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An exciting prospect in the field of magnetic fluid hyperthermia (MFH) has been the integration of noble rare earth elements (Eu) with biopolymers (chitosan/dextran) that have optimum structures to tune specific effects on magnetic nanoparticles (NPs). However, the heating efficiency of MNPs is primarily influenced by their magnetization, size distribution, magnetic anisotropy, dipolar interaction, amplitude, and frequency of the applied field, the MNPs with high heating efficiency are still challenging. In this study, a comprehensive experimental analysis has been conducted on single-domain magnetic nanoparticles (SDMNPs) for evaluating effective anisotropy, assessing the impact of particle-intrinsic factors and experimental conditions on self-heating efficiency in both noninteracting and interacting systems, with a particular focus on the dipolar interaction effect. The study successfully reconciles conflicting findings on the interaction effects in the agglomeration and less agglomerated arrangements for MFH applications. The results suggest that effective control of dipolar interactions can be achieved by encapsulating Chitosan/Dextran in the synthesized MNPs. The lower dipolar interactions successfully tune the self-heating efficiency and hold promise as potential candidates for MFH applications. [ABSTRACT FROM AUTHOR]

Magnetite (Fe3O4) nanoparticle (MNP)-substituted glass-ceramic (MSGC) powders with compositions of (45 − x)SiO2–24.5CaO–24.5Na2O–6P2O5–xFe3O4 (x = 5, 8, and 10 wt%) have been prepared by a sol–gel route by introducing Fe3O4 nanoparticles during the synthesis. The X-ray diffraction patterns of the as-prepared MSGC nanopowders revealed the presence of combeite (Na2Ca2Si3O9), magnetite, and sodium nitrate (NaNO3) crystalline phases. Heat-treatment up to 700 °C for 1 h resulted in the complete dissolution of NaNO3 along with partial conversion of magnetite into hematite (α-Fe2O3). Optimal heat-treatment of the MSGC powders at 550 °C for 1 h yielded the highest relative percentage of magnetite (without hematite) with some residual NaNO3. The saturation magnetization and heat generation capacity of the MSGC fluids increased with an increase in the MNP content. The in vitro bioactivity of the MSGC pellets was evaluated by monitoring the pH and the formation of a hydroxyapatite surface layer upon immersion in modified simulated body fluid. Proliferation of MG-63 osteoblast cells indicated that all of the MSGC compositions were non-toxic and MSGC with 10 wt% MNPs exhibited extraordinarily high cell viability. The MSGC with 10 wt% MNPs demonstrated optimal characteristics in terms of cell viability, magnetic properties, and induction heating capacity, which surpass those of the commercial magnetic fluid FluidMag-CT employed in hyperthermia treatment. [ABSTRACT FROM AUTHOR]

An exciting prospect in the field of magnetic fluid hyperthermia (MFH) has been the integration of noble rare earth elements with biopolymers (chitosan/dextran) that have optimum structures to tune specific effects on magnetic nanoparticles (MNPs). Remarkably, it has been demonstrated that dipole–dipole interactions have a significant influence on nanoparticle dynamics. In this article, we present an exhaustive scrutiny of dipolar interactions and how this affects the efficiency of MFH applications. In particular, we prepare chitosan and dextran-coated Tb-doped MNPs and study whether it is possible to increase the heat released by controlling the dipole–dipole interactions. It has been indicated that even moderate control of agglomeration may substantially impact the structure and magnetization dynamics of the system. Besides estimating the specific loss power value, our findings provide a deep insight into the relaxation mechanisms and bring to light how to tune the self-heating efficacy towards magnetic hyperthermia. [ABSTRACT FROM AUTHOR]

Magnetite (Fe 3 O 4 ) nanoparticle (MNP)-substituted glass-ceramic (MSGC) powders with compositions of (45 - x )SiO 2 -24.5CaO-24.5Na 2 O-6P 2 O 5 - x Fe 3 O 4 ( x = 5, 8, and 10 wt%) have been prepared by a sol-gel route by introducing Fe 3 O 4 nanoparticles during the synthesis. The X-ray diffraction patterns of the as-prepared MSGC nanopowders revealed the presence of combeite (Na 2 Ca 2 Si 3 O 9 ), magnetite, and sodium nitrate (NaNO 3 ) crystalline phases. Heat-treatment up to 700 °C for 1 h resulted in the complete dissolution of NaNO 3 along with partial conversion of magnetite into hematite (α-Fe 2 O 3 ). Optimal heat-treatment of the MSGC powders at 550 °C for 1 h yielded the highest relative percentage of magnetite (without hematite) with some residual NaNO 3 . The saturation magnetization and heat generation capacity of the MSGC fluids increased with an increase in the MNP content. The in vitro bioactivity of the MSGC pellets was evaluated by monitoring the pH and the formation of a hydroxyapatite surface layer upon immersion in modified simulated body fluid. Proliferation of MG-63 osteoblast cells indicated that all of the MSGC compositions were non-toxic and MSGC with 10 wt% MNPs exhibited extraordinarily high cell viability. The MSGC with 10 wt% MNPs demonstrated optimal characteristics in terms of cell viability, magnetic properties, and induction heating capacity, which surpass those of the commercial magnetic fluid FluidMag-CT employed in hyperthermia treatment.