abrahms, Briana
Published: 2024
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35. Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism

Author: Wahlström, Annika, Brumbaugh, Ariel, Sjöland, Wilhelm, Olsson, Lisa, Wu, Hao, Henricsson, Marcus, Lundqvist, Annika, Makki, Kassem, Hazen, Stanley L., Bergström, Göran, Marschall, Hanns-Ulrich, Fischbach, Michael A., and Bäckhed, Fredrik
Published: 2024
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36. Non-dispensing pharmacists integrated into general practices as a new interprofessional model: a qualitative evaluation of general practitioners’ experiences and views

Author: Hazen, A.C.M., Sloeserwij, V.M., de Groot, E., de Gier, J.J., de Wit, N.J., de Bont, A.A., and Zwart, D.L.M.
Published: 2024
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37. Beyond boundaries: governance considerations for climate-driven habitat shifts of highly migratory marine species across jurisdictions

Author: Santos, Bianca S., Hazen, Elliott L., Welch, Heather, Lezama-Ochoa, Nerea, Block, Barbara A., Costa, Daniel P., Shaffer, Scott A., and Crowder, Larry B.
Published: 2024
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38. Cooperative control of a DNA origami force sensor

Author: Robbins, Ariel, Hildebolt, Hazen, Neuhoff, Michael, Beshay, Peter, Winter, Jessica O., Castro, Carlos E., Bundschuh, Ralf, and Poirier, Michael G.
Published: 2024
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39. Siklus hidup dan statistik demografi kutukebul Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) biotipe B dan non-B pada tanaman cabai (Capsicum annuum L.)

Author: Purnama Hidayat, Hazen Arrazie Kurniawan, Lutfi Afifah, and Hermanu Triwidodo
Subjects: siklus hidup, statistik demografi, pertambuhan intrinsik, reproduksi, Zoology, QL1-991
Abstract: The whitefly Bemisia tabaci (Gennadius) biotype B also known as Bemisia argentifolii (Gennadius) is a more malignant whitefly biotype in damaging plants compared to non-B biotype. Currently the whitefly B. tabaci biotype B has been reported to exist in Indonesia. Basic information such as life cycle, length of life, fecundity, and breeding ability of a whitefly is important information as a basis in preparing the whitefly control strategy. The aim of this research was to study the life cycle and demographic statistic of the B. tabaci biotype B and the non-B biotype on chili pepper. The study was conducted by observing the development of the whiteflies from eggs to adult in a growth chamber that the temperature and lighting were controlled. Observations were made on several aspects of biology and some parameters of demographic statistics. The results showed that the biotype B of B. tabaci has several different biological aspects with the non-B whitefly in chili pepper. The life cycle of the biotype B of B. tabaci and the non-B were different, 33.27 and 30.86 days respectively. The biotype B of B. tabaci had a net reproduction rate (R0) which was similar to that of the non-B biotype as well as the average of its generation. However, the intrinsic increase rate (r) of the biotype B B. tabaci was 2.5 times shorter than the non-B biotype. The biotype B of B. tabaci doubled its population (DT) 2 times faster than the non-B biotype. It is clear that the biotype B of B. tabaci potentially more dangerous than the non-B.
Published: 2018
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40. Submesoscale coupling of krill and whales revealed by aggregative Lagrangian coherent structures.

Author: Fahlbusch, James, Cade, David, Hazen, Elliott, Elliott, Meredith, Saenz, Benjamin, Goldbogen, Jeremy, and Jahncke, Jaime
Subjects: Lagrangian coherent structures, california current system, cetaceans, finite-time Lyapunov exponent (ftle), krill, physical–biological coupling, Animals, Whales, Ecosystem, Euphausiacea, Seawater
Abstract: In the marine environment, dynamic physical processes shape biological productivity and predator-prey interactions across multiple scales. Identifying pathways of physical-biological coupling is fundamental to understand the functioning of marine ecosystems yet it is challenging because the interactions are difficult to measure. We examined submesoscale (less than 100 km) surface current features using remote sensing techniques alongside ship-based surveys of krill and baleen whale distributions in the California Current System. We found that aggregative surface current features, represented by Lagrangian coherent structures (LCS) integrated over temporal scales between 2 and 10 days, were associated with increased (a) krill density (up to 2.6 times more dense), (b) baleen whale presence (up to 8.3 times more likely) and (c) subsurface seawater density (at depths up to 10 m). The link between physical oceanography, krill density and krill-predator distributions suggests that LCS are important features that drive the flux of energy and nutrients across trophic levels. Our results may help inform dynamic management strategies aimed at reducing large whales ship strikes and help assess the potential impacts of environmental change on this critical ecosystem.
Published: 2024

41. Divergent responses of highly migratory species to climate change in the California Current

Author: Lezama‐Ochoa, Nerea, Brodie, Stephanie, Welch, Heather, Jacox, Michael G, Buil, Mercedes Pozo, Fiechter, Jerome, Cimino, Megan, Muhling, Barbara, Dewar, Heidi, Becker, Elizabeth A, Forney, Karin A, Costa, Daniel, Benson, Scott R, Farchadi, Nima, Braun, Camrin, Lewison, Rebecca, Bograd, Steven, and Hazen, Elliott L
Subjects: Environmental Sciences, Biological Sciences, Environmental Management, Life on Land, Climate Action, California Current System, centre of gravity, climate change, downscaled ocean projections, earth system model, habitat suitability index, species distribution model, Ecology, Biological sciences, Environmental sciences
Abstract: Aim: Marine biodiversity faces unprecedented threats from anthropogenic climate change. Ecosystem responses to climate change have exhibited substantial variability in the direction and magnitude of redistribution, posing challenges for developing effective climate-adaptive marine management strategies. Location: The California Current Ecosystem (CCE), USA. Methods: We project suitable habitat for 10 highly migratory species in the California Current System using an ensemble of three high-resolution (~10 km) downscaled ocean projections under the Representative Concentration Pathway 8.5 (RCP8.5). Spanning the period from 1980 to 2100, our analysis focuses on assessing the direction and distance of distributional shifts, as well as changes in core habitat area for each species. Results: Our findings reveal a divergent response among species to climate impacts. Specifically, four species were projected to undergo significant poleward shifts exceeding 100 km, and gain habitat (~7%–60%) in response to climate change. Conversely, six species were projected to shift towards the coast, resulting in a loss of habitat ranging from 10% to 66% by the end of the century. These divergent responses could typically be characterized by the mode of thermoregulation (i.e. ectotherm vs. endotherm) and species' affiliations with cool and productive upwelled waters that are characteristic of the region. Furthermore, our study highlights an increase in niche overlap between protected species and those targeted by fisheries, which may lead to increased human interaction events under climate change. Main Conclusions: By providing valuable species distribution projections, our research contributes to the understanding of climate change effects on marine biodiversity and offers critical insight and support for developing climate-ready management of protected and fished species.
Published: 2024

42. Designing an all-flash Lustre file system for the 2020 NERSC Perlmutter system

Author: Lockwood, Glenn K, Lozinskiy, Kirill, Gerhardt, Lisa, Cheema, Ravi, Hazen, Damian, and Wright, Nicholas J
Subjects: lustre, architecture, storage, flash
Published: 2024

43. Mixed waste contamination selects for a mobile genetic element population enriched in multiple heavy metal resistance genes

Author: Goff, Jennifer L, Lui, Lauren M, Nielsen, Torben N, Poole, Farris L, Smith, Heidi J, Walker, Kathleen F, Hazen, Terry C, Fields, Matthew W, Arkin, Adam P, and Adams, Michael WW
Subjects: Microbiology, Biological Sciences, Ecology, Genetics, mobilome, plasmids, phages, evolution, metagenome
Abstract: Mobile genetic elements (MGEs) like plasmids, viruses, and transposable elements can provide fitness benefits to their hosts for survival in the presence of environmental stressors. Heavy metal resistance genes (HMRGs) are frequently observed on MGEs, suggesting that MGEs may be an important driver of adaptive evolution in environments contaminated with heavy metals. Here, we report the meta-mobilome of the heavy metal-contaminated regions of the Oak Ridge Reservation subsurface. This meta-mobilome was compared with one derived from samples collected from unimpacted regions of the Oak Ridge Reservation subsurface. We assembled 1615 unique circularized DNA elements that we propose to be MGEs. The circular elements from the highly contaminated subsurface were enriched in HMRG clusters relative to those from the nearby unimpacted regions. Additionally, we found that these HMRGs were associated with Gamma and Betaproteobacteria hosts in the contaminated subsurface and potentially facilitate the persistence and dominance of these taxa in this region. Finally, the HMRGs were associated with conjugative elements, suggesting their potential for future lateral transfer. We demonstrate how our understanding of MGE ecology, evolution, and function can be enhanced through the genomic context provided by completed MGE assemblies.
Published: 2024

44. Experiences in deploying in-network data caches

Author: Sim, Alex, Kissel, Ezra, Hazen, Damian, and Guok, Chin
Subjects: Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Particle and high energy physics, Synchrotrons and accelerators
Abstract: Data caches of various forms have been widely deployed in the context of commercial and research and education networks, but their common positioning at the Edge limits their utility from a network operator perspective. When deployed outside the network core, providers lack visibility to make decisions or apply traffic engineering based on data access patterns and caching node location. As an alternative, in-network caching provides a different type of content delivery network for scientific data infrastructure, supporting on-demand temporary caching service. We will describe the status of in-network caching nodes deployed within ESnet in support of the US CMS data federation. We will describe the container and networking architecture used to deploy data caches within ESnet, and update on the evolving tooling around service management lifecycle. An analysis of cache usage will also be provided along with an outlook for expanding the in-network cache footprint.
Published: 2024

45. Potential applications of microbial genomics in nuclear non-proliferation.

Author: MacGregor, Heather, Fukai, Isis, Ash, Kurt, Arkin, Adam, and Hazen, Terry
Subjects: environmental bioindicators, microbial ecology, microbial genomics, nuclear non-proliferation, radionuclides, systems biology
Abstract: As nuclear technology evolves in response to increased demand for diversification and decarbonization of the energy sector, new and innovative approaches are needed to effectively identify and deter the proliferation of nuclear arms, while ensuring safe development of global nuclear energy resources. Preventing the use of nuclear material and technology for unsanctioned development of nuclear weapons has been a long-standing challenge for the International Atomic Energy Agency and signatories of the Treaty on the Non-Proliferation of Nuclear Weapons. Environmental swipe sampling has proven to be an effective technique for characterizing clandestine proliferation activities within and around known locations of nuclear facilities and sites. However, limited tools and techniques exist for detecting nuclear proliferation in unknown locations beyond the boundaries of declared nuclear fuel cycle facilities, representing a critical gap in non-proliferation safeguards. Microbiomes, defined as characteristic communities of microorganisms found in specific habitats with distinct physical and chemical properties, can provide valuable information about the conditions and activities occurring in the surrounding environment. Microorganisms are known to inhabit radionuclide-contaminated sites, spent nuclear fuel storage pools, and cooling systems of water-cooled nuclear reactors, where they can cause radionuclide migration and corrosion of critical structures. Microbial transformation of radionuclides is a well-established process that has been documented in numerous field and laboratory studies. These studies helped to identify key bacterial taxa and microbially-mediated processes that directly and indirectly control the transformation, mobility, and fate of radionuclides in the environment. Expanding on this work, other studies have used microbial genomics integrated with machine learning models to successfully monitor and predict the occurrence of heavy metals, radionuclides, and other process wastes in the environment, indicating the potential role of nuclear activities in shaping microbial community structure and function. Results of this previous body of work suggest fundamental geochemical-microbial interactions occurring at nuclear fuel cycle facilities could give rise to microbiomes that are characteristic of nuclear activities. These microbiomes could provide valuable information for monitoring nuclear fuel cycle facilities, planning environmental sampling campaigns, and developing biosensor technology for the detection of undisclosed fuel cycle activities and proliferation concerns.
Published: 2024

46. Predicting Resource Utilization Trends with Southern California Petabyte Scale Cache

Author: Sim, Caitlin, Wu, Kesheng, Sim, Alex, Monga, Inder, Guok, Chin, Hazen, Damian, Würthwein, Frank, Davila, Diego, Newman, Harvey, and Balcas, Justas
Subjects: Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Particle and high energy physics, Synchrotrons and accelerators
Abstract: Large community of high-energy physicists share their data all around world making it necessary to ship a large number of files over wide- area networks. Regional disk caches such as the Southern California Petabyte Scale Cache have been deployed to reduce the data access latency. We observe that about 94% of the requested data volume were served from this cache, without remote transfers, between Sep. 2022 and July 2023. In this paper, we show the predictability of the resource utilization by exploring the trends of recent cache usage. The time series based prediction is made with a machine learning approach and the prediction errors are small relative to the variation in the input data. This work would help understanding the characteristics of the resource utilization and plan for additional deployments of caches in the future.
Published: 2024

47. Impact of prescribed fire on soil microbial communities in a Southern Appalachian Forest clear-cut.

Author: Rafie, S, Blentlinger, L, Putt, A, Williams, D, Joyner, D, Campa, M, Schubert, M, Hoyt, K, Horn, S, Franklin, J, and Hazen, Terry
Subjects: microbial diversity, nutrient cycling, prescribed fire, soil microbiome, soil recovery
Abstract: Escalating wildfire frequency and severity, exacerbated by shifting climate patterns, pose significant ecological and economic challenges. Prescribed burns, a common forest management tool, aim to mitigate wildfire risks and protect biodiversity. Nevertheless, understanding the impact of prescribed burns on soil and microbial communities in temperate mixed forests, considering temporal dynamics and slash fuel types, remains crucial. Our study, conducted at the University of Tennessee Forest Resources AgResearch and Education Center in Oak Ridge, TN, employed controlled burns across various treatments, and the findings indicate that low-intensity prescribed burns have none or minimal short-term effects on soil parameters but may alter soil nutrient concentrations, as evidenced by significant changes in porewater acetate, formate, and nitrate concentrations. These burns also induce shifts in microbial community structure and diversity, with Proteobacteria and Acidobacteria increasing significantly post-fire, possibly aiding soil recovery. In contrast, Verrucomicrobia showed a notable decrease over time, and other specific microbial taxa correlated with soil pH, porewater nitrate, ammonium, and phosphate concentrations. Our research contributes to understanding the intricate relationships between prescribed fire, soil dynamics, and microbial responses in temperate mixed forests in the Southern Appalachian Region, which is valuable for informed land management practices in the face of evolving environmental challenges.
Published: 2024

48. Prevalence of micronutrient deficiencies across diverse environments in rural Madagascar.

Author: Golden, Christopher, Zamborain-Mason, Jessica, Levis, Alexander, Rice, Benjamin, Allen, Lindsay, Hampel, Daniela, Hazen, James, Metcalf, C, Randriamady, Hervet, Shahab-Ferdows, Setareh, Wu, Stephanie, and Haneuse, Sebastien
Subjects: food security, inflammation, iron deficiency, micronutrient deficiencies, vitamin A, vitamin B12, vitamin deficiency, zinc deficiency
Abstract: It is estimated that billions of people around the world are affected by micronutrient deficiencies. Madagascar is considered to be particularly nutritionally vulnerable, with nearly half of the population stunted, and parts of the country facing emergency, near famine-like conditions (IPC4). Although Madagascar is generally considered among the most undernourished of countries, empirical data in the form of biological samples to validate these claims are extremely limited. Our research drew data from three studies conducted between 2013-2020 and provided comprehensive biomarker profile information for 4,710 individuals from 30 communities in five different ecological regions during at least one time-point. Estimated prevalences of nutrient deficiencies and inflammation across various regions of rural Madagascar were of concern for both sexes and across all ages, with 66.5% of the population estimated to be deficient in zinc, 15.6% depleted in vitamin B12 (3.6% deficient), 11.6% deficient in retinol, and lower levels of iron deficiency (as indicated by 11.7% deficient in ferritin and 2.3% deficient assessed by soluble transferrin receptors). Beyond nutrient status biomarkers, nearly one quarter of the population (24.0%) exhibited chronic inflammation based on high values of α-1-acid glycoprotein, and 12.3% exhibited acute inflammation based on high values of C-reactive protein. There is an 8-fold difference between the lowest and highest regional observed prevalence of vitamin B12 deficiency, a 10-fold difference in vitamin A deficiency (based on retinol), and a 2-fold difference in acute inflammation (CRP) and deficiencies of zinc and iron (based on ferritin), highlighting strong geographical variations in micronutrient deficiencies across Madagascar.
Published: 2024

49. Mechanically induced localisation of SECONDARY WALL INTERACTING bZIP is associated with thigmomorphogenic and secondary cell wall gene expression.

Author: Coomey, Joshua, MacKinnon, Kirk, McCahill, Ian, Khahani, Bahman, Handakumbura, Pubudu, Trabucco, Gina, Mazzola, Jessica, Leblanc, Nicole, Kheam, Rithany, Hernandez-Romero, Miriam, Barry, Kerrie, Liu, Lifeng, Lee, Ji, Vogel, John, OMalley, Ronan, Chambers, James, and Hazen, Samuel
Subjects: gene expression, secondary cell wall, thigmomorphogenesis
Abstract: Plant growth requires the integration of internal and external cues, perceived and transduced into a developmental programme of cell division, elongation and wall thickening. Mechanical forces contribute to this regulation, and thigmomorphogenesis typically includes reducing stem height, increasing stem diameter, and a canonical transcriptomic response. We present data on a bZIP transcription factor involved in this process in grasses. Brachypodium distachyon SECONDARY WALL INTERACTING bZIP (SWIZ) protein translocated into the nucleus following mechanostimulation. Classical touch-responsive genes were upregulated in B. distachyon roots following touch, including significant induction of the glycoside hydrolase 17 family, which may be unique to grass thigmomorphogenesis. SWIZ protein binding to an E-box variant in exons and introns was associated with immediate activation followed by repression of gene expression. SWIZ overexpression resulted in plants with reduced stem and root elongation. These data further define plant touch-responsive transcriptomics and physiology, offering insights into grass mechanotranduction dynamics.
Published: 2024

50. COVID-19 trends at the University of Tennessee: predictive insights from raw sewage SARS-CoV-2 detection and evaluation and PMMoV as an indicator for human waste.

Author: Li, Ye, Ash, Kurt, Alamilla, Isablla, Joyner, Dominique, Williams, Daniel, McKay, Peter, Green, Brianna, DeBlander, Sydney, North, Carman, Kara-Murdoch, Fadime, Swift, Cynthia, and Hazen, Terry
Subjects: COVID-19, PMMoV, RT-qPCR, SARS-CoV-2, WBE, raw wastewater, sewage
Abstract: Wastewater-based epidemiology (WBE) has become a valuable tool for monitoring the prevalence of SARS-CoV-2 on university campuses. However, concerns about effectiveness of raw sewage as a COVID-19 early warning system still exist, and its not clear how useful normalization by simultaneous comparison of Pepper Mild Mottle Virus (PMMoV) is in addressing variations resulting from fecal discharge dilution. This study aims to contribute insights into these aspects by conducting an academic-year field trial at the student residences on the University of Tennessee, Knoxville campus, raw sewage. This was done to investigate the correlations between SARS-CoV-2 RNA load, both with and without PMMoV normalization, and various parameters, including active COVID-19 cases, self-isolations, and their combination among all student residents. Significant positive correlations between SARS-CoV-2 RNA load a week prior, during the monitoring week, and the subsequent week with active cases. Despite these correlations, normalization by PMMoV does not enhance these associations. These findings suggest the potential utility of SARS-CoV-2 RNA load as an early warning indicator and provide valuable insights into the application and limitations of WBE for COVID-19 surveillance specifically within the context of raw sewage on university campuses.
Published: 2024

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