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1. Search for Nucleon Decay into Charged Anti-lepton plus Meson in Super-Kamiokande I and II

Author

Collaboration, Super-Kamiokande, Nishino, H., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Kameda, J., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Hazama, S., Higuchi, I., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Mitsuka, G., Okumura, K., Tanimoto, N., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Yokoyama, M., Fukuda, Y., Itow, Y., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Idehara, Y., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Seo, H. K., Furuse, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Vagins, M. R., Chen, S., Heng, Y., Liu, J., Yang, Z., Zhang, H., Kielczewska, D., Connolly, K., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

Searches for a nucleon decay into a charged anti-lepton (e^+ or {\mu}^+) plus a light meson ({\pi}^0, {\pi}^-, {\eta}, {\rho}^0, {\rho}^-, {\omega}) were performed using the Super-Kamiokande I and II data. Twelve nucleon decay modes were searched for. The total exposure is 140.9 kiloton \cdot years, which includes a 91.7 kiloton \cdot year exposure (1489.2 live days) of Super-Kamiokande-I and a 49.2 kiloton \cdot year exposure (798.6 live days) of Super-Kamiokande-II. The number of candidate events in the data was consistent with the atmospheric neutrino background expectation. No significant evidence for a nucleon decay was observed in the data. Thus, lower limits on the nucleon partial lifetime at 90% confidence level were obtained. The limits range from 3.6 \times 10^31 to 8.2 \times 10^33 years, depending on the decay modes., Comment: 25 pages, 18 figures

Published
2012
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2. Study of Non-Standard Neutrino Interactions with Atmospheric Neutrino Data in Super-Kamiokande I and II

Author

Mitsuka, G., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Kameda, J., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Hazama, S., Higuchi, I., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Nishino, H., Okumura, K., Tanimoto, N., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Goldhaber, M., Bays, K., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Vagins, M. R., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Scholberg, K., Walter, C. W., Wendell, R., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Yokoyama, M., Fukuda, Y., Itow, Y., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Idehara, Y., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Seo, H. K., Furuse, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Chen, S., Liu, J., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Connolly, K., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

In this paper we study non-standard neutrino interactions as an example of physics beyond the standard model using atmospheric neutrino data collected during the Super-Kamiokande I(1996-2001) and II(2003-2005) periods. We focus on flavor-changing-neutral-currents (FCNC), which allow neutrino flavor transitions via neutral current interactions, and effects which violate lepton non-universality (NU) and give rise to different neutral-current interaction-amplitudes for different neutrino flavors. We obtain a limit on the FCNC coupling parameter, varepsilon_{mu tau}, |varepsilon_{mu tau}|<1.1 x 10^{-2} at 90%C.L. and various constraints on other FCNC parameters as a function of the NU coupling, varepsilon_{e e}. We find no evidence of non-standard neutrino interactions in the Super-Kamiokande atmospheric data., Comment: 12 Pages, 14 figures. To be submitted to Phys. Rev. D

Published
2011
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3. An Indirect Search for WIMPs in the Sun using 3109.6 days of upward-going muons in Super-Kamiokande

Author

Collaboration, The Super-Kamiokande, Tanaka, T., Abe, K., Hayato, Y., Iida, T., Kameda, J., Koshio, Y., Kouzuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Yamada, S., Yokozawa, T., Ishihara, C., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Dufour, F., Kearns, E., Litos3, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Cravens, J. P., Bays, K., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S., Martens, K., Vagins, M., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Minamino, A., Nakaya, T., Labarga, L., Fukuda, Y., Itow, Y., Mitsuka, G., Jung, C. K., McGrew, C., Lopez, G., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

We present the result of an indirect search for high energy neutrinos from WIMP annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Datasets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C.L. upper limits of upward-going muon flux induced by WIMPs of 100 GeV/c$^2$ were 6.4$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ and 4.0$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5$\times10^{-39}$ cm$^{-2}$ and 2.7$\times10^{-40}$ cm$^{-2}$ for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively., Comment: Add journal reference. Also fixed typo and cosmetic things in the old draft

Published
2011
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4. Solar neutrino results in Super-Kamiokande-III

Author

Abe, K., Hayato, Y., Iida, T., Ikeda, M., Ishihara, C., Iyogi, K., Kameda, J., Kobayashi, K., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Yokozawa, T., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Vagins, M. R., Labarga, L., Magro, L. M, Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Wang, W., Goldhaber, M., Bays, K., Casper, D., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Renshaw, A., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Wendell, R., Wongjirad, T., Scholberg, K., Walter, C. W., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Terri, R., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

The results of the third phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first and second phase results. With improved detector calibrations, a full detector simulation, and improved analysis methods, the systematic uncertainty on the total neutrino flux is estimated to be ?2.1%, which is about two thirds of the systematic uncertainty for the first phase of Super-Kamiokande. The observed 8B solar flux in the 5.0 to 20 MeV total electron energy region is 2.32+/-0.04 (stat.)+/-0.05 (sys.) *10^6 cm^-2sec^-1, in agreement with previous measurements. A combined oscillation analysis is carried out using SK-I, II, and III data, and the results are also combined with the results of other solar neutrino experiments. The best-fit oscillation parameters are obtained to be sin^2 {\theta}12 = 0.30+0.02-0.01(tan^2 {\theta}12 = 0.42+0.04 -0.02) and {\Delta}m2_21 = 6.2+1.1-1.9 *10^-5eV^2. Combined with KamLAND results, the best-fit oscillation parameters are found to be sin^2 {\theta}12 = 0.31+/-0.01(tan^2 {\theta}12 = 0.44+/-0.03) and {\Delta}m2_21 = 7.6?0.2*10^-5eV^2 . The 8B neutrino flux obtained from global solar neutrino experiments is 5.3+/-0.2(stat.+sys.)*10^6cm^-2s^-1, while the 8B flux becomes 5.1+/-0.1(stat.+sys.)*10^6cm^-2s^-1 by adding KamLAND result. In a three-flavor analysis combining all solar neutrino experiments, the upper limit of sin^2 {\theta}13 is 0.060 at 95% C.L.. After combination with KamLAND results, the upper limit of sin^2 {\theta}13 is found to be 0.059 at 95% C.L.., Comment: 19 pages, 33 figures in the main text. The appendix section on errata is added in v3

Published
2010
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5. Atmospheric neutrino oscillation analysis with sub-leading effects in Super-Kamiokande I, II, and III

Author

Collaboration, Super-Kamiokande, Wendell, R., Ishihara, C., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Iyogi, K., Kameda, J., Kobayashi, K., Koshio, Y., Kozuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Watanabe, H., Yamada, S., Yokozawa, T., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Vagins, M. R., Dufour, F., Kearns, E., Litos, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Wang, W., Goldhaber, M., Bays, K., Casper, D., Cravens, J. P., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J., Fechner, M., Scholberg, K., Walter, C. W., Tasaka, S., Learned, J. G., Matsuno, S., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Minamino, A., Nakaya, T., Fukuda, Y., Itow, Y., Mitsuka, G., Tanaka, T., Jung, C. K., Lopez, G., McGrew, C., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Mino, S., Mori, T., Sakuda, M., Toyota, H., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Ishizuka, T., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Yokoyama, M., Totsuka, Y., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for non-zero theta_{13} and deviations of sin^2 theta_{23} from 0.5 in the oscillations of atmospheric neutrino data from Super-Kamiokande -I, -II, and -III. No distortions of the neutrino flux consistent with non-zero theta_{13} are found and both neutrino mass hierarchy hypotheses are in agreement with the data. The data are best fit at Delta m^2 = 2.1 x 10^-3 eV^2, sin^2 theta_{13} = 0.0, and sin^2 theta_{23} =0.5. In the normal (inverted) hierarchy theta_{13} and Delta m^2 are constrained at the one-dimensional 90% C.L. to sin^2 theta_{13} < 0.04 (0.09) and 1.9 (1.7) x 10^-3 < Delta m^2 < 2.6 (2.7) x 10^-3 eV^2. The atmospheric mixing angle is within 0.407 <= sin^2 theta_{23} <= 0.583 at 90% C.L., Comment: 17 Pages, 14 figures. To be submitted to Phys. Rev. D Minor update to text after referee comments. Figures modified for better grayscale printing.

Published
2010
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7. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells

Author

Ueno, K, Hazama, S, Mitomori, S, Nishioka, M, Suehiro, Y, Hirata, H, Oka, M, Imai, K, Dahiya, R, and Hinoda, Y

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Cancer, Colo-Rectal Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Cell Survival, Colorectal Neoplasms, Frizzled Receptors, HCT116 Cells, HT29 Cells, Humans, Liver Neoplasms, Experimental, Mice, Mice, SCID, Neoplasm Invasiveness, RNA, Messenger, RNA, Small Interfering, Receptors, G-Protein-Coupled, frizzled-7, siRNA, colorectal cancer, metastasis, RhoA, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThe canonical Wnt signalling pathway is activated in most sporadic colorectal cancers (CRCs). We previously reported that FZD7 functions as a receptor for the canonical Wnt signalling pathway in colon cancer cells.Methods and resultsIn this study, we examined the function of FZD7 in survival, invasion and metastatic capabilities of colon cancer cells. FZD7_siRNA transfection decreased cell viability of HT-29 and HCT-116 colon cancer cells. Expression of c-Jun, phosphorylation of JNK and c-Jun, and activation of RhoA were suppressed after FZD7_siRNA transfection into HCT-116 cells. In vitro invasion activity and Wnt target gene expression were also reduced in HCT-116 cells transfected with FZD7_siRNA. Liver metastasis of stable FZD7_siRNA HCT-116 cell transfectants in scid mice was decreased to 40-50% compared to controls. The mRNA levels of FZD7 in 135 primary CRC tissues were examined by real-time PCR. FZD7 mRNA levels were significantly higher in stage II, III or IV tumours than in non-tumour tissues (P

Published
2009

8. Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

Author

Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Yili, Zhang, G., Yoshino, T., Taniguchi, H., Bifulco, C., Lugli, A., Lee, J.J., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, Elisa, Hartmann, A., Geppert, C.I., Kolwelter, J., Merkel, S., Grützmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Léonard, D., Remue, C., Wang, J., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Marliot, F., Fredriksen, T., Buttard, B., Lafontaine, L., Maby, P., Majdi, A., Hijazi, A., Sissy, C. El, Kirilovsky, A., Berger, A., Lagorce, C., Paustian, C., Ballesteros-Merino, C., Dijkstra, J.R., Water, C. van de, Lent-van Vliet, S. van, Knijn, N., Mușină, A.M., Scripcariu, D.V., Marincola, F.M., Ascierto, P.A., Fox, B.A., Pagès, F., Kawakami, Y., Galon, J., Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Yili, Zhang, G., Yoshino, T., Taniguchi, H., Bifulco, C., Lugli, A., Lee, J.J., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, Elisa, Hartmann, A., Geppert, C.I., Kolwelter, J., Merkel, S., Grützmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Léonard, D., Remue, C., Wang, J., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Marliot, F., Fredriksen, T., Buttard, B., Lafontaine, L., Maby, P., Majdi, A., Hijazi, A., Sissy, C. El, Kirilovsky, A., Berger, A., Lagorce, C., Paustian, C., Ballesteros-Merino, C., Dijkstra, J.R., Water, C. van de, Lent-van Vliet, S. van, Knijn, N., Mușină, A.M., Scripcariu, D.V., Marincola, F.M., Ascierto, P.A., Fox, B.A., Pagès, F., Kawakami, Y., and Galon, J.

Abstract

Contains fulltext : 283495.pdf (Publisher’s version ) (Open Access), BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10-4.55) p = 0.0269) of the patient's gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27-9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35-5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21-5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39-6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.

Published
2022

10. First study of neutron tagging with a water Cherenkov detector

Author

Watanabe, H., Zhang, H., Abe, K., Hayato, Y., Iida, T., Ikeda, M., Kameda, J., Kobayashi, K., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Ogawa, H., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Takeuchi, Y., Ueno, K., Ueshima, K., Yamada, S., Hazama, S., Higuchi, I., Ishihara, C., Kajita, T., Kaneyuki, K., Mitsuka, G., Nishino, H., Okumura, K., Tanimoto, N., Clark, S., Desai, S., Dufour, F., Kearns, E., Likhoded, S., Litos, M., Raaf, J., Stone, J.L., Sulak, L.R., Wang, W., Goldhaber, M., Bays, K., Casper, D., Cravens, J.P., Dunmore, J., Griskevich, J., Kropp, W.R., Liu, D.W., Mine, S., Regis, C., Smy, M.B., Sobel, H.W., Ganezer, K.S., Hill, J., Keig, W.E., Jang, J.S., Jeong, I.S., Kim, J.Y., Lim, I.T., Fechner, M., Scholberg, K., Walter, C.W., Wendel, R., Tasaka, S., Guillian, G., Learned, J.G., Matsuno, S., Messier, M.D., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A.T., Ichikawa, A.K., Minamino, A., Nakaya, T., Yokoyama, M., Haines, T.J., Dazeley, S., Svoboda, R., Gran, R., Habig, A., Fukuda, Y., Itow, Y., Tanaka, T., Jung, C.K., McGrew, C., Sarrat, A., Terri, R., Yanagisawa, C., Tamura, N., Idehara, Y., Ishino, H., Kibayashi, A., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S.B., Yang, B.S., Ishizuka, T., Okazawa, H., Choi, Y., Seo, H.K., Furuse, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Vagins, M.R., Chen, S., Deng, Z., Gong, G., Liu, Y., Xue, T., Kielczewska, D., Berns, H.G., Shiraishi, K.K., Thrane, E., and Wilkes, R.J.

Published
2009
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13. Cancer stem-like phenotypes including immune surveillance and its responsible genes in induced liver cancer stem-like cells

Author

Tsunedomi, R., primary, Yoshimura, K., additional, Kimura, Y., additional, Nishiyama, M., additional, Matsukuma, S., additional, Tokumitsu, Y., additional, Tomochika, S., additional, Iida, M., additional, Suzuki, N., additional, Takeda, S., additional, Yoshino, S., additional, Hazama, S., additional, and Nagano, H., additional

Published
2019
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15. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Author

Pages, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F.S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grutzmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Leonard, D., Remue, C., Wang, J.Y., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E.K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S.E., Angell, H.K., Lafontaine, L., Bruni, D., Sissy, C. El, Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J.P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., Water, C. van de, Vliet, S. van, Knijn, N., Musina, A.M., Scripcariu, D.V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P.S., Vora, H.H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F.M., Ascierto, P.A., Sargent, D.J., Fox, B.A., Galon, J., Pages, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F.S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grutzmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Leonard, D., Remue, C., Wang, J.Y., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E.K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S.E., Angell, H.K., Lafontaine, L., Bruni, D., Sissy, C. El, Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J.P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., Water, C. van de, Vliet, S. van, Knijn, N., Musina, A.M., Scripcariu, D.V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P.S., Vora, H.H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F.M., Ascierto, P.A., Sargent, D.J., Fox, B.A., and Galon, J.

Abstract

Contains fulltext : 193579.pdf (publisher's version ) (Closed access), BACKGROUND: The estimation of risk of recurrence for patients with colon carcinoma must be improved. A robust immune score quantification is needed to introduce immune parameters into cancer classification. The aim of the study was to assess the prognostic value of total tumour-infiltrating T-cell counts and cytotoxic tumour-infiltrating T-cells counts with the consensus Immunoscore assay in patients with stage I-III colon cancer. METHODS: An international consortium of 14 centres in 13 countries, led by the Society for Immunotherapy of Cancer, assessed the Immunoscore assay in patients with TNM stage I-III colon cancer. Patients were randomly assigned to a training set, an internal validation set, or an external validation set. Paraffin sections of the colon tumour and invasive margin from each patient were processed by immunohistochemistry, and the densities of CD3+ and cytotoxic CD8+ T cells in the tumour and in the invasive margin were quantified by digital pathology. An Immunoscore for each patient was derived from the mean of four density percentiles. The primary endpoint was to evaluate the prognostic value of the Immunoscore for time to recurrence, defined as time from surgery to disease recurrence. Stratified multivariable Cox models were used to assess the associations between Immunoscore and outcomes, adjusting for potential confounders. Harrell's C-statistics was used to assess model performance. FINDINGS: Tissue samples from 3539 patients were processed, and samples from 2681 patients were included in the analyses after quality controls (700 patients in the training set, 636 patients in the internal validation set, and 1345 patients in the external validation set). The Immunoscore assay showed a high level of reproducibility between observers and centres (r=0.97 for colon tumour; r=0.97 for invasive margin; p<0.0001). In the training set, patients with a high Immunoscore had the lowest risk of recurrence at 5 years (14 [8%] patients with a high Immunosc

Published
2018

17. Multicenter phase II study of biweekly XELIRI plus bevacizumab as a second-line therapy in patients with metastatic colorectal cancer (JSWOG-C3 study)

Author

Mori, Y., primary, Suzuki, N., additional, Nagasaka, T., additional, Tanioka, H., additional, Iwamoto, Y., additional, Neki, Y., additional, Yamatsuji, T., additional, Kobayashi, M., additional, Nakajima, M., additional, Ojima, Y., additional, Ikeda, S., additional, Kawamoto, K., additional, Shinozaki, K., additional, Tsuji, A., additional, Hinoi, T., additional, Yamaguchi, Y., additional, Yamashita, K., additional, Shimokawa, M., additional, Okajima, M., additional, and Hazama, S., additional

Published
2017
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18. P-087 A phase II study of a combination treatment of alternate-day S-1 and lentinan as first-line chemotherapy for unresectable or recurrent gastric cancer

Author

Yoshino, S., primary, Nishimura, T., additional, Sakata, K., additional, Yoshida, S., additional, Furuya, T., additional, Yamamoto, T., additional, Kawaoka, T., additional, Shimizu, R., additional, Sato, T., additional, Matoba, K., additional, Morioka, H., additional, Iida, M., additional, Suzuki, N., additional, Takeda, S., additional, Ueno, T., additional, Hazama, S., additional, and Nagano, H., additional

Published
2016
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19. An Indirect Search for WIMPs in the Sun using 3109.6 days of upward-going muons in Super-Kamiokande

Author

Kamiokande Collaboration, Tanaka, T., Abe, K., Hayato, Y., Iida, T., Kameda, J., Koshio, Y., Kouzuma, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Ueno, K., Ueshima, K., Yamada, S., Yokozawa, T., Ishihara, C., Hazama, S., Kaji, H., Kajita, T., Kaneyuki, K., McLachlan, T., Okumura, K., Shimizu, Y., Tanimoto, N., Dufour, F., Kearns, E., Litos3, M., Raaf, J. L., Stone, J. L., Sulak, L. R., Cravens, J. P., Bays, K., Kropp, W. R., Mine, S., Regis, C., Smy, M. B., Sobel, H. W., Ganezer, K. S., Hill, J., Keig, W. E., Jang, J. S., Kim, J. Y., Lim, I. T., Albert, J. B., Scholberg, K., Walter, C. W., Wendell, R., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J. G., Matsuno, S., Smith, S., Martens, K., Vagins, M., Watanabe, Y., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Nishino, H., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A. T., Takeuchi, Y., Ikeda, M., Minamino, A., Nakaya, T., Labarga, L., Fukuda, Y., Itow, Y., Mitsuka, G., Jung, C. K., McGrew, C., Lopez, G., Yanagisawa, C., Tamura, N., Ishino, H., Kibayashi, A., Sakuda, M., Kuno, Y., Yoshida, M., Kim, S. B., Yang, B. S., Okazawa, H., Choi, Y., Nishijima, K., Yokosawa, Y., Koshiba, M., Totsuka, Y., Yokoyama, M., Chen, S., Heng, Y., Yang, Z., Zhang, H., Kielczewska, D., Mijakowski, P., Connolly, K., Dziomba, M., Thrane, E., and Wilkes, R. J.

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Experiment (hep-ex), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

We present the result of an indirect search for high energy neutrinos from WIMP annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Datasets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C.L. upper limits of upward-going muon flux induced by WIMPs of 100 GeV/c$^2$ were 6.4$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ and 4.0$\times10^{-15}$ cm$^{-2}$ sec$^{-1}$ for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5$\times10^{-39}$ cm$^{-2}$ and 2.7$\times10^{-40}$ cm$^{-2}$ for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively., Add journal reference. Also fixed typo and cosmetic things in the old draft

Published
2011

20. 518 A multicenter prospective single-arm study to assess the predictive biomarkers of PSK responder from the analysis of cytokine promoter gene polymorphisms in patients with stage II or III colorectal cancer

Author

Nishimura, T., primary, Yoshino, S., additional, Sakata, K., additional, Furuya, T., additional, Inoue, K., additional, Saeki, T., additional, Takemoto, K., additional, Etoh, R., additional, Kawaoka, T., additional, Hasegawa, H., additional, Kondo, H., additional, Araki, A., additional, Kudo, A., additional, Hashimoto, K., additional, Uchiyama, T., additional, Yamamoto, T., additional, Inoue, Y., additional, Okayama, N., additional, Hazama, S., additional, and Nagano, H., additional

Published
2015
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21. 530 A phase II study of cancer vaccination using three peptides combination with gemcitabine as a first-line therapy for advanced pancreatic cancer (VENUS-PC study)

Author

Iguchi, H., primary, Suzuki, N., additional, Uesugi, K., additional, Tanaka, H., additional, Hirakawa, K., additional, Aruga, A., additional, Hatori, T., additional, Ishizaki, H., additional, Umeda, Y., additional, Fujiwara, T., additional, Shimada, M., additional, Ikemoto, T., additional, Yoshimatsu, K., additional, Shimizu, R., additional, Hayashi, H., additional, Sakata, K., additional, Yoshino, S., additional, Furukawa, H., additional, Hazama, S., additional, and Oka, M., additional

Published
2015
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22. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

Author

Galon, J., Mlecnik, B., Bindea, G., Angell, H.K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C., Nagtegaal, I.D., Palmqvist, R., Masucci, G.V., Botti, G., Tatangelo, F., Delrio, P., Maio, M., Laghi, L., Grizzi, F., Asslaber, M., D'Arrigo, C., Vidal-Vanaclocha, F., Zavadova, E., Chouchane, L., Ohashi, P.S., Hafezi-Bakhtiari, S., Wouters, B.G., Roehrl, M., Nguyen, L, Kawakami, Y., Hazama, S., Okuno, K., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P.S., Shukla, S.N., Wang, Y., Kopetz, S., Sinicrope, F.A., Scripcariu, V., Ascierto, P.A., Marincola, F.M., Fox, B.A., Pages, F., Galon, J., Mlecnik, B., Bindea, G., Angell, H.K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C., Nagtegaal, I.D., Palmqvist, R., Masucci, G.V., Botti, G., Tatangelo, F., Delrio, P., Maio, M., Laghi, L., Grizzi, F., Asslaber, M., D'Arrigo, C., Vidal-Vanaclocha, F., Zavadova, E., Chouchane, L., Ohashi, P.S., Hafezi-Bakhtiari, S., Wouters, B.G., Roehrl, M., Nguyen, L, Kawakami, Y., Hazama, S., Okuno, K., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P.S., Shukla, S.N., Wang, Y., Kopetz, S., Sinicrope, F.A., Scripcariu, V., Ascierto, P.A., Marincola, F.M., Fox, B.A., and Pages, F.

Abstract

Contains fulltext : 137112.pdf (publisher's version ) (Open Access), The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named 'Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).

Published
2014

23. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

Author

Galon, J, Mlecnik, B, Bindea, G, Angell, HK, Berger, A, Lagorce, C, Lugli, A, Zlobec, I, Hartmann, A, Bifulco, C, Nagtegaal, ID, Palmqvist, R, Masucci, GV, Botti, G, Tatangelo, F, Delrio, P, Maio, M, Laghi, L, Grizzi, F, Asslaber, M, D'Arrigo, C, Vidal-Vanaclocha, F, Zavadova, E, Chouchane, L, Ohashi, PS, Hafezi-Bakhtiari, S, Wouters, BG, Roehrl, M, Nguyen, L, Kawakami, Y, Hazama, S, Okuno, K, Ogino, S, Gibbs, P, Waring, P, Sato, N, Torigoe, T, Itoh, K, Patel, PS, Shukla, SN, Wang, Y, Kopetz, S, Sinicrope, FA, Scripcariu, V, Ascierto, PA, Marincola, FM, Fox, BA, Pages, F, Galon, J, Mlecnik, B, Bindea, G, Angell, HK, Berger, A, Lagorce, C, Lugli, A, Zlobec, I, Hartmann, A, Bifulco, C, Nagtegaal, ID, Palmqvist, R, Masucci, GV, Botti, G, Tatangelo, F, Delrio, P, Maio, M, Laghi, L, Grizzi, F, Asslaber, M, D'Arrigo, C, Vidal-Vanaclocha, F, Zavadova, E, Chouchane, L, Ohashi, PS, Hafezi-Bakhtiari, S, Wouters, BG, Roehrl, M, Nguyen, L, Kawakami, Y, Hazama, S, Okuno, K, Ogino, S, Gibbs, P, Waring, P, Sato, N, Torigoe, T, Itoh, K, Patel, PS, Shukla, SN, Wang, Y, Kopetz, S, Sinicrope, FA, Scripcariu, V, Ascierto, PA, Marincola, FM, Fox, BA, and Pages, F

Abstract

The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named 'Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).

Published
2014

24. A detector to monitor the neutrino beam asymmetry at the T2K 280m hall

Author

Ariga, A., Bay, F., Ereditato, A., Frank, E., Hess, M., Messina, M., Schutz, H.-U., Autiero, D., Carlus, B., Cazes, A., Chaussard, L., Declais, Y., Gardien, S., Girerd, C., Guerin, C., Marteau, J., Hazama, S., Ishihara, C., Kaji, H., Kajita, T., Kaneyuki, K., Okumura, K., Shimizu, Y., Tanimoto, N., Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), OPERA, and Girod, Dominique

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics::Instrumentation and Detectors, High Energy Physics::Experiment, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

We propose to build and operate a new detector for the T2K 280m hall with the purpose of measuring and monitoring the possible neutrino beam left-right asymmetry with respect to the beam axis. The measurement will be performed by means of two identical detectors (modules) made of a sandwich of iron plates and planes of scintillator bars read out by WLS fibers and multianode PMTs. The two modules could be swapped in their positions in order to minimize systematic errors. We show that an overall uncertainty of less than 5% in the measurement of the beam asymmetry could be reached within one year of running.

Published
2008

26. Cancer classification using the Immunoscore: a worldwide task force

Author

Galon, J, Pages, F, Marincola, FM, Angell, HK, Thurin, M, Lugli, A, Zlobec, I, Berger, A, Bifulco, C, Botti, G, Tatangelo, F, Britten, CM, Kreiter, S, Chouchane, L, Delrio, P, Arndt, H, Asslaber, M, Maio, M, Masucci, GV, Mihm, M, Vidal-Vanaclocha, F, Allison, JP, Gnjatic, S, Hakansson, L, Huber, C, Singh-Jasuja, H, Ottensmeier, C, Zwierzina, H, Laghi, L, Grizzi, F, Ohashi, PS, Shaw, PA, Clarke, BA, Wouters, BG, Kawakami, Y, Hazama, S, Okuno, K, Wang, E, O'Donnell-Tormey, J, Lagorce, C, Pawelec, G, Nishimura, MI, Hawkins, R, Lapointe, R, Lundqvist, A, Khleif, SN, Ogino, S, Gibbs, P, Waring, P, Sato, N, Torigoe, T, Itoh, K, Patel, PS, Shukla, SN, Palmqvist, R, Nagtegaal, ID, Wang, Y, D'Arrigo, C, Kopetz, S, Sinicrope, FA, Trinchieri, G, Gajewski, TF, Ascierto, PA, Fox, BA, Galon, J, Pages, F, Marincola, FM, Angell, HK, Thurin, M, Lugli, A, Zlobec, I, Berger, A, Bifulco, C, Botti, G, Tatangelo, F, Britten, CM, Kreiter, S, Chouchane, L, Delrio, P, Arndt, H, Asslaber, M, Maio, M, Masucci, GV, Mihm, M, Vidal-Vanaclocha, F, Allison, JP, Gnjatic, S, Hakansson, L, Huber, C, Singh-Jasuja, H, Ottensmeier, C, Zwierzina, H, Laghi, L, Grizzi, F, Ohashi, PS, Shaw, PA, Clarke, BA, Wouters, BG, Kawakami, Y, Hazama, S, Okuno, K, Wang, E, O'Donnell-Tormey, J, Lagorce, C, Pawelec, G, Nishimura, MI, Hawkins, R, Lapointe, R, Lundqvist, A, Khleif, SN, Ogino, S, Gibbs, P, Waring, P, Sato, N, Torigoe, T, Itoh, K, Patel, PS, Shukla, SN, Palmqvist, R, Nagtegaal, ID, Wang, Y, D'Arrigo, C, Kopetz, S, Sinicrope, FA, Trinchieri, G, Gajewski, TF, Ascierto, PA, and Fox, BA

Abstract

Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N) and evidence for metastases (M). However, it is now recognized that clinical outcome can significantly vary among patients within the same stage. The current classification provides limited prognostic information, and does not predict response to therapy. Recent literature has alluded to the importance of the host immune system in controlling tumor progression. Thus, evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy. Accumulating data, collected from large cohorts of human cancers, has demonstrated the impact of immune-classification, which has a prognostic value that may add to the significance of the AJCC/UICC TNM-classification. It is therefore imperative to begin to incorporate the 'Immunoscore' into traditional classification, thus providing an essential prognostic and potentially predictive tool. Introduction of this parameter as a biomarker to classify cancers, as part of routine diagnostic and prognostic assessment of tumors, will facilitate clinical decision-making including rational stratification of patient treatment. Equally, the inherent complexity of quantitative immunohistochemistry, in conjunction with protocol variation across laboratories, analysis of different immune cell types, inconsistent region selection criteria, and variable ways to quantify immune infiltration, all underline the urgent requirement to reach assay harmonization. In an effort to promote the Immunoscore in routine clinical settings, an international task force was initiated. This review represents a follow-up of the announcement of this initiative, and of the J Tr

Published
2012

31. Study of nonstandard neutrino interactions with atmospheric neutrino data in Super-Kamiokande I and II

Author

Mitsuka, G., primary, Abe, K., additional, Hayato, Y., additional, Iida, T., additional, Ikeda, M., additional, Kameda, J., additional, Koshio, Y., additional, Miura, M., additional, Moriyama, S., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Sekiya, H., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Ueno, K., additional, Ueshima, K., additional, Watanabe, H., additional, Yamada, S., additional, Hazama, S., additional, Higuchi, I., additional, Ishihara, C., additional, Kaji, H., additional, Kajita, T., additional, Kaneyuki, K., additional, Nishino, H., additional, Okumura, K., additional, Tanimoto, N., additional, Dufour, F., additional, Kearns, E., additional, Litos, M., additional, Raaf, J. L., additional, Stone, J. L., additional, Sulak, L. R., additional, Goldhaber, M., additional, Bays, K., additional, Cravens, J. P., additional, Kropp, W. R., additional, Mine, S., additional, Regis, C., additional, Smy, M. B., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Hill, J., additional, Keig, W. E., additional, Jang, J. S., additional, Kim, J. Y., additional, Lim, I. T., additional, Albert, J., additional, Scholberg, K., additional, Walter, C. W., additional, Wendell, R., additional, Ishizuka, T., additional, Tasaka, S., additional, Learned, J. G., additional, Matsuno, S., additional, Watanabe, Y., additional, Hasegawa, T., additional, Ishida, T., additional, Ishii, T., additional, Kobayashi, T., additional, Nakadaira, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakashita, K., additional, Sekiguchi, T., additional, Tsukamoto, T., additional, Suzuki, A. T., additional, Minamino, A., additional, Nakaya, T., additional, Yokoyama, M., additional, Fukuda, Y., additional, Itow, Y., additional, Tanaka, T., additional, Jung, C. K., additional, Lopez, G., additional, McGrew, C., additional, Yanagisawa, C., additional, Tamura, N., additional, Idehara, Y., additional, Sakuda, M., additional, Kuno, Y., additional, Yoshida, M., additional, Kim, S. B., additional, Yang, B. S., additional, Okazawa, H., additional, Choi, Y., additional, Seo, H. K., additional, Furuse, Y., additional, Nishijima, K., additional, Yokosawa, Y., additional, Koshiba, M., additional, Totsuka, Y., additional, Chen, S., additional, Liu, J., additional, Heng, Y., additional, Yang, Z., additional, Zhang, H., additional, Kielczewska, D., additional, Connolly, K., additional, Thrane, E., additional, and Wilkes, R. J., additional

Published
2011
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36. The Importance of Evaluation of DNA Amplificability in KRAS Mutation Testing with Dideoxy Sequencing using Formalin-fixed and Paraffin-embedded Colorectal Cancer Tissues

Author

Okayama, N., primary, Nishioka, M., additional, Hazama, S., additional, Sakai, K., additional, Suehiro, Y., additional, Maekawa, M., additional, Sakamoto, J.-i., additional, Iwamoto, S., additional, Kato, T., additional, Mishima, H., additional, Oka, M., additional, and Hinoda, Y., additional

Published
2010
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37. Atmospheric neutrino oscillation analysis with subleading effects in Super-Kamiokande I, II, and III

Author

Wendell, R., primary, Ishihara, C., additional, Abe, K., additional, Hayato, Y., additional, Iida, T., additional, Ikeda, M., additional, Iyogi, K., additional, Kameda, J., additional, Kobayashi, K., additional, Koshio, Y., additional, Kozuma, Y., additional, Miura, M., additional, Moriyama, S., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Ogawa, H., additional, Sekiya, H., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Ueno, K., additional, Ueshima, K., additional, Watanabe, H., additional, Yamada, S., additional, Yokozawa, T., additional, Hazama, S., additional, Kaji, H., additional, Kajita, T., additional, Kaneyuki, K., additional, McLachlan, T., additional, Okumura, K., additional, Shimizu, Y., additional, Tanimoto, N., additional, Vagins, M. R., additional, Dufour, F., additional, Kearns, E., additional, Litos, M., additional, Raaf, J. L., additional, Stone, J. L., additional, Sulak, L. R., additional, Wang, W., additional, Goldhaber, M., additional, Bays, K., additional, Casper, D., additional, Cravens, J. P., additional, Kropp, W. R., additional, Mine, S., additional, Regis, C., additional, Smy, M. B., additional, Sobel, H. W., additional, Ganezer, K. S., additional, Hill, J., additional, Keig, W. E., additional, Jang, J. S., additional, Kim, J. Y., additional, Lim, I. T., additional, Albert, J., additional, Fechner, M., additional, Scholberg, K., additional, Walter, C. W., additional, Tasaka, S., additional, Learned, J. G., additional, Matsuno, S., additional, Watanabe, Y., additional, Hasegawa, T., additional, Ishida, T., additional, Ishii, T., additional, Kobayashi, T., additional, Nakadaira, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Nishino, H., additional, Oyama, Y., additional, Sakashita, K., additional, Sekiguchi, T., additional, Tsukamoto, T., additional, Suzuki, A. T., additional, Minamino, A., additional, Nakaya, T., additional, Fukuda, Y., additional, Itow, Y., additional, Mitsuka, G., additional, Tanaka, T., additional, Jung, C. K., additional, Lopez, G., additional, McGrew, C., additional, Yanagisawa, C., additional, Tamura, N., additional, Ishino, H., additional, Kibayashi, A., additional, Mino, S., additional, Mori, T., additional, Sakuda, M., additional, Toyota, H., additional, Kuno, Y., additional, Yoshida, M., additional, Kim, S. B., additional, Yang, B. S., additional, Ishizuka, T., additional, Okazawa, H., additional, Choi, Y., additional, Nishijima, K., additional, Yokosawa, Y., additional, Koshiba, M., additional, Yokoyama, M., additional, Totsuka, Y., additional, Chen, S., additional, Heng, Y., additional, Yang, Z., additional, Zhang, H., additional, Kielczewska, D., additional, Mijakowski, P., additional, Connolly, K., additional, Dziomba, M., additional, Thrane, E., additional, and Wilkes, R. J., additional

Published
2010
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39. Kinematic reconstruction of atmospheric neutrino events in a large water Cherenkov detector with proton identification

Author

Fechner, M., primary, Abe, K., additional, Hayato, Y., additional, Iida, T., additional, Ikeda, M., additional, Kameda, J., additional, Kobayashi, K., additional, Koshio, Y., additional, Miura, M., additional, Moriyama, S., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Ogawa, H., additional, Sekiya, H., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Ueno, K., additional, Ueshima, K., additional, Watanabe, H., additional, Yamada, S., additional, Hazama, S., additional, Higuchi, I., additional, Ishihara, C., additional, Kajita, T., additional, Kaneyuki, K., additional, Mitsuka, G., additional, Nishino, H., additional, Okumura, K., additional, Tanimoto, N., additional, Vagins, M. R., additional, Dufour, F., additional, Kearns, E., additional, Litos, M., additional, Raaf, J. L., additional, Stone, J. L., additional, Sulak, L. R., additional, Wang, W., additional, Goldhaber, M., additional, Dazeley, S., additional, Svoboda, R., additional, Bayes, K., additional, Casper, D., additional, Cravens, J. P., additional, Kropp, W. R., additional, Mine, S., additional, Regis, C., additional, Smy, M. B., additional, Sobel, H. W., additional, Ganezer, K. S., additional, Hill, J., additional, Keig, W. E., additional, Jang, J. S., additional, Kim, J. Y., additional, Lim, I. T., additional, Scholberg, K., additional, Walter, C. W., additional, Wendell, R., additional, Tasaka, S., additional, Learned, J. G., additional, Matsuno, S., additional, Watanabe, Y., additional, Hasegawa, T., additional, Ishida, T., additional, Ishii, T., additional, Kobayashi, T., additional, Nakadaira, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakashita, K., additional, Sekiguchi, T., additional, Tsukamoto, T., additional, Suzuki, A. T., additional, Minamino, A., additional, Nakaya, T., additional, Yokoyama, M., additional, Fukuda, Y., additional, Itow, Y., additional, Tanaka, T., additional, Jung, C. K., additional, Lopez, G., additional, McGrew, C., additional, Terri, R., additional, Yanagisawa, C., additional, Tamura, N., additional, Idehara, Y., additional, Sakuda, M., additional, Kuno, Y., additional, Yoshida, M., additional, Kim, S. B., additional, Yang, B. S., additional, Ishizuka, T., additional, Okazawa, H., additional, Choi, Y., additional, Seo, H. K., additional, Furuse, Y., additional, Nishijima, K., additional, Yokosawa, Y., additional, Koshiba, M., additional, Totsuka, Y., additional, Chen, S., additional, Heng, Y., additional, Yang, Z., additional, Zhang, H., additional, Kielczewska, D., additional, Thrane, E., additional, and Wilkes, R. J., additional

Published
2009
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41. SEARCH FOR NEUTRINOS FROM GRB 080319B AT SUPER-KAMIOKANDE

Author

Thrane, E., primary, Abe, K., additional, Hayato, Y., additional, Iida, T., additional, Ikeda, M., additional, Kameda, J., additional, Kobayashi, K., additional, Koshio, Y., additional, Miura, M., additional, Moriyama, S., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Ogawa, H., additional, Sekiya, H., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Ueno, K., additional, Ueshima, K., additional, Watanabe, H., additional, Yamada, S., additional, Vagins, M. R., additional, Hazama, S., additional, Higuchi, I., additional, Ishihara, C., additional, Kajita, T., additional, Kaneyuki, K., additional, Mitsuka, G., additional, Nishino, H., additional, Okumura, K., additional, Tanimoto, N., additional, Dufour, F., additional, Kearns, E., additional, Litos, M., additional, Raaf, J. L., additional, Stone, J. L., additional, Sulak, L. R., additional, Goldhaber, M., additional, Bays, K., additional, Casper, D., additional, Cravens, J. P., additional, Kropp, W. R., additional, Mine, S., additional, Regis, C., additional, Smy, M. B., additional, Sobel, H. W., additional, Ganezer, K. S., additional, Hill, J., additional, Keig, W. E., additional, Jang, J. S., additional, Jeong, I. S., additional, Kim, J. Y., additional, Lim, I. T., additional, Fechner, M., additional, Scholberg, K., additional, Walter, C. W., additional, Wendell, R., additional, Tasaka, S., additional, Learned, J. G., additional, Matsuno, S., additional, Watanabe, Y., additional, Hasegawa, T., additional, Ishida, T., additional, Ishii, T., additional, Kobayashi, T., additional, Nakadaira, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakashita, K., additional, Sekiguchi, T., additional, Tsukamoto, T., additional, Suzuki, A. T., additional, Ichikawa, A. K., additional, Minamino, A., additional, Nakaya, T., additional, Yokoyama, M., additional, Dazeley, S., additional, Svoboda, R., additional, Habig, A., additional, Fukuda, Y., additional, Itow, Y., additional, Tanaka, T., additional, Jung, C. K., additional, Lopez, G., additional, McGrew, C., additional, Yanagisawa, C., additional, Tamura, N., additional, Idehara, Y., additional, Ishino, H., additional, Kibayashi, A., additional, Sakuda, M., additional, Kuno, Y., additional, Yoshida, M., additional, Kim, S. B., additional, Yang, B. S., additional, Ishizuka, T., additional, Okazawa, H., additional, Choi, Y., additional, Seo, H. K., additional, Furuse, Y., additional, Nishijima, K., additional, Yokosawa, Y., additional, Koshiba, M., additional, Totsuka, Y., additional, Chen, S., additional, Gong, G., additional, Heng, Y., additional, Xue, T., additional, Yang, Z., additional, Zhang, H., additional, Kielczewska, D., additional, Mijakowski, P., additional, Berns, H. G., additional, Connolly, K., additional, Dziomba, M., additional, and Wilkes, R. J., additional

Published
2009
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42. Search for Proton Decay viap→e+π0andp→μ+π0in a Large Water Cherenkov Detector

Author

Nishino, H., primary, Clark, S., additional, Abe, K., additional, Hayato, Y., additional, Iida, T., additional, Ikeda, M., additional, Kameda, J., additional, Kobayashi, K., additional, Koshio, Y., additional, Miura, M., additional, Moriyama, S., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Ogawa, H., additional, Sekiya, H., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Ueno, K., additional, Ueshima, K., additional, Watanabe, H., additional, Yamada, S., additional, Hazama, S., additional, Higuchi, I., additional, Ishihara, C., additional, Kajita, T., additional, Kaneyuki, K., additional, Mitsuka, G., additional, Okumura, K., additional, Tanimoto, N., additional, Vagins, M. R., additional, Dufour, F., additional, Kearns, E., additional, Litos, M., additional, Raaf, J. L., additional, Stone, J. L., additional, Sulak, L. R., additional, Wang, W., additional, Goldhaber, M., additional, Dazeley, S., additional, Svoboda, R., additional, Bays, K., additional, Casper, D., additional, Cravens, J. P., additional, Kropp, W. R., additional, Mine, S., additional, Regis, C., additional, Smy, M. B., additional, Sobel, H. W., additional, Ganezer, K. S., additional, Hill, J., additional, Keig, W. E., additional, Jang, J. S., additional, Kim, J. Y., additional, Lim, I. T., additional, Fechner, M., additional, Scholberg, K., additional, Walter, C. W., additional, Wendell, R., additional, Tasaka, S., additional, Learned, J. G., additional, Matsuno, S., additional, Watanabe, Y., additional, Hasegawa, T., additional, Ishida, T., additional, Ishii, T., additional, Kobayashi, T., additional, Nakadaira, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakashita, K., additional, Sekiguchi, T., additional, Tsukamoto, T., additional, Suzuki, A. T., additional, Minamino, A., additional, Nakaya, T., additional, Yokoyama, M., additional, Fukuda, Y., additional, Itow, Y., additional, Tanaka, T., additional, Jung, C. K., additional, Lopez, G., additional, McGrew, C., additional, Terri, R., additional, Yanagisawa, C., additional, Tamura, N., additional, Idehara, Y., additional, Sakuda, M., additional, Kuno, Y., additional, Yoshida, M., additional, Kim, S. B., additional, Yang, B. S., additional, Ishizuka, T., additional, Okazawa, H., additional, Choi, Y., additional, Seo, H. K., additional, Furuse, Y., additional, Nishijima, K., additional, Yokosawa, Y., additional, Koshiba, M., additional, Totsuka, Y., additional, Chen, S., additional, Heng, Y., additional, Yang, Z., additional, Zhang, H., additional, Kielczewska, D., additional, Thrane, E., additional, and Wilkes, R. J., additional

Published
2009
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43. A combination chemotherapy of weekly paclitaxel and doxifluridine (5’-DFUR: an intermediate metabolite of capecitabine) in patients with unresectable or recurrent gastric cancer in an outpatient setting. Final results of a multicenter phase II trial

Author

Yoshino, S., primary, Nishimura, T., additional, Hazama, S., additional, Oka, M., additional, Ozasa, H., additional, Shimizu, R., additional, Furuya, T., additional, Fukuda, S., additional, Satoh, T., additional, and Hara, T., additional

Published
2007
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44. UGT1As polymorphisms predict toxicity in colorectal cancer patients treated with different recommended doses of irinotecan oriented by UGT1A1*28 polymorphism based on previous phase I study

Author

Hazama, S., primary, Koudo, H., additional, Yoshida, S., additional, Shimizu, R., additional, Ozasa, H., additional, Yamamoto, T., additional, Araki, A., additional, Yoshino, S., additional, Okayama, N., additional, Hinoda, Y., additional, and Oka, M., additional

Published
2007
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